Harvard Catalyst Profiles

Contact, publication, and social network information about Harvard faculty and fellows.

Magali Saint-Geniez, Ph.D.

Title
Institution
Department
Address
Phone
Fax

Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01EY029269 (CONNOR, KIP M) Apr 1, 2019 - Mar 31, 2023
    NIH/NEI
    Sex dependent regulation of retinal degeneration
    Role: Co-Principal Investigator
  2. M2017138 (SAINT-GENIEZ, MAGALI) Jul 1, 2018 - Jun 30, 2020
    BrightFocus Foundation
    Investigating the role of PGC-1beta in neovascular AMD
    Role Description: This project aims to characterize the contribution of PGC-1b to neovascular AMD and to identify therapeutic methods for targeting pathway as therapy for advanced AMD.
    Role: PI
  3. ARI (SAINT-GENIEZ, MAGALI) Jul 1, 2017 - Jun 30, 2018
    Alcon Young Investigator Award
    Targeting RPE metabolism in AMD
    Role Description: This award supports on going research to elucidate fundamental questions on the contribution of metabolic alterations to RPE and photoreceptors’ oxidative stress and degeneration during AMD progression.
    Role: PI
  4. Special Scholars Award (SAINT-GENIEZ, MAGALI) Jul 1, 2015 - Jun 30, 2017
    Research to Prevent Blindness
    Energy failure and PGC-1 coactivators in photoreceptor degeneration following retinal detachment
    Role Description: This grant aimed to characterize the metabolic changes associated with retinal detachment.
    Role: PI
  5. R01EY023682 (ARANY, ZOLTAN P) Aug 1, 2013 - Jul 31, 2016
    NIH/NEI
    PGC-1 coactivators in photoreceptor development and survival
    Role: Co-Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Shu DY, Butcher E, Saint-Geniez M. EMT and EndMT: Emerging Roles in Age-Related Macular Degeneration. Int J Mol Sci. 2020 Jun 16; 21(12). PMID: 32560057.
    Citations:    
  2. Hu Z, Cano I, Saez-Torres KL, LeBlanc ME, Saint-Geniez M, Ng YS, Argüeso P, D'Amore PA. Elements of the Endomucin Extracellular Domain Essential for VEGF-Induced VEGFR2 Activity. Cells. 2020 Jun 05; 9(6). PMID: 32517158.
    Citations:    
  3. Yang J, LeBlanc ME, Cano I, Saez-Torres KL, Saint-Geniez M, Ng YS, D'Amore PA. ADAM10 and ADAM17 proteases mediate proinflammatory cytokine-induced and constitutive cleavage of endomucin from the endothelial surface. J Biol Chem. 2020 May 08; 295(19):6641-6651. PMID: 32193206.
    Citations:    
  4. McHugh KJ, Li D, Wang JC, Kwark L, Loo J, Macha V, Farsiu S, Kim LA, Saint-Geniez M. Computational modeling of retinal hypoxia and photoreceptor degeneration in patients with age-related macular degeneration. PLoS One. 2019; 14(6):e0216215. PMID: 31185022.
    Citations:    
  5. Rosales MAB, Shu DY, Iacovelli J, Saint-Geniez M. Correction: Loss of PGC-1a in RPE induces mesenchymal transition and promotes retinal degeneration. Life Sci Alliance. 2019 Jun; 2(3). PMID: 31142639.
    Citations:    
  6. LeBlanc ME, Saez-Torres KL, Cano I, Hu Z, Saint-Geniez M, Ng YS, D'Amore PA. Glycocalyx regulation of vascular endothelial growth factor receptor 2 activity. FASEB J. 2019 08; 33(8):9362-9373. PMID: 31141406.
    Citations:    
  7. Rosales MAB, Shu DY, Iacovelli J, Saint-Geniez M. Loss of PGC-1a in RPE induces mesenchymal transition and promotes retinal degeneration. Life Sci Alliance. 2019 06; 2(3). PMID: 31101737.
