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profileYves Boucher, PH.D.

TitleAssociate Professor of Radiation Oncology
InstitutionMassachusetts General Hospital
DepartmentRadiation Oncology
AddressMassachusetts General Hospital
Radiation Oncology, Cox 7
55 Fruit St
Boston MA 02114
Phone617/726-8143
Fax617/726-1962
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Collapse Research 
Collapse research activities and funding
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
R21CA173518     (BOUCHER, YVES)Jul 3, 2013 - Jun 30, 2015
NIH/NCI
Breakdown of Desmoplasia in Pancreatic Cancer to Enhance Drug Effectiveness
Role: Principal Investigator

R01CA098706     (BOUCHER, YVES)Dec 1, 2002 - Apr 30, 2014
NIH/NCI
Transport of Large Molecules and Viral Vectors in Tumors: Effects of Cytotoxic an
Role: Principal Investigator

P01CA080124     (JAIN, RAKESH K.)Aug 11, 2000 - Apr 30, 2017
NIH/NCI
Integrative Pathophysiology of Solid Tumors
Role: Co-Principal Investigator

Collapse Bibliographic 
Collapse selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Lecor PA, Touré B, Boucher Y. Trigemino-gustatory interactions: a randomized controlled clinical trial assessing the effects of selective anesthesia of dental afferents on taste thresholds. Clin Oral Investig. 2017 Aug 31. PMID: 28861746.
    View in: PubMed
  2. Dieb W, Boucher Y. Burning Mouth Syndome and Vitamin B6. Pain Med. 2017 Aug 01; 18(8):1593-1594. PMID: 28371806.
    View in: PubMed
  3. Liu H, Naxerova K, Pinter M, Incio J, Lee H, Shigeta K, Ho WW, Crain JA, Jacobson A, Michelakos T, Dias-Santos D, Zanconato A, Hong TS, Clark JW, Murphy JE, Ryan DP, Deshpande V, Lillemoe KD, Fernandez-Del Castillo C, Downes M, Evans RM, Michaelson J, Ferrone CR, Boucher Y, Jain RK. Use of Angiotensin System Inhibitors Is Associated with Immune Activation and Longer Survival in Nonmetastatic Pancreatic Ductal Adenocarcinoma. Clin Cancer Res. 2017 Jun 09. PMID: 28600474.
    View in: PubMed
  4. Dieb W, Moreau N, Chemla I, Descroix V, Boucher Y. Neuropathic pain in the orofacial region: The role of pain history. A retrospective study. J Stomatol Oral Maxillofac Surg. 2017 Jun; 118(3):147-150. PMID: 28365394.
    View in: PubMed
  5. Braud A, Descroix V, Ungeheuer MN, Rougeot C, Boucher Y. Taste function assessed by electrogustometry in burning mouth syndrome: a case-control study. Oral Dis. 2017 Apr; 23(3):395-402. PMID: 28029722.
    View in: PubMed
  6. Moreau N, Dieb W, Descroix V, Svensson P, Ernberg M, Boucher Y. Topical Review: Potential Use of Botulinum Toxin in the Management of Painful Posttraumatic Trigeminal Neuropathy. J Oral Facial Pain Headache. 2017 Winter; 31(1):7-18. PMID: 28118416.
    View in: PubMed
  7. Moreau N, Mauborgne A, Couraud PO, Romero IA, Weksler BB, Villanueva L, Pohl M, Boucher Y. [EXPRESS] Could an endoneurial endothelial crosstalk between Wnt/ß-catenin and Sonic Hedgehog pathways underlie the early disruption of the infra-orbital blood-nerve barrier following chronic constriction injury? Mol Pain. 2017 Jan-Dec; 13:1744806917727625. PMID: 28814148.
    View in: PubMed
  8. Martin JD, Fukumura D, Duda DG, Boucher Y, Jain RK. Reengineering the Tumor Microenvironment to Alleviate Hypoxia and Overcome Cancer Heterogeneity. Cold Spring Harb Perspect Med. 2016 Dec 01; 6(12). PMID: 27663981.
    View in: PubMed
  9. Martin JD, Fukumura D, Duda DG, Boucher Y, Jain RK. Corrigendum: Reengineering the Tumor Microenvironment to Alleviate Hypoxia and Overcome Cancer Heterogeneity. Cold Spring Harb Perspect Med. 2016 Dec 01; 6(12). PMID: 27908927.
    View in: PubMed
  10. Moreau N, Dieb W, Mauborgne A, Bourgoin S, Villanueva L, Pohl M, Boucher Y. Hedgehog Pathway-Mediated Vascular Alterations Following Trigeminal Nerve Injury. J Dent Res. 2017 Apr; 96(4):450-457. PMID: 27856965.
    View in: PubMed
  11. Boucher Y, Braud A, Dufour E, Agbo-Godeau S, Baaroun V, Descroix V, Guinnepain MT, Ungeheuer MN, Ottone C, Rougeot C. Opiorphin levels in fluids of burning mouth syndrome patients: a case-control study. Clin Oral Investig. 2016 Nov 10. PMID: 27834029.
    View in: PubMed
  12. Rahbari NN, Kedrin D, Incio J, Liu H, Ho WW, Nia HT, Edrich CM, Jung K, Daubriac J, Chen I, Heishi T, Martin JD, Huang Y, Maimon N, Reissfelder C, Weitz J, Boucher Y, Clark JW, Grodzinsky AJ, Duda DG, Jain RK, Fukumura D. Anti-VEGF therapy induces ECM remodeling and mechanical barriers to therapy in colorectal cancer liver metastases. Sci Transl Med. 2016 Oct 12; 8(360):360ra135. PMID: 27733559.
