Harvard Catalyst Profiles

Contact, publication, and social network information about Harvard faculty and fellows.

Christoph Lange, Ph.D.

Co-Author

This page shows the publications co-authored by Christoph Lange and Scott Weiss.
Connection Strength

6.209
  1. A new powerful non-parametric two-stage approach for testing multiple phenotypes in family-based association studies. Hum Hered. 2003; 56(1-3):10-7.
    View in: PubMed
    Score: 0.274
  2. Genome-wide association analysis of COVID-19 mortality risk in SARS-CoV-2 genomes identifies mutation in the SARS-CoV-2 spike protein that colocalizes with P.1 of the Brazilian strain. Genet Epidemiol. 2021 Jun 22.
    View in: PubMed
    Score: 0.246
  3. Unsupervised cluster analysis of SARS-CoV-2 genomes reflects its geographic progression and identifies distinct genetic subgroups of SARS-CoV-2 virus. Genet Epidemiol. 2021 04; 45(3):316-323.
    View in: PubMed
    Score: 0.239
  4. A unifying framework for rare variant association testing in family-based designs, including higher criticism approaches, SKATs, and burden tests. Bioinformatics. 2020 Dec 26.
    View in: PubMed
    Score: 0.238
  5. Unsupervised cluster analysis of SARS-CoV-2 genomes reflects its geographic progression and identifies distinct genetic subgroups of SARS-CoV-2 virus. bioRxiv. 2020 Nov 20.
    View in: PubMed
    Score: 0.236
  6. Unsupervised cluster analysis of SARS-CoV-2 genomes indicates that recent (June 2020) cases in Beijing are from a genetic subgroup that consists of mostly European and South(east) Asian samples, of which the latter are the most recent. bioRxiv. 2020 Jun 30.
    View in: PubMed
    Score: 0.230
  7. On the association analysis of genome-sequencing data: A spatial clustering approach for partitioning the entire genome into nonoverlapping windows. Genet Epidemiol. 2017 05; 41(4):332-340.
    View in: PubMed
    Score: 0.183
  8. Genomewide association between GLCCI1 and response to glucocorticoid therapy in asthma. N Engl J Med. 2011 Sep 29; 365(13):1173-83.
    View in: PubMed
    Score: 0.125
  9. A Bayesian approach to genetic association studies with family-based designs. Genet Epidemiol. 2010 Sep; 34(6):569-74.
    View in: PubMed
    Score: 0.116
  10. Asthma-susceptibility variants identified using probands in case-control and family-based analyses. BMC Med Genet. 2010 Aug 10; 11:122.
    View in: PubMed
    Score: 0.116
  11. Using canonical correlation analysis to discover genetic regulatory variants. PLoS One. 2010 May 13; 5(5):e10395.
    View in: PubMed
    Score: 0.114
  12. On genome-wide association studies for family-based designs: an integrative analysis approach combining ascertained family samples with unselected controls. Am J Hum Genet. 2010 Apr 09; 86(4):573-80.
    View in: PubMed
    Score: 0.113
  13. Development of a Pharmacogenetic Predictive Test in asthma: proof of concept. Pharmacogenet Genomics. 2010 Feb; 20(2):86-93.
    View in: PubMed
    Score: 0.112
  14. An omnibus test for family-based association studies with multiple SNPs and multiple phenotypes. Eur J Hum Genet. 2010 Jun; 18(6):720-5.
    View in: PubMed
    Score: 0.112
  15. Stronger evidence for replication of NPPA using genome-wide genotyping data. Am J Respir Crit Care Med. 2010 Jan 01; 181(1):96.
    View in: PubMed
    Score: 0.111
  16. On the analysis of genome-wide association studies in family-based designs: a universal, robust analysis approach and an application to four genome-wide association studies. PLoS Genet. 2009 Nov; 5(11):e1000741.
    View in: PubMed
    Score: 0.110
  17. Recommendations for using standardised phenotypes in genetic association studies. Hum Genomics. 2009 Jul; 3(4):308-19.
    View in: PubMed
    Score: 0.107
  18. On the adjustment for covariates in genetic association analysis: a novel, simple principle to infer direct causal effects. Genet Epidemiol. 2009 Jul; 33(5):394-405.
    View in: PubMed
    Score: 0.107
  19. IL1B polymorphisms modulate cystic fibrosis lung disease. Pediatr Pulmonol. 2009 Jun; 44(6):580-93.
    View in: PubMed
    Score: 0.107
  20. Genome-wide association analysis identifies PDE4D as an asthma-susceptibility gene. Am J Hum Genet. 2009 May; 84(5):581-93.
    View in: PubMed
    Score: 0.106
