Harvard Catalyst Profiles

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Christoph Lange, PH.D.

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Other Positions
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Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01HG008976 (LANGE, CHRISTOPH) Sep 27, 2016 - Jun 30, 2019
    NIH/NHGRI
    Preparing Association Analysis Software Tools for Next Generation Sequencing Data
    Role: Principal Investigator
  2. P01HL132825 (WEISS, SCOTT T) Sep 1, 2016 - Jul 31, 2021
    NIH/NHLBI
    Systems Biology of Airway Disease
    Role: Co-Principal Investigator
  3. R01MH087590 (LANGE, CHRISTOPH) Dec 1, 2009 - Nov 30, 2014
    NIH/NIMH
    A New Approach to Mental Health Phenotypes in Family Genomewide Association
    Role: Principal Investigator
  4. R01MH081862 (LANGE, CHRISTOPH) Dec 1, 2007 - Mar 31, 2015
    NIH/NIMH
    Novel Statistical Approaches to Mental Health Phenotype Analysis in GWA Studies
    Role: Principal Investigator
  5. P01HL083069 (WEISS, SCOTT T) Mar 23, 2007 - Jan 31, 2014
    NIH/NHLBI
    Common Genetic Determinants of Asthma and COPD-PROGRAM PROJECT
    Role: Co-Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Ragland MF, Benway CJ, Lutz SM, Bowler RP, Hecker J, Hokanson JE, Crapo JD, Castaldi PJ, DeMeo DL, Hersh CP, Hobbs BD, Lange C, Beaty TH, Cho MH, Silverman EK. Genetic Advances in COPD: Insights from COPDGene. Am J Respir Crit Care Med. 2019 Mar 25. PMID: 30908940.
    Citations:    
  2. Hecker J, Laird N, Lange C. A comparison of popular TDT-generalizations for family-based association analysis. Genet Epidemiol. 2019 04; 43(3):300-317. PMID: 30609057.
    Citations:    Fields:    
  3. van Leth F, Brinkmann F, Cirillo DM, Dheda K, Duarte R, Guglielmetti L, Kuksa L, Lange C, Mitnick C, Skrahina A, Zaman K, Bothamley G. The Tuberculosis Network European Trials group (TBnet) ERS Clinical Research Collaboration: addressing drug-resistant tuberculosis through European cooperation. Eur Respir J. 2019 Jan; 53(1). PMID: 30606765.
    Citations:    Fields:    
  4. Lange C, Chesov D, Heyckendorf J. Clofazimine for the treatment of multidrug-resistant tuberculosis. Clin Microbiol Infect. 2019 02; 25(2):128-130. PMID: 30472423.
    Citations:    Fields:    
  5. Lange C, Chesov D, Furin J, Udwadia Z, Dheda K. Revising the definition of extensively drug-resistant tuberculosis. Lancet Respir Med. 2018 12; 6(12):893-895. PMID: 30420247.
    Citations:    Fields:    
  6. Qiao D, Ameli A, Prokopenko D, Chen H, Kho AT, Parker MM, Morrow J, Hobbs BD, Liu Y, Beaty TH, Crapo JD, Barnes KC, Nickerson DA, Bamshad M, Hersh CP, Lomas DA, Agusti A, Make BJ, Calverley PMA, Donner CF, Wouters EF, Vestbo J, Paré PD, Levy RD, Rennard SI, Tal-Singer R, Spitz MR, Sharma A, Ruczinski I, Lange C, Silverman EK, Cho MH. Whole exome sequencing analysis in severe chronic obstructive pulmonary disease. Hum Mol Genet. 2018 11 01; 27(21):3801-3812. PMID: 30060175.
    Citations:    Fields:    
  7. Prokopenko D, Sakornsakolpat P, Fier HL, Qiao D, Parker MM, McDonald MN, Manichaikul A, Rich SS, Barr RG, Williams CJ, Brantly ML, Lange C, Beaty TH, Crapo JD, Silverman EK, Cho MH. Whole-Genome Sequencing in Severe Chronic Obstructive Pulmonary Disease. Am J Respir Cell Mol Biol. 2018 Nov; 59(5):614-622. PMID: 29949718.
    Citations:    Fields:    
  8. Ahmad N, Ahuja SD, Akkerman OW, Alffenaar JC, Anderson LF, Baghaei P, Bang D, Barry PM, Bastos ML, Behera D, Benedetti A, Bisson GP, Boeree MJ, Bonnet M, Brode SK, Brust JCM, Cai Y, Caumes E, Cegielski JP, Centis R, Chan PC, Chan ED, Chang KC, Charles M, Cirule A, Dalcolmo MP, D'Ambrosio L, de Vries G, Dheda K, Esmail A, Flood J, Fox GJ, Fréchet-Jachym M, Fregona G, Gayoso R, Gegia M, Gler MT, Gu S, Guglielmetti L, Holtz TH, Hughes J, Isaakidis P, Jarlsberg L, Kempker RR, Keshavjee S, Khan FA, Kipiani M, Koenig SP, Koh WJ, Kritski A, Kuksa L, Kvasnovsky CL, Kwak N, Lan Z, Lange C, Laniado-Laborín R, Lee M, Leimane V, Leung CC, Leung EC, Li PZ, Lowenthal P, Maciel EL, Marks SM, Mase S, Mbuagbaw L, Migliori GB, Milanov V, Miller AC, Mitnick CD, Modongo C, Mohr E, Monedero I, Nahid P, Ndjeka N, O'Donnell MR, Padayatchi N, Palmero D, Pape JW, Podewils LJ, Reynolds I, Riekstina V, Robert J, Rodriguez M, Seaworth B, Seung KJ, Schnippel K, Shim TS, Singla R, Smith SE, Sotgiu G, Sukhbaatar G, Tabarsi P, Tiberi S, Trajman A, Trieu L, Udwadia ZF, van der Werf TS, Veziris N, Viiklepp P, Vilbrun SC, Walsh K, Westenhouse J, Yew WW, Yim JJ, Zetola NM, Zignol M, Menzies D. Treatment correlates of successful outcomes in pulmonary multidrug-resistant tuberculosis: an individual patient data meta-analysis. Lancet. 2018 09 08; 392(10150):821-834. PMID: 30215381.
    Citations:    Fields:    Translation:Humans
  9. Lange C, Sommerfeld M, Namsolleck P, Kintscher U, Unger T, Kaschina E. AT2R (Angiotensin AT2 Receptor) Agonist, Compound 21, Prevents Abdominal Aortic Aneurysm Progression in the Rat. Hypertension. 2018 09; 72(3):e20-e29. PMID: 29987108.
    Citations:    Fields:    
  10. Günther G, van Leth F, Alexandru S, Altet N, Avsar K, Bang D, Barbuta R, Bothamley G, Ciobanu A, Crudu V, Danilovits M, Dedicoat M, Duarte R, Gualano G, Kunst H, de Lange W, Leimane V, McLaughlin AM, Magis-Escurra C, Muylle I, Polcová V, Popa C, Rumetshofer R, Skrahina A, Solodovnikova V, Spinu V, Tiberi S, Viiklepp P, Lange C. Clinical Management of Multidrug-Resistant Tuberculosis in 16 European Countries. Am J Respir Crit Care Med. 2018 Aug 01; 198(3):379-386. PMID: 29509468.
    Citations:    Fields:    
  11. Salzer HJF, Stoney RJ, Angelo KM, Rolling T, Grobusch MP, Libman M, López-Vélez R, Duvignaud A, Ásgeirsson H, Crespillo-Andújar C, Schwartz E, Gautret P, Bottieau E, Jordan S, Lange C, Hamer DH. Epidemiological aspects of travel-related systemic endemic mycoses: a GeoSentinel analysis, 1997-2017. J Travel Med. 2018 08 01; 25(1). PMID: 30085265.
    Citations:    Fields:    
  12. Salzer HJF, Kuempers C, Pasternack H, Heyckendorf J, Bialek R, Palade E, Hundack L, Kalsdorf B, Lange C. An Unexpected Endobronchial Mass Appearing During Bronchoscopy. Chest. 2018 Jul; 154(1):e13-e21. PMID: 30044749.
    Citations:    Fields:    
  13. Hecker J, Prokopenko D, Lange C, Fier HL. PolyGEE: a generalized estimating equation approach to the efficient and robust estimation of polygenic effects in large-scale association studies. Biostatistics. 2018 07 01; 19(3):295-306. PMID: 28968646.
    Citations: 1     Fields:    
  14. Lange C, van Leth F, Mitnick CD, Dheda K, Günther G. Time to revise WHO-recommended definitions of MDR-TB treatment outcomes. Lancet Respir Med. 2018 04; 6(4):246-248. PMID: 29595505.
    Citations:    Fields:    Translation:Humans
  15. Dheda K, Gumbo T, Lange C, Horsburgh CR, Furin J. Pan-tuberculosis regimens: an argument against. Lancet Respir Med. 2018 04; 6(4):240-242. PMID: 29595502.
    Citations:    Fields:    Translation:HumansCells
  16. van Ingen J, Aksamit T, Andrejak C, Böttger EC, Cambau E, Daley CL, Griffith DE, Guglielmetti L, Holland SM, Huitt GA, Koh WJ, Lange C, Leitman P, Marras TK, Morimoto K, Olivier KN, Santin M, Stout JE, Thomson R, Tortoli E, Wallace RJ, Winthrop KL, Wagner D. Treatment outcome definitions in nontuberculous mycobacterial pulmonary disease: an NTM-NET consensus statement. Eur Respir J. 2018 03; 51(3). PMID: 29567726.
    Citations: 2     Fields:    
  17. Hecker J, Xu X, Townes FW, Loehlein Fier H, Corcoran C, Laird N, Lange C. Family-based tests for associating haplotypes with general phenotype data: Improving the FBAT-haplotype algorithm. Genet Epidemiol. 2018 02; 42(1):123-126. PMID: 29159827.
    Citations:    Fields:    Translation:Humans
  18. Schlauch D, Fier H, Lange C. Identification of genetic outliers due to sub-structure and cryptic relationships. Bioinformatics. 2017 Jul 01; 33(13):1972-1979. PMID: 28334167.
