Harvard Catalyst Profiles

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Duane Wesemann, M.D., Ph.D.

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2008 - 2008
Outstanding Fellow Award for excellence in teaching
2009 - 2010
AAAAI-GSK Career Development Award
2010 - 2011
AAAAI-Baxter Career Development Award
2011 - 2013
Young Investigator Award in Primary Immune Deficiency
2011 - 2016
Burroughs Wellcome Career Award for Medical Scientists
2013 - 2015
Young Investigator Award in Mucosal Immunity
2015 - 2017
FARE New Investigator Award
Sir William Osler Young Investigator Award

A diverse repertoire of immunoglobulins (antibodies) is required to build effective immunity against a vast array of infectious threats. However, expanded immunoglobulin diversity raises the risk of generating antibodies directed against self or otherwise innocuous environmental components, which can lead to autoimmune and allergic disorders, respectively. Our lab studies the process of primary immunoglobulin repertoire diversification and how environmental factors, such as commensal microbes and diet, may influence the structure and depth of this diversity. We are particularly interested in how exposures early in life may shape this process. As we work to identify principles regulating the host:environment interactions that modulate the immune system, we seek to deepen our understanding of how this may impact the development of immunity to infection and efficacy of vaccination. In addition, we are undertaking innovative approaches to uncover therapeutic targets for the treatment of allergic disorders such as food allergies and asthma. Please visit the wesemann lab website.

Available: 10/26/20, Expires: 10/31/25

The Wesemann laboratory, located in the longwood medical area, uses mouse genetics, human studies, cellular biology, single cell transcriptomics, and computation to elucidate the underlying features and elasticity of antibody recognition capacity. We study the dynamic regulation, functional significance, and evolutionary implications/origins of the anticipatory naïve antibody repertoire and its somatically evolving counterpart in germinal centers. Both bench-side as well as computational opportunities are available for students to complete scholarly projects on deciphering features connected to the type and quality of antibody responses.

Current projects include longitudinal analysis of immune responses to SARS-CoV-2 infection as well as responses to COVID-19 vaccines in plasma and cell samples collected by and stored in the Wesemann lab. Bench projects will require some experience with pipetting, ELISAs, cell culture, PCR, and flow cytometry. Computational projects will require some familiarity processing data through tools available at the National Center for Biotechnology Information and the Protein Data Bank with code writing experience in languages such as R. Both in-person and remote projects are available. Both short (4-6 month) and long-term (greater than 6 months) projects are available.

The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01AI169619 (WESEMANN, DUANE R.) Sep 17, 2021 - Aug 31, 2026
    Flipped Germinal Centers
    Role: Principal Investigator
  2. P01AI165072 (WESEMANN, DUANE R.) Sep 16, 2021 - Aug 31, 2024
    Discovering Durable Pan-Coronavirus Immunity
    Role: Principal Investigator
  3. R56AI158811 (WESEMANN, DUANE R.) Jul 1, 2021 - Jun 30, 2022
    Understanding IgE Biology
    Role: Principal Investigator
  4. R01AI139538 (WESEMANN, DUANE R.) Mar 20, 2019 - Feb 28, 2023
    Elucidating Germinal Center-Mediated Antibody Evolution
    Role: Principal Investigator
  5. R21AI137940 (WESEMANN, DUANE R.) May 22, 2018 - Apr 30, 2021
    Exploring the Role of IgA in Human Immune Homeostasis
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Bruno PM, Timms RT, Abdelfattah NS, Leng Y, Lelis FJN, Wesemann DR, Yu XG, Elledge SJ. High-throughput, targeted MHC class I immunopeptidomics using a functional genetics screening platform. Nat Biotechnol. 2023 Jan 02. PMID: 36593401.
    Citations:    Fields:    
  2. Chen Y, Tong P, Whiteman N, Sanjari Moghaddam A, Zarghami M, Zuiani A, Habibi S, Gautam A, Bi C, Xiao T, Cai Y, Chen B, Neuberg D, Wesemann DR. Immune recall improves antibody durability and breadth to SARS-CoV-2 variants. Sci Immunol. 2022 12 23; 7(78):eabp8328. PMID: 35549298; PMCID: PMC9097880.
