Harvard Catalyst Profiles

Contact, publication, and social network information about Harvard faculty and fellows.

Rosalyn Mare Adam, Ph.D.


The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01DK127673 (LEE, RICHARD SANG-YONG) Sep 6, 2021 - Jun 30, 2026
    NIMBLE: Non-Invasive Markers of Bladder Deterioration
    Role: Co-Principal Investigator
  2. R21CA198722 (ADAM, ROSALYN M) Sep 6, 2016 - Aug 31, 2019
    Sh3gl2 and chemosensitivity of bladder cancer
    Role: Principal Investigator
  3. R01DK104641 (ADAM, ROSALYN M) Jun 13, 2016 - Feb 28, 2021
    The neuropilin 2 axis in smooth muscle contractility
    Role: Principal Investigator
  4. R13DK108605 (ADAM, ROSALYN M) Sep 14, 2015 - Aug 31, 2016
    The Environment-Gene Interface in Urologic Health and Disease
    Role: Principal Investigator
  5. R21DK091071 (ADAM, ROSALYN M) Sep 6, 2011 - Apr 30, 2014
    Development of Novel Tools for Gene Targeting in Smooth Muscle
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Thaker H, Zhang J, Miyashita SI, Cristofaro V, Park S, Hashemi Gheinani A, Sullivan MP, Adam RM, Dong M. Knockin mouse models demonstrate differential contributions of synaptotagmin-1 and -2 as receptors for botulinum neurotoxins. PLoS Pathog. 2021 Oct; 17(10):e1009994. PMID: 34662366.
    Citations:    Fields:    
  2. Vitko D, McQuaid JW, Gheinani AH, Hasegawa K, DiMartino S, Davis KH, Chung CY, Petrosino JF, Adam RM, Mansbach JM, Lee RS. Urinary Tract Infections in Children with Vesicoureteral Reflux Are Accompanied by Alterations in Urinary Microbiota and Metabolome Profiles. Eur Urol. 2021 Sep 17. PMID: 34538688.
    Citations:    Fields:    
  3. Wang Z, Cheng Z, Cristofaro V, Li J, Xiao X, Gomez P, Ge R, Gong E, Strle K, Sullivan MP, Adam RM, White MF, Olumi AF. Erratum. Inhibition of TNF-a Improves the Bladder Dysfunction That Is Associated With Type 2 Diabetes. Diabetes 2012;61:2134-2145. Diabetes. 2021 Jun; 70(6):1416. PMID: 33980694.
    Citations:    Fields:    
  4. Gundogdu G, Tosun M, Morhardt D, Gheinani AH, Algarrahi K, Yang X, Costa K, Alegria CG, Adam RM, Yang W, Mauney JR. Molecular mechanisms of esophageal epithelial regeneration following repair of surgical defects with acellular silk fibroin grafts. Sci Rep. 2021 03 29; 11(1):7086. PMID: 33782465.
    Citations:    Fields:    
  5. Atta H, Gheinani AH, Wacker A, Heshmati Y, Bigger-Allen A, Lambrinos G, Gao Y, Bielenberg DR, Adam RM. A Single Cell Dissociation Approach for Molecular Analysis of Urinary Bladder in the Mouse Following Spinal Cord Injury. J Vis Exp. 2020 06 17; (160). PMID: 32628176.
    Citations:    Fields:    Translation:AnimalsCells
  6. Jin B, Prins GS, Adam R, Yu J, Sfanos KS, Li B, Hu CD, Dong Y, You Z. Novel discoveries in urology: big data to microbiome - highlights of the society for basic urologic research 2019 annual meeting. Am J Clin Exp Urol. 2020; 8(2):73-75. PMID: 32420411.
  7. Hashemi Gheinani A, Bigger-Allen A, Wacker A, Adam RM. Systems analysis of benign bladder disorders: insights from omics analysis. Am J Physiol Renal Physiol. 2020 04 01; 318(4):F901-F910. PMID: 32116016.
    Citations:    Fields:    Translation:HumansAnimalsCells
  8. Li X, Gheinani AH, Adam RM. A multi-omics approach to understanding the field effect in bladder cancer. Transl Androl Urol. 2019 Dec; 8(6):775-778. PMID: 32038978.
  9. Allard MA, Nishioka Y, Beghdadi N, Imai K, Gelli M, Yamashita S, Kitano Y, Kokudo T, Yamashita YI, Sa Cunha A, Vibert E, Elias D, Cherqui D, Goere D, Adam R, Baba H, Hasegawa K. Multicentre study of perioperative versus adjuvant chemotherapy for resectable colorectal liver metastases. BJS Open. 2019 10; 3(5):678-686. PMID: 31592094.
    Citations: 5     Translation:Humans
  10. Hong AL, Guerriero JL, Doshi MB, Kynnap BD, Kim WJ, Schinzel AC, Modiste R, Schlauch AJ, Adam RM, Kwiatkowski DJ, Beroukhim R, Letai A, Rosenberg JE, Hahn WC. MCL1 and DEDD Promote Urothelial Carcinoma Progression. Mol Cancer Res. 2019 06; 17(6):1294-1304. PMID: 30777879.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  11. Gheinani AH, Köck I, Vasquez E, Baumgartner U, Bigger-Allen A, Sack BS, Burkhard FC, Adam RM, Monastyrskaya K. Concordant miRNA and mRNA expression profiles in humans and mice with bladder outlet obstruction. Am J Clin Exp Urol. 2018; 6(6):219-233. PMID: 30697578.
  12. Tian S, Muneeruddin K, Choi MY, Tao L, Bhuiyan RH, Ohmi Y, Furukawa K, Furukawa K, Boland S, Shaffer SA, Adam RM, Dong M. Genome-wide CRISPR screens for Shiga toxins and ricin reveal Golgi proteins critical for glycosylation. PLoS Biol. 2018 11; 16(11):e2006951. PMID: 30481169.