    View in: PubMed
  13. Kumar V, Boucher Y, Liu H, Ferreira D, Hooker J, Catana C, Hoover AJ, Ritter T, Jain RK, Guimaraes AR. Noninvasive Assessment of Losartan-Induced Increase in Functional Microvasculature and Drug Delivery in Pancreatic Ductal Adenocarcinoma. Transl Oncol. 2016 Oct; 9(5):431-437. PMID: 27751347.
    View in: PubMed
  14. Incio J, Liu H, Suboj P, Chin SM, Chen IX, Pinter M, Ng MR, Nia HT, Grahovac J, Kao S, Babykutty S, Huang Y, Jung K, Rahbari NN, Han X, Chauhan VP, Martin JD, Kahn J, Huang P, Desphande V, Michaelson J, Michelakos TP, Ferrone CR, Soares R, Boucher Y, Fukumura D, Jain RK. Obesity-Induced Inflammation and Desmoplasia Promote Pancreatic Cancer Progression and Resistance to Chemotherapy. Cancer Discov. 2016 Aug; 6(8):852-69. PMID: 27246539; PMCID: PMC4972679 [Available on 08/01/17].
  15. Moreau N, Mauborgne A, Bourgoin S, Couraud PO, Romero IA, Weksler BB, Villanueva L, Pohl M, Boucher Y. Early alterations of Hedgehog signaling pathway in vascular endothelial cells after peripheral nerve injury elicit blood-nerve barrier disruption, nerve inflammation, and neuropathic pain development. Pain. 2016 Apr; 157(4):827-39. PMID: 26655733.
    View in: PubMed
  16. Dieb W, Ouachikh O, Alves S, Boucher Y, Durif F, Hafidi A. Nigrostriatal dopaminergic depletion increases static orofacial allodynia. J Headache Pain. 2016; 17:11. PMID: 26885825; PMCID: PMC4757596.
  17. Braud A, Boucher Y. The relationship between the clinical features of idiopathic burning mouth syndrome and self-perceived quality of life. J Oral Sci. 2016; 58(4):475-481. PMID: 28025430.
    View in: PubMed
  18. Tolaney SM, Boucher Y, Duda DG, Martin JD, Seano G, Ancukiewicz M, Barry WT, Goel S, Lahdenrata J, Isakoff SJ, Yeh ED, Jain SR, Golshan M, Brock J, Snuderl M, Winer EP, Krop IE, Jain RK. Role of vascular density and normalization in response to neoadjuvant bevacizumab and chemotherapy in breast cancer patients. Proc Natl Acad Sci U S A. 2015 Nov 17; 112(46):14325-30. PMID: 26578779; PMCID: PMC4655544.
  19. Molet J, Mauborgne A, Diallo M, Armand V, Geny D, Villanueva L, Boucher Y, Pohl M. Microglial Janus kinase/signal transduction and activator of transcription 3 pathway activity directly impacts astrocyte and spinal neuron characteristics. J Neurochem. 2016 Jan; 136(1):133-47. PMID: 26440453.
    View in: PubMed
  20. Ager EI, Kozin SV, Kirkpatrick ND, Seano G, Kodack DP, Askoxylakis V, Huang Y, Goel S, Snuderl M, Muzikansky A, Finkelstein DM, Dransfield DT, Devy L, Boucher Y, Fukumura D, Jain RK. Blockade of MMP14 activity in murine breast carcinomas: implications for macrophages, vessels, and radiotherapy. J Natl Cancer Inst. 2015 Apr; 107(4). PMID: 25710962; PMCID: PMC4402365.
  21. Chauhan VP, Boucher Y, Ferrone CR, Roberge S, Martin JD, Stylianopoulos T, Bardeesy N, DePinho RA, Padera TP, Munn LL, Jain RK. Compression of pancreatic tumor blood vessels by hyaluronan is caused by solid stress and not interstitial fluid pressure. Cancer Cell. 2014 Jul 14; 26(1):14-5. PMID: 25026209; PMCID: PMC4381566.
  22. Lee JJ, Perera RM, Wang H, Wu DC, Liu XS, Han S, Fitamant J, Jones PD, Ghanta KS, Kawano S, Nagle JM, Deshpande V, Boucher Y, Kato T, Chen JK, Willmann JK, Bardeesy N, Beachy PA. Stromal response to Hedgehog signaling restrains pancreatic cancer progression. Proc Natl Acad Sci U S A. 2014 Jul 29; 111(30):E3091-100. PMID: 25024225; PMCID: PMC4121834.
  23. Hong TS, Ryan DP, Borger DR, Blaszkowsky LS, Yeap BY, Ancukiewicz M, Deshpande V, Shinagare S, Wo JY, Boucher Y, Wadlow RC, Kwak EL, Allen JN, Clark JW, Zhu AX, Ferrone CR, Mamon HJ, Adams J, Winrich B, Grillo T, Jain RK, DeLaney TF, Fernandez-del Castillo C, Duda DG. A phase 1/2 and biomarker study of preoperative short course chemoradiation with proton beam therapy and capecitabine followed by early surgery for resectable pancreatic ductal adenocarcinoma. Int J Radiat Oncol Biol Phys. 2014 Jul 15; 89(4):830-8. PMID: 24867540; PMCID: PMC4791180.
  24. Caron G, Azérad J, Faure MO, Machtou P, Boucher Y. Use of a new retrograde filling material (Biodentine) for endodontic surgery: two case reports. Int J Oral Sci. 2014 Dec; 6(4):250-3. PMID: 24810806.
    View in: PubMed
  25. Schwabl P, Payer BA, Grahovac J, Klein S, Horvatits T, Mitterhauser M, Stift J, Boucher Y, Trebicka J, Trauner M, Angermayr B, Fuhrmann V, Reiberger T, Peck-Radosavljevic M. Pioglitazone decreases portosystemic shunting by modulating inflammation and angiogenesis in cirrhotic and non-cirrhotic portal hypertensive rats. J Hepatol. 2014 Jun; 60(6):1135-42. PMID: 24530596.
