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Magali Saint-Geniez, Ph.D.


The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. M2017138 (SAINT-GENIEZ, MAGALI) Jul 1, 2018 - Jun 30, 2020
    BrightFocus Foundation
    Investigating the role of PGC-1beta in neovascular AMD
    Role Description: This project aims to characterize the contribution of PGC-1b to neovascular AMD and to identify therapeutic methods for targeting pathway as therapy for advanced AMD.
    Role: PI
  2. ARI (SAINT-GENIEZ, MAGALI) Jul 1, 2017 - Jun 30, 2018
    Alcon Young Investigator Award
    Targeting RPE metabolism in AMD
    Role Description: This award supports on going research to elucidate fundamental questions on the contribution of metabolic alterations to RPE and photoreceptors’ oxidative stress and degeneration during AMD progression.
    Role: PI
  3. Special Scholars Award (SAINT-GENIEZ, MAGALI) Jul 1, 2015 - Jun 30, 2017
    Research to Prevent Blindness
    Energy failure and PGC-1 coactivators in photoreceptor degeneration following retinal detachment
    Role Description: This grant aimed to characterize the metabolic changes associated with retinal detachment.
    Role: PI
  4. R01EY023682 (ARANY, ZOLTAN P) Aug 1, 2013 - Jul 31, 2016
    PGC-1 coactivators in photoreceptor development and survival
    Role: Co-Principal Investigator
  5. M2013161 (SAINT-GENIEZ, MAGALI) Jul 1, 2013 - Jun 30, 2015
    BrightFocus Foundation
    Role of PGC-1 isoforms in RPE function and oxidative stress: implications for AMD
    Role Description: The goal of this study was to test the hypothesis that a new critical regulator of a cell’s metabolism and survival, called PGC-1, may play an essential role in the function of RPE cells and that they protect RPE cells from oxidative damage and degeneration.
    Role: PI

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Yoshie H, Koushki N, Kaviani R, Tabatabaei M, Rajendran K, Dang Q, Husain A, Yao S, Li C, Sullivan JK, Saint-Geniez M, Krishnan R, Ehrlicher AJ. Traction Force Screening Enabled by Compliant PDMS Elastomers. Biophys J. 2018 May 08; 114(9):2194-2199. PMID: 29742412.
    View in: PubMed
  2. Park-Windhol C, Ng YS, Yang J, Primo V, Saint-Geniez M, D'Amore PA. Endomucin inhibits VEGF-induced endothelial cell migration, growth, and morphogenesis by modulating VEGFR2 signaling. Sci Rep. 2017 Dec 07; 7(1):17138. PMID: 29215001.
    View in: PubMed
  3. Gerhardt MJ, Marsh JA, Morrison M, Kazlauskas A, Khadka A, Rosenkranz S, DeAngelis MM, Saint-Geniez M, Jacobo SMP. ER stress-induced aggresome trafficking of HtrA1 protects against proteotoxicity. J Mol Cell Biol. 2017 Dec 01; 9(6):533. PMID: 29040612.
    View in: PubMed
  4. Gerhardt MJ, Marsh JA, Morrison M, Kazlauskas A, Khadka A, Rosenkranz S, DeAngelis MM, Saint-Geniez M, Jacobo SMP. ER stress-induced aggresome trafficking of HtrA1 protects against proteotoxicity. J Mol Cell Biol. 2017 Dec 01; 9(6):516-532. PMID: 28992183.
    View in: PubMed
  5. Machuca-Parra AI, Bigger-Allen AA, Sanchez AV, Boutabla A, Cardona-Vélez J, Amarnani D, Saint-Geniez M, Siebel CW, Kim LA, D'Amore PA, Arboleda-Velasquez JF. Therapeutic antibody targeting of Notch3 signaling prevents mural cell loss in CADASIL. J Exp Med. 2017 Aug 07; 214(8):2271-2282. PMID: 28698285.
