Title Professor of Biostatistics Institution Harvard T.H. Chan School of Public Health Address Harvard School of Public Hlth
Dept of Biostatistics
665 Huntington Ave
Boston MA 02115
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Title
Assistant Professor of Medicine
Institution
Brigham and Women's Hospital
Overview
Research
Christoph's research interests are at the intersection of biostatistical methodology, numerical analysis, and computer science. Formally trained in all 3 areas, Christoph headed the analysis of the first genome-wide association study for complex diseases, the longitudinal analysis of BMI in the Framingham Heart Study. To address the challenges of this first wave of "big data" in genetics, Christoph's group developed statistical methodology to maximize power in such studies that minimize the effects of the multiple testing problem in GWAS and developed massively parallel software implementations for the analysis that also efficiently scale with the study size (PBAT software package). Christoph's group then successfully commercialized
the package in collaboration with GoldenHelix.
Currently, Christoph's group focuses on the statistical and computational challenges posed by whole-genome sequencing studies, e.g. powerful analysis methodology, clustering approaches of the genome, approaches to permutation testing, storage algorithm, etc.
Christoph is also involved in collaborative research in Asthma Genetics, COPD Genetics, and Alzheimer's Genetics.
Education
Ph.D., 2000, University of Reading, United Kingdom
Research
The research activities and funding listed below are automatically derived from
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R01HG008976
(LANGE, CHRISTOPH)
Sep 27, 2016 - Jun 30, 2020
Preparing Association Analysis Software Tools for Next Generation Sequencing Data
Role: Principal Investigator
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P01HL132825
(WEISS, SCOTT T)
Sep 1, 2016 - Jul 31, 2021
Systems Biology of Airway Disease
Role: Co-Principal Investigator
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R01MH087590
(LANGE, CHRISTOPH)
Dec 1, 2009 - Nov 30, 2014
A New Approach to Mental Health Phenotypes in Family Genomewide Association
Role: Principal Investigator
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R01MH081862
(LANGE, CHRISTOPH)
Dec 1, 2007 - Mar 31, 2016
Novel Statistical Approaches to Mental Health Phenotype Analysis in GWA Studies
Role: Principal Investigator
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P01HL083069
(WEISS, SCOTT T)
Mar 23, 2007 - Jan 31, 2014
Common Genetic Determinants of Asthma and COPD-PROGRAM PROJECT
Role: Co-Principal Investigator
Bibliographic
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