    Citations: 24     Fields:    Translation:HumansCells
  13. Ingersoll MA, Li X, Inman BA, Greiner JW, Black PC, Adam RM. Immunology, Immunotherapy, and Translating Basic Science into the Clinic for Bladder Cancer. Bladder Cancer. 2018 Oct 29; 4(4):429-440. PMID: 30417054.
    Citations: 1     
  14. Doyle C, Cristofaro V, Sullivan MP, Adam RM. Inosine - a Multifunctional Treatment for Complications of Neurologic Injury. Cell Physiol Biochem. 2018; 49(6):2293-2303. PMID: 30261493.
    Citations: 4     Fields:    Translation:Humans
  15. Dao DT, Anez-Bustillos L, Adam RM, Puder M, Bielenberg DR. Heparin-Binding Epidermal Growth Factor-Like Growth Factor as a Critical Mediator of Tissue Repair and Regeneration. Am J Pathol. 2018 11; 188(11):2446-2456. PMID: 30142332.
    Citations: 15     Fields:    Translation:HumansAnimalsCells
  16. Doyle C, Cristofaro V, Sack BS, Mahmood F, Sullivan MP, Adam RM. The role of the mucosa in modulation of evoked responses in the spinal cord injured rat bladder. Neurourol Urodyn. 2018 06; 37(5):1583-1593. PMID: 29427331.
    Citations: 1     Fields:    Translation:AnimalsCells
  17. Schäfer FM, Algarrahi K, Savarino A, Yang X, Seager C, Franck D, Costa K, Liu S, Logvinenko T, Adam R, Mauney JR. Mode of Surgical Injury Influences the Source of Urothelial Progenitors during Bladder Defect Repair. Stem Cell Reports. 2017 12 12; 9(6):2005-2017. PMID: 29173895.
    Citations: 10     Fields:    Translation:HumansAnimals
  18. Speer RM, The T, Xie H, Liou L, Adam RM, Wise JP. The Cytotoxicity and Genotoxicity of Particulate and Soluble Cobalt in Human Urothelial Cells. Biol Trace Elem Res. 2017 Nov; 180(1):48-55. PMID: 28324276.
    Citations: 1     Fields:    Translation:HumansCells
  19. Doyle C, Cristofaro V, Sack BS, Lukianov SN, Schäfer M, Chung YG, Sullivan MP, Adam RM. Inosine attenuates spontaneous activity in the rat neurogenic bladder through an A2B pathway. Sci Rep. 2017 03 15; 7:44416. PMID: 28294142.
    Citations: 5     Fields:    Translation:HumansAnimals
  20. Minciacchi VR, Spinelli C, Reis-Sobreiro M, Cavallini L, You S, Zandian M, Li X, Mishra R, Chiarugi P, Adam RM, Posadas EM, Viglietto G, Freeman MR, Cocucci E, Bhowmick NA, Di Vizio D. MYC Mediates Large Oncosome-Induced Fibroblast Reprogramming in Prostate Cancer. Cancer Res. 2017 05 01; 77(9):2306-2317. PMID: 28202510.
    Citations: 56     Fields:    Translation:HumansAnimalsCells
  21. Vasquez E, Cristofaro V, Lukianov S, Burkhard FC, Gheinani AH, Monastyrskaya K, Bielenberg DR, Sullivan MP, Adam RM. Deletion of neuropilin 2 enhances detrusor contractility following bladder outlet obstruction. JCI Insight. 2017 02 09; 2(3):e90617. PMID: 28194441.
    Citations: 4     Fields:    Translation:HumansAnimals
  22. Mucka P, Levonyak N, Geretti E, Zwaans BMM, Li X, Adini I, Klagsbrun M, Adam RM, Bielenberg DR. Inflammation and Lymphedema Are Exacerbated and Prolonged by Neuropilin 2 Deficiency. Am J Pathol. 2016 11; 186(11):2803-2812. PMID: 27751443.
    Citations: 9     Fields:    Translation:HumansAnimals
  23. Wise SS, Holmes AL, Liou L, Adam RM, Wise JP. Hexavalent chromium induces chromosome instability in human urothelial cells. Toxicol Appl Pharmacol. 2016 Apr 01; 296:54-60. PMID: 26908176.
    Citations: 5     Fields:    Translation:HumansCells
  24. Chung YG, Seth A, Doyle C, Franck D, Kim D, Cristofaro V, Benowitz LI, Tu DD, Estrada CR, Mauney JR, Sullivan MP, Adam RM. Inosine Improves Neurogenic Detrusor Overactivity following Spinal Cord Injury. PLoS One. 2015; 10(11):e0141492. PMID: 26529505.
    Citations: 5     Fields:    Translation:Animals
  25. Adam RM, DeGraff DJ. Molecular mechanisms of squamous differentiation in urothelial cell carcinoma: a paradigm for molecular subtyping of urothelial cell carcinoma of the bladder. Urol Oncol. 2015 Oct; 33(10):444-50. PMID: 26254697.
    Citations: 3     Fields:    Translation:HumansCells
  26. Vivante A, Kleppa MJ, Schulz J, Kohl S, Sharma A, Sharma A, Chen J, Shril S, Hwang DY, Weiss AC, Kaminski MM, Shukrun R, Kemper MJ, Lehnhardt A, Beetz R, Sanna-Cherchi S, Verbitsky M, Gharavi AG, Stuart HM, Feather SA, Goodship JA, Goodship TH, Woolf AS, Westra SJ, Doody DP, Bauer SB, Lee RS, Adam RM, Lu W, Reutter HM, Kehinde EO, Mancini EJ, Lifton RP, Tasic V, Lienkamp SS, Jüppner H, Kispert A, Hildebrandt F. Mutations in TBX18 Cause Dominant Urinary Tract Malformations via Transcriptional Dysregulation of Ureter Development. Am J Hum Genet. 2015 Aug 06; 97(2):291-301. PMID: 26235987.
