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Mikhail Ivanovich Papisov, Ph.D.

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Outstanding Pharmaceutical Paper Award

Research focus: Investigation of in vivo transport processes; development and characterization of macromolecular and supramolecular therapeutics, novel biomaterials; drug delivery to cancer and CNS.

The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01NS092838 (PAPISOV, MIKHAIL I) May 1, 2015 - Apr 30, 2019
    Factors of cerebrospinal drug transport
    Role: Principal Investigator
  2. R21CA191979 (PAPISOV, MIKHAIL I) Dec 1, 2014 - Nov 30, 2017
    Investigation of systemic lymphatic uptake of macromolecules
    Role: Principal Investigator
  3. R21NS090049 (PAPISOV, MIKHAIL I) Sep 15, 2014 - Aug 31, 2017
    Investigation of solute transport from the cerebrospinal fluid to CNS
    Role: Principal Investigator
  4. R21CA152384 (PAPISOV, MIKHAIL I) Aug 3, 2010 - May 31, 2013
    Macromolecular therapeutics for neoplastic meningitis
    Role: Principal Investigator
  5. R41AI052921 (PAPISOV, MIKHAIL I) Apr 15, 2003 - Apr 14, 2006
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Shao T, Chen Z, Rong J, Belov V, Chen J, Jeyarajan A, Deng X, Fu H, Yu Q, Rwema SH, Lin W, Papisov M, Josephson L, Chung RT, Liang SH. [18F]MAGL-4-11 positron emission tomography molecular imaging of monoacylglycerol lipase changes in preclinical liver fibrosis models. Acta Pharm Sin B. 2022 Jan; 12(1):308-315. PMID: 35127387.
  2. Belov V, Appleton J, Levin S, Giffenig P, Durcanova B, Papisov M. Large-Volume Intrathecal Administrations: Impact on CSF Pressure and Safety Implications. Front Neurosci. 2021; 15:604197. PMID: 33935624.
  3. Chen Z, Mori W, Fu H, Schafroth MA, Hatori A, Shao T, Zhang G, Van RS, Zhang Y, Hu K, Fujinaga M, Wang L, Belov V, Ogasawara D, Giffenig P, Deng X, Rong J, Yu Q, Zhang X, Papisov MI, Shao Y, Collier TL, Ma JA, Cravatt BF, Josephson L, Zhang MR, Liang SH. Design, Synthesis, and Evaluation of 18F-Labeled Monoacylglycerol Lipase Inhibitors as Novel Positron Emission Tomography Probes. J Med Chem. 2019 10 10; 62(19):8866-8872. PMID: 31518130.
    Citations: 5     Fields:    Translation:AnimalsCells
  4. Durcanova B, Appleton J, Gurijala N, Belov V, Giffenig P, Moeller E, Hogan M, Lee F, Papisov M. The Configuration of the Perivascular System Transporting Macromolecules in the CNS. Front Neurosci. 2019; 13:511. PMID: 31191221.
    Citations: 3     
  5. Fu H, Tang W, Chen Z, Belov VV, Zhang G, Shao T, Zhang X, Yu Q, Rong J, Deng X, Han W, Myers SJ, Giffenig P, Wang L, Josephson L, Shao Y, Davenport AT, Daunais JB, Papisov M, Yuan H, Li Z, Traynelis SF, Liang SH. Synthesis and Preliminary Evaluations of a Triazole-Cored Antagonist as a PET Imaging Probe ([18F]N2B-0518) for GluN2B Subunit in the Brain. ACS Chem Neurosci. 2019 05 15; 10(5):2263-2275. PMID: 30698943.
    Citations: 1     Fields:    Translation:Animals
  6. Rotstein BH, Liang SH, Belov VV, Livni E, Levine DB, Bonab AA, Papisov MI, Perlis RH, Vasdev N. Practical Radiosynthesis and Preclinical Neuroimaging of [11C]isradipine, a Calcium Channel Antagonist. Molecules. 2015 May 26; 20(6):9550-9. PMID: 26016546.
