Harvard Catalyst Profiles

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Christoph Lange, Ph.D.

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Christoph's research interests are at the intersection of biostatistical methodology, numerical analysis, and computer science. Formally trained in all 3 areas, Christoph headed the analysis of the first genome-wide association study for complex diseases, the longitudinal analysis of BMI in the Framingham Heart Study. To address the challenges of this first wave of "big data" in genetics, Christoph's group developed statistical methodology to maximize power in such studies that minimize the effects of the multiple testing problem in GWAS and developed massively parallel software implementations for the analysis that also efficiently scale with the study size (PBAT software package). Christoph's group then successfully commercialized
the package in collaboration with GoldenHelix.

Currently, Christoph's group focuses on the statistical and computational challenges posed by whole-genome sequencing studies, e.g. powerful analysis methodology, clustering approaches of the genome, approaches to permutation testing, storage algorithm, etc.

Christoph is also involved in collaborative research in Asthma Genetics, COPD Genetics, and Alzheimer's Genetics.


Ph.D., 2000, University of Reading, United Kingdom

The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01HG008976 (LANGE, CHRISTOPH) Sep 27, 2016 - Jun 30, 2020
    Preparing Association Analysis Software Tools for Next Generation Sequencing Data
    Role: Principal Investigator
  2. P01HL132825 (WEISS, SCOTT T) Sep 1, 2016 - Jul 31, 2021
    Systems Biology of Airway Disease
    Role: Co-Principal Investigator
  3. R01MH087590 (LANGE, CHRISTOPH) Dec 1, 2009 - Nov 30, 2014
    A New Approach to Mental Health Phenotypes in Family Genomewide Association
    Role: Principal Investigator
  4. R01MH081862 (LANGE, CHRISTOPH) Dec 1, 2007 - Mar 31, 2016
    Novel Statistical Approaches to Mental Health Phenotype Analysis in GWA Studies
    Role: Principal Investigator
  5. P01HL083069 (WEISS, SCOTT T) Mar 23, 2007 - Jan 31, 2014
    Common Genetic Determinants of Asthma and COPD-PROGRAM PROJECT
    Role: Co-Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Hahn G, Wu CM, Lee S, Lutz SM, Khurana S, Baden LR, Haneuse S, Qiao D, Hecker J, DeMeo DL, Tanzi RE, Choudhary MC, Etemad B, Mohammadi A, Esmaeilzadeh E, Cho MH, Li JZ, Randolph AG, Laird NM, Weiss ST, Silverman EK, Ribbeck K, Lange C. Genome-wide association analysis of COVID-19 mortality risk in SARS-CoV-2 genomes identifies mutation in the SARS-CoV-2 spike protein that colocalizes with P.1 of the Brazilian strain. Genet Epidemiol. 2021 10; 45(7):685-693. PMID: 34159627.
    Citations:    Fields:    Translation:Humans
  2. Lutz SM, Wu AC, Hokanson JE, Vansteelandt S, Lange C. Caution against examining the role of reverse causality in Mendelian Randomization. Genet Epidemiol. 2021 Jul; 45(5):445-454. PMID: 34008876.
    Citations: 1     Fields:    
  3. Lee S, Lasky-Su J, Won S, Laurie C, Celedón JC, Lange C, Weiss S, Hecker J. Novel recessive locus for body mass index in childhood asthma. Thorax. 2021 Apr 22. PMID: 33888571.
    Citations:    Fields:    
  4. Lee S, Lasky-Su JA, Lange C, Kim W, Kumar PL, McDonald MN, Vaz Fragoso CA, Laurie C, Raby BA, Celedón JC, Cho MH, Won S, Weiss ST, Hecker J. A novel locus for exertional dyspnoea in childhood asthma. Eur Respir J. 2021 02; 57(2). PMID: 32855217.
    Citations: 1     Fields:    Translation:Humans
  5. Hahn G, Lee S, Weiss ST, Lange C. Unsupervised cluster analysis of SARS-CoV-2 genomes reflects its geographic progression and identifies distinct genetic subgroups of SARS-CoV-2 virus. Genet Epidemiol. 2021 04; 45(3):316-323. PMID: 33415739.
    Citations: 1     Fields:    Translation:HumansPHPublic Health
  6. Hecker J, William Townes F, Kachroo P, Laurie C, Lasky-Su J, Ziniti J, Cho MH, Weiss ST, Laird NM, Lange C. A unifying framework for rare variant association testing in family-based designs, including higher criticism approaches, SKATs, and burden tests. Bioinformatics. 2020 Dec 26. PMID: 33367522.
    Citations: 1     Fields:    
  7. Hahn G, Lee S, Weiss ST, Lange C. Unsupervised cluster analysis of SARS-CoV-2 genomes reflects its geographic progression and identifies distinct genetic subgroups of SARS-CoV-2 virus. bioRxiv. 2020 Nov 20. PMID: 32637949.
  8. Lee S, Lasky-Su J, Kim W, Won S, Laurie C, Celedón JC, Lange C, Weiss ST, Hecker J. An interaction of the 17q12-21 locus with mold exposure in childhood asthma. Pediatr Allergy Immunol. 2021 02; 32(2):373-376. PMID: 32946604.
    Citations:    Fields:    Translation:HumansAnimalsPHPublic Health
  9. Hahn G, Lutz SM, Hecker J, Prokopenko D, Cho MH, Silverman EK, Weiss ST, Lange C. locStra: Fast analysis of regional/global stratification in whole-genome sequencing studies. Genet Epidemiol. 2021 02; 45(1):82-98. PMID: 32929743.
    Citations: 2     Fields:    Translation:Humans
  10. Hahn G, Cho MH, Weiss ST, Silverman EK, Lange C. Unsupervised cluster analysis of SARS-CoV-2 genomes indicates that recent (June 2020) cases in Beijing are from a genetic subgroup that consists of mostly European and South(east) Asian samples, of which the latter are the most recent. bioRxiv. 2020 Jun 30. PMID: 32637951.
    Citations: 1     
  11. Prokopenko D, Hecker J, Kirchner R, Chapman BA, Hoffman O, Mullin K, Hide W, Bertram L, Laird N, DeMeo DL, Lange C, Tanzi RE. Identification of Novel Alzheimer's Disease Loci Using Sex-Specific Family-Based Association Analysis of Whole-Genome Sequence Data. Sci Rep. 2020 03 19; 10(1):5029. PMID: 32193444.
    Citations: 10     Fields:    Translation:HumansCells
  12. Lutz SM, Sordillo JE, Hokanson JE, Chen Wu A, Lange C. The effects of misspecification of the mediator and outcome in mediation analysis. Genet Epidemiol. 2020 06; 44(4):400-403. PMID: 32166765.
    Citations: 2     Fields:    
  13. Hecker J, Ruczinski I, Cho MH, Silverman EK, Coull B, Lange C. A flexible and nearly optimal sequential testing approach to randomized testing: QUICK-STOP. Genet Epidemiol. 2020 03; 44(2):139-147. PMID: 31713269.
