Harvard Catalyst Profiles

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Jae Keith Joung, M.D.,Ph.D.

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Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Dunbar CE, High KA, Joung JK, Kohn DB, Ozawa K, Sadelain M. Gene therapy comes of age. Science. 2018 01 12; 359(6372). PMID: 29326244.
    Citations: 10     Fields:    Translation:HumansAnimals
  2. Rogers KW, Lord ND, Gagnon JA, Pauli A, Zimmerman S, Aksel DC, Reyon D, Tsai SQ, Joung JK, Schier AF. Nodal patterning without Lefty inhibitory feedback is functional but fragile. Elife. 2017 12 07; 6. PMID: 29215332.
    Citations:    Fields:    Translation:AnimalsCells
  3. Tak YE, Kleinstiver BP, Nuñez JK, Hsu JY, Horng JE, Gong J, Weissman JS, Joung JK. Inducible and multiplex gene regulation using CRISPR-Cpf1-based transcription factors. Nat Methods. 2017 Dec; 14(12):1163-1166. PMID: 29083402.
    Citations: 7     Fields:    Translation:HumansCells
  4. Chen JS, Dagdas YS, Kleinstiver BP, Welch MM, Sousa AA, Harrington LB, Sternberg SH, Joung JK, Yildiz A, Doudna JA. Enhanced proofreading governs CRISPR-Cas9 targeting accuracy. Nature. 2017 10 19; 550(7676):407-410. PMID: 28931002.
    Citations: 44     Fields:    Translation:HumansCells
  5. Ando K, Shah AK, Sachdev V, Kleinstiver BP, Taylor-Parker J, Welch MM, Hu Y, Salgia R, White FM, Parvin JD, Ozonoff A, Rameh LE, Joung JK, Bharti AK. Camptothecin resistance is determined by the regulation of topoisomerase I degradation mediated by ubiquitin proteasome pathway. Oncotarget. 2017 Jul 04; 8(27):43733-43751. PMID: 28415827.
    Citations: 4     Fields:    Translation:HumansCells
  6. Hu Z, Liu Y, Huarng MC, Menegatti M, Reyon D, Rost MS, Norris ZG, Richter CE, Stapleton AN, Chi NC, Peyvandi F, Joung JK, Shavit JA. Genome editing of factor X in zebrafish reveals unexpected tolerance of severe defects in the common pathway. Blood. 2017 08 03; 130(5):666-676. PMID: 28576875.
    Citations: 2     Fields:    Translation:HumansAnimals
  7. Tsai SQ, Nguyen NT, Malagon-Lopez J, Topkar VV, Aryee MJ, Joung JK. CIRCLE-seq: a highly sensitive in vitro screen for genome-wide CRISPR-Cas9 nuclease off-targets. Nat Methods. 2017 Jun; 14(6):607-614. PMID: 28459458.
    Citations: 23     Fields:    Translation:Cells
  8. Kleinstiver BP, Tsai SQ, Prew MS, Nguyen NT, Welch MM, Lopez JM, McCaw ZR, Aryee MJ, Joung JK. Genome-wide specificities of CRISPR-Cas Cpf1 nucleases in human cells. Nat Biotechnol. 2016 08; 34(8):869-74. PMID: 27347757.
    Citations: 73     Fields:    Translation:HumansCells
  9. Saha SK, Gordan JD, Kleinstiver BP, Vu P, Najem MS, Yeo JC, Shi L, Kato Y, Levin RS, Webber JT, Damon LJ, Egan RK, Greninger P, McDermott U, Garnett MJ, Jenkins RL, Rieger-Christ KM, Sullivan TB, Hezel AF, Liss AS, Mizukami Y, Goyal L, Ferrone CR, Zhu AX, Joung JK, Shokat KM, Benes CH, Bardeesy N. Isocitrate Dehydrogenase Mutations Confer Dasatinib Hypersensitivity and SRC Dependence in Intrahepatic Cholangiocarcinoma. Cancer Discov. 2016 07; 6(7):727-39. PMID: 27231123.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
  10. Tsai SQ, Topkar VV, Joung JK, Aryee MJ. Open-source guideseq software for analysis of GUIDE-seq data. Nat Biotechnol. 2016 05 06; 34(5):483. PMID: 27153277.
    Citations: 7     Fields:    Translation:Cells
  11. Tsai SQ, Joung JK. Defining and improving the genome-wide specificities of CRISPR-Cas9 nucleases. Nat Rev Genet. 2016 May; 17(5):300-12. PMID: 27087594.
    Citations: 57     Fields:    Translation:Humans
  12. Kleinstiver BP, Pattanayak V, Prew MS, Tsai SQ, Nguyen NT, Zheng Z, Joung JK. High-fidelity CRISPR-Cas9 nucleases with no detectable genome-wide off-target effects. Nature. 2016 Jan 28; 529(7587):490-5. PMID: 26735016.
    Citations: 318     Fields:    Translation:HumansCells
  13. Joung JK, Voytas DF, Kamens J. Accelerating research through reagent repositories: the genome editing example. Genome Biol. 2015 Nov 20; 16:255. PMID: 26585970.
    Citations: 2     Fields:    
  14. Kleinstiver BP, Prew MS, Tsai SQ, Nguyen NT, Topkar VV, Zheng Z, Joung JK. Broadening the targeting range of Staphylococcus aureus CRISPR-Cas9 by modifying PAM recognition. Nat Biotechnol. 2015 Dec; 33(12):1293-1298. PMID: 26524662.
    Citations: 89     Fields:    
  15. Wyvekens N, Tsai SQ, Joung JK. Genome Editing in Human Cells Using CRISPR/Cas Nucleases. Curr Protoc Mol Biol. 2015 Oct 01; 112:31.3.1-18. PMID: 26423589.