    Citations:    Fields:    
  3. Rahman RS, Wesemann DR. Immunology of allergen immunotherapy. Immunother Adv. 2022; 2(1):ltac022. PMID: 36530352; PMCID: PMC9749131.
  4. Windsor IW, Tong P, Lavidor O, Moghaddam AS, McKay LGA, Gautam A, Chen Y, MacDonald EA, Yoo DK, Griffths A, Wesemann DR, Harrison SC. Antibodies induced by an ancestral SARS-CoV-2 strain that cross-neutralize variants from Alpha to Omicron BA.1. Sci Immunol. 2022 08 12; 7(74):eabo3425. PMID: 35536154; PMCID: PMC9097876.
    Citations: 1     Fields:    
  5. Nelson RW, Chen Y, Venezia OL, Majerus RM, Shin DS, Carrington MN, Yu XG, Wesemann DR, Moon JJ, Luster AD. SARS-CoV-2 epitope-specific CD4+ memory T cell responses across COVID-19 disease severity and antibody durability. Sci Immunol. 2022 07 22; 7(73):eabl9464. PMID: 35857584; PMCID: PMC9097883.
    Citations:    Fields:    Translation:HumansCells
  6. Banday AR, Stanifer ML, Florez-Vargas O, Onabajo OO, Papenberg BW, Zahoor MA, Mirabello L, Ring TJ, Lee CH, Albert PS, Andreakos E, Arons E, Barsh G, Biesecker LG, Boyle DL, Brahier MS, Burnett-Hartman A, Carrington M, Chang E, Choe PG, Chisholm RL, Colli LM, Dalgard CL, Dude CM, Edberg J, Erdmann N, Feigelson HS, Fonseca BA, Firestein GS, Gehring AJ, Guo C, Ho M, Holland S, Hutchinson AA, Im H, Irby L, Ison MG, Joseph NT, Kim HB, Kreitman RJ, Korf BR, Lipkin SM, Mahgoub SM, Mohammed I, Paschoalini GL, Pacheco JA, Peluso MJ, Rader DJ, Redden DT, Ritchie MD, Rosenblum B, Ross ME, Anna HPS, Savage SA, Sharma S, Siouti E, Smith AK, Triantafyllia V, Vargas JM, Vargas JD, Verma A, Vij V, Wesemann DR, Yeager M, Yu X, Zhang Y, Boulant S, Chanock SJ, Feld JJ, Prokunina-Olsson L. Genetic regulation of OAS1 nonsense-mediated decay underlies association with COVID-19 hospitalization in patients of European and African ancestries. Nat Genet. 2022 08; 54(8):1103-1116. PMID: 35835913; PMCID: PMC9355882.
    Citations:    Fields:    
  7. Zhang J, Tang W, Gao H, Lavine CL, Shi W, Peng H, Zhu H, Anand K, Kosikova M, Kwon HJ, Tong P, Gautam A, Rits-Volloch S, Wang S, Mayer ML, Wesemann DR, Seaman MS, Lu J, Xiao T, Xie H, Chen B. Structural and functional characteristics of SARS-CoV-2 Omicron subvariant BA.2 spike. bioRxiv. 2022 Apr 28. PMID: 35547850; PMCID: PMC9094093.
  8. Zhang J, Cai Y, Lavine CL, Peng H, Zhu H, Anand K, Tong P, Gautam A, Mayer ML, Rits-Volloch S, Wang S, Sliz P, Wesemann DR, Yang W, Seaman MS, Lu J, Xiao T, Chen B. Structural and functional impact by SARS-CoV-2 Omicron spike mutations. Cell Rep. 2022 04 26; 39(4):110729. PMID: 35452593; PMCID: PMC8995406.
    Citations: 12     Fields:    Translation:HumansCells
  9. Wesemann DR. Omicron's message on vaccines: Boosting begets breadth. Cell. 2022 02 03; 185(3):411-413. PMID: 35065712; PMCID: PMC8758338.