    Citations: 1     Fields:    Translation:Animals
  7. Golberg A, Khan S, Belov V, Quinn KP, Albadawi H, Felix Broelsch G, Watkins MT, Georgakoudi I, Papisov M, Mihm MC, Austen WG, Austen WG, Yarmush ML. Skin rejuvenation with non-invasive pulsed electric fields. Sci Rep. 2015 May 12; 5:10187. PMID: 25965851.
    Citations: 17     Fields:    Translation:AnimalsCells
  8. Papisov MI, Belov VV, Gannon KS. Physiology of the intrathecal bolus: the leptomeningeal route for macromolecule and particle delivery to CNS. Mol Pharm. 2013 May 06; 10(5):1522-32. PMID: 23316936.
    Citations: 38     Fields:    Translation:HumansAnimals
  9. Mushti C, Papisov MI. Radioiodination of aryl-alkyl cyclic sulfates. Molecules. 2012 Nov 07; 17(11):13266-74. PMID: 23135631.
    Citations:    Fields:    Translation:Cells
  10. Papisov M, Belov V, Fischman A.J., Belova E, Titus J, Gagne M., Gillooly C. Delivery of proteins to CNS as seen and measured by Positron Emission Tomography. Drug Delivery and Translational Research. 2012; 2(3):201-209. View Publication.
  11. Papisov MI, Belov V, Fischman AJ, Belova E, Titus J, Gagne M, Gillooly C. Delivery of proteins to CNS as seen and measured by positron emission tomography. Drug Deliv Transl Res. 2012 Jun; 2(3):201-9. PMID: 25786867.
    Citations: 12     Fields:    
  12. Papisov MI, Belov V, Belova E, Fischman AJ, Fisher R, Wright JL, Gannon KS, Titus J, Gagne M, Gillooly CA. Investigation of intrathecal transport of NPT002, a prospective therapeutic based on phage M13, in nonhuman primates. Drug Deliv Transl Res. 2012 Jun; 2(3):210-21. PMID: 25786868.
    Citations: 5     Fields:    
  13. Papisov M, Belov V, Belova E, Fischman A.J., Fisher R, Wright J, Ganon K, Titus J, Gagne M., Gillooly C. Investigation of intrathecal transport of NPT002, a prospective therapeutic based on phage M13, in non-human primates. Drug Delivery and Translational Research. 2012; 2(3):210-221. View Publication.
  14. Calias P, Papisov M, Pan J, Savioli N, Belov V, Huang Y, Lotterhand J, Alessandrini M, Liu N, Fischman AJ, Powell JL, Heartlein MW. CNS penetration of intrathecal-lumbar idursulfase in the monkey, dog and mouse: implications for neurological outcomes of lysosomal storage disorder. PLoS One. 2012; 7(1):e30341. PMID: 22279584.
    Citations: 50     Fields:    Translation:HumansAnimalsCells
  15. Chandra Mushti and Mikhail I. Papisov. Molecules. Radioiodination of Aryl-Alkyl Cyclic Sulfates. 2012; 17(11):13266-13274. View Publication.
  16. Belov VV, Bonab AA, Fischman AJ, Heartlein M, Calias P, Papisov MI. Iodine-124 as a label for pharmacological PET imaging. Mol Pharm. 2011 Jun 06; 8(3):736-47. PMID: 21361362.
    Citations: 11     Fields:    Translation:HumansAnimals
  17. Apidianakis Y, Mindrinos MN, Xiao W, Tegos GP, Papisov MI, Hamblin MR, Davis RW, Tompkins RG, Rahme LG. Involvement of skeletal muscle gene regulatory network in susceptibility to wound infection following trauma. PLoS One. 2007 Dec 26; 2(12):e1356. PMID: 18159239.
    Citations: 23     Fields:    Translation:HumansAnimalsCells
  18. Yurkovetskiy A, Choi S, Hiller A, Yin M, McCusker C, Syed S, Fischman AJ, Papisov MI. Fully degradable hydrophilic polyals for protein modification. Biomacromolecules. 2005 Sep-Oct; 6(5):2648-58. PMID: 16153103.
