Duane Wesemann, M.D., Ph.D.
Title Associate Professor of Medicine Institution Brigham and Women's Hospital Address Hale Building for Transformative Medicine
Room 5002 O
60 Fenwood Rd
Boston MA 02115
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Biography
2008 - 2008
Outstanding Fellow Award for excellence in teaching
2009 - 2010
AAAAI-GSK Career Development Award
2010 - 2011
AAAAI-Baxter Career Development Award
2011 - 2013
Young Investigator Award in Primary Immune Deficiency
2011 - 2016
Burroughs Wellcome Career Award for Medical Scientists
2013 - 2015
Young Investigator Award in Mucosal Immunity
2015 - 2017
FARE New Investigator Award
2015
Sir William Osler Young Investigator Award
Overview
A diverse repertoire of immunoglobulins (antibodies) is required to build effective immunity against a vast array of infectious threats. However, expanded immunoglobulin diversity raises the risk of generating antibodies directed against self or otherwise innocuous environmental components, which can lead to autoimmune and allergic disorders, respectively. Our lab studies the process of primary immunoglobulin repertoire diversification and how environmental factors, such as commensal microbes and diet, may influence the structure and depth of this diversity. We are particularly interested in how exposures early in life may shape this process. As we work to identify principles regulating the host:environment interactions that modulate the immune system, we seek to deepen our understanding of how this may impact the development of immunity to infection and efficacy of vaccination. In addition, we are undertaking innovative approaches to uncover therapeutic targets for the treatment of allergic disorders such as food allergies and asthma. Please visit the
wesemann lab website.
Mentoring
Available: 10/26/20, Expires: 10/31/25
The Wesemann laboratory, located in the longwood medical area, uses mouse genetics, human studies, cellular biology, single cell transcriptomics, and computation to elucidate the underlying features and elasticity of antibody recognition capacity. We study the dynamic regulation, functional significance, and evolutionary implications/origins of the anticipatory naïve antibody repertoire and its somatically evolving counterpart in germinal centers. Both bench-side as well as computational opportunities are available for students to complete scholarly projects on deciphering features connected to the type and quality of antibody responses.
Current projects include longitudinal analysis of immune responses to SARS-CoV-2 infection as well as responses to COVID-19 vaccines in plasma and cell samples collected by and stored in the Wesemann lab. Bench projects will require some experience with pipetting, ELISAs, cell culture, PCR, and flow cytometry. Computational projects will require some familiarity processing data through tools available at the National Center for Biotechnology Information and the Protein Data Bank with code writing experience in languages such as R. Both in-person and remote projects are available. Both short (4-6 month) and long-term (greater than 6 months) projects are available.
Research
The research activities and funding listed below are automatically derived from
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R01AI169619
(WESEMANN, DUANE R.)
Sep 17, 2021 - Aug 31, 2026
Role: Principal Investigator
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P01AI165072
(WESEMANN, DUANE R.)
Sep 16, 2021 - Aug 31, 2024
Discovering Durable Pan-Coronavirus Immunity
Role: Principal Investigator
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R56AI158811
(WESEMANN, DUANE R.)
Jul 1, 2021 - Jun 30, 2022
Understanding IgE Biology
Role: Principal Investigator
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R01AI139538
(WESEMANN, DUANE R.)
Mar 20, 2019 - Feb 28, 2023
Elucidating Germinal Center-Mediated Antibody Evolution
Role: Principal Investigator
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R21AI137940
(WESEMANN, DUANE R.)
May 22, 2018 - Apr 30, 2021
Exploring the Role of IgA in Human Immune Homeostasis
Role: Principal Investigator
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R01AI121394
(WESEMANN, DUANE R.)
Dec 1, 2015 - Nov 30, 2020
Decrypting IgE B Cell Immunobiology
Role: Principal Investigator
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R01AI113217
(WESEMANN, DUANE R.)
Dec 1, 2014 - Nov 30, 2019
Discovering the Role of Commensal Microbes on Primary B Lymphocyte Development
Role: Principal Investigator
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R56AI113217
(WESEMANN, DUANE R.)
Aug 1, 2014 - Nov 30, 2014
Discovering the Role of Commensal Microbes on Primary B Lymphocyte Development
Role: Principal Investigator
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K08AI089972
(WESEMANN, DUANE R.)
Jul 1, 2010 - Jun 30, 2015
Peripheral B Cell Receptor Editing
Role: Principal Investigator
Bibliographic
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