Harvard Catalyst Profiles

Contact, publication, and social network information about Harvard faculty and fellows.

Andrew Mark Strassman, Ph.D.

Title
Institution
Department
Address
Phone
Fax

Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R21NS106345 (STRASSMAN, ANDREW MARK) Apr 1, 2018 - Mar 31, 2020
    NIH/NINDS
    Characterization of sleep behavior in a rodent model of headache
    Role: Principal Investigator
  2. R21NS085510 (STRASSMAN, ANDREW MARK) Sep 15, 2013 - Aug 31, 2015
    NIH/NINDS
    Rodent Behavioral Model of Ongoing Headache Pain
    Role: Principal Investigator
  3. R21NS064381 (STRASSMAN, ANDREW MARK) Jan 1, 2009 - Dec 31, 2011
    NIH/NINDS
    In Vivo Patch Clamp Studies of Dorsal Horn Neurons in Relation to Headache
    Role: Principal Investigator
  4. R01NS057454 (STRASSMAN, ANDREW MARK) Jul 1, 2007 - Jun 30, 2013
    NIH/NINDS
    High Resolution of Mapping of Pain Ciruity in the Dorsal Horn
    Role: Principal Investigator
  5. R21NS047371 (STRASSMAN, ANDREW MARK) Jan 15, 2005 - Aug 31, 2007
    NIH/NINDS
    High Resolution Mapping of Pain in the Dorsal Horn
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Schain AJ, Melo A, Stratton J, Strassman AM, Burstein R. CSD-induced arterial dilatation and plasma protein extravasation are unaffected by fremanezumab: implications for CGRP's role in migraine with aura. J Neurosci. 2019 May 24. PMID: 31127003.
    Citations:    
  2. Noseda R, Melo-Carrillo A, Nir RR, Strassman AM, Burstein R. Non-Trigeminal Nociceptive Innervation of the Posterior Dura: Implications to Occipital Headache. J Neurosci. 2019 Mar 06; 39(10):1867-1880. PMID: 30622169.
    Citations:    Fields:    
  3. Schain AJ, Melo-Carrillo A, Borsook D, Grutzendler J, Strassman AM, Burstein R. Activation of pial and dural macrophages and dendritic cells by cortical spreading depression. Ann Neurol. 2018 Mar; 83(3):508-521. PMID: 29394508.
    Citations: 1     Fields:    
  4. Melo-Carrillo A, Strassman AM, Nir RR, Schain AJ, Noseda R, Stratton J, Burstein R. Fremanezumab-A Humanized Monoclonal Anti-CGRP Antibody-Inhibits Thinly Myelinated (Ad) But Not Unmyelinated (C) Meningeal Nociceptors. J Neurosci. 2017 11 01; 37(44):10587-10596. PMID: 28972120.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  5. Melo-Carrillo A, Noseda R, Nir RR, Schain AJ, Stratton J, Strassman AM, Burstein R. Selective Inhibition of Trigeminovascular Neurons by Fremanezumab: A Humanized Monoclonal Anti-CGRP Antibody. J Neurosci. 2017 07 26; 37(30):7149-7163. PMID: 28642283.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  6. Strassman A, Schnütgen F, Dai Q, Jones JC, Gomez AC, Pitstick L, Holton NE, Moskal R, Leslie ER, von Melchner H, Beier DR, Bjork BC. Generation of a multipurpose Prdm16 mouse allele by targeted gene trapping. Dis Model Mech. 2017 07 01; 10(7):909-922. PMID: 28424158.
    Citations:    Fields:    Translation:AnimalsCells
  7. Schain AJ, Melo-Carrillo A, Strassman AM, Burstein R. Cortical Spreading Depression Closes Paravascular Space and Impairs Glymphatic Flow: Implications for Migraine Headache. J Neurosci. 2017 03 15; 37(11):2904-2915. PMID: 28193695.
    Citations: 10     Fields:    Translation:AnimalsCells
  8. Zhao J, Bree D, Harrington MG, Strassman AM, Levy D. Cranial dural permeability of inflammatory nociceptive mediators: Potential implications for animal models of migraine. Cephalalgia. 2017 Oct; 37(11):1017-1025. PMID: 27493234.
