Harvard Catalyst Profiles
Contact, publication, and social network information about Harvard faculty and fellows.
Home
About
Overview
Open Source Software
Help
History (1)
Coen, Donald
See All Pages
Find People
Find Everything
Login
to
edit your profile
(add a photo, education, awards, etc.), search
student opportunities
, and
create reports
.
Edit My Profile
My Person List (
0
)
Opportunity Search
Return to Top
Donald Mark Coen, Ph.D.
Title
Professor of Biological Chemistry and Molecular Pharmacology
Institution
Harvard Medical School
Department
BCMP
Address
Harvard Medical School
C215
250 Longwood Ave
Boston MA 02115
Phone
617/432-1691
Fax
617/432-5205
vCard
Download vCard
(
login for email
)
research activities and funding
|
selected publications
|
Research
research activities and funding
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can
login
to make corrections and additions.
Most Recent
|
List All
R21AI141940
(COEN, DONALD M)
Nov 9, 2018 - Oct 31, 2021
NIH
Structural studies of herpesvirus DNA polymerases
Role: Principal Investigator
P01AI098681
(COEN, DONALD M)
Jul 2, 2013 - Jul 31, 2024
NIH
VIral and host mechanisms that tilt the HSV lytic/latent balance
Role: Principal Investigator
R21AI105896
(COEN, DONALD M)
Mar 1, 2013 - Feb 29, 2016
NIH
Antagonizing miRNAs in a strategy to cure HSV latency
Role: Principal Investigator
P01NS035138
(COEN, DONALD M)
May 1, 1996 - Aug 31, 2012
NIH
Mechanism of Latency of Herpes Simplex Virus
Role: Principal Investigator
U01AI033357
(COEN, DONALD M)
Aug 1, 1992 - Jul 31, 1995
NIH
ANTICMV DRUGS VIA MOLECULAR STUDIES OF CMV DRUG TARGETS
Role: Principal Investigator
R01AI026126
(COEN, DONALD M)
Sep 30, 1988 - Aug 31, 2012
NIH
Mechanisms Regulating HSV TK Expression During Infection
Role: Principal Investigator
R01AI026077
(COEN, DONALD M)
Apr 1, 1988 - Feb 28, 2021
NIH
Human Cytomegalovirus Nuclear Egress: Molecular Mechanisms and Drug Targeting
Role: Principal Investigator
R56AI026077
(COEN, DONALD M)
Apr 1, 1988 - Sep 28, 2010
NIH
Human Cytomegalovirus Nuclear Egress: Molecular Mechanisms and Drug Targeting
Role: Principal Investigator
U01AI026077
(COEN, DONALD M)
Apr 1, 1988 - Jun 30, 1999
NIH
COMBINED APPROACH TO TARGETED ANTIHERPESVIRUS DRUGS
Role: Principal Investigator
R56AI019838
(COEN, DONALD M)
Apr 1, 1983 - Apr 30, 2020
NIH
Molecular Genetics of HSV DNA Polymerase Gene
Role: Principal Investigator
R01AI019838
(COEN, DONALD M)
Apr 1, 1983 - Apr 30, 2017
NIH
Molecular Genetics of HSV DNA Polymerase Gene
Role: Principal Investigator
T32GM007306
(GOLAN, DAVID E.)
Jul 1, 1975 - Jul 31, 2019
NIH
Training in Pharmacological Sciences
Role: Co-Principal Investigator
Bibliographic
selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can
login
to make corrections and additions.
Newest
|
Oldest
|
Most Cited
|
Most Discussed
|
Timeline
|
Field Summary
|
Plain Text
PMC Citations
indicate the number of times the publication was cited by articles in PubMed Central, and the
Altmetric
score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.)
Fields
are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication.
Translation
tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
Wilkie AR, Sharma M, Coughlin M,
Pesola JM
,
Ericsson M
, Lawler JL, Fernandez R,
Coen DM
. Human Cytomegalovirus Nuclear Egress Complex Subunit, UL53, Associates with Capsids and Myosin Va, but Is Not Important for Capsid Localization towards the Nuclear Periphery. Viruses. 2022 02 26; 14(3).
PMID:
35336886
; PMCID:
PMC8949324
.
Citations:
1
Fields:
Vir
Virology
Translation:
Humans
Cells
Coen DM
, Lawler JL,
Abraham J
. Herpesvirus DNA polymerase: Structures, functions, and mechanisms. Enzymes. 2021; 50:133-178.
PMID:
34861935
.
Citations:
Fields:
Bio
Biochemistry
Mol
Molecular Biology
Translation:
Humans
Animals
Cells
Griffante G, Gugliesi F, Pasquero S, Dell'Oste V, Biolatti M, Salinger AJ, Mondal S, Thompson PR, Weerapana E, Lebbink RJ, Soppe JA, Stamminger T, Girault V, Pichlmair A, Oroszlán G,
Coen DM
, De Andrea M, Landolfo S. Human cytomegalovirus-induced host protein citrullination is crucial for viral replication. Nat Commun. 2021 06 23; 12(1):3910.
PMID:
34162877
; PMCID:
PMC8222335
.
Citations:
5
Fields:
Bio
Biology
Sci
Science
Translation:
Humans
Animals
Cells
Chen H, Lawler JL, Filman DJ,
Hogle JM
,
Coen DM
. Resistance to a Nucleoside Analog Antiviral Drug from More Rapid Extension of Drug-Containing Primers. mBio. 2021 02 09; 12(1).
PMID:
33563814
.
Citations:
1
Fields:
Mic
Microbiology
Translation:
Humans
Cells
Sun B, Yang X, Hou F, Yu X, Wang Q, Oh HS, Raja P,
Pesola JM
, Vanni EAH, McCarron S, Morris-Love J, Ng AHM, Church GM,
Knipe DM
,
Coen DM
, Pan D. Regulation of host and virus genes by neuronal miR-138 favours herpes simplex virus 1 latency. Nat Microbiol. 2021 05; 6(5):682-696.
PMID:
33558653
; PMCID:
PMC8221016
.
