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Jamil Azzi, M.D.

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2009 - 2010
Amgen Nephrology Award
ASE Young Innovator Award
2013 - 2014
American Society of Transplantation Basic Science Award
2013 - 2018
American Heart Association FTF Transition Award
American Society of Transplantation Community of Basic Scientists Award
2016 - 2019
Innovative Basic Science Award of the American Diabetes Association

The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01AI134842 (AZZI, JAMIL) Dec 18, 2017 - Nov 30, 2022
    The novel role of the immunoproteasome subunit LMP7 in allo-immunity and T cell exhaustion
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Magee CN, Murakami N, Borges TJ, Shimizu T, Safa K, Ohori S, Cai S, Uffing A, Azzi J, Elyaman W, Charbonnier LM, Liu K, Toprak D, Visner G, Chatila TA, Siebel CW, Najafian N, Riella LV. Notch-1 Inhibition Promotes Immune Regulation in Transplantation via Treg-Dependent Mechanisms. Circulation. 2019 Jul 03. PMID: 31266349.
  2. Uffing A, Hidalgo LG, McMullan C, Perry J, Milford EL, Murakami N, Yeung MY, Guleria I, Wood IG, Akalin E, Azzi J, Chandraker AK, Riella LV. Preformed Donor-specific Antibodies Against HLA Class II and Graft Outcomes in Deceased-donor Kidney Transplantation. Transplant Direct. 2019 May; 5(5):e446. PMID: 31165081.
  3. Azzi J, Alegre ML. Outstanding questions in transplantation: An introduction to this minireview series. Am J Transplant. 2019 Mar 23. PMID: 30903734.
  4. Allos H, Al Dulaijan BS, Choi J, Azzi J. Regulatory T Cells for More Targeted Immunosuppressive Therapies. Clin Lab Med. 2019 03; 39(1):1-13. PMID: 30709499.
    Citations:    Fields:    
  5. Choi J, Bano A, Azzi J. Biomarkers in Solid Organ Transplantation. Clin Lab Med. 2019 03; 39(1):73-85. PMID: 30709510.
    Citations:    Fields:    
  6. Ordikhani F, Uehara M, Kasinath V, Dai L, Eskandari SK, Bahmani B, Yonar M, Azzi JR, Haik Y, Sage PT, Murphy GF, Annabi N, Schatton T, Guleria I, Abdi R. Targeting antigen-presenting cells by anti-PD-1 nanoparticles augments antitumor immunity. JCI Insight. 2018 10 18; 3(20). PMID: 30333312.
    Citations:    Fields:    
  7. Bahmani B, Uehara M, Jiang L, Ordikhani F, Banouni N, Ichimura T, Solhjou Z, Furtmüller GJ, Brandacher G, Alvarez D, von Andrian UH, Uchimura K, Xu Q, Vohra I, Yilmam OA, Haik Y, Azzi J, Kasinath V, Bromberg JS, McGrath MM, Abdi R. Targeted delivery of immune therapeutics to lymph nodes prolongs cardiac allograft survival. J Clin Invest. 2018 Nov 01; 128(11):4770-4786. PMID: 30277476.
    Citations:    Fields:    
  8. Borges TJ, Murakami N, Machado FD, Murshid A, Lang BJ, Lopes RL, Bellan LM, Uehara M, Antunes KH, Pérez-Saéz MJ, Birrane G, Vianna P, Gonçalves JIB, Zanin RF, Azzi J, Abdi R, Ishido S, Shin JS, Souza APD, Calderwood SK, Riella LV, Bonorino C. March1-dependent modulation of donor MHC II on CD103+ dendritic cells mitigates alloimmunity. Nat Commun. 2018 08 28; 9(1):3482. PMID: 30154416.
    Citations:    Fields:    Translation:AnimalsCells
  9. Kawano Y, Zavidij O, Park J, Moschetta M, Kokubun K, Mouhieddine TH, Manier S, Mishima Y, Murakami N, Bustoros M, Pistofidis RS, Reidy M, Shen YJ, Rahmat M, Lukyanchykov P, Karreci ES, Tsukamoto S, Shi J, Takagi S, Huynh D, Sacco A, Tai YT, Chesi M, Bergsagel PL, Roccaro AM, Azzi J, Ghobrial IM. Blocking IFNAR1 inhibits multiple myeloma-driven Treg expansion and immunosuppression. J Clin Invest. 2018 Jun 01; 128(6):2487-2499. PMID: 29558366.
