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profileJohan Paulsson, PH.D.

TitleProfessor of Systems Biology
InstitutionHarvard Medical School
DepartmentSystems Biology
AddressHarvard Medical School
Systems Biology - Alpert 536
200 Longwood Ave
Boston MA 02115
Phone617/432-5730
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Collapse Research 
Collapse research activities and funding
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
R01GM095784     (PAULSSON, JOHAN)Jul 1, 2011 - Jun 30, 2015
NIH/NIGMS
Stochastic Partitioning and Degradation of Macromolecules
Role: Principal Investigator

R01GM081563     (PAULSSON, JOHAN)Jul 1, 2007 - Jun 30, 2019
NIH/NIGMS
Limits and trade-offs of feedback control
Role: Principal Investigator

P50GM068763     (MURRAY, ANDREW W)Sep 8, 2003 - Aug 31, 2014
NIH/NIGMS
Biological Diversity: Generation, Control and Exploitation
Role: Co-Principal Investigator

Collapse Bibliographic 
Collapse selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Russell JR, Cabeen MT, Wiggins PA, Paulsson J, Losick R. Noise in a phosphorelay drives stochastic entry into sporulation in Bacillus subtilis. EMBO J. 2017 Oct 02; 36(19):2856-2869. PMID: 28838935.
    View in: PubMed
  2. Cabeen MT, Russell JR, Paulsson J, Losick R. Use of a microfluidic platform to uncover basic features of energy and environmental stress responses in individual cells of Bacillus subtilis. PLoS Genet. 2017 Jul; 13(7):e1006901. PMID: 28727759.
    View in: PubMed
  3. Reuveni S, Ehrenberg M, Paulsson J. Ribosomes are optimized for autocatalytic production. Nature. 2017 Jul 19; 547(7663):293-297. PMID: 28726822.
    View in: PubMed
  4. Paulsson J, El Karoui M, Lindell M, Hughes D. The processive kinetics of gene conversion in bacteria. Mol Microbiol. 2017 Jun; 104(5):752-760. PMID: 28256783.
    View in: PubMed
  5. Ramachandran R, Jha J, Paulsson J, Chattoraj D. Random versus Cell Cycle-Regulated Replication Initiation in Bacteria: Insights from Studying Vibrio cholerae Chromosome 2. Microbiol Mol Biol Rev. 2017 Mar; 81(1). PMID: 27903655.
    View in: PubMed
  6. Potvin-Trottier L, Lord ND, Vinnicombe G, Paulsson J. Synchronous long-term oscillations in a synthetic gene circuit. Nature. 2016 10 27; 538(7626):514-517. PMID: 27732583.
    View in: PubMed
  7. Okumus B, Landgraf D, Lai GC, Bakshi S, Arias-Castro JC, Yildiz S, Huh D, Fernandez-Lopez R, Peterson CN, Toprak E, El Karoui M, Paulsson J. Corrigendum: Mechanical slowing-down of cytoplasmic diffusion allows in vivo counting of proteins in individual cells. Nat Commun. 2016 Jun 24; 7:12130. PMID: 27338979; PMCID: PMC4931014.
  8. Okumus B, Landgraf D, Lai GC, Bakhsi S, Arias-Castro JC, Yildiz S, Huh D, Fernandez-Lopez R, Peterson CN, Toprak E, El Karoui M, Paulsson J. Mechanical slowing-down of cytoplasmic diffusion allows in vivo counting of proteins in individual cells. Nat Commun. 2016 May 18; 7:11641. PMID: 27189321; PMCID: PMC4873973.
  9. Hilfinger A, Norman TM, Paulsson J. Exploiting Natural Fluctuations to Identify Kinetic Mechanisms in Sparsely Characterized Systems. Cell Syst. 2016 Apr 27; 2(4):251-9. PMID: 27135537.
    View in: PubMed
  10. Uphoff S, Lord ND, Okumus B, Potvin-Trottier L, Sherratt DJ, Paulsson J. Stochastic activation of a DNA damage response causes cell-to-cell mutation rate variation. Science. 2016 Mar 04; 351(6277):1094-7. PMID: 26941321; PMCID: PMC4827329.
  11. Hilfinger A, Norman TM, Vinnicombe G, Paulsson J. Constraints on Fluctuations in Sparsely Characterized Biological Systems. Phys Rev Lett. 2016 Feb 05; 116(5):058101. PMID: 26894735; PMCID: PMC4834202.
  12. Ke N, Landgraf D, Paulsson J, Berkmen M. Visualization of Periplasmic and Cytoplasmic Proteins with a Self-Labeling Protein Tag. J Bacteriol. 2016 Jan 19; 198(7):1035-43. PMID: 26787765; PMCID: PMC4800872.