Citations:
10
Fields:
Mic
Microbiology
Par
Parasitology
Vir
Virology
Translation:
Humans
Animals
Cells
Sen P
, Wilkie AR, Ji F, Yang Y, Taylor IJ, Velazquez-Palafox M, Vanni EAH,
Pesola JM
, Fernandez R, Chen H, Morsett LM, Abels ER, Piper M, Lane RJ, Hickman SE, Means TK,
Rosenberg ES
,
Sadreyev RI
, Li B,
Coen DM
,
Fishman JA
, El Khoury J. Linking indirect effects of cytomegalovirus in transplantation to modulation of monocyte innate immune function. Sci Adv. 2020 04; 6(17):eaax9856.
PMID:
32494628
; PMCID:
PMC7176434
.
Citations:
2
Fields:
Sci
Science
Kim ET, Roche KL, Kulej K, Spruce LA, Seeholzer SH,
Coen DM
, Diaz-Griffero F, Murphy EA, Weitzman MD. SAMHD1 Modulates Early Steps during Human Cytomegalovirus Infection by Limiting NF-?B Activation. Cell Rep. 2019 07 09; 28(2):434-448.e6.
PMID:
31291579
.
Citations:
21
Fields:
Cel
Cell Biology
Mol
Molecular Biology
Translation:
Humans
Cells
Patel CD, Backes IM, Taylor SA, Jiang Y, Marchant A,
Pesola JM
,
Coen DM
,
Knipe DM
, Ackerman ME, Leib DA. Maternal immunization confers protection against neonatal herpes simplex mortality and behavioral morbidity. Sci Transl Med. 2019 04 10; 11(487).
PMID:
30971454
.
Citations:
15
Fields:
Med
Medicine (General)
Sci
Science
Translation:
Humans
Animals
Cells
PH
Public Health
Pan D, Li G, Morris-Love J, Qi S, Feng L, Mertens ME, Jurak I,
Knipe DM
,
Coen DM
. Herpes Simplex Virus 1 Lytic Infection Blocks MicroRNA (miRNA) Biogenesis at the Stage of Nuclear Export of Pre-miRNAs. mBio. 2019 02 12; 10(1).
PMID:
30755517
; PMCID:
PMC6372804
.
Citations:
12
Fields:
Mic
Microbiology
Translation:
Humans
Animals
Cells
Lawler JL,
Coen DM
. HSV-1 DNA polymerase 3'-5' exonuclease-deficient mutant D368A exhibits severely reduced viral DNA synthesis and polymerase expression. J Gen Virol. 2018 10; 99(10):1432-1437.
PMID:
30176164
; PMCID:
PMC7011708
.
Citations:
3
Fields:
Vir
Virology
Translation:
Cells
Wilkie AR, Sharma M,
Pesola JM
,
Ericsson M
, Fernandez R,
Coen DM
. A Role for Myosin Va in Human Cytomegalovirus Nuclear Egress. J Virol. 2018 03 15; 92(6).
PMID:
29298889
; PMCID:
PMC5827399
.
Citations:
6
Fields:
Vir
Virology
Translation:
Humans
Cells
Lawler JL, Mukherjee P,
Coen DM
. Herpes Simplex Virus 1 DNA Polymerase RNase H Activity Acts in a 3'-to-5' Direction and Is Dependent on the 3'-to-5' Exonuclease Active Site. J Virol. 2018 03 01; 92(5).
PMID:
29237844
; PMCID:
PMC5809741
.
Citations:
4
Fields:
Vir
Virology
Translation:
Cells
Lee JS, Raja P, Pan D,
Pesola JM
,
Coen DM
,
Knipe DM
. CCCTC-Binding Factor Acts as a Heterochromatin Barrier on Herpes Simplex Viral Latent Chromatin and Contributes to Poised Latent Infection. mBio. 2018 02 06; 9(1).
PMID:
29437926
.
Citations:
22
Fields:
Mic
Microbiology
Translation:
Humans
Animals
Cells
Lutz G, Jurak I, Kim ET, Kim JY, Hackenberg M, Leader A, Stoller ML, Fekete DM, Weitzman MD,
Coen DM
, Wilson AC. Viral Ubiquitin Ligase Stimulates Selective Host MicroRNA Expression by Targeting ZEB Transcriptional Repressors. Viruses. 2017 08 07; 9(8).
PMID:
28783105
.
Citations:
6
Fields:
Vir
Virology
Translation:
Humans
Cells
Lye MF, Wilkie AR, Filman DJ,
Hogle JM
,
Coen DM
. Getting to and through the inner nuclear membrane during herpesvirus nuclear egress. Curr Opin Cell Biol. 2017 06; 46:9-16.
PMID:
28086162
; PMCID:
PMC5503802
.
Citations:
17
Fields:
Cel
Cell Biology
Translation:
Humans
Animals
Cells
Pan D,
Pesola JM
, Li G, McCarron S,
Coen DM
. Mutations Inactivating Herpes Simplex Virus 1 MicroRNA miR-H2 Do Not Detectably Increase ICP0 Gene Expression in Infected Cultured Cells or Mouse Trigeminal Ganglia. J Virol. 2017 Jan 15; 91(2).
PMID:
27847363
; PMCID:
PMC5215319
.
Citations:
15
Fields:
Vir
Virology
Translation:
Humans
Animals
Cells
Chen H, Coseno M,
Ficarro SB
, Mansueto MS, Komazin-Meredith G, Boissel S, Filman DJ,
Marto JA
,
Hogle JM
,
Coen DM
. A Small Covalent Allosteric Inhibitor of Human Cytomegalovirus DNA Polymerase Subunit Interactions. ACS Infect Dis. 2017 02 10; 3(2):112-118.
PMID:
28183184
; PMCID:
PMC5480311
.
Citations:
5
Fields:
Ant
Anti-Infective Agents
Dru
Drug Therapy
Mic
Microbiology
Translation:
Humans
Cells
Polachek WS, Moshrif HF, Franti M,
Coen DM
, Sreenu VB, Strang BL. High-Throughput Small Interfering RNA Screening Identifies Phosphatidylinositol 3-Kinase Class II Alpha as Important for Production of Human Cytomegalovirus Virions. J Virol. 2016 09 15; 90(18):8360-71.