    Citations: 5     Fields:    Translation:HumansCells
  16. Spisák S, Lawrenson K, Fu Y, Csabai I, Cottman RT, Seo JH, Haiman C, Han Y, Lenci R, Li Q, Tisza V, Szállási Z, Herbert ZT, Chabot M, Pomerantz M, Solymosi N, Gayther SA, Joung JK, Freedman ML. CAUSEL: an epigenome- and genome-editing pipeline for establishing function of noncoding GWAS variants. Nat Med. 2015 Nov; 21(11):1357-63. PMID: 26398868.
    Citations: 22     Fields:    Translation:HumansCells
  17. Hubbard BP, Badran AH, Zuris JA, Guilinger JP, Davis KM, Chen L, Tsai SQ, Sander JD, Joung JK, Liu DR. Continuous directed evolution of DNA-binding proteins to improve TALEN specificity. Nat Methods. 2015 Oct; 12(10):939-42. PMID: 26258293.
    Citations: 17     Fields:    Translation:Humans
  18. Joung JK. Unwanted mutations: Standards needed for gene-editing errors. Nature. 2015 Jul 09; 523(7559):158. PMID: 26156364.
    Citations: 2     Fields:    
  19. Wyvekens N, Topkar VV, Khayter C, Joung JK, Tsai SQ. Dimeric CRISPR RNA-Guided FokI-dCas9 Nucleases Directed by Truncated gRNAs for Highly Specific Genome Editing. Hum Gene Ther. 2015 Jul; 26(7):425-31. PMID: 26068112.
    Citations: 34     Fields:    Translation:HumansCells
  20. Kleinstiver BP, Prew MS, Tsai SQ, Topkar VV, Nguyen NT, Zheng Z, Gonzales AP, Li Z, Peterson RT, Yeh JR, Aryee MJ, Joung JK. Engineered CRISPR-Cas9 nucleases with altered PAM specificities. Nature. 2015 Jul 23; 523(7561):481-5. PMID: 26098369.
    Citations: 256     Fields:    Translation:HumansAnimalsCells
  21. Rogers JM, Barrera LA, Reyon D, Sander JD, Kellis M, Joung JK, Bulyk ML. Context influences on TALE-DNA binding revealed by quantitative profiling. Nat Commun. 2015 Jun 11; 6:7440. PMID: 26067805.
    Citations: 4     Fields:    Translation:Cells
  22. Rahman SH, Kuehle J, Reimann C, Mlambo T, Alzubi J, Maeder ML, Riedel H, Fisch P, Cantz T, Rudolph C, Mussolino C, Joung JK, Schambach A, Cathomen T. Rescue of DNA-PK Signaling and T-Cell Differentiation by Targeted Genome Editing in a prkdc Deficient iPSC Disease Model. PLoS Genet. 2015 May; 11(5):e1005239. PMID: 26000857.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  23. Black JC, Atabakhsh E, Kim J, Biette KM, Van Rechem C, Ladd B, Burrowes PD, Donado C, Mattoo H, Kleinstiver BP, Song B, Andriani G, Joung JK, Iliopoulos O, Montagna C, Pillai S, Getz G, Whetstine JR. Hypoxia drives transient site-specific copy gain and drug-resistant gene expression. Genes Dev. 2015 May 15; 29(10):1018-31. PMID: 25995187.
    Citations: 19     Fields:    Translation:HumansAnimalsCells
  24. Corrigan-Curay J, O'Reilly M, Kohn DB, Cannon PM, Bao G, Bushman FD, Carroll D, Cathomen T, Joung JK, Roth D, Sadelain M, Scharenberg AM, von Kalle C, Zhang F, Jambou R, Rosenthal E, Hassani M, Singh A, Porteus MH. Genome editing technologies: defining a path to clinic. Mol Ther. 2015 May; 23(5):796-806. PMID: 25943494.
    Citations: 22     Fields:    Translation:HumansAnimalsCells
  25. Liao J, Karnik R, Gu H, Ziller MJ, Clement K, Tsankov AM, Akopian V, Gifford CA, Donaghey J, Galonska C, Pop R, Reyon D, Tsai SQ, Mallard W, Joung JK, Rinn JL, Gnirke A, Meissner A. Targeted disruption of DNMT1, DNMT3A and DNMT3B in human embryonic stem cells. Nat Genet. 2015 May; 47(5):469-78. PMID: 25822089.
    Citations: 86     Fields:    Translation:HumansAnimalsCells
  26. Keung AJ, Joung JK, Khalil AS, Collins JJ. Chromatin regulation at the frontier of synthetic biology. Nat Rev Genet. 2015 Mar; 16(3):159-71. PMID: 25668787.
    Citations: 20     Fields:    Translation:HumansAnimalsCells
  27. Osborn MJ, Gabriel R, Webber BR, DeFeo AP, McElroy AN, Jarjour J, Starker CG, Wagner JE, Joung JK, Voytas DF, von Kalle C, Schmidt M, Blazar BR, Tolar J. Fanconi anemia gene editing by the CRISPR/Cas9 system. Hum Gene Ther. 2015 Feb; 26(2):114-26. PMID: 25545896.
    Citations: 26     Fields:    Translation:HumansCells
  28. Hwang WY, Fu Y, Reyon D, Gonzales AP, Joung JK, Yeh JR. Targeted Mutagenesis in Zebrafish Using CRISPR RNA-Guided Nucleases. Methods Mol Biol. 2015; 1311:317-34. PMID: 25981483.