    Citations: 1     Fields:    
  10. Kurdi AT, Glavey SV, Bezman NA, Jhatakia A, Guerriero JL, Manier S, Moschetta M, Mishima Y, Roccaro A, Detappe A, Liu CJ, Sacco A, Huynh D, Tai YT, Robbins MD, Azzi J, Ghobrial IM. Antibody-Dependent Cellular Phagocytosis by Macrophages is a Novel Mechanism of Action of Elotuzumab. Mol Cancer Ther. 2018 07; 17(7):1454-1463. PMID: 29654064.
    Citations: 2     Fields:    
  11. Al Dulaijan BS, Mansouri A, Karnyski J, Azzi J. Regulatory T cells: from the bench to the clinic and back. Curr Opin Organ Transplant. 2018 02; 23(1):1-7. PMID: 29210727.
    Citations:    Fields:    
  12. Santos RLA, Bai L, Singh PK, Murakami N, Fan H, Zhan W, Zhu Y, Jiang X, Zhang K, Assker JP, Nathan CF, Li H, Azzi J, Lin G. Structure of human immunoproteasome with a reversible and noncompetitive inhibitor that selectively inhibits activated lymphocytes. Nat Commun. 2017 11 22; 8(1):1692. PMID: 29167449.
    Citations: 1     Fields:    Translation:HumansCells
  13. Sula Karreci E, Eskandari SK, Dotiwala F, Routray SK, Kurdi AT, Assaker JP, Luckyanchykov P, Mihali AB, Maarouf O, Borges TJ, Alkhudhayri A, Patel KR, Radwan A, Ghobrial I, McGrath M, Chandraker A, Riella LV, Elyaman W, Abdi R, Lieberman J, Azzi J. Human regulatory T cells undergo self-inflicted damage via granzyme pathways upon activation. JCI Insight. 2017 11 02; 2(21). PMID: 29093262.
    Citations:    Fields:    
  14. Safa K, Magee CN, Azzi J. A critical review of biomarkers in kidney transplantation. Curr Opin Nephrol Hypertens. 2017 11; 26(6):509-515. PMID: 28857783.
    Citations:    Fields:    Translation:Humans
  15. Park J, Lin HY, Assaker JP, Jeong S, Huang CH, Kurdi T, Lee K, Fraser K, Min C, Eskandari S, Routray S, Tannous B, Abdi R, Riella L, Chandraker A, Castro CM, Weissleder R, Lee H, Azzi JR. Integrated Kidney Exosome Analysis for the Detection of Kidney Transplant Rejection. ACS Nano. 2017 11 28; 11(11):11041-11046. PMID: 29053921.
    Citations: 2     Fields:    Translation:HumansCells
  16. Uehara M, McGrath MM, Ohori S, Solhjou Z, Banouni N, Routray S, Evans C, DiNitto JP, Elkhal A, Turka LA, Strom TB, Tullius SG, Winkler DG, Azzi J, Abdi R. Regulation of T cell alloimmunity by PI3K? and PI3Kd. Nat Commun. 2017 10 16; 8(1):951. PMID: 29038423.
    Citations: 1     Fields:    Translation:AnimalsCells
  17. Azzi J, Raimondi G, Mas V, Riella LV, Elfadawy N, Safa K, Wojciechowski D, Kanak M, Nog R, Maltzman JS, Ford ML, Pober JS, Luo XR, Rothstein D, Miller ML, Matthews D, Burlingham W, Levings M, Heeger P, Higdon L, Gill J, Gill RG, Alegre ML. The outstanding questions in transplantation: It's about time…. Am J Transplant. 2018 01; 18(1):271-272. PMID: 28758364.
    Citations:    Fields:    
  18. Eskandari SK, Seelen MAJ, Lin G, Azzi JR. The immunoproteasome: An old player with a novel and emerging role in alloimmunity. Am J Transplant. 2017 Dec; 17(12):3033-3039. PMID: 28719024.
    Citations: 3     Fields:    Translation:HumansAnimals
  19. Mallat SG, Tanios BY, Itani HS, Lotfi T, McMullan C, Gabardi S, Akl EA, Azzi JR. CMV and BKPyV Infections in Renal Transplant Recipients Receiving an mTOR Inhibitor-Based Regimen Versus a CNI-Based Regimen: A Systematic Review and Meta-Analysis of Randomized, Controlled Trials. Clin J Am Soc Nephrol. 2017 Aug 07; 12(8):1321-1336. PMID: 28576905.
