Harvard Catalyst Profiles

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Donald Mark Coen, Ph.D.


The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R21AI141940 (COEN, DONALD M) Nov 9, 2018 - Oct 31, 2021
    Structural studies of herpesvirus DNA polymerases
    Role: Principal Investigator
  2. P01AI098681 (COEN, DONALD M) Jul 2, 2013 - Jul 31, 2024
    VIral and host mechanisms that tilt the HSV lytic/latent balance
    Role: Principal Investigator
  3. R21AI105896 (COEN, DONALD M) Mar 1, 2013 - Feb 29, 2016
    Antagonizing miRNAs in a strategy to cure HSV latency
    Role: Principal Investigator
  4. P01NS035138 (COEN, DONALD M) May 1, 1996 - Aug 31, 2012
    Mechanism of Latency of Herpes Simplex Virus
    Role: Principal Investigator
  5. U01AI033357 (COEN, DONALD M) Aug 1, 1992 - Jul 31, 1995
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Wilkie AR, Sharma M, Coughlin M, Pesola JM, Ericsson M, Lawler JL, Fernandez R, Coen DM. Human Cytomegalovirus Nuclear Egress Complex Subunit, UL53, Associates with Capsids and Myosin Va, but Is Not Important for Capsid Localization towards the Nuclear Periphery. Viruses. 2022 02 26; 14(3). PMID: 35336886; PMCID: PMC8949324.
    Citations: 1     Fields:    Translation:HumansCells
  2. Coen DM, Lawler JL, Abraham J. Herpesvirus DNA polymerase: Structures, functions, and mechanisms. Enzymes. 2021; 50:133-178. PMID: 34861935.
    Citations:    Fields:    Translation:HumansAnimalsCells
  3. Griffante G, Gugliesi F, Pasquero S, Dell'Oste V, Biolatti M, Salinger AJ, Mondal S, Thompson PR, Weerapana E, Lebbink RJ, Soppe JA, Stamminger T, Girault V, Pichlmair A, Oroszlán G, Coen DM, De Andrea M, Landolfo S. Human cytomegalovirus-induced host protein citrullination is crucial for viral replication. Nat Commun. 2021 06 23; 12(1):3910. PMID: 34162877; PMCID: PMC8222335.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  4. Chen H, Lawler JL, Filman DJ, Hogle JM, Coen DM. Resistance to a Nucleoside Analog Antiviral Drug from More Rapid Extension of Drug-Containing Primers. mBio. 2021 02 09; 12(1). PMID: 33563814.
    Citations: 1     Fields:    Translation:HumansCells
  5. Sun B, Yang X, Hou F, Yu X, Wang Q, Oh HS, Raja P, Pesola JM, Vanni EAH, McCarron S, Morris-Love J, Ng AHM, Church GM, Knipe DM, Coen DM, Pan D. Regulation of host and virus genes by neuronal miR-138 favours herpes simplex virus 1 latency. Nat Microbiol. 2021 05; 6(5):682-696. PMID: 33558653; PMCID: PMC8221016.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  6. Sen P, Wilkie AR, Ji F, Yang Y, Taylor IJ, Velazquez-Palafox M, Vanni EAH, Pesola JM, Fernandez R, Chen H, Morsett LM, Abels ER, Piper M, Lane RJ, Hickman SE, Means TK, Rosenberg ES, Sadreyev RI, Li B, Coen DM, Fishman JA, El Khoury J. Linking indirect effects of cytomegalovirus in transplantation to modulation of monocyte innate immune function. Sci Adv. 2020 04; 6(17):eaax9856. PMID: 32494628; PMCID: PMC7176434.
    Citations: 2     Fields:    
  7. Kim ET, Roche KL, Kulej K, Spruce LA, Seeholzer SH, Coen DM, Diaz-Griffero F, Murphy EA, Weitzman MD. SAMHD1 Modulates Early Steps during Human Cytomegalovirus Infection by Limiting NF-?B Activation. Cell Rep. 2019 07 09; 28(2):434-448.e6. PMID: 31291579.
    Citations: 21     Fields:    Translation:HumansCells
  8. Patel CD, Backes IM, Taylor SA, Jiang Y, Marchant A, Pesola JM, Coen DM, Knipe DM, Ackerman ME, Leib DA. Maternal immunization confers protection against neonatal herpes simplex mortality and behavioral morbidity. Sci Transl Med. 2019 04 10; 11(487). PMID: 30971454.
    Citations: 15     Fields:    Translation:HumansAnimalsCellsPHPublic Health
  9. Pan D, Li G, Morris-Love J, Qi S, Feng L, Mertens ME, Jurak I, Knipe DM, Coen DM. Herpes Simplex Virus 1 Lytic Infection Blocks MicroRNA (miRNA) Biogenesis at the Stage of Nuclear Export of Pre-miRNAs. mBio. 2019 02 12; 10(1). PMID: 30755517; PMCID: PMC6372804.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  10. Lawler JL, Coen DM. HSV-1 DNA polymerase 3'-5' exonuclease-deficient mutant D368A exhibits severely reduced viral DNA synthesis and polymerase expression. J Gen Virol. 2018 10; 99(10):1432-1437. PMID: 30176164; PMCID: PMC7011708.