    View in: PubMed
  26. Boucher Y, Simons CT, Carstens MI, Carstens E. Effects of gustatory nerve transection and/or ovariectomy on oral capsaicin avoidance in rats. Pain. 2014 Apr; 155(4):814-20. PMID: 24468031; PMCID: PMC3967852.
  27. Dauvergne C, Molet J, Reaux-Le Goazigo A, Mauborgne A, Mélik-Parsadaniantz S, Boucher Y, Pohl M. Implication of the chemokine CCL2 in trigeminal nociception and traumatic neuropathic orofacial pain. Eur J Pain. 2014 Mar; 18(3):360-75. PMID: 23918315.
    View in: PubMed
  28. Boucher Y, Felizardo R, Klein AH, Carstens MI, Carstens E. Gustatory modulation of the responses of trigeminal subnucleus caudalis neurons to noxious stimulation of the tongue in rats. Eur J Neurosci. 2013 Sep; 38(6):2812-22. PMID: 23802589; PMCID: PMC4591004.
  29. Boucher Y, Carstens MI, Sawyer CM, Zanotto KL, Merrill AW, Carstens E. Capsaicin avoidance as a measure of chemical hyperalgesia in orofacial nerve injury models. Neurosci Lett. 2013 May 24; 543:37-41. PMID: 23562513; PMCID: PMC3649860.
  30. Chauhan VP, Martin JD, Liu H, Lacorre DA, Jain SR, Kozin SV, Stylianopoulos T, Mousa AS, Han X, Adstamongkonkul P, Popovic Z, Huang P, Bawendi MG, Boucher Y, Jain RK. Angiotensin inhibition enhances drug delivery and potentiates chemotherapy by decompressing tumour blood vessels. Nat Commun. 2013; 4:2516. PMID: 24084631; PMCID: PMC3806395.
  31. Braud A, Touré B, Agbo-Godeau S, Descroix V, Boucher Y. Characteristics of pain assessed with visual analog scale and questionnaire in burning mouth syndrome patients: a pilot study. J Orofac Pain. 2013; 27(3):235-42. PMID: 23882456.
    View in: PubMed
  32. Touré B, Boucher Y. Acute apical periodontitis and vertical root fracture of the same tooth: a case report. J Oral Sci. 2013; 55(2):187-90. PMID: 23748460.
    View in: PubMed
  33. Liu J, Liao S, Diop-Frimpong B, Chen W, Goel S, Naxerova K, Ancukiewicz M, Boucher Y, Jain RK, Xu L. TGF-ß blockade improves the distribution and efficacy of therapeutics in breast carcinoma by normalizing the tumor stroma. Proc Natl Acad Sci U S A. 2012 Oct 09; 109(41):16618-23. PMID: 22996328; PMCID: PMC3478596.
  34. Stylianopoulos T, Martin JD, Chauhan VP, Jain SR, Diop-Frimpong B, Bardeesy N, Smith BL, Ferrone CR, Hornicek FJ, Boucher Y, Munn LL, Jain RK. Causes, consequences, and remedies for growth-induced solid stress in murine and human tumors. Proc Natl Acad Sci U S A. 2012 Sep 18; 109(38):15101-8. PMID: 22932871; PMCID: PMC3458380.
  35. Zerari-Mailly F, Braud A, Davido N, Touré B, Azérad J, Boucher Y. Glutamate control of pulpal blood flow in the incisor dental pulp of the rat. Eur J Oral Sci. 2012 Oct; 120(5):402-7. PMID: 22984997.
    View in: PubMed
  36. Raut CP, Boucher Y, Duda DG, Morgan JA, Quek R, Ancukiewicz M, Lahdenranta J, Eder JP, Demetri GD, Jain RK. Effects of sorafenib on intra-tumoral interstitial fluid pressure and circulating biomarkers in patients with refractory sarcomas (NCI protocol 6948). PLoS One. 2012; 7(2):e26331. PMID: 22347360; PMCID: PMC3274514.
  37. Tse JM, Cheng G, Tyrrell JA, Wilcox-Adelman SA, Boucher Y, Jain RK, Munn LL. Mechanical compression drives cancer cells toward invasive phenotype. Proc Natl Acad Sci U S A. 2012 Jan 17; 109(3):911-6. PMID: 22203958; PMCID: PMC3271885.
  38. Braud A, Vandenbeuch A, Zerari-Mailly F, Boucher Y. Dental afferents project onto gustatory neurons in the nucleus of the solitary tract. J Dent Res. 2012 Feb; 91(2):215-20. PMID: 22116981.
    View in: PubMed
  39. Touré B, Faye B, Kane AW, Lo CM, Niang B, Boucher Y. Analysis of reasons for extraction of endodontically treated teeth: a prospective study. J Endod. 2011 Nov; 37(11):1512-5. PMID: 22000453.
    View in: PubMed
  40. Goel S, Duda DG, Xu L, Munn LL, Boucher Y, Fukumura D, Jain RK. Normalization of the vasculature for treatment of cancer and other diseases. Physiol Rev. 2011 Jul; 91(3):1071-121. PMID: 21742796; PMCID: PMC3258432.
  41. Horowitz NS, Penson RT, Duda DG, di Tomaso E, Boucher Y, Ancukiewicz M, Cohen KS, Berlin S, Krasner CN, Moses MA, Jain RK. Safety, Efficacy, and Biomarker Exploration in a Phase II Study of Bevacizumab, Oxaliplatin, and Gemcitabine in Recurrent Müllerian Carcinoma. Clin Ovarian Cancer Other Gynecol Malig. 2011 Jun; 4(1):26-33. PMID: 21833345.
    View in: PubMed
  42. Perentes JY, Kirkpatrick ND, Nagano S, Smith EY, Shaver CM, Sgroi D, Garkavtsev I, Munn LL, Jain RK, Boucher Y. Cancer cell-associated MT1-MMP promotes blood vessel invasion and distant metastasis in triple-negative mammary tumors. Cancer Res. 2011 Jul 01; 71(13):4527-38. PMID: 21571860.