  13. Jajoo R, Jung Y, Huh D, Viana MP, Rafelski SM, Springer M, Paulsson J. Accurate concentration control of mitochondria and nucleoids. Science. 2016 Jan 08; 351(6269):169-72. PMID: 26744405; PMCID: PMC4823142.
  14. Norman TM, Lord ND, Paulsson J, Losick R. Stochastic Switching of Cell Fate in Microbes. Annu Rev Microbiol. 2015; 69:381-403. PMID: 26332088.
    View in: PubMed
  15. Hilfinger A, Paulsson J. Systems biology: Defiant daughters and coordinated cousins. Nature. 2015 Mar 26; 519(7544):422-3. PMID: 25762142.
    View in: PubMed
  16. Norman TM, Lord ND, Paulsson J, Losick R. Memory and modularity in cell-fate decision making. Nature. 2013 Nov 28; 503(7477):481-486. PMID: 24256735; PMCID: PMC4019345.
  17. Lau BT, Malkus P, Paulsson J. New quantitative methods for measuring plasmid loss rates reveal unexpected stability. Plasmid. 2013 Nov; 70(3):353-61. PMID: 24042048; PMCID: PMC3966108.
  18. Toprak E, Veres A, Yildiz S, Pedraza JM, Chait R, Paulsson J, Kishony R. Building a morbidostat: an automated continuous-culture device for studying bacterial drug resistance under dynamically sustained drug inhibition. Nat Protoc. 2013 Mar; 8(3):555-67. PMID: 23429717; PMCID: PMC3708598.
  19. Hilfinger A, Chen M, Paulsson J. Using temporal correlations and full distributions to separate intrinsic and extrinsic fluctuations in biological systems. Phys Rev Lett. 2012 Dec 14; 109(24):248104. PMID: 23368387; PMCID: PMC3697929.
  20. Landgraf D, Okumus B, Chien P, Baker TA, Paulsson J. Segregation of molecules at cell division reveals native protein localization. Nat Methods. 2012 Apr 08; 9(5):480-2. PMID: 22484850; PMCID: PMC3779060.
  21. Tal S, Paulsson J. Evaluating quantitative methods for measuring plasmid copy numbers in single cells. Plasmid. 2012 Mar; 67(2):167-73. PMID: 22305922; PMCID: PMC3709585.
  22. Huh D, Paulsson J. Random partitioning of molecules at cell division. Proc Natl Acad Sci U S A. 2011 Sep 06; 108(36):15004-9. PMID: 21873252; PMCID: PMC3169110.
  23. Hilfinger A, Paulsson J. Separating intrinsic from extrinsic fluctuations in dynamic biological systems. Proc Natl Acad Sci U S A. 2011 Jul 19; 108(29):12167-72. PMID: 21730172; PMCID: PMC3141918.
  24. Huh D, Paulsson J. Non-genetic heterogeneity from stochastic partitioning at cell division. Nat Genet. 2011 Feb; 43(2):95-100. PMID: 21186354; PMCID: PMC3208402.
  25. Lestas I, Vinnicombe G, Paulsson J. Fundamental limits on the suppression of molecular fluctuations. Nature. 2010 Sep 09; 467(7312):174-8. PMID: 20829788; PMCID: PMC2996232.
  26. Usui K, Hulleman JD, Paulsson JF, Siegel SJ, Powers ET, Kelly JW. Site-specific modification of Alzheimer's peptides by cholesterol oxidation products enhances aggregation energetics and neurotoxicity. Proc Natl Acad Sci U S A. 2009 Nov 03; 106(44):18563-8. PMID: 19841277; PMCID: PMC2774025.
  27. Pedraza JM, Paulsson J. Effects of molecular memory and bursting on fluctuations in gene expression. Science. 2008 Jan 18; 319(5861):339-43. PMID: 18202292.
    View in: PubMed
  28. Paulsson JF, Schultz SW, Köhler M, Leibiger I, Berggren PO, Westermark GT. Real-time monitoring of apoptosis by caspase-3-like protease induced FRET reduction triggered by amyloid aggregation. Exp Diabetes Res. 2008; 2008:865850. PMID: 18566681; PMCID: PMC2426809.
  29. Pedraza JM, Paulsson J. Random timing in signaling cascades. Mol Syst Biol. 2007; 3:81. PMID: 17299417; PMCID: PMC1828750.
