Harvard Catalyst Profiles

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Jae Keith Joung, M.D.,Ph.D.

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selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Weichert-Leahey N, Shi H, Tao T, Oldridge DA, Durbin AD, Abraham BJ, Zimmerman MW, Zhu S, Wood AC, Reyon D, Joung JK, Young RA, Diskin SJ, Maris JM, Look AT. Genetic Predisposition to Neuroblastoma Results from a Regulatory Polymorphism that Promotes the Adrenergic Cell State. bioRxiv. 2023 Mar 01. PMID: 36909587; PMCID: PMC10002714.
    Citations:    
  2. Li HS, Israni DV, Gagnon KA, Gan KA, Raymond MH, Sander JD, Roybal KT, Joung JK, Wong WW, Khalil AS. Multidimensional control of therapeutic human cell function with synthetic gene circuits. Science. 2022 12 16; 378(6625):1227-1234. PMID: 36520914.
    Citations: 4     Fields:    Translation:HumansCells
  3. Grünewald J, Miller BR, Szalay RN, Cabeceiras PK, Woodilla CJ, Holtz EJB, Petri K, Joung JK. Engineered CRISPR prime editors with compact, untethered reverse transcriptases. Nat Biotechnol. 2023 Mar; 41(3):337-343. PMID: 36163548; PMCID: PMC10023297.
    Citations: 5     Fields:    
  4. Tak YE, Horng JE, Perry NT, Schultz HT, Iyer S, Yao Q, Zou LS, Aryee MJ, Pinello L, Joung JK. Author Correction: Augmenting and directing long-range CRISPR-mediated activation in human cells. Nat Methods. 2022 Jul; 19(7):899. PMID: 35761069.
    Citations:    Fields:    
  5. Tak YE, Boulay G, Lee L, Iyer S, Perry NT, Schultz HT, Garcia SP, Broye L, Horng JE, Rengarajan S, Naigles B, Volorio A, Sander JD, Gong J, Riggi N, Joung JK, Rivera MN. Genome-wide functional perturbation of human microsatellite repeats using engineered zinc finger transcription factors. Cell Genom. 2022 Apr 13; 2(4). PMID: 35967079; PMCID: PMC9374162.
    Citations: 1     
  6. Konstantinidis E, Molisak A, Perrin F, Streubel-Gallasch L, Fayad S, Kim DY, Petri K, Aryee MJ, Aguilar X, György B, Giedraitis V, Joung JK, Pattanayak V, Essand M, Erlandsson A, Berezovska O, Ingelsson M. CRISPR-Cas9 treatment partially restores amyloid-ß 42/40 in human fibroblasts with the Alzheimer's disease PSEN1 M146L mutation. Mol Ther Nucleic Acids. 2022 Jun 14; 28:450-461. PMID: 35505961; PMCID: PMC9043867.
    Citations: 1     
  7. Petri K, Zhang W, Ma J, Schmidts A, Lee H, Horng JE, Kim DY, Kurt IC, Clement K, Hsu JY, Pinello L, Maus MV, Joung JK, Yeh JJ. Author Correction: CRISPR prime editing with ribonucleoprotein complexes in zebrafish and primary human cells. Nat Biotechnol. 2022 Feb; 40(2):273. PMID: 33986547.
    Citations:    Fields:    
  8. Malinin NL, Lee G, Lazzarotto CR, Li Y, Zheng Z, Nguyen NT, Liebers M, Topkar VV, Iafrate AJ, Le LP, Aryee MJ, Joung JK, Tsai SQ. Defining genome-wide CRISPR-Cas genome-editing nuclease activity with GUIDE-seq. Nat Protoc. 2021 12; 16(12):5592-5615. PMID: 34773119; PMCID: PMC9331158.
    Citations: 4     Fields:    Translation:HumansCells
  9. Tak YE, Horng JE, Perry NT, Schultz HT, Iyer S, Yao Q, Zou LS, Aryee MJ, Pinello L, Joung JK. Augmenting and directing long-range CRISPR-mediated activation in human cells. Nat Methods. 2021 09; 18(9):1075-1081. PMID: 34354266; PMCID: PMC8446310.
    Citations: 5     Fields:    Translation:HumansCells
  10. Garrood WT, Kranjc N, Petri K, Kim DY, Guo JA, Hammond AM, Morianou I, Pattanayak V, Joung JK, Crisanti A, Simoni A. Analysis of off-target effects in CRISPR-based gene drives in the human malaria mosquito. Proc Natl Acad Sci U S A. 2021 06 01; 118(22). PMID: 34050017.