    Citations: 26     Fields:    Translation:HumansCells
  27. Morley S, You S, Pollan S, Choi J, Zhou B, Hager MH, Steadman K, Spinelli C, Rajendran K, Gertych A, Kim J, Adam RM, Yang W, Krishnan R, Knudsen BS, Di Vizio D, Freeman MR. Regulation of microtubule dynamics by DIAPH3 influences amoeboid tumor cell mechanics and sensitivity to taxanes. Sci Rep. 2015 Jul 16; 5:12136. PMID: 26179371.
    Citations: 19     Fields:    Translation:HumansCells
  28. Preis L, Herlemann A, Adam RM, Dietz HG, Kappler R, Stehr M. Platelet Derived Growth Factor Has a Role in Pressure Induced Bladder Smooth Muscle Cell Hyperplasia and Acts in a Paracrine Way. J Urol. 2015 Dec; 194(6):1797-805. PMID: 26055827.
    Citations: 3     Fields:    Translation:HumansCells
  29. Mauney JR, Adam RM. Dynamic reciprocity in cell-scaffold interactions. Adv Drug Deliv Rev. 2015 Mar; 82-83:77-85. PMID: 25453262.
    Citations: 7     Fields:    Translation:Humans
  30. Tyagi P, Smith PP, Kuchel GA, de Groat WC, Birder LA, Chermansky CJ, Adam RM, Tse V, Chancellor MB, Yoshimura N. Pathophysiology and animal modeling of underactive bladder. Int Urol Nephrol. 2014 Sep; 46 Suppl 1:S11-21. PMID: 25238890.
    Citations: 16     Fields:    Translation:Animals
  31. Lin-Tsai O, Taylor JA, Clark PE, Adam RM, Wu XR, DeGraff DJ. Progress made in the use of animal models for the study of high-risk, nonmuscle invasive bladder cancer. Curr Opin Urol. 2014 Sep; 24(5):512-6. PMID: 24921908.
    Citations: 2     Fields:    Translation:AnimalsCells
  32. Yang W, Ramachandran A, You S, Jeong H, Morley S, Mulone MD, Logvinenko T, Kim J, Hwang D, Freeman MR, Adam RM. Integration of proteomic and transcriptomic profiles identifies a novel PDGF-MYC network in human smooth muscle cells. Cell Commun Signal. 2014 Aug 01; 12:44. PMID: 25080971.
    Citations: 8     Fields:    Translation:HumansCells
  33. Chung YG, Algarrahi K, Franck D, Tu DD, Adam RM, Kaplan DL, Estrada CR, Mauney JR. The use of bi-layer silk fibroin scaffolds and small intestinal submucosa matrices to support bladder tissue regeneration in a rat model of spinal cord injury. Biomaterials. 2014 Aug; 35(26):7452-9. PMID: 24917031.
    Citations: 19     Fields:    Translation:Animals
  34. Chung YG, Tu D, Franck D, Gil ES, Algarrahi K, Adam RM, Kaplan DL, Estrada CR, Mauney JR. Acellular bi-layer silk fibroin scaffolds support tissue regeneration in a rabbit model of onlay urethroplasty. PLoS One. 2014; 9(3):e91592. PMID: 24632740.
    Citations: 16     Fields:    Translation:Animals
  35. Gandhi D, Molotkov A, Batourina E, Schneider K, Dan H, Reiley M, Laufer E, Metzger D, Liang F, Liao Y, Sun TT, Aronow B, Rosen R, Mauney J, Adam R, Rosselot C, Van Batavia J, McMahon A, McMahon J, Guo JJ, Mendelsohn C. Retinoid signaling in progenitors controls specification and regeneration of the urothelium. Dev Cell. 2013 Sep 16; 26(5):469-482. PMID: 23993789.
    Citations: 62     Fields:    Translation:HumansAnimalsCells
  36. Tu DD, Chung YG, Gil ES, Seth A, Franck D, Cristofaro V, Sullivan MP, Di Vizio D, Gomez P, Adam RM, Kaplan DL, Estrada CR, Mauney JR. Bladder tissue regeneration using acellular bi-layer silk scaffolds in a large animal model of augmentation cystoplasty. Biomaterials. 2013 Nov; 34(34):8681-9. PMID: 23953839.
    Citations: 23     Fields:    Translation:Animals
  37. Mukhopadhyay NK, Kim J, You S, Morello M, Hager MH, Huang WC, Ramachandran A, Yang J, Cinar B, Rubin MA, Adam RM, Oesterreich S, Di Vizio D, Freeman MR. Scaffold attachment factor B1 regulates the androgen receptor in concert with the growth inhibitory kinase MST1 and the methyltransferase EZH2. Oncogene. 2014 Jun 19; 33(25):3235-45. PMID: 23893242.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  38. Allard MA, Adam R, Ruiz A, Vibert E, Paule B, Levi F, Sebagh M, Guettier C, Azoulay D, Castaing D. Is unexpected peritoneal carcinomatosis still a contraindication for resection of colorectal liver metastases? Combined resection of colorectal liver metastases with peritoneal deposits discovered intra-operatively. Eur J Surg Oncol. 2013 Sep; 39(9):981-7. PMID: 23845705.
    Citations: 9     Fields:    Translation:Humans
  39. Ayala G, Morello M, Frolov A, You S, Li R, Rosati F, Bartolucci G, Danza G, Adam RM, Thompson TC, Lisanti MP, Freeman MR, Vizio DD. Loss of caveolin-1 in prostate cancer stroma correlates with reduced relapse-free survival and is functionally relevant to tumour progression. J Pathol. 2013 Sep; 231(1):77-87. PMID: 23729330.