    Citations: 4     Fields:    Translation:HumansCells
  10. Zuiani A, Wesemann DR. Antibody Dynamics and Durability in Coronavirus Disease-19. Clin Lab Med. 2022 03; 42(1):85-96. PMID: 35153050; PMCID: PMC8563365.
    Citations:    Fields:    Translation:HumansCells
  11. Zhang J, Xiao T, Cai Y, Lavine CL, Peng H, Zhu H, Anand K, Tong P, Gautam A, Mayer ML, Walsh RM, Rits-Volloch S, Wesemann DR, Yang W, Seaman MS, Lu J, Chen B. Membrane fusion and immune evasion by the spike protein of SARS-CoV-2 Delta variant. Science. 2021 Dec 10; 374(6573):1353-1360. PMID: 34698504.
    Citations: 69     Fields:    Translation:HumansCells
  12. Zhang J, Xiao T, Cai Y, Lavine CL, Peng H, Zhu H, Anand K, Tong P, Gautam A, Mayer ML, Walsh RM, Rits-Volloch S, Wesemann DR, Yang W, Seaman MS, Lu J, Chen B. Membrane fusion and immune evasion by the spike protein of SARS-CoV-2 Delta variant. bioRxiv. 2021 Aug 17. PMID: 34426810; PMCID: PMC8382121.
  13. Tong P, Gautam A, Windsor IW, Travers M, Chen Y, Garcia N, Whiteman NB, McKay LGA, Storm N, Malsick LE, Honko AN, Lelis FJN, Habibi S, Jenni S, Cai Y, Rennick LJ, Duprex WP, McCarthy KR, Lavine CL, Zuo T, Lin J, Zuiani A, Feldman J, MacDonald EA, Hauser BM, Griffths A, Seaman MS, Schmidt AG, Chen B, Neuberg D, Bajic G, Harrison SC, Wesemann DR. Memory B cell repertoire for recognition of evolving SARS-CoV-2 spike. Cell. 2021 09 16; 184(19):4969-4980.e15. PMID: 34332650; PMCID: PMC8299219.
    Citations: 31     Fields:    
  14. Banday AR, Stanifer ML, Florez-Vargas O, Onabajo OO, Zahoor MA, Papenberg BW, Ring TJ, Lee CH, Andreakos E, Arons E, Barsh G, Biesecker LG, Boyle DL, Burnett-Hartman A, Carrington M, Chang E, Choe PG, Chrisholm RL, Dalgard C, Edberg J, Erdmann N, Feigelson HS, Firestein GS, Gehring AJ, Ho M, Holland S, Hutchinson AA, Im H, Ison MG, Kim HB, Kreitman RJ, Korf BR, Mirabello L, Pacheco JA, Peluso MJ, Rader DJ, Redden DT, Ritchie MD, Rosenbloom B, Sant Anna HP, Savage S, Siouti E, Triantafyllia V, Vargas JM, Verma A, Vij V, Wesemann DR, Yeager M, Yu X, Zhang Y, Boulant S, Chanock SJ, Feld JJ, Prokunina-Olsson L. Genetic regulation of OAS1 nonsense-mediated decay underlies association with risk of severe COVID-19. medRxiv. 2021 Jul 13. PMID: 34282422; PMCID: PMC8288155.
  15. Cai Y, Zhang J, Xiao T, Lavine CL, Rawson S, Peng H, Zhu H, Anand K, Tong P, Gautam A, Lu S, Sterling SM, Walsh RM, Rits-Volloch S, Lu J, Wesemann DR, Yang W, Seaman MS, Chen B. Structural basis for enhanced infectivity and immune evasion of SARS-CoV-2 variants. Science. 2021 08 06; 373(6555):642-648. PMID: 34168070; PMCID: PMC9245151.