    Citations: 7     Fields:    Translation:Animals
  29. Tsai SQ, Zheng Z, Nguyen NT, Liebers M, Topkar VV, Thapar V, Wyvekens N, Khayter C, Iafrate AJ, Le LP, Aryee MJ, Joung JK. GUIDE-seq enables genome-wide profiling of off-target cleavage by CRISPR-Cas nucleases. Nat Biotechnol. 2015 Feb; 33(2):187-197. PMID: 25513782.
    Citations: 310     Fields:    Translation:HumansCells
  30. Gjini E, Mansour MR, Sander JD, Moritz N, Nguyen AT, Kesarsing M, Gans E, He S, Chen S, Ko M, Kuang YY, Yang S, Zhou Y, Rodig S, Zon LI, Joung JK, Rao A, Look AT. A zebrafish model of myelodysplastic syndrome produced through tet2 genomic editing. Mol Cell Biol. 2015 Mar; 35(5):789-804. PMID: 25512612.
    Citations: 15     Fields:    Translation:HumansAnimalsCells
  31. Zuris JA, Thompson DB, Shu Y, Guilinger JP, Bessen JL, Hu JH, Maeder ML, Joung JK, Chen ZY, Liu DR. Cationic lipid-mediated delivery of proteins enables efficient protein-based genome editing in vitro and in vivo. Nat Biotechnol. 2015 Jan; 33(1):73-80. PMID: 25357182.
    Citations: 185     Fields:    
  32. Tsai SQ, Iafrate AJ, Joung JK. Genome editing: a tool for research and therapy: towards a functional understanding of variants for molecular diagnostics using genome editing. Nat Med. 2014 Oct; 20(10):1103-4. PMID: 25295940.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  33. Hill SJ, Rolland T, Adelmant G, Xia X, Owen MS, Dricot A, Zack TI, Sahni N, Jacob Y, Hao T, McKinney KM, Clark AP, Reyon D, Tsai SQ, Joung JK, Beroukhim R, Marto JA, Vidal M, Gaudet S, Hill DE, Livingston DM. Systematic screening reveals a role for BRCA1 in the response to transcription-associated DNA damage. Genes Dev. 2014 Sep 01; 28(17):1957-75. PMID: 25184681.
    Citations: 21     Fields:    Translation:HumansCells
  34. Kai X, Chellappa V, Donado C, Reyon D, Sekigami Y, Ataca D, Louissaint A, Mattoo H, Joung JK, Pillai S. I?B kinase ß (IKBKB) mutations in lymphomas that constitutively activate canonical nuclear factor ?B (NF?B) signaling. J Biol Chem. 2014 Sep 26; 289(39):26960-72. PMID: 25107905.
    Citations: 4     Fields:    Translation:HumansCells
  35. Tsai SQ, Joung JK. What's changed with genome editing? Cell Stem Cell. 2014 Jul 03; 15(1):3-4. PMID: 24996161.
    Citations: 10     Fields:    Translation:HumansCells
  36. Liu Y, Kretz CA, Maeder ML, Richter CE, Tsao P, Vo AH, Huarng MC, Rode T, Hu Z, Mehra R, Olson ST, Joung JK, Shavit JA. Targeted mutagenesis of zebrafish antithrombin III triggers disseminated intravascular coagulation and thrombosis, revealing insight into function. Blood. 2014 Jul 03; 124(1):142-50. PMID: 24782510.
    Citations: 13     Fields:    Translation:HumansAnimals
  37. Tsai SQ, Wyvekens N, Khayter C, Foden JA, Thapar V, Reyon D, Goodwin MJ, Aryee MJ, Joung JK. Dimeric CRISPR RNA-guided FokI nucleases for highly specific genome editing. Nat Biotechnol. 2014 Jun; 32(6):569-76. PMID: 24770325.
    Citations: 245     Fields:    Translation:HumansCells
  38. Kiskinis E, Sandoe J, Williams LA, Boulting GL, Moccia R, Wainger BJ, Han S, Peng T, Thams S, Mikkilineni S, Mellin C, Merkle FT, Davis-Dusenbery BN, Ziller M, Oakley D, Ichida J, Di Costanzo S, Atwater N, Maeder ML, Goodwin MJ, Nemesh J, Handsaker RE, Paull D, Noggle S, McCarroll SA, Joung JK, Woolf CJ, Brown RH, Eggan K. Pathways disrupted in human ALS motor neurons identified through genetic correction of mutant SOD1. Cell Stem Cell. 2014 Jun 05; 14(6):781-95. PMID: 24704492.
    Citations: 105     Fields:    Translation:HumansCells
  39. Sander JD, Joung JK. CRISPR-Cas systems for editing, regulating and targeting genomes. Nat Biotechnol. 2014 Apr; 32(4):347-55. PMID: 24584096.
    Citations: 613     Fields:    Translation:HumansAnimalsCells
  40. Guilinger JP, Pattanayak V, Reyon D, Tsai SQ, Sander JD, Joung JK, Liu DR. Broad specificity profiling of TALENs results in engineered nucleases with improved DNA-cleavage specificity. Nat Methods. 2014 Apr; 11(4):429-35. PMID: 24531420.
    Citations: 60     Fields:    Translation:HumansCells
  41. Gupta A, Christensen RG, Bell HA, Goodwin M, Patel RY, Pandey M, Enuameh MS, Rayla AL, Zhu C, Thibodeau-Beganny S, Brodsky MH, Joung JK, Wolfe SA, Stormo GD. An improved predictive recognition model for Cys(2)-His(2) zinc finger proteins. Nucleic Acids Res. 2014 Apr; 42(8):4800-12. PMID: 24523353.