    Citations: 1     Fields:    Translation:AnimalsCells
  9. Kato G, Inada H, Wake H, Akiyoshi R, Miyamoto A, Eto K, Ishikawa T, Moorhouse AJ, Strassman AM, Nabekura J. Microglial Contact Prevents Excess Depolarization and Rescues Neurons from Excitotoxicity. eNeuro. 2016 May-Jun; 3(3). PMID: 27390772.
    Citations: 7     Fields:    Translation:AnimalsCells
  10. Borsook D, Linnman C, Faria V, Strassman AM, Becerra L, Elman I. Reward deficiency and anti-reward in pain chronification. Neurosci Biobehav Rev. 2016 Sep; 68:282-297. PMID: 27246519.
    Citations: 14     Fields:    
  11. Zhang X, Strassman AM, Novack V, Brin MF, Burstein R. Extracranial injections of botulinum neurotoxin type A inhibit intracranial meningeal nociceptors' responses to stimulation of TRPV1 and TRPA1 channels: Are we getting closer to solving this puzzle? Cephalalgia. 2016 Aug; 36(9):875-86. PMID: 26984967.
    Citations: 5     Fields:    Translation:AnimalsCells
  12. Kato G, Kosugi M, Mizuno M, Strassman AM. Three-dimensional organization of local excitatory and inhibitory inputs to neurons in laminae III-IV of the spinal dorsal horn. J Physiol. 2013 Nov 15; 591(22):5645-60. PMID: 23981716.
    Citations:    Fields:    Translation:AnimalsCells
  13. Zhang X, Kainz V, Zhao J, Strassman AM, Levy D. Vascular extracellular signal-regulated kinase mediates migraine-related sensitization of meningeal nociceptors. Ann Neurol. 2013 Jun; 73(6):741-50. PMID: 23447360.
    Citations: 13     Fields:    Translation:AnimalsCells
  14. Strassman AM, Burstein R. A new animal model of headache: Ongoing pain vs stimulus-evoked hypersensitivity. Cephalalgia. 2013 Oct; 33(13):1073-4. PMID: 23766356.
    Citations: 2     Fields:    Translation:Animals
  15. Kosugi M, Kato G, Lukashov S, Pendse G, Puskar Z, Kozsurek M, Strassman AM. Subpopulation-specific patterns of intrinsic connectivity in mouse superficial dorsal horn as revealed by laser scanning photostimulation. J Physiol. 2013 Apr 01; 591(7):1935-49. PMID: 23297304.
    Citations: 6     Fields:    Translation:AnimalsCells
  16. Burstein R, Strassman A, Moskowitz M. Can cortical spreading depression activate central trigeminovascular neurons without peripheral input? Pitfalls of a new concept. Cephalalgia. 2012 Apr; 32(6):509-11. PMID: 22345633.
    Citations: 5     Fields:    Translation:AnimalsCells
  17. Kato G, Kosugi M, Mizuno M, Strassman AM. Separate inhibitory and excitatory components underlying receptive field organization in superficial medullary dorsal horn neurons. J Neurosci. 2011 Nov 23; 31(47):17300-5. PMID: 22114296.
    Citations: 6     Fields:    Translation:AnimalsCells
  18. Levy D, Kainz V, Burstein R, Strassman AM. Mast cell degranulation distinctly activates trigemino-cervical and lumbosacral pain pathways and elicits widespread tactile pain hypersensitivity. Brain Behav Immun. 2012 Feb; 26(2):311-7. PMID: 22019552.
    Citations: 30     Fields:    Translation:AnimalsCells
  19. Levy D, Strassman AM, Burstein R. A critical view on the role of migraine triggers in the genesis of migraine pain. Headache. 2009 Jun; 49(6):953-7. PMID: 19545256.
    Citations: 21     Fields:    Translation:HumansCells
  20. Kato G, Kawasaki Y, Koga K, Uta D, Kosugi M, Yasaka T, Yoshimura M, Ji RR, Strassman AM. Organization of intralaminar and translaminar neuronal connectivity in the superficial spinal dorsal horn. J Neurosci. 2009 Apr 22; 29(16):5088-99. PMID: 19386904.