    Citations:    Fields:    Translation:Humans
  19. Hecker J, Maaser A, Prokopenko D, Fier HL, Lange C. Reporting Correct p Values in VEGAS Analyses. Twin Res Hum Genet. 2017 06; 20(3):257-259. PMID: 28345502.
    Citations: 2     Fields:    Translation:Humans
  20. Loehlein Fier H, Prokopenko D, Hecker J, Cho MH, Silverman EK, Weiss ST, Tanzi RE, Lange C. On the association analysis of genome-sequencing data: A spatial clustering approach for partitioning the entire genome into nonoverlapping windows. Genet Epidemiol. 2017 05; 41(4):332-340. PMID: 28318110.
    Citations: 1     Fields:    Translation:Humans
  21. Dheda K, Gumbo T, Maartens G, Dooley KE, McNerney R, Murray M, Furin J, Nardell EA, London L, Lessem E, Theron G, van Helden P, Niemann S, Merker M, Dowdy D, Van Rie A, Siu GK, Pasipanodya JG, Rodrigues C, Clark TG, Sirgel FA, Esmail A, Lin HH, Atre SR, Schaaf HS, Chang KC, Lange C, Nahid P, Udwadia ZF, Horsburgh CR, Churchyard GJ, Menzies D, Hesseling AC, Nuermberger E, McIlleron H, Fennelly KP, Goemaere E, Jaramillo E, Low M, Jara CM, Padayatchi N, Warren RM. The epidemiology, pathogenesis, transmission, diagnosis, and management of multidrug-resistant, extensively drug-resistant, and incurable tuberculosis. Lancet Respir Med. 2017 Mar 15. PMID: 28344011.
    Citations: 39     Fields:    
  22. Qiao D, Lange C, Laird NM, Won S, Hersh CP, Morrow J, Hobbs BD, Lutz SM, Ruczinski I, Beaty TH, Silverman EK, Cho MH. Gene-based segregation method for identifying rare variants in family-based sequencing studies. Genet Epidemiol. 2017 05; 41(4):309-319. PMID: 28191685.
    Citations: 3     Fields:    Translation:Humans
  23. McDonald MN, Won S, Mattheisen M, Castaldi PJ, Cho MH, Rutten E, Hardin M, Yip WK, Rennard SI, Lomas DA, Wouters EFM, Agusti A, Casaburi R, Lange CP, O'Connor G, Hersh CP, Silverman EK. Body mass index change in gastrointestinal cancer and chronic obstructive pulmonary disease is associated with Dedicator of Cytokinesis 1. J Cachexia Sarcopenia Muscle. 2017 Jun; 8(3):428-436. PMID: 28044437.
    Citations: 1     Fields:    Translation:Humans
  24. Lutz SM, Fingerlin TE, Hokanson JE, Lange C. A general approach to testing for pleiotropy with rare and common variants. Genet Epidemiol. 2017 Feb; 41(2):163-170. PMID: 27900789.
    Citations: 3     Fields:    Translation:Humans
  25. Busch M, Herzmann C, Kallert S, Zimmermann A, Höfer C, Mayer D, Zenk SF, Muche R, Lange C, Bloom BR, Modlin RL, Stenger S. Lipoarabinomannan-Responsive Polycytotoxic T Cells Are Associated with Protection in Human Tuberculosis. Am J Respir Crit Care Med. 2016 08 01; 194(3):345-55. PMID: 26882070.
    Citations: 9     Fields:    Translation:HumansCells
  26. Olaru ID, Lange C, Indra A, Meidlinger L, Huhulescu S, Rumetshofer R. High Rates of Treatment Success in Pulmonary Multidrug-Resistant Tuberculosis by Individually Tailored Treatment Regimens. Ann Am Thorac Soc. 2016 08; 13(8):1271-8. PMID: 27163360.
    Citations: 3     Fields:    Translation:Humans
  27. Qiao D, Lange C, Beaty TH, Crapo JD, Barnes KC, Bamshad M, Hersh CP, Morrow J, Pinto-Plata VM, Marchetti N, Bueno R, Celli BR, Criner GJ, Silverman EK, Cho MH. Exome Sequencing Analysis in Severe, Early-Onset Chronic Obstructive Pulmonary Disease. Am J Respir Crit Care Med. 2016 06 15; 193(12):1353-63. PMID: 26736064.
    Citations: 12     Fields:    Translation:Humans
  28. Mitnick CD, Rodriguez CA, Hatton ML, Brigden G, Cobelens F, Grobusch MP, Horsburgh R, Lange C, Lienhardt C, Oren E, Podewils LJ, Seaworth B, van den Hof S, Daley CL, Gebhard AC, Wares F. Programmatic Management of Drug-Resistant Tuberculosis: An Updated Research Agenda. PLoS One. 2016; 11(5):e0155968. PMID: 27223622.
    Citations: 1     Fields:    Translation:Humans
  29. Lange C, van Leth F, Sester M. Viral Load and Risk of Tuberculosis in HIV Infection. J Acquir Immune Defic Syndr. 2016 Feb 01; 71(2):e51-3. PMID: 26761521.
    Citations: 2     Fields:    Translation:HumansCells
  30. Lange C, Mandalakas AM, Kalsdorf B, Denkinger CM, Sester M. Clinical Application of Interferon-? Release Assays for the Prevention of Tuberculosis in Countries with Low Incidence. Pathog Immun. 2016; 1(2):308-329. PMID: 28217762.
    Citations: 1     
  31. Prokopenko D, Hecker J, Silverman EK, Pagano M, Nöthen MM, Dina C, Lange C, Fier HL. Utilizing the Jaccard index to reveal population stratification in sequencing data: a simulation study and an application to the 1000 Genomes Project. Bioinformatics. 2016 05 01; 32(9):1366-72. PMID: 26722118.
    Citations: 3     Fields:    Translation:HumansAnimals
  32. Hecker J, Prokopenko D, Lange C, Fier HL. On the Recombination Rate Estimation in the Presence of Population Substructure. PLoS One. 2015; 10(12):e0145152. PMID: 26716445.
    Citations:    Fields:    Translation:Humans
  33. Lutz SM, Cho MH, Young K, Hersh CP, Castaldi PJ, McDonald ML, Regan E, Mattheisen M, DeMeo DL, Parker M, Foreman M, Make BJ, Jensen RL, Casaburi R, Lomas DA, Bhatt SP, Bakke P, Gulsvik A, Crapo JD, Beaty TH, Laird NM, Lange C, Hokanson JE, Silverman EK. A genome-wide association study identifies risk loci for spirometric measures among smokers of European and African ancestry. BMC Genet. 2015 Dec 03; 16:138. PMID: 26634245.
    Citations: 12     Fields:    Translation:HumansCellsCTClinical Trials
  34. Park S, Lee S, Lee Y, Herold C, Hooli B, Mullin K, Park T, Park C, Bertram L, Lange C, Tanzi R, Won S. Adjusting heterogeneous ascertainment bias for genetic association analysis with extended families. BMC Med Genet. 2015 Aug 19; 16:62. PMID: 26286599.
    Citations: 2     Fields:    Translation:Humans
  35. Prokopenko D, Hecker J, Silverman E, Nöthen MM, Schmid M, Lange C, Loehlein Fier H. Using Network Methodology to Infer Population Substructure. PLoS One. 2015; 10(6):e0130708. PMID: 26098940.
    Citations:    Fields:    Translation:Humans
  36. Zhou JJ, Cho MH, Lange C, Lutz S, Silverman EK, Laird NM. Integrating Multiple Correlated Phenotypes for Genetic Association Analysis by Maximizing Heritability. Hum Hered. 2015; 79(2):93-104. PMID: 26111731.
    Citations: 5     Fields:    Translation:Humans
  37. Basmanav FB, Forstner AJ, Fier H, Herms S, Meier S, Degenhardt F, Hoffmann P, Barth S, Fricker N, Strohmaier J, Witt SH, Ludwig M, Schmael C, Moebus S, Maier W, Mössner R, Rujescu D, Rietschel M, Lange C, Nöthen MM, Cichon S. Investigation of the role of TCF4 rare sequence variants in schizophrenia. Am J Med Genet B Neuropsychiatr Genet. 2015 Jul; 168B(5):354-62. PMID: 26010163.
    Citations: 1     Fields:    Translation:Humans
  38. Zellweger JP, Sotgiu G, Block M, Dore S, Altet N, Blunschi R, Bogyi M, Bothamley G, Bothe C, Codecasa L, Costa P, Dominguez J, Duarte R, Fløe A, Fresard I, García-García JM, Goletti D, Halm P, Hellwig D, Henninger E, Heykes-Uden H, Horn L, Kruczak K, Latorre I, Pache G, Rath H, Ringshausen FC, Ruiz AS, Solovic I, Souza-Galvão ML, Widmer U, Witte P, Lange C. Risk Assessment of Tuberculosis in Contacts by IFN-? Release Assays. A Tuberculosis Network European Trials Group Study. Am J Respir Crit Care Med. 2015 May 15; 191(10):1176-84. PMID: 25763458.
    Citations: 20     Fields:    Translation:HumansCellsPHPublic Health
  39. Hooli BV, Lill CM, Mullin K, Qiao D, Lange C, Bertram L, Tanzi RE. PLD3 gene variants and Alzheimer's disease. Nature. 2015 Apr 02; 520(7545):E7-8. PMID: 25832413.
    Citations: 16     Fields:    Translation:Humans
  40. Sester M, van Leth F, Bruchfeld J, Bumbacea D, Cirillo DM, Dilektasli AG, Domínguez J, Duarte R, Ernst M, Eyuboglu FO, Gerogianni I, Girardi E, Goletti D, Janssens JP, Julander I, Lange B, Latorre I, Losi M, Markova R, Matteelli A, Milburn H, Ravn P, Scholman T, Soccal PM, Straub M, Wagner D, Wolf T, Yalcin A, Lange C. Risk assessment of tuberculosis in immunocompromised patients. A TBNET study. Am J Respir Crit Care Med. 2014 Nov 15; 190(10):1168-76. PMID: 25303140.