    Citations: 3     Fields:    Translation:Cells
  11. Wilkie AR, Sharma M, Pesola JM, Ericsson M, Fernandez R, Coen DM. A Role for Myosin Va in Human Cytomegalovirus Nuclear Egress. J Virol. 2018 03 15; 92(6). PMID: 29298889; PMCID: PMC5827399.
    Citations: 6     Fields:    Translation:HumansCells
  12. Lawler JL, Mukherjee P, Coen DM. Herpes Simplex Virus 1 DNA Polymerase RNase H Activity Acts in a 3'-to-5' Direction and Is Dependent on the 3'-to-5' Exonuclease Active Site. J Virol. 2018 03 01; 92(5). PMID: 29237844; PMCID: PMC5809741.
    Citations: 4     Fields:    Translation:Cells
  13. Lee JS, Raja P, Pan D, Pesola JM, Coen DM, Knipe DM. CCCTC-Binding Factor Acts as a Heterochromatin Barrier on Herpes Simplex Viral Latent Chromatin and Contributes to Poised Latent Infection. mBio. 2018 02 06; 9(1). PMID: 29437926.
    Citations: 22     Fields:    Translation:HumansAnimalsCells
  14. Lutz G, Jurak I, Kim ET, Kim JY, Hackenberg M, Leader A, Stoller ML, Fekete DM, Weitzman MD, Coen DM, Wilson AC. Viral Ubiquitin Ligase Stimulates Selective Host MicroRNA Expression by Targeting ZEB Transcriptional Repressors. Viruses. 2017 08 07; 9(8). PMID: 28783105.
    Citations: 6     Fields:    Translation:HumansCells
  15. Lye MF, Wilkie AR, Filman DJ, Hogle JM, Coen DM. Getting to and through the inner nuclear membrane during herpesvirus nuclear egress. Curr Opin Cell Biol. 2017 06; 46:9-16. PMID: 28086162; PMCID: PMC5503802.
    Citations: 17     Fields:    Translation:HumansAnimalsCells
  16. Pan D, Pesola JM, Li G, McCarron S, Coen DM. Mutations Inactivating Herpes Simplex Virus 1 MicroRNA miR-H2 Do Not Detectably Increase ICP0 Gene Expression in Infected Cultured Cells or Mouse Trigeminal Ganglia. J Virol. 2017 Jan 15; 91(2). PMID: 27847363; PMCID: PMC5215319.
    Citations: 15     Fields:    Translation:HumansAnimalsCells
  17. Chen H, Coseno M, Ficarro SB, Mansueto MS, Komazin-Meredith G, Boissel S, Filman DJ, Marto JA, Hogle JM, Coen DM. A Small Covalent Allosteric Inhibitor of Human Cytomegalovirus DNA Polymerase Subunit Interactions. ACS Infect Dis. 2017 02 10; 3(2):112-118. PMID: 28183184; PMCID: PMC5480311.
    Citations: 5     Fields:    Translation:HumansCells
  18. Polachek WS, Moshrif HF, Franti M, Coen DM, Sreenu VB, Strang BL. High-Throughput Small Interfering RNA Screening Identifies Phosphatidylinositol 3-Kinase Class II Alpha as Important for Production of Human Cytomegalovirus Virions. J Virol. 2016 09 15; 90(18):8360-71. PMID: 27412598.
    Citations: 10     Fields:    Translation:HumansCells
  19. Wilkie AR, Lawler JL, Coen DM. A Role for Nuclear F-Actin Induction in Human Cytomegalovirus Nuclear Egress. mBio. 2016 08 23; 7(4). PMID: 27555312.
    Citations: 21     Fields:    Translation:HumansCells
  20. Rosato PC, Katzenell S, Pesola JM, North B, Coen DM, Leib DA. Neuronal IFN signaling is dispensable for the establishment of HSV-1 latency. Virology. 2016 10; 497:323-327. PMID: 27518540.
    Citations: 8     Fields:    Translation:AnimalsCells
  21. Chen H, Li C, Zemlicka J, Gentry BG, Bowlin TL, Coen DM. Potency and Stereoselectivity of Cyclopropavir Triphosphate Action on Human Cytomegalovirus DNA Polymerase. Antimicrob Agents Chemother. 2016 07; 60(7):4176-82. PMID: 27139481; PMCID: PMC4914631.
    Citations: 10     Fields:    Translation:Cells
  22. Raja P, Lee JS, Pan D, Pesola JM, Coen DM, Knipe DM. A Herpesviral Lytic Protein Regulates the Structure of Latent Viral Chromatin. mBio. 2016 05 17; 7(3). PMID: 27190217.
    Citations: 26     Fields:    Translation:AnimalsCells
  23. Colgrove RC, Liu X, Griffiths A, Raja P, Deluca NA, Newman RM, Coen DM, Knipe DM. History and genomic sequence analysis of the herpes simplex virus 1 KOS and KOS1.1 sub-strains. Virology. 2016 Jan; 487:215-21. PMID: 26547038.