PMID:
27412598
.
Citations:
10
Fields:
Vir
Virology
Translation:
Humans
Cells
Wilkie AR, Lawler JL,
Coen DM
. A Role for Nuclear F-Actin Induction in Human Cytomegalovirus Nuclear Egress. mBio. 2016 08 23; 7(4).
PMID:
27555312
.
Citations:
21
Fields:
Mic
Microbiology
Translation:
Humans
Cells
Rosato PC, Katzenell S,
Pesola JM
, North B,
Coen DM
, Leib DA. Neuronal IFN signaling is dispensable for the establishment of HSV-1 latency. Virology. 2016 10; 497:323-327.
PMID:
27518540
.
Citations:
8
Fields:
Vir
Virology
Translation:
Animals
Cells
Chen H, Li C, Zemlicka J, Gentry BG, Bowlin TL,
Coen DM
. Potency and Stereoselectivity of Cyclopropavir Triphosphate Action on Human Cytomegalovirus DNA Polymerase. Antimicrob Agents Chemother. 2016 07; 60(7):4176-82.
PMID:
27139481
; PMCID:
PMC4914631
.
Citations:
10
Fields:
Ant
Anti-Infective Agents
Translation:
Cells
Raja P, Lee JS, Pan D,
Pesola JM
,
Coen DM
,
Knipe DM
. A Herpesviral Lytic Protein Regulates the Structure of Latent Viral Chromatin. mBio. 2016 05 17; 7(3).
PMID:
27190217
.
Citations:
26
Fields:
Mic
Microbiology
Translation:
Animals
Cells
Colgrove RC
, Liu X, Griffiths A, Raja P, Deluca NA, Newman RM,
Coen DM
,
Knipe DM
. History and genomic sequence analysis of the herpes simplex virus 1 KOS and KOS1.1 sub-strains. Virology. 2016 Jan; 487:215-21.
PMID:
26547038
.
Citations:
17
Fields:
Vir
Virology
Translation:
Animals
Cells
Lye MF, Sharma M, El Omari K, Filman DJ, Schuermann JP,
Hogle JM
,
Coen DM
. Unexpected features and mechanism of heterodimer formation of a herpesvirus nuclear egress complex. EMBO J. 2015 Dec 02; 34(23):2937-52.
PMID:
26511021
.
Citations:
45
Fields:
Bio
Biotechnology
Mol
Molecular Biology
Translation:
Cells
Sharma M, Kamil JP,
Coen DM
. Preparation of the Human Cytomegalovirus Nuclear Egress Complex and Associated Proteins. Methods Enzymol. 2016; 569:517-26.
PMID:
26778574
; PMCID:
PMC5304453
.
Citations:
7
Fields:
Bio
Biochemistry
Translation:
Humans
Cells
Leigh KE, Sharma M, Mansueto MS, Boeszoermenyi A, Filman DJ,
Hogle JM
,
Wagner G
,
Coen DM
,
Arthanari H
. Structure of a herpesvirus nuclear egress complex subunit reveals an interaction groove that is essential for viral replication. Proc Natl Acad Sci U S A. 2015 Jul 21; 112(29):9010-5.
PMID:
26150520
; PMCID:
PMC4517201
.
Citations:
35
Fields:
Sci
Science
Translation:
Humans
Animals
Cells
Chen H, Beardsley GP,
Coen DM
. Mechanism of ganciclovir-induced chain termination revealed by resistant viral polymerase mutants with reduced exonuclease activity. Proc Natl Acad Sci U S A. 2014 Dec 09; 111(49):17462-7.
PMID:
25422422
; PMCID:
PMC4267342
.
Citations:
21
Fields:
Sci
Science
Translation:
Cells
Sharma M, Bender BJ, Kamil JP, Lye MF,
Pesola JM
, Reim NI,
Hogle JM
,
Coen DM
. Human cytomegalovirus UL97 phosphorylates the viral nuclear egress complex. J Virol. 2015 Jan; 89(1):523-34.
PMID:
25339763
.
Citations:
34
Fields:
Vir
Virology
Translation:
Humans
Cells
Bender BJ,
Coen DM
, Strang BL. Dynamic and nucleolin-dependent localization of human cytomegalovirus UL84 to the periphery of viral replication compartments and nucleoli. J Virol. 2014 Oct; 88(20):11738-47.
PMID:
25078694
.
Citations:
18
Fields:
Vir
Virology
Translation:
Humans
Cells
Yan Z, Bryant KF, Gregory SM, Angelova M, Dreyfus DH, Zhao XZ,
Coen DM
, Burke TR,
Knipe DM
. HIV integrase inhibitors block replication of alpha-, beta-, and gammaherpesviruses. mBio. 2014 Jul 01; 5(4):e01318-14.
PMID:
24987091
.
Citations:
16
Fields:
Mic
Microbiology
Translation:
Humans
Cells
Sharma M,
Coen DM
. Comparison of effects of inhibitors of viral and cellular protein kinases on human cytomegalovirus disruption of nuclear lamina and nuclear egress. J Virol. 2014 Sep; 88(18):10982-5.
PMID:
24965476
.
Citations:
13
Fields:
Vir
Virology
Translation:
Humans
Cells
Pan D, Flores O, Umbach JL,
Pesola JM
, Bentley P, Rosato PC, Leib DA, Cullen BR,
Coen DM
. A neuron-specific host microRNA targets herpes simplex virus-1 ICP0 expression and promotes latency. Cell Host Microbe. 2014 Apr 09; 15(4):446-56.
PMID:
24721573
.
Citations:
75
Fields:
Mic
Microbiology
Translation:
Humans
Animals
Cells
Terrell SL,
Pesola JM
,
Coen DM
. Roles of conserved residues within the pre-NH2-terminal domain of herpes simplex virus 1 DNA polymerase in replication and latency in mice. J Gen Virol. 2014 Apr; 95(Pt 4):940-947.
