Harvard Catalyst Profiles

Contact, publication, and social network information about Harvard faculty and fellows.

Christoph Lange, Ph.D.

Co-Author

This page shows the publications co-authored by Christoph Lange and Nan Laird.
Connection Strength

6.165
  1. Family-based methods for linkage and association analysis. Adv Genet. 2008; 60:219-52.
    View in: PubMed
    Score: 0.382
  2. Family-based designs in the age of large-scale gene-association studies. Nat Rev Genet. 2006 May; 7(5):385-94.
    View in: PubMed
    Score: 0.340
  3. A family-based association test for repeatedly measured quantitative traits adjusting for unknown environmental and/or polygenic effects. Stat Appl Genet Mol Biol. 2004; 3:Article17.
    View in: PubMed
    Score: 0.302
  4. PBAT: tools for family-based association studies. Am J Hum Genet. 2004 Feb; 74(2):367-9.
    View in: PubMed
    Score: 0.291
  5. Family-based association tests for survival and times-to-onset analysis. Stat Med. 2004 Jan 30; 23(2):179-89.
    View in: PubMed
    Score: 0.291
  6. Using the noninformative families in family-based association tests: a powerful new testing strategy. Am J Hum Genet. 2003 Oct; 73(4):801-11.
    View in: PubMed
    Score: 0.283
  7. A multivariate family-based association test using generalized estimating equations: FBAT-GEE. Biostatistics. 2003 Apr; 4(2):195-206.
    View in: PubMed
    Score: 0.274
  8. Power and design considerations for a general class of family-based association tests: quantitative traits. Am J Hum Genet. 2002 Dec; 71(6):1330-41.
    View in: PubMed
    Score: 0.268
  9. Power calculations for a general class of family-based association tests: dichotomous traits. Am J Hum Genet. 2002 Sep; 71(3):575-84.
    View in: PubMed
    Score: 0.263
  10. On a general class of conditional tests for family-based association studies in genetics: the asymptotic distribution, the conditional power, and optimality considerations. Genet Epidemiol. 2002 Aug; 23(2):165-80.
    View in: PubMed
    Score: 0.262
  11. Genome-wide association analysis of COVID-19 mortality risk in SARS-CoV-2 genomes identifies mutation in the SARS-CoV-2 spike protein that colocalizes with P.1 of the Brazilian strain. Genet Epidemiol. 2021 10; 45(7):685-693.
    View in: PubMed
    Score: 0.243
  12. A unifying framework for rare variant association testing in family-based designs, including higher criticism approaches, SKATs, and burden tests. Bioinformatics. 2020 Dec 26.
    View in: PubMed
    Score: 0.235
  13. A comparison of popular TDT-generalizations for family-based association analysis. Genet Epidemiol. 2019 04; 43(3):300-317.
    View in: PubMed
    Score: 0.205
  14. Family-based tests for associating haplotypes with general phenotype data: Improving the FBAT-haplotype algorithm. Genet Epidemiol. 2018 02; 42(1):123-126.
    View in: PubMed
    Score: 0.189
  15. Integrating Multiple Correlated Phenotypes for Genetic Association Analysis by Maximizing Heritability. Hum Hered. 2015; 79(2):93-104.
    View in: PubMed
    Score: 0.160
  16. A novel method for detecting association between DNA methylation and diseases using spatial information. Genet Epidemiol. 2014 Dec; 38(8):714-21.
    View in: PubMed
    Score: 0.152
  17. Is it rare or common? Genet Epidemiol. 2012 Jul; 36(5):419-29.
    View in: PubMed
    Score: 0.129
  18. Combining disease models to test for gene-environment interaction in nuclear families. Biometrics. 2011 Dec; 67(4):1260-70.
    View in: PubMed
    Score: 0.119
  19. A new testing strategy to identify rare variants with either risk or protective effect on disease. PLoS Genet. 2011 Feb 03; 7(2):e1001289.
    View in: PubMed
    Score: 0.118
  20. Parsing the effects of individual SNPs in candidate genes with family data. Hum Hered. 2010; 69(2):91-103.
    View in: PubMed
    Score: 0.109
  21. Gene-environment interaction tests for dichotomous traits in trios and sibships. Genet Epidemiol. 2009 Dec; 33(8):691-9.
    View in: PubMed
    Score: 0.109
  22. Impact of population stratification on family-based association tests with longitudinal measurements. Stat Appl Genet Mol Biol. 2009; 8:Article 17.
    View in: PubMed
    Score: 0.103
  23. New powerful approaches for family-based association tests with longitudinal measurements. Ann Hum Genet. 2009 Jan; 73(1):74-83.
    View in: PubMed
    Score: 0.100
  24. On the frequency of copy number variants. Bioinformatics. 2008 Oct 15; 24(20):2350-5.
    View in: PubMed
    Score: 0.099
  25. On the analysis of copy-number variations in genome-wide association studies: a translation of the family-based association test. Genet Epidemiol. 2008 Apr; 32(3):273-84.
    View in: PubMed
    Score: 0.097
  26. On the replication of genetic associations: timing can be everything! Am J Hum Genet. 2008 Apr; 82(4):849-58.
    View in: PubMed
    Score: 0.097
  27. FBAT-SNP-PC: an approach for multiple markers and single trait in family-based association tests. Hum Hered. 2008; 66(2):122-6.