    Citations: 24     Fields:    Translation:AnimalsCells
  21. Zhang XC, Kainz V, Jakubowski M, Burstein R, Strassman A, Levy D. Localization of COX-1 and COX-2 in the intracranial dura mater of the rat. Neurosci Lett. 2009 Mar 06; 452(1):33-6. PMID: 19444941.
    Citations: 8     Fields:    Translation:AnimalsCells
  22. Zhang XC, Strassman AM, Burstein R, Levy D. Sensitization and activation of intracranial meningeal nociceptors by mast cell mediators. J Pharmacol Exp Ther. 2007 Aug; 322(2):806-12. PMID: 17483291.
    Citations: 41     Fields:    Translation:AnimalsCells
  23. Levy D, Burstein R, Kainz V, Jakubowski M, Strassman AM. Mast cell degranulation activates a pain pathway underlying migraine headache. Pain. 2007 Jul; 130(1-2):166-76. PMID: 17459586.
    Citations: 85     Fields:    Translation:AnimalsCells
  24. Moulton EA, Pendse G, Morris S, Strassman A, Aiello-Lammens M, Becerra L, Borsook D. Capsaicin-induced thermal hyperalgesia and sensitization in the human trigeminal nociceptive pathway: an fMRI study. Neuroimage. 2007 May 01; 35(4):1586-600. PMID: 17407825.
    Citations: 19     Fields:    Translation:HumansCells
  25. Kato G, Kawasaki Y, Ji RR, Strassman AM. Differential wiring of local excitatory and inhibitory synaptic inputs to islet cells in rat spinal lamina II demonstrated by laser scanning photostimulation. J Physiol. 2007 May 01; 580(Pt.3):815-33. PMID: 17289782.
    Citations: 10     Fields:    Translation:AnimalsCells
  26. Levy D, Burstein R, Strassman AM. Mast cell involvement in the pathophysiology of migraine headache: A hypothesis. Headache. 2006 Jun; 46 Suppl 1:S13-8. PMID: 16927959.
    Citations: 17     Fields:    Translation:HumansCells
  27. Strassman AM, Levy D. Response properties of dural nociceptors in relation to headache. J Neurophysiol. 2006 Mar; 95(3):1298-306. PMID: 16492942.
    Citations: 42     Fields:    Translation:HumansAnimalsCells
  28. Levy D, Burstein R, Strassman AM. Calcitonin gene-related peptide does not excite or sensitize meningeal nociceptors: implications for the pathophysiology of migraine. Ann Neurol. 2005 Nov; 58(5):698-705. PMID: 16240341.
    Citations: 57     Fields:    Translation:AnimalsCells
  29. Strassman AM, Levy D. The anti-migraine agent sumatriptan induces a calcium-dependent discharge in meningeal sensory neurons. Neuroreport. 2004 Jun 28; 15(9):1409-12. PMID: 15194863.
    Citations: 4     Fields:    Translation:AnimalsCells
  30. Strassman AM, Weissner W, Williams M, Ali S, Levy D. Axon diameters and intradural trajectories of the dural innervation in the rat. J Comp Neurol. 2004 May 31; 473(3):364-76. PMID: 15116396.
    Citations: 20     Fields:    Translation:AnimalsCells
  31. Levy D, Strassman AM. Modulation of dural nociceptor mechanosensitivity by the nitric oxide-cyclic GMP signaling cascade. J Neurophysiol. 2004 Aug; 92(2):766-72. PMID: 15056690.
    Citations: 12     Fields:    Translation:AnimalsCells
  32. Levy D, Strassman AM. Mechanical response properties of A and C primary afferent neurons innervating the rat intracranial dura. J Neurophysiol. 2002 Dec; 88(6):3021-31. PMID: 12466427.
    Citations: 32     Fields:    Translation:AnimalsCells
  33. DaSilva AF, Becerra L, Makris N, Strassman AM, Gonzalez RG, Geatrakis N, Borsook D. Somatotopic activation in the human trigeminal pain pathway. J Neurosci. 2002 Sep 15; 22(18):8183-92. PMID: 12223572.