    Citations: 11     Fields:    Translation:HumansAnimalsPHPublic Health
  11. Petri K, Zhang W, Ma J, Schmidts A, Lee H, Horng JE, Kim DY, Kurt IC, Clement K, Hsu JY, Pinello L, Maus MV, Joung JK, Yeh JJ. CRISPR prime editing with ribonucleoprotein complexes in zebrafish and primary human cells. Nat Biotechnol. 2022 02; 40(2):189-193. PMID: 33927418; PMCID: PMC8553808.
    Citations: 44     Fields:    Translation:HumansAnimalsCells
  12. Hsu JY, Grünewald J, Szalay R, Shih J, Anzalone AV, Lam KC, Shen MW, Petri K, Liu DR, Joung JK, Pinello L. PrimeDesign software for rapid and simplified design of prime editing guide RNAs. Nat Commun. 2021 02 15; 12(1):1034. PMID: 33589617.
    Citations: 37     Fields:    Translation:HumansCells
  13. Annas GJ, Beisel CL, Clement K, Crisanti A, Francis S, Galardini M, Galizi R, Grünewald J, Immobile G, Khalil AS, Müller R, Pattanayak V, Petri K, Paul L, Pinello L, Simoni A, Taxiarchi C, Joung JK. A Code of Ethics for Gene Drive Research. CRISPR J. 2021 02; 4(1):19-24. PMID: 33571044.
    Citations: 5     Fields:    Translation:HumansAnimalsPHPublic Health
  14. Walton RT, Hsu JY, Joung JK, Kleinstiver BP. Scalable characterization of the PAM requirements of CRISPR-Cas enzymes using HT-PAMDA. Nat Protoc. 2021 03; 16(3):1511-1547. PMID: 33547443.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  15. Schmidts A, Marsh LC, Srivastava AA, Bouffard AA, Boroughs AC, Scarfò I, Larson RC, Bedoya F, Choi BD, Frigault MJ, Bailey SR, Leick MB, Vatsa S, Kann MC, Prew MS, Kleinstiver BP, Joung JK, Maus MV. Cell-based artificial APC resistant to lentiviral transduction for efficient generation of CAR-T cells from various cell sources. J Immunother Cancer. 2020 09; 8(2). PMID: 32900862.
    Citations: 5     Fields:    Translation:HumansCells
  16. Kurt IC, Zhou R, Iyer S, Garcia SP, Miller BR, Langner LM, Grünewald J, Joung JK. CRISPR C-to-G base editors for inducing targeted DNA transversions in human cells. Nat Biotechnol. 2021 01; 39(1):41-46. PMID: 32690971.
    Citations: 122     Fields:    Translation:HumansCells
  17. DeWeirdt PC, Sanson KR, Sangree AK, Hegde M, Hanna RE, Feeley MN, Griffith AL, Teng T, Borys SM, Strand C, Joung JK, Kleinstiver BP, Pan X, Huang A, Doench JG. Optimization of AsCas12a for combinatorial genetic screens in human cells. Nat Biotechnol. 2021 01; 39(1):94-104. PMID: 32661438.
    Citations: 40     Fields:    Translation:HumansCells
  18. Clement K, Hsu JY, Canver MC, Joung JK, Pinello L. Technologies and Computational Analysis Strategies for CRISPR Applications. Mol Cell. 2020 07 02; 79(1):11-29. PMID: 32619467.
    Citations: 7     Fields:    Translation:Humans
  19. Kleinstiver BP, Sousa AA, Walton RT, Tak YE, Hsu JY, Clement K, Welch MM, Horng JE, Malagon-Lopez J, Scarfò I, Maus MV, Pinello L, Aryee MJ, Joung JK. Publisher Correction: Engineered CRISPR-Cas12a variants with increased activities and improved targeting ranges for gene, epigenetic and base editing. Nat Biotechnol. 2020 Jul; 38(7):901. PMID: 32541959.
    Citations: 2     Fields:    
  20. Grünewald J, Zhou R, Lareau CA, Garcia SP, Iyer S, Miller BR, Langner LM, Hsu JY, Aryee MJ, Joung JK. A dual-deaminase CRISPR base editor enables concurrent adenine and cytosine editing. Nat Biotechnol. 2020 07; 38(7):861-864. PMID: 32483364.
    Citations: 64     Fields:    Translation:HumansCells
  21. Cruz L, György B, Cheah PS, Kleinstiver BP, Eimer WA, Garcia SP, Sharma N, Ozelius LJ, Bragg DC, Joung JK, Norberto de Souza O, Macedo Timmers LFS, Breakefield XO. Mutant Allele-Specific CRISPR Disruption in DYT1 Dystonia Fibroblasts Restores Cell Function. Mol Ther Nucleic Acids. 2020 Sep 04; 21:1-12. PMID: 32502938.