    Citations: 27     Fields:    Translation:Humans
  41. Günther G, Gomez GB, Lange C, Rupert S, van Leth F. Availability, price and affordability of anti-tuberculosis drugs in Europe: a TBNET survey. Eur Respir J. 2015 Apr; 45(4):1081-8. PMID: 25395035.
    Citations: 5     Fields:    Translation:Humans
  42. Gutsfeld C, Olaru ID, Vollrath O, Lange C. Attitudes about tuberculosis prevention in the elimination phase: a survey among physicians in Germany. PLoS One. 2014; 9(11):e112681. PMID: 25393241.
    Citations: 4     Fields:    Translation:HumansCellsPHPublic Health
  43. McDonald ML, Cho MH, Sørheim IC, Lutz SM, Castaldi PJ, Lomas DA, Coxson HO, Edwards LD, MacNee W, Vestbo J, Yates JC, Agusti A, Calverley PM, Celli B, Crim C, Rennard SI, Wouters EF, Bakke P, Tal-Singer R, Miller BE, Gulsvik A, Casaburi R, Wells JM, Regan EA, Make BJ, Hokanson JE, Lange C, Crapo JD, Beaty TH, Silverman EK, Hersh CP. Common genetic variants associated with resting oxygenation in chronic obstructive pulmonary disease. Am J Respir Cell Mol Biol. 2014 Nov; 51(5):678-87. PMID: 24825563.
    Citations: 6     Fields:    Translation:HumansCellsCTClinical Trials
  44. Castaldi PJ, Cho MH, Zhou X, Qiu W, Mcgeachie M, Celli B, Bakke P, Gulsvik A, Lomas DA, Crapo JD, Beaty TH, Rennard S, Harshfield B, Lange C, Singh D, Tal-Singer R, Riley JH, Quackenbush J, Raby BA, Carey VJ, Silverman EK, Hersh CP. Genetic control of gene expression at novel and established chronic obstructive pulmonary disease loci. Hum Mol Genet. 2015 Feb 15; 24(4):1200-10. PMID: 25315895.
    Citations: 13     Fields:    Translation:HumansCells
  45. Yip WK, Fier H, DeMeo DL, Aryee M, Laird N, Lange C. A novel method for detecting association between DNA methylation and diseases using spatial information. Genet Epidemiol. 2014 Dec; 38(8):714-21. PMID: 25250875.
    Citations: 2     Fields:    Translation:HumansCells
  46. Hooli BV, Parrado AR, Mullin K, Yip WK, Liu T, Roehr JT, Qiao D, Jessen F, Peters O, Becker T, Ramirez A, Lange C, Bertram L, Tanzi RE. The rare TREM2 R47H variant exerts only a modest effect on Alzheimer disease risk. Neurology. 2014 Oct 07; 83(15):1353-8. PMID: 25186855.
    Citations: 12     Fields:    Translation:Humans
  47. Blauenfeldt T, Heyckendorf J, Graff Jensen S, Lange C, Drabe C, Hermansen TS, de Thurah L, Lillebaek T, Eugen-Olsen J, Seersholm N, Hoff S, Bonde J, Ruhwald M. Development of a one-step probe based molecular assay for rapid immunodiagnosis of infection with M. tuberculosis using dried blood spots. PLoS One. 2014; 9(9):e105628. PMID: 25184553.
    Citations: 2     Fields:    Translation:HumansCells
  48. McDonald ML, Mattheisen M, Cho MH, Liu YY, Harshfield B, Hersh CP, Bakke P, Gulsvik A, Lange C, Beaty TH, Silverman EK. Beyond GWAS in COPD: probing the landscape between gene-set associations, genome-wide associations and protein-protein interaction networks. Hum Hered. 2014; 78(3-4):131-9. PMID: 25171373.
    Citations: 5     Fields:    Translation:Humans
  49. Essone PN, Kalsdorf B, Chegou NN, Loxton AG, Kriel M, Preyer R, Ernst M, Walzl G, Lange C. Bifunctional T-cell-derived cytokines for the diagnosis of tuberculosis and treatment monitoring. Respiration. 2014; 88(3):251-61. PMID: 25171202.
    Citations: 5     Fields:    Translation:HumansCells
  50. Choi S, Lee S, Cichon S, Nöthen MM, Lange C, Park T, Won S. FARVAT: a family-based rare variant association test. Bioinformatics. 2014 Nov 15; 30(22):3197-205. PMID: 25075118.
    Citations: 7     Fields:    Translation:Humans
  51. Lutz SM, Hokanson JE, Lange C. An alternative hypothesis testing strategy for secondary phenotype data in case-control genetic association studies. Front Genet. 2014; 5:188. PMID: 25071819.
    Citations: 5     
  52. Juraeva D, Haenisch B, Zapatka M, Frank J, Witt SH, Mühleisen TW, Treutlein J, Strohmaier J, Meier S, Degenhardt F, Giegling I, Ripke S, Leber M, Lange C, Schulze TG, Mössner R, Nenadic I, Sauer H, Rujescu D, Maier W, Børglum A, Ophoff R, Cichon S, Nöthen MM, Rietschel M, Mattheisen M, Brors B. Integrated pathway-based approach identifies association between genomic regions at CTCF and CACNB2 and schizophrenia. PLoS Genet. 2014 Jun; 10(6):e1004345. PMID: 24901509.
    Citations: 14     Fields:    Translation:HumansCells
  53. Mattheisen M, Samuels JF, Wang Y, Greenberg BD, Fyer AJ, McCracken JT, Geller DA, Murphy DL, Knowles JA, Grados MA, Riddle MA, Rasmussen SA, McLaughlin NC, Nurmi EL, Askland KD, Qin HD, Cullen BA, Piacentini J, Pauls DL, Bienvenu OJ, Stewart SE, Liang KY, Goes FS, Maher B, Pulver AE, Shugart YY, Valle D, Lange C, Nestadt G. Genome-wide association study in obsessive-compulsive disorder: results from the OCGAS. Mol Psychiatry. 2015 Mar; 20(3):337-44. PMID: 24821223.
    Citations: 53     Fields:    Translation:HumansCells
  54. Al Chawa T, Ludwig KU, Fier H, Pötzsch B, Reich RH, Schmidt G, Braumann B, Daratsianos N, Böhmer AC, Schuencke H, Alblas M, Fricker N, Hoffmann P, Knapp M, Lange C, Nöthen MM, Mangold E. Nonsyndromic cleft lip with or without cleft palate: Increased burden of rare variants within Gremlin-1, a component of the bone morphogenetic protein 4 pathway. Birth Defects Res A Clin Mol Teratol. 2014 Jun; 100(6):493-8. PMID: 24706492.
    Citations: 5     Fields:    Translation:HumansCells
  55. Kaufmann SH, Lange C, Rao M, Balaji KN, Lotze M, Schito M, Zumla AI, Maeurer M. Progress in tuberculosis vaccine development and host-directed therapies--a state of the art review. Lancet Respir Med. 2014 Apr; 2(4):301-20. PMID: 24717627.
    Citations: 58     Fields:    Translation:HumansCells
  56. McDonald ML, Diaz AA, Ross JC, San Jose Estepar R, Zhou L, Regan EA, Eckbo E, Muralidhar N, Come CE, Cho MH, Hersh CP, Lange C, Wouters E, Casaburi RH, Coxson HO, Macnee W, Rennard SI, Lomas DA, Agusti A, Celli BR, Black-Shinn JL, Kinney GL, Lutz SM, Hokanson JE, Silverman EK, Washko GR. Quantitative computed tomography measures of pectoralis muscle area and disease severity in chronic obstructive pulmonary disease. A cross-sectional study. Ann Am Thorac Soc. 2014 Mar; 11(3):326-34. PMID: 24558953.
    Citations: 19     Fields:    Translation:Humans
  57. Cho MH, McDonald ML, Zhou X, Mattheisen M, Castaldi PJ, Hersh CP, Demeo DL, Sylvia JS, Ziniti J, Laird NM, Lange C, Litonjua AA, Sparrow D, Casaburi R, Barr RG, Regan EA, Make BJ, Hokanson JE, Lutz S, Dudenkov TM, Farzadegan H, Hetmanski JB, Tal-Singer R, Lomas DA, Bakke P, Gulsvik A, Crapo JD, Silverman EK, Beaty TH. Risk loci for chronic obstructive pulmonary disease: a genome-wide association study and meta-analysis. Lancet Respir Med. 2014 Mar; 2(3):214-25. PMID: 24621683.
    Citations: 77     Fields:    Translation:Humans
  58. Won S, Kim Y, Lange C. On rare-variant analysis in population-based designs: decomposing the likelihood to two informative components. Hum Hered. 2013; 76(2):76-85. PMID: 24434864.
    Citations:    Fields:    Translation:Humans
  59. Won S, Kwon MS, Mattheisen M, Park S, Park C, Kihara D, Cichon S, Ophoff R, Nöthen MM, Rietschel M, Baur M, Uitterlinden AG, Hofmann A, Lange C. Efficient strategy for detecting gene × gene joint action and its application in schizophrenia. Genet Epidemiol. 2014 Jan; 38(1):60-71. PMID: 24272960.
    Citations: 3     Fields:    Translation:Humans
  60. Lutz SM, Vansteelandt S, Lange C. Testing for direct genetic effects using a screening step in family-based association studies. Front Genet. 2013; 4:243. PMID: 24312120.
    Citations: 2     
  61. Qiao D, Cho MH, Fier H, Bakke PS, Gulsvik A, Silverman EK, Lange C. On the simultaneous association analysis of large genomic regions: a massive multi-locus association test. Bioinformatics. 2014 Jan 15; 30(2):157-64. PMID: 24262215.
    Citations: 1     Fields:    Translation:HumansCells
  62. Swanson DM, Blacker D, Alchawa T, Ludwig KU, Mangold E, Lange C. Properties of permutation-based gene tests and controlling type 1 error using a summary statistic based gene test. BMC Genet. 2013 Nov 07; 14:108. PMID: 24199751.
