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Duane Wesemann, M.D., Ph.D.

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Biography
2008 - 2008
Outstanding Fellow Award for excellence in teaching
2009 - 2010
AAAAI-GSK Career Development Award
2010 - 2011
AAAAI-Baxter Career Development Award
2011 - 2013
Young Investigator Award in Primary Immune Deficiency
2011 - 2016
Burroughs Wellcome Career Award for Medical Scientists
2013 - 2015
Young Investigator Award in Mucosal Immunity
2015 - 2017
FARE New Investigator Award
2015
Sir William Osler Young Investigator Award

Overview
A diverse repertoire of immunoglobulins (antibodies) is required to build effective immunity against a vast array of infectious threats. However, expanded immunoglobulin diversity raises the risk of generating antibodies directed against self or otherwise innocuous environmental components, which can lead to autoimmune and allergic disorders, respectively. Our lab studies the process of primary immunoglobulin repertoire diversification and how environmental factors, such as commensal microbes and diet, may influence the structure and depth of this diversity. We are particularly interested in how exposures early in life may shape this process. As we work to identify principles regulating the host:environment interactions that modulate the immune system, we seek to deepen our understanding of how this may impact the development of immunity to infection and efficacy of vaccination. In addition, we are undertaking innovative approaches to uncover therapeutic targets for the treatment of allergic disorders such as food allergies and asthma. Please visit the wesemann lab website.

Mentoring
Available: 10/30/18, Expires: 10/30/22

A diverse repertoire of immunoglobulins (antibodies) is required to build effective immunity against a vast array of infectious threats. However, expanded immunoglobulin diversity raises the risk of generating antibodies directed against self or otherwise innocuous environmental components, which can lead to autoimmune and allergic disorders, respectively. Our lab studies the process of primary immunoglobulin repertoire diversification and how environmental factors, such as commensal microbes and diet, may influence the structure and depth of this diversity. We are particularly interested in how exposures early in life may shape this process. As we work to identify principles regulating the host:environment interactions that modulate the immune system, we seek to deepen our understanding of how this may impact the development of immunity to infection and efficacy of vaccination. In addition, we are undertaking innovative approaches to better understand immunologic disorders such as immune deficiency, food allergies and asthma. The summer student project would entail working with more senior lab members in a variety of ongoing projects involving mouse models, biochemistry, or bioinformatic analysis, or computational modeling. The goal for the student would be to contribute enough to a project to warrant credit as an author on a publication.

Available: 10/26/20, Expires: 10/31/25

The Wesemann laboratory, located in the longwood medical area, uses mouse genetics, human studies, cellular biology, single cell transcriptomics, and computation to elucidate the underlying features and elasticity of antibody recognition capacity. We study the dynamic regulation, functional significance, and evolutionary implications/origins of the anticipatory naïve antibody repertoire and its somatically evolving counterpart in germinal centers. Both bench-side as well as computational opportunities are available for students to complete scholarly projects on deciphering features connected to the type and quality of antibody responses.

Current projects include longitudinal analysis of immune responses to SARS-CoV-2 infection as well as responses to COVID-19 vaccines in plasma and cell samples collected by and stored in the Wesemann lab. Bench projects will require some experience with pipetting, ELISAs, cell culture, PCR, and flow cytometry. Computational projects will require some familiarity processing data through tools available at the National Center for Biotechnology Information and the Protein Data Bank with code writing experience in languages such as R. Both in-person and remote projects are available. Both short (4-6 month) and long-term (greater than 6 months) projects are available.


Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01AI139538 (WESEMANN, DUANE R.) Mar 20, 2019 - Feb 28, 2023
    NIH
    Elucidating Germinal Center-Mediated Antibody Evolution
    Role: Principal Investigator
  2. R21AI137940 (WESEMANN, DUANE R.) May 22, 2018 - Apr 30, 2021
    NIH
    Exploring the Role of IgA in Human Immune Homeostasis
    Role: Principal Investigator
  3. R01AI121394 (WESEMANN, DUANE R.) Dec 1, 2015 - Nov 30, 2020
    NIH
    Decrypting IgE B Cell Immunobiology
    Role: Principal Investigator
  4. R01AI113217 (WESEMANN, DUANE R.) Dec 1, 2014 - Nov 30, 2019
    NIH
    Discovering the Role of Commensal Microbes on Primary B Lymphocyte Development
    Role: Principal Investigator
  5. R56AI113217 (WESEMANN, DUANE R.) Aug 1, 2014 - Nov 30, 2014
    NIH
    Discovering the Role of Commensal Microbes on Primary B Lymphocyte Development
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Cai Y, Zhang J, Xiao T, Lavine CL, Rawson S, Peng H, Zhu H, Anand K, Tong P, Gautam A, Lu S, Sterling SM, Walsh RM, Rits-Volloch S, Lu J, Wesemann DR, Yang W, Seaman MS, Chen B. Structural basis for enhanced infectivity and immune evasion of SARS-CoV-2 variants. bioRxiv. 2021 Apr 14. PMID: 33880477.
    Citations:    
  2. Tong P, Gautam A, Windsor I, Travers M, Chen Y, Garcia N, Whiteman NB, McKay LGA, Lelis FJN, Habibi S, Cai Y, Rennick LJ, Duprex WP, McCarthy KR, Lavine CL, Zuo T, Lin J, Zuiani A, Feldman J, MacDonald EA, Hauser BM, Griffths A, Seaman MS, Schmidt AG, Chen B, Neuberg D, Bajic G, Harrison SC, Wesemann DR. Memory B cell repertoire for recognition of evolving SARS-CoV-2 spike. bioRxiv. 2021 Mar 10. PMID: 33758863.
    Citations:    
  3. Atyeo C, Slein MD, Fischinger S, Burke J, Schäfer A, Leist SR, Kuzmina NA, Mire C, Honko A, Johnson R, Storm N, Bernett M, Tong P, Zuo T, Lin J, Zuiani A, Linde C, Suscovich T, Wesemann DR, Griffiths A, Desjarlais JR, Juelg BD, Goudsmit J, Bukreyev A, Baric R, Alter G. Dissecting strategies to tune the therapeutic potential of SARS-CoV-2-specific monoclonal antibody CR3022. JCI Insight. 2021 01 11; 6(1). PMID: 33427208.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  4. Chen Y, Zuiani A, Fischinger S, Mullur J, Atyeo C, Travers M, Lelis FJN, Pullen KM, Martin H, Tong P, Gautam A, Habibi S, Bensko J, Gakpo D, Feldman J, Hauser BM, Caradonna TM, Cai Y, Burke JS, Lin J, Lederer JA, Lam EC, Lavine CL, Seaman MS, Chen B, Schmidt AG, Balazs AB, Lauffenburger DA, Alter G, Wesemann DR. Quick COVID-19 Healers Sustain Anti-SARS-CoV-2 Antibody Production. Cell. 2020 12 10; 183(6):1496-1507.e16. PMID: 33171099.
    Citations: 21     Fields:    Translation:HumansCells
  5. Shrock E, Fujimura E, Kula T, Timms RT, Lee IH, Leng Y, Robinson ML, Sie BM, Li MZ, Chen Y, Logue J, Zuiani A, McCulloch D, Lelis FJN, Henson S, Monaco DR, Travers M, Habibi S, Clarke WA, Caturegli P, Laeyendecker O, Piechocka-Trocha A, Li JZ, Khatri A, Chu HY, Villani AC, Kays K, Goldberg MB, Hacohen N, Filbin MR, Yu XG, Walker BD, Wesemann DR, Larman HB, Lederer JA, Elledge SJ. Viral epitope profiling of COVID-19 patients reveals cross-reactivity and correlates of severity. Science. 2020 11 27; 370(6520). PMID: 32994364.
    Citations: 42     Fields:    Translation:HumansCells
  6. Johnson JA, Pearson JC, Kubiak DW, Dionne B, Little SE, Wesemann DR. Treatment of Chronic Granulomatous Disease-Related Pulmonary Aspergillus Infection in Late Pregnancy. Open Forum Infect Dis. 2020 Oct; 7(10):ofaa447. PMID: 33134418.