    Citations:    
  8. Satish S, Philipose H, Rosales MAB, Saint-Geniez M. Pharmaceutical Induction of PGC-1a Promotes Retinal Pigment Epithelial Cell Metabolism and Protects against Oxidative Damage. Oxid Med Cell Longev. 2018; 2018:9248640. PMID: 30524663.
    Citations:    Fields:    Translation:HumansCells
  9. Yoshie H, Koushki N, Kaviani R, Tabatabaei M, Rajendran K, Dang Q, Husain A, Yao S, Li C, Sullivan JK, Saint-Geniez M, Krishnan R, Ehrlicher AJ. Traction Force Screening Enabled by Compliant PDMS Elastomers. Biophys J. 2018 05 08; 114(9):2194-2199. PMID: 29742412.
    Citations:    Fields:    
  10. Park-Windhol C, Ng YS, Yang J, Primo V, Saint-Geniez M, D'Amore PA. Endomucin inhibits VEGF-induced endothelial cell migration, growth, and morphogenesis by modulating VEGFR2 signaling. Sci Rep. 2017 12 07; 7(1):17138. PMID: 29215001.
    Citations: 3     Fields:    
  11. Gerhardt MJ, Marsh JA, Morrison M, Kazlauskas A, Khadka A, Rosenkranz S, DeAngelis MM, Saint-Geniez M, Jacobo SMP. ER stress-induced aggresome trafficking of HtrA1 protects against proteotoxicity. J Mol Cell Biol. 2017 12 01; 9(6):533. PMID: 29040612.
    Citations:    Fields:    
  12. Gerhardt MJ, Marsh JA, Morrison M, Kazlauskas A, Khadka A, Rosenkranz S, DeAngelis MM, Saint-Geniez M, Jacobo SMP. ER stress-induced aggresome trafficking of HtrA1 protects against proteotoxicity. J Mol Cell Biol. 2017 12 01; 9(6):516-532. PMID: 28992183.
    Citations:    Fields:    
  13. Machuca-Parra AI, Bigger-Allen AA, Sanchez AV, Boutabla A, Cardona-Vélez J, Amarnani D, Saint-Geniez M, Siebel CW, Kim LA, D'Amore PA, Arboleda-Velasquez JF. Therapeutic antibody targeting of Notch3 signaling prevents mural cell loss in CADASIL. J Exp Med. 2017 Aug 07; 214(8):2271-2282. PMID: 28698285.
    Citations:    Fields:    Translation:AnimalsCells
  14. Saint-Geniez M, Rosales MAB. Eyeing the Fountain of Youth. Cell Stem Cell. 2017 05 04; 20(5):583-584. PMID: 28475881.
    Citations:    Fields:    Translation:HumansCells
  15. Spencer C, Abend S, McHugh KJ, Saint-Geniez M. Identification of a synergistic interaction between endothelial cells and retinal pigment epithelium. J Cell Mol Med. 2017 10; 21(10):2542-2552. PMID: 28402065.
    Citations: 3     Fields:    Translation:HumansCells
  16. Iacovelli J, Rowe GC, Khadka A, Diaz-Aguilar D, Spencer C, Arany Z, Saint-Geniez M. PGC-1a Induces Human RPE Oxidative Metabolism and Antioxidant Capacity. Invest Ophthalmol Vis Sci. 2016 Mar; 57(3):1038-51. PMID: 26962700.
    Citations: 14     Fields:    Translation:HumansCells
  17. Zahr A, Alcaide P, Yang J, Jones A, Gregory M, dela Paz NG, Patel-Hett S, Nevers T, Koirala A, Luscinskas FW, Saint-Geniez M, Ksander B, D'Amore PA, Argüeso P. Endomucin prevents leukocyte-endothelial cell adhesion and has a critical role under resting and inflammatory conditions. Nat Commun. 2016 Feb 02; 7:10363. PMID: 26831939.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  18. Sánchez-Palencia DM, Bigger-Allen A, Saint-Geniez M, Arboleda-Velásquez JF, D'Amore PA. Coculture Assays for Endothelial Cells-Mural Cells Interactions. Methods Mol Biol. 2016; 1464:35-47. PMID: 27858354.