    Citations: 47     Fields:    Translation:HumansCellsCTClinical Trials
  34. Levy D, Strassman AM. Distinct sensitizing effects of the cAMP-PKA second messenger cascade on rat dural mechanonociceptors. J Physiol. 2002 Jan 15; 538(Pt 2):483-93. PMID: 11790814.
    Citations: 23     Fields:    Translation:AnimalsCells
  35. Strassman AM, Raymond SA. Electrophysiological evidence for tetrodotoxin-resistant sodium channels in slowly conducting dural sensory fibers. J Neurophysiol. 1999 Feb; 81(2):413-24. PMID: 10036248.
    Citations: 20     Fields:    Translation:AnimalsCells
  36. Burstein R, Yamamura H, Malick A, Strassman AM. Chemical stimulation of the intracranial dura induces enhanced responses to facial stimulation in brain stem trigeminal neurons. J Neurophysiol. 1998 Feb; 79(2):964-82. PMID: 9463456.
    Citations: 131     Fields:    Translation:AnimalsCells
  37. Strassman AM, Raymond SA. On the origin of headaches. Endeavour. 1997; 21(3):97-100. PMID: 9363689.
    Citations: 4     Fields:    Translation:HumansCells
  38. Strassman AM, Raymond SA, Burstein R. Sensitization of meningeal sensory neurons and the origin of headaches. Nature. 1996 Dec 12; 384(6609):560-4. PMID: 8955268.
    Citations: 140     Fields:    Translation:AnimalsCells
  39. Burstein R, Falkowsky O, Borsook D, Strassman A. Distinct lateral and medial projections of the spinohypothalamic tract of the rat. J Comp Neurol. 1996 Sep 30; 373(4):549-74. PMID: 8889944.
    Citations: 3     Fields:    Translation:AnimalsCells
  40. Eisenberg E, Vos BP, Strassman AM. The peripheral antinociceptive effect of morphine in a rat model of facial pain. Neuroscience. 1996 May; 72(2):519-25. PMID: 8737420.
    Citations: 9     Fields:    Translation:AnimalsCells
  41. Vos BP, Strassman AM. Fos expression in the medullary dorsal horn of the rat after chronic constriction injury to the infraorbital nerve. J Comp Neurol. 1995 Jul 03; 357(3):362-75. PMID: 7673473.
    Citations: 3     Fields:    Translation:Animals
  42. Eisenberg E, LaCross S, Strassman AM. The clinically tested N-methyl-D-aspartate receptor antagonist memantine blocks and reverses thermal hyperalgesia in a rat model of painful mononeuropathy. Neurosci Lett. 1995 Feb 24; 187(1):17-20. PMID: 7617292.
    Citations: 6     Fields:    Translation:Animals
  43. Mineta Y, Eisenberg E, Strassman AM. Distribution of Fos-like immunoreactivity in the caudal medullary reticular formation following noxious facial stimulation in the rat. Exp Brain Res. 1995; 107(1):34-8. PMID: 8751060.
    Citations: 2     Fields:    Translation:AnimalsCells
  44. Strassman AM, Potrebic S, Maciewicz RJ. Anatomical properties of brainstem trigeminal neurons that respond to electrical stimulation of dural blood vessels. J Comp Neurol. 1994 Aug 15; 346(3):349-65. PMID: 7995855.
    Citations: 5     Fields:    Translation:AnimalsCells
  45. Strassman AM, Mineta Y, Vos BP. Distribution of fos-like immunoreactivity in the medullary and upper cervical dorsal horn produced by stimulation of dural blood vessels in the rat. J Neurosci. 1994 Jun; 14(6):3725-35. PMID: 8207485.
    Citations: 29     Fields:    Translation:Animals
  46. Vos BP, Strassman AM, Maciewicz RJ. Behavioral evidence of trigeminal neuropathic pain following chronic constriction injury to the rat's infraorbital nerve. J Neurosci. 1994 May; 14(5 Pt 1):2708-23. PMID: 8182437.