    Citations: 1     Fields:    Translation:Humans
  14. Kachroo P, Hecker J, Chawes BL, Ahluwalia TS, Cho MH, Qiao D, Kelly RS, Chu SH, Virkud YV, Huang M, Barnes KC, Burchard EG, Eng C, Hu D, Celedón JC, Daya M, Levin AM, Gui H, Williams LK, Forno E, Mak ACY, Avila L, Soto-Quiros ME, Cloutier MM, Acosta-Pérez E, Canino G, Bønnelykke K, Bisgaard H, Raby BA, Lange C, Weiss ST, Lasky-Su JA. Whole Genome Sequencing Identifies CRISPLD2 as a Lung Function Gene in Children With Asthma. Chest. 2019 12; 156(6):1068-1079. PMID: 31557467.
    Citations: 3     Fields:    Translation:Humans
  15. Ragland MF, Benway CJ, Lutz SM, Bowler RP, Hecker J, Hokanson JE, Crapo JD, Castaldi PJ, DeMeo DL, Hersh CP, Hobbs BD, Lange C, Beaty TH, Cho MH, Silverman EK. Genetic Advances in Chronic Obstructive Pulmonary Disease. Insights from COPDGene. Am J Respir Crit Care Med. 2019 09 15; 200(6):677-690. PMID: 30908940.
    Citations: 15     Fields:    Translation:Humans
  16. Tortoli E, Brown-Elliott BA, Chalmers JD, Cirillo DM, Daley CL, Emler S, Floto RA, Garcia MJ, Hoefsloot W, Koh WJ, Lange C, Loebinger M, Maurer FP, Morimoto K, Niemann S, Richter E, Turenne CY, Vasireddy R, Vasireddy S, Wagner D, Wallace RJ, Wengenack N, van Ingen J. Same meat, different gravy: ignore the new names of mycobacteria. Eur Respir J. 2019 Jul; 54(1). PMID: 31296783.
    Citations: 6     Fields:    Translation:HumansCells
  17. Wang L, Lee S, Qiao D, Cho MH, Silverman EK, Lange C, Won S. metaFARVAT: An Efficient Tool for Meta-Analysis of Family-Based, Case-Control, and Population-Based Rare Variant Association Studies. Front Genet. 2019; 10:572. PMID: 31275357.
  18. Hecker J, Laird N, Lange C. A comparison of popular TDT-generalizations for family-based association analysis. Genet Epidemiol. 2019 04; 43(3):300-317. PMID: 30609057.
    Citations: 1     Fields:    Translation:Humans
  19. van Leth F, Brinkmann F, Cirillo DM, Dheda K, Duarte R, Guglielmetti L, Kuksa L, Lange C, Mitnick C, Skrahina A, Zaman K, Bothamley G. The Tuberculosis Network European Trials group (TBnet) ERS Clinical Research Collaboration: addressing drug-resistant tuberculosis through European cooperation. Eur Respir J. 2019 01; 53(1). PMID: 30606765.
    Citations:    Fields:    Translation:Humans
  20. Lange C, Chesov D, Heyckendorf J. Clofazimine for the treatment of multidrug-resistant tuberculosis. Clin Microbiol Infect. 2019 02; 25(2):128-130. PMID: 30472423.
    Citations: 3     Fields:    Translation:Humans
  21. Lange C, Chesov D, Furin J, Udwadia Z, Dheda K. Revising the definition of extensively drug-resistant tuberculosis. Lancet Respir Med. 2018 12; 6(12):893-895. PMID: 30420247.
    Citations: 1     Fields:    Translation:Humans
  22. Prokopenko D, Sakornsakolpat P, Fier HL, Qiao D, Parker MM, McDonald MN, Manichaikul A, Rich SS, Barr RG, Williams CJ, Brantly ML, Lange C, Beaty TH, Crapo JD, Silverman EK, Cho MH. Whole-Genome Sequencing in Severe Chronic Obstructive Pulmonary Disease. Am J Respir Cell Mol Biol. 2018 11; 59(5):614-622. PMID: 29949718.
    Citations: 9     Fields:    Translation:Humans
  23. Qiao D, Ameli A, Prokopenko D, Chen H, Kho AT, Parker MM, Morrow J, Hobbs BD, Liu Y, Beaty TH, Crapo JD, Barnes KC, Nickerson DA, Bamshad M, Hersh CP, Lomas DA, Agusti A, Make BJ, Calverley PMA, Donner CF, Wouters EF, Vestbo J, Paré PD, Levy RD, Rennard SI, Tal-Singer R, Spitz MR, Sharma A, Ruczinski I, Lange C, Silverman EK, Cho MH. Whole exome sequencing analysis in severe chronic obstructive pulmonary disease. Hum Mol Genet. 2018 11 01; 27(21):3801-3812. PMID: 30060175.
    Citations: 10     Fields:    Translation:Humans
  24. Ahmad N, Ahuja SD, Akkerman OW, Alffenaar JC, Anderson LF, Baghaei P, Bang D, Barry PM, Bastos ML, Behera D, Benedetti A, Bisson GP, Boeree MJ, Bonnet M, Brode SK, Brust JCM, Cai Y, Caumes E, Cegielski JP, Centis R, Chan PC, Chan ED, Chang KC, Charles M, Cirule A, Dalcolmo MP, D'Ambrosio L, de Vries G, Dheda K, Esmail A, Flood J, Fox GJ, Fréchet-Jachym M, Fregona G, Gayoso R, Gegia M, Gler MT, Gu S, Guglielmetti L, Holtz TH, Hughes J, Isaakidis P, Jarlsberg L, Kempker RR, Keshavjee S, Khan FA, Kipiani M, Koenig SP, Koh WJ, Kritski A, Kuksa L, Kvasnovsky CL, Kwak N, Lan Z, Lange C, Laniado-Laborín R, Lee M, Leimane V, Leung CC, Leung EC, Li PZ, Lowenthal P, Maciel EL, Marks SM, Mase S, Mbuagbaw L, Migliori GB, Milanov V, Miller AC, Mitnick CD, Modongo C, Mohr E, Monedero I, Nahid P, Ndjeka N, O'Donnell MR, Padayatchi N, Palmero D, Pape JW, Podewils LJ, Reynolds I, Riekstina V, Robert J, Rodriguez M, Seaworth B, Seung KJ, Schnippel K, Shim TS, Singla R, Smith SE, Sotgiu G, Sukhbaatar G, Tabarsi P, Tiberi S, Trajman A, Trieu L, Udwadia ZF, van der Werf TS, Veziris N, Viiklepp P, Vilbrun SC, Walsh K, Westenhouse J, Yew WW, Yim JJ, Zetola NM, Zignol M, Menzies D. Treatment correlates of successful outcomes in pulmonary multidrug-resistant tuberculosis: an individual patient data meta-analysis. Lancet. 2018 09 08; 392(10150):821-834. PMID: 30215381.
