Harvard Catalyst Profiles

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Matthew K Waldor, M.D., Ph.D.

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Other Positions
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Institution
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Mentoring
current student opportunities
Available: 09/01/19, Expires: 08/31/23

The student will conduct a genome-wide screen to identify pathogen or host genes that contribute to pathogenesis of diseases caused by enteric pathogens. The student will be engaged in all steps of the project from creation of mutant libraries to analyses of the big data that screens generate. Some experience in molecular biology is preferable.

Available: 10/20/18, Expires: 09/30/23

Our lab studies the biology of Vibrio cholerae, the agent of cholera, and E. coli O157, a common cause of diarrheal disease in the USA. We are using a wide range of techniques to understand how these pathogens cause disease. We study both basic questions, such as how bacterial chromosomes replicate and segregate, and more applied issues such as development of new antibiotics and vaccines for diarrheal diseases.


Research
research activities and funding
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
Most Recent  |  List All
  1. R21AI067827 (WALDOR, MATTHEW K) Feb 1, 2006 - Jan 31, 2009
    NIH
    Intestinal colonization of Enterohemorrhagic E. coil
    Role: Principal Investigator
  2. R21AI059698 (WALDOR, MATTHEW K) Apr 1, 2004 - Mar 31, 2007
    NIH
    Role of Hfq in Vibrio cholerae virulence
    Role: Principal Investigator
  3. R01AI042347 (WALDOR, MATTHEW K) Jan 1, 1998 - May 31, 2022
    NIH
    Vibrio cholerae intestinal colonization and vaccine development
    Role: Principal Investigator
  4. R37AI042347 (WALDOR, MATTHEW K) Jan 1, 1998 - May 31, 2018
    NIH
    Molecular Biology and Virulence of CTX Phage
    Role: Principal Investigator
  5. K08AI001321 (WALDOR, MATTHEW K) Aug 1, 1995 - Jul 31, 1998
    NIH
    IDENTIFICATION OF VIRULENCE GENES IN VIBRIO CHOLERAE
    Role: Principal Investigator