    View in: PubMed
  43. Davido N, Rigolet A, Kerner S, Gruffaz F, Boucher Y. Case of Ewing's sarcoma misdiagnosed as a periapical lesion of maxillary incisor. J Endod. 2011 Feb; 37(2):259-64. PMID: 21238814.
    View in: PubMed
  44. Diop-Frimpong B, Chauhan VP, Krane S, Boucher Y, Jain RK. Losartan inhibits collagen I synthesis and improves the distribution and efficacy of nanotherapeutics in tumors. Proc Natl Acad Sci U S A. 2011 Feb 15; 108(7):2909-14. PMID: 21282607; PMCID: PMC3041115.
  45. Chauhan VP, Stylianopoulos T, Boucher Y, Jain RK. Delivery of molecular and nanoscale medicine to tumors: transport barriers and strategies. Annu Rev Chem Biomol Eng. 2011; 2:281-98. PMID: 22432620.
    View in: PubMed
  46. Braud A, Boucher Y, Zerari-Mailly F. Vesicular glutamate transporters localization in the rat lingual papillae. Neuroreport. 2010 Jan 06; 21(1):64-7. PMID: 19952853.
    View in: PubMed
  47. Felizardo R, Boucher Y, Braud A, Carstens E, Dauvergne C, Zerari-Mailly F. Trigeminal projections on gustatory neurons of the nucleus of the solitary tract: a double-label strategy using electrical stimulation of the chorda tympani and tracer injection in the lingual nerve. Brain Res. 2009 Sep 08; 1288:60-8. PMID: 19595675.
    View in: PubMed
  48. Chauhan VP, Lanning RM, Diop-Frimpong B, Mok W, Brown EB, Padera TP, Boucher Y, Jain RK. Multiscale measurements distinguish cellular and interstitial hindrances to diffusion in vivo. Biophys J. 2009 Jul 08; 97(1):330-6. PMID: 19580771; PMCID: PMC2711376.
  49. Raliou M, Wiencis A, Pillias AM, Planchais A, Eloit C, Boucher Y, Trotier D, Montmayeur JP, Faurion A. Nonsynonymous single nucleotide polymorphisms in human tas1r1, tas1r3, and mGluR1 and individual taste sensitivity to glutamate. Am J Clin Nutr. 2009 Sep; 90(3):789S-799S. PMID: 19571223.
    View in: PubMed
  50. Willett CG, Duda DG, di Tomaso E, Boucher Y, Ancukiewicz M, Sahani DV, Lahdenranta J, Chung DC, Fischman AJ, Lauwers GY, Shellito P, Czito BG, Wong TZ, Paulson E, Poleski M, Vujaskovic Z, Bentley R, Chen HX, Clark JW, Jain RK. Efficacy, safety, and biomarkers of neoadjuvant bevacizumab, radiation therapy, and fluorouracil in rectal cancer: a multidisciplinary phase II study. J Clin Oncol. 2009 Jun 20; 27(18):3020-6. PMID: 19470921; PMCID: PMC2702234.
  51. Mok W, Stylianopoulos T, Boucher Y, Jain RK. Mathematical modeling of herpes simplex virus distribution in solid tumors: implications for cancer gene therapy. Clin Cancer Res. 2009 Apr 01; 15(7):2352-60. PMID: 19318482; PMCID: PMC2872130.
  52. Perentes JY, McKee TD, Ley CD, Mathiew H, Dawson M, Padera TP, Munn LL, Jain RK, Boucher Y. In vivo imaging of extracellular matrix remodeling by tumor-associated fibroblasts. Nat Methods. 2009 Feb; 6(2):143-5. PMID: 19151720; PMCID: PMC2877598.
  53. Raliou M, Boucher Y, Wiencis A, Bézirard V, Pernollet JC, Trotier D, Faurion A, Montmayeur JP. Tas1R1-Tas1R3 taste receptor variants in human fungiform papillae. Neurosci Lett. 2009 Feb 27; 451(3):217-21. PMID: 19146926.
    View in: PubMed
  54. Touré B, Kane AW, Mbodji EB, Ndiaye C, Bane K, Gaye F, Boucher Y. [Prevalence of fixed prosthesis-related periodontitis in Senegal]. Odontostomatol Trop. 2008 Sep; 31(123):11-6. PMID: 19266845.
    View in: PubMed
  55. Willett CG, Duda DG, Xu L, diTomaso E, Boucher Y, Czito B, Ancukiewicz M, Clark J, Carroll M, Lauwers G, Jain RK. Correlation of blood and physiologic markers with effect of bevacizumab (BV) with chemoradiation therapy in rectal cancer (RC). J Clin Oncol. 2008 May 20; 26(15_suppl):4096. PMID: 27949464.
    View in: PubMed
  56. Nagano S, Perentes JY, Jain RK, Boucher Y. Cancer cell death enhances the penetration and efficacy of oncolytic herpes simplex virus in tumors. Cancer Res. 2008 May 15; 68(10):3795-802. PMID: 18483263; PMCID: PMC2871708.
  57. Mbaye M, Touré B, Kane AW, Leye F, Bane K, Boucher Y. [Radiographic study of the canal anatomy of mandibular premolars in a Senegalese population]. Dakar Med. 2008; 53(3):267-71. PMID: 19626801.
    View in: PubMed
  58. Mok W, Boucher Y, Jain RK. Matrix metalloproteinases-1 and -8 improve the distribution and efficacy of an oncolytic virus. Cancer Res. 2007 Nov 15; 67(22):10664-8. PMID: 18006807.
    View in: PubMed
  59. Touré B, Kane AW, Sarr M, Ngom CT, Boucher Y. Prevalence and technical quality of root fillings in Dakar, Senegal. Int Endod J. 2008 Jan; 41(1):41-9. PMID: 18005046.