    Citations: 3     
  22. Zeng J, Wu Y, Ren C, Bonanno J, Shen AH, Shea D, Gehrke JM, Clement K, Luk K, Yao Q, Kim R, Wolfe SA, Manis JP, Pinello L, Joung JK, Bauer DE. Therapeutic base editing of human hematopoietic stem cells. Nat Med. 2020 04; 26(4):535-541. PMID: 32284612.
    Citations: 89     Fields:    Translation:HumansAnimalsCells
  23. Grzegorski SJ, Hu Z, Liu Y, Yu X, Ferguson AC, Madarati H, Friedmann AP, Reyon D, Kim PY, Kretz CA, Joung JK, Shavit JA. Disruption of the kringle 1 domain of prothrombin leads to late onset mortality in zebrafish. Sci Rep. 2020 03 04; 10(1):4049. PMID: 32132579.
    Citations: 4     Fields:    Translation:AnimalsCells
  24. Ma M, Ramirez AD, Wang T, Roberts RL, Harmon KE, Schoppik D, Sharma A, Kuang C, Goei SL, Gagnon JA, Zimmerman S, Tsai SQ, Reyon D, Joung JK, Aksay ERF, Schier AF, Pan YA. Zebrafish dscaml1 Deficiency Impairs Retinal Patterning and Oculomotor Function. J Neurosci. 2020 01 02; 40(1):143-158. PMID: 31685652; PMCID: PMC6939486.
    Citations: 5     Fields:    Translation:AnimalsCells
  25. Hanlon KS, Kleinstiver BP, Garcia SP, Zaborowski MP, Volak A, Spirig SE, Muller A, Sousa AA, Tsai SQ, Bengtsson NE, Lööv C, Ingelsson M, Chamberlain JS, Corey DP, Aryee MJ, Joung JK, Breakefield XO, Maguire CA, György B. High levels of AAV vector integration into CRISPR-induced DNA breaks. Nat Commun. 2019 09 30; 10(1):4439. PMID: 31570731; PMCID: PMC6769011.
    Citations: 122     Fields:    Translation:HumansAnimalsCells
  26. Grünewald J, Zhou R, Iyer S, Lareau CA, Garcia SP, Aryee MJ, Joung JK. CRISPR DNA base editors with reduced RNA off-target and self-editing activities. Nat Biotechnol. 2019 09; 37(9):1041-1048. PMID: 31477922; PMCID: PMC6730565.
    Citations: 108     Fields:    Translation:HumansAnimalsCells
  27. György B, Nist-Lund C, Pan B, Asai Y, Karavitaki KD, Kleinstiver BP, Garcia SP, Zaborowski MP, Solanes P, Spataro S, Schneider BL, Joung JK, Géléoc GSG, Holt JR, Corey DP. Allele-specific gene editing prevents deafness in a model of dominant progressive hearing loss. Nat Med. 2019 07; 25(7):1123-1130. PMID: 31270503.
    Citations: 75     Fields:    Translation:HumansAnimalsCells
  28. Grünewald J, Zhou R, Garcia SP, Iyer S, Lareau CA, Aryee MJ, Joung JK. Transcriptome-wide off-target RNA editing induced by CRISPR-guided DNA base editors. Nature. 2019 05; 569(7756):433-437. PMID: 30995674; PMCID: PMC6657343.
    Citations: 207     Fields:    Translation:HumansAnimalsCells
  29. Lander ES, Baylis F, Zhang F, Charpentier E, Berg P, Bourgain C, Friedrich B, Joung JK, Li J, Liu D, Naldini L, Nie JB, Qiu R, Schoene-Seifert B, Shao F, Terry S, Wei W, Winnacker EL. Adopt a moratorium on heritable genome editing. Nature. 2019 03; 567(7747):165-168. PMID: 30867611.
    Citations: 74     Fields:    Translation:HumansCells
  30. Clement K, Rees H, Canver MC, Gehrke JM, Farouni R, Hsu JY, Cole MA, Liu DR, Joung JK, Bauer DE, Pinello L. CRISPResso2 provides accurate and rapid genome editing sequence analysis. Nat Biotechnol. 2019 03; 37(3):224-226. PMID: 30809026.