    Citations:    
  7. Roy V, Fischinger S, Atyeo C, Slein M, Loos C, Balazs A, Luedemann C, Astudillo MG, Yang D, Wesemann DR, Charles R, Lafrate AJ, Feldman J, Hauser B, Caradonna T, Miller TE, Murali MR, Baden L, Nilles E, Ryan E, Lauffenburger D, Beltran WG, Alter G. SARS-CoV-2-specific ELISA development. J Immunol Methods. 2020 Sep - Oct; 484-485:112832. PMID: 32780998.
    Citations: 11     Fields:    Translation:HumansCellsPHPublic Health
  8. Yu J, Tostanoski LH, Peter L, Mercado NB, McMahan K, Mahrokhian SH, Nkolola JP, Liu J, Li Z, Chandrashekar A, Martinez DR, Loos C, Atyeo C, Fischinger S, Burke JS, Slein MD, Chen Y, Zuiani A, Lelis FJN, Travers M, Habibi S, Pessaint L, Van Ry A, Blade K, Brown R, Cook A, Finneyfrock B, Dodson A, Teow E, Velasco J, Zahn R, Wegmann F, Bondzie EA, Dagotto G, Gebre MS, He X, Jacob-Dolan C, Kirilova M, Kordana N, Lin Z, Maxfield LF, Nampanya F, Nityanandam R, Ventura JD, Wan H, Cai Y, Chen B, Schmidt AG, Wesemann DR, Baric RS, Alter G, Andersen H, Lewis MG, Barouch DH. DNA vaccine protection against SARS-CoV-2 in rhesus macaques. Science. 2020 08 14; 369(6505):806-811. PMID: 32434945.
    Citations: 256     Fields:    Translation:HumansAnimalsCellsPHPublic Health
  9. Wesemann DR, Nagler CR. Origins of peanut allergy-causing antibodies. Science. 2020 03 06; 367(6482):1072-1073. PMID: 32139528.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  10. Wesemann DR. Game of clones: How measles remodels the B cell landscape. Sci Immunol. 2019 11 01; 4(41). PMID: 31672863.
    Citations:    Fields:    Translation:HumansCells
  11. Ng J, Wright K, Alvarez M, Hunninghake GM, Wesemann DR. Rituximab Monotherapy for Common Variable Immune Deficiency-Associated Granulomatous-Lymphocytic Interstitial Lung Disease. Chest. 2019 05; 155(5):e117-e121. PMID: 31060706.
    Citations: 10     Fields:    Translation:HumansCells
  12. Zuo T, Gautam A, Wesemann DR. Affinity war: forging immunoglobulin repertoires. Curr Opin Immunol. 2019 04; 57:32-39. PMID: 30690255.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  13. Gansner JM, Rahmani M, Jonsson AH, Fortin BM, Brimah I, Ellis M, Smeland-Wagman R, Li ZJ, Schenkel JM, Brenner MB, Yefidoff-Freedman R, Sloan SR, Berliner N, Issa NC, Baden LR, Longo DL, Wesemann DR, Neuberg D, Rao DA, Kaufman RM. Plateletpheresis-associated lymphopenia in frequent platelet donors. Blood. 2019 02 07; 133(6):605-614. PMID: 30429159.
    Citations: 2     Fields:    Translation:HumansCells
  14. Chen Y, Chaudhary N, Yang N, Granato A, Turner JA, Howard SL, Devereaux C, Zuo T, Shrestha A, Goel RR, Neuberg D, Wesemann DR. Microbial symbionts regulate the primary Ig repertoire. J Exp Med. 2018 05 07; 215(5):1397-1415. PMID: 29588346.