    Citations: 98     Fields:    Translation:Humans
  25. Lange C, Sommerfeld M, Namsolleck P, Kintscher U, Unger T, Kaschina E. AT2R (Angiotensin AT2 Receptor) Agonist, Compound 21, Prevents Abdominal Aortic Aneurysm Progression in the Rat. Hypertension. 2018 09; 72(3):e20-e29. PMID: 29987108.
    Citations: 6     Fields:    Translation:Animals
  26. Günther G, van Leth F, Alexandru S, Altet N, Avsar K, Bang D, Barbuta R, Bothamley G, Ciobanu A, Crudu V, Danilovits M, Dedicoat M, Duarte R, Gualano G, Kunst H, de Lange W, Leimane V, McLaughlin AM, Magis-Escurra C, Muylle I, Polcová V, Popa C, Rumetshofer R, Skrahina A, Solodovnikova V, Spinu V, Tiberi S, Viiklepp P, Lange C. Clinical Management of Multidrug-Resistant Tuberculosis in 16 European Countries. Am J Respir Crit Care Med. 2018 08 01; 198(3):379-386. PMID: 29509468.
    Citations: 1     Fields:    Translation:Humans
  27. Salzer HJF, Stoney RJ, Angelo KM, Rolling T, Grobusch MP, Libman M, López-Vélez R, Duvignaud A, Ásgeirsson H, Crespillo-Andújar C, Schwartz E, Gautret P, Bottieau E, Jordan S, Lange C, Hamer DH. Epidemiological aspects of travel-related systemic endemic mycoses: a GeoSentinel analysis, 1997-2017. J Travel Med. 2018 08 01; 25(1). PMID: 30085265.
    Citations: 4     Fields:    Translation:Humans
  28. Salzer HJF, Kuempers C, Pasternack H, Heyckendorf J, Bialek R, Palade E, Hundack L, Kalsdorf B, Lange C. An Unexpected Endobronchial Mass Appearing During Bronchoscopy. Chest. 2018 07; 154(1):e13-e21. PMID: 30044749.
    Citations:    Fields:    Translation:HumansAnimals
  29. Hecker J, Prokopenko D, Lange C, Fier HL. PolyGEE: a generalized estimating equation approach to the efficient and robust estimation of polygenic effects in large-scale association studies. Biostatistics. 2018 07 01; 19(3):295-306. PMID: 28968646.
    Citations: 1     Fields:    Translation:Humans
  30. Lange C, van Leth F, Mitnick CD, Dheda K, Günther G. Time to revise WHO-recommended definitions of MDR-TB treatment outcomes. Lancet Respir Med. 2018 04; 6(4):246-248. PMID: 29595505.
    Citations: 1     Fields:    Translation:Humans
  31. Dheda K, Gumbo T, Lange C, Horsburgh CR, Furin J. Pan-tuberculosis regimens: an argument against. Lancet Respir Med. 2018 04; 6(4):240-242. PMID: 29595502.
    Citations: 3     Fields:    Translation:HumansCells
  32. van Ingen J, Aksamit T, Andrejak C, Böttger EC, Cambau E, Daley CL, Griffith DE, Guglielmetti L, Holland SM, Huitt GA, Koh WJ, Lange C, Leitman P, Marras TK, Morimoto K, Olivier KN, Santin M, Stout JE, Thomson R, Tortoli E, Wallace RJ, Winthrop KL, Wagner D. Treatment outcome definitions in nontuberculous mycobacterial pulmonary disease: an NTM-NET consensus statement. Eur Respir J. 2018 03; 51(3). PMID: 29567726.
    Citations: 31     Fields:    Translation:HumansCells
  33. Hecker J, Xu X, Townes FW, Loehlein Fier H, Corcoran C, Laird N, Lange C. Family-based tests for associating haplotypes with general phenotype data: Improving the FBAT-haplotype algorithm. Genet Epidemiol. 2018 02; 42(1):123-126. PMID: 29159827.
    Citations: 2     Fields:    Translation:Humans
  34. Schlauch D, Fier H, Lange C. Identification of genetic outliers due to sub-structure and cryptic relationships. Bioinformatics. 2017 Jul 01; 33(13):1972-1979. PMID: 28334167.
    Citations: 4     Fields:    Translation:Humans
  35. Hecker J, Maaser A, Prokopenko D, Fier HL, Lange C. Reporting Correct p Values in VEGAS Analyses. Twin Res Hum Genet. 2017 06; 20(3):257-259. PMID: 28345502.
    Citations: 2     Fields:    Translation:Humans
  36. Loehlein Fier H, Prokopenko D, Hecker J, Cho MH, Silverman EK, Weiss ST, Tanzi RE, Lange C. On the association analysis of genome-sequencing data: A spatial clustering approach for partitioning the entire genome into nonoverlapping windows. Genet Epidemiol. 2017 05; 41(4):332-340. PMID: 28318110.
    Citations: 5     Fields:    Translation:Humans
  37. Dheda K, Gumbo T, Maartens G, Dooley KE, McNerney R, Murray M, Furin J, Nardell EA, London L, Lessem E, Theron G, van Helden P, Niemann S, Merker M, Dowdy D, Van Rie A, Siu GK, Pasipanodya JG, Rodrigues C, Clark TG, Sirgel FA, Esmail A, Lin HH, Atre SR, Schaaf HS, Chang KC, Lange C, Nahid P, Udwadia ZF, Horsburgh CR, Churchyard GJ, Menzies D, Hesseling AC, Nuermberger E, McIlleron H, Fennelly KP, Goemaere E, Jaramillo E, Low M, Jara CM, Padayatchi N, Warren RM. The epidemiology, pathogenesis, transmission, diagnosis, and management of multidrug-resistant, extensively drug-resistant, and incurable tuberculosis. Lancet Respir Med. 2017 Mar 15. PMID: 28344011.
    Citations: 133     Fields:    
  38. Qiao D, Lange C, Laird NM, Won S, Hersh CP, Morrow J, Hobbs BD, Lutz SM, Ruczinski I, Beaty TH, Silverman EK, Cho MH. Gene-based segregation method for identifying rare variants in family-based sequencing studies. Genet Epidemiol. 2017 05; 41(4):309-319. PMID: 28191685.
    Citations: 6     Fields:    Translation:Humans
  39. McDonald MN, Won S, Mattheisen M, Castaldi PJ, Cho MH, Rutten E, Hardin M, Yip WK, Rennard SI, Lomas DA, Wouters EFM, Agusti A, Casaburi R, Lange CP, O'Connor G, Hersh CP, Silverman EK. Body mass index change in gastrointestinal cancer and chronic obstructive pulmonary disease is associated with Dedicator of Cytokinesis 1. J Cachexia Sarcopenia Muscle. 2017 Jun; 8(3):428-436. PMID: 28044437.
    Citations: 6     Fields:    Translation:Humans
  40. Lutz SM, Fingerlin TE, Hokanson JE, Lange C. A general approach to testing for pleiotropy with rare and common variants. Genet Epidemiol. 2017 Feb; 41(2):163-170. PMID: 27900789.