    Citations: 47     Fields:    Translation:HumansCells
  40. Majumdar S, Gong EM, Di Vizio D, Dreyfuss J, Degraff DJ, Hager MH, Park PJ, Bellmunt J, Matusik RJ, Rosenberg JE, Adam RM. Loss of Sh3gl2/endophilin A1 is a common event in urothelial carcinoma that promotes malignant behavior. Neoplasia. 2013 Jul; 15(7):749-60. PMID: 23814487.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  41. Seth A, Chung YG, Kim D, Ramachandran A, Cristofaro V, Gomez P, Tu D, Huang L, Benowitz LI, Di Vizio D, Sullivan MP, Adam RM. The impact of discrete modes of spinal cord injury on bladder muscle contractility. BMC Urol. 2013 May 13; 13:24. PMID: 23668225.
    Citations: 8     Fields:    Translation:HumansAnimals
  42. Seth A, Chung YG, Gil ES, Tu D, Franck D, Di Vizio D, Adam RM, Kaplan DL, Estrada CR, Mauney JR. The performance of silk scaffolds in a rat model of augmentation cystoplasty. Biomaterials. 2013 Jul; 34(20):4758-65. PMID: 23545287.
    Citations: 22     Fields:    Translation:Animals
  43. Franck D, Gil ES, Adam RM, Kaplan DL, Chung YG, Estrada CR, Mauney JR. Evaluation of silk biomaterials in combination with extracellular matrix coatings for bladder tissue engineering with primary and pluripotent cells. PLoS One. 2013; 8(2):e56237. PMID: 23409160.
    Citations: 15     Fields:    Translation:HumansAnimalsCells
  44. Ramachandran A, Gangopadhyay SS, Krishnan R, Ranpura SA, Rajendran K, Ram-Mohan S, Mulone M, Gong EM, Adam RM. JunB mediates basal- and TGFß1-induced smooth muscle cell contractility. PLoS One. 2013; 8(1):e53430. PMID: 23308222.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  45. Di Vizio D, Morello M, Dudley AC, Schow PW, Adam RM, Morley S, Mulholland D, Rotinen M, Hager MH, Insabato L, Moses MA, Demichelis F, Lisanti MP, Wu H, Klagsbrun M, Bhowmick NA, Rubin MA, D'Souza-Schorey C, Freeman MR. Large oncosomes in human prostate cancer tissues and in the circulation of mice with metastatic disease. Am J Pathol. 2012 Nov; 181(5):1573-84. PMID: 23022210.
    Citations: 148     Fields:    Translation:HumansAnimalsCells
  46. Wang Z, Cheng Z, Cristofaro V, Li J, Xiao X, Gomez P, Ge R, Gong E, Strle K, Sullivan MP, Adam RM, White MF, Olumi AF. Inhibition of TNF-a improves the bladder dysfunction that is associated with type 2 diabetes. Diabetes. 2012 Aug; 61(8):2134-45. PMID: 22688336.
    Citations: 22     Fields:    Translation:AnimalsCells
  47. Bielenberg DR, Seth A, Shimizu A, Pelton K, Cristofaro V, Ramachandran A, Zwaans BM, Chen C, Krishnan R, Seth M, Huang L, Takashima S, Klagsbrun M, Sullivan MP, Adam RM. Increased smooth muscle contractility in mice deficient for neuropilin 2. Am J Pathol. 2012 Aug; 181(2):548-59. PMID: 22688055.
    Citations: 13     Fields:    Translation:HumansAnimalsCells
  48. Hager MH, Morley S, Bielenberg DR, Gao S, Morello M, Holcomb IN, Liu W, Mouneimne G, Demichelis F, Kim J, Solomon KR, Adam RM, Isaacs WB, Higgs HN, Vessella RL, Di Vizio D, Freeman MR. DIAPH3 governs the cellular transition to the amoeboid tumour phenotype. EMBO Mol Med. 2012 Aug; 4(8):743-60. PMID: 22593025.
    Citations: 47     Fields:    Translation:HumansAnimalsCells
  49. Adam RM. On the (C)USP(2a) of new targets for bladder cancer therapy? . 2012 Apr 01; 11(7):1270-1. PMID: 22426418.
    Citations:    Translation:Humans
  50. Ramachandran A, Gong EM, Pelton K, Ranpura SA, Mulone M, Seth A, Gomez P, Adam RM. FosB regulates stretch-induced expression of extracellular matrix proteins in smooth muscle. Am J Pathol. 2011 Dec; 179(6):2977-89. PMID: 21996678.
    Citations: 14     Fields:    Translation:AnimalsCells
  51. DeGraff DJ, Cates JM, Mauney JR, Clark PE, Matusik RJ, Adam RM. When urothelial differentiation pathways go wrong: implications for bladder cancer development and progression. Urol Oncol. 2013 Aug; 31(6):802-11. PMID: 21924649.
    Citations: 17     Fields:    Translation:HumansCells
  52. Gomez P, Gil ES, Lovett ML, Rockwood DN, Di Vizio D, Kaplan DL, Adam RM, Estrada CR, Mauney JR. The effect of manipulation of silk scaffold fabrication parameters on matrix performance in a murine model of bladder augmentation. Biomaterials. 2011 Oct; 32(30):7562-70. PMID: 21764119.
    Citations: 20     Fields:    Translation:Animals
  53. Guo C, Sun Y, Zhou B, Adam RM, Li X, Pu WT, Morrow BE, Moon A, Li X. A Tbx1-Six1/Eya1-Fgf8 genetic pathway controls mammalian cardiovascular and craniofacial morphogenesis. J Clin Invest. 2011 Apr; 121(4):1585-95. PMID: 21364285.