    Citations: 328     Fields:    Translation:HumansCells
  31. Kleinstiver BP, Sousa AA, Walton RT, Tak YE, Hsu JY, Clement K, Welch MM, Horng JE, Malagon-Lopez J, Scarfò I, Maus MV, Pinello L, Aryee MJ, Joung JK. Engineered CRISPR-Cas12a variants with increased activities and improved targeting ranges for gene, epigenetic and base editing. Nat Biotechnol. 2019 03; 37(3):276-282. PMID: 30742127; PMCID: PMC6401248.
    Citations: 170     Fields:    Translation:HumansCells
  32. Hsu JY, Fulco CP, Cole MA, Canver MC, Pellin D, Sher F, Farouni R, Clement K, Guo JA, Biasco L, Orkin SH, Engreitz JM, Lander ES, Joung JK, Bauer DE, Pinello L. CRISPR-SURF: discovering regulatory elements by deconvolution of CRISPR tiling screen data. Nat Methods. 2018 12; 15(12):992-993. PMID: 30504875; PMCID: PMC6620603.
    Citations: 13     Fields:    Translation:HumansCells
  33. Lazzarotto CR, Nguyen NT, Tang X, Malagon-Lopez J, Guo JA, Aryee MJ, Joung JK, Tsai SQ. Defining CRISPR-Cas9 genome-wide nuclease activities with CIRCLE-seq. Nat Protoc. 2018 11; 13(11):2615-2642. PMID: 30341435; PMCID: PMC6512799.
    Citations: 31     Fields:    Translation:HumansCells
  34. Dastidar S, Ardui S, Singh K, Majumdar D, Nair N, Fu Y, Reyon D, Samara E, Gerli MFM, Klein AF, De Schrijver W, Tipanee J, Seneca S, Tulalamba W, Wang H, Chai YC, In't Veld P, Furling D, Tedesco FS, Vermeesch JR, Joung JK, Chuah MK, VandenDriessche T. Efficient CRISPR/Cas9-mediated editing of trinucleotide repeat expansion in myotonic dystrophy patient-derived iPS and myogenic cells. Nucleic Acids Res. 2018 09 19; 46(16):8275-8298. PMID: 29947794; PMCID: PMC6144820.
    Citations: 48     Fields:    Translation:HumansCells
  35. Akcakaya P, Bobbin ML, Guo JA, Malagon-Lopez J, Clement K, Garcia SP, Fellows MD, Porritt MJ, Firth MA, Carreras A, Baccega T, Seeliger F, Bjursell M, Tsai SQ, Nguyen NT, Nitsch R, Mayr LM, Pinello L, Bohlooly-Y M, Aryee MJ, Maresca M, Joung JK. In vivo CRISPR editing with no detectable genome-wide off-target mutations. Nature. 2018 09; 561(7723):416-419. PMID: 30209390.
    Citations: 139     Fields:    Translation:HumansAnimals
  36. Marino ND, Zhang JY, Borges AL, Sousa AA, Leon LM, Rauch BJ, Walton RT, Berry JD, Joung JK, Kleinstiver BP, Bondy-Denomy J. Discovery of widespread type I and type V CRISPR-Cas inhibitors. Science. 2018 10 12; 362(6411):240-242. PMID: 30190308; PMCID: PMC6520112.
    Citations: 89     Fields:    Translation:HumansCells
  37. Gehrke JM, Cervantes O, Clement MK, Wu Y, Zeng J, Bauer DE, Pinello L, Joung JK. An APOBEC3A-Cas9 base editor with minimized bystander and off-target activities. Nat Biotechnol. 2018 11; 36(10):977-982. PMID: 30059493; PMCID: PMC6181770.
    Citations: 157     Fields:    Translation:HumansCells
  38. Lee K, Zhang Y, Kleinstiver BP, Guo JA, Aryee MJ, Miller J, Malzahn A, Zarecor S, Lawrence-Dill CJ, Joung JK, Qi Y, Wang K. Activities and specificities of CRISPR/Cas9 and Cas12a nucleases for targeted mutagenesis in maize. Plant Biotechnol J. 2019 02; 17(2):362-372. PMID: 29972722; PMCID: PMC6320322.
    Citations: 86     Fields:    Translation:AnimalsCells
  39. Chowdhury TA, Koceja C, Eisa-Beygi S, Kleinstiver BP, Kumar SN, Lin CW, Li K, Prabhudesai S, Joung JK, Ramchandran R. Temporal and Spatial Post-Transcriptional Regulation of Zebrafish tie1 mRNA by Long Noncoding RNA During Brain Vascular Assembly. Arterioscler Thromb Vasc Biol. 2018 07; 38(7):1562-1575. PMID: 29724820.