    Citations: 7     Fields:    Translation:Humans
  41. Busch M, Herzmann C, Kallert S, Zimmermann A, Höfer C, Mayer D, Zenk SF, Muche R, Lange C, Bloom BR, Modlin RL, Stenger S. Lipoarabinomannan-Responsive Polycytotoxic T Cells Are Associated with Protection in Human Tuberculosis. Am J Respir Crit Care Med. 2016 08 01; 194(3):345-55. PMID: 26882070.
    Citations: 18     Fields:    Translation:HumansCells
  42. Olaru ID, Lange C, Indra A, Meidlinger L, Huhulescu S, Rumetshofer R. High Rates of Treatment Success in Pulmonary Multidrug-Resistant Tuberculosis by Individually Tailored Treatment Regimens. Ann Am Thorac Soc. 2016 08; 13(8):1271-8. PMID: 27163360.
    Citations: 4     Fields:    Translation:Humans
  43. Qiao D, Lange C, Beaty TH, Crapo JD, Barnes KC, Bamshad M, Hersh CP, Morrow J, Pinto-Plata VM, Marchetti N, Bueno R, Celli BR, Criner GJ, Silverman EK, Cho MH. Exome Sequencing Analysis in Severe, Early-Onset Chronic Obstructive Pulmonary Disease. Am J Respir Crit Care Med. 2016 06 15; 193(12):1353-63. PMID: 26736064.
    Citations: 20     Fields:    Translation:Humans
  44. Mitnick CD, Rodriguez CA, Hatton ML, Brigden G, Cobelens F, Grobusch MP, Horsburgh R, Lange C, Lienhardt C, Oren E, Podewils LJ, Seaworth B, van den Hof S, Daley CL, Gebhard AC, Wares F. Programmatic Management of Drug-Resistant Tuberculosis: An Updated Research Agenda. PLoS One. 2016; 11(5):e0155968. PMID: 27223622.
    Citations: 6     Fields:    Translation:Humans
  45. Lange C, van Leth F, Sester M. Viral Load and Risk of Tuberculosis in HIV Infection. . 2016 Feb 01; 71(2):e51-3. PMID: 26761521.
    Citations: 2     Translation:HumansCells
  46. Lange C, Mandalakas AM, Kalsdorf B, Denkinger CM, Sester M. Clinical Application of Interferon-? Release Assays for the Prevention of Tuberculosis in Countries with Low Incidence. Pathog Immun. 2016; 1(2):308-329. PMID: 28217762.
    Citations: 5     
  47. Prokopenko D, Hecker J, Silverman EK, Pagano M, Nöthen MM, Dina C, Lange C, Fier HL. Utilizing the Jaccard index to reveal population stratification in sequencing data: a simulation study and an application to the 1000 Genomes Project. Bioinformatics. 2016 05 01; 32(9):1366-72. PMID: 26722118.
    Citations: 12     Fields:    Translation:HumansAnimals
  48. Hecker J, Prokopenko D, Lange C, Fier HL. On the Recombination Rate Estimation in the Presence of Population Substructure. PLoS One. 2015; 10(12):e0145152. PMID: 26716445.
    Citations:    Fields:    Translation:Humans
  49. Lutz SM, Cho MH, Young K, Hersh CP, Castaldi PJ, McDonald ML, Regan E, Mattheisen M, DeMeo DL, Parker M, Foreman M, Make BJ, Jensen RL, Casaburi R, Lomas DA, Bhatt SP, Bakke P, Gulsvik A, Crapo JD, Beaty TH, Laird NM, Lange C, Hokanson JE, Silverman EK. A genome-wide association study identifies risk loci for spirometric measures among smokers of European and African ancestry. BMC Genet. 2015 Dec 03; 16:138. PMID: 26634245.
    Citations: 54     Fields:    Translation:HumansCellsCTClinical Trials
  50. Park S, Lee S, Lee Y, Herold C, Hooli B, Mullin K, Park T, Park C, Bertram L, Lange C, Tanzi R, Won S. Adjusting heterogeneous ascertainment bias for genetic association analysis with extended families. BMC Med Genet. 2015 Aug 19; 16:62. PMID: 26286599.
    Citations: 3     Fields:    Translation:Humans
  51. Prokopenko D, Hecker J, Silverman E, Nöthen MM, Schmid M, Lange C, Loehlein Fier H. Using Network Methodology to Infer Population Substructure. PLoS One. 2015; 10(6):e0130708. PMID: 26098940.
    Citations:    Fields:    Translation:Humans
  52. Zhou JJ, Cho MH, Lange C, Lutz S, Silverman EK, Laird NM. Integrating Multiple Correlated Phenotypes for Genetic Association Analysis by Maximizing Heritability. Hum Hered. 2015; 79(2):93-104. PMID: 26111731.
    Citations: 9     Fields:    Translation:Humans
  53. Basmanav FB, Forstner AJ, Fier H, Herms S, Meier S, Degenhardt F, Hoffmann P, Barth S, Fricker N, Strohmaier J, Witt SH, Ludwig M, Schmael C, Moebus S, Maier W, Mössner R, Rujescu D, Rietschel M, Lange C, Nöthen MM, Cichon S. Investigation of the role of TCF4 rare sequence variants in schizophrenia. . 2015 Jul; 168B(5):354-62. PMID: 26010163.
    Citations: 6     Translation:Humans
  54. Zellweger JP, Sotgiu G, Block M, Dore S, Altet N, Blunschi R, Bogyi M, Bothamley G, Bothe C, Codecasa L, Costa P, Dominguez J, Duarte R, Fløe A, Fresard I, García-García JM, Goletti D, Halm P, Hellwig D, Henninger E, Heykes-Uden H, Horn L, Kruczak K, Latorre I, Pache G, Rath H, Ringshausen FC, Ruiz AS, Solovic I, Souza-Galvão ML, Widmer U, Witte P, Lange C. Risk Assessment of Tuberculosis in Contacts by IFN-? Release Assays. A Tuberculosis Network European Trials Group Study. Am J Respir Crit Care Med. 2015 May 15; 191(10):1176-84. PMID: 25763458.
    Citations: 31     Fields:    Translation:HumansCellsPHPublic Health
  55. Hooli BV, Lill CM, Mullin K, Qiao D, Lange C, Bertram L, Tanzi RE. PLD3 gene variants and Alzheimer's disease. Nature. 2015 Apr 02; 520(7545):E7-8. PMID: 25832413.
    Citations: 20     Fields:    Translation:Humans
  56. Sester M, van Leth F, Bruchfeld J, Bumbacea D, Cirillo DM, Dilektasli AG, Domínguez J, Duarte R, Ernst M, Eyuboglu FO, Gerogianni I, Girardi E, Goletti D, Janssens JP, Julander I, Lange B, Latorre I, Losi M, Markova R, Matteelli A, Milburn H, Ravn P, Scholman T, Soccal PM, Straub M, Wagner D, Wolf T, Yalcin A, Lange C. Risk assessment of tuberculosis in immunocompromised patients. A TBNET study. Am J Respir Crit Care Med. 2014 Nov 15; 190(10):1168-76. PMID: 25303140.