    Citations: 16     Fields:    Translation:AnimalsCells
  15. Silver JN, Ashbaugh CD, Miles JJ, Wu H, Marecki GT, Hwang JK, Jiao JA, Abrams M, Sullivan EJ, Wesemann DR. Deployment of Transchromosomal Bovine for Personalized Antimicrobial Therapy. Clin Infect Dis. 2018 03 19; 66(7):1116-1119. PMID: 29272362.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  16. Chaudhary N, Wesemann DR. Analyzing Immunoglobulin Repertoires. Front Immunol. 2018; 9:462. PMID: 29593723.
    Citations: 13     Fields:    Translation:HumansAnimals
  17. Silver J, Zuo T, Chaudhary N, Kumari R, Tong P, Giguere S, Granato A, Donthula R, Devereaux C, Wesemann DR. Stochasticity enables BCR-independent germinal center initiation and antibody affinity maturation. J Exp Med. 2018 01 02; 215(1):77-90. PMID: 29247044.
    Citations: 8     Fields:    Translation:AnimalsCells
  18. Renz H, Adkins BD, Bartfeld S, Blumberg RS, Farber DL, Garssen J, Ghazal P, Hackam DJ, Marsland BJ, McCoy KD, Penders J, Prinz I, Verhasselt V, von Mutius E, Weiser JN, Wesemann DR, Hornef MW. The neonatal window of opportunity-early priming for life. J Allergy Clin Immunol. 2018 04; 141(4):1212-1214. PMID: 29247715.
    Citations: 13     Fields:    Translation:HumansPHPublic Health
  19. Tong P, Granato A, Zuo T, Chaudhary N, Zuiani A, Han SS, Donthula R, Shrestha A, Sen D, Magee JM, Gallagher MP, van der Poel CE, Carroll MC, Wesemann DR. IgH isotype-specific B cell receptor expression influences B cell fate. Proc Natl Acad Sci U S A. 2017 10 03; 114(40):E8411-E8420. PMID: 28923960.
    Citations: 6     Fields:    Translation:AnimalsCells
  20. Gosmann C, Anahtar MN, Handley SA, Farcasanu M, Abu-Ali G, Bowman BA, Padavattan N, Desai C, Droit L, Moodley A, Dong M, Chen Y, Ismail N, Ndung'u T, Ghebremichael MS, Wesemann DR, Mitchell C, Dong KL, Huttenhower C, Walker BD, Virgin HW, Kwon DS. Lactobacillus-Deficient Cervicovaginal Bacterial Communities Are Associated with Increased HIV Acquisition in Young South African Women. Immunity. 2017 01 17; 46(1):29-37. PMID: 28087240.
    Citations: 135     Fields:    Translation:HumansAnimalsCells
  21. Wesemann DR, Nagler CR. The Microbiome, Timing, and Barrier Function in the Context of Allergic Disease. Immunity. 2016 Apr 19; 44(4):728-38. PMID: 27096316.
    Citations: 33     Fields:    Translation:HumansCells
  22. Sloane D, Govindarajulu U, Harrow-Mortelliti J, Barry W, Hsu FI, Hong D, Laidlaw T, Palis R, Legere H, Bunyavanich S, Breslow R, Wesemann D, Barrett N, Brennan P, Chong HJ, Liu A, Fernandez J, Fanning L, Kyin T, Cahill K, Bankova L, Lynch A, Berlin S, Campos S, Fuchs C, Mayer R, Matulonis U, Castells M. Safety, Costs, and Efficacy of Rapid Drug Desensitizations to Chemotherapy and Monoclonal Antibodies. J Allergy Clin Immunol Pract. 2016 May-Jun; 4(3):497-504. PMID: 26895621.
    Citations: 18     Fields:    Translation:Humans
  23. Inci F, Filippini C, Baday M, Ozen MO, Calamak S, Durmus NG, Wang S, Hanhauser E, Hobbs KS, Juillard F, Kuang PP, Vetter ML, Carocci M, Yamamoto HS, Takagi Y, Yildiz UH, Akin D, Wesemann DR, Singhal A, Yang PL, Nibert ML, Fichorova RN, Lau DT, Henrich TJ, Kaye KM, Schachter SC, Kuritzkes DR, Steinmetz LM, Gambhir SS, Davis RW, Demirci U. Multitarget, quantitative nanoplasmonic electrical field-enhanced resonating device (NE2RD) for diagnostics. Proc Natl Acad Sci U S A. 2015 Aug 11; 112(32):E4354-63. PMID: 26195743.