    Citations: 70     Fields:    Translation:HumansCells
  16. Cai Y, Zhang J, Xiao T, Lavine CL, Rawson S, Peng H, Zhu H, Anand K, Tong P, Gautam A, Lu S, Sterling SM, Walsh RM, Rits-Volloch S, Lu J, Wesemann DR, Yang W, Seaman MS, Chen B. Structural basis for enhanced infectivity and immune evasion of SARS-CoV-2 variants. bioRxiv. 2021 Apr 14. PMID: 33880477; PMCID: PMC8057242.
  17. Tong P, Gautam A, Windsor I, Travers M, Chen Y, Garcia N, Whiteman NB, McKay LGA, Lelis FJN, Habibi S, Cai Y, Rennick LJ, Duprex WP, McCarthy KR, Lavine CL, Zuo T, Lin J, Zuiani A, Feldman J, MacDonald EA, Hauser BM, Griffths A, Seaman MS, Schmidt AG, Chen B, Neuberg D, Bajic G, Harrison SC, Wesemann DR. Memory B cell repertoire for recognition of evolving SARS-CoV-2 spike. bioRxiv. 2021 Mar 10. PMID: 33758863; PMCID: PMC7987022.
  18. Atyeo C, Slein MD, Fischinger S, Burke J, Schäfer A, Leist SR, Kuzmina NA, Mire C, Honko A, Johnson R, Storm N, Bernett M, Tong P, Zuo T, Lin J, Zuiani A, Linde C, Suscovich T, Wesemann DR, Griffiths A, Desjarlais JR, Juelg BD, Goudsmit J, Bukreyev A, Baric R, Alter G. Dissecting strategies to tune the therapeutic potential of SARS-CoV-2-specific monoclonal antibody CR3022. JCI Insight. 2021 01 11; 6(1). PMID: 33427208.
    Citations: 19     Fields:    Translation:HumansAnimalsCells
  19. Chen Y, Zuiani A, Fischinger S, Mullur J, Atyeo C, Travers M, Lelis FJN, Pullen KM, Martin H, Tong P, Gautam A, Habibi S, Bensko J, Gakpo D, Feldman J, Hauser BM, Caradonna TM, Cai Y, Burke JS, Lin J, Lederer JA, Lam EC, Lavine CL, Seaman MS, Chen B, Schmidt AG, Balazs AB, Lauffenburger DA, Alter G, Wesemann DR. Quick COVID-19 Healers Sustain Anti-SARS-CoV-2 Antibody Production. Cell. 2020 12 10; 183(6):1496-1507.e16. PMID: 33171099.
    Citations: 93     Fields:    Translation:HumansCells
  20. Shrock E, Fujimura E, Kula T, Timms RT, Lee IH, Leng Y, Robinson ML, Sie BM, Li MZ, Chen Y, Logue J, Zuiani A, McCulloch D, Lelis FJN, Henson S, Monaco DR, Travers M, Habibi S, Clarke WA, Caturegli P, Laeyendecker O, Piechocka-Trocha A, Li JZ, Khatri A, Chu HY, Villani AC, Kays K, Goldberg MB, Hacohen N, Filbin MR, Yu XG, Walker BD, Wesemann DR, Larman HB, Lederer JA, Elledge SJ. Viral epitope profiling of COVID-19 patients reveals cross-reactivity and correlates of severity. Science. 2020 11 27; 370(6520). PMID: 32994364; PMCID: PMC7857405.
    Citations: 204     Fields:    Translation:HumansCells
  21. Johnson JA, Pearson JC, Kubiak DW, Dionne B, Little SE, Wesemann DR. Treatment of Chronic Granulomatous Disease-Related Pulmonary Aspergillus Infection in Late Pregnancy. Open Forum Infect Dis. 2020 Oct; 7(10):ofaa447. PMID: 33134418.
  22. Roy V, Fischinger S, Atyeo C, Slein M, Loos C, Balazs A, Luedemann C, Astudillo MG, Yang D, Wesemann DR, Charles R, Lafrate AJ, Feldman J, Hauser B, Caradonna T, Miller TE, Murali MR, Baden L, Nilles E, Ryan E, Lauffenburger D, Beltran WG, Alter G. SARS-CoV-2-specific ELISA development. J Immunol Methods. 2020 Sep - Oct; 484-485:112832. PMID: 32780998.