    Citations: 59     Fields:    Translation:Humans
  57. Günther G, Gomez GB, Lange C, Rupert S, van Leth F. Availability, price and affordability of anti-tuberculosis drugs in Europe: a TBNET survey. Eur Respir J. 2015 Apr; 45(4):1081-8. PMID: 25395035.
    Citations: 12     Fields:    Translation:Humans
  58. Gutsfeld C, Olaru ID, Vollrath O, Lange C. Attitudes about tuberculosis prevention in the elimination phase: a survey among physicians in Germany. PLoS One. 2014; 9(11):e112681. PMID: 25393241.
    Citations: 5     Fields:    Translation:HumansCellsPHPublic Health
  59. McDonald ML, Cho MH, Sørheim IC, Lutz SM, Castaldi PJ, Lomas DA, Coxson HO, Edwards LD, MacNee W, Vestbo J, Yates JC, Agusti A, Calverley PM, Celli B, Crim C, Rennard SI, Wouters EF, Bakke P, Tal-Singer R, Miller BE, Gulsvik A, Casaburi R, Wells JM, Regan EA, Make BJ, Hokanson JE, Lange C, Crapo JD, Beaty TH, Silverman EK, Hersh CP. Common genetic variants associated with resting oxygenation in chronic obstructive pulmonary disease. Am J Respir Cell Mol Biol. 2014 Nov; 51(5):678-87. PMID: 24825563.
    Citations: 11     Fields:    Translation:HumansCellsCTClinical Trials
  60. Castaldi PJ, Cho MH, Zhou X, Qiu W, Mcgeachie M, Celli B, Bakke P, Gulsvik A, Lomas DA, Crapo JD, Beaty TH, Rennard S, Harshfield B, Lange C, Singh D, Tal-Singer R, Riley JH, Quackenbush J, Raby BA, Carey VJ, Silverman EK, Hersh CP. Genetic control of gene expression at novel and established chronic obstructive pulmonary disease loci. Hum Mol Genet. 2015 Feb 15; 24(4):1200-10. PMID: 25315895.
    Citations: 21     Fields:    Translation:HumansCells
  61. Yip WK, Fier H, DeMeo DL, Aryee M, Laird N, Lange C. A novel method for detecting association between DNA methylation and diseases using spatial information. Genet Epidemiol. 2014 Dec; 38(8):714-21. PMID: 25250875.
    Citations: 2     Fields:    Translation:HumansCells
  62. Hooli BV, Parrado AR, Mullin K, Yip WK, Liu T, Roehr JT, Qiao D, Jessen F, Peters O, Becker T, Ramirez A, Lange C, Bertram L, Tanzi RE. The rare TREM2 R47H variant exerts only a modest effect on Alzheimer disease risk. Neurology. 2014 Oct 07; 83(15):1353-8. PMID: 25186855.
    Citations: 17     Fields:    Translation:Humans
  63. Blauenfeldt T, Heyckendorf J, Graff Jensen S, Lange C, Drabe C, Hermansen TS, de Thurah L, Lillebaek T, Eugen-Olsen J, Seersholm N, Hoff S, Bonde J, Ruhwald M. Development of a one-step probe based molecular assay for rapid immunodiagnosis of infection with M. tuberculosis using dried blood spots. PLoS One. 2014; 9(9):e105628. PMID: 25184553.
    Citations: 4     Fields:    Translation:HumansCells
  64. McDonald ML, Mattheisen M, Cho MH, Liu YY, Harshfield B, Hersh CP, Bakke P, Gulsvik A, Lange C, Beaty TH, Silverman EK. Beyond GWAS in COPD: probing the landscape between gene-set associations, genome-wide associations and protein-protein interaction networks. Hum Hered. 2014; 78(3-4):131-9. PMID: 25171373.
    Citations: 10     Fields:    Translation:Humans
  65. Essone PN, Kalsdorf B, Chegou NN, Loxton AG, Kriel M, Preyer R, Ernst M, Walzl G, Lange C. Bifunctional T-cell-derived cytokines for the diagnosis of tuberculosis and treatment monitoring. Respiration. 2014; 88(3):251-61. PMID: 25171202.
    Citations: 6     Fields:    Translation:HumansCells
  66. Choi S, Lee S, Cichon S, Nöthen MM, Lange C, Park T, Won S. FARVAT: a family-based rare variant association test. Bioinformatics. 2014 Nov 15; 30(22):3197-205. PMID: 25075118.
    Citations: 15     Fields:    Translation:Humans
  67. Lutz SM, Hokanson JE, Lange C. An alternative hypothesis testing strategy for secondary phenotype data in case-control genetic association studies. Front Genet. 2014; 5:188. PMID: 25071819.
    Citations: 7     
  68. Juraeva D, Haenisch B, Zapatka M, Frank J, Witt SH, Mühleisen TW, Treutlein J, Strohmaier J, Meier S, Degenhardt F, Giegling I, Ripke S, Leber M, Lange C, Schulze TG, Mössner R, Nenadic I, Sauer H, Rujescu D, Maier W, Børglum A, Ophoff R, Cichon S, Nöthen MM, Rietschel M, Mattheisen M, Brors B. Integrated pathway-based approach identifies association between genomic regions at CTCF and CACNB2 and schizophrenia. PLoS Genet. 2014 Jun; 10(6):e1004345. PMID: 24901509.
    Citations: 21     Fields:    Translation:HumansCells
  69. Mattheisen M, Samuels JF, Wang Y, Greenberg BD, Fyer AJ, McCracken JT, Geller DA, Murphy DL, Knowles JA, Grados MA, Riddle MA, Rasmussen SA, McLaughlin NC, Nurmi EL, Askland KD, Qin HD, Cullen BA, Piacentini J, Pauls DL, Bienvenu OJ, Stewart SE, Liang KY, Goes FS, Maher B, Pulver AE, Shugart YY, Valle D, Lange C, Nestadt G. Genome-wide association study in obsessive-compulsive disorder: results from the OCGAS. Mol Psychiatry. 2015 Mar; 20(3):337-44. PMID: 24821223.
    Citations: 99     Fields:    Translation:HumansCells
  70. Al Chawa T, Ludwig KU, Fier H, Pötzsch B, Reich RH, Schmidt G, Braumann B, Daratsianos N, Böhmer AC, Schuencke H, Alblas M, Fricker N, Hoffmann P, Knapp M, Lange C, Nöthen MM, Mangold E. Nonsyndromic cleft lip with or without cleft palate: Increased burden of rare variants within Gremlin-1, a component of the bone morphogenetic protein 4 pathway. Birth Defects Res A Clin Mol Teratol. 2014 Jun; 100(6):493-8. PMID: 24706492.