    Citations: 2     Fields:    Translation:Humans
  63. Chang SC, Pauls DL, Lange C, Sasanfar R, Santangelo SL. Sex-specific association of a common variant of the XG gene with autism spectrum disorders. Am J Med Genet B Neuropsychiatr Genet. 2013 Oct; 162B(7):742-50. PMID: 24132906.
    Citations: 5     Fields:    Translation:Humans
  64. Hooli BV, Kovacs-Vajna ZM, Mullin K, Blumenthal MA, Mattheisen M, Zhang C, Lange C, Mohapatra G, Bertram L, Tanzi RE. Rare autosomal copy number variations in early-onset familial Alzheimer's disease. Mol Psychiatry. 2014 Jun; 19(6):676-81. PMID: 23752245.
    Citations: 19     Fields:    Translation:Humans
  65. Won S, Lange C. A general framework for robust and efficient association analysis in family-based designs: quantitative and dichotomous phenotypes. Stat Med. 2013 Nov 10; 32(25):4482-98. PMID: 23740776.
    Citations: 6     Fields:    Translation:Humans
  66. Qiao D, Mattheisen M, Lange C. On association analysis of rare variants under population substructure: an approach for the detection of subjects that can cause bias in the analysis--T opt: an outlier detection method. Genet Epidemiol. 2013 Jul; 37(5):431-9. PMID: 23674291.
    Citations:    Fields:    Translation:Humans
  67. Fung WL, Naylor MG, Bennett DA, Lange C, Blacker D. Principal components methods for narrow-sense heritability in the analysis of multidimensional longitudinal cognitive phenotypes. Am J Med Genet B Neuropsychiatr Genet. 2013 Oct; 162B(7):770-8. PMID: 23650207.
    Citations: 1     Fields:    Translation:Humans
  68. Liang F, Bond E, Sandgren KJ, Smed-Sörensen A, Rangaka MX, Lange C, Koup RA, McComsey GA, Lederman MM, Wilkinson RJ, Andersson J, Loré K. Dendritic cell recruitment in response to skin antigen tests in HIV-1-infected individuals correlates with the level of T-cell infiltration. AIDS. 2013 Apr 24; 27(7):1071-80. PMID: 23324660.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  69. Duan QL, Lasky-Su J, Himes BE, Qiu W, Litonjua AA, Damask A, Lazarus R, Klanderman B, Irvin CG, Peters SP, Hanrahan JP, Lima JJ, Martinez FD, Mauger D, Chinchilli VM, Soto-Quiros M, Avila L, Celedón JC, Lange C, Weiss ST, Tantisira KG. A genome-wide association study of bronchodilator response in asthmatics. Pharmacogenomics J. 2014 Feb; 14(1):41-7. PMID: 23508266.
    Citations: 6     Fields:    Translation:Humans
  70. Maslova E, Strøm M, Oken E, Campos H, Lange C, Gold D, Olsen SF. Fish intake during pregnancy and the risk of child asthma and allergic rhinitis - longitudinal evidence from the Danish National Birth Cohort. Br J Nutr. 2013 Oct; 110(7):1313-25. PMID: 23473120.
    Citations: 5     Fields:    Translation:HumansAnimals
  71. Lutz S, Yip WK, Hokanson J, Laird N, Lange C. A general semi-parametric approach to the analysis of genetic association studies in population-based designs. BMC Genet. 2013 Feb 28; 14:13. PMID: 23448186.
    Citations:    Fields:    Translation:Humans
  72. Siedlinski M, Tingley D, Lipman PJ, Cho MH, Litonjua AA, Sparrow D, Bakke P, Gulsvik A, Lomas DA, Anderson W, Kong X, Rennard SI, Beaty TH, Hokanson JE, Crapo JD, Lange C, Silverman EK. Dissecting direct and indirect genetic effects on chronic obstructive pulmonary disease (COPD) susceptibility. Hum Genet. 2013 Apr; 132(4):431-41. PMID: 23299987.
    Citations: 21     Fields:    Translation:HumansCTClinical Trials
  73. Kalsdorf B, Skolimowska KH, Scriba TJ, Dawson R, Dheda K, Wood K, Hofmeister J, Hanekom WA, Lange C, Wilkinson RJ. Relationship between chemokine receptor expression, chemokine levels and HIV-1 replication in the lungs of persons exposed to Mycobacterium tuberculosis. Eur J Immunol. 2013 Feb; 43(2):540-9. PMID: 23147374.
    Citations: 5     Fields:    Translation:HumansCells
  74. Lasky-Su J, Himes BE, Raby BA, Klanderman BJ, Sylvia JS, Lange C, Melen E, Martinez FD, Israel E, Gauderman J, Gilliland F, Sleiman P, Hakonarson H, Celedón JC, Soto-Quiros M, Avila L, Lima JJ, Irvin CG, Peters SP, Boushey H, Chinchilli VM, Mauger D, Tantisira K, Weiss ST. HLA-DQ strikes again: genome-wide association study further confirms HLA-DQ in the diagnosis of asthma among adults. Clin Exp Allergy. 2012 Dec; 42(12):1724-33. PMID: 23181788.
    Citations: 15     Fields:    Translation:Humans
  75. Nasser E, Mangold E, Tradowsky DC, Fier H, Becker J, Boehmer AC, Herberz R, Fricker N, Barth S, Wahle P, Nowak S, Reutter H, Reich RH, Lauster C, Braumann B, Kreusch T, Hemprich A, Pötzsch B, Hoffmann P, Kramer FJ, Knapp M, Lange C, Nöthen MM, Ludwig KU. Resequencing of VAX1 in patients with nonsyndromic cleft lip with or without cleft palate. Birth Defects Res A Clin Mol Teratol. 2012 Nov; 94(11):925-33. PMID: 23081944.
    Citations: 5     Fields:    Translation:HumansCells
  76. Fier H, Won S, Prokopenko D, AlChawa T, Ludwig KU, Fimmers R, Silverman EK, Pagano M, Mangold E, Lange C. 'Location, Location, Location': a spatial approach for rare variant analysis and an application to a study on non-syndromic cleft lip with or without cleft palate. Bioinformatics. 2012 Dec 01; 28(23):3027-33. PMID: 23044548.
    Citations: 8     Fields:    Translation:HumansCells
  77. Ludwig KU, Mangold E, Herms S, Nowak S, Reutter H, Paul A, Becker J, Herberz R, AlChawa T, Nasser E, Böhmer AC, Mattheisen M, Alblas MA, Barth S, Kluck N, Lauster C, Braumann B, Reich RH, Hemprich A, Pötzsch S, Blaumeiser B, Daratsianos N, Kreusch T, Murray JC, Marazita ML, Ruczinski I, Scott AF, Beaty TH, Kramer FJ, Wienker TF, Steegers-Theunissen RP, Rubini M, Mossey PA, Hoffmann P, Lange C, Cichon S, Propping P, Knapp M, Nöthen MM. Genome-wide meta-analyses of nonsyndromic cleft lip with or without cleft palate identify six new risk loci. Nat Genet. 2012 Sep; 44(9):968-71. PMID: 22863734.
    Citations: 75     Fields:    Translation:Humans
  78. Vansteelandt S, Lange C. Causation and causal inference for genetic effects. Hum Genet. 2012 Oct; 131(10):1665-76. PMID: 22864952.
    Citations: 5     Fields:    Translation:Humans
  79. Qiao D, Yip WK, Lange C. Handling the data management needs of high-throughput sequencing data: SpeedGene, a compression algorithm for the efficient storage of genetic data. BMC Bioinformatics. 2012 May 16; 13:100. PMID: 22591016.
    Citations: 4     Fields:    
  80. Adhikari K, AlChawa T, Ludwig K, Mangold E, Laird N, Lange C. Is it rare or common? Genet Epidemiol. 2012 Jul; 36(5):419-29. PMID: 22549767.
    Citations: 1     Fields:    Translation:Humans
  81. Mühleisen TW, Mattheisen M, Strohmaier J, Degenhardt F, Priebe L, Schultz CC, Breuer R, Meier S, Hoffmann P, Rivandeneira F, Hofman A, Uitterlinden AG, Moebus S, Gieger C, Emeny R, Ladwig KH, Wichmann HE, Schwarz M, Kammerer-Ciernioch J, Schlösser RG, Nenadic I, Sauer H, Mössner R, Maier W, Rujescu D, Lange C, Ophoff RA, Schulze TG, Rietschel M, Nöthen MM, Cichon S. Association between schizophrenia and common variation in neurocan (NCAN), a genetic risk factor for bipolar disorder. Schizophr Res. 2012 Jun; 138(1):69-73. PMID: 22497794.
    Citations: 28     Fields:    Translation:Humans
  82. Hooli BV, Mohapatra G, Mattheisen M, Parrado AR, Roehr JT, Shen Y, Gusella JF, Moir R, Saunders AJ, Lange C, Tanzi RE, Bertram L. Role of common and rare APP DNA sequence variants in Alzheimer disease. Neurology. 2012 Apr 17; 78(16):1250-7. PMID: 22491860.
    Citations: 17     Fields:    Translation:Humans
  83. Degenhardt F, Priebe L, Herms S, Mattheisen M, Mühleisen TW, Meier S, Moebus S, Strohmaier J, Groß M, Breuer R, Lange C, Hoffmann P, Meyer-Lindenberg A, Heinz A, Walter H, Lucae S, Wolf C, Müller-Myhsok B, Holsboer F, Maier W, Rietschel M, Nöthen MM, Cichon S. Association between copy number variants in 16p11.2 and major depressive disorder in a German case-control sample. Am J Med Genet B Neuropsychiatr Genet. 2012 Apr; 159B(3):263-73. PMID: 22344817.
    Citations: 14     Fields:    Translation:HumansCells
  84. Won S, Lu Q, Bertram L, Tanzi RE, Lange C. On the meta-analysis of genome-wide association studies: a robust and efficient approach to combine population and family-based studies. Hum Hered. 2012; 73(1):35-46. PMID: 22261799.