    Citations: 36     Fields:    Translation:HumansCellsPHPublic Health
  23. Yu J, Tostanoski LH, Peter L, Mercado NB, McMahan K, Mahrokhian SH, Nkolola JP, Liu J, Li Z, Chandrashekar A, Martinez DR, Loos C, Atyeo C, Fischinger S, Burke JS, Slein MD, Chen Y, Zuiani A, Lelis FJN, Travers M, Habibi S, Pessaint L, Van Ry A, Blade K, Brown R, Cook A, Finneyfrock B, Dodson A, Teow E, Velasco J, Zahn R, Wegmann F, Bondzie EA, Dagotto G, Gebre MS, He X, Jacob-Dolan C, Kirilova M, Kordana N, Lin Z, Maxfield LF, Nampanya F, Nityanandam R, Ventura JD, Wan H, Cai Y, Chen B, Schmidt AG, Wesemann DR, Baric RS, Alter G, Andersen H, Lewis MG, Barouch DH. DNA vaccine protection against SARS-CoV-2 in rhesus macaques. Science. 2020 08 14; 369(6505):806-811. PMID: 32434945.
    Citations: 510     Fields:    Translation:HumansAnimalsCellsPHPublic Health
  24. Wesemann DR, Nagler CR. Origins of peanut allergy-causing antibodies. Science. 2020 03 06; 367(6482):1072-1073. PMID: 32139528.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  25. Wesemann DR. Game of clones: How measles remodels the B cell landscape. Sci Immunol. 2019 11 01; 4(41). PMID: 31672863.
    Citations: 1     Fields:    Translation:HumansCells
  26. Ng J, Wright K, Alvarez M, Hunninghake GM, Wesemann DR. Rituximab Monotherapy for Common Variable Immune Deficiency-Associated Granulomatous-Lymphocytic Interstitial Lung Disease. Chest. 2019 05; 155(5):e117-e121. PMID: 31060706; PMCID: PMC6689079.
    Citations: 12     Fields:    Translation:HumansCells
  27. Zuo T, Gautam A, Wesemann DR. Affinity war: forging immunoglobulin repertoires. Curr Opin Immunol. 2019 04; 57:32-39. PMID: 30690255; PMCID: PMC6511487.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  28. Gansner JM, Rahmani M, Jonsson AH, Fortin BM, Brimah I, Ellis M, Smeland-Wagman R, Li ZJ, Schenkel JM, Brenner MB, Yefidoff-Freedman R, Sloan SR, Berliner N, Issa NC, Baden LR, Longo DL, Wesemann DR, Neuberg D, Rao DA, Kaufman RM. Plateletpheresis-associated lymphopenia in frequent platelet donors. Blood. 2019 02 07; 133(6):605-614. PMID: 30429159; PMCID: PMC6367645.
    Citations: 3     Fields:    Translation:HumansCells
  29. Chen Y, Chaudhary N, Yang N, Granato A, Turner JA, Howard SL, Devereaux C, Zuo T, Shrestha A, Goel RR, Neuberg D, Wesemann DR. Microbial symbionts regulate the primary Ig repertoire. J Exp Med. 2018 05 07; 215(5):1397-1415. PMID: 29588346; PMCID: PMC5940265.
    Citations: 24     Fields:    Translation:AnimalsCells
  30. Silver JN, Ashbaugh CD, Miles JJ, Wu H, Marecki GT, Hwang JK, Jiao JA, Abrams M, Sullivan EJ, Wesemann DR. Deployment of Transchromosomal Bovine for Personalized Antimicrobial Therapy. Clin Infect Dis. 2018 03 19; 66(7):1116-1119. PMID: 29272362.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  31. Chaudhary N, Wesemann DR. Analyzing Immunoglobulin Repertoires. Front Immunol. 2018; 9:462. PMID: 29593723.