  30. Rando OJ, Paulsson J. Noisy silencing of chromatin. Dev Cell. 2006 Aug; 11(2):134-6. PMID: 16890152.
    View in: PubMed
  31. Paulsson J, Chattoraj DK. Origin inactivation in bacterial DNA replication control. Mol Microbiol. 2006 Jul; 61(1):9-15. PMID: 16824091.
    View in: PubMed
  32. Bar-Even A, Paulsson J, Maheshri N, Carmi M, O'Shea E, Pilpel Y, Barkai N. Noise in protein expression scales with natural protein abundance. Nat Genet. 2006 Jun; 38(6):636-43. PMID: 16715097.
    View in: PubMed
  33. Springer M, Paulsson J. Biological physics: harmonies from noise. Nature. 2006 Jan 05; 439(7072):27-8. PMID: 16397487.
    View in: PubMed
  34. Golding I, Paulsson J, Zawilski SM, Cox EC. Real-time kinetics of gene activity in individual bacteria. Cell. 2005 Dec 16; 123(6):1025-36. PMID: 16360033.
    View in: PubMed
  35. Paulsson J. Prime movers of noisy gene expression. Nat Genet. 2005 Sep; 37(9):925-6. PMID: 16132049.
    View in: PubMed
  36. Das N, Valjavec-Gratian M, Basuray AN, Fekete RA, Papp PP, Paulsson J, Chattoraj DK. Multiple homeostatic mechanisms in the control of P1 plasmid replication. Proc Natl Acad Sci U S A. 2005 Feb 22; 102(8):2856-61. PMID: 15708977; PMCID: PMC549481.
  37. Paulsson J. Summing up the noise in gene networks. Nature. 2004 Jan 29; 427(6973):415-8. PMID: 14749823.
    View in: PubMed
  38. Olsson JA, Paulsson J, Nordström K. Effect of the CopB auxiliary replication control system on stability of maintenance of Par(+) plasmid R1. J Bacteriol. 2004 Jan; 186(1):207-11. PMID: 14679240; PMCID: PMC303431.
  39. Elf J, Paulsson J, Berg OG, Ehrenberg M. Near-critical phenomena in intracellular metabolite pools. Biophys J. 2003 Jan; 84(1):154-70. PMID: 12524272; PMCID: PMC1302600.
  40. Paulsson J. Multileveled selection on plasmid replication. Genetics. 2002 Aug; 161(4):1373-84. PMID: 12238464; PMCID: PMC1462198.
  41. Park K, Han E, Paulsson J, Chattoraj DK. Origin pairing ('handcuffing') as a mode of negative control of P1 plasmid copy number. EMBO J. 2001 Dec 17; 20(24):7323-32. PMID: 11743008; PMCID: PMC125786.
  42. Paulsson J, Ehrenberg M. Noise in a minimal regulatory network: plasmid copy number control. Q Rev Biophys. 2001 Feb; 34(1):1-59. PMID: 11388089.
    View in: PubMed
  43. Berg OG, Paulsson J, Ehrenberg M. Fluctuations in repressor control: thermodynamic constraints on stochastic focusing. Biophys J. 2000 Dec; 79(6):2944-53. PMID: 11106602; PMCID: PMC1301173.
  44. Berg OG, Paulsson J, Ehrenberg M. Fluctuations and quality of control in biological cells: zero-order ultrasensitivity reinvestigated. Biophys J. 2000 Sep; 79(3):1228-36. PMID: 10968987; PMCID: PMC1301019.
  45. Paulsson J, Berg OG, Ehrenberg M. Stochastic focusing: fluctuation-enhanced sensitivity of intracellular regulation. Proc Natl Acad Sci U S A. 2000 Jun 20; 97(13):7148-53. PMID: 10852944; PMCID: PMC16514.
  46. Paulsson J, Ehrenberg M. Random signal fluctuations can reduce random fluctuations in regulated components of chemical regulatory networks. Phys Rev Lett. 2000 Jun 05; 84(23):5447-50. PMID: 10990965.
    View in: PubMed
  47. Paulsson J, Ehrenberg M. Molecular clocks reduce plasmid loss rates: the R1 case. J Mol Biol. 2000 Mar 17; 297(1):179-92. PMID: 10704315.
    View in: PubMed
  48. Paulsson J, Ehrenberg M. Trade-off between segregational stability and metabolic burden: a mathematical model of plasmid ColE1 replication control. J Mol Biol. 1998 May 29; 279(1):73-88. PMID: 9636701.
    View in: PubMed
  49. Paulsson J, Nordström K, Ehrenberg M. Requirements for rapid plasmid ColE1 copy number adjustments: a mathematical model of inhibition modes and RNA turnover rates. Plasmid. 1998; 39(3):215-34. PMID: 9571138.
    View in: PubMed
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