    Citations: 9     Fields:    Translation:HumansCells
  71. Kaufmann SH, Lange C, Rao M, Balaji KN, Lotze M, Schito M, Zumla AI, Maeurer M. Progress in tuberculosis vaccine development and host-directed therapies--a state of the art review. Lancet Respir Med. 2014 Apr; 2(4):301-20. PMID: 24717627.
    Citations: 78     Fields:    Translation:HumansCells
  72. McDonald ML, Diaz AA, Ross JC, San Jose Estepar R, Zhou L, Regan EA, Eckbo E, Muralidhar N, Come CE, Cho MH, Hersh CP, Lange C, Wouters E, Casaburi RH, Coxson HO, Macnee W, Rennard SI, Lomas DA, Agusti A, Celli BR, Black-Shinn JL, Kinney GL, Lutz SM, Hokanson JE, Silverman EK, Washko GR. Quantitative computed tomography measures of pectoralis muscle area and disease severity in chronic obstructive pulmonary disease. A cross-sectional study. Ann Am Thorac Soc. 2014 Mar; 11(3):326-34. PMID: 24558953.
    Citations: 56     Fields:    Translation:Humans
  73. Cho MH, McDonald ML, Zhou X, Mattheisen M, Castaldi PJ, Hersh CP, Demeo DL, Sylvia JS, Ziniti J, Laird NM, Lange C, Litonjua AA, Sparrow D, Casaburi R, Barr RG, Regan EA, Make BJ, Hokanson JE, Lutz S, Dudenkov TM, Farzadegan H, Hetmanski JB, Tal-Singer R, Lomas DA, Bakke P, Gulsvik A, Crapo JD, Silverman EK, Beaty TH. Risk loci for chronic obstructive pulmonary disease: a genome-wide association study and meta-analysis. Lancet Respir Med. 2014 Mar; 2(3):214-25. PMID: 24621683.
    Citations: 134     Fields:    Translation:Humans
  74. Won S, Kim Y, Lange C. On rare-variant analysis in population-based designs: decomposing the likelihood to two informative components. Hum Hered. 2013; 76(2):76-85. PMID: 24434864.
    Citations:    Fields:    Translation:Humans
  75. Won S, Kwon MS, Mattheisen M, Park S, Park C, Kihara D, Cichon S, Ophoff R, Nöthen MM, Rietschel M, Baur M, Uitterlinden AG, Hofmann A, Lange C. Efficient strategy for detecting gene × gene joint action and its application in schizophrenia. Genet Epidemiol. 2014 Jan; 38(1):60-71. PMID: 24272960.
    Citations: 3     Fields:    Translation:Humans
  76. Lutz SM, Vansteelandt S, Lange C. Testing for direct genetic effects using a screening step in family-based association studies. Front Genet. 2013; 4:243. PMID: 24312120.
    Citations: 2     
  77. Qiao D, Cho MH, Fier H, Bakke PS, Gulsvik A, Silverman EK, Lange C. On the simultaneous association analysis of large genomic regions: a massive multi-locus association test. Bioinformatics. 2014 Jan 15; 30(2):157-64. PMID: 24262215.
    Citations: 2     Fields:    Translation:HumansCells
  78. Swanson DM, Blacker D, Alchawa T, Ludwig KU, Mangold E, Lange C. Properties of permutation-based gene tests and controlling type 1 error using a summary statistic based gene test. BMC Genet. 2013 Nov 07; 14:108. PMID: 24199751.
    Citations: 2     Fields:    Translation:Humans
  79. Chang SC, Pauls DL, Lange C, Sasanfar R, Santangelo SL. Sex-specific association of a common variant of the XG gene with autism spectrum disorders. . 2013 Oct; 162B(7):742-50. PMID: 24132906.
    Citations: 11     Translation:Humans
  80. Hooli BV, Kovacs-Vajna ZM, Mullin K, Blumenthal MA, Mattheisen M, Zhang C, Lange C, Mohapatra G, Bertram L, Tanzi RE. Rare autosomal copy number variations in early-onset familial Alzheimer's disease. Mol Psychiatry. 2014 Jun; 19(6):676-81. PMID: 23752245.
    Citations: 31     Fields:    Translation:Humans
  81. Won S, Lange C. A general framework for robust and efficient association analysis in family-based designs: quantitative and dichotomous phenotypes. Stat Med. 2013 Nov 10; 32(25):4482-98. PMID: 23740776.
    Citations: 7     Fields:    Translation:Humans
  82. Qiao D, Mattheisen M, Lange C. On association analysis of rare variants under population substructure: an approach for the detection of subjects that can cause bias in the analysis--T opt: an outlier detection method. Genet Epidemiol. 2013 Jul; 37(5):431-9. PMID: 23674291.
    Citations:    Fields:    Translation:Humans
  83. Fung WL, Naylor MG, Bennett DA, Lange C, Blacker D. Principal components methods for narrow-sense heritability in the analysis of multidimensional longitudinal cognitive phenotypes. . 2013 Oct; 162B(7):770-8. PMID: 23650207.
    Citations: 1     Translation:Humans
  84. Liang F, Bond E, Sandgren KJ, Smed-Sörensen A, Rangaka MX, Lange C, Koup RA, McComsey GA, Lederman MM, Wilkinson RJ, Andersson J, Loré K. Dendritic cell recruitment in response to skin antigen tests in HIV-1-infected individuals correlates with the level of T-cell infiltration. AIDS. 2013 Apr 24; 27(7):1071-80. PMID: 23324660.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  85. Duan QL, Lasky-Su J, Himes BE, Qiu W, Litonjua AA, Damask A, Lazarus R, Klanderman B, Irvin CG, Peters SP, Hanrahan JP, Lima JJ, Martinez FD, Mauger D, Chinchilli VM, Soto-Quiros M, Avila L, Celedón JC, Lange C, Weiss ST, Tantisira KG. A genome-wide association study of bronchodilator response in asthmatics. Pharmacogenomics J. 2014 Feb; 14(1):41-7. PMID: 23508266.
    Citations: 15     Fields:    Translation:Humans
  86. Maslova E, Strøm M, Oken E, Campos H, Lange C, Gold D, Olsen SF. Fish intake during pregnancy and the risk of child asthma and allergic rhinitis - longitudinal evidence from the Danish National Birth Cohort. Br J Nutr. 2013 Oct; 110(7):1313-25. PMID: 23473120.
    Citations: 11     Fields:    Translation:HumansAnimals
  87. Lutz S, Yip WK, Hokanson J, Laird N, Lange C. A general semi-parametric approach to the analysis of genetic association studies in population-based designs. BMC Genet. 2013 Feb 28; 14:13. PMID: 23448186.
    Citations: 1     Fields:    Translation:Humans
  88. Siedlinski M, Tingley D, Lipman PJ, Cho MH, Litonjua AA, Sparrow D, Bakke P, Gulsvik A, Lomas DA, Anderson W, Kong X, Rennard SI, Beaty TH, Hokanson JE, Crapo JD, Lange C, Silverman EK. Dissecting direct and indirect genetic effects on chronic obstructive pulmonary disease (COPD) susceptibility. Hum Genet. 2013 Apr; 132(4):431-41. PMID: 23299987.
