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Christoph Lange, Ph.D.

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Research

Christoph's research interests are at the intersection of biostatistical methodology, numerical analysis, and computer science. Formally trained in all 3 areas, Christoph headed the analysis of the first genome-wide association study for complex diseases, the longitudinal analysis of BMI in the Framingham Heart Study. To address the challenges of this first wave of "big data" in genetics, Christoph's group developed statistical methodology to maximize power in such studies that minimize the effects of the multiple testing problem in GWAS and developed massively parallel software implementations for the analysis that also efficiently scale with the study size (PBAT software package). Christoph's group then successfully commercialized
the package in collaboration with GoldenHelix.

Currently, Christoph's group focuses on the statistical and computational challenges posed by whole-genome sequencing studies, e.g. powerful analysis methodology, clustering approaches of the genome, approaches to permutation testing, storage algorithm, etc.

Christoph is also involved in collaborative research in Asthma Genetics, COPD Genetics, and Alzheimer's Genetics.


Education

Ph.D., 2000, University of Reading, United Kingdom
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Research
research activities and funding
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
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  1. R56HG013314 (LANGE, CHRISTOPH) Sep 25, 2024 - Aug 31, 2025
    NIH
    Modernizing the family-based association testing (FBAT) approach and its software implementation in the FBAT-program
    Role: Principal Investigator
  2. R01HG008976 (LANGE, CHRISTOPH) Sep 27, 2016 - Jun 30, 2020
    NIH
    Preparing Association Analysis Software Tools for Next Generation Sequencing Data
    Role: Principal Investigator
  3. P01HL132825 (WEISS, SCOTT T) Sep 1, 2016 - Jul 31, 2021
    NIH
    Systems Biology of Airway Disease
    Role: Co-Principal Investigator
  4. R01MH087590 (LANGE, CHRISTOPH) Dec 1, 2009 - Nov 30, 2014
    NIH
    A New Approach to Mental Health Phenotypes in Family Genomewide Association
    Role: Principal Investigator
  5. R01MH081862 (LANGE, CHRISTOPH) Dec 1, 2007 - Mar 31, 2016
    NIH
    Novel Statistical Approaches to Mental Health Phenotype Analysis in GWA Studies
    Role: Principal Investigator

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© 2025 President and Fellows of Harvard College
Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.