    View in: PubMed
  60. Kozin SV, Winkler F, Garkavtsev I, Hicklin DJ, Jain RK, Boucher Y. Human tumor xenografts recurring after radiotherapy are more sensitive to anti-vascular endothelial growth factor receptor-2 treatment than treatment-naive tumors. Cancer Res. 2007 Jun 01; 67(11):5076-82. PMID: 17545583.
    View in: PubMed
  61. Ogawa K, Boucher Y, Kashiwagi S, Fukumura D, Chen D, Gerweck LE. Influence of tumor cell and stroma sensitivity on tumor response to radiation. Cancer Res. 2007 May 01; 67(9):4016-21. PMID: 17483312.
    View in: PubMed
  62. Willett CG, Duda DG, di Tomaso E, Boucher Y, Czito BG, Vujaskovic Z, Vlahovic G, Bendell J, Cohen KS, Hurwitz HI, Bentley R, Lauwers GY, Poleski M, Wong TZ, Paulson E, Ludwig KA, Jain RK. Complete pathological response to bevacizumab and chemoradiation in advanced rectal cancer. Nat Clin Pract Oncol. 2007 May; 4(5):316-21. PMID: 17464339; PMCID: PMC2686127.
  63. Lawenda BD, Smith DE, Xu L, Niemierko A, Silverstein JR, Boucher Y, Kashiwagi S, Held KD, Jain RK, Loeffler JS, Eisenberg DM, Blumberg JB. Do the dietary supplements epigallocatechin gallate or vitamin e cause a radiomodifying response on tumors in vivo? A pilot study with murine breast carcinoma. J Soc Integr Oncol. 2007; 5(1):11-7. PMID: 17309809.
    View in: PubMed
  64. Touré B, Kane AW, Diouf A, Faye B, Boucher Y. Preoperative pain and medications used in emergency patients with irreversible acute pulpitis or acute apical periodontitis: a prospective comparative study. J Orofac Pain. 2007; 21(4):303-8. PMID: 18018991.
    View in: PubMed
  65. Boucher Y, Berteretche MV, Farhang F, Arvy MP, Azérad J, Faurion A. Taste deficits related to dental deafferentation: an electrogustometric study in humans. Eur J Oral Sci. 2006 Dec; 114(6):456-64. PMID: 17184225.
    View in: PubMed
  66. Willett CG, Kozin SV, Duda DG, di Tomaso E, Kozak KR, Boucher Y, Jain RK. Combined vascular endothelial growth factor-targeted therapy and radiotherapy for rectal cancer: theory and clinical practice. Semin Oncol. 2006 Oct; 33(5 Suppl 10):S35-40. PMID: 17145523; PMCID: PMC2686124.
  67. Simons CT, Boucher Y, Carstens MI, Carstens E. Nicotine suppression of gustatory responses of neurons in the nucleus of the solitary tract. J Neurophysiol. 2006 Oct; 96(4):1877-86. PMID: 16837661.
    View in: PubMed
  68. McKee TD, Grandi P, Mok W, Alexandrakis G, Insin N, Zimmer JP, Bawendi MG, Boucher Y, Breakefield XO, Jain RK. Degradation of fibrillar collagen in a human melanoma xenograft improves the efficacy of an oncolytic herpes simplex virus vector. Cancer Res. 2006 Mar 01; 66(5):2509-13. PMID: 16510565.
    View in: PubMed
  69. Willett CG, Boucher Y, Duda DG, di Tomaso E, Munn LL, Tong RT, Kozin SV, Petit L, Jain RK, Chung DC, Sahani DV, Kalva SP, Cohen KS, Scadden DT, Fischman AJ, Clark JW, Ryan DP, Zhu AX, Blaszkowsky LS, Shellito PC, Mino-Kenudson M, Lauwers GY. Surrogate markers for antiangiogenic therapy and dose-limiting toxicities for bevacizumab with radiation and chemotherapy: continued experience of a phase I trial in rectal cancer patients. J Clin Oncol. 2005 Nov 01; 23(31):8136-9. PMID: 16258121.
    View in: PubMed
  70. Demou ZN, Awad M, McKee T, Perentes JY, Wang X, Munn LL, Jain RK, Boucher Y. Lack of telopeptides in fibrillar collagen I promotes the invasion of a metastatic breast tumor cell line. Cancer Res. 2005 Jul 01; 65(13):5674-82. PMID: 15994941.
    View in: PubMed
  71. Taghian AG, Abi-Raad R, Assaad SI, Casty A, Ancukiewicz M, Yeh E, Molokhia P, Attia K, Sullivan T, Kuter I, Boucher Y, Powell SN. Paclitaxel decreases the interstitial fluid pressure and improves oxygenation in breast cancers in patients treated with neoadjuvant chemotherapy: clinical implications. J Clin Oncol. 2005 Mar 20; 23(9):1951-61. PMID: 15774788.
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  72. Garkavtsev I, Boucher Y. An intact ING1-P53 pathway can potentiate the cytotoxic effects of taxol. Cancer Biol Ther. 2005 Jan; 4(1):48-9. PMID: 15711122.
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  73. Tong RT, Boucher Y, Kozin SV, Winkler F, Hicklin DJ, Jain RK. Vascular normalization by vascular endothelial growth factor receptor 2 blockade induces a pressure gradient across the vasculature and improves drug penetration in tumors. Cancer Res. 2004 Jun 01; 64(11):3731-6. PMID: 15172975.
    View in: PubMed
  74. Brown EB, Boucher Y, Nasser S, Jain RK. Measurement of macromolecular diffusion coefficients in human tumors. Microvasc Res. 2004 May; 67(3):231-6. PMID: 15121448.