    Citations: 3     Fields:    Translation:HumansCells
  20. Azzi J, Thueson L, Moore R, Abdoli R, Reijonen H, Abdi R. PI3K? Deficient NOD-Mice Are Protected from Diabetes by Restoring the Balance of Regulatory to Effector-T-Cells. PLoS One. 2017; 12(1):e0169695. PMID: 28081180.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  21. Kawano Y, Roccaro AM, Ghobrial IM, Azzi J. Multiple Myeloma and the Immune Microenvironment. Curr Cancer Drug Targets. 2017; 17(9):806-818. PMID: 28201978.
    Citations: 3     Fields:    Translation:HumansCells
  22. Sula Karreci E, Fan H, Uehara M, Mihali AB, Singh PK, Kurdi AT, Solhjou Z, Riella LV, Ghobrial I, Laragione T, Routray S, Assaker JP, Wang R, Sukenick G, Shi L, Barrat FJ, Nathan CF, Lin G, Azzi J. Brief treatment with a highly selective immunoproteasome inhibitor promotes long-term cardiac allograft acceptance in mice. Proc Natl Acad Sci U S A. 2016 12 27; 113(52):E8425-E8432. PMID: 27956634.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  23. George JA, Bashir G, Qureshi MM, Mohamed YA, Azzi J, Al-Ramadi BK, Fernández-Cabezudo MJ. Cholinergic Stimulation Prevents the Development of Autoimmune Diabetes: Evidence for the Modulation of Th17 Effector Cells via an IFN?-Dependent Mechanism. Front Immunol. 2016; 7:419. PMID: 27790217.
    Citations: 2     
  24. Riella LV, Gabardi S, Azzi J. Belatacept and Long-Term Outcomes in Kidney Transplantation. N Engl J Med. 2016 06 30; 374(26):2599-600. PMID: 27355545.
    Citations: 1     Fields:    Translation:Humans
  25. Karia PS, Azzi JR, Heher EC, Hills VM, Schmults CD. Association of Sirolimus Use With Risk for Skin Cancer in a Mixed-Organ Cohort of Solid-Organ Transplant Recipients With a History of Cancer. JAMA Dermatol. 2016 May 01; 152(5):533-40. PMID: 26792250.
    Citations: 5     Fields:    Translation:Humans
  26. Azzi J, Yin Q, Uehara M, Ohori S, Tang L, Cai K, Ichimura T, McGrath M, Maarouf O, Kefaloyianni E, Loughhead S, Petr J, Sun Q, Kwon M, Tullius S, von Andrian UH, Cheng J, Abdi R. Targeted Delivery of Immunomodulators to Lymph Nodes. Cell Rep. 2016 05 10; 15(6):1202-13. PMID: 27134176.
    Citations: 4     Fields:    Translation:Animals
  27. Borges TJ, O'Malley JT, Wo L, Murakami N, Smith B, Azzi J, Tripathi S, Lane JD, Bueno EM, Clark RA, Tullius SG, Chandraker A, Lian CG, Murphy GF, Strom TB, Pomahac B, Najafian N, Riella LV. Codominant Role of Interferon-?- and Interleukin-17-Producing T Cells During Rejection in Full Facial Transplant Recipients. Am J Transplant. 2016 07; 16(7):2158-71. PMID: 26749226.
    Citations: 4     Fields:    Translation:HumansCells
  28. Kuijten MM, Hannah Degeling M, Chen JW, Wojtkiewicz G, Waterman P, Weissleder R, Azzi J, Nicolay K, Tannous BA. Multimodal targeted high relaxivity thermosensitive liposome for in vivo imaging. Sci Rep. 2015 Nov 27; 5:17220. PMID: 26610702.
    Citations:    Fields:    Translation:HumansAnimalsCells
  29. Mounayar M, Kefaloyianni E, Smith B, Solhjou Z, Maarouf OH, Azzi J, Chabtini L, Fiorina P, Kraus M, Briddell R, Fodor W, Herrlich A, Abdi R. PI3ka and STAT1 Interplay Regulates Human Mesenchymal Stem Cell Immune Polarization. Stem Cells. 2015 Jun; 33(6):1892-901. PMID: 25753288.
    Citations: 6     Fields:    Translation:HumansCells
  30. Ben Nasr M, Vergani A, Avruch J, Liu L, Kefaloyianni E, D'Addio F, Tezza S, Corradi D, Bassi R, Valderrama-Vasquez A, Usuelli V, Kim J, Azzi J, El Essawy B, Markmann J, Abdi R, Fiorina P. Co-transplantation of autologous MSCs delays islet allograft rejection and generates a local immunoprivileged site. Acta Diabetol. 2015 Oct; 52(5):917-27. PMID: 25808641.