    Citations: 17     Fields:    Translation:AnimalsCells
  24. Lye MF, Sharma M, El Omari K, Filman DJ, Schuermann JP, Hogle JM, Coen DM. Unexpected features and mechanism of heterodimer formation of a herpesvirus nuclear egress complex. EMBO J. 2015 Dec 02; 34(23):2937-52. PMID: 26511021.
    Citations: 45     Fields:    Translation:Cells
  25. Sharma M, Kamil JP, Coen DM. Preparation of the Human Cytomegalovirus Nuclear Egress Complex and Associated Proteins. Methods Enzymol. 2016; 569:517-26. PMID: 26778574; PMCID: PMC5304453.
    Citations: 7     Fields:    Translation:HumansCells
  26. Leigh KE, Sharma M, Mansueto MS, Boeszoermenyi A, Filman DJ, Hogle JM, Wagner G, Coen DM, Arthanari H. Structure of a herpesvirus nuclear egress complex subunit reveals an interaction groove that is essential for viral replication. Proc Natl Acad Sci U S A. 2015 Jul 21; 112(29):9010-5. PMID: 26150520; PMCID: PMC4517201.
    Citations: 35     Fields:    Translation:HumansAnimalsCells
  27. Chen H, Beardsley GP, Coen DM. Mechanism of ganciclovir-induced chain termination revealed by resistant viral polymerase mutants with reduced exonuclease activity. Proc Natl Acad Sci U S A. 2014 Dec 09; 111(49):17462-7. PMID: 25422422; PMCID: PMC4267342.
    Citations: 21     Fields:    Translation:Cells
  28. Sharma M, Bender BJ, Kamil JP, Lye MF, Pesola JM, Reim NI, Hogle JM, Coen DM. Human cytomegalovirus UL97 phosphorylates the viral nuclear egress complex. J Virol. 2015 Jan; 89(1):523-34. PMID: 25339763.
    Citations: 34     Fields:    Translation:HumansCells
  29. Bender BJ, Coen DM, Strang BL. Dynamic and nucleolin-dependent localization of human cytomegalovirus UL84 to the periphery of viral replication compartments and nucleoli. J Virol. 2014 Oct; 88(20):11738-47. PMID: 25078694.
    Citations: 18     Fields:    Translation:HumansCells
  30. Yan Z, Bryant KF, Gregory SM, Angelova M, Dreyfus DH, Zhao XZ, Coen DM, Burke TR, Knipe DM. HIV integrase inhibitors block replication of alpha-, beta-, and gammaherpesviruses. mBio. 2014 Jul 01; 5(4):e01318-14. PMID: 24987091.
    Citations: 16     Fields:    Translation:HumansCells
  31. Sharma M, Coen DM. Comparison of effects of inhibitors of viral and cellular protein kinases on human cytomegalovirus disruption of nuclear lamina and nuclear egress. J Virol. 2014 Sep; 88(18):10982-5. PMID: 24965476.
    Citations: 13     Fields:    Translation:HumansCells
  32. Pan D, Flores O, Umbach JL, Pesola JM, Bentley P, Rosato PC, Leib DA, Cullen BR, Coen DM. A neuron-specific host microRNA targets herpes simplex virus-1 ICP0 expression and promotes latency. Cell Host Microbe. 2014 Apr 09; 15(4):446-56. PMID: 24721573.
    Citations: 75     Fields:    Translation:HumansAnimalsCells
  33. Terrell SL, Pesola JM, Coen DM. Roles of conserved residues within the pre-NH2-terminal domain of herpes simplex virus 1 DNA polymerase in replication and latency in mice. J Gen Virol. 2014 Apr; 95(Pt 4):940-947. PMID: 24413420.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  34. Jurak I, Hackenberg M, Kim JY, Pesola JM, Everett RD, Preston CM, Wilson AC, Coen DM. Expression of herpes simplex virus 1 microRNAs in cell culture models of quiescent and latent infection. J Virol. 2014 Feb; 88(4):2337-9. PMID: 24307587; PMCID: PMC3911564.
    Citations: 23     Fields:    Translation:HumansAnimalsCells
  35. Sharma M, Kamil JP, Coughlin M, Reim NI, Coen DM. Human cytomegalovirus UL50 and UL53 recruit viral protein kinase UL97, not protein kinase C, for disruption of nuclear lamina and nuclear egress in infected cells. J Virol. 2014 Jan; 88(1):249-62. PMID: 24155370.
    Citations: 43     Fields:    Translation:HumansCells
  36. Pan D, Kaye SB, Hopkins M, Kirwan R, Hart IJ, Coen DM. Common and new acyclovir resistant herpes simplex virus-1 mutants causing bilateral recurrent herpetic keratitis in an immunocompetent patient. J Infect Dis. 2014 Feb 01; 209(3):345-9. PMID: 23945375; PMCID: PMC3883165.
    Citations: 13     Fields:    Translation:HumansCells
  37. Reim NI, Kamil JP, Wang D, Lin A, Sharma M, Ericsson M, Pesola JM, Golan DE, Coen DM. Inactivation of retinoblastoma protein does not overcome the requirement for human cytomegalovirus UL97 in lamina disruption and nuclear egress. J Virol. 2013 May; 87(9):5019-27. PMID: 23427156.