    View in: PubMed
  6. Saint-Geniez M, Rosales MAB. Eyeing the Fountain of Youth. Cell Stem Cell. 2017 05 04; 20(5):583-584. PMID: 28475881.
    View in: PubMed
  7. Spencer C, Abend S, McHugh KJ, Saint-Geniez M. Identification of a synergistic interaction between endothelial cells and retinal pigment epithelium. J Cell Mol Med. 2017 10; 21(10):2542-2552. PMID: 28402065.
    View in: PubMed
  8. Iacovelli J, Rowe GC, Khadka A, Diaz-Aguilar D, Spencer C, Arany Z, Saint-Geniez M. PGC-1a Induces Human RPE Oxidative Metabolism and Antioxidant Capacity. Invest Ophthalmol Vis Sci. 2016 Mar; 57(3):1038-51. PMID: 26962700; PMCID: PMC4788093.
  9. Zahr A, Alcaide P, Yang J, Jones A, Gregory M, dela Paz NG, Patel-Hett S, Nevers T, Koirala A, Luscinskas FW, Saint-Geniez M, Ksander B, D'Amore PA, Argüeso P. Endomucin prevents leukocyte-endothelial cell adhesion and has a critical role under resting and inflammatory conditions. Nat Commun. 2016 Feb 02; 7:10363. PMID: 26831939; PMCID: PMC4740757.
  10. Sánchez-Palencia DM, Bigger-Allen A, Saint-Geniez M, Arboleda-Velásquez JF, D'Amore PA. Coculture Assays for Endothelial Cells-Mural Cells Interactions. Methods Mol Biol. 2016; 1464:35-47. PMID: 27858354.
    View in: PubMed
  11. Kim C, Smith KE, Castillejos A, Diaz-Aguilar D, Saint-Geniez M, Connor KM. The alternative complement pathway aids in vascular regression during the early stages of a murine model of proliferative retinopathy. FASEB J. 2016 Mar; 30(3):1300-5. PMID: 26631482; PMCID: PMC4750413.
  12. Saint-Geniez M, Ghelfi E, Liang X, Yu C, Spencer C, Abend S, Hotamisligil G, Cataltepe S. Fatty acid binding protein 4 deficiency protects against oxygen-induced retinopathy in mice. PLoS One. 2014; 9(5):e96253. PMID: 24802082; PMCID: PMC4011730.
  13. Wang J, Iacovelli J, Spencer C, Saint-Geniez M. Direct effect of sodium iodate on neurosensory retina. Invest Ophthalmol Vis Sci. 2014 Mar 28; 55(3):1941-53. PMID: 24481259; PMCID: PMC4049579.
  14. McHugh KJ, Tao SL, Saint-Geniez M. Porous poly(e-caprolactone) scaffolds for retinal pigment epithelium transplantation. Invest Ophthalmol Vis Sci. 2014 Mar 25; 55(3):1754-62. PMID: 24550370; PMCID: PMC3968933.
  15. Sweigard JH, Yanai R, Gaissert P, Saint-Geniez M, Kataoka K, Thanos A, Stahl GL, Lambris JD, Connor KM. The alternative complement pathway regulates pathological angiogenesis in the retina. FASEB J. 2014 Jul; 28(7):3171-82. PMID: 24668752; PMCID: PMC4062823.
  16. McHugh KJ, Saint-Geniez M, Tao SL. Topographical control of ocular cell types for tissue engineering. J Biomed Mater Res B Appl Biomater. 2013 Nov; 101(8):1571-84. PMID: 23744715; PMCID: PMC4090092.
  17. McHugh KJ, Tao SL, Saint-Geniez M. A novel porous scaffold fabrication technique for epithelial and endothelial tissue engineering. J Mater Sci Mater Med. 2013 Jul; 24(7):1659-70. PMID: 23625319; PMCID: PMC4086292.
  18. Ford KM, Saint-Geniez M, Walshe TE, D'Amore PA. Expression and role of VEGF--a in the ciliary body. Invest Ophthalmol Vis Sci. 2012 Nov 07; 53(12):7520-7. PMID: 23081980; PMCID: PMC3493183.