    Citations: 57     Fields:    Translation:HumansAnimalsCells
  54. Kim J, Ji M, DiDonato JA, Rackley RR, Kuang M, Sadhukhan PC, Mauney JR, Keay SK, Freeman MR, Liou LS, Adam RM. An hTERT-immortalized human urothelial cell line that responds to anti-proliferative factor. In Vitro Cell Dev Biol Anim. 2011 Jan; 47(1):2-9. PMID: 21136194.
    Citations: 26     Fields:    Translation:HumansCells
  55. Mauney JR, Cannon GM, Lovett ML, Gong EM, Di Vizio D, Gomez P, Kaplan DL, Adam RM, Estrada CR. Evaluation of gel spun silk-based biomaterials in a murine model of bladder augmentation. Biomaterials. 2011 Jan; 32(3):808-18. PMID: 20951426.
    Citations: 36     Fields:    Translation:AnimalsCells
  56. Chen C, Krishnan R, Zhou E, Ramachandran A, Tambe D, Rajendran K, Adam RM, Deng L, Fredberg JJ. Fluidization and resolidification of the human bladder smooth muscle cell in response to transient stretch. PLoS One. 2010 Aug 06; 5(8):e12035. PMID: 20700509.
    Citations: 38     Fields:    Translation:HumansCells
  57. Mauney JR, Ramachandran A, Yu RN, Daley GQ, Adam RM, Estrada CR. All-trans retinoic acid directs urothelial specification of murine embryonic stem cells via GATA4/6 signaling mechanisms. PLoS One. 2010 Jul 13; 5(7):e11513. PMID: 20644631.
    Citations: 28     Fields:    Translation:AnimalsCells
  58. Adam RM. Histone deacetylase inhibitors and bladder cancer. J Urol. 2010 Jun; 183(6):2120-1. PMID: 20399456.
    Citations:    Fields:    Translation:Humans
  59. Ramachandran A, Ranpura SA, Gong EM, Mulone M, Cannon GM, Adam RM. An Akt- and Fra-1-dependent pathway mediates platelet-derived growth factor-induced expression of thrombomodulin, a novel regulator of smooth muscle cell migration. Am J Pathol. 2010 Jul; 177(1):119-31. PMID: 20472895.
    Citations: 14     Fields:    Translation:AnimalsCells
  60. Adam R. Cell signaling in kidney cancer. J Urol. 2009 Dec; 182(6):2555-6. PMID: 19836771.
    Citations:    Fields:    Translation:HumansCells
  61. Di Vizio D, Kim J, Hager MH, Morello M, Yang W, Lafargue CJ, True LD, Rubin MA, Adam RM, Beroukhim R, Demichelis F, Freeman MR. Oncosome formation in prostate cancer: association with a region of frequent chromosomal deletion in metastatic disease. Cancer Res. 2009 Jul 01; 69(13):5601-9. PMID: 19549916.
    Citations: 160     Fields:    Translation:HumansCells
  62. Mukhopadhyay NK, Kim J, Cinar B, Ramachandran A, Hager MH, Di Vizio D, Adam RM, Rubin MA, Raychaudhuri P, De Benedetti A, Freeman MR. Heterogeneous nuclear ribonucleoprotein K is a novel regulator of androgen receptor translation. Cancer Res. 2009 Mar 15; 69(6):2210-8. PMID: 19258514.
    Citations: 25     Fields:    Translation:HumansAnimalsCells
  63. Adam RM, Yang W, Di Vizio D, Mukhopadhyay NK, Steen H. Rapid preparation of nuclei-depleted detergent-resistant membrane fractions suitable for proteomics analysis. BMC Cell Biol. 2008 Jun 05; 9:30. PMID: 18534013.
    Citations: 23     Fields:    Translation:HumansCells
  64. Di Vizio D, Adam RM, Kim J, Kim R, Sotgia F, Williams T, Demichelis F, Solomon KR, Loda M, Rubin MA, Lisanti MP, Freeman MR. Caveolin-1 interacts with a lipid raft-associated population of fatty acid synthase. . 2008 Jul 15; 7(14):2257-67. PMID: 18635971.
    Citations: 39     Translation:HumansAnimalsCells
  65. Cinar B, Fang PK, Lutchman M, Di Vizio D, Adam RM, Pavlova N, Rubin MA, Yelick PC, Freeman MR. The pro-apoptotic kinase Mst1 and its caspase cleavage products are direct inhibitors of Akt1. EMBO J. 2007 Oct 31; 26(21):4523-34. PMID: 17932490.
    Citations: 64     Fields:    Translation:HumansAnimalsCells
  66. Kanematsu A, Ramachandran A, Adam RM. GATA-6 mediates human bladder smooth muscle differentiation: involvement of a novel enhancer element in regulating alpha-smooth muscle actin gene expression. . 2007 Sep; 293(3):C1093-102. PMID: 17626241.
    Citations: 13     Translation:HumansCells
  67. Adam RM, Mukhopadhyay NK, Kim J, Di Vizio D, Cinar B, Boucher K, Solomon KR, Freeman MR. Cholesterol sensitivity of endogenous and myristoylated Akt. Cancer Res. 2007 Jul 01; 67(13):6238-46. PMID: 17616681.
    Citations: 52     Fields:    Translation:HumansCells
  68. Mukhopadhyay NK, Cinar B, Mukhopadhyay L, Lutchman M, Ferdinand AS, Kim J, Chung LW, Adam RM, Ray SK, Leiter AB, Richie JP, Liu BC, Freeman MR. The zinc finger protein ras-responsive element binding protein-1 is a coregulator of the androgen receptor: implications for the role of the Ras pathway in enhancing androgenic signaling in prostate cancer. Mol Endocrinol. 2007 Sep; 21(9):2056-70. PMID: 17550981.