    Citations: 3     Fields:    Translation:Humans
  85. Lipman PJ, Yip WK, AlChawa T, Ludwig KU, Mangold E, Lange C. On the analysis of sequence data: testing for disease susceptibility loci using patterns of linkage disequilibrium. Genet Epidemiol. 2011 Dec; 35(8):880-6. PMID: 22125225.
    Citations:    Fields:    Translation:Humans
  86. Sebro R, Lange C, Laird NM, Rogus JJ, Risch NJ. Differentiating population stratification from genotyping error using family data. Ann Hum Genet. 2012 Jan; 76(1):42-52. PMID: 22111716.
    Citations: 1     Fields:    Translation:Humans
  87. Cho MH, Castaldi PJ, Wan ES, Siedlinski M, Hersh CP, Demeo DL, Himes BE, Sylvia JS, Klanderman BJ, Ziniti JP, Lange C, Litonjua AA, Sparrow D, Regan EA, Make BJ, Hokanson JE, Murray T, Hetmanski JB, Pillai SG, Kong X, Anderson WH, Tal-Singer R, Lomas DA, Coxson HO, Edwards LD, MacNee W, Vestbo J, Yates JC, Agusti A, Calverley PM, Celli B, Crim C, Rennard S, Wouters E, Bakke P, Gulsvik A, Crapo JD, Beaty TH, Silverman EK. A genome-wide association study of COPD identifies a susceptibility locus on chromosome 19q13. Hum Mol Genet. 2012 Feb 15; 21(4):947-57. PMID: 22080838.
    Citations: 91     Fields:    Translation:HumansCells
  88. Tantisira KG, Lasky-Su J, Harada M, Murphy A, Litonjua AA, Himes BE, Lange C, Lazarus R, Sylvia J, Klanderman B, Duan QL, Qiu W, Hirota T, Martinez FD, Mauger D, Sorkness C, Szefler S, Lazarus SC, Lemanske RF, Peters SP, Lima JJ, Nakamura Y, Tamari M, Weiss ST. Genomewide association between GLCCI1 and response to glucocorticoid therapy in asthma. N Engl J Med. 2011 Sep 29; 365(13):1173-83. PMID: 21991891.
    Citations: 73     Fields:    Translation:Humans
  89. Andresen E, Günther G, Bullwinkel J, Lange C, Heine H. Increased expression of beta-defensin 1 (DEFB1) in chronic obstructive pulmonary disease. PLoS One. 2011; 6(7):e21898. PMID: 21818276.
    Citations: 17     Fields:    Translation:HumansCells
  90. Lipman PJ, Lange C. CGene: an R package for implementation of causal genetic analyses. Eur J Hum Genet. 2011 Dec; 19(12):1292-4. PMID: 21731061.
    Citations: 2     Fields:    Translation:Humans
  91. Uciechowski P, Imhoff H, Lange C, Meyer CG, Browne EN, Kirsten DK, Schröder AK, Schaaf B, Al-Lahham A, Reinert RR, Reiling N, Haase H, Hatzmann A, Fleischer D, Heussen N, Kleines M, Rink L. Susceptibility to tuberculosis is associated with TLR1 polymorphisms resulting in a lack of TLR1 cell surface expression. J Leukoc Biol. 2011 Aug; 90(2):377-88. PMID: 21642391.
    Citations: 29     Fields:    Translation:HumansCells
  92. Himes BE, Klanderman B, Ziniti J, Senter-Sylvia J, Soto-Quiros ME, Avila L, Celedón JC, Lange C, Mariani TJ, Lasky-Su J, Hersh CP, Raby BA, Silverman EK, Weiss ST, DeMeo DL. Association of SERPINE2 with asthma. Chest. 2011 Sep; 140(3):667-674. PMID: 21436250.
    Citations: 5     Fields:    Translation:Humans
  93. Hoffmann TJ, Vansteelandt S, Lange C, Silverman EK, DeMeo DL, Laird NM. Combining disease models to test for gene-environment interaction in nuclear families. Biometrics. 2011 Dec; 67(4):1260-70. PMID: 21401569.
    Citations: 1     Fields:    Translation:Humans
  94. Lipman PJ, Cho MH, Bakke P, Gulsvik A, Kong X, Lomas DA, Anderson W, Silverman EK, Lange C. On the follow-up of genome-wide association studies: an overall test for the most promising SNPs. Genet Epidemiol. 2011 Jul; 35(5):303-9. PMID: 21374717.
    Citations: 2     Fields:    Translation:Humans
  95. Andresen E, Lange C, Strodthoff D, Goldmann T, Fischer N, Sahly H, Branscheid D, Heine H. S100A7/psoriasin expression in the human lung: unchanged in patients with COPD, but upregulated upon positive S. aureus detection. BMC Pulm Med. 2011 Feb 15; 11:10. PMID: 21324122.
    Citations: 5     Fields:    Translation:HumansCells
  96. Ionita-Laza I, Buxbaum JD, Laird NM, Lange C. A new testing strategy to identify rare variants with either risk or protective effect on disease. PLoS Genet. 2011 Feb 03; 7(2):e1001289. PMID: 21304886.
    Citations: 82     Fields:    Translation:Humans
  97. Yip WK, Lange C. Quantitative trait prediction based on genetic marker-array data, a simulation study. Bioinformatics. 2011 Mar 15; 27(6):745-8. PMID: 21285022.
    Citations: 3     Fields:    Translation:Humans
  98. Amos CI, Lange C. Family-based designs. IARC Sci Publ. 2011; (163):261-80. PMID: 22997867.
    Citations:    Fields:    Translation:Humans
  99. Lipman PJ, Liu KY, Muehlschlegel JD, Body S, Lange C. Inferring genetic causal effects on survival data with associated endo-phenotypes. Genet Epidemiol. 2011 Feb; 35(2):119-24. PMID: 21254219.
    Citations: 3     Fields:    Translation:Humans
  100. Chang SC, Pauls DL, Lange C, Sasanfar R, Santangelo SL. Common genetic variation in the GAD1 gene and the entire family of DLX homeobox genes and autism spectrum disorders. Am J Med Genet B Neuropsychiatr Genet. 2011 Mar; 156(2):233-9. PMID: 21302352.
    Citations: 8     Fields:    Translation:Humans
  101. Sebro R, Hoffman TJ, Lange C, Rogus JJ, Risch NJ. Testing for non-random mating: evidence for ancestry-related assortative mating in the Framingham heart study. Genet Epidemiol. 2010 Nov; 34(7):674-9. PMID: 20842694.
    Citations: 11     Fields:    Translation:Humans
  102. Wan ES, Cho MH, Boutaoui N, Klanderman BJ, Sylvia JS, Ziniti JP, Won S, Lange C, Pillai SG, Anderson WH, Kong X, Lomas DA, Bakke PS, Gulsvik A, Regan EA, Murphy JR, Make BJ, Crapo JD, Wouters EF, Celli BR, Silverman EK, DeMeo DL. Genome-wide association analysis of body mass in chronic obstructive pulmonary disease. Am J Respir Cell Mol Biol. 2011 Aug; 45(2):304-10. PMID: 21037115.
    Citations: 15     Fields:    Translation:Humans
  103. Murphy A, Chu JH, Xu M, Carey VJ, Lazarus R, Liu A, Szefler SJ, Strunk R, Demuth K, Castro M, Hansel NN, Diette GB, Vonakis BM, Adkinson NF, Klanderman BJ, Senter-Sylvia J, Ziniti J, Lange C, Pastinen T, Raby BA. Mapping of numerous disease-associated expression polymorphisms in primary peripheral blood CD4+ lymphocytes. Hum Mol Genet. 2010 Dec 01; 19(23):4745-57. PMID: 20833654.
    Citations: 61     Fields:    Translation:HumansCells
  104. Naylor MG, Weiss ST, Lange C. A Bayesian approach to genetic association studies with family-based designs. Genet Epidemiol. 2010 Sep; 34(6):569-74. PMID: 20818722.
    Citations: 2     Fields:    Translation:Humans
  105. Murphy A, Won S, Rogers A, Chu JH, Raby BA, Lange C. On the genome-wide analysis of copy number variants in family-based designs: methods for combining family-based and population-based information for testing dichotomous or quantitative traits, or completely ascertained samples. Genet Epidemiol. 2010 Sep; 34(6):582-90. PMID: 20718041.
    Citations: 4     Fields:    Translation:Humans
  106. Himes BE, Lasky-Su J, Wu AC, Wilk JB, Hunninghake GM, Klanderman B, Murphy AJ, Lazarus R, Soto-Quiros ME, Avila L, Celedón JC, Lange C, O'Connor GT, Raby BA, Silverman EK, Weiss ST. Asthma-susceptibility variants identified using probands in case-control and family-based analyses. BMC Med Genet. 2010 Aug 10; 11:122. PMID: 20698975.
    Citations: 5     Fields:    Translation:Humans
  107. Krummel B, Strassburg A, Ernst M, Reiling N, Eker B, Rath H, Hoerster R, Wappler W, Glaewe A, Schoellhorn V, Sotgiu G, Lange C. Potential role for IL-2 ELISpot in differentiating recent and remote infection in tuberculosis contact tracing. PLoS One. 2010 Jul 20; 5(7):e11670. PMID: 20652022.
    Citations: 8     Fields:    Translation:HumansCells
  108. Naylor MG, Lin X, Weiss ST, Raby BA, Lange C. Using canonical correlation analysis to discover genetic regulatory variants. PLoS One. 2010 May 13; 5(5):e10395. PMID: 20485529.
    Citations: 7     Fields:    Translation:Humans
  109. Lasky-Su J, Lange C. Statistical challenges for genome-wide association studies of suicidality using family data. Eur Psychiatry. 2010 Jun; 25(5):307-9. PMID: 20447807.
    Citations: 1     Fields:    Translation:Humans
  110. Lasky-Su J, Won S, Mick E, Anney RJ, Franke B, Neale B, Biederman J, Smalley SL, Loo SK, Todorov A, Faraone SV, Weiss ST, Lange C. On genome-wide association studies for family-based designs: an integrative analysis approach combining ascertained family samples with unselected controls. Am J Hum Genet. 2010 Apr 09; 86(4):573-80. PMID: 20346434.