    View in: PubMed
  75. Willett CG, Boucher Y, di Tomaso E, Duda DG, Munn LL, Tong RT, Chung DC, Sahani DV, Kalva SP, Kozin SV, Mino M, Cohen KS, Scadden DT, Hartford AC, Fischman AJ, Clark JW, Ryan DP, Zhu AX, Blaszkowsky LS, Chen HX, Shellito PC, Lauwers GY, Jain RK. Direct evidence that the VEGF-specific antibody bevacizumab has antivascular effects in human rectal cancer. Nat Med. 2004 Feb; 10(2):145-7. PMID: 14745444; PMCID: PMC2693485.
  76. Alexandrakis G, Brown EB, Tong RT, McKee TD, Campbell RB, Boucher Y, Jain RK. Two-photon fluorescence correlation microscopy reveals the two-phase nature of transport in tumors. Nat Med. 2004 Feb; 10(2):203-7. PMID: 14716306.
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  77. Padera TP, Boucher Y, Jain RK. Correspondence re: S. Maula et al., intratumoral lymphatics are essential for the metastatic spread and prognosis in squamous cell carcinoma of the head and neck. Cancer Res., 63: 1920-1926, 2003. Cancer Res. 2003 Dec 01; 63(23):8555-6; author reply 8558. PMID: 14679026.
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  78. Znati CA, Rosenstein M, McKee TD, Brown E, Turner D, Bloomer WD, Watkins S, Jain RK, Boucher Y. Irradiation reduces interstitial fluid transport and increases the collagen content in tumors. Clin Cancer Res. 2003 Nov 15; 9(15):5508-13. PMID: 14654530.
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  79. Roose T, Netti PA, Munn LL, Boucher Y, Jain RK. Solid stress generated by spheroid growth estimated using a linear poroelasticity model. Microvasc Res. 2003 Nov; 66(3):204-12. PMID: 14609526.
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  80. Boucher Y, Simons CT, Faurion A, Azérad J, Carstens E. Trigeminal modulation of gustatory neurons in the nucleus of the solitary tract. Brain Res. 2003 May 30; 973(2):265-74. PMID: 12738070.
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  81. Brown E, McKee T, diTomaso E, Pluen A, Seed B, Boucher Y, Jain RK. Dynamic imaging of collagen and its modulation in tumors in vivo using second-harmonic generation. Nat Med. 2003 Jun; 9(6):796-800. PMID: 12754503.
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  82. Simons CT, Boucher Y, Carstens MI, Carstens E. Lack of quinine-evoked activity in rat trigeminal subnucleus caudalis. Chem Senses. 2003 Mar; 28(3):253-9. PMID: 12714448.
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  83. Simons CT, Boucher Y, Carstens E. Suppression of central taste transmission by oral capsaicin. J Neurosci. 2003 Feb 01; 23(3):978-85. PMID: 12574427.
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  84. Boucher Y, Simons CT, Cuellar JM, Jung SW, Carstens MI, Carstens E. Activation of brain stem neurons by irritant chemical stimulation of the throat assessed by c-fos immunohistochemistry. Exp Brain Res. 2003 Jan; 148(2):211-8. PMID: 12520409.
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  85. Ramanujan S, Pluen A, McKee TD, Brown EB, Boucher Y, Jain RK. Diffusion and convection in collagen gels: implications for transport in the tumor interstitium. Biophys J. 2002 Sep; 83(3):1650-60. PMID: 12202388; PMCID: PMC1302261.
  86. Padera TP, Kadambi A, di Tomaso E, Carreira CM, Brown EB, Boucher Y, Choi NC, Mathisen D, Wain J, Mark EJ, Munn LL, Jain RK. Lymphatic metastasis in the absence of functional intratumor lymphatics. Science. 2002 Jun 07; 296(5574):1883-6. PMID: 11976409.
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  87. Hofman S, Azérad J, Boucher Y. Effects of excitatory amino acid receptor antagonists on pulpal blood flow of the rat mandibular incisor. J Dent Res. 2002 Apr; 81(4):253-8. PMID: 12097309.
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  88. Koike C, McKee TD, Pluen A, Ramanujan S, Burton K, Munn LL, Boucher Y, Jain RK. Solid stress facilitates spheroid formation: potential involvement of hyaluronan. Br J Cancer. 2002 Mar 18; 86(6):947-53. PMID: 11953828; PMCID: PMC2364140.
  89. Boucher Y, Matossian L, Rilliard F, Machtou P. Radiographic evaluation of the prevalence and technical quality of root canal treatment in a French subpopulation. Int Endod J. 2002 Mar; 35(3):229-38. PMID: 11985674.
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  90. Mouta Carreira C, Nasser SM, di Tomaso E, Padera TP, Boucher Y, Tomarev SI, Jain RK. LYVE-1 is not restricted to the lymph vessels: expression in normal liver blood sinusoids and down-regulation in human liver cancer and cirrhosis. Cancer Res. 2001 Nov 15; 61(22):8079-84. PMID: 11719431.
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  91. Davies Cde L, Melder RJ, Munn LL, Mouta-Carreira C, Jain RK, Boucher Y. Decorin inhibits endothelial migration and tube-like structure formation: role of thrombospondin-1. Microvasc Res. 2001 Jul; 62(1):26-42. PMID: 11421658.
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  92. Boucher Y, Nesbø CL, Doolittle WF. Microbial genomes: dealing with diversity. Curr Opin Microbiol. 2001 Jun; 4(3):285-9. PMID: 11378480.
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  93. Pluen A, Boucher Y, Ramanujan S, McKee TD, Gohongi T, di Tomaso E, Brown EB, Izumi Y, Campbell RB, Berk DA, Jain RK. Role of tumor-host interactions in interstitial diffusion of macromolecules: cranial vs. subcutaneous tumors. Proc Natl Acad Sci U S A. 2001 Apr 10; 98(8):4628-33. PMID: 11274375; PMCID: PMC31885.
  94. Boucher Y, Hofman S, Joulin Y, Azérad J. Effects of BP 2-94, a selective H(3)-receptor agonist, on blood flow and vascular permeability of the rat mandibular incisor pulp. Arch Oral Biol. 2001 Jan; 46(1):83-92. PMID: 11163599.