PMID:
24413420
.
Citations:
4
Fields:
Vir
Virology
Translation:
Humans
Animals
Cells
Jurak I, Hackenberg M, Kim JY,
Pesola JM
, Everett RD, Preston CM, Wilson AC,
Coen DM
. Expression of herpes simplex virus 1 microRNAs in cell culture models of quiescent and latent infection. J Virol. 2014 Feb; 88(4):2337-9.
PMID:
24307587
; PMCID:
PMC3911564
.
Citations:
23
Fields:
Vir
Virology
Translation:
Humans
Animals
Cells
Sharma M, Kamil JP, Coughlin M, Reim NI,
Coen DM
. Human cytomegalovirus UL50 and UL53 recruit viral protein kinase UL97, not protein kinase C, for disruption of nuclear lamina and nuclear egress in infected cells. J Virol. 2014 Jan; 88(1):249-62.
PMID:
24155370
.
Citations:
43
Fields:
Vir
Virology
Translation:
Humans
Cells
Pan D, Kaye SB, Hopkins M, Kirwan R, Hart IJ,
Coen DM
. Common and new acyclovir resistant herpes simplex virus-1 mutants causing bilateral recurrent herpetic keratitis in an immunocompetent patient. J Infect Dis. 2014 Feb 01; 209(3):345-9.
PMID:
23945375
; PMCID:
PMC3883165
.
Citations:
13
Fields:
Com
Communicable Diseases
Translation:
Humans
Cells
Reim NI, Kamil JP, Wang D, Lin A, Sharma M,
Ericsson M
,
Pesola JM
,
Golan DE
,
Coen DM
. Inactivation of retinoblastoma protein does not overcome the requirement for human cytomegalovirus UL97 in lamina disruption and nuclear egress. J Virol. 2013 May; 87(9):5019-27.
PMID:
23427156
.
Citations:
17
Fields:
Vir
Virology
Translation:
Humans
Cells
Cliffe AR,
Coen DM
,
Knipe DM
. Kinetics of facultative heterochromatin and polycomb group protein association with the herpes simplex viral genome during establishment of latent infection. mBio. 2013 Jan 15; 4(1).
PMID:
23322639
.
Citations:
50
Fields:
Mic
Microbiology
Translation:
Animals
Cells
Weller SK,
Coen DM
. Herpes simplex viruses: mechanisms of DNA replication. Cold Spring Harb Perspect Biol. 2012 Sep 01; 4(9):a013011.
PMID:
22952399
.
Citations:
99
Fields:
Bio
Biology
Translation:
Cells
Pan D,
Coen DM
. Net -1 frameshifting on a noncanonical sequence in a herpes simplex virus drug-resistant mutant is stimulated by nonstop mRNA. Proc Natl Acad Sci U S A. 2012 Sep 11; 109(37):14852-7.
PMID:
22927407
.
Citations:
12
Fields:
Sci
Science
Translation:
Humans
Animals
Cells
Terrell SL,
Coen DM
. The pre-NH(2)-terminal domain of the herpes simplex virus 1 DNA polymerase catalytic subunit is required for efficient viral replication. J Virol. 2012 Oct; 86(20):11057-65.
PMID:
22875965
.
Citations:
10
Fields:
Vir
Virology
Translation:
Animals
Cells
Strang BL, Bender BJ, Sharma M,
Pesola JM
, Sanders RL, Spector DH,
Coen DM
. A mutation deleting sequences encoding the amino terminus of human cytomegalovirus UL84 impairs interaction with UL44 and capsid localization. J Virol. 2012 Oct; 86(20):11066-77.
PMID:
22855486
.
Citations:
15
Fields:
Vir
Virology
Translation:
Humans
Cells
Jurak I, Silverstein LB, Sharma M,
Coen DM
. Herpes simplex virus is equipped with RNA- and protein-based mechanisms to repress expression of ATRX, an effector of intrinsic immunity. J Virol. 2012 Sep; 86(18):10093-102.
PMID:
22787211
.
Citations:
40
Fields:
Vir
Virology
Translation:
Humans
Animals
Cells
Strang BL, Boulant S,
Kirchhausen T
,
Coen DM
. Host cell nucleolin is required to maintain the architecture of human cytomegalovirus replication compartments. mBio. 2012; 3(1).
PMID:
22318319
.
Citations:
25
Fields:
Mic
Microbiology
Translation:
Humans
Cells
Pan D,
Coen DM
. Quantification and analysis of thymidine kinase expression from acyclovir-resistant G-string insertion and deletion mutants in herpes simplex virus-infected cells. J Virol. 2012 Apr; 86(8):4518-26.
PMID:
22301158
.
Citations:
13
Fields:
Vir
Virology
Translation:
Humans
Animals
Cells
Strang BL, Boulant S, Chang L,
Knipe DM
,
Kirchhausen T
,
Coen DM
. Human cytomegalovirus UL44 concentrates at the periphery of replication compartments, the site of viral DNA synthesis. J Virol. 2012 Feb; 86(4):2089-95.
PMID:
22156516
.
Citations:
32
Fields:
Vir
Virology
Translation:
Humans
Cells
Coen DM
, Whitley RJ. Antiviral drugs and antiviral drug resistance. Curr Opin Virol. 2011 Dec; 1(6):545-7.
PMID:
22440912
.
Citations:
5
Fields:
Vir
Virology
Translation:
Humans
Kramer MF, Jurak I,
Pesola JM
, Boissel S,
Knipe DM
,
Coen DM
. Herpes simplex virus 1 microRNAs expressed abundantly during latent infection are not essential for latency in mouse trigeminal ganglia. Virology. 2011 Sep 01; 417(2):239-47.
PMID:
21782205
.
Citations:
43
Fields:
Vir
Virology
Translation:
Animals
Cells
Silva LA, Strang BL,
Lin EW
, Kamil JP,
Coen DM
. Sites and roles of phosphorylation of the human cytomegalovirus DNA polymerase subunit UL44. Virology. 2011 Sep 01; 417(2):268-80.