    Citations: 14     Fields:    Translation:AnimalsCells
  31. Azzi J, Ohori S, Ting C, Uehara M, Abdoli R, Smith BD, Safa K, Solhjou Z, Lukyanchykov P, Patel J, McGrath M, Abdi R. Serine protease inhibitor-6 differentially affects the survival of effector and memory alloreactive CD8-T cells. Am J Transplant. 2015 Jan; 15(1):234-41. PMID: 25534448.
    Citations: 4     Fields:    Translation:AnimalsCells
  32. Adesina S, Alkhudhayri A, Patel JK, Naufal M, Geara A, Azzi J. Steroid withdrawal in kidney allograft recipients. Expert Rev Clin Immunol. 2014 Sep; 10(9):1229-39. PMID: 25119423.
    Citations: 1     Fields:    Translation:HumansAnimals
  33. Grafals M, Smith B, Murakami N, Trabucco A, Hamill K, Marangos E, Gilligan H, Pomfret EA, Pomposelli JJ, Simpson MA, Azzi J, Najafian N, Riella LV. Immunophenotyping and efficacy of low dose ATG in non-sensitized kidney recipients undergoing early steroid withdrawal: a randomized pilot study. PLoS One. 2014; 9(8):e104408. PMID: 25111080.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  34. Riella LV, Safa K, Yagan J, Lee B, Azzi J, Najafian N, Abdi R, Milford E, Mah H, Gabardi S, Malek S, Tullius SG, Magee C, Chandraker A. Long-term outcomes of kidney transplantation across a positive complement-dependent cytotoxicity crossmatch. Transplantation. 2014 Jun 27; 97(12):1247-52. PMID: 24854670.
    Citations: 7     Fields:    Translation:Humans
  35. Batal I, Azzi J, Mounayar M, Abdoli R, Moore R, Lee JY, Rosetti F, Wang C, Fiorina P, Sackstein R, Ichimura T, Abdi R. The mechanisms of up-regulation of dendritic cell activity by oxidative stress. J Leukoc Biol. 2014 Aug; 96(2):283-93. PMID: 24676276.
    Citations: 4     Fields:    Translation:AnimalsCells
  36. Lewandrowski GK, Magee CN, Mounayar M, Tannous BA, Azzi J. Simultaneous in vivo monitoring of regulatory and effector T lymphocytes using secreted Gaussia luciferase, Firefly luciferase, and secreted alkaline phosphatase. Methods Mol Biol. 2014; 1098:211-27. PMID: 24166380.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  37. Azzi JR, Sayegh MH, Mallat SG. Calcineurin inhibitors: 40 years later, can't live without ... J Immunol. 2013 Dec 15; 191(12):5785-91. PMID: 24319282.
    Citations: 31     Fields:    Translation:HumansAnimalsCells
  38. Azzi J, Skartsis N, Mounayar M, Magee CN, Batal I, Ting C, Moore R, Riella LV, Ohori S, Abdoli R, Smith B, Fiorina P, Heathcote D, Bakhos T, Ashton-Rickardt PG, Abdi R. Serine protease inhibitor 6 plays a critical role in protecting murine granzyme B-producing regulatory T cells. J Immunol. 2013 Sep 01; 191(5):2319-27. PMID: 23913965.
    Citations: 10     Fields:    Translation:AnimalsCells
  39. El-Charabaty E, Geara AS, Ting C, El-Sayegh S, Azzi J. Belatacept: a new era of immunosuppression? Expert Rev Clin Immunol. 2012 Aug; 8(6):527-36. PMID: 22992146.
    Citations: 1     Fields:    Translation:HumansAnimals
  40. Tang L, Azzi J, Kwon M, Mounayar M, Tong R, Yin Q, Moore R, Skartsis N, Fan TM, Abdi R, Cheng J. Immunosuppressive Activity of Size-Controlled PEG-PLGA Nanoparticles Containing Encapsulated Cyclosporine A. J Transplant. 2012; 2012:896141. PMID: 22545201.
    Citations: 12     
  41. Azzi J, Moore RF, Elyaman W, Mounayar M, El Haddad N, Yang S, Jurewicz M, Takakura A, Petrelli A, Fiorina P, Ruckle T, Abdi R. The novel therapeutic effect of phosphoinositide 3-kinase-? inhibitor AS605240 in autoimmune diabetes. Diabetes. 2012 Jun; 61(6):1509-18. PMID: 22403300.