    Citations: 21     Fields:    Translation:Cells
  42. Fu Y, Sander JD, Reyon D, Cascio VM, Joung JK. Improving CRISPR-Cas nuclease specificity using truncated guide RNAs. Nat Biotechnol. 2014 Mar; 32(3):279-284. PMID: 24463574.
    Citations: 428     Fields:    Translation:HumansCells
  43. Low BE, Krebs MP, Joung JK, Tsai SQ, Nishina PM, Wiles MV. Correction of the Crb1rd8 allele and retinal phenotype in C57BL/6N mice via TALEN-mediated homology-directed repair. Invest Ophthalmol Vis Sci. 2014 Jan 20; 55(1):387-95. PMID: 24346171.
    Citations: 18     Fields:    Translation:AnimalsCells
  44. Pauli A, Norris ML, Valen E, Chew GL, Gagnon JA, Zimmerman S, Mitchell A, Ma J, Dubrulle J, Reyon D, Tsai SQ, Joung JK, Saghatelian A, Schier AF. Toddler: an embryonic signal that promotes cell movement via Apelin receptors. Science. 2014 Feb 14; 343(6172):1248636. PMID: 24407481.
    Citations: 98     Fields:    Translation:AnimalsCells
  45. Fu Y, Reyon D, Joung JK. Targeted genome editing in human cells using CRISPR/Cas nucleases and truncated guide RNAs. Methods Enzymol. 2014; 546:21-45. PMID: 25398334.
    Citations: 13     Fields:    Translation:HumansCells
  46. Kieffer-Kwon KR, Tang Z, Mathe E, Qian J, Sung MH, Li G, Resch W, Baek S, Pruett N, Grøntved L, Vian L, Nelson S, Zare H, Hakim O, Reyon D, Yamane A, Nakahashi H, Kovalchuk AL, Zou J, Joung JK, Sartorelli V, Wei CL, Ruan X, Hager GL, Ruan Y, Casellas R. Interactome maps of mouse gene regulatory domains reveal basic principles of transcriptional regulation. Cell. 2013 Dec 19; 155(7):1507-20. PMID: 24360274.
    Citations: 114     Fields:    Translation:AnimalsCells
  47. Maeder ML, Angstman JF, Richardson ME, Linder SJ, Cascio VM, Tsai SQ, Ho QH, Sander JD, Reyon D, Bernstein BE, Costello JF, Wilkinson MF, Joung JK. Targeted DNA demethylation and activation of endogenous genes using programmable TALE-TET1 fusion proteins. Nat Biotechnol. 2013 Dec; 31(12):1137-42. PMID: 24108092.
    Citations: 145     Fields:    Translation:HumansCells
  48. Qi Y, Li X, Zhang Y, Starker CG, Baltes NJ, Zhang F, Sander JD, Reyon D, Joung JK, Voytas DF. Targeted deletion and inversion of tandemly arrayed genes in Arabidopsis thaliana using zinc finger nucleases. G3 (Bethesda). 2013 Oct 03; 3(10):1707-15. PMID: 23979943.
    Citations: 13     Fields:    Translation:AnimalsCells
  49. Mendenhall EM, Williamson KE, Reyon D, Zou JY, Ram O, Joung JK, Bernstein BE. Locus-specific editing of histone modifications at endogenous enhancers. Nat Biotechnol. 2013 Dec; 31(12):1133-6. PMID: 24013198.
    Citations: 127     Fields:    Translation:Cells
  50. Sander JD, Ramirez CL, Linder SJ, Pattanayak V, Shoresh N, Ku M, Foden JA, Reyon D, Bernstein BE, Liu DR, Joung JK. In silico abstraction of zinc finger nuclease cleavage profiles reveals an expanded landscape of off-target sites. Nucleic Acids Res. 2013 Oct; 41(19):e181. PMID: 23945932.
    Citations: 23     Fields:    Translation:HumansCells
  51. Maeder ML, Linder SJ, Cascio VM, Fu Y, Ho QH, Joung JK. CRISPR RNA-guided activation of endogenous human genes. Nat Methods. 2013 Oct; 10(10):977-9. PMID: 23892898.
    Citations: 251     Fields:    Translation:HumansCells
  52. Hwang WY, Fu Y, Reyon D, Maeder ML, Kaini P, Sander JD, Joung JK, Peterson RT, Yeh JR. Heritable and precise zebrafish genome editing using a CRISPR-Cas system. PLoS One. 2013; 8(7):e68708. PMID: 23874735.
    Citations: 116     Fields:    Translation:AnimalsCells
  53. Reyon D, Maeder ML, Khayter C, Tsai SQ, Foley JE, Sander JD, Joung JK. Engineering customized TALE nucleases (TALENs) and TALE transcription factors by fast ligation-based automatable solid-phase high-throughput (FLASH) assembly. Curr Protoc Mol Biol. 2013 Jul; Chapter 12:Unit 12.16. PMID: 23821439.
    Citations: 10     Fields:    
  54. Fu Y, Foden JA, Khayter C, Maeder ML, Reyon D, Joung JK, Sander JD. High-frequency off-target mutagenesis induced by CRISPR-Cas nucleases in human cells. Nat Biotechnol. 2013 Sep; 31(9):822-6. PMID: 23792628.
    Citations: 767     Fields:    Translation:HumansCells
  55. Li X, Burnight ER, Cooney AL, Malani N, Brady T, Sander JD, Staber J, Wheelan SJ, Joung JK, McCray PB, Bushman FD, Sinn PL, Craig NL. piggyBac transposase tools for genome engineering. Proc Natl Acad Sci U S A. 2013 Jun 18; 110(25):E2279-87. PMID: 23723351.