    Citations: 17     Fields:    Translation:HumansCells
  24. Granato A, Chen Y, Wesemann DR. Primary immunoglobulin repertoire development: time and space matter. Curr Opin Immunol. 2015 Apr; 33:126-31. PMID: 25797714.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  25. Tong P, Wesemann DR. Molecular Mechanisms of IgE Class Switch Recombination. Curr Top Microbiol Immunol. 2015; 388:21-37. PMID: 25553793.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
  26. Wesemann DR. Microbes and B cell development. Adv Immunol. 2015; 125:155-78. PMID: 25591467.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  27. Gallagher MP, Shrestha A, Magee JM, Wesemann DR. Detection of true IgE-expressing mouse B lineage cells. J Vis Exp. 2014 Dec 01; (94). PMID: 25490087.
    Citations: 1     Fields:    Translation:AnimalsCells
  28. Wesemann DR, Portuguese AJ, Meyers RM, Gallagher MP, Cluff-Jones K, Magee JM, Panchakshari RA, Rodig SJ, Kepler TB, Alt FW. Microbial colonization influences early B-lineage development in the gut lamina propria. Nature. 2013 Sep 05; 501(7465):112-5. PMID: 23965619.
    Citations: 83     Fields:    Translation:AnimalsCells
  29. Callen E, Di Virgilio M, Kruhlak MJ, Nieto-Soler M, Wong N, Chen HT, Faryabi RB, Polato F, Santos M, Starnes LM, Wesemann DR, Lee JE, Tubbs A, Sleckman BP, Daniel JA, Ge K, Alt FW, Fernandez-Capetillo O, Nussenzweig MC, Nussenzweig A. 53BP1 mediates productive and mutagenic DNA repair through distinct phosphoprotein interactions. Cell. 2013 Jun 06; 153(6):1266-80. PMID: 23727112.
    Citations: 150     Fields:    Translation:AnimalsCells
  30. Wesemann DR, Portuguese AJ, Magee JM, Gallagher MP, Zhou X, Panchakshari RA, Alt FW. Reprogramming IgH isotype-switched B cells to functional-grade induced pluripotent stem cells. Proc Natl Acad Sci U S A. 2012 Aug 21; 109(34):13745-50. PMID: 22869756.
    Citations: 7     Fields:    Translation:AnimalsCells
  31. Oksenych V, Alt FW, Kumar V, Schwer B, Wesemann DR, Hansen E, Patel H, Su A, Guo C. Functional redundancy between repair factor XLF and damage response mediator 53BP1 in V(D)J recombination and DNA repair. Proc Natl Acad Sci U S A. 2012 Feb 14; 109(7):2455-60. PMID: 22308489.
    Citations: 30     Fields:    Translation:AnimalsCells
  32. Wesemann DR, Magee JM, Boboila C, Calado DP, Gallagher MP, Portuguese AJ, Manis JP, Zhou X, Recher M, Rajewsky K, Notarangelo LD, Alt FW. Immature B cells preferentially switch to IgE with increased direct Sµ to Se recombination. J Exp Med. 2011 Dec 19; 208(13):2733-46. PMID: 22143888.
    Citations: 46     Fields:    Translation:AnimalsCells
  33. Basu U, Meng FL, Keim C, Grinstein V, Pefanis E, Eccleston J, Zhang T, Myers D, Wasserman CR, Wesemann DR, Januszyk K, Gregory RI, Deng H, Lima CD, Alt FW. The RNA exosome targets the AID cytidine deaminase to both strands of transcribed duplex DNA substrates. Cell. 2011 Feb 04; 144(3):353-63. PMID: 21255825.
    Citations: 147     Fields:    Translation:HumansAnimalsCells
  34. Zha S, Guo C, Boboila C, Oksenych V, Cheng HL, Zhang Y, Wesemann DR, Yuen G, Patel H, Goff PH, Dubois RL, Alt FW. ATM damage response and XLF repair factor are functionally redundant in joining DNA breaks. Nature. 2011 Jan 13; 469(7329):250-4. PMID: 21160472.