    Citations: 8     Fields:    Translation:AnimalsCells
  42. Ting C, Bansal V, Batal I, Mounayar M, Chabtini L, El Akiki G, Azzi J. Impairment of immune systems in diabetes. Adv Exp Med Biol. 2012; 771:62-75. PMID: 23393672.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  43. El Haddad N, Moore R, Heathcote D, Mounayar M, Azzi J, Mfarrej B, Batal I, Ting C, Atkinson M, Sayegh MH, Ashton-Rickardt PG, Abdi R. The novel role of SERPINB9 in cytotoxic protection of human mesenchymal stem cells. J Immunol. 2011 Sep 01; 187(5):2252-60. PMID: 21795594.
    Citations: 8     Fields:    Translation:HumansCells
  44. Batal I, Azzi J, El-Haddad N, Riella LV, Lunz JG, Zeevi A, Sasatomi E, Basu A, Tan H, Shapiro R, Randhawa P. Immunohistochemical markers of tissue injury in biopsies with transplant glomerulitis. Hum Pathol. 2012 Jan; 43(1):69-80. PMID: 21777946.
    Citations: 3     Fields:    Translation:Humans
  45. Riella LV, Watanabe T, Sage PT, Yang J, Yeung M, Azzi J, Vanguri V, Chandraker A, Sharpe AH, Sayegh MH, Najafian N. Essential role of PDL1 expression on nonhematopoietic donor cells in acquired tolerance to vascularized cardiac allografts. Am J Transplant. 2011 Apr; 11(4):832-40. PMID: 21401869.
    Citations: 10     Fields:    Translation:AnimalsCells
  46. Mfarrej BG, Azzi J, De Serres SA. Determination of optimal incubation time for the production of acute phase cytokines ex vivo by peripheral blood mononuclear cells from renal transplant recipients. J Immunol Methods. 2011 Mar 07; 366(1-2):119-22. PMID: 21255580.
    Citations:    Fields:    Translation:HumansCells
  47. Jurewicz M, Ueno T, Azzi J, Tanaka K, Murayama T, Yang S, Sayegh MH, Niimi M, Abdi R. Donor antioxidant strategy prolongs cardiac allograft survival by attenuating tissue dendritic cell immunogenicity(†). Am J Transplant. 2011 Feb; 11(2):348-55. PMID: 21182586.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  48. El Haddad N, Heathcote D, Moore R, Yang S, Azzi J, Mfarrej B, Atkinson M, Sayegh MH, Lee JS, Ashton-Rickardt PG, Abdi R. Mesenchymal stem cells express serine protease inhibitor to evade the host immune response. Blood. 2011 Jan 27; 117(4):1176-83. PMID: 21076046.
    Citations: 14     Fields:    Translation:AnimalsCells
  49. Jurewicz M, Yang S, Augello A, Godwin JG, Moore RF, Azzi J, Fiorina P, Atkinson M, Sayegh MH, Abdi R. Congenic mesenchymal stem cell therapy reverses hyperglycemia in experimental type 1 diabetes. Diabetes. 2010 Dec; 59(12):3139-47. PMID: 20841611.
    Citations: 43     Fields:    Translation:AnimalsCells
  50. Azzi J, Tang L, Moore R, Tong R, El Haddad N, Akiyoshi T, Mfarrej B, Yang S, Jurewicz M, Ichimura T, Lindeman N, Cheng J, Abdi R. Polylactide-cyclosporin A nanoparticles for targeted immunosuppression. FASEB J. 2010 Oct; 24(10):3927-38. PMID: 20547662.
    Citations: 19     Fields:    Translation:Animals
  51. Azzi J, Geara AS, El-Sayegh S, Abdi R. Immunological aspects of pancreatic islet cell transplantation. Expert Rev Clin Immunol. 2010 Jan; 6(1):111-24. PMID: 20383895.
    Citations: 11     Fields:    Translation:HumansAnimals
  52. Azzi J, Sayegh MH. Clinical transplantation tolerance: a myth no more, but... Am J Kidney Dis. 2009 Dec; 54(6):1005-11. PMID: 19819055.
    Citations: 2     Fields:    Translation:HumansCells
  53. Geara AS, Azzi J, Jurewicz M, Abdi R. The renin-angiotensin system: an old, newly discovered player in immunoregulation. Transplant Rev (Orlando). 2009 Jul; 23(3):151-8. PMID: 19539879.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.