    Citations: 44     Fields:    Translation:HumansAnimalsCells
  56. Osborn MJ, Starker CG, McElroy AN, Webber BR, Riddle MJ, Xia L, DeFeo AP, Gabriel R, Schmidt M, von Kalle C, Carlson DF, Maeder ML, Joung JK, Wagner JE, Voytas DF, Blazar BR, Tolar J. TALEN-based gene correction for epidermolysis bullosa. Mol Ther. 2013 Jun; 21(6):1151-9. PMID: 23546300.
    Citations: 76     Fields:    Translation:HumansCells
  57. Maeder ML, Linder SJ, Reyon D, Angstman JF, Fu Y, Sander JD, Joung JK. Robust, synergistic regulation of human gene expression using TALE activators. Nat Methods. 2013 Mar; 10(3):243-5. PMID: 23396285.
    Citations: 70     Fields:    Translation:HumansCells
  58. Tremblay JP, Xiao X, Aartsma-Rus A, Barbas C, Blau HM, Bogdanove AJ, Boycott K, Braun S, Breakefield XO, Bueren JA, Buschmann M, Byrne BJ, Calos M, Cathomen T, Chamberlain J, Chuah M, Cornetta K, Davies KE, Dickson JG, Duchateau P, Flotte TR, Gaudet D, Gersbach CA, Gilbert R, Glorioso J, Herzog RW, High KA, Huang W, Huard J, Joung JK, Liu D, Liu D, Lochmüller H, Lustig L, Martens J, Massie B, Mavilio F, Mendell JR, Nathwani A, Ponder K, Porteus M, Puymirat J, Samulski J, Takeda S, Thrasher A, VandenDriessche T, Wei Y, Wilson JM, Wilton SD, Wolfe JH, Gao G. Translating the genomics revolution: the need for an international gene therapy consortium for monogenic diseases. Mol Ther. 2013 Feb; 21(2):266-8. PMID: 23369965.
    Citations: 7     Fields:    Translation:Humans
  59. Hwang WY, Fu Y, Reyon D, Maeder ML, Tsai SQ, Sander JD, Peterson RT, Yeh JR, Joung JK. Efficient genome editing in zebrafish using a CRISPR-Cas system. Nat Biotechnol. 2013 Mar; 31(3):227-9. PMID: 23360964.
    Citations: 746     Fields:    Translation:AnimalsCells
  60. Joung JK, Sander JD. TALENs: a widely applicable technology for targeted genome editing. Nat Rev Mol Cell Biol. 2013 Jan; 14(1):49-55. PMID: 23169466.
    Citations: 316     Fields:    Translation:HumansAnimalsCells
  61. Reyon D, Khayter C, Regan MR, Joung JK, Sander JD. Engineering designer transcription activator-like effector nucleases (TALENs) by REAL or REAL-Fast assembly. Curr Protoc Mol Biol. 2012 Oct; Chapter 12:Unit 12.15. PMID: 23026907.
    Citations: 25     Fields:    Translation:HumansAnimals
  62. Hermann M, Maeder ML, Rector K, Ruiz J, Becher B, Bürki K, Khayter C, Aguzzi A, Joung JK, Buch T, Pelczar P. Evaluation of OPEN zinc finger nucleases for direct gene targeting of the ROSA26 locus in mouse embryos. PLoS One. 2012; 7(9):e41796. PMID: 22970113.
    Citations: 19     Fields:    Translation:AnimalsCells
  63. Khalil AS, Lu TK, Bashor CJ, Ramirez CL, Pyenson NC, Joung JK, Collins JJ. A synthetic biology framework for programming eukaryotic transcription functions. Cell. 2012 Aug 03; 150(3):647-58. PMID: 22863014.
    Citations: 93     Fields:    Translation:AnimalsCells
  64. Cade L, Reyon D, Hwang WY, Tsai SQ, Patel S, Khayter C, Joung JK, Sander JD, Peterson RT, Yeh JR. Highly efficient generation of heritable zebrafish gene mutations using homo- and heterodimeric TALENs. Nucleic Acids Res. 2012 Sep; 40(16):8001-10. PMID: 22684503.
    Citations: 93     Fields:    Translation:AnimalsCells
  65. Moore FE, Reyon D, Sander JD, Martinez SA, Blackburn JS, Khayter C, Ramirez CL, Joung JK, Langenau DM. Improved somatic mutagenesis in zebrafish using transcription activator-like effector nucleases (TALENs). PLoS One. 2012; 7(5):e37877. PMID: 22655075.
    Citations: 54     Fields:    Translation:AnimalsCells
  66. Reyon D, Tsai SQ, Khayter C, Foden JA, Sander JD, Joung JK. FLASH assembly of TALENs for high-throughput genome editing. Nat Biotechnol. 2012 May; 30(5):460-5. PMID: 22484455.
    Citations: 294     Fields:    Translation:HumansCells
  67. Hwang JH, Lim MC, Joung JY, Seo SS, Kang S, Seo HK, Chung J, Park SY. Urologic complications of laparoscopic radical hysterectomy and lymphadenectomy. Int Urogynecol J. 2012 Nov; 23(11):1605-11. PMID: 22531954.
    Citations: 3     Fields:    Translation:Humans
  68. Ramirez CL, Certo MT, Mussolino C, Goodwin MJ, Cradick TJ, McCaffrey AP, Cathomen T, Scharenberg AM, Joung JK. Engineered zinc finger nickases induce homology-directed repair with reduced mutagenic effects. Nucleic Acids Res. 2012 Jul; 40(12):5560-8. PMID: 22373919.