    Citations: 31     Fields:    Translation:HumansCells
  69. Adam R. Cyclooxygenase-2 in transitional cell carcinoma--a legitimate target? J Urol. 2007 Mar; 177(3):818-9. PMID: 17296349.
    Citations:    Fields:    Translation:Humans
  70. Freeman MR, Cinar B, Kim J, Mukhopadhyay NK, Di Vizio D, Adam RM, Solomon KR. Transit of hormonal and EGF receptor-dependent signals through cholesterol-rich membranes. Steroids. 2007 Feb; 72(2):210-7. PMID: 17173942.
    Citations: 25     Fields:    Translation:Cells
  71. Estrada CR, Adam RM, Eaton SH, Bägli DJ, Freeman MR. Inhibition of EGFR signaling abrogates smooth muscle proliferation resulting from sustained distension of the urinary bladder. Lab Invest. 2006 Dec; 86(12):1293-302. PMID: 17043666.
    Citations: 5     Fields:    Translation:AnimalsCells
  72. Duque JL, Loughlin KR, Adam RM, Kantoff P, Mazzucchi E, Freeman MR. Measurement of plasma levels of vascular endothelial growth factor in prostate cancer patients: relationship with clinical stage, Gleason score, prostate volume, and serum prostate-specific antigen. Clinics (Sao Paulo). 2006 Oct; 61(5):401-8. PMID: 17072437.
    Citations: 16     Fields:    Translation:Humans
  73. Bouchahda M, Adam R, Giacchetti S, Li XM, Castaing D, Gholam D, Kunstlinger F, Jasmin C, Machover D, Lévi F. Effective salvage therapy of liver-only colorectal cancer metastases with chronomodulated irinotecan-fluorouracil-oxaliplatin via hepatic artery infusion. J Clin Oncol. 2006 Jun 20; 24(18_suppl):3585. PMID: 27953440.
  74. Estrada CR, Salanga M, Bielenberg DR, Harrell WB, Zurakowski D, Zhu X, Palmer MR, Freeman MR, Adam RM. Behavioral profiling of human transitional cell carcinoma ex vivo. Cancer Res. 2006 Mar 15; 66(6):3078-86. PMID: 16540657.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  75. MacLellan DL, Steen H, Adam RM, Garlick M, Zurakowski D, Gygi SP, Freeman MR, Solomon KR. A quantitative proteomic analysis of growth factor-induced compositional changes in lipid rafts of human smooth muscle cells. Proteomics. 2005 Dec; 5(18):4733-42. PMID: 16267816.
    Citations: 27     Fields:    Translation:HumansCells
  76. Nguyen HT, Hsieh MH, Gaborro A, Tinloy B, Phillips C, Adam RM. JNK/SAPK and p38 SAPK-2 mediate mechanical stretch-induced apoptosis via caspase-3 and -9 in NRK-52E renal epithelial cells. Nephron Exp Nephrol. 2006; 102(2):e49-61. PMID: 16179830.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  77. Adam RM. Recent insights into the cell biology of bladder smooth muscle. Nephron Exp Nephrol. 2006; 102(1):e1-7. PMID: 16179802.
    Citations: 5     Fields:    Translation:HumansAnimals
  78. Kim J, Adam RM, Freeman MR. Trafficking of nuclear heparin-binding epidermal growth factor-like growth factor into an epidermal growth factor receptor-dependent autocrine loop in response to oxidative stress. Cancer Res. 2005 Sep 15; 65(18):8242-9. PMID: 16166300.
    Citations: 19     Fields:    Translation:HumansCells
  79. Marcus K, Johnson M, Adam RM, O'Reilly MS, Donovan M, Atala A, Freeman MR, Soker S. Tumor cell-associated neuropilin-1 and vascular endothelial growth factor expression as determinants of tumor growth in neuroblastoma. Neuropathology. 2005 Sep; 25(3):178-87. PMID: 16193833.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  80. Bouchahda M, Tanaka K, Adam R, Giacchetti S, Brezault-Bonnet C, Li XM, Gholam D, Ghémard O, Jasmin C, Lévi F. Three-drug chronotherapy via hepatic artery as salvage treatment for patients with liver-only metastases from colorectal cancer. J Clin Oncol. 2005 Jun; 23(16_suppl):3616. PMID: 27944831.
  81. Zhuang L, Kim J, Adam RM, Solomon KR, Freeman MR. Cholesterol targeting alters lipid raft composition and cell survival in prostate cancer cells and xenografts. J Clin Invest. 2005 Apr; 115(4):959-68. PMID: 15776112.
    Citations: 190     Fields:    Translation:HumansAnimalsCells
  82. Kanematsu A, Yamamoto S, Iwai-Kanai E, Kanatani I, Imamura M, Adam RM, Tabata Y, Ogawa O. Induction of smooth muscle cell-like phenotype in marrow-derived cells among regenerating urinary bladder smooth muscle cells. Am J Pathol. 2005 Feb; 166(2):565-73. PMID: 15681839.
    Citations: 27     Fields:    Translation:AnimalsCells
  83. Kim J, Lin J, Adam RM, Lamb C, Shively SB, Freeman MR. An oxidative stress mechanism mediates chelerythrine-induced heparin-binding EGF-like growth factor ectodomain shedding. J Cell Biochem. 2005 Jan 01; 94(1):39-49. PMID: 15490481.
    Citations: 11     Fields:    Translation:AnimalsCells
  84. Orsola A, Estrada CR, Nguyen HT, Retik AB, Freeman MR, Peters CA, Adam RM. Growth and stretch response of human exstrophy bladder smooth muscle cells: molecular evidence of normal intrinsic function. BJU Int. 2005 Jan; 95(1):144-8. PMID: 15638913.