    Citations: 1     Fields:    Translation:AnimalsCells
  19. Papisov MI, Hiller A, Yurkovetskiy A, Yin M, Barzana M, Hillier S, Fischman AJ. Semisynthetic hydrophilic polyals. Biomacromolecules. 2005 Sep-Oct; 6(5):2659-70. PMID: 16153104.
    Citations: 3     Fields:    Translation:AnimalsCells
  20. Papisov MI, Yurkovetskiy A, Syed S, Koshkina N, Yin M, Hiller A, Fischman AJ. A systemic route for drug loading to lymphatic phagocytes. Mol Pharm. 2005 Jan-Feb; 2(1):47-56. PMID: 15804177.
    Citations:    Fields:    Translation:AnimalsCells
  21. Yurkovetskiy AV, Hiller A, Syed S, Yin M, Lu XM, Fischman AJ, Papisov MI. Synthesis of a macromolecular camptothecin conjugate with dual phase drug release. Mol Pharm. 2004 Sep-Oct; 1(5):375-82. PMID: 16026008.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  22. Papisov MI. Theoretical considerations of RES-avoiding liposomes: Molecular mechanics and chemistry of liposome interactions. Adv Drug Deliv Rev. 1998 Jun 08; 32(1-2):119-138. PMID: 10837639.
    Citations: 15     Fields:    
  23. Harika L, Weissleder R, Poss K, Papisov MI. Macromolecular intravenous contrast agent for MR lymphography: characterization and efficacy studies. Radiology. 1996 Feb; 198(2):365-70. PMID: 8596833.
    Citations: 6     Fields:    Translation:Animals
  24. Papisov M, Weissleder R. Drug delivery to lymphatic tissue. Crit Rev Ther Drug Carrier Syst. 1996; 13(1-2):57-84. PMID: 8853959.
    Citations: 4     Fields:    Translation:AnimalsCells
  25. Frank H, Weissleder R, Papisov M. [Presentation and quantification of acute myocardial infarct using antibody-bound MR contrast medium]. Z Kardiol. 1995 Apr; 84(4):311-5. PMID: 7785304.
    Citations:    Fields:    Translation:Animals
  26. Papisov MI. Adv. Drug Delivery Rev. Modeling in vivo transfer of long-circulating polymers (two classes of long circulating polymers and factors affecting their transfer in vivo). 1995; 16:127-137.
  27. Harika L, Weissleder R, Poss K, Zimmer C, Papisov MI, Brady TJ. MR lymphography with a lymphotropic T1-type MR contrast agent: Gd-DTPA-PGM. Magn Reson Med. 1995 Jan; 33(1):88-92. PMID: 7891541.
    Citations: 9     Fields:    Translation:Animals
  28. van Everdingen KJ, Enochs WS, Bhide PG, Nossiff N, Papisov M, Bogdanov A, Brady TJ, Weissleder R. Determinants of in vivo MR imaging of slow axonal transport. Radiology. 1994 Nov; 193(2):485-91. PMID: 7526413.
    Citations: 5     Fields:    Translation:Animals
  29. Torchilin VP, Omelyanenko VG, Papisov MI, Bogdanov AA, Trubetskoy VS, Herron JN, Gentry CA. Poly(ethylene glycol) on the liposome surface: on the mechanism of polymer-coated liposome longevity. Biochim Biophys Acta. 1994 Oct 12; 1195(1):11-20. PMID: 7918551.
    Citations: 95     Fields:    Translation:Cells
  30. Weissleder R, Heautot JF, Schaffer BK, Nossiff N, Papisov MI, Bogdanov A, Brady TJ. MR lymphography: study of a high-efficiency lymphotrophic agent. Radiology. 1994 Apr; 191(1):225-30. PMID: 8134576.