    Citations: 31     Fields:    Translation:HumansAnimals
  32. Silver J, Zuo T, Chaudhary N, Kumari R, Tong P, Giguere S, Granato A, Donthula R, Devereaux C, Wesemann DR. Stochasticity enables BCR-independent germinal center initiation and antibody affinity maturation. J Exp Med. 2018 01 02; 215(1):77-90. PMID: 29247044; PMCID: PMC5748855.
    Citations: 13     Fields:    Translation:AnimalsCells
  33. Renz H, Adkins BD, Bartfeld S, Blumberg RS, Farber DL, Garssen J, Ghazal P, Hackam DJ, Marsland BJ, McCoy KD, Penders J, Prinz I, Verhasselt V, von Mutius E, Weiser JN, Wesemann DR, Hornef MW. The neonatal window of opportunity-early priming for life. J Allergy Clin Immunol. 2018 04; 141(4):1212-1214. PMID: 29247715.
    Citations: 27     Fields:    Translation:HumansPHPublic Health
  34. Tong P, Granato A, Zuo T, Chaudhary N, Zuiani A, Han SS, Donthula R, Shrestha A, Sen D, Magee JM, Gallagher MP, van der Poel CE, Carroll MC, Wesemann DR. IgH isotype-specific B cell receptor expression influences B cell fate. Proc Natl Acad Sci U S A. 2017 10 03; 114(40):E8411-E8420. PMID: 28923960; PMCID: PMC5635877.
    Citations: 9     Fields:    Translation:AnimalsCells
  35. Gosmann C, Anahtar MN, Handley SA, Farcasanu M, Abu-Ali G, Bowman BA, Padavattan N, Desai C, Droit L, Moodley A, Dong M, Chen Y, Ismail N, Ndung'u T, Ghebremichael MS, Wesemann DR, Mitchell C, Dong KL, Huttenhower C, Walker BD, Virgin HW, Kwon DS. Lactobacillus-Deficient Cervicovaginal Bacterial Communities Are Associated with Increased HIV Acquisition in Young South African Women. Immunity. 2017 01 17; 46(1):29-37. PMID: 28087240.
    Citations: 245     Fields:    Translation:HumansAnimalsCells
  36. Wesemann DR, Nagler CR. The Microbiome, Timing, and Barrier Function in the Context of Allergic Disease. Immunity. 2016 Apr 19; 44(4):728-38. PMID: 27096316.
    Citations: 47     Fields:    Translation:HumansCells
  37. Sloane D, Govindarajulu U, Harrow-Mortelliti J, Barry W, Hsu FI, Hong D, Laidlaw T, Palis R, Legere H, Bunyavanich S, Breslow R, Wesemann D, Barrett N, Brennan P, Chong HJ, Liu A, Fernandez J, Fanning L, Kyin T, Cahill K, Bankova L, Lynch A, Berlin S, Campos S, Fuchs C, Mayer R, Matulonis U, Castells M. Safety, Costs, and Efficacy of Rapid Drug Desensitizations to Chemotherapy and Monoclonal Antibodies. J Allergy Clin Immunol Pract. 2016 May-Jun; 4(3):497-504. PMID: 26895621.
    Citations: 37     Fields:    Translation:Humans
  38. Inci F, Filippini C, Baday M, Ozen MO, Calamak S, Durmus NG, Wang S, Hanhauser E, Hobbs KS, Juillard F, Kuang PP, Vetter ML, Carocci M, Yamamoto HS, Takagi Y, Yildiz UH, Akin D, Wesemann DR, Singhal A, Yang PL, Nibert ML, Fichorova RN, Lau DT, Henrich TJ, Kaye KM, Schachter SC, Kuritzkes DR, Steinmetz LM, Gambhir SS, Davis RW, Demirci U. Multitarget, quantitative nanoplasmonic electrical field-enhanced resonating device (NE2RD) for diagnostics. Proc Natl Acad Sci U S A. 2015 Aug 11; 112(32):E4354-63. PMID: 26195743; PMCID: PMC4538635.