    Citations:    Fields:    Translation:HumansAnimalsCells
  19. Kim C, Smith KE, Castillejos A, Diaz-Aguilar D, Saint-Geniez M, Connor KM. The alternative complement pathway aids in vascular regression during the early stages of a murine model of proliferative retinopathy. FASEB J. 2016 Mar; 30(3):1300-5. PMID: 26631482.
    Citations: 5     Fields:    Translation:Animals
  20. Saint-Geniez M, Ghelfi E, Liang X, Yu C, Spencer C, Abend S, Hotamisligil G, Cataltepe S. Fatty acid binding protein 4 deficiency protects against oxygen-induced retinopathy in mice. PLoS One. 2014; 9(5):e96253. PMID: 24802082.
    Citations: 5     Fields:    Translation:Animals
  21. Wang J, Iacovelli J, Spencer C, Saint-Geniez M. Direct effect of sodium iodate on neurosensory retina. Invest Ophthalmol Vis Sci. 2014 Mar 28; 55(3):1941-53. PMID: 24481259.
    Citations: 22     Fields:    Translation:Animals
  22. McHugh KJ, Tao SL, Saint-Geniez M. Porous poly(e-caprolactone) scaffolds for retinal pigment epithelium transplantation. Invest Ophthalmol Vis Sci. 2014 Mar 25; 55(3):1754-62. PMID: 24550370.
    Citations: 8     Fields:    Translation:HumansCells
  23. Sweigard JH, Yanai R, Gaissert P, Saint-Geniez M, Kataoka K, Thanos A, Stahl GL, Lambris JD, Connor KM. The alternative complement pathway regulates pathological angiogenesis in the retina. FASEB J. 2014 Jul; 28(7):3171-82. PMID: 24668752.
    Citations: 15     Fields:    Translation:HumansAnimalsCells
  24. McHugh KJ, Saint-Geniez M, Tao SL. Topographical control of ocular cell types for tissue engineering. J Biomed Mater Res B Appl Biomater. 2013 Nov; 101(8):1571-84. PMID: 23744715.
    Citations: 5     Fields:    Translation:HumansCells
  25. McHugh KJ, Tao SL, Saint-Geniez M. A novel porous scaffold fabrication technique for epithelial and endothelial tissue engineering. J Mater Sci Mater Med. 2013 Jul; 24(7):1659-70. PMID: 23625319.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  26. Ford KM, Saint-Geniez M, Walshe TE, D'Amore PA. Expression and role of VEGF--a in the ciliary body. Invest Ophthalmol Vis Sci. 2012 Nov 07; 53(12):7520-7. PMID: 23081980.
    Citations: 9     Fields:    Translation:Animals
  27. Saint-Geniez M, Jiang A, Abend S, Liu L, Sweigard H, Connor KM, Arany Z. PGC-1a regulates normal and pathological angiogenesis in the retina. Am J Pathol. 2013 Jan; 182(1):255-65. PMID: 23141926.
    Citations: 16     Fields:    Translation:HumansAnimals
  28. dela Paz NG, Walshe TE, Leach LL, Saint-Geniez M, D'Amore PA. Role of shear-stress-induced VEGF expression in endothelial cell survival. J Cell Sci. 2012 Feb 15; 125(Pt 4):831-43. PMID: 22399811.
    Citations: 42     Fields:    Translation:HumansAnimalsCells
  29. Ford KM, Saint-Geniez M, Walshe T, Zahr A, D'Amore PA. Expression and role of VEGF in the adult retinal pigment epithelium. Invest Ophthalmol Vis Sci. 2011 Dec 09; 52(13):9478-87. PMID: 22058334.
