Harvard Catalyst Profiles

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Johan Paulsson, Ph.D.

Other Positions

The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01AI141966 (LEWIS, KIM) Nov 16, 2018 - Oct 31, 2022
    A general mechanism of persister formation
    Role: Co-Principal Investigator
  2. R01GM095784 (PAULSSON, JOHAN) Jul 1, 2011 - Jun 30, 2016
    Stochastic Partitioning and Degradation of Macromolecules
    Role: Principal Investigator
  3. R01GM081563 (PAULSSON, JOHAN) Jul 1, 2007 - Jun 30, 2020
    Limits and trade-offs of feedback control
    Role: Principal Investigator
  4. P50GM068763 (MURRAY, ANDREW W) Sep 8, 2003 - Aug 31, 2014
    Biological Diversity: Generation, Control and Exploitation
    Role: Co-Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Xu J, Suo W, Goulev Y, Sun L, Kerr L, Paulsson J, Zhang Y, Lao T. Handheld Microfluidic Filtration Platform Enables Rapid, Low-Cost, and Robust Self-Testing of SARS-CoV-2 Virus. Small. 2021 12; 17(52):e2104009. PMID: 34845827; PMCID: PMC8725168.
    Citations: 2     Fields:    Translation:HumansCells
  2. Bakshi S, Leoncini E, Baker C, Cañas-Duarte SJ, Okumus B, Paulsson J. Tracking bacterial lineages in complex and dynamic environments with applications for growth control and persistence. Nat Microbiol. 2021 06; 6(6):783-791. PMID: 34017106.
    Citations: 4     Fields:    Translation:Cells
  3. Riglar DT, Richmond DL, Potvin-Trottier L, Verdegaal AA, Naydich AD, Bakshi S, Leoncini E, Lyon LG, Paulsson J, Silver PA. Author Correction: Bacterial variability in the mammalian gut captured by a single-cell synthetic oscillator. Nat Commun. 2021 Mar 16; 12(1):1818. PMID: 33727556.
    Citations:    Fields:    
  4. Kuo J, Yuan R, Sánchez C, Paulsson J, Silver PA. Toward a translationally independent RNA-based synthetic oscillator using deactivated CRISPR-Cas. Nucleic Acids Res. 2020 08 20; 48(14):8165-8177. PMID: 32609820; PMCID: PMC7430638.
    Citations: 5     Fields:    Translation:Cells
  5. Basan M, Honda T, Christodoulou D, Hörl M, Chang YF, Leoncini E, Mukherjee A, Okano H, Taylor BR, Silverman JM, Sanchez C, Williamson JR, Paulsson J, Hwa T, Sauer U. A universal trade-off between growth and lag in fluctuating environments. Nature. 2020 08; 584(7821):470-474. PMID: 32669712.
    Citations: 26     Fields:    Translation:AnimalsCells
  6. Luro S, Potvin-Trottier L, Okumus B, Paulsson J. Isolating live cells after high-throughput, long-term, time-lapse microscopy. Nat Methods. 2020 01; 17(1):93-100. PMID: 31768062.
    Citations: 7     Fields:    Translation:Cells
  7. Riglar DT, Richmond DL, Potvin-Trottier L, Verdegaal AA, Naydich AD, Bakshi S, Leoncini E, Lyon LG, Paulsson J, Silver PA. Bacterial variability in the mammalian gut captured by a single-cell synthetic oscillator. Nat Commun. 2019 10 11; 10(1):4665. PMID: 31604953.
    Citations: 14     Fields:    Translation:AnimalsCells
  8. Lord ND, Norman TM, Yuan R, Bakshi S, Losick R, Paulsson J. Stochastic antagonism between two proteins governs a bacterial cell fate switch. Science. 2019 10 04; 366(6461):116-120. PMID: 31604312.
    Citations: 12     Fields:    Translation:Cells
  9. Yan J, Hilfinger A, Vinnicombe G, Paulsson J. Kinetic Uncertainty Relations for the Control of Stochastic Reaction Networks. Phys Rev Lett. 2019 Sep 06; 123(10):108101. PMID: 31573304.
    Citations: 1     Fields:    
  10. Potvin-Trottier L, Luro S, Paulsson J. Microfluidics and single-cell microscopy to study stochastic processes in bacteria. Curr Opin Microbiol. 2018 06; 43:186-192. PMID: 29494845.
    Citations: 20     Fields:    Translation:Cells
  11. Okumus B, Baker CJ, Arias-Castro JC, Lai GC, Leoncini E, Bakshi S, Luro S, Landgraf D, Paulsson J. Single-cell microscopy of suspension cultures using a microfluidics-assisted cell screening platform. Nat Protoc. 2018 Jan; 13(1):170-194. PMID: 29266097.
