Harvard Catalyst Profiles

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Jae Keith Joung, M.D.,Ph.D.

Co-Author

This page shows the publications co-authored by Jae Joung and Benjamin Kleinstiver.
Connection Strength

5.551
  1. Publisher Correction: Engineered CRISPR-Cas12a variants with increased activities and improved targeting ranges for gene, epigenetic and base editing. Nat Biotechnol. 2020 Jul; 38(7):901.
    View in: PubMed
    Score: 0.907
  2. Engineered CRISPR-Cas12a variants with increased activities and improved targeting ranges for gene, epigenetic and base editing. Nat Biotechnol. 2019 03; 37(3):276-282.
    View in: PubMed
    Score: 0.824
  3. Genome-wide specificities of CRISPR-Cas Cpf1 nucleases in human cells. Nat Biotechnol. 2016 08; 34(8):869-74.
    View in: PubMed
    Score: 0.687
  4. High-fidelity CRISPR-Cas9 nucleases with no detectable genome-wide off-target effects. Nature. 2016 Jan 28; 529(7587):490-5.
    View in: PubMed
    Score: 0.665
  5. Broadening the targeting range of Staphylococcus aureus CRISPR-Cas9 by modifying PAM recognition. Nat Biotechnol. 2015 Dec; 33(12):1293-1298.
    View in: PubMed
    Score: 0.657
  6. Engineered CRISPR-Cas9 nucleases with altered PAM specificities. Nature. 2015 Jul 23; 523(7561):481-5.
    View in: PubMed
    Score: 0.640
  7. Scalable characterization of the PAM requirements of CRISPR-Cas enzymes using HT-PAMDA. Nat Protoc. 2021 03; 16(3):1511-1547.
    View in: PubMed
    Score: 0.236
  8. Inducible and multiplex gene regulation using CRISPR-Cpf1-based transcription factors. Nat Methods. 2017 Dec; 14(12):1163-1166.
    View in: PubMed
    Score: 0.189
  9. Cell-based artificial APC resistant to lentiviral transduction for efficient generation of CAR-T cells from various cell sources. J Immunother Cancer. 2020 09; 8(2).
    View in: PubMed
    Score: 0.057
  10. Optimization of AsCas12a for combinatorial genetic screens in human cells. Nat Biotechnol. 2021 01; 39(1):94-104.
    View in: PubMed
    Score: 0.057
  11. Mutant Allele-Specific CRISPR Disruption in DYT1 Dystonia Fibroblasts Restores Cell Function. Mol Ther Nucleic Acids. 2020 Sep 04; 21:1-12.
    View in: PubMed
    Score: 0.056
  12. High levels of AAV vector integration into CRISPR-induced DNA breaks. Nat Commun. 2019 09 30; 10(1):4439.
    View in: PubMed
    Score: 0.054
  13. Allele-specific gene editing prevents deafness in a model of dominant progressive hearing loss. Nat Med. 2019 07; 25(7):1123-1130.
    View in: PubMed
    Score: 0.053
  14. Discovery of widespread type I and type V CRISPR-Cas inhibitors. Science. 2018 10 12; 362(6411):240-242.
    View in: PubMed
    Score: 0.050
  15. Activities and specificities of CRISPR/Cas9 and Cas12a nucleases for targeted mutagenesis in maize. Plant Biotechnol J. 2019 02; 17(2):362-372.
    View in: PubMed
    Score: 0.050
  16. Temporal and Spatial Post-Transcriptional Regulation of Zebrafish tie1 mRNA by Long Noncoding RNA During Brain Vascular Assembly. Arterioscler Thromb Vasc Biol. 2018 07; 38(7):1562-1575.
    View in: PubMed
    Score: 0.049
  17. CRISPR/Cas9 Mediated Disruption of the Swedish APP Allele as a Therapeutic Approach for Early-Onset Alzheimer's Disease. Mol Ther Nucleic Acids. 2018 Jun 01; 11:429-440.
    View in: PubMed
    Score: 0.048
  18. Allele-Specific CRISPR-Cas9 Genome Editing of the Single-Base P23H Mutation for Rhodopsin-Associated Dominant Retinitis Pigmentosa. CRISPR J. 2018 02; 1:55-64.
    View in: PubMed
    Score: 0.048
  19. Prediction of off-target activities for the end-to-end design of CRISPR guide RNAs. Nat Biomed Eng. 2018 Jan; 2(1):38-47.
    View in: PubMed
    Score: 0.048
  20. Enhanced proofreading governs CRISPR-Cas9 targeting accuracy. Nature. 2017 10 19; 550(7676):407-410.
    View in: PubMed
    Score: 0.047
  21. Camptothecin resistance is determined by the regulation of topoisomerase I degradation mediated by ubiquitin proteasome pathway. Oncotarget. 2017 Jul 04; 8(27):43733-43751.
    View in: PubMed
    Score: 0.046
  22. Isocitrate Dehydrogenase Mutations Confer Dasatinib Hypersensitivity and SRC Dependence in Intrahepatic Cholangiocarcinoma. Cancer Discov. 2016 07; 6(7):727-39.
    View in: PubMed
    Score: 0.043
  23. Hypoxia drives transient site-specific copy gain and drug-resistant gene expression. Genes Dev. 2015 May 15; 29(10):1018-31.
    View in: PubMed
    Score: 0.040
Connection Strength
The connection strength for co-authors is the sum of the scores for each of their shared publications.

Publication scores are based on many factors, including how long ago they were written and whether the person is a first or senior author.
Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.