    Citations: 41     Fields:    Translation:AnimalsCells
  30. Sekiyama E, Saint-Geniez M, Yoneda K, Hisatomi T, Nakao S, Walshe TE, Maruyama K, Hafezi-Moghadam A, Miller JW, Kinoshita S, D'Amore PA. Heat treatment of retinal pigment epithelium induces production of elastic lamina components and antiangiogenic activity. FASEB J. 2012 Feb; 26(2):567-75. PMID: 22067481.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  31. Darland DC, Cain JT, Berosik MA, Saint-Geniez M, Odens PW, Schaubhut GJ, Frisch S, Stemmer-Rachamimov A, Darland T, D'Amore PA. Vascular endothelial growth factor (VEGF) isoform regulation of early forebrain development. Dev Biol. 2011 Oct 01; 358(1):9-22. PMID: 21803034.
    Citations: 12     Fields:    Translation:Animals
  32. Bryan BA, Dennstedt E, Mitchell DC, Walshe TE, Noma K, Loureiro R, Saint-Geniez M, Campaigniac JP, Liao JK, D'Amore PA. RhoA/ROCK signaling is essential for multiple aspects of VEGF-mediated angiogenesis. FASEB J. 2010 Sep; 24(9):3186-95. PMID: 20400538.
    Citations: 76     Fields:    Translation:HumansAnimalsCells
  33. Saint-Geniez M, Kurihara T, Sekiyama E, Maldonado AE, D'Amore PA. An essential role for RPE-derived soluble VEGF in the maintenance of the choriocapillaris. Proc Natl Acad Sci U S A. 2009 Nov 03; 106(44):18751-6. PMID: 19841260.
    Citations: 127     Fields:    Translation:AnimalsCells
  34. Walshe TE, Saint-Geniez M, Maharaj AS, Sekiyama E, Maldonado AE, D'Amore PA. TGF-beta is required for vascular barrier function, endothelial survival and homeostasis of the adult microvasculature. PLoS One. 2009; 4(4):e5149. PMID: 19340291.
    Citations: 51     Fields:    Translation:AnimalsCells
  35. Saint-Geniez M, Maharaj AS, Walshe TE, Tucker BA, Sekiyama E, Kurihara T, Darland DC, Young MJ, D'Amore PA. Endogenous VEGF is required for visual function: evidence for a survival role on müller cells and photoreceptors. PLoS One. 2008; 3(11):e3554. PMID: 18978936.
    Citations: 189     Fields:    Translation:AnimalsCells
  36. Saint-Geniez M, Kurihara T, D'Amore PA. Role of cell and matrix-bound VEGF isoforms in lens development. Invest Ophthalmol Vis Sci. 2009 Jan; 50(1):311-21. PMID: 18757513.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  37. Maharaj AS, Walshe TE, Saint-Geniez M, Venkatesha S, Maldonado AE, Himes NC, Matharu KS, Karumanchi SA, D'Amore PA. VEGF and TGF-beta are required for the maintenance of the choroid plexus and ependyma. J Exp Med. 2008 Feb 18; 205(2):491-501. PMID: 18268040.
    Citations: 45     Fields:    Translation:AnimalsCells
  38. Bryan BA, Walshe TE, Mitchell DC, Havumaki JS, Saint-Geniez M, Maharaj AS, Maldonado AE, D'Amore PA. Coordinated vascular endothelial growth factor expression and signaling during skeletal myogenic differentiation. Mol Biol Cell. 2008 Mar; 19(3):994-1006. PMID: 18094043.
    Citations: 38     Fields:    Translation:HumansAnimalsCells
  39. Cursiefen C, Chen L, Saint-Geniez M, Hamrah P, Jin Y, Rashid S, Pytowski B, Persaud K, Wu Y, Streilein JW, Dana R. Nonvascular VEGF receptor 3 expression by corneal epithelium maintains avascularity and vision. Proc Natl Acad Sci U S A. 2006 Jul 25; 103(30):11405-10. PMID: 16849433.