    Citations: 62     Fields:    Translation:HumansCells
  69. Sebastiano V, Maeder ML, Angstman JF, Haddad B, Khayter C, Yeo DT, Goodwin MJ, Hawkins JS, Ramirez CL, Batista LF, Artandi SE, Wernig M, Joung JK. In situ genetic correction of the sickle cell anemia mutation in human induced pluripotent stem cells using engineered zinc finger nucleases. Stem Cells. 2011 Nov; 29(11):1717-26. PMID: 21898685.
    Citations: 122     Fields:    Translation:HumansCells
  70. Sander JD, Maeder ML, Joung JK. Engineering designer nucleases with customized cleavage specificities. Curr Protoc Mol Biol. 2011 Oct; Chapter 12:Unit12.13. PMID: 21987054.
    Citations: 7     Fields:    Translation:Cells
  71. Pattanayak V, Ramirez CL, Joung JK, Liu DR. Revealing off-target cleavage specificities of zinc-finger nucleases by in vitro selection. Nat Methods. 2011 Aug 07; 8(9):765-70. PMID: 21822273.
    Citations: 168     Fields:    Translation:HumansCells
  72. Sander JD, Cade L, Khayter C, Reyon D, Peterson RT, Joung JK, Yeh JR. Targeted gene disruption in somatic zebrafish cells using engineered TALENs. Nat Biotechnol. 2011 Aug 05; 29(8):697-8. PMID: 21822241.
    Citations: 208     Fields:    Translation:Humans
  73. Rahman SH, Maeder ML, Joung JK, Cathomen T. Zinc-finger nucleases for somatic gene therapy: the next frontier. Hum Gene Ther. 2011 Aug; 22(8):925-33. PMID: 21631241.
    Citations: 26     Fields:    Translation:HumansCells
  74. Lee J, Hirsh AS, Wittner BS, Maeder ML, Singavarapu R, Lang M, Janarthanan S, McDermott U, Yajnik V, Ramaswamy S, Joung JK, Sgroi DC. Induction of stable drug resistance in human breast cancer cells using a combinatorial zinc finger transcription factor library. PLoS One. 2011; 6(7):e21112. PMID: 21818254.
    Citations: 3     Fields:    Translation:HumansCells
  75. Curtin SJ, Zhang F, Sander JD, Haun WJ, Starker C, Baltes NJ, Reyon D, Dahlborg EJ, Goodwin MJ, Coffman AP, Dobbs D, Joung JK, Voytas DF, Stupar RM. Targeted mutagenesis of duplicated genes in soybean with zinc-finger nucleases. Plant Physiol. 2011 Jun; 156(2):466-73. PMID: 21464476.
    Citations: 44     Fields:    Translation:AnimalsCells
  76. Reyon D, Kirkpatrick JR, Sander JD, Zhang F, Voytas DF, Joung JK, Dobbs D, Coffman CR. ZFNGenome: a comprehensive resource for locating zinc finger nuclease target sites in model organisms. BMC Genomics. 2011 Jan 28; 12:83. PMID: 21276248.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  77. Sander JD, Yeh JR, Peterson RT, Joung JK. Engineering zinc finger nucleases for targeted mutagenesis of zebrafish. Methods Cell Biol. 2011; 104:51-8. PMID: 21924156.
    Citations: 18     Fields:    Translation:AnimalsCells
  78. Sander JD, Dahlborg EJ, Goodwin MJ, Cade L, Zhang F, Cifuentes D, Curtin SJ, Blackburn JS, Thibodeau-Beganny S, Qi Y, Pierick CJ, Hoffman E, Maeder ML, Khayter C, Reyon D, Dobbs D, Langenau DM, Stupar RM, Giraldez AJ, Voytas DF, Peterson RT, Yeh JR, Joung JK. Selection-free zinc-finger-nuclease engineering by context-dependent assembly (CoDA). Nat Methods. 2011 Jan; 8(1):67-9. PMID: 21151135.
    Citations: 175     Fields:    Translation:AnimalsCells
  79. Sander JD, Reyon D, Maeder ML, Foley JE, Thibodeau-Beganny S, Li X, Regan MR, Dahlborg EJ, Goodwin MJ, Fu F, Voytas DF, Joung JK, Dobbs D. Predicting success of oligomerized pool engineering (OPEN) for zinc finger target site sequences. BMC Bioinformatics. 2010 Nov 02; 11:543. PMID: 21044337.
    Citations: 12     Fields:    Translation:Cells
  80. Söllü C, Pars K, Cornu TI, Thibodeau-Beganny S, Maeder ML, Joung JK, Heilbronn R, Cathomen T. Autonomous zinc-finger nuclease pairs for targeted chromosomal deletion. Nucleic Acids Res. 2010 Dec; 38(22):8269-76. PMID: 20716517.
    Citations: 47     Fields:    Translation:HumansCells
  81. Zhang F, Maeder ML, Unger-Wallace E, Hoshaw JP, Reyon D, Christian M, Li X, Pierick CJ, Dobbs D, Peterson T, Joung JK, Voytas DF. High frequency targeted mutagenesis in Arabidopsis thaliana using zinc finger nucleases. Proc Natl Acad Sci U S A. 2010 Jun 29; 107(26):12028-33. PMID: 20508152.
    Citations: 98     Fields:    Translation:AnimalsCells
  82. Sander JD, Maeder ML, Reyon D, Voytas DF, Joung JK, Dobbs D. ZiFiT (Zinc Finger Targeter): an updated zinc finger engineering tool. Nucleic Acids Res. 2010 Jul; 38(Web Server issue):W462-8. PMID: 20435679.