    Citations: 13     Fields:    Translation:AnimalsCells
  40. Canver MC, Joung JK, Pinello L. Impact of Genetic Variation on CRISPR-Cas Targeting. CRISPR J. 2018 04; 1(2):159-170. PMID: 31021199; PMCID: PMC6319324.
    Citations: 5     Fields:    
  41. Lareau CA, Clement K, Hsu JY, Pattanayak V, Joung JK, Aryee MJ, Pinello L. Response to "Unexpected mutations after CRISPR-Cas9 editing in vivo". Nat Methods. 2018 04; 15(4):238-239. PMID: 29600992.
    Citations: 14     Fields:    Translation:Cells
  42. György B, Lööv C, Zaborowski MP, Takeda S, Kleinstiver BP, Commins C, Kastanenka K, Mu D, Volak A, Giedraitis V, Lannfelt L, Maguire CA, Joung JK, Hyman BT, Breakefield XO, Ingelsson M. CRISPR/Cas9 Mediated Disruption of the Swedish APP Allele as a Therapeutic Approach for Early-Onset Alzheimer's Disease. Mol Ther Nucleic Acids. 2018 Jun 01; 11:429-440. PMID: 29858078; PMCID: PMC5992788.
    Citations: 54     
  43. Li P, Kleinstiver BP, Leon MY, Prew MS, Navarro-Gomez D, Greenwald SH, Pierce EA, Joung JK, Liu Q. Allele-Specific CRISPR-Cas9 Genome Editing of the Single-Base P23H Mutation for Rhodopsin-Associated Dominant Retinitis Pigmentosa. CRISPR J. 2018 02; 1:55-64. PMID: 31021187; PMCID: PMC6319323.
    Citations: 47     Fields:    
  44. Dunbar CE, High KA, Joung JK, Kohn DB, Ozawa K, Sadelain M. Gene therapy comes of age. Science. 2018 01 12; 359(6372). PMID: 29326244.
    Citations: 325     Fields:    Translation:HumansAnimals
  45. Listgarten J, Weinstein M, Kleinstiver BP, Sousa AA, Joung JK, Crawford J, Gao K, Hoang L, Elibol M, Doench JG, Fusi N. Prediction of off-target activities for the end-to-end design of CRISPR guide RNAs. Nat Biomed Eng. 2018 Jan; 2(1):38-47. PMID: 29998038.
    Citations: 89     Fields:    
  46. Rogers KW, Lord ND, Gagnon JA, Pauli A, Zimmerman S, Aksel DC, Reyon D, Tsai SQ, Joung JK, Schier AF. Nodal patterning without Lefty inhibitory feedback is functional but fragile. Elife. 2017 12 07; 6. PMID: 29215332.
    Citations: 18     Fields:    Translation:AnimalsCells
  47. Tak YE, Kleinstiver BP, Nuñez JK, Hsu JY, Horng JE, Gong J, Weissman JS, Joung JK. Inducible and multiplex gene regulation using CRISPR-Cpf1-based transcription factors. Nat Methods. 2017 Dec; 14(12):1163-1166. PMID: 29083402; PMCID: PMC5909187.
    Citations: 77     Fields:    Translation:HumansCells
  48. Chen JS, Dagdas YS, Kleinstiver BP, Welch MM, Sousa AA, Harrington LB, Sternberg SH, Joung JK, Yildiz A, Doudna JA. Enhanced proofreading governs CRISPR-Cas9 targeting accuracy. Nature. 2017 10 19; 550(7676):407-410. PMID: 28931002; PMCID: PMC5918688.
    Citations: 440     Fields:    Translation:HumansCells
  49. Ando K, Shah AK, Sachdev V, Kleinstiver BP, Taylor-Parker J, Welch MM, Hu Y, Salgia R, White FM, Parvin JD, Ozonoff A, Rameh LE, Joung JK, Bharti AK. Camptothecin resistance is determined by the regulation of topoisomerase I degradation mediated by ubiquitin proteasome pathway. Oncotarget. 2017 Jul 04; 8(27):43733-43751. PMID: 28415827.
    Citations: 9     Fields:    Translation:HumansCells
  50. Hu Z, Liu Y, Huarng MC, Menegatti M, Reyon D, Rost MS, Norris ZG, Richter CE, Stapleton AN, Chi NC, Peyvandi F, Joung JK, Shavit JA. Genome editing of factor X in zebrafish reveals unexpected tolerance of severe defects in the common pathway. Blood. 2017 08 03; 130(5):666-676. PMID: 28576875; PMCID: PMC5542852.