    Citations: 33     Fields:    Translation:HumansCTClinical Trials
  89. Kalsdorf B, Skolimowska KH, Scriba TJ, Dawson R, Dheda K, Wood K, Hofmeister J, Hanekom WA, Lange C, Wilkinson RJ. Relationship between chemokine receptor expression, chemokine levels and HIV-1 replication in the lungs of persons exposed to Mycobacterium tuberculosis. Eur J Immunol. 2013 Feb; 43(2):540-9. PMID: 23147374.
    Citations: 10     Fields:    Translation:HumansCells
  90. Lasky-Su J, Himes BE, Raby BA, Klanderman BJ, Sylvia JS, Lange C, Melen E, Martinez FD, Israel E, Gauderman J, Gilliland F, Sleiman P, Hakonarson H, Celedón JC, Soto-Quiros M, Avila L, Lima JJ, Irvin CG, Peters SP, Boushey H, Chinchilli VM, Mauger D, Tantisira K, Weiss ST. HLA-DQ strikes again: genome-wide association study further confirms HLA-DQ in the diagnosis of asthma among adults. Clin Exp Allergy. 2012 Dec; 42(12):1724-33. PMID: 23181788.
    Citations: 29     Fields:    Translation:Humans
  91. Nasser E, Mangold E, Tradowsky DC, Fier H, Becker J, Boehmer AC, Herberz R, Fricker N, Barth S, Wahle P, Nowak S, Reutter H, Reich RH, Lauster C, Braumann B, Kreusch T, Hemprich A, Pötzsch B, Hoffmann P, Kramer FJ, Knapp M, Lange C, Nöthen MM, Ludwig KU. Resequencing of VAX1 in patients with nonsyndromic cleft lip with or without cleft palate. Birth Defects Res A Clin Mol Teratol. 2012 Nov; 94(11):925-33. PMID: 23081944.
    Citations: 5     Fields:    Translation:HumansCells
  92. Fier H, Won S, Prokopenko D, AlChawa T, Ludwig KU, Fimmers R, Silverman EK, Pagano M, Mangold E, Lange C. 'Location, Location, Location': a spatial approach for rare variant analysis and an application to a study on non-syndromic cleft lip with or without cleft palate. Bioinformatics. 2012 Dec 01; 28(23):3027-33. PMID: 23044548.
    Citations: 8     Fields:    Translation:HumansCells
  93. Ludwig KU, Mangold E, Herms S, Nowak S, Reutter H, Paul A, Becker J, Herberz R, AlChawa T, Nasser E, Böhmer AC, Mattheisen M, Alblas MA, Barth S, Kluck N, Lauster C, Braumann B, Reich RH, Hemprich A, Pötzsch S, Blaumeiser B, Daratsianos N, Kreusch T, Murray JC, Marazita ML, Ruczinski I, Scott AF, Beaty TH, Kramer FJ, Wienker TF, Steegers-Theunissen RP, Rubini M, Mossey PA, Hoffmann P, Lange C, Cichon S, Propping P, Knapp M, Nöthen MM. Genome-wide meta-analyses of nonsyndromic cleft lip with or without cleft palate identify six new risk loci. Nat Genet. 2012 Sep; 44(9):968-71. PMID: 22863734.
    Citations: 121     Fields:    Translation:Humans
  94. Vansteelandt S, Lange C. Causation and causal inference for genetic effects. Hum Genet. 2012 Oct; 131(10):1665-76. PMID: 22864952.
    Citations: 6     Fields:    Translation:Humans
  95. Qiao D, Yip WK, Lange C. Handling the data management needs of high-throughput sequencing data: SpeedGene, a compression algorithm for the efficient storage of genetic data. BMC Bioinformatics. 2012 May 16; 13:100. PMID: 22591016.
    Citations: 7     Fields:    
  96. Adhikari K, AlChawa T, Ludwig K, Mangold E, Laird N, Lange C. Is it rare or common? Genet Epidemiol. 2012 Jul; 36(5):419-29. PMID: 22549767.
    Citations: 1     Fields:    Translation:Humans
  97. Mühleisen TW, Mattheisen M, Strohmaier J, Degenhardt F, Priebe L, Schultz CC, Breuer R, Meier S, Hoffmann P, Rivandeneira F, Hofman A, Uitterlinden AG, Moebus S, Gieger C, Emeny R, Ladwig KH, Wichmann HE, Schwarz M, Kammerer-Ciernioch J, Schlösser RG, Nenadic I, Sauer H, Mössner R, Maier W, Rujescu D, Lange C, Ophoff RA, Schulze TG, Rietschel M, Nöthen MM, Cichon S. Association between schizophrenia and common variation in neurocan (NCAN), a genetic risk factor for bipolar disorder. Schizophr Res. 2012 Jun; 138(1):69-73. PMID: 22497794.
    Citations: 40     Fields:    Translation:Humans
  98. Hooli BV, Mohapatra G, Mattheisen M, Parrado AR, Roehr JT, Shen Y, Gusella JF, Moir R, Saunders AJ, Lange C, Tanzi RE, Bertram L. Role of common and rare APP DNA sequence variants in Alzheimer disease. Neurology. 2012 Apr 17; 78(16):1250-7. PMID: 22491860.
    Citations: 27     Fields:    Translation:Humans
  99. Degenhardt F, Priebe L, Herms S, Mattheisen M, Mühleisen TW, Meier S, Moebus S, Strohmaier J, Groß M, Breuer R, Lange C, Hoffmann P, Meyer-Lindenberg A, Heinz A, Walter H, Lucae S, Wolf C, Müller-Myhsok B, Holsboer F, Maier W, Rietschel M, Nöthen MM, Cichon S. Association between copy number variants in 16p11.2 and major depressive disorder in a German case-control sample. . 2012 Apr; 159B(3):263-73. PMID: 22344817.
    Citations: 17     Translation:HumansCells
  100. Won S, Lu Q, Bertram L, Tanzi RE, Lange C. On the meta-analysis of genome-wide association studies: a robust and efficient approach to combine population and family-based studies. Hum Hered. 2012; 73(1):35-46. PMID: 22261799.
    Citations: 3     Fields:    Translation:Humans
  101. Lipman PJ, Yip WK, AlChawa T, Ludwig KU, Mangold E, Lange C. On the analysis of sequence data: testing for disease susceptibility loci using patterns of linkage disequilibrium. Genet Epidemiol. 2011 Dec; 35(8):880-6. PMID: 22125225.
    Citations: 1     Fields:    Translation:Humans
  102. Sebro R, Lange C, Laird NM, Rogus JJ, Risch NJ. Differentiating population stratification from genotyping error using family data. Ann Hum Genet. 2012 Jan; 76(1):42-52. PMID: 22111716.