    Citations: 92     Fields:    Translation:Animals
  47. Eisenberg E, LaCross S, Strassman AM. The effects of the clinically tested NMDA receptor antagonist memantine on carrageenan-induced thermal hyperalgesia in rats. Eur J Pharmacol. 1994 Apr 01; 255(1-3):123-9. PMID: 8026538.
    Citations: 8     Fields:    Translation:Animals
  48. Borsook D, Falkowski O, Burstein R, Strassman A, Konradi C, Dauber A, Comb M, Hyman SE. Stress-induced regulation of a human proenkephalin-beta-galactosidase fusion gene in the hypothalamus of transgenic mice. Mol Endocrinol. 1994 Jan; 8(1):116-25. PMID: 8152426.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  49. Strassman AM, Vos BP, Mineta Y, Naderi S, Borsook D, Burstein R. Fos-like immunoreactivity in the superficial medullary dorsal horn induced by noxious and innocuous thermal stimulation of facial skin in the rat. J Neurophysiol. 1993 Nov; 70(5):1811-21. PMID: 8294956.
    Citations: 13     Fields:    Translation:AnimalsCells
  50. Eisenberg E, Vos BP, Strassman AM. The NMDA antagonist Memantine blocks pain behavior in a rat model of formalin-induced facial pain. Pain. 1993 Sep; 54(3):301-7. PMID: 8233544.
    Citations: 8     Fields:    Translation:Animals
  51. Strassman AM, Vos BP. Somatotopic and laminar organization of fos-like immunoreactivity in the medullary and upper cervical dorsal horn induced by noxious facial stimulation in the rat. J Comp Neurol. 1993 May 22; 331(4):495-516. PMID: 8509507.
    Citations: 45     Fields:    Translation:AnimalsCells
  52. Potrebic S, Strassman A, Hartwieg EA, Maciewicz R. Ultrastructure of intracellularly labeled trigeminal vascular convergence neurons. Brain Res. 1990 Jan 22; 507(2):317-20. PMID: 2337772.
    Citations:    Fields:    Translation:Animals
  53. Maciewicz R, Mason P, Strassman A, Potrebic S. Organization of trigeminal nociceptive pathways. Semin Neurol. 1988 Dec; 8(4):255-64. PMID: 2854905.
    Citations:    Fields:    Translation:HumansAnimalsCells
  54. Mason P, Strassman A, Maciewicz R. Serotonin immunocytochemistry of physiologically characterized raphe magnus neurons. Exp Brain Res. 1988; 73(1):1-7. PMID: 3208850.
    Citations: 3     Fields:    Translation:Animals
  55. Chung RY, Mason P, Strassman A, Maciewicz R. Edinger-Westphal nucleus: cells that project to spinal cord contain corticotropin-releasing factor. Neurosci Lett. 1987 Dec 16; 83(1-2):13-9. PMID: 2831475.
    Citations: 2     Fields:    Translation:AnimalsCells
  56. McCrea RA, Strassman A, May E, Highstein SM. Anatomical and physiological characteristics of vestibular neurons mediating the horizontal vestibulo-ocular reflex of the squirrel monkey. J Comp Neurol. 1987 Oct 22; 264(4):547-70. PMID: 2824574.
    Citations: 34     Fields:    Translation:AnimalsCells
  57. McCrea RA, Strassman A, Highstein SM. Anatomical and physiological characteristics of vestibular neurons mediating the vertical vestibulo-ocular reflexes of the squirrel monkey. J Comp Neurol. 1987 Oct 22; 264(4):571-94. PMID: 2824575.
    Citations: 23     Fields:    Translation:AnimalsCells
  58. Strassman A, Mason P, Eckenstein F, Baughman RW, Maciewicz R. Choline acetyltransferase immunocytochemistry of Edinger-Westphal and ciliary ganglion afferent neurons in the cat. Brain Res. 1987 Oct 13; 423(1-2):293-304. PMID: 2445447.