    Citations: 17     Fields:    Translation:HumansCells
  38. Cliffe AR, Coen DM, Knipe DM. Kinetics of facultative heterochromatin and polycomb group protein association with the herpes simplex viral genome during establishment of latent infection. mBio. 2013 Jan 15; 4(1). PMID: 23322639.
    Citations: 50     Fields:    Translation:AnimalsCells
  39. Weller SK, Coen DM. Herpes simplex viruses: mechanisms of DNA replication. Cold Spring Harb Perspect Biol. 2012 Sep 01; 4(9):a013011. PMID: 22952399.
    Citations: 99     Fields:    Translation:Cells
  40. Pan D, Coen DM. Net -1 frameshifting on a noncanonical sequence in a herpes simplex virus drug-resistant mutant is stimulated by nonstop mRNA. Proc Natl Acad Sci U S A. 2012 Sep 11; 109(37):14852-7. PMID: 22927407.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  41. Terrell SL, Coen DM. The pre-NH(2)-terminal domain of the herpes simplex virus 1 DNA polymerase catalytic subunit is required for efficient viral replication. J Virol. 2012 Oct; 86(20):11057-65. PMID: 22875965.
    Citations: 10     Fields:    Translation:AnimalsCells
  42. Strang BL, Bender BJ, Sharma M, Pesola JM, Sanders RL, Spector DH, Coen DM. A mutation deleting sequences encoding the amino terminus of human cytomegalovirus UL84 impairs interaction with UL44 and capsid localization. J Virol. 2012 Oct; 86(20):11066-77. PMID: 22855486.
    Citations: 15     Fields:    Translation:HumansCells
  43. Jurak I, Silverstein LB, Sharma M, Coen DM. Herpes simplex virus is equipped with RNA- and protein-based mechanisms to repress expression of ATRX, an effector of intrinsic immunity. J Virol. 2012 Sep; 86(18):10093-102. PMID: 22787211.
    Citations: 40     Fields:    Translation:HumansAnimalsCells
  44. Strang BL, Boulant S, Kirchhausen T, Coen DM. Host cell nucleolin is required to maintain the architecture of human cytomegalovirus replication compartments. mBio. 2012; 3(1). PMID: 22318319.
    Citations: 25     Fields:    Translation:HumansCells
  45. Pan D, Coen DM. Quantification and analysis of thymidine kinase expression from acyclovir-resistant G-string insertion and deletion mutants in herpes simplex virus-infected cells. J Virol. 2012 Apr; 86(8):4518-26. PMID: 22301158.
    Citations: 13     Fields:    Translation:HumansAnimalsCells
  46. Strang BL, Boulant S, Chang L, Knipe DM, Kirchhausen T, Coen DM. Human cytomegalovirus UL44 concentrates at the periphery of replication compartments, the site of viral DNA synthesis. J Virol. 2012 Feb; 86(4):2089-95. PMID: 22156516.
    Citations: 32     Fields:    Translation:HumansCells
  47. Coen DM, Whitley RJ. Antiviral drugs and antiviral drug resistance. Curr Opin Virol. 2011 Dec; 1(6):545-7. PMID: 22440912.
    Citations: 5     Fields:    Translation:Humans
  48. Kramer MF, Jurak I, Pesola JM, Boissel S, Knipe DM, Coen DM. Herpes simplex virus 1 microRNAs expressed abundantly during latent infection are not essential for latency in mouse trigeminal ganglia. Virology. 2011 Sep 01; 417(2):239-47. PMID: 21782205.
    Citations: 43     Fields:    Translation:AnimalsCells
  49. Silva LA, Strang BL, Lin EW, Kamil JP, Coen DM. Sites and roles of phosphorylation of the human cytomegalovirus DNA polymerase subunit UL44. Virology. 2011 Sep 01; 417(2):268-80. PMID: 21784501.
    Citations: 14     Fields:    Translation:HumansCells
  50. Jurak I, Griffiths A, Coen DM. Mammalian alphaherpesvirus miRNAs. Biochim Biophys Acta. 2011 Nov-Dec; 1809(11-12):641-53. PMID: 21736960.
    Citations: 13     Fields:    Translation:HumansAnimalsCells
  51. Kamil JP, Coen DM. HATs on for drug resistance. Cell Host Microbe. 2011 Feb 17; 9(2):85-7. PMID: 21320689.
    Citations: 3     Fields:    
  52. Silva LA, Loregian A, Pari GS, Strang BL, Coen DM. The carboxy-terminal segment of the human cytomegalovirus DNA polymerase accessory subunit UL44 is crucial for viral replication. J Virol. 2010 Nov; 84(21):11563-8. PMID: 20739543.
    Citations: 9     Fields:    Translation:HumansCells
  53. Tran K, Kamil JP, Coen DM, Spector DH. Inactivation and disassembly of the anaphase-promoting complex during human cytomegalovirus infection is associated with degradation of the APC5 and APC4 subunits and does not require UL97-mediated phosphorylation of Cdh1. J Virol. 2010 Oct; 84(20):10832-43. PMID: 20686030.