  21. Assessing the reproducibility of asthma candidate gene associations, using genome-wide data. Am J Respir Crit Care Med. 2009 Jun 15; 179(12):1084-90.
    View in: PubMed
    Score: 0.105
  22. Genome-wide association studies of family data in pharmacogenetics: a case study. Curr Pharm Des. 2009; 15(32):3764-72.
    View in: PubMed
    Score: 0.104
  23. Screening and replication using the same data set: testing strategies for family-based studies in which all probands are affected. PLoS Genet. 2008 Sep 19; 4(9):e1000197.
    View in: PubMed
    Score: 0.102
  24. On the frequency of copy number variants. Bioinformatics. 2008 Oct 15; 24(20):2350-5.
    View in: PubMed
    Score: 0.101
  25. ARG1 is a novel bronchodilator response gene: screening and replication in four asthma cohorts. Am J Respir Crit Care Med. 2008 Oct 01; 178(7):688-94.
    View in: PubMed
    Score: 0.100
  26. Association of corticotropin-releasing hormone receptor-2 genetic variants with acute bronchodilator response in asthma. Pharmacogenet Genomics. 2008 May; 18(5):373-82.
    View in: PubMed
    Score: 0.099
  27. On the replication of genetic associations: timing can be everything! Am J Hum Genet. 2008 Apr; 82(4):849-58.
    View in: PubMed
    Score: 0.098
  28. On the analysis of copy-number variations in genome-wide association studies: a translation of the family-based association test. Genet Epidemiol. 2008 Apr; 32(3):273-84.
    View in: PubMed
    Score: 0.098
  29. FBAT-SNP-PC: an approach for multiple markers and single trait in family-based association tests. Hum Hered. 2008; 66(2):122-6.
    View in: PubMed
    Score: 0.098
  30. Testing and estimating gene-environment interactions in family-based association studies. Biometrics. 2008 Jun; 64(2):458-67.
    View in: PubMed
    Score: 0.095
  31. On dichotomizing phenotypes in family-based association tests: quantitative phenotypes are not always the optimal choice. Genet Epidemiol. 2007 Jul; 31(5):376-82.
    View in: PubMed
    Score: 0.093
  32. On the parsing of statistical information in family-based association testing. Nat Genet. 2007 Mar; 39(3):281-2.
    View in: PubMed
    Score: 0.091
  33. Overview of the pharmacogenetics of asthma treatment. Pharmacogenomics J. 2006 Sep-Oct; 6(5):311-26.
    View in: PubMed
    Score: 0.086
  34. Family-based association test for time-to-onset data with time-dependent differences between the hazard functions. Genet Epidemiol. 2006 Feb; 30(2):124-32.
    View in: PubMed
    Score: 0.085
  35. Extended haplotype in the tumor necrosis factor gene cluster is associated with asthma and asthma-related phenotypes. Am J Respir Crit Care Med. 2005 Sep 15; 172(6):687-92.
    View in: PubMed
    Score: 0.081
  36. Genomic screening and replication using the same data set in family-based association testing. Nat Genet. 2005 Jul; 37(7):683-91.
    View in: PubMed
    Score: 0.081
  37. The IL12B gene is associated with asthma. Am J Hum Genet. 2004 Oct; 75(4):709-15.
    View in: PubMed
    Score: 0.077
  38. A family-based association test for repeatedly measured quantitative traits adjusting for unknown environmental and/or polygenic effects. Stat Appl Genet Mol Biol. 2004; 3:Article17.
    View in: PubMed
    Score: 0.076
  39. Association of vitamin D receptor gene polymorphisms with childhood and adult asthma. Am J Respir Crit Care Med. 2004 Nov 15; 170(10):1057-65.
    View in: PubMed
    Score: 0.076
  40. TOLL-like receptor 10 genetic variation is associated with asthma in two independent samples. Am J Respir Crit Care Med. 2004 Sep 15; 170(6):594-600.
    View in: PubMed
    Score: 0.076
  41. ADAM33 polymorphisms and phenotype associations in childhood asthma. J Allergy Clin Immunol. 2004 Jun; 113(6):1071-8.
    View in: PubMed
    Score: 0.075
  42. PBAT: tools for family-based association studies. Am J Hum Genet. 2004 Feb; 74(2):367-9.
    View in: PubMed
    Score: 0.074
  43. IL10 gene polymorphisms are associated with asthma phenotypes in children. Genet Epidemiol. 2004 Feb; 26(2):155-65.
    View in: PubMed
    Score: 0.074
  44. Family-based association analysis of beta2-adrenergic receptor polymorphisms in the childhood asthma management program. J Allergy Clin Immunol. 2003 Nov; 112(5):870-6.
    View in: PubMed
    Score: 0.072
  45. Using the noninformative families in family-based association tests: a powerful new testing strategy. Am J Hum Genet. 2003 Oct; 73(4):801-11.