    Citations: 11     Fields:    Translation:Humans
  111. Cho MH, Boutaoui N, Klanderman BJ, Sylvia JS, Ziniti JP, Hersh CP, DeMeo DL, Hunninghake GM, Litonjua AA, Sparrow D, Lange C, Won S, Murphy JR, Beaty TH, Regan EA, Make BJ, Hokanson JE, Crapo JD, Kong X, Anderson WH, Tal-Singer R, Lomas DA, Bakke P, Gulsvik A, Pillai SG, Silverman EK. Variants in FAM13A are associated with chronic obstructive pulmonary disease. Nat Genet. 2010 Mar; 42(3):200-2. PMID: 20173748.
    Citations: 148     Fields:    Translation:HumansCells
  112. Moerkerke B, Vansteelandt S, Lange C. A doubly robust test for gene-environment interaction in family-based studies of affected offspring. Biostatistics. 2010 Apr; 11(2):213-25. PMID: 20154305.
    Citations: 8     Fields:    Translation:Humans
  113. Wu AC, Himes BE, Lasky-Su J, Litonjua A, Li L, Lange C, Lima J, Irvin CG, Weiss ST. Development of a Pharmacogenetic Predictive Test in asthma: proof of concept. Pharmacogenet Genomics. 2010 Feb; 20(2):86-93. PMID: 20032818.
    Citations: 3     Fields:    Translation:Humans
  114. Lasky-Su J, Murphy A, McQueen MB, Weiss S, Lange C. An omnibus test for family-based association studies with multiple SNPs and multiple phenotypes. Eur J Hum Genet. 2010 Jun; 18(6):720-5. PMID: 20087406.
    Citations: 3     Fields:    Translation:Humans
  115. Rogers AJ, Raby BA, Lima J, Lasky-Su JA, Murphy A, Lazarus R, Klanderman B, Sylvia JS, Ziniti JP, Lange C, Celedón JC, Silverman EK, Weiss ST. Stronger evidence for replication of NPPA using genome-wide genotyping data. Am J Respir Crit Care Med. 2010 Jan 01; 181(1):96. PMID: 20026756.
    Citations:    Fields:    Translation:Humans
  116. Murphy A, T Weiss S, Lange C. Two-stage testing strategies for genome-wide association studies in family-based designs. Methods Mol Biol. 2010; 620:485-96. PMID: 20652517.
    Citations: 2     Fields:    Translation:Humans
  117. Hunninghake GM, Cho MH, Tesfaigzi Y, Soto-Quiros ME, Avila L, Lasky-Su J, Stidley C, Melén E, Söderhäll C, Hallberg J, Kull I, Kere J, Svartengren M, Pershagen G, Wickman M, Lange C, Demeo DL, Hersh CP, Klanderman BJ, Raby BA, Sparrow D, Shapiro SD, Silverman EK, Litonjua AA, Weiss ST, Celedón JC. MMP12, lung function, and COPD in high-risk populations. N Engl J Med. 2009 Dec 31; 361(27):2599-608. PMID: 20018959.
    Citations: 93     Fields:    Translation:HumansCellsCTClinical Trials
  118. Hoffmann TJ, Lange C, Vansteelandt S, Raby BA, DeMeo DL, Silverman EK, Weiss ST, Laird NM. Parsing the effects of individual SNPs in candidate genes with family data. Hum Hered. 2010; 69(2):91-103. PMID: 19996607.
    Citations: 1     Fields:    Translation:Humans
  119. Hoffmann TJ, Lange C, Vansteelandt S, Laird NM. Gene-environment interaction tests for dichotomous traits in trios and sibships. Genet Epidemiol. 2009 Dec; 33(8):691-9. PMID: 19365860.
    Citations: 15     Fields:    Translation:Humans
  120. Won S, Wilk JB, Mathias RA, O'Donnell CJ, Silverman EK, Barnes K, O'Connor GT, Weiss ST, Lange C. On the analysis of genome-wide association studies in family-based designs: a universal, robust analysis approach and an application to four genome-wide association studies. PLoS Genet. 2009 Nov; 5(11):e1000741. PMID: 19956679.
    Citations: 20     Fields:    Translation:Humans
  121. Won S, Bertram L, Becker D, Tanzi RE, Lange C. Maximizing the Power of Genome-Wide Association Studies: A Novel Class of Powerful Family-Based Association Tests. Stat Biosci. 2009 Nov; 1(2):125-143. PMID: 22582089.
    Citations: 3     
  122. Heid IM, Huth C, Loos RJ, Kronenberg F, Adamkova V, Anand SS, Ardlie K, Biebermann H, Bjerregaard P, Boeing H, Bouchard C, Ciullo M, Cooper JA, Corella D, Dina C, Engert JC, Fisher E, Francès F, Froguel P, Hebebrand J, Hegele RA, Hinney A, Hoehe MR, Hu FB, Hubacek JA, Humphries SE, Hunt SC, Illig T, Järvelin MR, Kaakinen M, Kollerits B, Krude H, Kumar J, Lange LA, Langer B, Li S, Luchner A, Lyon HN, Meyre D, Mohlke KL, Mooser V, Nebel A, Nguyen TT, Paulweber B, Perusse L, Qi L, Rankinen T, Rosskopf D, Schreiber S, Sengupta S, Sorice R, Suk A, Thorleifsson G, Thorsteinsdottir U, Völzke H, Vimaleswaran KS, Wareham NJ, Waterworth D, Yusuf S, Lindgren C, McCarthy MI, Lange C, Hirschhorn JN, Laird N, Wichmann HE. Meta-analysis of the INSIG2 association with obesity including 74,345 individuals: does heterogeneity of estimates relate to study design? PLoS Genet. 2009 Oct; 5(10):e1000694. PMID: 19851442.
    Citations: 22     Fields:    Translation:Humans
  123. DeMeo DL, Mariani T, Bhattacharya S, Srisuma S, Lange C, Litonjua A, Bueno R, Pillai SG, Lomas DA, Sparrow D, Shapiro SD, Criner GJ, Kim HP, Chen Z, Choi AM, Reilly J, Silverman EK. Integration of genomic and genetic approaches implicates IREB2 as a COPD susceptibility gene. Am J Hum Genet. 2009 Oct; 85(4):493-502. PMID: 19800047.
    Citations: 54     Fields:    Translation:HumansCells
  124. Kalsdorf B, Scriba TJ, Wood K, Day CL, Dheda K, Dawson R, Hanekom WA, Lange C, Wilkinson RJ. HIV-1 infection impairs the bronchoalveolar T-cell response to mycobacteria. Am J Respir Crit Care Med. 2009 Dec 15; 180(12):1262-70. PMID: 19797156.
    Citations: 50     Fields:    Translation:HumansCells
  125. Fardo DW, Ionita-Laza I, Lange C. On quality control measures in genome-wide association studies: a test to assess the genotyping quality of individual probands in family-based association studies and an application to the HapMap data. PLoS Genet. 2009 Jul; 5(7):e1000572. PMID: 19629167.
    Citations: 3     Fields:    Translation:Humans
  126. Jafari C, Thijsen S, Sotgiu G, Goletti D, Domínguez Benítez JA, Losi M, Eberhardt R, Kirsten D, Kalsdorf B, Bossink A, Latorre I, Migliori GB, Strassburg A, Winteroll S, Greinert U, Richeldi L, Ernst M, Lange C. Bronchoalveolar lavage enzyme-linked immunospot for a rapid diagnosis of tuberculosis: a Tuberculosis Network European Trialsgroup study. Am J Respir Crit Care Med. 2009 Oct 01; 180(7):666-73. PMID: 19590020.
    Citations: 30     Fields:    Translation:HumansCellsCTClinical Trials
  127. Vansteelandt S, Goetgeluk S, Lutz S, Waldman I, Lyon H, Schadt EE, Weiss ST, Lange C. On the adjustment for covariates in genetic association analysis: a novel, simple principle to infer direct causal effects. Genet Epidemiol. 2009 Jul; 33(5):394-405. PMID: 19219893.
    Citations: 16     Fields:    Translation:Humans
  128. Naylor MG, Weiss ST, Lange C. Recommendations for using standardised phenotypes in genetic association studies. Hum Genomics. 2009 Jul; 3(4):308-19. PMID: 19706362.
    Citations: 4     Fields:    Translation:HumansCells
  129. Fardo DW, Becker KD, Bertram L, Tanzi RE, Lange C. Recovering unused information in genome-wide association studies: the benefit of analyzing SNPs out of Hardy-Weinberg equilibrium. Eur J Hum Genet. 2009 Dec; 17(12):1676-82. PMID: 19491930.
    Citations: 12     Fields:    Translation:Humans
  130. Levy H, Murphy A, Zou F, Gerard C, Klanderman B, Schuemann B, Lazarus R, García KC, Celedón JC, Drumm M, Dahmer M, Quasney M, Schneck K, Reske M, Knowles MR, Pier GB, Lange C, Weiss ST. IL1B polymorphisms modulate cystic fibrosis lung disease. Pediatr Pulmonol. 2009 Jun; 44(6):580-93. PMID: 19431193.
    Citations: 14     Fields:    Translation:Humans
  131. Himes BE, Hunninghake GM, Baurley JW, Rafaels NM, Sleiman P, Strachan DP, Wilk JB, Willis-Owen SA, Klanderman B, Lasky-Su J, Lazarus R, Murphy AJ, Soto-Quiros ME, Avila L, Beaty T, Mathias RA, Ruczinski I, Barnes KC, Celedón JC, Cookson WO, Gauderman WJ, Gilliland FD, Hakonarson H, Lange C, Moffatt MF, O'Connor GT, Raby BA, Silverman EK, Weiss ST. Genome-wide association analysis identifies PDE4D as an asthma-susceptibility gene. Am J Hum Genet. 2009 May; 84(5):581-93. PMID: 19426955.