    Citations: 25     Fields:    Translation:HumansCells
  54. Gentry BG, Kamil JP, Coen DM, Zemlicka J, Drach JC. Stereoselective phosphorylation of cyclopropavir by pUL97 and competitive inhibition by maribavir. Antimicrob Agents Chemother. 2010 Aug; 54(8):3093-8. PMID: 20547817; PMCID: PMC2916337.
    Citations: 26     Fields:    Translation:HumansAnimalsCells
  55. Strang BL, Geballe AP, Coen DM. Association of human cytomegalovirus proteins IRS1 and TRS1 with the viral DNA polymerase accessory subunit UL44. J Gen Virol. 2010 Sep; 91(Pt 9):2167-75. PMID: 20444996.
    Citations: 24     Fields:    Translation:HumansCells
  56. Coen D. Priscilla Schaffer (1941-2009): a stalwart herpesvirologist. J Virol. 2010 Jul; 84(13):6265-7. PMID: 20427529.
    Citations:    Fields:    Translation:HumansCells
  57. Strang BL, Coen DM. Interaction of the human cytomegalovirus uracil DNA glycosylase UL114 with the viral DNA polymerase catalytic subunit UL54. J Gen Virol. 2010 Aug; 91(Pt 8):2029-2033. PMID: 20410316.
    Citations: 12     Fields:    Translation:HumansCells
  58. Jurak I, Kramer MF, Mellor JC, van Lint AL, Roth FP, Knipe DM, Coen DM. Numerous conserved and divergent microRNAs expressed by herpes simplex viruses 1 and 2. J Virol. 2010 May; 84(9):4659-72. PMID: 20181707.
    Citations: 85     Fields:    Translation:HumansAnimalsCells
  59. Strang BL, Boulant S, Coen DM. Nucleolin associates with the human cytomegalovirus DNA polymerase accessory subunit UL44 and is necessary for efficient viral replication. J Virol. 2010 Feb; 84(4):1771-84. PMID: 20007282.
    Citations: 42     Fields:    Translation:HumansCells
  60. Baltz JL, Filman DJ, Ciustea M, Silverman JE, Lautenschlager CL, Coen DM, Ricciardi RP, Hogle JM. The crystal structure of PF-8, the DNA polymerase accessory subunit from Kaposi's sarcoma-associated herpesvirus. J Virol. 2009 Dec; 83(23):12215-28. PMID: 19759157.
    Citations: 7     Fields:    Translation:HumansCells
  61. Kamil JP, Hume AJ, Jurak I, Münger K, Kalejta RF, Coen DM. Human papillomavirus 16 E7 inactivator of retinoblastoma family proteins complements human cytomegalovirus lacking UL97 protein kinase. Proc Natl Acad Sci U S A. 2009 Sep 29; 106(39):16823-8. PMID: 19805380.
    Citations: 29     Fields:    Translation:HumansCells
  62. Jiang C, Komazin-Meredith G, Tian W, Coen DM, Hwang CB. Mutations that increase DNA binding by the processivity factor of herpes simplex virus affect virus production and DNA replication fidelity. J Virol. 2009 Aug; 83(15):7573-80. PMID: 19474109.
    Citations: 9     Fields:    Translation:AnimalsCells
  63. Strang BL, Sinigalia E, Silva LA, Coen DM, Loregian A. Analysis of the association of the human cytomegalovirus DNA polymerase subunit UL44 with the viral DNA replication factor UL84. J Virol. 2009 Aug; 83(15):7581-9. PMID: 19457994.
    Citations: 23     Fields:    Translation:HumansCells
  64. Hamirally S, Kamil JP, Ndassa-Colday YM, Lin AJ, Jahng WJ, Baek MC, Noton S, Silva LA, Simpson-Holley M, Knipe DM, Golan DE, Marto JA, Coen DM. Viral mimicry of Cdc2/cyclin-dependent kinase 1 mediates disruption of nuclear lamina during human cytomegalovirus nuclear egress. PLoS Pathog. 2009 Jan; 5(1):e1000275. PMID: 19165338.
    Citations: 120     Fields:    Translation:HumansCells
  65. Sam MD, Evans BT, Coen DM, Hogle JM. Biochemical, biophysical, and mutational analyses of subunit interactions of the human cytomegalovirus nuclear egress complex. J Virol. 2009 Apr; 83(7):2996-3006. PMID: 19153235.
    Citations: 32     Fields:    Translation:HumansCells
  66. Sinigalia E, Alvisi G, Mercorelli B, Coen DM, Pari GS, Jans DA, Ripalti A, Palù G, Loregian A. Role of homodimerization of human cytomegalovirus DNA polymerase accessory protein UL44 in origin-dependent DNA replication in cells. J Virol. 2008 Dec; 82(24):12574-9. PMID: 18842734; PMCID: PMC2593364.
    Citations: 13     Fields:    Translation:HumansAnimalsCells
  67. Komazin-Meredith G, Petrella RJ, Santos WL, Filman DJ, Hogle JM, Verdine GL, Karplus M, Coen DM. The human cytomegalovirus UL44 C clamp wraps around DNA. Structure. 2008 Aug 06; 16(8):1214-25. PMID: 18682223.