    Citations: 9     Fields:    Translation:Cells
  12. Russell JR, Cabeen MT, Wiggins PA, Paulsson J, Losick R. Noise in a phosphorelay drives stochastic entry into sporulation in Bacillus subtilis. EMBO J. 2017 10 02; 36(19):2856-2869. PMID: 28838935.
    Citations: 20     Fields:    Translation:Cells
  13. Cabeen MT, Russell JR, Paulsson J, Losick R. Use of a microfluidic platform to uncover basic features of energy and environmental stress responses in individual cells of Bacillus subtilis. PLoS Genet. 2017 Jul; 13(7):e1006901. PMID: 28727759; PMCID: PMC5542698.
    Citations: 13     Fields:    Translation:Cells
  14. Reuveni S, Ehrenberg M, Paulsson J. Ribosomes are optimized for autocatalytic production. Nature. 2017 07 19; 547(7663):293-297. PMID: 28726822.
    Citations: 21     Fields:    Translation:Cells
  15. Paulsson J, El Karoui M, Lindell M, Hughes D. The processive kinetics of gene conversion in bacteria. Mol Microbiol. 2017 Jun; 104(5):752-760. PMID: 28256783; PMCID: PMC5485169.
    Citations: 9     Fields:    Translation:Cells
  16. Ramachandran R, Jha J, Paulsson J, Chattoraj D. Random versus Cell Cycle-Regulated Replication Initiation in Bacteria: Insights from Studying Vibrio cholerae Chromosome 2. Microbiol Mol Biol Rev. 2017 03; 81(1). PMID: 27903655; PMCID: PMC5312244.
    Citations: 14     Fields:    Translation:Cells
  17. Potvin-Trottier L, Lord ND, Vinnicombe G, Paulsson J. Synchronous long-term oscillations in a synthetic gene circuit. Nature. 2016 10 27; 538(7626):514-517. PMID: 27732583.
    Citations: 76     Fields:    Translation:Cells
  18. Okumus B, Landgraf D, Lai GC, Bakshi S, Arias-Castro JC, Yildiz S, Huh D, Fernandez-Lopez R, Peterson CN, Toprak E, El Karoui M, Paulsson J. Corrigendum: Mechanical slowing-down of cytoplasmic diffusion allows in vivo counting of proteins in individual cells. Nat Commun. 2016 06 24; 7:12130. PMID: 27338979.
    Citations: 1     Fields:    
  19. Okumus B, Landgraf D, Lai GC, Bakshi S, Arias-Castro JC, Yildiz S, Huh D, Fernandez-Lopez R, Peterson CN, Toprak E, El Karoui M, Paulsson J. Mechanical slowing-down of cytoplasmic diffusion allows in vivo counting of proteins in individual cells. Nat Commun. 2016 05 18; 7:11641. PMID: 27189321.
    Citations: 22     Fields:    Translation:Cells
  20. Hilfinger A, Norman TM, Paulsson J. Exploiting Natural Fluctuations to Identify Kinetic Mechanisms in Sparsely Characterized Systems. Cell Syst. 2016 Apr 27; 2(4):251-9. PMID: 27135537.
    Citations: 11     Fields:    
  21. Uphoff S, Lord ND, Okumus B, Potvin-Trottier L, Sherratt DJ, Paulsson J. Stochastic activation of a DNA damage response causes cell-to-cell mutation rate variation. Science. 2016 Mar 04; 351(6277):1094-7. PMID: 26941321; PMCID: PMC4827329.
    Citations: 58     Fields:    Translation:Cells
  22. Hilfinger A, Norman TM, Vinnicombe G, Paulsson J. Constraints on Fluctuations in Sparsely Characterized Biological Systems. Phys Rev Lett. 2016 Feb 05; 116(5):058101. PMID: 26894735; PMCID: PMC4834202.
    Citations: 9     Fields:    
  23. Ke N, Landgraf D, Paulsson J, Berkmen M. Visualization of Periplasmic and Cytoplasmic Proteins with a Self-Labeling Protein Tag. J Bacteriol. 2016 Jan 19; 198(7):1035-43. PMID: 26787765; PMCID: PMC4800872.
    Citations: 21     Fields:    Translation:Cells
  24. Jajoo R, Jung Y, Huh D, Viana MP, Rafelski SM, Springer M, Paulsson J. Accurate concentration control of mitochondria and nucleoids. Science. 2016 Jan 08; 351(6269):169-72. PMID: 26744405.
    Citations: 33     Fields:    Translation:AnimalsCells
  25. Norman TM, Lord ND, Paulsson J, Losick R. Stochastic Switching of Cell Fate in Microbes. Annu Rev Microbiol. 2015; 69:381-403. PMID: 26332088.
    Citations: 68     Fields:    Translation:Cells
  26. Hilfinger A, Paulsson J. Systems biology: Defiant daughters and coordinated cousins. Nature. 2015 Mar 26; 519(7544):422-3. PMID: 25762142.