    Citations: 2     Fields:    Translation:HumansCells
  85. Stehr M, Estrada CR, Khoury J, Danciu TE, Sullivan MP, Peters CA, Solomon KR, Freeman MR, Adam RM. Caveolae are negative regulators of transforming growth factor-beta1 signaling in ureteral smooth muscle cells. J Urol. 2004 Dec; 172(6 Pt 1):2451-5. PMID: 15538289.
    Citations: 6     Fields:    Translation:AnimalsCells
  86. Adam RM, Eaton SH, Estrada C, Nimgaonkar A, Shih SC, Smith LE, Kohane IS, Bägli D, Freeman MR. Mechanical stretch is a highly selective regulator of gene expression in human bladder smooth muscle cells. Physiol Genomics. 2004 Dec 15; 20(1):36-44. PMID: 15467014.
    Citations: 34     Fields:    Translation:HumansAnimalsCells
  87. Danciu TE, Gagari E, Adam RM, Damoulis PD, Freeman MR. Mechanical strain delivers anti-apoptotic and proliferative signals to gingival fibroblasts. J Dent Res. 2004 Aug; 83(8):596-601. PMID: 15271966.
    Citations: 13     Fields:    Translation:HumansCells
  88. Adam R. Rho-kinase inhibitors: potential therapeutics for benign prostate hyperplasia. J Urol. 2003 Dec; 170(6 Pt 1):2523-4. PMID: 14634464.
    Citations: 1     Fields:    Translation:Humans
  89. Kim J, Adam RM, Solomon KR, Freeman MR. Involvement of cholesterol-rich lipid rafts in interleukin-6-induced neuroendocrine differentiation of LNCaP prostate cancer cells. Endocrinology. 2004 Feb; 145(2):613-9. PMID: 14563701.
    Citations: 23     Fields:    Translation:HumansCells
  90. Adam RM, Roth JA, Cheng HL, Rice DC, Khoury J, Bauer SB, Peters CA, Freeman MR. Signaling through PI3K/Akt mediates stretch and PDGF-BB-dependent DNA synthesis in bladder smooth muscle cells. J Urol. 2003 Jun; 169(6):2388-93. PMID: 12771803.
    Citations: 20     Fields:    Translation:AnimalsCells
  91. Stehr M, Adam RM, Khoury J, Zhuang L, Solomon KR, Peters CA, Freeman MR. Platelet derived growth factor-BB is a potent mitogen for rat ureteral and human bladder smooth muscle cells: dependence on lipid rafts for cell signaling. J Urol. 2003 Mar; 169(3):1165-70. PMID: 12576874.
    Citations: 17     Fields:    Translation:HumansAnimalsCells
  92. Danciu TE, Adam RM, Naruse K, Freeman MR, Hauschka PV. Calcium regulates the PI3K-Akt pathway in stretched osteoblasts. FEBS Lett. 2003 Feb 11; 536(1-3):193-7. PMID: 12586362.
    Citations: 46     Fields:    Translation:AnimalsCells
  93. Adam RM, Danciu T, McLellan DL, Borer JG, Lin J, Zurakowski D, Weinstein MH, Rajjayabun PH, Mellon JK, Freeman MR. A nuclear form of the heparin-binding epidermal growth factor-like growth factor precursor is a feature of aggressive transitional cell carcinoma. Cancer Res. 2003 Jan 15; 63(2):484-90. PMID: 12543806.
    Citations: 21     Fields:    Translation:HumansCells
  94. Zhuang L, Peng JB, Tou L, Takanaga H, Adam RM, Hediger MA, Freeman MR. Calcium-selective ion channel, CaT1, is apically localized in gastrointestinal tract epithelia and is aberrantly expressed in human malignancies. Lab Invest. 2002 Dec; 82(12):1755-64. PMID: 12480925.
    Citations: 69     Fields:    Translation:HumansAnimalsCells
  95. Adam RM, Kim J, Lin J, Orsola A, Zhuang L, Rice DC, Freeman MR. Heparin-binding epidermal growth factor-like growth factor stimulates androgen-independent prostate tumor growth and antagonizes androgen receptor function. Endocrinology. 2002 Dec; 143(12):4599-608. PMID: 12446587.
    Citations: 19     Fields:    Translation:AnimalsCells
  96. Orsola A, Adam RM, Peters CA, Freeman MR. The decision to undergo DNA or protein synthesis is determined by the degree of mechanical deformation in human bladder muscle cells. Urology. 2002 May; 59(5):779-83. PMID: 11992928.
    Citations: 3     Fields:    Translation:HumansCells
  97. Kim J, Adam RM, Freeman MR. Activation of the Erk mitogen-activated protein kinase pathway stimulates neuroendocrine differentiation in LNCaP cells independently of cell cycle withdrawal and STAT3 phosphorylation. Cancer Res. 2002 Mar 01; 62(5):1549-54. PMID: 11888934.
    Citations: 27     Fields:    Translation:HumansCells
  98. Adam RM, Orsola A, Freeman MR. A novel method for implantation of LNCaP prostate tumor cells under the renal capsule. In Vitro Cell Dev Biol Anim. 2001 Jun; 37(6):360-2. PMID: 11515968.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  99. Peng JB, Zhuang L, Berger UV, Adam RM, Williams BJ, Brown EM, Hediger MA, Freeman MR. CaT1 expression correlates with tumor grade in prostate cancer. Biochem Biophys Res Commun. 2001 Apr 06; 282(3):729-34. PMID: 11401523.