    Citations: 18     Fields:    Translation:HumansCells
  68. Bryant KF, Macari ER, Malik N, Boyce M, Yuan J, Coen DM. ICP34.5-dependent and -independent activities of salubrinal in herpes simplex virus-1 infected cells. Virology. 2008 Sep 30; 379(2):197-204. PMID: 18684481.
    Citations: 15     Fields:    Translation:AnimalsCells
  69. Komazin-Meredith G, Mirchev R, Golan DE, van Oijen AM, Coen DM. Hopping of a processivity factor on DNA revealed by single-molecule assays of diffusion. Proc Natl Acad Sci U S A. 2008 Aug 05; 105(31):10721-6. PMID: 18658237.
    Citations: 37     Fields:    Translation:Cells
  70. Umbach JL, Kramer MF, Jurak I, Karnowski HW, Coen DM, Cullen BR. MicroRNAs expressed by herpes simplex virus 1 during latent infection regulate viral mRNAs. Nature. 2008 Aug 07; 454(7205):780-3. PMID: 18596690; PMCID: PMC2666538.
    Citations: 390     Fields:    Translation:HumansAnimalsCells
  71. Hume AJ, Finkel JS, Kamil JP, Coen DM, Culbertson MR, Kalejta RF. Phosphorylation of retinoblastoma protein by viral protein with cyclin-dependent kinase function. Science. 2008 May 09; 320(5877):797-9. PMID: 18467589.
    Citations: 124     Fields:    Translation:HumansCells
  72. Komazin-Meredith G, Santos WL, Filman DJ, Hogle JM, Verdine GL, Coen DM. The positively charged surface of herpes simplex virus UL42 mediates DNA binding. J Biol Chem. 2008 Mar 07; 283(10):6154-61. PMID: 18178550.
    Citations: 19     Fields:    Translation:Cells
  73. Bryant KF, Coen DM. Inhibition of translation by a short element in the 5' leader of the herpes simplex virus 1 DNA polymerase transcript. J Virol. 2008 Jan; 82(1):77-85. PMID: 17959669.
    Citations: 1     Fields:    Translation:AnimalsCells
  74. Jiang C, Hwang YT, Wang G, Randell JC, Coen DM, Hwang CB. Herpes simplex virus mutants with multiple substitutions affecting DNA binding of UL42 are impaired for viral replication and DNA synthesis. J Virol. 2007 Nov; 81(21):12077-9. PMID: 17715219; PMCID: PMC2168780.
    Citations: 8     Fields:    Translation:AnimalsCells
  75. Kamil JP, Coen DM. Human cytomegalovirus protein kinase UL97 forms a complex with the tegument phosphoprotein pp65. J Virol. 2007 Oct; 81(19):10659-68. PMID: 17634236; PMCID: PMC2045453.
    Citations: 50     Fields:    Translation:HumansCells
  76. Loregian A, Sinigalia E, Mercorelli B, Palù G, Coen DM. Binding parameters and thermodynamics of the interaction of the human cytomegalovirus DNA polymerase accessory protein, UL44, with DNA: implications for the processivity mechanism. Nucleic Acids Res. 2007; 35(14):4779-91. PMID: 17617644; PMCID: PMC1950537.
    Citations: 20     Fields:    Translation:Cells
  77. Dodson AW, Taylor TJ, Knipe DM, Coen DM. Inhibitors of the sodium potassium ATPase that impair herpes simplex virus replication identified via a chemical screening approach. Virology. 2007 Sep 30; 366(2):340-8. PMID: 17544048.
    Citations: 31     Fields:    Translation:AnimalsCells
  78. Besecker MI, Furness CL, Coen DM, Griffiths A. Expression of extremely low levels of thymidine kinase from an acyclovir-resistant herpes simplex virus mutant supports reactivation from latently infected mouse trigeminal ganglia. J Virol. 2007 Aug; 81(15):8356-60. PMID: 17522225; PMCID: PMC1951311.
    Citations: 7     Fields:    Translation:AnimalsCells
  79. Pesola JM, Coen DM. In vivo fitness and virulence of a drug-resistant herpes simplex virus 1 mutant. J Gen Virol. 2007 May; 88(Pt 5):1410-1414. PMID: 17412967.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  80. Jiang C, Hwang YT, Randell JC, Coen DM, Hwang CB. Mutations that decrease DNA binding of the processivity factor of the herpes simplex virus DNA polymerase reduce viral yield, alter the kinetics of viral DNA replication, and decrease the fidelity of DNA replication. J Virol. 2007 Apr; 81(7):3495-502. PMID: 17229696; PMCID: PMC1866068.
    Citations: 12     Fields:    Translation:AnimalsCells
  81. Kramer MF, Coen DM. Enzymatic amplification of DNA by PCR: standard procedures and optimization. Curr Protoc Cytom. 2006 Aug; Appendix 3:Appendix 3K. PMID: 18770830.