    Citations: 118     Fields:    Translation:Cells
  83. Lim MC, Lee BY, Lee DO, Joung JY, Kang S, Seo SS, Chung J, Park SY. Lower urinary tract injuries diagnosed after hysterectomy: seven-year experience at a cancer hospital. J Obstet Gynaecol Res. 2010 Apr; 36(2):318-25. PMID: 20492383.
    Citations: 2     Fields:    Translation:Humans
  84. Thibodeau-Beganny S, Maeder ML, Joung JK. Engineering single Cys2His2 zinc finger domains using a bacterial cell-based two-hybrid selection system. Methods Mol Biol. 2010; 649:31-50. PMID: 20680826.
    Citations: 2     Fields:    Translation:Cells
  85. Voytas DF, Joung JK. Plant science. DNA binding made easy. Science. 2009 Dec 11; 326(5959):1491-2. PMID: 20007890.
    Citations: 8     Fields:    Translation:AnimalsCells
  86. Maeder ML, Thibodeau-Beganny S, Sander JD, Voytas DF, Joung JK. Oligomerized pool engineering (OPEN): an 'open-source' protocol for making customized zinc-finger arrays. Nat Protoc. 2009; 4(10):1471-501. PMID: 19798082.
    Citations: 76     Fields:    Translation:Cells
  87. Zou J, Maeder ML, Mali P, Pruett-Miller SM, Thibodeau-Beganny S, Chou BK, Chen G, Ye Z, Park IH, Daley GQ, Porteus MH, Joung JK, Cheng L. Gene targeting of a disease-related gene in human induced pluripotent stem and embryonic stem cells. Cell Stem Cell. 2009 Jul 02; 5(1):97-110. PMID: 19540188.
    Citations: 223     Fields:    Translation:HumansCells
  88. Townsend JA, Wright DA, Winfrey RJ, Fu F, Maeder ML, Joung JK, Voytas DF. High-frequency modification of plant genes using engineered zinc-finger nucleases. Nature. 2009 May 21; 459(7245):442-5. PMID: 19404258.
    Citations: 168     Fields:    Translation:AnimalsCells
  89. Foley JE, Yeh JR, Maeder ML, Reyon D, Sander JD, Peterson RT, Joung JK. Rapid mutation of endogenous zebrafish genes using zinc finger nucleases made by Oligomerized Pool ENgineering (OPEN). PLoS One. 2009; 4(2):e4348. PMID: 19198653.
    Citations: 99     Fields:    Translation:AnimalsCells
  90. Foley JE, Maeder ML, Pearlberg J, Joung JK, Peterson RT, Yeh JR. Targeted mutagenesis in zebrafish using customized zinc-finger nucleases. Nat Protoc. 2009; 4(12):1855-67. PMID: 20010934.
    Citations: 39     Fields:    Translation:AnimalsCells
  91. Sander JD, Zaback P, Joung JK, Voytas DF, Dobbs D. An affinity-based scoring scheme for predicting DNA-binding activities of modularly assembled zinc-finger proteins. Nucleic Acids Res. 2009 Feb; 37(2):506-15. PMID: 19056825.
    Citations: 24     Fields:    Translation:Cells
  92. Fu F, Sander JD, Maeder M, Thibodeau-Beganny S, Joung JK, Dobbs D, Miller L, Voytas DF. Zinc Finger Database (ZiFDB): a repository for information on C2H2 zinc fingers and engineered zinc-finger arrays. Nucleic Acids Res. 2009 Jan; 37(Database issue):D279-83. PMID: 18812396.
    Citations: 36     Fields:    Translation:Cells
  93. Maeder ML, Thibodeau-Beganny S, Osiak A, Wright DA, Anthony RM, Eichtinger M, Jiang T, Foley JE, Winfrey RJ, Townsend JA, Unger-Wallace E, Sander JD, Müller-Lerch F, Fu F, Pearlberg J, Göbel C, Dassie JP, Pruett-Miller SM, Porteus MH, Sgroi DC, Iafrate AJ, Dobbs D, McCray PB, Cathomen T, Voytas DF, Joung JK. Rapid "open-source" engineering of customized zinc-finger nucleases for highly efficient gene modification. Mol Cell. 2008 Jul 25; 31(2):294-301. PMID: 18657511.
    Citations: 267     Fields:    Translation:HumansCells
  94. Cathomen T, Joung JK. Zinc-finger nucleases: the next generation emerges. Mol Ther. 2008 Jul; 16(7):1200-7. PMID: 18545224.
    Citations: 107     Fields:    Translation:HumansAnimalsCells
  95. Ramirez CL, Foley JE, Wright DA, Müller-Lerch F, Rahman SH, Cornu TI, Winfrey RJ, Sander JD, Fu F, Townsend JA, Cathomen T, Voytas DF, Joung JK. Unexpected failure rates for modular assembly of engineered zinc fingers. Nat Methods. 2008 May; 5(5):374-5. PMID: 18446154.
    Citations: 134     Fields:    Translation:HumansCells
  96. Pruett-Miller SM, Connelly JP, Maeder ML, Joung JK, Porteus MH. Comparison of zinc finger nucleases for use in gene targeting in mammalian cells. Mol Ther. 2008 Apr; 16(4):707-17. PMID: 18334988.
    Citations: 53     Fields:    Translation:HumansCells
  97. Cornu TI, Thibodeau-Beganny S, Guhl E, Alwin S, Eichtinger M, Joung JK, Joung JK, Cathomen T. DNA-binding specificity is a major determinant of the activity and toxicity of zinc-finger nucleases. Mol Ther. 2008 Feb; 16(2):352-8. PMID: 18026168.