    Citations: 2     Fields:    Translation:Animals
  27. Norman TM, Lord ND, Paulsson J, Losick R. Memory and modularity in cell-fate decision making. Nature. 2013 Nov 28; 503(7477):481-486. PMID: 24256735.
    Citations: 100     Fields:    Translation:Cells
  28. Lau BT, Malkus P, Paulsson J. New quantitative methods for measuring plasmid loss rates reveal unexpected stability. Plasmid. 2013 Nov; 70(3):353-61. PMID: 24042048.
    Citations: 26     Fields:    Translation:Cells
  29. Toprak E, Veres A, Yildiz S, Pedraza JM, Chait R, Paulsson J, Kishony R. Building a morbidostat: an automated continuous-culture device for studying bacterial drug resistance under dynamically sustained drug inhibition. Nat Protoc. 2013 Mar; 8(3):555-67. PMID: 23429717.
    Citations: 51     Fields:    Translation:Cells
  30. Hilfinger A, Chen M, Paulsson J. Using temporal correlations and full distributions to separate intrinsic and extrinsic fluctuations in biological systems. Phys Rev Lett. 2012 Dec 14; 109(24):248104. PMID: 23368387.
    Citations: 5     Fields:    
  31. Landgraf D, Okumus B, Chien P, Baker TA, Paulsson J. Segregation of molecules at cell division reveals native protein localization. Nat Methods. 2012 Apr 08; 9(5):480-2. PMID: 22484850.
    Citations: 168     Fields:    Translation:Cells
  32. Tal S, Paulsson J. Evaluating quantitative methods for measuring plasmid copy numbers in single cells. Plasmid. 2012 Mar; 67(2):167-73. PMID: 22305922.
    Citations: 12     Fields:    Translation:Cells
  33. Huh D, Paulsson J. Random partitioning of molecules at cell division. Proc Natl Acad Sci U S A. 2011 Sep 06; 108(36):15004-9. PMID: 21873252.
    Citations: 83     Fields:    
  34. Hilfinger A, Paulsson J. Separating intrinsic from extrinsic fluctuations in dynamic biological systems. Proc Natl Acad Sci U S A. 2011 Jul 19; 108(29):12167-72. PMID: 21730172.
    Citations: 96     Fields:    
  35. Huh D, Paulsson J. Non-genetic heterogeneity from stochastic partitioning at cell division. Nat Genet. 2011 Feb; 43(2):95-100. PMID: 21186354.
    Citations: 157     Fields:    Translation:Cells
  36. Lestas I, Vinnicombe G, Paulsson J. Fundamental limits on the suppression of molecular fluctuations. Nature. 2010 Sep 09; 467(7312):174-8. PMID: 20829788.
    Citations: 143     Fields:    Translation:AnimalsCells
  37. Usui K, Hulleman JD, Paulsson JF, Siegel SJ, Powers ET, Kelly JW. Site-specific modification of Alzheimer's peptides by cholesterol oxidation products enhances aggregation energetics and neurotoxicity. Proc Natl Acad Sci U S A. 2009 Nov 03; 106(44):18563-8. PMID: 19841277.
    Citations: 28     Fields:    Translation:AnimalsCells
  38. Pedraza JM, Paulsson J. Effects of molecular memory and bursting on fluctuations in gene expression. Science. 2008 Jan 18; 319(5861):339-43. PMID: 18202292.
    Citations: 145     Fields:    Translation:Cells
  39. Paulsson JF, Schultz SW, Köhler M, Leibiger I, Berggren PO, Westermark GT. Real-time monitoring of apoptosis by caspase-3-like protease induced FRET reduction triggered by amyloid aggregation. Exp Diabetes Res. 2008; 2008:865850. PMID: 18566681.
    Citations: 8     Fields:    Translation:AnimalsCells
  40. Pedraza JM, Paulsson J. Random timing in signaling cascades. Mol Syst Biol. 2007; 3:81. PMID: 17299417; PMCID: PMC1828750.
    Citations: 6     Fields:    Translation:Cells
  41. Rando OJ, Paulsson J. Noisy silencing of chromatin. Dev Cell. 2006 Aug; 11(2):134-6. PMID: 16890152.
    Citations: 3     Fields:    Translation:AnimalsCells
  42. Paulsson J, Chattoraj DK. Origin inactivation in bacterial DNA replication control. Mol Microbiol. 2006 Jul; 61(1):9-15. PMID: 16824091.
    Citations: 19     Fields:    Translation:Cells
  43. Bar-Even A, Paulsson J, Maheshri N, Carmi M, O'Shea E, Pilpel Y, Barkai N. Noise in protein expression scales with natural protein abundance. Nat Genet. 2006 Jun; 38(6):636-43. PMID: 16715097.