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  95. Kozin SV, Boucher Y, Hicklin DJ, Bohlen P, Jain RK, Suit HD. Vascular endothelial growth factor receptor-2-blocking antibody potentiates radiation-induced long-term control of human tumor xenografts. Cancer Res. 2001 Jan 01; 61(1):39-44. PMID: 11196192.
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  96. Lee CG, Heijn M, di Tomaso E, Griffon-Etienne G, Ancukiewicz M, Koike C, Park KR, Ferrara N, Jain RK, Suit HD, Boucher Y. Anti-Vascular endothelial growth factor treatment augments tumor radiation response under normoxic or hypoxic conditions. Cancer Res. 2000 Oct 01; 60(19):5565-70. PMID: 11034104.
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  97. Stohrer M, Boucher Y, Stangassinger M, Jain RK. Oncotic pressure in solid tumors is elevated. Cancer Res. 2000 Aug 01; 60(15):4251-5. PMID: 10945638.
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  98. Boucher Y, Doolittle WF. The role of lateral gene transfer in the evolution of isoprenoid biosynthesis pathways. Mol Microbiol. 2000 Aug; 37(4):703-16. PMID: 10972794.
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  99. Briand L, Huet J, Perez V, Lenoir G, Nespoulous C, Boucher Y, Trotier D, Pernollet JC. Odorant and pheromone binding by aphrodisin, a hamster aphrodisiac protein. FEBS Lett. 2000 Jul 07; 476(3):179-85. PMID: 10913609.
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  100. Sauveur G, Sobel M, Boucher Y. Utilization of gutta-percha for retrograde root fillings. Endod Dent Traumatol. 2000 Jun; 16(3):128-31. PMID: 11202869.
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  101. Boucher Y, Sobel M, Sauveur G. Persistent pain related to root canal filling and apical fenestration: a case report. J Endod. 2000 Apr; 26(4):242-4. PMID: 11199728.
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  102. Swartz MA, Kaipainen A, Netti PA, Brekken C, Boucher Y, Grodzinsky AJ, Jain RK. Mechanics of interstitial-lymphatic fluid transport: theoretical foundation and experimental validation. J Biomech. 1999 Dec; 32(12):1297-307. PMID: 10569708.
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  103. Gohongi T, Fukumura D, Boucher Y, Yun CO, Soff GA, Compton C, Todoroki T, Jain RK. Tumor-host interactions in the gallbladder suppress distal angiogenesis and tumor growth: involvement of transforming growth factor beta1. Nat Med. 1999 Oct; 5(10):1203-8. PMID: 10502827.
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  104. Griffon-Etienne G, Boucher Y, Brekken C, Suit HD, Jain RK. Taxane-induced apoptosis decompresses blood vessels and lowers interstitial fluid pressure in solid tumors: clinical implications. Cancer Res. 1999 Aug 01; 59(15):3776-82. PMID: 10446995.
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  105. Sauveur G, Roth F, Sobel M, Boucher Y. The control of haemorrhage at the operative site during periradicular surgery. Int Endod J. 1999 May; 32(3):225-8. PMID: 10530211.
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  106. Netti PA, Hamberg LM, Babich JW, Kierstead D, Graham W, Hunter GJ, Wolf GL, Fischman A, Boucher Y, Jain RK. Enhancement of fluid filtration across tumor vessels: implication for delivery of macromolecules. Proc Natl Acad Sci U S A. 1999 Mar 16; 96(6):3137-42. PMID: 10077650; PMCID: PMC15908.
  107. Boucher Y, Brekken C, Netti PA, Baxter LT, Jain RK. Intratumoral infusion of fluid: estimation of hydraulic conductivity and implications for the delivery of therapeutic agents. Br J Cancer. 1998 Dec; 78(11):1442-8. PMID: 9836476; PMCID: PMC2063228.
  108. Sauveur G, Boccara E, Colon P, Sobel M, Boucher Y. A photoelastimetric analysis of stress induced by root-end resection. J Endod. 1998 Nov; 24(11):740-3. PMID: 9855825.
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  109. Sauveur G, Boucher Y. A teaching model for endodontic surgery. Int Endod J. 1998 Mar; 31(2):133-6. PMID: 9868941.
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  110. Griffon-Etienne G, Boucher Y, Jain RK, Suit HD. Effects of needle insertion in tumors on interstitial fluid pressure. Microvasc Res. 1997 Sep; 54(2):174-7. PMID: 9327388.
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  111. Sauveur G, Sobel M, Boucher Y. Surgical treatment of a lateroradicular lesion on an invaginated lateral incisor (dens in dente). Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1997 Jun; 83(6):703-6. PMID: 9195627.
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  112. Sauveur G, Roth F, Sobel M, Boucher Y. Surgical treatment of a periradicular lesion on an invaginated maxillary lateral incisor (dens in dente). Int Endod J. 1997 Mar; 30(2):145-9. PMID: 10332249.
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  113. Boucher Y, Salehi H, Witwer B, Harsh GR, Jain RK. Interstitial fluid pressure in intracranial tumours in patients and in rodents. Br J Cancer. 1997; 75(6):829-36. PMID: 9062403; PMCID: PMC2063404.
  114. Boucher Y, Leunig M, Jain RK. Tumor angiogenesis and interstitial hypertension. Cancer Res. 1996 Sep 15; 56(18):4264-6. PMID: 8797602.
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  115. Kristensen CA, Nozue M, Boucher Y, Jain RK. Reduction of interstitial fluid pressure after TNF-alpha treatment of three human melanoma xenografts. Br J Cancer. 1996 Aug; 74(4):533-6. PMID: 8761366; PMCID: PMC2074665.