    Citations: 48     Fields:    Translation:HumansCells
  100. Duque JL, Adam RM, Mullen JS, Lin J, Richie JP, Freeman MR. Heparin-binding epidermal growth factor-like growth factor is an autocrine mediator of human prostate stromal cell growth in vitro. J Urol. 2001 Jan; 165(1):284-8. PMID: 11125426.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  101. Nguyen HT, Adam RM, Bride SH, Park JM, Peters CA, Freeman MR. Cyclic stretch activates p38 SAPK2-, ErbB2-, and AT1-dependent signaling in bladder smooth muscle cells. . 2000 Oct; 279(4):C1155-67. PMID: 11003596.
    Citations: 20     Translation:AnimalsCells
  102. Nguyen HT, Bride SH, Badawy AB, Adam RM, Lin J, Orsola A, Guthrie PD, Freeman MR, Peters CA. Heparin-binding EGF-like growth factor is up-regulated in the obstructed kidney in a cell- and region-specific manner and acts to inhibit apoptosis. Am J Pathol. 2000 Mar; 156(3):889-98. PMID: 10702406.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  103. Adam RM, Borer JG, Williams J, Eastham JA, Loughlin KR, Freeman MR. Amphiregulin is coordinately expressed with heparin-binding epidermal growth factor-like growth factor in the interstitial smooth muscle of the human prostate. Endocrinology. 1999 Dec; 140(12):5866-75. PMID: 10579352.
    Citations: 7     Fields:    Translation:HumansCells
  104. Adam RM, Borer JG, Williams BJ, Eastham JA, Loughlin KR, Freeman MR. Amphiregulin Is Coordinately Expressed with Heparin-Binding Epidermal Growth Factor-Like Growth Factor in the Interstitial Smooth Muscle of the Human Prostate1. Endocrinology. 1999 Dec 01; 140(12):5866-5875. PMID: 28204312.
  105. Borer JG, Park JM, Atala A, Nguyen HT, Adam RM, Retik AB, Freeman MR. Heparin-binding EGF-like growth factor expression increases selectively in bladder smooth muscle in response to lower urinary tract obstruction. Lab Invest. 1999 Nov; 79(11):1335-45. PMID: 10576204.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  106. Duque JL, Loughlin KR, Adam RM, Kantoff PW, Zurakowski D, Freeman MR. Plasma levels of vascular endothelial growth factor are increased in patients with metastatic prostate cancer. Urology. 1999 Sep; 54(3):523-7. PMID: 10475365.
    Citations: 59     Fields:    Translation:Humans
  107. Park JM, Adam RM, Peters CA, Guthrie PD, Sun Z, Klagsbrun M, Freeman MR. AP-1 mediates stretch-induced expression of HB-EGF in bladder smooth muscle cells. Am J Physiol. 1999 08; 277(2):C294-301. PMID: 10444406.
    Citations: 23     Fields:    Translation:AnimalsCells
  108. Nguyen HT, Park JM, Peters CA, Adam RM, Orsola A, Atala A, Freeman MR. Cell-specific activation of the HB-EGF and ErbB1 genes by stretch in primary human bladder cells. In Vitro Cell Dev Biol Anim. 1999 Jul-Aug; 35(7):371-5. PMID: 10462199.
    Citations: 8     Fields:    Translation:HumansCells
  109. Lin J, Adam RM, Santiestevan E, Freeman MR. The phosphatidylinositol 3'-kinase pathway is a dominant growth factor-activated cell survival pathway in LNCaP human prostate carcinoma cells. Cancer Res. 1999 Jun 15; 59(12):2891-7. PMID: 10383151.
    Citations: 56     Fields:    Translation:HumansCells
  110. Dethlefsen SM, Raab G, Moses MA, Adam RM, Klagsbrun M, Freeman MR. Extracellular calcium influx stimulates metalloproteinase cleavage and secretion of heparin-binding EGF-like growth factor independently of protein kinase C. J Cell Biochem. 1998 May 01; 69(2):143-53. PMID: 9548562.
    Citations: 34     Fields:    Translation:HumansAnimalsCells
  111. Freeman MR, Paul S, Kaefer M, Ishikawa M, Adam RM, Renshaw AA, Elenius K, Klagsbrun M. Heparin-binding EGF-like growth factor in the human prostate: synthesis predominantly by interstitial and vascular smooth muscle cells and action as a carcinoma cell mitogen. J Cell Biochem. 1998 Mar 01; 68(3):328-38. PMID: 9518259.
    Citations: 10     Fields:    Translation:HumansCells
  112. Freeman MR, Yoo JJ, Raab G, Soker S, Adam RM, Schneck FX, Renshaw AA, Klagsbrun M, Atala A. Heparin-binding EGF-like growth factor is an autocrine growth factor for human urothelial cells and is synthesized by epithelial and smooth muscle cells in the human bladder. J Clin Invest. 1997 Mar 01; 99(5):1028-36. PMID: 9062361.
    Citations: 31     Fields:    Translation:HumansCells
  113. Adam RM, Chamberlin SG, Davies DE. Induction of anchorage-independent growth by amphiregulin. Growth Factors. 1996; 13(3-4):193-203. PMID: 8919027.
    Citations:    Fields:    Translation:HumansAnimalsCells
  114. Adam R, Drummond DR, Solic N, Holt SJ, Sharma RP, Chamberlin SG, Davies DE. Modulation of the receptor binding affinity of amphiregulin by modification of its carboxyl terminal tail. Biochim Biophys Acta. 1995 Apr 06; 1266(1):83-90. PMID: 7718625.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  115. Adam R, Schmidt C, Di Paolo M, Tulusan AH. [Long-term follow-up of patients with borderline tumors of the ovaries]. Gynakol Rundsch. 1990; 30 Suppl 1:48-50. PMID: 2079299.
    Citations:    Fields:    Translation:Humans
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.