    Citations: 12     Fields:    Translation:HumansAnimals
  51. Tsai SQ, Nguyen NT, Malagon-Lopez J, Topkar VV, Aryee MJ, Joung JK. CIRCLE-seq: a highly sensitive in vitro screen for genome-wide CRISPR-Cas9 nuclease off-targets. Nat Methods. 2017 Jun; 14(6):607-614. PMID: 28459458; PMCID: PMC5924695.
    Citations: 273     Fields:    Translation:Cells
  52. Kleinstiver BP, Tsai SQ, Prew MS, Nguyen NT, Welch MM, Lopez JM, McCaw ZR, Aryee MJ, Joung JK. Genome-wide specificities of CRISPR-Cas Cpf1 nucleases in human cells. Nat Biotechnol. 2016 08; 34(8):869-74. PMID: 27347757; PMCID: PMC4980201.
    Citations: 272     Fields:    Translation:HumansCells
  53. Saha SK, Gordan JD, Kleinstiver BP, Vu P, Najem MS, Yeo JC, Shi L, Kato Y, Levin RS, Webber JT, Damon LJ, Egan RK, Greninger P, McDermott U, Garnett MJ, Jenkins RL, Rieger-Christ KM, Sullivan TB, Hezel AF, Liss AS, Mizukami Y, Goyal L, Ferrone CR, Zhu AX, Joung JK, Shokat KM, Benes CH, Bardeesy N. Isocitrate Dehydrogenase Mutations Confer Dasatinib Hypersensitivity and SRC Dependence in Intrahepatic Cholangiocarcinoma. Cancer Discov. 2016 07; 6(7):727-39. PMID: 27231123.
    Citations: 71     Fields:    Translation:HumansAnimalsCells
  54. Tsai SQ, Topkar VV, Joung JK, Aryee MJ. Open-source guideseq software for analysis of GUIDE-seq data. Nat Biotechnol. 2016 05 06; 34(5):483. PMID: 27153277.
    Citations: 30     Fields:    Translation:Cells
  55. Tsai SQ, Joung JK. Defining and improving the genome-wide specificities of CRISPR-Cas9 nucleases. Nat Rev Genet. 2016 May; 17(5):300-12. PMID: 27087594; PMCID: PMC7225572.
    Citations: 195     Fields:    Translation:Humans
  56. Kleinstiver BP, Pattanayak V, Prew MS, Tsai SQ, Nguyen NT, Zheng Z, Joung JK. High-fidelity CRISPR-Cas9 nucleases with no detectable genome-wide off-target effects. Nature. 2016 Jan 28; 529(7587):490-5. PMID: 26735016.
    Citations: 1035     Fields:    Translation:HumansCells
  57. Joung JK, Voytas DF, Kamens J. Accelerating research through reagent repositories: the genome editing example. Genome Biol. 2015 Nov 20; 16:255. PMID: 26585970; PMCID: PMC4653914.
    Citations: 3     Fields:    
  58. Kleinstiver BP, Prew MS, Tsai SQ, Nguyen NT, Topkar VV, Zheng Z, Joung JK. Broadening the targeting range of Staphylococcus aureus CRISPR-Cas9 by modifying PAM recognition. Nat Biotechnol. 2015 Dec; 33(12):1293-1298. PMID: 26524662; PMCID: PMC4689141.
    Citations: 268     Fields:    
  59. Wyvekens N, Tsai SQ, Joung JK. Genome Editing in Human Cells Using CRISPR/Cas Nucleases. Curr Protoc Mol Biol. 2015 Oct 01; 112:31.3.1-31.3.18. PMID: 26423589.
    Citations: 6     Fields:    Translation:HumansCells
  60. Spisák S, Lawrenson K, Fu Y, Csabai I, Cottman RT, Seo JH, Haiman C, Han Y, Lenci R, Li Q, Tisza V, Szállási Z, Herbert ZT, Chabot M, Pomerantz M, Solymosi N, Gayther SA, Joung JK, Freedman ML. CAUSEL: an epigenome- and genome-editing pipeline for establishing function of noncoding GWAS variants. Nat Med. 2015 Nov; 21(11):1357-63. PMID: 26398868; PMCID: PMC4746056.
    Citations: 46     Fields:    Translation:HumansCells
  61. Hubbard BP, Badran AH, Zuris JA, Guilinger JP, Davis KM, Chen L, Tsai SQ, Sander JD, Joung JK, Liu DR. Continuous directed evolution of DNA-binding proteins to improve TALEN specificity. Nat Methods. 2015 Oct; 12(10):939-42. PMID: 26258293; PMCID: PMC4589463.