    Citations: 82     Fields:    Translation:HumansAnimalsCells
  40. Saint-Geniez M, Maldonado AE, D'Amore PA. VEGF expression and receptor activation in the choroid during development and in the adult. Invest Ophthalmol Vis Sci. 2006 Jul; 47(7):3135-42. PMID: 16799060.
    Citations: 62     Fields:    Translation:AnimalsCells
  41. Lutty GA, Chan-Ling T, Phelps DL, Adamis AP, Berns KI, Chan CK, Cole CH, D'Amore PA, Das A, Deng WT, Dobson V, Flynn JT, Friedlander M, Fulton A, Good WV, Grant MB, Hansen R, Hauswirth WW, Hardy RJ, Hinton DR, Hughes S, McLeod DS, Palmer EA, Patz A, Penn JS, Raisler BJ, Repka MX, Saint-Geniez M, Shaw LC, Shima DT, Smith BT, Smith LE, Tahija SG, Tasman W, Trese MT. Proceedings of the Third International Symposium on Retinopathy of Prematurity: an update on ROP from the lab to the nursery (November 2003, Anaheim, California). Mol Vis. 2006 May 23; 12:532-80. PMID: 16735995.
    Citations: 16     Fields:    Translation:Humans
  42. Maharaj AS, Saint-Geniez M, Maldonado AE, D'Amore PA. Vascular endothelial growth factor localization in the adult. Am J Pathol. 2006 Feb; 168(2):639-48. PMID: 16436677.
    Citations: 80     Fields:    Translation:AnimalsCells
  43. Saint-Geniez M, D'Amore PA. Development and pathology of the hyaloid, choroidal and retinal vasculature. Int J Dev Biol. 2004; 48(8-9):1045-58. PMID: 15558494.
    Citations: 114     Fields:    Translation:HumansAnimals
  44. Darland DC, Massingham LJ, Smith SR, Piek E, Saint-Geniez M, D'Amore PA. Pericyte production of cell-associated VEGF is differentiation-dependent and is associated with endothelial survival. Dev Biol. 2003 Dec 01; 264(1):275-88. PMID: 14623248.
    Citations: 112     Fields:    Translation:HumansAnimalsCells
  45. Le Gat L, Gogat K, Bouquet C, Saint-Geniez M, Darland D, Van Den Berghe L, Marchant D, Provost A, Perricaudet M, Menasche M, Abitbol M. In vivo adenovirus-mediated delivery of a uPA/uPAR antagonist reduces retinal neovascularization in a mouse model of retinopathy. Gene Ther. 2003 Dec; 10(25):2098-103. PMID: 14595383.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  46. Saint-Geniez M, Argence CB, Knibiehler B, Audigier Y. The msr/apj gene encoding the apelin receptor is an early and specific marker of the venous phenotype in the retinal vasculature. Gene Expr Patterns. 2003 Aug; 3(4):467-72. PMID: 12915314.
    Citations: 17     Fields:    Translation:Animals
  47. Saint-Geniez M, Masri B, Malecaze F, Knibiehler B, Audigier Y. Expression of the murine msr/apj receptor and its ligand apelin is upregulated during formation of the retinal vessels. Mech Dev. 2002 Jan; 110(1-2):183-6. PMID: 11744380.
    Citations: 18     Fields:    Translation:AnimalsCells
Local representatives can answer questions about the Profiles website or help with editing a profile or issues with profile data. For assistance with this profile: HMS/HSDM faculty should contact feedbackcatalyst.harvard.edu. For faculty or fellow appointment updates and changes, please ask your appointing department to contact HMS. For fellow personal and demographic information, contact HMS Human Resources at human_resourceshms.harvard.edu. For faculty personal and demographic information, contact HMS Office for Faculty Affairs at facappthms.harvard.edu.
Saint-Geniez's Networks
Click the
Explore
buttons for more information and interactive visualizations!
Concepts (265)
Explore
_
Co-Authors (26)
Explore
_
Similar People (60)
Explore
_
Same Department 
Explore
_
Physical Neighbors
_
Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.