PMID:
21784501
.
Citations:
14
Fields:
Vir
Virology
Translation:
Humans
Cells
Jurak I, Griffiths A,
Coen DM
. Mammalian alphaherpesvirus miRNAs. Biochim Biophys Acta. 2011 Nov-Dec; 1809(11-12):641-53.
PMID:
21736960
.
Citations:
13
Fields:
Bio
Biochemistry
Bio
Biophysics
Translation:
Humans
Animals
Cells
Kamil JP,
Coen DM
. HATs on for drug resistance. Cell Host Microbe. 2011 Feb 17; 9(2):85-7.
PMID:
21320689
.
Citations:
3
Fields:
Mic
Microbiology
Silva LA, Loregian A, Pari GS, Strang BL,
Coen DM
. The carboxy-terminal segment of the human cytomegalovirus DNA polymerase accessory subunit UL44 is crucial for viral replication. J Virol. 2010 Nov; 84(21):11563-8.
PMID:
20739543
.
Citations:
9
Fields:
Vir
Virology
Translation:
Humans
Cells
Tran K, Kamil JP,
Coen DM
, Spector DH. Inactivation and disassembly of the anaphase-promoting complex during human cytomegalovirus infection is associated with degradation of the APC5 and APC4 subunits and does not require UL97-mediated phosphorylation of Cdh1. J Virol. 2010 Oct; 84(20):10832-43.
PMID:
20686030
.
Citations:
25
Fields:
Vir
Virology
Translation:
Humans
Cells
Gentry BG, Kamil JP,
Coen DM
, Zemlicka J, Drach JC. Stereoselective phosphorylation of cyclopropavir by pUL97 and competitive inhibition by maribavir. Antimicrob Agents Chemother. 2010 Aug; 54(8):3093-8.
PMID:
20547817
; PMCID:
PMC2916337
.
Citations:
26
Fields:
Ant
Anti-Infective Agents
Translation:
Humans
Animals
Cells
Strang BL, Geballe AP,
Coen DM
. Association of human cytomegalovirus proteins IRS1 and TRS1 with the viral DNA polymerase accessory subunit UL44. J Gen Virol. 2010 Sep; 91(Pt 9):2167-75.
PMID:
20444996
.
Citations:
24
Fields:
Vir
Virology
Translation:
Humans
Cells
Coen D
. Priscilla Schaffer (1941-2009): a stalwart herpesvirologist. J Virol. 2010 Jul; 84(13):6265-7.
PMID:
20427529
.
Citations:
Fields:
Vir
Virology
Translation:
Humans
Cells
Strang BL,
Coen DM
. Interaction of the human cytomegalovirus uracil DNA glycosylase UL114 with the viral DNA polymerase catalytic subunit UL54. J Gen Virol. 2010 Aug; 91(Pt 8):2029-2033.
PMID:
20410316
.
Citations:
12
Fields:
Vir
Virology
Translation:
Humans
Cells
Jurak I, Kramer MF, Mellor JC, van Lint AL, Roth FP,
Knipe DM
,
Coen DM
. Numerous conserved and divergent microRNAs expressed by herpes simplex viruses 1 and 2. J Virol. 2010 May; 84(9):4659-72.
PMID:
20181707
.
Citations:
85
Fields:
Vir
Virology
Translation:
Humans
Animals
Cells
Strang BL, Boulant S,
Coen DM
. Nucleolin associates with the human cytomegalovirus DNA polymerase accessory subunit UL44 and is necessary for efficient viral replication. J Virol. 2010 Feb; 84(4):1771-84.
PMID:
20007282
.
Citations:
42
Fields:
Vir
Virology
Translation:
Humans
Cells
Baltz JL, Filman DJ, Ciustea M, Silverman JE, Lautenschlager CL,
Coen DM
, Ricciardi RP,
Hogle JM
. The crystal structure of PF-8, the DNA polymerase accessory subunit from Kaposi's sarcoma-associated herpesvirus. J Virol. 2009 Dec; 83(23):12215-28.
PMID:
19759157
.
Citations:
7
Fields:
Vir
Virology
Translation:
Humans
Cells
Kamil JP, Hume AJ, Jurak I, Münger K, Kalejta RF,
Coen DM
. Human papillomavirus 16 E7 inactivator of retinoblastoma family proteins complements human cytomegalovirus lacking UL97 protein kinase. Proc Natl Acad Sci U S A. 2009 Sep 29; 106(39):16823-8.
PMID:
19805380
.
Citations:
29
Fields:
Sci
Science
Translation:
Humans
Cells
Jiang C, Komazin-Meredith G, Tian W,
Coen DM
, Hwang CB. Mutations that increase DNA binding by the processivity factor of herpes simplex virus affect virus production and DNA replication fidelity. J Virol. 2009 Aug; 83(15):7573-80.
PMID:
19474109
.
Citations:
9
Fields:
Vir
Virology
Translation:
Animals
Cells
Strang BL, Sinigalia E, Silva LA,
Coen DM
, Loregian A. Analysis of the association of the human cytomegalovirus DNA polymerase subunit UL44 with the viral DNA replication factor UL84. J Virol. 2009 Aug; 83(15):7581-9.
PMID:
19457994
.
Citations:
23
Fields:
Vir
Virology
Translation:
Humans
Cells
Hamirally S, Kamil JP, Ndassa-Colday YM, Lin AJ, Jahng WJ, Baek MC, Noton S, Silva LA, Simpson-Holley M,
Knipe DM
,
Golan DE
,
Marto JA
,
Coen DM
. Viral mimicry of Cdc2/cyclin-dependent kinase 1 mediates disruption of nuclear lamina during human cytomegalovirus nuclear egress. PLoS Pathog. 2009 Jan; 5(1):e1000275.
PMID:
19165338
.
Citations:
120
Fields:
Mic
Microbiology
Translation:
Humans
Cells
Sam MD, Evans BT,
Coen DM
,
Hogle JM
. Biochemical, biophysical, and mutational analyses of subunit interactions of the human cytomegalovirus nuclear egress complex. J Virol. 2009 Apr; 83(7):2996-3006.