    Citations: 47     Fields:    Translation:Humans
  62. Joung JK. Unwanted mutations: Standards needed for gene-editing errors. Nature. 2015 Jul 09; 523(7559):158. PMID: 26156364.
    Citations: 7     Fields:    
  63. Wyvekens N, Topkar VV, Khayter C, Joung JK, Tsai SQ. Dimeric CRISPR RNA-Guided FokI-dCas9 Nucleases Directed by Truncated gRNAs for Highly Specific Genome Editing. Hum Gene Ther. 2015 Jul; 26(7):425-31. PMID: 26068112; PMCID: PMC4509490.
    Citations: 67     Fields:    Translation:HumansCells
  64. Kleinstiver BP, Prew MS, Tsai SQ, Topkar VV, Nguyen NT, Zheng Z, Gonzales AP, Li Z, Peterson RT, Yeh JR, Aryee MJ, Joung JK. Engineered CRISPR-Cas9 nucleases with altered PAM specificities. Nature. 2015 Jul 23; 523(7561):481-5. PMID: 26098369.
    Citations: 666     Fields:    Translation:HumansAnimalsCells
  65. Rogers JM, Barrera LA, Reyon D, Sander JD, Kellis M, Joung JK, Bulyk ML. Context influences on TALE-DNA binding revealed by quantitative profiling. Nat Commun. 2015 Jun 11; 6:7440. PMID: 26067805.
    Citations: 16     Fields:    Translation:Cells
  66. Rahman SH, Kuehle J, Reimann C, Mlambo T, Alzubi J, Maeder ML, Riedel H, Fisch P, Cantz T, Rudolph C, Mussolino C, Joung JK, Schambach A, Cathomen T. Rescue of DNA-PK Signaling and T-Cell Differentiation by Targeted Genome Editing in a prkdc Deficient iPSC Disease Model. PLoS Genet. 2015 May; 11(5):e1005239. PMID: 26000857; PMCID: PMC4441453.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
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  138. Cathomen T, Joung JK. Zinc-finger nucleases: the next generation emerges. Mol Ther. 2008 Jul; 16(7):1200-7. PMID: 18545224.
    Citations: 121     Fields:    Translation:HumansAnimalsCells
  139. Ramirez CL, Foley JE, Wright DA, Müller-Lerch F, Rahman SH, Cornu TI, Winfrey RJ, Sander JD, Fu F, Townsend JA, Cathomen T, Voytas DF, Joung JK. Unexpected failure rates for modular assembly of engineered zinc fingers. Nat Methods. 2008 May; 5(5):374-5. PMID: 18446154.
    Citations: 161     Fields:    Translation:HumansCells
  140. Pruett-Miller SM, Connelly JP, Maeder ML, Joung JK, Porteus MH. Comparison of zinc finger nucleases for use in gene targeting in mammalian cells. Mol Ther. 2008 Apr; 16(4):707-17. PMID: 18334988.
    Citations: 55     Fields:    Translation:HumansCells
  141. Cornu TI, Thibodeau-Beganny S, Guhl E, Alwin S, Eichtinger M, Joung JK, Joung JK, Cathomen T. DNA-binding specificity is a major determinant of the activity and toxicity of zinc-finger nucleases. Mol Ther. 2008 Feb; 16(2):352-8. PMID: 18026168.
    Citations: 100     Fields:    Translation:HumansCells
  142. Meng X, Thibodeau-Beganny S, Jiang T, Joung JK, Wolfe SA. Profiling the DNA-binding specificities of engineered Cys2His2 zinc finger domains using a rapid cell-based method. Nucleic Acids Res. 2007; 35(11):e81. PMID: 17537811; PMCID: PMC1920264.
    Citations: 13     Fields:    Translation:Cells
  143. Sander JD, Zaback P, Joung JK, Voytas DF, Dobbs D. Zinc Finger Targeter (ZiFiT): an engineered zinc finger/target site design tool. Nucleic Acids Res. 2007 Jul; 35(Web Server issue):W599-605. PMID: 17526515; PMCID: PMC1933188.
    Citations: 118     Fields:    Translation:HumansCells
  144. Giesecke AV, Joung JK. The bacterial two-hybrid system as a reporter system for analyzing protein-protein interactions. CSH Protoc. 2007 Mar 01; 2007:pdb.prot4672. PMID: 21357036.
    Citations: 4     
  145. Thibodeau-Beganny S, Joung JK. Engineering Cys2His2 zinc finger domains using a bacterial cell-based two-hybrid selection system. Methods Mol Biol. 2007; 408:317-34. PMID: 18314590.