    View in: PubMed
    Score: 0.097
  28. Genomewide weighted hypothesis testing in family-based association studies, with an application to a 100K scan. Am J Hum Genet. 2007 Sep; 81(3):607-14.
    View in: PubMed
    Score: 0.092
  29. On the parsing of statistical information in family-based association testing. Nat Genet. 2007 Mar; 39(3):281-2.
    View in: PubMed
    Score: 0.090
  30. Combined analysis from eleven linkage studies of bipolar disorder provides strong evidence of susceptibility loci on chromosomes 6q and 8q. Am J Hum Genet. 2005 Oct; 77(4):582-95.
    View in: PubMed
    Score: 0.081
  31. Genomic screening and replication using the same data set in family-based association testing. Nat Genet. 2005 Jul; 37(7):683-91.
    View in: PubMed
    Score: 0.080
  32. Gene-based segregation method for identifying rare variants in family-based sequencing studies. Genet Epidemiol. 2017 05; 41(4):309-319.
    View in: PubMed
    Score: 0.045
  33. A genome-wide association study identifies risk loci for spirometric measures among smokers of European and African ancestry. BMC Genet. 2015 Dec 03; 16:138.
    View in: PubMed
    Score: 0.041
  34. Risk loci for chronic obstructive pulmonary disease: a genome-wide association study and meta-analysis. Lancet Respir Med. 2014 Mar; 2(3):214-25.
    View in: PubMed
    Score: 0.036
  35. Differentiating population stratification from genotyping error using family data. Ann Hum Genet. 2012 Jan; 76(1):42-52.
    View in: PubMed
    Score: 0.031
  36. Meta-analysis of the INSIG2 association with obesity including 74,345 individuals: does heterogeneity of estimates relate to study design? PLoS Genet. 2009 Oct; 5(10):e1000694.
    View in: PubMed
    Score: 0.027
  37. Genome-wide association scan of attention deficit hyperactivity disorder. . 2008 Dec 05; 147B(8):1337-44.
    View in: PubMed
    Score: 0.025
  38. Genome-wide association scan of quantitative traits for attention deficit hyperactivity disorder identifies novel associations and confirms candidate gene associations. . 2008 Dec 05; 147B(8):1345-54.
    View in: PubMed
    Score: 0.025
  39. Genome-wide association scan of the time to onset of attention deficit hyperactivity disorder. . 2008 Dec 05; 147B(8):1355-8.
    View in: PubMed
    Score: 0.025
  40. Genome-wide association analysis reveals putative Alzheimer's disease susceptibility loci in addition to APOE. Am J Hum Genet. 2008 Nov; 83(5):623-32.
    View in: PubMed
    Score: 0.025
  41. Family-based association analysis of a statistically derived quantitative traits for ADHD reveal an association in DRD4 with inattentive symptoms in ADHD individuals. . 2008 Jan 05; 147B(1):100-6.
    View in: PubMed
    Score: 0.024
  42. Evidence for an association of the dopamine D5 receptor gene on age at onset of attention deficit hyperactivity disorder. Ann Hum Genet. 2007 Sep; 71(Pt 5):648-59.
    View in: PubMed
    Score: 0.023
  43. The association of a SNP upstream of INSIG2 with body mass index is reproduced in several but not all cohorts. PLoS Genet. 2007 Apr 27; 3(4):e61.
    View in: PubMed
    Score: 0.023
  44. A common genetic variant is associated with adult and childhood obesity. Science. 2006 Apr 14; 312(5771):279-83.
    View in: PubMed
    Score: 0.021
  45. Genomic screening in family-based association testing. BMC Genet. 2005 Dec 30; 6 Suppl 1:S115.
    View in: PubMed
    Score: 0.021
  46. Comparison of linkage and association strategies for quantitative traits using the COGA dataset. BMC Genet. 2005 Dec 30; 6 Suppl 1:S96.
    View in: PubMed
    Score: 0.021
  47. Attempted replication of reported chronic obstructive pulmonary disease candidate gene associations. Am J Respir Cell Mol Biol. 2005 Jul; 33(1):71-8.
    View in: PubMed
    Score: 0.020
  48. The transforming growth factor-beta1 (TGFB1) gene is associated with chronic obstructive pulmonary disease (COPD). Hum Mol Genet. 2004 Aug 01; 13(15):1649-56.
    View in: PubMed
    Score: 0.019
  49. IL10 gene polymorphisms are associated with asthma phenotypes in children. Genet Epidemiol. 2004 Feb; 26(2):155-65.
    View in: PubMed
    Score: 0.018
  50. Family-based association analysis of beta2-adrenergic receptor polymorphisms in the childhood asthma management program. J Allergy Clin Immunol. 2003 Nov; 112(5):870-6.
    View in: PubMed
    Score: 0.018
  51. Univariate and multivariate family-based association analysis of the IL-13 ARG130GLN polymorphism in the Childhood Asthma Management Program. Genet Epidemiol. 2002 Nov; 23(4):335-48.
    View in: PubMed
    Score: 0.017
Connection Strength
The connection strength for co-authors is the sum of the scores for each of their shared publications.

Publication scores are based on many factors, including how long ago they were written and whether the person is a first or senior author.
Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.