PMID:
19153235
.
Citations:
32
Fields:
Vir
Virology
Translation:
Humans
Cells
Sinigalia E, Alvisi G, Mercorelli B,
Coen DM
, Pari GS, Jans DA, Ripalti A, Palù G, Loregian A. Role of homodimerization of human cytomegalovirus DNA polymerase accessory protein UL44 in origin-dependent DNA replication in cells. J Virol. 2008 Dec; 82(24):12574-9.
PMID:
18842734
; PMCID:
PMC2593364
.
Citations:
13
Fields:
Vir
Virology
Translation:
Humans
Animals
Cells
Komazin-Meredith G,
Petrella RJ
, Santos WL, Filman DJ,
Hogle JM
,
Verdine GL
, Karplus M,
Coen DM
. The human cytomegalovirus UL44 C clamp wraps around DNA. Structure. 2008 Aug 06; 16(8):1214-25.
PMID:
18682223
.
Citations:
18
Fields:
Bio
Biochemistry
Bio
Biotechnology
Mol
Molecular Biology
Translation:
Humans
Cells
Bryant KF, Macari ER, Malik N, Boyce M, Yuan J,
Coen DM
. ICP34.5-dependent and -independent activities of salubrinal in herpes simplex virus-1 infected cells. Virology. 2008 Sep 30; 379(2):197-204.
PMID:
18684481
.
Citations:
15
Fields:
Vir
Virology
Translation:
Animals
Cells
Komazin-Meredith G, Mirchev R,
Golan DE
, van Oijen AM,
Coen DM
. Hopping of a processivity factor on DNA revealed by single-molecule assays of diffusion. Proc Natl Acad Sci U S A. 2008 Aug 05; 105(31):10721-6.
PMID:
18658237
.
Citations:
37
Fields:
Sci
Science
Translation:
Cells
Umbach JL, Kramer MF, Jurak I, Karnowski HW,
Coen DM
, Cullen BR. MicroRNAs expressed by herpes simplex virus 1 during latent infection regulate viral mRNAs. Nature. 2008 Aug 07; 454(7205):780-3.
PMID:
18596690
; PMCID:
PMC2666538
.
Citations:
390
Fields:
Sci
Science
Translation:
Humans
Animals
Cells
Hume AJ, Finkel JS, Kamil JP,
Coen DM
, Culbertson MR, Kalejta RF. Phosphorylation of retinoblastoma protein by viral protein with cyclin-dependent kinase function. Science. 2008 May 09; 320(5877):797-9.
PMID:
18467589
.
Citations:
124
Fields:
Sci
Science
Translation:
Humans
Cells
Komazin-Meredith G, Santos WL, Filman DJ,
Hogle JM
,
Verdine GL
,
Coen DM
. The positively charged surface of herpes simplex virus UL42 mediates DNA binding. J Biol Chem. 2008 Mar 07; 283(10):6154-61.
PMID:
18178550
.
Citations:
19
Fields:
Bio
Biochemistry
Translation:
Cells
Bryant KF,
Coen DM
. Inhibition of translation by a short element in the 5' leader of the herpes simplex virus 1 DNA polymerase transcript. J Virol. 2008 Jan; 82(1):77-85.
PMID:
17959669
.
Citations:
1
Fields:
Vir
Virology
Translation:
Animals
Cells
Jiang C, Hwang YT, Wang G, Randell JC,
Coen DM
, Hwang CB. Herpes simplex virus mutants with multiple substitutions affecting DNA binding of UL42 are impaired for viral replication and DNA synthesis. J Virol. 2007 Nov; 81(21):12077-9.
PMID:
17715219
; PMCID:
PMC2168780
.
Citations:
8
Fields:
Vir
Virology
Translation:
Animals
Cells
Kamil JP,
Coen DM
. Human cytomegalovirus protein kinase UL97 forms a complex with the tegument phosphoprotein pp65. J Virol. 2007 Oct; 81(19):10659-68.
PMID:
17634236
; PMCID:
PMC2045453
.
Citations:
50
Fields:
Vir
Virology
Translation:
Humans
Cells
Loregian A, Sinigalia E, Mercorelli B, Palù G,
Coen DM
. Binding parameters and thermodynamics of the interaction of the human cytomegalovirus DNA polymerase accessory protein, UL44, with DNA: implications for the processivity mechanism. Nucleic Acids Res. 2007; 35(14):4779-91.
PMID:
17617644
; PMCID:
PMC1950537
.
Citations:
20
Fields:
Bio
Biochemistry
Translation:
Cells
Dodson AW, Taylor TJ,
Knipe DM
,
Coen DM
. Inhibitors of the sodium potassium ATPase that impair herpes simplex virus replication identified via a chemical screening approach. Virology. 2007 Sep 30; 366(2):340-8.
PMID:
17544048
.
Citations:
31
Fields:
Vir
Virology
Translation:
Animals
Cells
Besecker MI, Furness CL,
Coen DM
, Griffiths A. Expression of extremely low levels of thymidine kinase from an acyclovir-resistant herpes simplex virus mutant supports reactivation from latently infected mouse trigeminal ganglia. J Virol. 2007 Aug; 81(15):8356-60.
PMID:
17522225
; PMCID:
PMC1951311
.
Citations:
7
Fields:
Vir
Virology
Translation:
Animals
Cells
Pesola JM
,
Coen DM
. In vivo fitness and virulence of a drug-resistant herpes simplex virus 1 mutant. J Gen Virol. 2007 May; 88(Pt 5):1410-1414.
PMID:
17412967
.
Citations:
3
Fields:
Vir
Virology
Translation:
Humans
Animals
Cells
Jiang C, Hwang YT, Randell JC,
Coen DM
, Hwang CB. Mutations that decrease DNA binding of the processivity factor of the herpes simplex virus DNA polymerase reduce viral yield, alter the kinetics of viral DNA replication, and decrease the fidelity of DNA replication. J Virol. 2007 Apr; 81(7):3495-502.