  116. Netti PA, Roberge S, Boucher Y, Baxter LT, Jain RK. Effect of transvascular fluid exchange on pressure-flow relationship in tumors: a proposed mechanism for tumor blood flow heterogeneity. Microvasc Res. 1996 Jul; 52(1):27-46. PMID: 8812751.
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  117. Hartmann A, Azérad J, Boucher Y. Environmental effects on laser Doppler pulpal blood-flow measurements in man. Arch Oral Biol. 1996 Apr; 41(4):333-9. PMID: 8771324.
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  118. Znati CA, Rosenstein M, Boucher Y, Epperly MW, Bloomer WD, Jain RK. Effect of radiation on interstitial fluid pressure and oxygenation in a human tumor xenograft. Cancer Res. 1996 Mar 01; 56(5):964-68. PMID: 8640786.
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  119. Netti PA, Baxter LT, Boucher Y, Skalak R, Jain RK. Time-dependent behavior of interstitial fluid pressure in solid tumors: implications for drug delivery. Cancer Res. 1995 Nov 15; 55(22):5451-8. PMID: 7585615.
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  120. Zlotecki RA, Baxter LT, Boucher Y, Jain RK. Pharmacologic modification of tumor blood flow and interstitial fluid pressure in a human tumor xenograft: network analysis and mechanistic interpretation. Microvasc Res. 1995 Nov; 50(3):429-43. PMID: 8583955.
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  121. Boucher Y, Lee I, Jain RK. Lack of general correlation between interstitial fluid pressure and oxygen partial pressure in solid tumors. Microvasc Res. 1995 Sep; 50(2):175-82. PMID: 8538498.
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  122. Yuan F, Salehi HA, Boucher Y, Vasthare US, Tuma RF, Jain RK. Vascular permeability and microcirculation of gliomas and mammary carcinomas transplanted in rat and mouse cranial windows. Cancer Res. 1994 Sep 01; 54(17):4564-8. PMID: 8062241.
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  123. Lee I, Demhartner TJ, Boucher Y, Jain RK, Intaglietta M. Effect of hemodilution and resuscitation on tumor interstitial fluid pressure, blood flow, and oxygenation. Microvasc Res. 1994 Jul; 48(1):1-12. PMID: 7990716.
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  124. Lee I, Boucher Y, Demhartner TJ, Jain RK. Changes in tumour blood flow, oxygenation and interstitial fluid pressure induced by pentoxifylline. Br J Cancer. 1994 Mar; 69(3):492-6. PMID: 8123479; PMCID: PMC1968875.
  125. Kristjansen PE, Boucher Y, Jain RK. Dexamethasone reduces the interstitial fluid pressure in a human colon adenocarcinoma xenograft. Cancer Res. 1993 Oct 15; 53(20):4764-6. PMID: 8402656.
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  126. Boucher Y, Pollin B, Azérad J. Microinfusions of excitatory amino acid antagonists into the trigeminal sensory complex antagonize the jaw opening reflex in freely moving rats. Brain Res. 1993 Jun 18; 614(1-2):155-63. PMID: 8102311.
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  127. Zlotecki RA, Boucher Y, Lee I, Baxter LT, Jain RK. Effect of angiotensin II induced hypertension on tumor blood flow and interstitial fluid pressure. Cancer Res. 1993 Jun 01; 53(11):2466-8. PMID: 8495405.
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  128. Leunig M, Yuan F, Menger MD, Boucher Y, Goetz AE, Messmer K, Jain RK. Angiogenesis, microvascular architecture, microhemodynamics, and interstitial fluid pressure during early growth of human adenocarcinoma LS174T in SCID mice. Cancer Res. 1992 Dec 01; 52(23):6553-60. PMID: 1384965.
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  129. Less JR, Posner MC, Boucher Y, Borochovitz D, Wolmark N, Jain RK. Interstitial hypertension in human breast and colorectal tumors. Cancer Res. 1992 Nov 15; 52(22):6371-4. PMID: 1423283.
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  130. Boucher Y, Jain RK. Microvascular pressure is the principal driving force for interstitial hypertension in solid tumors: implications for vascular collapse. Cancer Res. 1992 Sep 15; 52(18):5110-4. PMID: 1516068.
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  131. Lee I, Boucher Y, Jain RK. Nicotinamide can lower tumor interstitial fluid pressure: mechanistic and therapeutic implications. Cancer Res. 1992 Jun 01; 52(11):3237-40. PMID: 1534273.
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  132. Azérad J, Boucher Y, Pollin B. [Demonstration of glutamate in primary sensory trigeminal neurons innervating dental pulp in rats]. C R Acad Sci III. 1992; 314(10):469-75. PMID: 1521166.
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  133. Roh HD, Boucher Y, Kalnicki S, Buchsbaum R, Bloomer WD, Jain RK. Interstitial hypertension in carcinoma of uterine cervix in patients: possible correlation with tumor oxygenation and radiation response. Cancer Res. 1991 Dec 15; 51(24):6695-8. PMID: 1742744.
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  134. Boucher Y, Kirkwood JM, Opacic D, Desantis M, Jain RK. Interstitial hypertension in superficial metastatic melanomas in humans. Cancer Res. 1991 Dec 15; 51(24):6691-4. PMID: 1742743.
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  135. Boucher Y, Baxter LT, Jain RK. Interstitial pressure gradients in tissue-isolated and subcutaneous tumors: implications for therapy. Cancer Res. 1990 Aug 01; 50(15):4478-84. PMID: 2369726.
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  136. Roberge S, Boucher Y, Roy PE. Transient ultrastructural variations of pulmonary lymphatic capillaries during the respiratory cycle of the rat lung. Anat Rec. 1985 Dec; 213(4):551-9. PMID: 4083535.
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  137. Boucher Y, Roberge S, Roy PE. Ultrastructural comparative study on lymphatic capillaries of the subendocardium, myocardium, and subepicardium of the heart left ventricle. Microvasc Res. 1985 May; 29(3):305-19. PMID: 3999989.
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