    Citations: 1     Fields:    Translation:Humans
  103. Cho MH, Castaldi PJ, Wan ES, Siedlinski M, Hersh CP, Demeo DL, Himes BE, Sylvia JS, Klanderman BJ, Ziniti JP, Lange C, Litonjua AA, Sparrow D, Regan EA, Make BJ, Hokanson JE, Murray T, Hetmanski JB, Pillai SG, Kong X, Anderson WH, Tal-Singer R, Lomas DA, Coxson HO, Edwards LD, MacNee W, Vestbo J, Yates JC, Agusti A, Calverley PM, Celli B, Crim C, Rennard S, Wouters E, Bakke P, Gulsvik A, Crapo JD, Beaty TH, Silverman EK. A genome-wide association study of COPD identifies a susceptibility locus on chromosome 19q13. Hum Mol Genet. 2012 Feb 15; 21(4):947-57. PMID: 22080838.
    Citations: 117     Fields:    Translation:HumansCells
  104. Tantisira KG, Lasky-Su J, Harada M, Murphy A, Litonjua AA, Himes BE, Lange C, Lazarus R, Sylvia J, Klanderman B, Duan QL, Qiu W, Hirota T, Martinez FD, Mauger D, Sorkness C, Szefler S, Lazarus SC, Lemanske RF, Peters SP, Lima JJ, Nakamura Y, Tamari M, Weiss ST. Genomewide association between GLCCI1 and response to glucocorticoid therapy in asthma. N Engl J Med. 2011 Sep 29; 365(13):1173-83. PMID: 21991891.
    Citations: 115     Fields:    Translation:Humans
  105. Andresen E, Günther G, Bullwinkel J, Lange C, Heine H. Increased expression of beta-defensin 1 (DEFB1) in chronic obstructive pulmonary disease. PLoS One. 2011; 6(7):e21898. PMID: 21818276.
    Citations: 21     Fields:    Translation:HumansCells
  106. Lipman PJ, Lange C. CGene: an R package for implementation of causal genetic analyses. Eur J Hum Genet. 2011 Dec; 19(12):1292-4. PMID: 21731061.
    Citations: 3     Fields:    Translation:Humans
  107. Uciechowski P, Imhoff H, Lange C, Meyer CG, Browne EN, Kirsten DK, Schröder AK, Schaaf B, Al-Lahham A, Reinert RR, Reiling N, Haase H, Hatzmann A, Fleischer D, Heussen N, Kleines M, Rink L. Susceptibility to tuberculosis is associated with TLR1 polymorphisms resulting in a lack of TLR1 cell surface expression. J Leukoc Biol. 2011 Aug; 90(2):377-88. PMID: 21642391.
    Citations: 32     Fields:    Translation:HumansCells
  108. Himes BE, Klanderman B, Ziniti J, Senter-Sylvia J, Soto-Quiros ME, Avila L, Celedón JC, Lange C, Mariani TJ, Lasky-Su J, Hersh CP, Raby BA, Silverman EK, Weiss ST, DeMeo DL. Association of SERPINE2 with asthma. Chest. 2011 Sep; 140(3):667-674. PMID: 21436250.
    Citations: 7     Fields:    Translation:Humans
  109. Hoffmann TJ, Vansteelandt S, Lange C, Silverman EK, DeMeo DL, Laird NM. Combining disease models to test for gene-environment interaction in nuclear families. Biometrics. 2011 Dec; 67(4):1260-70. PMID: 21401569.
    Citations: 2     Fields:    Translation:Humans
  110. Lipman PJ, Cho MH, Bakke P, Gulsvik A, Kong X, Lomas DA, Anderson W, Silverman EK, Lange C. On the follow-up of genome-wide association studies: an overall test for the most promising SNPs. Genet Epidemiol. 2011 Jul; 35(5):303-9. PMID: 21374717.
    Citations: 2     Fields:    Translation:Humans
  111. Andresen E, Lange C, Strodthoff D, Goldmann T, Fischer N, Sahly H, Branscheid D, Heine H. S100A7/psoriasin expression in the human lung: unchanged in patients with COPD, but upregulated upon positive S. aureus detection. BMC Pulm Med. 2011 Feb 15; 11:10. PMID: 21324122.
    Citations: 7     Fields:    Translation:HumansCells
  112. Ionita-Laza I, Buxbaum JD, Laird NM, Lange C. A new testing strategy to identify rare variants with either risk or protective effect on disease. PLoS Genet. 2011 Feb 03; 7(2):e1001289. PMID: 21304886.
    Citations: 89     Fields:    Translation:Humans
  113. Yip WK, Lange C. Quantitative trait prediction based on genetic marker-array data, a simulation study. Bioinformatics. 2011 Mar 15; 27(6):745-8. PMID: 21285022.
    Citations: 4     Fields:    Translation:Humans
  114. Amos CI, Lange C. Family-based designs. IARC Sci Publ. 2011; (163):261-80. PMID: 22997867.
    Citations:    Fields:    Translation:Humans
  115. Lipman PJ, Liu KY, Muehlschlegel JD, Body S, Lange C. Inferring genetic causal effects on survival data with associated endo-phenotypes. Genet Epidemiol. 2011 Feb; 35(2):119-24. PMID: 21254219.
    Citations: 4     Fields:    Translation:Humans
  116. Chang SC, Pauls DL, Lange C, Sasanfar R, Santangelo SL. Common genetic variation in the GAD1 gene and the entire family of DLX homeobox genes and autism spectrum disorders. . 2011 Mar; 156(2):233-9. PMID: 21302352.
    Citations: 8     Translation:Humans
  117. Sebro R, Hoffman TJ, Lange C, Rogus JJ, Risch NJ. Testing for non-random mating: evidence for ancestry-related assortative mating in the Framingham heart study. Genet Epidemiol. 2010 Nov; 34(7):674-9. PMID: 20842694.
    Citations: 16     Fields:    Translation:Humans
  118. Wan ES, Cho MH, Boutaoui N, Klanderman BJ, Sylvia JS, Ziniti JP, Won S, Lange C, Pillai SG, Anderson WH, Kong X, Lomas DA, Bakke PS, Gulsvik A, Regan EA, Murphy JR, Make BJ, Crapo JD, Wouters EF, Celli BR, Silverman EK, DeMeo DL. Genome-wide association analysis of body mass in chronic obstructive pulmonary disease. Am J Respir Cell Mol Biol. 2011 Aug; 45(2):304-10. PMID: 21037115.
    Citations: 19     Fields:    Translation:Humans
  119. Murphy A, Chu JH, Xu M, Carey VJ, Lazarus R, Liu A, Szefler SJ, Strunk R, Demuth K, Castro M, Hansel NN, Diette GB, Vonakis BM, Adkinson NF, Klanderman BJ, Senter-Sylvia J, Ziniti J, Lange C, Pastinen T, Raby BA. Mapping of numerous disease-associated expression polymorphisms in primary peripheral blood CD4+ lymphocytes. Hum Mol Genet. 2010 Dec 01; 19(23):4745-57. PMID: 20833654.
    Citations: 71     Fields:    Translation:Humans