    Citations: 5     Fields:    Translation:Cells
  82. Griffiths A, Link MA, Furness CL, Coen DM. Low-level expression and reversion both contribute to reactivation of herpes simplex virus drug-resistant mutants with mutations on homopolymeric sequences in thymidine kinase. J Virol. 2006 Jul; 80(13):6568-74. PMID: 16775343; PMCID: PMC1488940.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  83. Cui C, Griffiths A, Li G, Silva LM, Kramer MF, Gaasterland T, Wang XJ, Coen DM. Prediction and identification of herpes simplex virus 1-encoded microRNAs. J Virol. 2006 Jun; 80(11):5499-508. PMID: 16699030.
    Citations: 123     Fields:    Translation:AnimalsCells
  84. Shogan B, Kruse L, Mulamba GB, Hu A, Coen DM. Virucidal activity of a GT-rich oligonucleotide against herpes simplex virus mediated by glycoprotein B. J Virol. 2006 May; 80(10):4740-7. PMID: 16641267.
    Citations: 16     Fields:    Translation:AnimalsCells
  85. Loregian A, Coen DM. Selective anti-cytomegalovirus compounds discovered by screening for inhibitors of subunit interactions of the viral polymerase. Chem Biol. 2006 Feb; 13(2):191-200. PMID: 16492567.
    Citations: 33     Fields:    Translation:HumansCells
  86. Appleton BA, Brooks J, Loregian A, Filman DJ, Coen DM, Hogle JM. Crystal structure of the cytomegalovirus DNA polymerase subunit UL44 in complex with the C terminus from the catalytic subunit. Differences in structure and function relative to unliganded UL44. J Biol Chem. 2006 Feb 24; 281(8):5224-32. PMID: 16371349.
    Citations: 30     Fields:    Translation:HumansCells
  87. Pesola JM, Zhu J, Knipe DM, Coen DM. Herpes simplex virus 1 immediate-early and early gene expression during reactivation from latency under conditions that prevent infectious virus production. J Virol. 2005 Dec; 79(23):14516-25. PMID: 16282451; PMCID: PMC1287588.
    Citations: 51     Fields:    Translation:AnimalsCells
  88. Wang QY, Zhou C, Johnson KE, Colgrove RC, Coen DM, Knipe DM. Herpesviral latency-associated transcript gene promotes assembly of heterochromatin on viral lytic-gene promoters in latent infection. Proc Natl Acad Sci U S A. 2005 Nov 01; 102(44):16055-9. PMID: 16247011; PMCID: PMC1266038.
    Citations: 157     Fields:    Translation:AnimalsCells
  89. Bryant KF, Cox JC, Wang H, Hogle JM, Ellington AD, Coen DM. Binding of herpes simplex virus-1 US11 to specific RNA sequences. Nucleic Acids Res. 2005; 33(19):6090-100. PMID: 16246910; PMCID: PMC1266072.
    Citations: 14     Fields:    Translation:Cells
  90. Randell JC, Komazin G, Jiang C, Hwang CB, Coen DM. Effects of substitutions of arginine residues on the basic surface of herpes simplex virus UL42 support a role for DNA binding in processive DNA synthesis. J Virol. 2005 Sep; 79(18):12025-34. PMID: 16140778; PMCID: PMC1212618.
    Citations: 16     Fields:    Translation:Cells
  91. Griffiths A, Coen DM. An unusual internal ribosome entry site in the herpes simplex virus thymidine kinase gene. Proc Natl Acad Sci U S A. 2005 Jul 05; 102(27):9667-72. PMID: 15972803; PMCID: PMC1172279.
    Citations: 21     Fields:    Translation:HumansAnimalsCells
  92. Boyce M, Bryant KF, Jousse C, Long K, Harding HP, Scheuner D, Kaufman RJ, Ma D, Coen DM, Ron D, Yuan J. A selective inhibitor of eIF2alpha dephosphorylation protects cells from ER stress. Science. 2005 Feb 11; 307(5711):935-9. PMID: 15705855.
    Citations: 627     Fields:    Translation:AnimalsCells
  93. Cook WJ, Kramer MF, Walker RM, Burwell TJ, Holman HA, Coen DM, Knipe DM. Persistent expression of chemokine and chemokine receptor RNAs at primary and latent sites of herpes simplex virus 1 infection. Virol J. 2004 Sep 23; 1:5. PMID: 15507126; PMCID: PMC524517.
    Citations: 27     Fields:    Translation:AnimalsCells
  94. Loregian A, Appleton BA, Hogle JM, Coen DM. Specific residues in the connector loop of the human cytomegalovirus DNA polymerase accessory protein UL44 are crucial for interaction with the UL54 catalytic subunit. J Virol. 2004 Sep; 78(17):9084-92. PMID: 15308704; PMCID: PMC506919.
    Citations: 28     Fields:    Translation:HumansCells
  95. Appleton BA, Loregian A, Filman DJ, Coen DM, Hogle JM. The cytomegalovirus DNA polymerase subunit UL44 forms a C clamp-shaped dimer. Mol Cell. 2004 Jul 23; 15(2):233-44. PMID: 15260974.
    Citations: 52     Fields:    Translation:HumansCells
  96. Baek MC, Krosky PM, Pearson A, Coen DM. Phosphorylation of the RNA polymerase II carboxyl-terminal domain in human cytomegalovirus-infected cells and in vitro by the viral UL97 protein kinase. Virology. 2004 Jun 20; 324(1):184-93. PMID: 15183065.