PMID:
17229696
; PMCID:
PMC1866068
.
Citations:
12
Fields:
Vir
Virology
Translation:
Animals
Cells
Kramer MF,
Coen DM
. Enzymatic amplification of DNA by PCR: standard procedures and optimization. Curr Protoc Cytom. 2006 Aug; Appendix 3:Appendix 3K.
PMID:
18770830
.
Citations:
5
Fields:
Cel
Cell Biology
Translation:
Cells
Griffiths A, Link MA, Furness CL,
Coen DM
. Low-level expression and reversion both contribute to reactivation of herpes simplex virus drug-resistant mutants with mutations on homopolymeric sequences in thymidine kinase. J Virol. 2006 Jul; 80(13):6568-74.
PMID:
16775343
; PMCID:
PMC1488940
.
Citations:
12
Fields:
Vir
Virology
Translation:
Humans
Animals
Cells
Cui C, Griffiths A, Li G, Silva LM, Kramer MF, Gaasterland T, Wang XJ,
Coen DM
. Prediction and identification of herpes simplex virus 1-encoded microRNAs. J Virol. 2006 Jun; 80(11):5499-508.
PMID:
16699030
.
Citations:
123
Fields:
Vir
Virology
Translation:
Animals
Cells
Shogan B, Kruse L, Mulamba GB, Hu A,
Coen DM
. Virucidal activity of a GT-rich oligonucleotide against herpes simplex virus mediated by glycoprotein B. J Virol. 2006 May; 80(10):4740-7.
PMID:
16641267
.
Citations:
16
Fields:
Vir
Virology
Translation:
Animals
Cells
Loregian A,
Coen DM
. Selective anti-cytomegalovirus compounds discovered by screening for inhibitors of subunit interactions of the viral polymerase. Chem Biol. 2006 Feb; 13(2):191-200.
PMID:
16492567
.
Citations:
33
Fields:
Bio
Biochemistry
Bio
Biology
Che
Chemistry
Translation:
Humans
Cells
Appleton BA, Brooks J, Loregian A, Filman DJ,
Coen DM
,
Hogle JM
. Crystal structure of the cytomegalovirus DNA polymerase subunit UL44 in complex with the C terminus from the catalytic subunit. Differences in structure and function relative to unliganded UL44. J Biol Chem. 2006 Feb 24; 281(8):5224-32.
PMID:
16371349
.
Citations:
30
Fields:
Bio
Biochemistry
Translation:
Humans
Cells
Pesola JM
, Zhu J,
Knipe DM
,
Coen DM
. Herpes simplex virus 1 immediate-early and early gene expression during reactivation from latency under conditions that prevent infectious virus production. J Virol. 2005 Dec; 79(23):14516-25.
PMID:
16282451
; PMCID:
PMC1287588
.
Citations:
51
Fields:
Vir
Virology
Translation:
Animals
Cells
Wang QY,
Zhou C
, Johnson KE,
Colgrove RC
,
Coen DM
,
Knipe DM
. Herpesviral latency-associated transcript gene promotes assembly of heterochromatin on viral lytic-gene promoters in latent infection. Proc Natl Acad Sci U S A. 2005 Nov 01; 102(44):16055-9.
PMID:
16247011
; PMCID:
PMC1266038
.
Citations:
157
Fields:
Sci
Science
Translation:
Animals
Cells
Bryant KF, Cox JC, Wang H,
Hogle JM
, Ellington AD,
Coen DM
. Binding of herpes simplex virus-1 US11 to specific RNA sequences. Nucleic Acids Res. 2005; 33(19):6090-100.
PMID:
16246910
; PMCID:
PMC1266072
.
Citations:
14
Fields:
Bio
Biochemistry
Translation:
Cells
Randell JC, Komazin G, Jiang C, Hwang CB,
Coen DM
. Effects of substitutions of arginine residues on the basic surface of herpes simplex virus UL42 support a role for DNA binding in processive DNA synthesis. J Virol. 2005 Sep; 79(18):12025-34.
PMID:
16140778
; PMCID:
PMC1212618
.
Citations:
16
Fields:
Vir
Virology
Translation:
Cells
Griffiths A,
Coen DM
. An unusual internal ribosome entry site in the herpes simplex virus thymidine kinase gene. Proc Natl Acad Sci U S A. 2005 Jul 05; 102(27):9667-72.
PMID:
15972803
; PMCID:
PMC1172279
.
Citations:
21
Fields:
Sci
Science
Translation:
Humans
Animals
Cells
Boyce M, Bryant KF, Jousse C, Long K, Harding HP, Scheuner D, Kaufman RJ, Ma D,
Coen DM
, Ron D, Yuan J. A selective inhibitor of eIF2alpha dephosphorylation protects cells from ER stress. Science. 2005 Feb 11; 307(5711):935-9.
PMID:
15705855
.
Citations:
627
Fields:
Sci
Science
Translation:
Animals
Cells
Cook WJ, Kramer MF, Walker RM, Burwell TJ, Holman HA,
Coen DM
,
Knipe DM
. Persistent expression of chemokine and chemokine receptor RNAs at primary and latent sites of herpes simplex virus 1 infection. Virol J. 2004 Sep 23; 1:5.
PMID:
15507126
; PMCID:
PMC524517
.
Citations:
27
Fields:
Vir
Virology
Translation:
Animals
Cells
Loregian A, Appleton BA,
Hogle JM
,
Coen DM
. Specific residues in the connector loop of the human cytomegalovirus DNA polymerase accessory protein UL44 are crucial for interaction with the UL54 catalytic subunit. J Virol. 2004 Sep; 78(17):9084-92.
PMID:
15308704
; PMCID:
PMC506919
.
Citations:
28
Fields:
Vir
Virology
Translation:
Humans
Cells
Appleton BA, Loregian A, Filman DJ,
Coen DM
,
Hogle JM
. The cytomegalovirus DNA polymerase subunit UL44 forms a C clamp-shaped dimer. Mol Cell. 2004 Jul 23; 15(2):233-44.