    Citations: 92     Fields:    Translation:AnimalsCells
  35. Boboila C, Yan C, Wesemann DR, Jankovic M, Wang JH, Manis J, Nussenzweig A, Nussenzweig M, Alt FW. Alternative end-joining catalyzes class switch recombination in the absence of both Ku70 and DNA ligase 4. J Exp Med. 2010 Feb 15; 207(2):417-27. PMID: 20142431.
    Citations: 79     Fields:    Translation:AnimalsCells
  36. Boboila C, Jankovic M, Yan CT, Wang JH, Wesemann DR, Zhang T, Fazeli A, Feldman L, Nussenzweig A, Nussenzweig M, Alt FW. Alternative end-joining catalyzes robust IgH locus deletions and translocations in the combined absence of ligase 4 and Ku70. Proc Natl Acad Sci U S A. 2010 Feb 16; 107(7):3034-9. PMID: 20133803.
    Citations: 80     Fields:    Translation:AnimalsCells
  37. Wang JH, Gostissa M, Yan CT, Goff P, Hickernell T, Hansen E, Difilippantonio S, Wesemann DR, Zarrin AA, Rajewsky K, Nussenzweig A, Alt FW. Mechanisms promoting translocations in editing and switching peripheral B cells. Nature. 2009 Jul 09; 460(7252):231-6. PMID: 19587764.
    Citations: 75     Fields:    Translation:AnimalsCells
  38. Wesemann DR, Costenbader KH, Coblyn JS. Co-existing sarcoidosis, systemic lupus erythematosus and the antiphospholipid antibody syndrome: case reports and discussion from the Brigham and Women's Hospital Lupus Center. Lupus. 2009 Mar; 18(3):202-5. PMID: 19213857.
    Citations: 7     Fields:    Translation:Humans
  39. Wesemann DR, Qin H, Kokorina N, Benveniste EN. TRADD interacts with STAT1-alpha and influences interferon-gamma signaling. Nat Immunol. 2004 Feb; 5(2):199-207. PMID: 14730360.
    Citations: 25     Fields:    Translation:AnimalsCells
  40. Benveniste EN, Nguyen VT, Wesemann DR. Molecular regulation of CD40 gene expression in macrophages and microglia. Brain Behav Immun. 2004 Jan; 18(1):7-12. PMID: 14651941.
    Citations: 43     Fields:    Translation:HumansAnimalsCells
  41. Cobbs CS, Whisenhunt TR, Wesemann DR, Harkins LE, Van Meir EG, Samanta M. Inactivation of wild-type p53 protein function by reactive oxygen and nitrogen species in malignant glioma cells. Cancer Res. 2003 Dec 15; 63(24):8670-3. PMID: 14695179.
    Citations: 42     Fields:    Translation:HumansCells
  42. Wesemann DR, Benveniste EN. STAT-1 alpha and IFN-gamma as modulators of TNF-alpha signaling in macrophages: regulation and functional implications of the TNF receptor 1:STAT-1 alpha complex. J Immunol. 2003 Nov 15; 171(10):5313-9. PMID: 14607933.
    Citations: 24     Fields:    Translation:HumansAnimalsCells
  43. Wesemann DR, Dong Y, O'Keefe GM, Nguyen VT, Benveniste EN. Suppressor of cytokine signaling 1 inhibits cytokine induction of CD40 expression in macrophages. J Immunol. 2002 Sep 01; 169(5):2354-60. PMID: 12193701.
    Citations: 19     Fields:    Translation:AnimalsCells
  44. Nashimoto M, Wesemann DR, Geary S, Tamura M, Kaspar RL. Long 5' leaders inhibit removal of a 3' trailer from a precursor tRNA by mammalian tRNA 3' processing endoribonuclease. Nucleic Acids Res. 1999 Jul 01; 27(13):2770-6. PMID: 10373595.
    Citations: 15     Fields:    Translation:AnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.