    Citations: 129     Fields:    Translation:Humans
  132. Fox AA, Collard CD, Shernan SK, Seidman CE, Seidman JG, Liu KY, Muehlschlegel JD, Perry TE, Aranki SF, Lange C, Herman DS, Meitinger T, Lichtner P, Body SC. Natriuretic peptide system gene variants are associated with ventricular dysfunction after coronary artery bypass grafting. Anesthesiology. 2009 Apr; 110(4):738-47. PMID: 19326473.
    Citations: 18     Fields:    Translation:Humans
  133. Ionita-Laza I, Lange C, M Laird N. Estimating the number of unseen variants in the human genome. Proc Natl Acad Sci U S A. 2009 Mar 31; 106(13):5008-13. PMID: 19276111.
    Citations: 25     Fields:    Translation:Humans
  134. Rogers AJ, Raby BA, Lasky-Su JA, Murphy A, Lazarus R, Klanderman BJ, Sylvia JS, Ziniti JP, Lange C, Celedón JC, Silverman EK, Weiss ST. Assessing the reproducibility of asthma candidate gene associations, using genome-wide data. Am J Respir Crit Care Med. 2009 Jun 15; 179(12):1084-90. PMID: 19264973.
    Citations: 36     Fields:    Translation:HumansCTClinical Trials
  135. Ding X, Weiss S, Raby B, Lange C, Laird NM. Impact of population stratification on family-based association tests with longitudinal measurements. Stat Appl Genet Mol Biol. 2009; 8:Article 17. PMID: 19222384.
    Citations: 2     Fields:    Translation:Humans
  136. Murphy A, Lasky-Su J, Tantisira KG, Litonjua AA, Lange C, Weiss ST. Genome-wide association studies of family data in pharmacogenetics: a case study. Curr Pharm Des. 2009; 15(32):3764-72. PMID: 19925427.
    Citations: 1     Fields:    Translation:Humans
  137. Neale BM, Lasky-Su J, Anney R, Franke B, Zhou K, Maller JB, Vasquez AA, Asherson P, Chen W, Banaschewski T, Buitelaar J, Ebstein R, Gill M, Miranda A, Oades RD, Roeyers H, Rothenberger A, Sergeant J, Steinhausen HC, Sonuga-Barke E, Mulas F, Taylor E, Laird N, Lange C, Daly M, Faraone SV. Genome-wide association scan of attention deficit hyperactivity disorder. Am J Med Genet B Neuropsychiatr Genet. 2008 Dec 05; 147B(8):1337-44. PMID: 18980221.
    Citations: 91     Fields:    Translation:Humans
  138. Lasky-Su J, Neale BM, Franke B, Anney RJ, Zhou K, Maller JB, Vasquez AA, Chen W, Asherson P, Buitelaar J, Banaschewski T, Ebstein R, Gill M, Miranda A, Mulas F, Oades RD, Roeyers H, Rothenberger A, Sergeant J, Sonuga-Barke E, Steinhausen HC, Taylor E, Daly M, Laird N, Lange C, Faraone SV. Genome-wide association scan of quantitative traits for attention deficit hyperactivity disorder identifies novel associations and confirms candidate gene associations. Am J Med Genet B Neuropsychiatr Genet. 2008 Dec 05; 147B(8):1345-54. PMID: 18821565.
    Citations: 122     Fields:    Translation:Humans
  139. Lasky-Su J, Anney RJ, Neale BM, Franke B, Zhou K, Maller JB, Vasquez AA, Chen W, Asherson P, Buitelaar J, Banaschewski T, Ebstein R, Gill M, Miranda A, Mulas F, Oades RD, Roeyers H, Rothenberger A, Sergeant J, Sonuga-Barke E, Steinhausen HC, Taylor E, Daly M, Laird N, Lange C, Faraone SV. Genome-wide association scan of the time to onset of attention deficit hyperactivity disorder. Am J Med Genet B Neuropsychiatr Genet. 2008 Dec 05; 147B(8):1355-8. PMID: 18937294.
    Citations: 36     Fields:    Translation:Humans
  140. Bertram L, Lange C, Mullin K, Parkinson M, Hsiao M, Hogan MF, Schjeide BM, Hooli B, Divito J, Ionita I, Jiang H, Laird N, Moscarillo T, Ohlsen KL, Elliott K, Wang X, Hu-Lince D, Ryder M, Murphy A, Wagner SL, Blacker D, Becker KD, Tanzi RE. Genome-wide association analysis reveals putative Alzheimer's disease susceptibility loci in addition to APOE. Am J Hum Genet. 2008 Nov; 83(5):623-32. PMID: 18976728.
    Citations: 151     Fields:    Translation:HumansCells
  141. Ionita-Laza I, Rogers AJ, Lange C, Raby BA, Lee C. Genetic association analysis of copy-number variation (CNV) in human disease pathogenesis. Genomics. 2009 Jan; 93(1):22-6. PMID: 18822366.
    Citations: 64     Fields:    Translation:Humans
  142. Goletti D, Carrara S, Stefania C, Butera O, Amicosante M, Ernst M, Sauzullo I, Vullo V, Cirillo D, Borroni E, Markova R, Drenska R, Dominguez J, Latorre I, Angeletti C, Navarra A, Petrosillo N, Lauria FN, Ippolito G, Migliori GB, Lange C, Girardi E. Accuracy of immunodiagnostic tests for active tuberculosis using single and combined results: a multicenter TBNET-Study. PLoS One. 2008; 3(10):e3417. PMID: 18923709.
    Citations: 22     Fields:    Translation:HumansCellsCTClinical Trials
  143. Schjeide BM, McQueen MB, Mullin K, DiVito J, Hogan MF, Parkinson M, Hooli B, Lange C, Blacker D, Tanzi RE, Bertram L. Assessment of Alzheimer's disease case-control associations using family-based methods. Neurogenetics. 2009 Feb; 10(1):19-25. PMID: 18830724.
    Citations: 26     Fields:    Translation:Humans
  144. Murphy A, Weiss ST, Lange C. Screening and replication using the same data set: testing strategies for family-based studies in which all probands are affected. PLoS Genet. 2008 Sep 19; 4(9):e1000197. PMID: 18802462.
    Citations: 16     Fields:    Translation:Humans
  145. Ding X, Lange C, Xu X, Laird N. New powerful approaches for family-based association tests with longitudinal measurements. Ann Hum Genet. 2009 Jan; 73(1):74-83. PMID: 18798838.
    Citations: 5     Fields:    Translation:Humans
  146. Ionita-Laza I, Laird NM, Raby BA, Weiss ST, Lange C. On the frequency of copy number variants. Bioinformatics. 2008 Oct 15; 24(20):2350-5. PMID: 18689430.
    Citations: 3     Fields:    Translation:Humans
  147. Litonjua AA, Lasky-Su J, Schneiter K, Tantisira KG, Lazarus R, Klanderman B, Lima JJ, Irvin CG, Peters SP, Hanrahan JP, Liggett SB, Hawkins GA, Meyers DA, Bleecker ER, Lange C, Weiss ST. ARG1 is a novel bronchodilator response gene: screening and replication in four asthma cohorts. Am J Respir Crit Care Med. 2008 Oct 01; 178(7):688-94. PMID: 18617639.
    Citations: 34     Fields:    Translation:Humans
  148. Degnan JH, Lasky-Su J, Raby BA, Xu M, Molony C, Schadt EE, Lange C. Genomics and genome-wide association studies: an integrative approach to expression QTL mapping. Genomics. 2008 Sep; 92(3):129-33. PMID: 18586451.
    Citations: 8     Fields:    Translation:Humans
  149. Poon AH, Tantisira KG, Litonjua AA, Lazarus R, Xu J, Lasky-Su J, Lima JJ, Irvin CG, Hanrahan JP, Lange C, Weiss ST. Association of corticotropin-releasing hormone receptor-2 genetic variants with acute bronchodilator response in asthma. Pharmacogenet Genomics. 2008 May; 18(5):373-82. PMID: 18408560.
    Citations: 14     Fields:    Translation:Humans
  150. Lasky-Su J, Lyon HN, Emilsson V, Heid IM, Molony C, Raby BA, Lazarus R, Klanderman B, Soto-Quiros ME, Avila L, Silverman EK, Thorleifsson G, Thorsteinsdottir U, Kronenberg F, Vollmert C, Illig T, Fox CS, Levy D, Laird N, Ding X, McQueen MB, Butler J, Ardlie K, Papoutsakis C, Dedoussis G, O'Donnell CJ, Wichmann HE, Celedón JC, Schadt E, Hirschhorn J, Weiss ST, Stefansson K, Lange C. On the replication of genetic associations: timing can be everything! Am J Hum Genet. 2008 Apr; 82(4):849-58. PMID: 18387595.
    Citations: 61     Fields:    Translation:Humans
  151. Ionita-Laza I, Perry GH, Raby BA, Klanderman B, Lee C, Laird NM, Weiss ST, Lange C. On the analysis of copy-number variations in genome-wide association studies: a translation of the family-based association test. Genet Epidemiol. 2008 Apr; 32(3):273-84. PMID: 18228561.
    Citations: 32     Fields:    Translation:Humans
  152. Rakovski CS, Weiss ST, Laird NM, Lange C. FBAT-SNP-PC: an approach for multiple markers and single trait in family-based association tests. Hum Hered. 2008; 66(2):122-6. PMID: 18382091.
    Citations: 1     Fields:    Translation:Humans
  153. Lasky-Su J, Lange C, Biederman J, Tsuang M, Doyle AE, Smoller JW, Laird N, Faraone S. Family-based association analysis of a statistically derived quantitative traits for ADHD reveal an association in DRD4 with inattentive symptoms in ADHD individuals. Am J Med Genet B Neuropsychiatr Genet. 2008 Jan 05; 147B(1):100-6. PMID: 17579349.
    Citations: 12     Fields:    Translation:Humans
  154. Laird NM, Lange C. Family-based methods for linkage and association analysis. Adv Genet. 2008; 60:219-52. PMID: 18358323.
    Citations: 24     Fields:    Translation:Humans
  155. McQueen MB, Bertram L, Lange C, Becker KD, Albert MS, Tanzi RE, Blacker D. Exploring candidate gene associations with neuropsychological performance. Am J Med Genet B Neuropsychiatr Genet. 2007 Dec 05; 144B(8):987-91. PMID: 17579348.