PMID:
15260974
.
Citations:
52
Fields:
Cel
Cell Biology
Mol
Molecular Biology
Translation:
Humans
Cells
Baek MC, Krosky PM, Pearson A,
Coen DM
. Phosphorylation of the RNA polymerase II carboxyl-terminal domain in human cytomegalovirus-infected cells and in vitro by the viral UL97 protein kinase. Virology. 2004 Jun 20; 324(1):184-93.
PMID:
15183065
.
Citations:
35
Fields:
Vir
Virology
Translation:
Humans
Cells
Pilger BD, Cui C,
Coen DM
. Identification of a small molecule that inhibits herpes simplex virus DNA Polymerase subunit interactions and viral replication. Chem Biol. 2004 May; 11(5):647-54.
PMID:
15157875
.
Citations:
17
Fields:
Bio
Biochemistry
Bio
Biology
Che
Chemistry
Translation:
Humans
Animals
Cells
Randell JC,
Coen DM
. The herpes simplex virus processivity factor, UL42, binds DNA as a monomer. J Mol Biol. 2004 Jan 09; 335(2):409-13.
PMID:
14672651
.
Citations:
23
Fields:
Mol
Molecular Biology
Translation:
Humans
Cells
Loregian A, Appleton BA,
Hogle JM
,
Coen DM
. Residues of human cytomegalovirus DNA polymerase catalytic subunit UL54 that are necessary and sufficient for interaction with the accessory protein UL44. J Virol. 2004 Jan; 78(1):158-67.
PMID:
14671097
; PMCID:
PMC303418
.
Citations:
29
Fields:
Vir
Virology
Translation:
Humans
Cells
Chen SH, Pearson A,
Coen DM
, Chen SH. Failure of thymidine kinase-negative herpes simplex virus to reactivate from latency following efficient establishment. J Virol. 2004 Jan; 78(1):520-3.
PMID:
14671133
; PMCID:
PMC303395
.
Citations:
16
Fields:
Vir
Virology
Translation:
Animals
Cells
Pearson A,
Knipe DM
,
Coen DM
. ICP27 selectively regulates the cytoplasmic localization of a subset of viral transcripts in herpes simplex virus type 1-infected cells. J Virol. 2004 Jan; 78(1):23-32.
PMID:
14671084
; PMCID:
PMC303382
.
Citations:
13
Fields:
Vir
Virology
Translation:
Animals
Cells
Kramer MF, Cook WJ, Roth FP, Zhu J, Holman H,
Knipe DM
,
Coen DM
. Latent herpes simplex virus infection of sensory neurons alters neuronal gene expression. J Virol. 2003 Sep; 77(17):9533-41.
PMID:
12915567
; PMCID:
PMC187408
.
Citations:
34
Fields:
Vir
Virology
Translation:
Humans
Animals
Cells
Krosky PM, Baek MC, Jahng WJ, Barrera I, Harvey RJ, Biron KK,
Coen DM
, Sethna PB. The human cytomegalovirus UL44 protein is a substrate for the UL97 protein kinase. J Virol. 2003 Jul; 77(14):7720-7.
PMID:
12829811
; PMCID:
PMC161957
.
Citations:
50
Fields:
Vir
Virology
Translation:
Humans
Animals
Cells
Griffiths A, Chen SH, Horsburgh BC,
Coen DM
. Translational compensation of a frameshift mutation affecting herpes simplex virus thymidine kinase is sufficient to permit reactivation from latency. J Virol. 2003 Apr; 77(8):4703-9.
PMID:
12663777
; PMCID:
PMC152167
.
Citations:
20
Fields:
Vir
Virology
Translation:
Humans
Animals
Cells
Coen DM
, Schaffer PA. Antiherpesvirus drugs: a promising spectrum of new drugs and drug targets. Nat Rev Drug Discov. 2003 Apr; 2(4):278-88.
PMID:
12669027
.
Citations:
48
Fields:
Dru
Drug Therapy
Pha
Pharmacology
Translation:
Humans
Cells
Kramer M, Riley J, Spoering A,
Coen D
,
Knipe D
. Effect of immunization on herpes simplex virus type 1 latent infection in the trigeminal ganglion. Curr Eye Res. 2003 Mar-Apr; 26(3-4):185-94.
PMID:
12815546
.
Citations:
Fields:
Oph
Ophthalmology
Translation:
Animals
Cells
PH
Public Health
Griffiths A,
Coen DM
. High-frequency phenotypic reversion and pathogenicity of an acyclovir-resistant herpes simplex virus mutant. J Virol. 2003 Feb; 77(3):2282-6.
PMID:
12525666
; PMCID:
PMC140925
.
Citations:
15
Fields:
Vir
Virology
Translation:
Animals
Cells
Krosky PM, Baek MC,
Coen DM
. The human cytomegalovirus UL97 protein kinase, an antiviral drug target, is required at the stage of nuclear egress. J Virol. 2003 Jan; 77(2):905-14.
PMID:
12502806
; PMCID:
PMC140798
.
Citations:
106
Fields:
Vir
Virology
Translation:
Cells
Baek MC, Krosky PM,
Coen DM
. Relationship between autophosphorylation and phosphorylation of exogenous substrates by the human cytomegalovirus UL97 protein kinase. J Virol. 2002 Dec; 76(23):11943-52.
PMID:
12414936
; PMCID:
PMC136897
.
Citations:
27
Fields:
Vir
Virology
Translation:
Humans
Animals
Cells
Kramer MF,
Coen DM
. The polymerase chain reaction. Curr Protoc Protein Sci. 2002 Nov; Appendix 4:A.4J.1-A.4J.8.
PMID:
18429219
.
Citations:
1
Fields:
Bio
Biochemistry
Translation:
Animals
Pearson A,
Coen DM
. Identification, localization, and regulation of expression of the UL24 protein of herpes simplex virus type 1. J Virol. 2002 Nov; 76(21):10821-8.
PMID:
12368325
; PMCID:
PMC136619
.
Cita