    Citations: 5     Fields:    Translation:Cells
  146. Giesecke AV, Fang R, Joung JK. Synthetic protein-protein interaction domains created by shuffling Cys2His2 zinc-fingers. Mol Syst Biol. 2006; 2:2006.2011. PMID: 16732192; PMCID: PMC1681485.
    Citations: 10     Fields:    Translation:Cells
  147. Meng X, Smith RM, Giesecke AV, Joung JK, Wolfe SA. Counter-selectable marker for bacterial-based interaction trap systems. Biotechniques. 2006 Feb; 40(2):179-84. PMID: 16526407.
    Citations: 11     Fields:    Translation:Cells
  148. Wright DA, Thibodeau-Beganny S, Sander JD, Winfrey RJ, Hirsh AS, Eichtinger M, Fu F, Porteus MH, Dobbs D, Voytas DF, Joung JK. Standardized reagents and protocols for engineering zinc finger nucleases by modular assembly. Nat Protoc. 2006; 1(3):1637-52. PMID: 17406455.
    Citations: 75     Fields:    Translation:Cells
  149. Vallet-Gely I, Donovan KE, Fang R, Joung JK, Dove SL. Repression of phase-variable cup gene expression by H-NS-like proteins in Pseudomonas aeruginosa. Proc Natl Acad Sci U S A. 2005 Aug 02; 102(31):11082-7. PMID: 16043713; PMCID: PMC1182424.
    Citations: 66     Fields:    Translation:Cells
  150. Serebriiskii IG, Fang R, Latypova E, Hopkins R, Vinson C, Joung JK, Golemis EA. A combined yeast/bacteria two-hybrid system: development and evaluation. Mol Cell Proteomics. 2005 Jun; 4(6):819-26. PMID: 15781424.
    Citations: 3     Fields:    Translation:AnimalsCells
  151. Nguyen-Hackley DH, Ramm E, Taylor CM, Joung JK, Dervan PB, Pabo CO. Allosteric inhibition of zinc-finger binding in the major groove of DNA by minor-groove binding ligands. Biochemistry. 2004 Apr 06; 43(13):3880-90. PMID: 15049695.
    Citations: 10     Fields:    Translation:HumansCells
  152. Thibodeau SA, Fang R, Joung JK. High-throughput beta-galactosidase assay for bacterial cell-based reporter systems. Biotechniques. 2004 Mar; 36(3):410-5. PMID: 15038156.
    Citations: 52     Fields:    Translation:Cells
  153. Thibodeau SA, Joung JK. An improved strategy for constructing "designer" Cys2His2 zinc finger proteins. Discov Med. 2003 Dec; 3(19):32-5. PMID: 20705034.
    Citations:    Fields:    
  154. Hurt JA, Thibodeau SA, Hirsh AS, Pabo CO, Joung JK. Highly specific zinc finger proteins obtained by directed domain shuffling and cell-based selection. Proc Natl Acad Sci U S A. 2003 Oct 14; 100(21):12271-6. PMID: 14527993; PMCID: PMC218748.
    Citations: 62     Fields:    Translation:HumansCells
  155. Joung JK. Identifying and modifying protein-DNA and protein-protein interactions using a bacterial two-hybrid selection system. J Cell Biochem Suppl. 2001; Suppl 37:53-7. PMID: 11842428.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  156. Dove SL, Joung JK, Hochschild A. Activation of prokaryotic transcription through arbitrary protein-protein contacts. Nature. 1997 Apr 10; 386(6625):627-30. PMID: 9121589.
    Citations: 112     Fields:    Translation:Cells
  157. Joung JK, Chung EH, King G, Yu C, Hirsh AS, Hochschild A. Genetic strategy for analyzing specificity of dimer formation: Escherichia coli cyclic AMP receptor protein mutant altered in its dimerization specificity. Genes Dev. 1995 Dec 01; 9(23):2986-96. PMID: 7498794.
    Citations: 10     Fields:    Translation:Cells
  158. Joung JK, Koepp DM, Hochschild A. Synergistic activation of transcription by bacteriophage lambda cI protein and E. coli cAMP receptor protein. Science. 1994 Sep 23; 265(5180):1863-6. PMID: 8091212.
    Citations: 26     Fields:    Translation:Cells
  159. Joung JK, Le LU, Hochschild A. Synergistic activation of transcription by Escherichia coli cAMP receptor protein. Proc Natl Acad Sci U S A. 1993 Apr 01; 90(7):3083-7. PMID: 7681995; PMCID: PMC46241.
    Citations: 27     Fields:    Translation:Cells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.