  19. Saint-Geniez M, Jiang A, Abend S, Liu L, Sweigard H, Connor KM, Arany Z. PGC-1a regulates normal and pathological angiogenesis in the retina. Am J Pathol. 2013 Jan; 182(1):255-65. PMID: 23141926; PMCID: PMC3538026.
  20. dela Paz NG, Walshe TE, Leach LL, Saint-Geniez M, D'Amore PA. Role of shear-stress-induced VEGF expression in endothelial cell survival. J Cell Sci. 2012 Feb 15; 125(Pt 4):831-43. PMID: 22399811; PMCID: PMC3311927.
  21. Ford KM, Saint-Geniez M, Walshe T, Zahr A, D'Amore PA. Expression and role of VEGF in the adult retinal pigment epithelium. Invest Ophthalmol Vis Sci. 2011 Dec 09; 52(13):9478-87. PMID: 22058334; PMCID: PMC3250352.
  22. Sekiyama E, Saint-Geniez M, Yoneda K, Hisatomi T, Nakao S, Walshe TE, Maruyama K, Hafezi-Moghadam A, Miller JW, Kinoshita S, D'Amore PA. Heat treatment of retinal pigment epithelium induces production of elastic lamina components and antiangiogenic activity. FASEB J. 2012 Feb; 26(2):567-75. PMID: 22067481; PMCID: PMC4090388.
  23. Darland DC, Cain JT, Berosik MA, Saint-Geniez M, Odens PW, Schaubhut GJ, Frisch S, Stemmer-Rachamimov A, Darland T, D'Amore PA. Vascular endothelial growth factor (VEGF) isoform regulation of early forebrain development. Dev Biol. 2011 Oct 01; 358(1):9-22. PMID: 21803034; PMCID: PMC3189089.
  24. Bryan BA, Dennstedt E, Mitchell DC, Walshe TE, Noma K, Loureiro R, Saint-Geniez M, Campaigniac JP, Liao JK, D'Amore PA. RhoA/ROCK signaling is essential for multiple aspects of VEGF-mediated angiogenesis. FASEB J. 2010 Sep; 24(9):3186-95. PMID: 20400538; PMCID: PMC2923346.
  25. Saint-Geniez M, Kurihara T, Sekiyama E, Maldonado AE, D'Amore PA. An essential role for RPE-derived soluble VEGF in the maintenance of the choriocapillaris. Proc Natl Acad Sci U S A. 2009 Nov 03; 106(44):18751-6. PMID: 19841260; PMCID: PMC2774033.
  26. Walshe TE, Saint-Geniez M, Maharaj AS, Sekiyama E, Maldonado AE, D'Amore PA. TGF-beta is required for vascular barrier function, endothelial survival and homeostasis of the adult microvasculature. PLoS One. 2009; 4(4):e5149. PMID: 19340291; PMCID: PMC2659748.
  27. Saint-Geniez M, Maharaj AS, Walshe TE, Tucker BA, Sekiyama E, Kurihara T, Darland DC, Young MJ, D'Amore PA. Endogenous VEGF is required for visual function: evidence for a survival role on müller cells and photoreceptors. PLoS One. 2008; 3(11):e3554. PMID: 18978936; PMCID: PMC2571983.
  28. Saint-Geniez M, Kurihara T, D'Amore PA. Role of cell and matrix-bound VEGF isoforms in lens development. Invest Ophthalmol Vis Sci. 2009 Jan; 50(1):311-21. PMID: 18757513.
    View in: PubMed
  29. Maharaj AS, Walshe TE, Saint-Geniez M, Venkatesha S, Maldonado AE, Himes NC, Matharu KS, Karumanchi SA, D'Amore PA. VEGF and TGF-beta are required for the maintenance of the choroid plexus and ependyma. J Exp Med. 2008 Feb 18; 205(2):491-501. PMID: 18268040; PMCID: PMC2271023.