    Citations: 361     Fields:    Translation:Cells
  44. Springer M, Paulsson J. Biological physics: harmonies from noise. Nature. 2006 Jan 05; 439(7072):27-8. PMID: 16397487.
    Citations: 13     Fields:    Translation:Cells
  45. Golding I, Paulsson J, Zawilski SM, Cox EC. Real-time kinetics of gene activity in individual bacteria. Cell. 2005 Dec 16; 123(6):1025-36. PMID: 16360033.
    Citations: 545     Fields:    Translation:Cells
  46. Paulsson J. Prime movers of noisy gene expression. Nat Genet. 2005 Sep; 37(9):925-6. PMID: 16132049.
    Citations: 5     Fields:    Translation:AnimalsCells
  47. Das N, Valjavec-Gratian M, Basuray AN, Fekete RA, Papp PP, Paulsson J, Chattoraj DK. Multiple homeostatic mechanisms in the control of P1 plasmid replication. Proc Natl Acad Sci U S A. 2005 Feb 22; 102(8):2856-61. PMID: 15708977; PMCID: PMC549481.
    Citations: 22     Fields:    Translation:Cells
  48. Paulsson J. Summing up the noise in gene networks. Nature. 2004 Jan 29; 427(6973):415-8. PMID: 14749823.
    Citations: 406     Fields:    Translation:AnimalsCells
  49. Olsson JA, Paulsson J, Nordström K. Effect of the CopB auxiliary replication control system on stability of maintenance of Par(+) plasmid R1. J Bacteriol. 2004 Jan; 186(1):207-11. PMID: 14679240.
    Citations: 6     Fields:    Translation:Cells
  50. Elf J, Paulsson J, Berg OG, Ehrenberg M. Near-critical phenomena in intracellular metabolite pools. Biophys J. 2003 Jan; 84(1):154-70. PMID: 12524272; PMCID: PMC1302600.
    Citations: 32     Fields:    Translation:Cells
  51. Paulsson J. Multileveled selection on plasmid replication. Genetics. 2002 Aug; 161(4):1373-84. PMID: 12238464.
    Citations: 39     Fields:    Translation:Cells
  52. Park K, Han E, Paulsson J, Chattoraj DK. Origin pairing ('handcuffing') as a mode of negative control of P1 plasmid copy number. EMBO J. 2001 Dec 17; 20(24):7323-32. PMID: 11743008; PMCID: PMC125786.
    Citations: 16     Fields:    Translation:Cells
  53. Paulsson J, Ehrenberg M. Noise in a minimal regulatory network: plasmid copy number control. Q Rev Biophys. 2001 Feb; 34(1):1-59. PMID: 11388089.
    Citations: 55     Fields:    Translation:Cells
  54. Berg OG, Paulsson J, Ehrenberg M. Fluctuations in repressor control: thermodynamic constraints on stochastic focusing. Biophys J. 2000 Dec; 79(6):2944-53. PMID: 11106602; PMCID: PMC1301173.
    Citations: 7     Fields:    
  55. Berg OG, Paulsson J, Ehrenberg M. Fluctuations and quality of control in biological cells: zero-order ultrasensitivity reinvestigated. Biophys J. 2000 Sep; 79(3):1228-36. PMID: 10968987; PMCID: PMC1301019.
    Citations: 39     Fields:    
  56. Paulsson J, Berg OG, Ehrenberg M. Stochastic focusing: fluctuation-enhanced sensitivity of intracellular regulation. Proc Natl Acad Sci U S A. 2000 Jun 20; 97(13):7148-53. PMID: 10852944; PMCID: PMC16514.
    Citations: 101     Fields:    Translation:HumansAnimalsCells
  57. Paulsson J, Ehrenberg M. Random signal fluctuations can reduce random fluctuations in regulated components of chemical regulatory networks. Phys Rev Lett. 2000 Jun 05; 84(23):5447-50. PMID: 10990965.
    Citations: 53     Fields:    Translation:Cells
  58. Paulsson J, Ehrenberg M. Molecular clocks reduce plasmid loss rates: the R1 case. J Mol Biol. 2000 Mar 17; 297(1):179-92. PMID: 10704315.
    Citations: 5     Fields:    Translation:Cells
  59. Paulsson J, Ehrenberg M. Trade-off between segregational stability and metabolic burden: a mathematical model of plasmid ColE1 replication control. J Mol Biol. 1998 May 29; 279(1):73-88. PMID: 9636701.
    Citations: 22     Fields:    Translation:Cells
  60. Paulsson J, Nordström K, Ehrenberg M. Requirements for rapid plasmid ColE1 copy number adjustments: a mathematical model of inhibition modes and RNA turnover rates. Plasmid. 1998; 39(3):215-34. PMID: 9571138.
    Citations: 11     Fields:    
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.