    Citations: 20     Fields:    Translation:HumansCells
  39. Granato A, Chen Y, Wesemann DR. Primary immunoglobulin repertoire development: time and space matter. Curr Opin Immunol. 2015 Apr; 33:126-31. PMID: 25797714; PMCID: PMC4414491.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  40. Tong P, Wesemann DR. Molecular Mechanisms of IgE Class Switch Recombination. Curr Top Microbiol Immunol. 2015; 388:21-37. PMID: 25553793.
    Citations: 17     Fields:    Translation:HumansAnimalsCells
  41. Wesemann DR. Microbes and B cell development. Adv Immunol. 2015; 125:155-78. PMID: 25591467.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  42. Gallagher MP, Shrestha A, Magee JM, Wesemann DR. Detection of true IgE-expressing mouse B lineage cells. J Vis Exp. 2014 Dec 01; (94). PMID: 25490087.
    Citations: 2     Fields:    Translation:AnimalsCells
  43. Wesemann DR, Portuguese AJ, Meyers RM, Gallagher MP, Cluff-Jones K, Magee JM, Panchakshari RA, Rodig SJ, Kepler TB, Alt FW. Microbial colonization influences early B-lineage development in the gut lamina propria. Nature. 2013 Sep 05; 501(7465):112-5. PMID: 23965619.
    Citations: 118     Fields:    Translation:AnimalsCells
  44. Callen E, Di Virgilio M, Kruhlak MJ, Nieto-Soler M, Wong N, Chen HT, Faryabi RB, Polato F, Santos M, Starnes LM, Wesemann DR, Lee JE, Tubbs A, Sleckman BP, Daniel JA, Ge K, Alt FW, Fernandez-Capetillo O, Nussenzweig MC, Nussenzweig A. 53BP1 mediates productive and mutagenic DNA repair through distinct phosphoprotein interactions. Cell. 2013 Jun 06; 153(6):1266-80. PMID: 23727112; PMCID: PMC3713552.
    Citations: 184     Fields:    Translation:AnimalsCells
  45. Wesemann DR, Portuguese AJ, Magee JM, Gallagher MP, Zhou X, Panchakshari RA, Alt FW. Reprogramming IgH isotype-switched B cells to functional-grade induced pluripotent stem cells. Proc Natl Acad Sci U S A. 2012 Aug 21; 109(34):13745-50. PMID: 22869756.
    Citations: 10     Fields:    Translation:AnimalsCells
  46. Oksenych V, Alt FW, Kumar V, Schwer B, Wesemann DR, Hansen E, Patel H, Su A, Guo C. Functional redundancy between repair factor XLF and damage response mediator 53BP1 in V(D)J recombination and DNA repair. Proc Natl Acad Sci U S A. 2012 Feb 14; 109(7):2455-60. PMID: 22308489.
    Citations: 41     Fields:    Translation:AnimalsCells
  47. Wesemann DR, Magee JM, Boboila C, Calado DP, Gallagher MP, Portuguese AJ, Manis JP, Zhou X, Recher M, Rajewsky K, Notarangelo LD, Alt FW. Immature B cells preferentially switch to IgE with increased direct Sµ to Se recombination. J Exp Med. 2011 Dec 19; 208(13):2733-46. PMID: 22143888.
    Citations: 54     Fields:    Translation:AnimalsCells
  48. Basu U, Meng FL, Keim C, Grinstein V, Pefanis E, Eccleston J, Zhang T, Myers D, Wasserman CR, Wesemann DR, Januszyk K, Gregory RI, Deng H, Lima CD, Alt FW. The RNA exosome targets the AID cytidine deaminase to both strands of transcribed duplex DNA substrates. Cell. 2011 Feb 04; 144(3):353-63. PMID: 21255825.
    Citations: 165     Fields:    Translation:HumansAnimalsCells
  49. Zha S, Guo C, Boboila C, Oksenych V, Cheng HL, Zhang Y, Wesemann DR, Yuen G, Patel H, Goff PH, Dubois RL, Alt FW. ATM damage response and XLF repair factor are functionally redundant in joining DNA breaks. Nature. 2011 Jan 13; 469(7329):250-4. PMID: 21160472; PMCID: PMC3058373.