  30. Bryan BA, Walshe TE, Mitchell DC, Havumaki JS, Saint-Geniez M, Maharaj AS, Maldonado AE, D'Amore PA. Coordinated vascular endothelial growth factor expression and signaling during skeletal myogenic differentiation. Mol Biol Cell. 2008 Mar; 19(3):994-1006. PMID: 18094043.
    View in: PubMed
  31. Cursiefen C, Chen L, Saint-Geniez M, Hamrah P, Jin Y, Rashid S, Pytowski B, Persaud K, Wu Y, Streilein JW, Dana R. Nonvascular VEGF receptor 3 expression by corneal epithelium maintains avascularity and vision. Proc Natl Acad Sci U S A. 2006 Jul 25; 103(30):11405-10. PMID: 16849433; PMCID: PMC1544098.
  32. Saint-Geniez M, Maldonado AE, D'Amore PA. VEGF expression and receptor activation in the choroid during development and in the adult. Invest Ophthalmol Vis Sci. 2006 Jul; 47(7):3135-42. PMID: 16799060.
    View in: PubMed
  33. Lutty GA, Chan-Ling T, Phelps DL, Adamis AP, Berns KI, Chan CK, Cole CH, D'Amore PA, Das A, Deng WT, Dobson V, Flynn JT, Friedlander M, Fulton A, Good WV, Grant MB, Hansen R, Hauswirth WW, Hardy RJ, Hinton DR, Hughes S, McLeod DS, Palmer EA, Patz A, Penn JS, Raisler BJ, Repka MX, Saint-Geniez M, Shaw LC, Shima DT, Smith BT, Smith LE, Tahija SG, Tasman W, Trese MT. Proceedings of the Third International Symposium on Retinopathy of Prematurity: an update on ROP from the lab to the nursery (November 2003, Anaheim, California). Mol Vis. 2006 May 23; 12:532-80. PMID: 16735995.
    View in: PubMed
  34. Maharaj AS, Saint-Geniez M, Maldonado AE, D'Amore PA. Vascular endothelial growth factor localization in the adult. Am J Pathol. 2006 Feb; 168(2):639-48. PMID: 16436677; PMCID: PMC1606504.
  35. Saint-Geniez M, D'Amore PA. Development and pathology of the hyaloid, choroidal and retinal vasculature. Int J Dev Biol. 2004; 48(8-9):1045-58. PMID: 15558494.
    View in: PubMed
  36. Darland DC, Massingham LJ, Smith SR, Piek E, Saint-Geniez M, D'Amore PA. Pericyte production of cell-associated VEGF is differentiation-dependent and is associated with endothelial survival. Dev Biol. 2003 Dec 01; 264(1):275-88. PMID: 14623248.
    View in: PubMed
  37. Le Gat L, Gogat K, Bouquet C, Saint-Geniez M, Darland D, Van Den Berghe L, Marchant D, Provost A, Perricaudet M, Menasche M, Abitbol M. In vivo adenovirus-mediated delivery of a uPA/uPAR antagonist reduces retinal neovascularization in a mouse model of retinopathy. Gene Ther. 2003 Dec; 10(25):2098-103. PMID: 14595383.
    View in: PubMed
  38. Saint-Geniez M, Argence CB, Knibiehler B, Audigier Y. The msr/apj gene encoding the apelin receptor is an early and specific marker of the venous phenotype in the retinal vasculature. Gene Expr Patterns. 2003 Aug; 3(4):467-72. PMID: 12915314.
    View in: PubMed
  39. Saint-Geniez M, Masri B, Malecaze F, Knibiehler B, Audigier Y. Expression of the murine msr/apj receptor and its ligand apelin is upregulated during formation of the retinal vessels. Mech Dev. 2002 Jan; 110(1-2):183-6. PMID: 11744380.
    View in: PubMed
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Funded by the NIH/NCATS Clinical and Translational Science Award (CTSA) program, grant number UL1TR001102, and through institutional support from Harvard University, Harvard Medical School, Harvard T.H. Chan School of Public Health, Beth Israel Deaconess Medical Center, Boston Children's Hospital, Brigham and Women's Hospital, Massachusetts General Hospital and the Dana Farber Cancer Institute.