    Citations: 10     Fields:    Translation:Animals
  31. Torchilin VP, Papisov MI. Why do PEG-coated liposomes circulate long?. J. Liposome Res. 1994; 4:725-739.
  32. Garrido L, Pfleiderer B, Papisov M, Ackerman JL. In vivo degradation of silicones. Magn Reson Med. 1993 Jun; 29(6):839-43. PMID: 8350731.
    Citations: 5     Fields:    Translation:Animals
  33. Shen T, Weissleder R, Papisov M, Bogdanov A, Brady TJ. Monocrystalline iron oxide nanocompounds (MION): physicochemical properties. Magn Reson Med. 1993 May; 29(5):599-604. PMID: 8505895.
    Citations: 121     Fields:    
  34. Schaffer BK, Linker C, Papisov M, Tsai E, Nossiff N, Shibata T, Bogdanov A, Brady TJ, Weissleder R. MION-ASF: biokinetics of an MR receptor agent. Magn Reson Imaging. 1993; 11(3):411-7. PMID: 7685055.
    Citations: 3     Fields:    Translation:Animals
  35. Enochs WS, Schaffer B, Bhide PG, Nossiff N, Papisov M, Bogdanov A, Jr, Brady TJ, Weissleder R. MR imaging of slow axonal transport in vivo. Exp Neurol. 1993; 123:235-242.
  36. Papisov MI, Sinitsyn VE Shchipanova, IV, Sergienko VB, Belenkov YuN. Experimental use of magnetite colloid solution as a supramagentic parenteral and oral contrast agent in magentic resonance tomography. Medical Radiology and Radiation Safety (Rus). 1993; 38(11):4-7.
  37. Weissleder R, Bogdanov A, Papisov M. Drug targeting in magnetic resonance imaging. Magn Reson Q. 1992 Mar; 8(1):55-63. PMID: 1567758.
    Citations: 4     Fields:    Translation:HumansAnimals
  38. Papisov MI, Svel'ev VIu, Segienko VB, Torchilin VP. [Biokinetics of magnetic carriers for directed transport of drugs]. Antibiot Khimioter. 1988 Oct; 33(10):744-51. PMID: 3214207.
    Citations:    Fields:    Translation:Animals
  39. Papisov MI, Torchilin VP. [Prediction of the biological effect of magnetically regulated drugs]. Antibiot Khimioter. 1988 Oct; 33(10):751-7. PMID: 3214208.
    Citations:    Fields:    
  40. Torchilin VP, Papisov MI, Orekhova NM, Belyaev AA, Petrov AD, Ragimov SE. Magnetically driven thrombolytic preparation containing immobilized streptokinase-targeted transport and action. Haemostasis. 1988; 18(2):113-6. PMID: 3410361.
    Citations: 2     Fields:    Translation:Animals
  41. Papisov MI, Savelyev VY, Sergienko VB, Torchilin VP. Magnetic drug targeting (I) In vivo kinetics of radiolabeled magnetic drug carriers. Int. J. Pharm. 1987; 40:201-206.
  42. Papisov MI, Torchilin VP. Magnetic drug targeting (II) Targeted drug transport by magnetic microparticles: factors influencing therapeutic effect. Int. J. Pharm. 1987; 40:207-214.
  43. Torchilin VP, Maksimenko AV, Tishchenko EG, Papisov MI, Smirnov VN. [Drug preparations of immobilized enzymes with enhanced affinity for the site of action]. Antibiot Med Biotekhnol. 1986 Feb; 31(2):122-7. PMID: 2421639.
    Citations:    Fields:    Translation:Animals
  44. Torchilin VP, Papisov MI, Smirnov VN. Magnetic Sephadex as a carrier for enzyme immobilization and drug targeting. J Biomed Mater Res. 1985 Apr; 19(4):461-6. PMID: 2414302.
    Citations: 2     Fields:    Translation:Humans
  45. Papisov MI, Samokhin GP, Smirnov MD, Torcholin VP, Smirnov VN. [Possibilities of using ferromagnetic materials for targeted drug transport]. Biull Eksp Biol Med. 1984 Sep; 98(9):372-4. PMID: 6207870.
    Citations:    Fields:    Translation:Animals
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.