    Citations: 5     Fields:    Translation:AnimalsCells
  59. Chung RY, Mason P, Strassman A, Maciewicz R. Suppression of the jaw-opening reflex by periaqueductal gray stimulation is decreased by paramedian brainstem lesions. Brain Res. 1987 Feb 10; 403(1):172-6. PMID: 3548886.
    Citations:    Fields:    Translation:Animals
  60. Strassman A, Evinger C, McCrea RA, Baker RG, Highstein SM. Anatomy and physiology of intracellularly labelled omnipause neurons in the cat and squirrel monkey. Exp Brain Res. 1987; 67(2):436-40. PMID: 3622701.
    Citations: 17     Fields:    Translation:Animals
  61. Strassman A, Mason P, Moskowitz M, Maciewicz R. Response of brainstem trigeminal neurons to electrical stimulation of the dura. Brain Res. 1986 Aug 06; 379(2):242-50. PMID: 3742223.
    Citations: 24     Fields:    Translation:AnimalsCells
  62. Mason P, Strassman A, Maciewicz R. Intracellular responses of raphe magnus neurons during the jaw-opening reflex evoked by tooth pulp stimulation. Brain Res. 1986 Aug 06; 379(2):232-41. PMID: 3742222.
    Citations: 3     Fields:    Translation:AnimalsCells
  63. Strassman A, Highstein SM, McCrea RA. Anatomy and physiology of saccadic burst neurons in the alert squirrel monkey. I. Excitatory burst neurons. J Comp Neurol. 1986 Jul 15; 249(3):337-57. PMID: 3734160.
    Citations: 45     Fields:    Translation:Animals
  64. Strassman A, Highstein SM, McCrea RA. Anatomy and physiology of saccadic burst neurons in the alert squirrel monkey. II. Inhibitory burst neurons. J Comp Neurol. 1986 Jul 15; 249(3):358-80. PMID: 3734161.
    Citations: 36     Fields:    Translation:Animals
  65. McCrea RA, Strassman A, Highstein SM. Morphology and physiology of abducens motoneurons and internuclear neurons intracellularly injected with horseradish peroxidase in alert squirrel monkeys. J Comp Neurol. 1986 Jan 15; 243(3):291-308. PMID: 3512626.
    Citations: 8     Fields:    Translation:AnimalsCells
  66. Mason P, Strassman A, Maciewicz R. Is the jaw-opening reflex a valid model of pain? Brain Res. 1985 Oct; 357(2):137-46. PMID: 3931861.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  67. Mason P, Strassman A, Maciewicz R. Pontomedullary raphe neurons: monosynaptic excitation from midbrain sites that suppress the jaw opening reflex. Brain Res. 1985 Mar 11; 329(1-2):384-9. PMID: 3978461.
    Citations: 3     Fields:    Translation:Animals
  68. Reisine H, Strassman A, Highstein SM. Eye position and head velocity signals are conveyed to medial rectus motoneurons in the alert cat by the ascending tract of Deiters'. Brain Res. 1981 Apr 27; 211(1):153-7. PMID: 7225829.
    Citations: 6     Fields:    Translation:AnimalsCells
Local representatives can answer questions about the Profiles website or help with editing a profile or issues with profile data. For assistance with this profile: HMS/HSDM faculty should contact feedbackcatalyst.harvard.edu. For faculty or fellow appointment updates and changes, please ask your appointing department to contact HMS. For fellow personal and demographic information, contact HMS Human Resources at human_resourceshms.harvard.edu. For faculty personal and demographic information, contact HMS Office for Faculty Affairs at facappthms.harvard.edu.
Strassman's Networks
Click the
Explore
buttons for more information and interactive visualizations!
Concepts (298)
Explore
_
Co-Authors (11)
Explore
_
Similar People (60)
Explore
_
Same Department 
Explore
_
Physical Neighbors
_
Funded by the NIH/NCATS Clinical and Translational Science Award (CTSA) program, grant number UL1TR001102, and through institutional support from Harvard University, Harvard Medical School, Harvard T.H. Chan School of Public Health, Beth Israel Deaconess Medical Center, Boston Children's Hospital, Brigham and Women's Hospital, Massachusetts General Hospital and the Dana Farber Cancer Institute.