    Citations: 91     Fields:    Translation:HumansCells
  98. Meng X, Thibodeau-Beganny S, Jiang T, Joung JK, Wolfe SA. Profiling the DNA-binding specificities of engineered Cys2His2 zinc finger domains using a rapid cell-based method. Nucleic Acids Res. 2007; 35(11):e81. PMID: 17537811.
    Citations: 12     Fields:    Translation:Cells
  99. Sander JD, Zaback P, Joung JK, Voytas DF, Dobbs D. Zinc Finger Targeter (ZiFiT): an engineered zinc finger/target site design tool. Nucleic Acids Res. 2007 Jul; 35(Web Server issue):W599-605. PMID: 17526515.
    Citations: 79     Fields:    Translation:HumansCells
  100. Giesecke AV, Joung JK. The bacterial two-hybrid system as a reporter system for analyzing protein-protein interactions. CSH Protoc. 2007 Mar 01; 2007:pdb.prot4672. PMID: 21357036.
    Citations: 2     
  101. Thibodeau-Beganny S, Joung JK. Engineering Cys2His2 zinc finger domains using a bacterial cell-based two-hybrid selection system. Methods Mol Biol. 2007; 408:317-34. PMID: 18314590.
    Citations: 5     Fields:    Translation:Cells
  102. Giesecke AV, Fang R, Joung JK. Synthetic protein-protein interaction domains created by shuffling Cys2His2 zinc-fingers. Mol Syst Biol. 2006; 2:2006.2011. PMID: 16732192.
    Citations: 6     Fields:    Translation:Cells
  103. Meng X, Smith RM, Giesecke AV, Joung JK, Wolfe SA. Counter-selectable marker for bacterial-based interaction trap systems. Biotechniques. 2006 Feb; 40(2):179-84. PMID: 16526407.
    Citations: 8     Fields:    Translation:Cells
  104. Wright DA, Thibodeau-Beganny S, Sander JD, Winfrey RJ, Hirsh AS, Eichtinger M, Fu F, Porteus MH, Dobbs D, Voytas DF, Joung JK. Standardized reagents and protocols for engineering zinc finger nucleases by modular assembly. Nat Protoc. 2006; 1(3):1637-52. PMID: 17406455.
    Citations: 63     Fields:    Translation:Cells
  105. Vallet-Gely I, Donovan KE, Fang R, Joung JK, Dove SL. Repression of phase-variable cup gene expression by H-NS-like proteins in Pseudomonas aeruginosa. Proc Natl Acad Sci U S A. 2005 Aug 02; 102(31):11082-7. PMID: 16043713.
    Citations: 52     Fields:    Translation:Cells
  106. Serebriiskii IG, Fang R, Latypova E, Hopkins R, Vinson C, Joung JK, Golemis EA. A combined yeast/bacteria two-hybrid system: development and evaluation. Mol Cell Proteomics. 2005 Jun; 4(6):819-26. PMID: 15781424.
    Citations: 2     Fields:    Translation:AnimalsCells
  107. Nguyen-Hackley DH, Ramm E, Taylor CM, Joung JK, Dervan PB, Pabo CO. Allosteric inhibition of zinc-finger binding in the major groove of DNA by minor-groove binding ligands. Biochemistry. 2004 Apr 06; 43(13):3880-90. PMID: 15049695.
    Citations: 10     Fields:    Translation:HumansCells
  108. Thibodeau SA, Fang R, Joung JK. High-throughput beta-galactosidase assay for bacterial cell-based reporter systems. Biotechniques. 2004 Mar; 36(3):410-5. PMID: 15038156.
    Citations: 34     Fields:    Translation:Cells
  109. Thibodeau SA, Joung JK. An improved strategy for constructing "designer" Cys2His2 zinc finger proteins. Discov Med. 2003 Dec; 3(19):32-5. PMID: 20705034.
    Citations:    Fields:    
  110. Hurt JA, Thibodeau SA, Hirsh AS, Pabo CO, Joung JK. Highly specific zinc finger proteins obtained by directed domain shuffling and cell-based selection. Proc Natl Acad Sci U S A. 2003 Oct 14; 100(21):12271-6. PMID: 14527993.
    Citations: 50     Fields:    Translation:HumansCells
  111. Joung JK. Identifying and modifying protein-DNA and protein-protein interactions using a bacterial two-hybrid selection system. J Cell Biochem Suppl. 2001; Suppl 37:53-7. PMID: 11842428.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  112. Dove SL, Joung JK, Hochschild A. Activation of prokaryotic transcription through arbitrary protein-protein contacts. Nature. 1997 Apr 10; 386(6625):627-30. PMID: 9121589.
    Citations: 96     Fields:    Translation:Cells
  113. Joung JK, Chung EH, King G, Yu C, Hirsh AS, Hochschild A. Genetic strategy for analyzing specificity of dimer formation: Escherichia coli cyclic AMP receptor protein mutant altered in its dimerization specificity. Genes Dev. 1995 Dec 01; 9(23):2986-96. PMID: 7498794.
    Citations: 10     Fields:    Translation:Cells
  114. Joung JK, Koepp DM, Hochschild A. Synergistic activation of transcription by bacteriophage lambda cI protein and E. coli cAMP receptor protein. Science. 1994 Sep 23; 265(5180):1863-6. PMID: 8091212.
    Citations: 25     Fields:    Translation:Cells
  115. Joung JK, Le LU, Hochschild A. Synergistic activation of transcription by Escherichia coli cAMP receptor protein. Proc Natl Acad Sci U S A. 1993 Apr 01; 90(7):3083-7. PMID: 7681995.
    Citations: 27     Fields:    Translation:Cells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.