    Citations: 115     Fields:    Translation:AnimalsCells
  50. Boboila C, Yan C, Wesemann DR, Jankovic M, Wang JH, Manis J, Nussenzweig A, Nussenzweig M, Alt FW. Alternative end-joining catalyzes class switch recombination in the absence of both Ku70 and DNA ligase 4. J Exp Med. 2010 Feb 15; 207(2):417-27. PMID: 20142431.
    Citations: 94     Fields:    Translation:AnimalsCells
  51. Boboila C, Jankovic M, Yan CT, Wang JH, Wesemann DR, Zhang T, Fazeli A, Feldman L, Nussenzweig A, Nussenzweig M, Alt FW. Alternative end-joining catalyzes robust IgH locus deletions and translocations in the combined absence of ligase 4 and Ku70. Proc Natl Acad Sci U S A. 2010 Feb 16; 107(7):3034-9. PMID: 20133803.
    Citations: 92     Fields:    Translation:AnimalsCells
  52. Wang JH, Gostissa M, Yan CT, Goff P, Hickernell T, Hansen E, Difilippantonio S, Wesemann DR, Zarrin AA, Rajewsky K, Nussenzweig A, Alt FW. Mechanisms promoting translocations in editing and switching peripheral B cells. Nature. 2009 Jul 09; 460(7252):231-6. PMID: 19587764.
    Citations: 75     Fields:    Translation:AnimalsCells
  53. Wesemann DR, Costenbader KH, Coblyn JS. Co-existing sarcoidosis, systemic lupus erythematosus and the antiphospholipid antibody syndrome: case reports and discussion from the Brigham and Women's Hospital Lupus Center. Lupus. 2009 Mar; 18(3):202-5. PMID: 19213857.
    Citations: 7     Fields:    Translation:Humans
  54. Wesemann DR, Qin H, Kokorina N, Benveniste EN. TRADD interacts with STAT1-alpha and influences interferon-gamma signaling. Nat Immunol. 2004 Feb; 5(2):199-207. PMID: 14730360.
    Citations: 27     Fields:    Translation:AnimalsCells
  55. Benveniste EN, Nguyen VT, Wesemann DR. Molecular regulation of CD40 gene expression in macrophages and microglia. Brain Behav Immun. 2004 Jan; 18(1):7-12. PMID: 14651941.
    Citations: 44     Fields:    Translation:HumansAnimalsCells
  56. Cobbs CS, Whisenhunt TR, Wesemann DR, Harkins LE, Van Meir EG, Samanta M. Inactivation of wild-type p53 protein function by reactive oxygen and nitrogen species in malignant glioma cells. Cancer Res. 2003 Dec 15; 63(24):8670-3. PMID: 14695179.
    Citations: 53     Fields:    Translation:HumansCells
  57. Wesemann DR, Benveniste EN. STAT-1 alpha and IFN-gamma as modulators of TNF-alpha signaling in macrophages: regulation and functional implications of the TNF receptor 1:STAT-1 alpha complex. J Immunol. 2003 Nov 15; 171(10):5313-9. PMID: 14607933.
    Citations: 32     Fields:    Translation:HumansAnimalsCells
  58. Wesemann DR, Dong Y, O'Keefe GM, Nguyen VT, Benveniste EN. Suppressor of cytokine signaling 1 inhibits cytokine induction of CD40 expression in macrophages. J Immunol. 2002 Sep 01; 169(5):2354-60. PMID: 12193701.
    Citations: 20     Fields:    Translation:AnimalsCells
  59. Nashimoto M, Wesemann DR, Geary S, Tamura M, Kaspar RL. Long 5' leaders inhibit removal of a 3' trailer from a precursor tRNA by mammalian tRNA 3' processing endoribonuclease. Nucleic Acids Res. 1999 Jul 01; 27(13):2770-6. PMID: 10373595; PMCID: PMC148487.
    Citations: 17     Fields:    Translation:AnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.