    Citations: 35     Fields:    Translation:HumansCells
  97. Pilger BD, Cui C, Coen DM. Identification of a small molecule that inhibits herpes simplex virus DNA Polymerase subunit interactions and viral replication. Chem Biol. 2004 May; 11(5):647-54. PMID: 15157875.
    Citations: 17     Fields:    Translation:HumansAnimalsCells
  98. Randell JC, Coen DM. The herpes simplex virus processivity factor, UL42, binds DNA as a monomer. J Mol Biol. 2004 Jan 09; 335(2):409-13. PMID: 14672651.
    Citations: 23     Fields:    Translation:HumansCells
  99. Loregian A, Appleton BA, Hogle JM, Coen DM. Residues of human cytomegalovirus DNA polymerase catalytic subunit UL54 that are necessary and sufficient for interaction with the accessory protein UL44. J Virol. 2004 Jan; 78(1):158-67. PMID: 14671097; PMCID: PMC303418.
    Citations: 29     Fields:    Translation:HumansCells
  100. Chen SH, Pearson A, Coen DM, Chen SH. Failure of thymidine kinase-negative herpes simplex virus to reactivate from latency following efficient establishment. J Virol. 2004 Jan; 78(1):520-3. PMID: 14671133; PMCID: PMC303395.
    Citations: 16     Fields:    Translation:AnimalsCells
  101. Pearson A, Knipe DM, Coen DM. ICP27 selectively regulates the cytoplasmic localization of a subset of viral transcripts in herpes simplex virus type 1-infected cells. J Virol. 2004 Jan; 78(1):23-32. PMID: 14671084; PMCID: PMC303382.
    Citations: 13     Fields:    Translation:AnimalsCells
  102. Kramer MF, Cook WJ, Roth FP, Zhu J, Holman H, Knipe DM, Coen DM. Latent herpes simplex virus infection of sensory neurons alters neuronal gene expression. J Virol. 2003 Sep; 77(17):9533-41. PMID: 12915567; PMCID: PMC187408.
    Citations: 34     Fields:    Translation:HumansAnimalsCells
  103. Krosky PM, Baek MC, Jahng WJ, Barrera I, Harvey RJ, Biron KK, Coen DM, Sethna PB. The human cytomegalovirus UL44 protein is a substrate for the UL97 protein kinase. J Virol. 2003 Jul; 77(14):7720-7. PMID: 12829811; PMCID: PMC161957.
    Citations: 50     Fields:    Translation:HumansAnimalsCells
  104. Griffiths A, Chen SH, Horsburgh BC, Coen DM. Translational compensation of a frameshift mutation affecting herpes simplex virus thymidine kinase is sufficient to permit reactivation from latency. J Virol. 2003 Apr; 77(8):4703-9. PMID: 12663777; PMCID: PMC152167.
    Citations: 20     Fields:    Translation:HumansAnimalsCells
  105. Coen DM, Schaffer PA. Antiherpesvirus drugs: a promising spectrum of new drugs and drug targets. Nat Rev Drug Discov. 2003 Apr; 2(4):278-88. PMID: 12669027.
    Citations: 48     Fields:    Translation:HumansCells
  106. Kramer M, Riley J, Spoering A, Coen D, Knipe D. Effect of immunization on herpes simplex virus type 1 latent infection in the trigeminal ganglion. Curr Eye Res. 2003 Mar-Apr; 26(3-4):185-94. PMID: 12815546.
    Citations:    Fields:    Translation:AnimalsCellsPHPublic Health
  107. Griffiths A, Coen DM. High-frequency phenotypic reversion and pathogenicity of an acyclovir-resistant herpes simplex virus mutant. J Virol. 2003 Feb; 77(3):2282-6. PMID: 12525666; PMCID: PMC140925.
    Citations: 15     Fields:    Translation:AnimalsCells
  108. Krosky PM, Baek MC, Coen DM. The human cytomegalovirus UL97 protein kinase, an antiviral drug target, is required at the stage of nuclear egress. J Virol. 2003 Jan; 77(2):905-14. PMID: 12502806; PMCID: PMC140798.
    Citations: 106     Fields:    Translation:Cells
  109. Baek MC, Krosky PM, Coen DM. Relationship between autophosphorylation and phosphorylation of exogenous substrates by the human cytomegalovirus UL97 protein kinase. J Virol. 2002 Dec; 76(23):11943-52. PMID: 12414936; PMCID: PMC136897.
    Citations: 27     Fields:    Translation:HumansAnimalsCells
  110. Kramer MF, Coen DM. The polymerase chain reaction. Curr Protoc Protein Sci. 2002 Nov; Appendix 4:A.4J.1-A.4J.8. PMID: 18429219.
    Citations: 1     Fields:    Translation:Animals
  111. Pearson A, Coen DM. Identification, localization, and regulation of expression of the UL24 protein of herpes simplex virus type 1. J Virol. 2002 Nov; 76(21):10821-8. PMID: 12368325; PMCID: PMC136619.