    Citations: 14     Fields:    Translation:Humans
  156. Vansteelandt S, Demeo DL, Lasky-Su J, Smoller JW, Murphy AJ, McQueen M, Schneiter K, Celedon JC, Weiss ST, Silverman EK, Lange C. Testing and estimating gene-environment interactions in family-based association studies. Biometrics. 2008 Jun; 64(2):458-67. PMID: 17970814.
    Citations: 23     Fields:    Translation:Humans
  157. Hersh CP, Raby BA, Soto-Quirós ME, Murphy AJ, Avila L, Lasky-Su J, Sylvia JS, Klanderman BJ, Lange C, Weiss ST, Celedón JC. Comprehensive testing of positionally cloned asthma genes in two populations. Am J Respir Crit Care Med. 2007 Nov 01; 176(9):849-57. PMID: 17702965.
    Citations: 30     Fields:    Translation:Humans
  158. Ionita-Laza I, McQueen MB, Laird NM, Lange C. Genomewide weighted hypothesis testing in family-based association studies, with an application to a 100K scan. Am J Hum Genet. 2007 Sep; 81(3):607-14. PMID: 17701906.
    Citations: 45     Fields:    Translation:Humans
  159. Fardo D, Celedón JC, Raby BA, Weiss ST, Lange C. On dichotomizing phenotypes in family-based association tests: quantitative phenotypes are not always the optimal choice. Genet Epidemiol. 2007 Jul; 31(5):376-82. PMID: 17342772.
    Citations: 3     Fields:    Translation:Humans
  160. Hunninghake GM, Soto-Quirós ME, Avila L, Su J, Murphy A, Demeo DL, Ly NP, Liang C, Sylvia JS, Klanderman BJ, Lange C, Raby BA, Silverman EK, Celedón JC. Polymorphisms in IL13, total IgE, eosinophilia, and asthma exacerbations in childhood. J Allergy Clin Immunol. 2007 Jul; 120(1):84-90. PMID: 17561245.
    Citations: 30     Fields:    Translation:Humans
  161. Lasky-Su J, Biederman J, Laird N, Tsuang M, Doyle AE, Smoller JW, Lange C, Faraone SV. Evidence for an association of the dopamine D5 receptor gene on age at onset of attention deficit hyperactivity disorder. Ann Hum Genet. 2007 Sep; 71(Pt 5):648-59. PMID: 17501935.
    Citations: 6     Fields:    Translation:Humans
  162. Lettre G, Lange C, Hirschhorn JN. Genetic model testing and statistical power in population-based association studies of quantitative traits. Genet Epidemiol. 2007 May; 31(4):358-62. PMID: 17352422.
    Citations: 82     Fields:    Translation:Humans
  163. Lyon HN, Emilsson V, Hinney A, Heid IM, Lasky-Su J, Zhu X, Thorleifsson G, Gunnarsdottir S, Walters GB, Thorsteinsdottir U, Kong A, Gulcher J, Nguyen TT, Scherag A, Pfeufer A, Meitinger T, Brönner G, Rief W, Soto-Quiros ME, Avila L, Klanderman B, Raby BA, Silverman EK, Weiss ST, Laird N, Ding X, Groop L, Tuomi T, Isomaa B, Bengtsson K, Butler JL, Cooper RS, Fox CS, O'Donnell CJ, Vollmert C, Celedón JC, Wichmann HE, Hebebrand J, Stefansson K, Lange C, Hirschhorn JN. The association of a SNP upstream of INSIG2 with body mass index is reproduced in several but not all cohorts. PLoS Genet. 2007 Apr 27; 3(4):e61. PMID: 17465681.
    Citations: 61     Fields:    Translation:Humans
  164. McQueen MB, Weiss S, Laird NM, Lange C. On the parsing of statistical information in family-based association testing. Nat Genet. 2007 Mar; 39(3):281-2. PMID: 17325672.
    Citations: 1     Fields:    Translation:Humans
  165. Hoffmann T, Lange C. P2BAT: a massive parallel implementation of PBAT for genome-wide association studies in R. Bioinformatics. 2006 Dec 15; 22(24):3103-5. PMID: 17021156.
    Citations: 10     Fields:    
  166. DeMeo D, Mariani T, Lange C, Lake S, Litonjua A, Celedón J, Reilly J, Chapman HA, Sparrow D, Spira A, Beane J, Pinto-Plata V, Speizer FE, Shapiro S, Weiss ST, Silverman EK. The SERPINE2 gene is associated with chronic obstructive pulmonary disease. Proc Am Thorac Soc. 2006 Aug; 3(6):502. PMID: 16921128.
    Citations: 7     Fields:    Translation:HumansAnimals
  167. Bertram L, Hsiao M, Lange C, Blacker D, Tanzi RE. Single-nucleotide polymorphism rs498055 on chromosome 10q24 is not associated with Alzheimer disease in two independent family samples. Am J Hum Genet. 2006 Jul; 79(1):180-3; author reply 183-4. PMID: 16773580.
    Citations: 5     Fields:    Translation:HumansCells
  168. Laird NM, Lange C. Family-based designs in the age of large-scale gene-association studies. Nat Rev Genet. 2006 May; 7(5):385-94. PMID: 16619052.
    Citations: 131     Fields:    Translation:Humans
  169. Weiss ST, Litonjua AA, Lange C, Lazarus R, Liggett SB, Bleecker ER, Tantisira KG. Overview of the pharmacogenetics of asthma treatment. Pharmacogenomics J. 2006 Sep-Oct; 6(5):311-26. PMID: 16568148.
    Citations: 20     Fields:    Translation:HumansAnimals
  170. Herbert A, Gerry NP, McQueen MB, Heid IM, Pfeufer A, Illig T, Wichmann HE, Meitinger T, Hunter D, Hu FB, Colditz G, Hinney A, Hebebrand J, Koberwitz K, Zhu X, Cooper R, Ardlie K, Lyon H, Hirschhorn JN, Laird NM, Lenburg ME, Lange C, Christman MF. A common genetic variant is associated with adult and childhood obesity. Science. 2006 Apr 14; 312(5771):279-83. PMID: 16614226.
    Citations: 221     Fields:    Translation:Humans
  171. Blumenthal A, Ehlers S, Lauber J, Buer J, Lange C, Goldmann T, Heine H, Brandt E, Reiling N. The Wingless homolog WNT5A and its receptor Frizzled-5 regulate inflammatory responses of human mononuclear cells induced by microbial stimulation. Blood. 2006 Aug 01; 108(3):965-73. PMID: 16601243.
    Citations: 108     Fields:    Translation:HumansCells
  172. Jiang H, Harrington D, Raby BA, Bertram L, Blacker D, Weiss ST, Lange C. Family-based association test for time-to-onset data with time-dependent differences between the hazard functions. Genet Epidemiol. 2006 Feb; 30(2):124-32. PMID: 16374805.
    Citations: 7     Fields:    Translation:Humans
  173. McQueen MB, Murphy A, Kraft P, Su J, Lazarus R, Laird NM, Lange C, Van Steen K. Comparison of linkage and association strategies for quantitative traits using the COGA dataset. BMC Genet. 2005 Dec 30; 6 Suppl 1:S96. PMID: 16451712.
    Citations:    Fields:    Translation:HumansCells
  174. Murphy A, McQueen MB, Su J, Kraft P, Lazarus R, Laird NM, Lange C, Van Steen K. Genomic screening in family-based association testing. BMC Genet. 2005 Dec 30; 6 Suppl 1:S115. PMID: 16451572.
    Citations: 2     Fields:    Translation:Humans
  175. Demeo DL, Mariani TJ, Lange C, Srisuma S, Litonjua AA, Celedon JC, Lake SL, Reilly JJ, Chapman HA, Mecham BH, Haley KJ, Sylvia JS, Sparrow D, Spira AE, Beane J, Pinto-Plata V, Speizer FE, Shapiro SD, Weiss ST, Silverman EK. The SERPINE2 gene is associated with chronic obstructive pulmonary disease. Am J Hum Genet. 2006 Feb; 78(2):253-64. PMID: 16358219.
    Citations: 66     Fields:    Translation:HumansAnimals
  176. McQueen MB, Devlin B, Faraone SV, Nimgaonkar VL, Sklar P, Smoller JW, Abou Jamra R, Albus M, Bacanu SA, Baron M, Barrett TB, Berrettini W, Blacker D, Byerley W, Cichon S, Coryell W, Craddock N, Daly MJ, Depaulo JR, Edenberg HJ, Foroud T, Gill M, Gilliam TC, Hamshere M, Jones I, Jones L, Juo SH, Kelsoe JR, Lambert D, Lange C, Lerer B, Liu J, Maier W, Mackinnon JD, McInnis MG, McMahon FJ, Murphy DL, Nothen MM, Nurnberger JI, Pato CN, Pato MT, Potash JB, Propping P, Pulver AE, Rice JP, Rietschel M, Scheftner W, Schumacher J, Segurado R, Van Steen K, Xie W, Zandi PP, Laird NM. Combined analysis from eleven linkage studies of bipolar disorder provides strong evidence of susceptibility loci on chromosomes 6q and 8q. Am J Hum Genet. 2005 Oct; 77(4):582-95. PMID: 16175504.
    Citations: 68     Fields:    Translation:HumansCells
  177. Randolph AG, Lange C, Silverman EK, Lazarus R, Weiss ST. Extended haplotype in the tumor necrosis factor gene cluster is associated with asthma and asthma-related phenotypes. Am J Respir Crit Care Med. 2005 Sep 15; 172(6):687-92. PMID: 15976383.
    Citations: 14     Fields:    Translation:Humans
  178. Van Steen K, McQueen MB, Herbert A, Raby B, Lyon H, Demeo DL, Murphy A, Su J, Datta S, Rosenow C, Christman M, Silverman EK, Laird NM, Weiss ST, Lange C. Genomic screening and replication using the same data set in family-based association testing. Nat Genet. 2005 Jul; 37(7):683-91. PMID: 15937480.
    Citations: 85     Fields:    Translation:Humans