    View in: PubMed
    Score: 0.072
  46. Chromosome 12q harbors multiple genetic loci related to asthma and asthma-related phenotypes. Hum Mol Genet. 2003 Aug 15; 12(16):1973-9.
    View in: PubMed
    Score: 0.071
  47. A multivariate family-based association test using generalized estimating equations: FBAT-GEE. Biostatistics. 2003 Apr; 4(2):195-206.
    View in: PubMed
    Score: 0.070
  48. Univariate and multivariate family-based association analysis of the IL-13 ARG130GLN polymorphism in the Childhood Asthma Management Program. Genet Epidemiol. 2002 Nov; 23(4):335-48.
    View in: PubMed
    Score: 0.068
  49. Polymorphisms in toll-like receptor 4 are not associated with asthma or atopy-related phenotypes. Am J Respir Crit Care Med. 2002 Dec 01; 166(11):1449-56.
    View in: PubMed
    Score: 0.067
  50. Novel recessive locus for body mass index in childhood asthma. Thorax. 2021 Apr 22.
    View in: PubMed
    Score: 0.061
  51. A novel locus for exertional dyspnoea in childhood asthma. Eur Respir J. 2021 02; 57(2).
    View in: PubMed
    Score: 0.060
  52. An interaction of the 17q12-21 locus with mold exposure in childhood asthma. Pediatr Allergy Immunol. 2021 02; 32(2):373-376.
    View in: PubMed
    Score: 0.059
  53. locStra: Fast analysis of regional/global stratification in whole-genome sequencing studies. Genet Epidemiol. 2021 Feb; 45(1):82-98.
    View in: PubMed
    Score: 0.058
  54. Whole Genome Sequencing Identifies CRISPLD2 as a Lung Function Gene in Children With Asthma. Chest. 2019 12; 156(6):1068-1079.
    View in: PubMed
    Score: 0.055
  55. A genome-wide association study of bronchodilator response in asthmatics. Pharmacogenomics J. 2014 Feb; 14(1):41-7.
    View in: PubMed
    Score: 0.035
  56. HLA-DQ strikes again: genome-wide association study further confirms HLA-DQ in the diagnosis of asthma among adults. Clin Exp Allergy. 2012 Dec; 42(12):1724-33.
    View in: PubMed
    Score: 0.034
  57. Association of SERPINE2 with asthma. Chest. 2011 Sep; 140(3):667-674.
    View in: PubMed
    Score: 0.030
  58. MMP12, lung function, and COPD in high-risk populations. N Engl J Med. 2009 Dec 31; 361(27):2599-608.
    View in: PubMed
    Score: 0.028
  59. Parsing the effects of individual SNPs in candidate genes with family data. Hum Hered. 2010; 69(2):91-103.
    View in: PubMed
    Score: 0.028
  60. Impact of population stratification on family-based association tests with longitudinal measurements. Stat Appl Genet Mol Biol. 2009; 8:Article 17.
    View in: PubMed
    Score: 0.026
  61. Comprehensive testing of positionally cloned asthma genes in two populations. Am J Respir Crit Care Med. 2007 Nov 01; 176(9):849-57.
    View in: PubMed
    Score: 0.024
  62. The association of a SNP upstream of INSIG2 with body mass index is reproduced in several but not all cohorts. PLoS Genet. 2007 Apr 27; 3(4):e61.
    View in: PubMed
    Score: 0.023
  63. The SERPINE2 gene is associated with chronic obstructive pulmonary disease. Proc Am Thorac Soc. 2006 Aug; 3(6):502.
    View in: PubMed
    Score: 0.022
  64. The SERPINE2 gene is associated with chronic obstructive pulmonary disease. Am J Hum Genet. 2006 Feb; 78(2):253-64.
    View in: PubMed
    Score: 0.021
  65. Paternal history of asthma and airway responsiveness in children with asthma. Am J Respir Crit Care Med. 2005 Sep 01; 172(5):552-8.
    View in: PubMed
    Score: 0.020
  66. Attempted replication of reported chronic obstructive pulmonary disease candidate gene associations. Am J Respir Cell Mol Biol. 2005 Jul; 33(1):71-8.
    View in: PubMed
    Score: 0.020
  67. Genome-wide linkage of forced mid-expiratory flow in chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2004 Dec 15; 170(12):1294-301.
    View in: PubMed
    Score: 0.019
  68. The transforming growth factor-beta1 (TGFB1) gene is associated with chronic obstructive pulmonary disease (COPD). Hum Mol Genet. 2004 Aug 01; 13(15):1649-56.
    View in: PubMed
    Score: 0.019
Connection Strength
The connection strength for co-authors is the sum of the scores for each of their shared publications.

Publication scores are based on many factors, including how long ago they were written and whether the person is a first or senior author.
Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.