Bibliographic
selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Chou S, Guo H, Zingl FG, Zhang S, Toska J, Xu B, Chen Y, Chen P, Waldor MK, Zhao W, Mekalanos JJ, Mou X. Synthetic peptides that form nanostructured micelles have potent antibiotic and antibiofilm activity against polymicrobial infections. Proc Natl Acad Sci U S A. 2023 Jan 24; 120(4):e2219679120. PMID: 36649429.
    Citations:    Fields:    
  2. Rubin DHF, Ma KC, Westervelt KA, Hullahalli K, Waldor MK, Grad YH. CanB is a metabolic mediator of antibiotic resistance in Neisseria gonorrhoeae. Nat Microbiol. 2023 Jan; 8(1):28-39. PMID: 36604513.
    Citations:    Fields:    Translation:HumansCells
  3. Rubin DHF, Zingl FG, Leitner DR, Ternier R, Compere V, Marseille S, Slater D, Harris JB, Chowdhury F, Qadri F, Boncy J, Ivers LC, Waldor MK. Reemergence of Cholera in Haiti. N Engl J Med. 2022 12 22; 387(25):2387-2389. PMID: 36449726.
    Citations:    Fields:    Translation:HumansPHPublic Health
  4. Sit B, Srisuknimit V, Bueno E, Zingl FG, Hullahalli K, Cava F, Waldor MK. Undecaprenyl phosphate translocases confer conditional microbial fitness. Nature. 2022 Nov 30. PMID: 36450355.
    Citations:    Fields:    
  5. Matute JD, Duan J, Flak MB, Griebel P, Tascon-Arcila JA, Doms S, Hanley T, Antanaviciute A, Gundrum J, Mark Welch JL, Sit B, Abtahi S, Fuhler GM, Grootjans J, Tran F, Stengel ST, White JR, Krupka N, Haller D, Clare S, Lawley TD, Kaser A, Simmons A, Glickman JN, Bry L, Rosenstiel P, Borisy G, Waldor MK, Baines JF, Turner JR, Blumberg RS. Intelectin-1 binds and alters the localization of the mucus barrier-modifying bacterium Akkermansia muciniphila. J Exp Med. 2023 Jan 02; 220(1). PMID: 36413219; PMCID: PMC9683900.
    Citations:    Fields:    Translation:HumansAnimalsCells
  6. Kimura S, Srisuknimit V, McCarty KL, Dedon PC, Kranzusch PJ, Waldor MK. Sequential action of a tRNA base editor in conversion of cytidine to pseudouridine. Nat Commun. 2022 Oct 11; 13(1):5994. PMID: 36220828; PMCID: PMC9553926.
    Citations:    Fields:    
  7. Sit B, Fakoya B, Waldor MK. Emerging Concepts in Cholera Vaccine Design. Annu Rev Microbiol. 2022 09 08; 76:681-702. PMID: 35759873.
    Citations:    Fields:    
  8. Fakoya B, Hullahalli K, Rubin DHF, Leitner DR, Chilengi R, Sack DA, Waldor MK. Nontoxigenic Vibrio cholerae Challenge Strains for Evaluating Vaccine Efficacy and Inferring Mechanisms of Protection. mBio. 2022 04 26; 13(2):e0053922. PMID: 35389261; PMCID: PMC9040834.
    Citations:    Fields:    Translation:HumansAnimalsCells
  9. Hounmanou YMG, Sit B, Fakoya B, Waldor MK, Dalsgaard A. Genomic and Phenotypic Insights for Toxigenic Clinical Vibrio cholerae O141. Emerg Infect Dis. 2022 03; 28(3):617-624. PMID: 35202520; PMCID: PMC8888207.
    Citations:    Fields:    Translation:HumansAnimalsCells
  10. Sit B, Fakoya B, Waldor MK. Animal models for dissecting Vibrio cholerae intestinal pathogenesis and immunity. Curr Opin Microbiol. 2022 02; 65:1-7. PMID: 34695646; PMCID: PMC8792189.
    Citations:    Fields:    Translation:AnimalsCells
  11. Zoued A, Zhang H, Zhang T, Giorgio RT, Kuehl CJ, Fakoya B, Sit B, Waldor MK. Proteomic analysis of the host-pathogen interface in experimental cholera. Nat Chem Biol. 2021 11; 17(11):1199-1208. PMID: 34675415.
    Citations: 1     Fields:    Translation:AnimalsCells
  12. Hullahalli K, Waldor MK. Pathogen clonal expansion underlies multiorgan dissemination and organ-specific outcomes during murine systemic infection. Elife. 2021 10 12; 10. PMID: 34636322; PMCID: PMC8545400.
    Citations: 1     Fields:    Translation:AnimalsCells
  13. Lazarus JE, Warr AR, Westervelt KA, Hooper DC, Waldor MK. A Genome-Scale Antibiotic Screen in Serratia marcescens Identifies YdgH as a Conserved Modifier of Cephalosporin and Detergent Susceptibility. Antimicrob Agents Chemother. 2021 11 17; 65(12):e0078621. PMID: 34491801; PMCID: PMC8597751.
    Citations:    Fields:    Translation:Cells
  14. Hullahalli K, Pritchard JR, Waldor MK. Refined Quantification of Infection Bottlenecks and Pathogen Dissemination with STAMPR. mSystems. 2021 Aug 31; 6(4):e0088721. PMID: 34402636; PMCID: PMC8407386.
    Citations: 3     
  15. Plaza N, Urrutia IM, Garcia K, Waldor MK, Blondel CJ. Identification of a Family of Vibrio Type III Secretion System Effectors That Contain a Conserved Serine/Threonine Kinase Domain. mSphere. 2021 08 25; 6(4):e0059921. PMID: 34346702; PMCID: PMC8386410.
    Citations: 1     Fields:    Translation:HumansCells
  16. Gensollen T, Lin X, Zhang T, Pyzik M, See P, Glickman JN, Ginhoux F, Waldor M, Salmi M, Rantakari P, Blumberg RS. Embryonic macrophages function during early life to determine invariant natural killer T cell levels at barrier surfaces. Nat Immunol. 2021 06; 22(6):699-710. PMID: 34040226; PMCID: PMC8171892.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  17. Elhenawy W, Hordienko S, Gould S, Oberc AM, Tsai CN, Hubbard TP, Waldor MK, Coombes BK. High-throughput fitness screening and transcriptomics identify a role for a type IV secretion system in the pathogenesis of Crohn's disease-associated Escherichia coli. Nat Commun. 2021 04 01; 12(1):2032. PMID: 33795670.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  18. Zhang T, Sasabe J, Hullahalli K, Sit B, Waldor MK. Increased Listeria monocytogenes Dissemination and Altered Population Dynamics in Muc2-Deficient Mice. Infect Immun. 2021 03 17; 89(4). PMID: 33431704.
    Citations: 2     Fields:    Translation:AnimalsCells
  19. Suzuki M, Sujino T, Chiba S, Harada Y, Goto M, Takahashi R, Mita M, Hamase K, Kanai T, Ito M, Waldor MK, Yasui M, Sasabe J. Host-microbe cross-talk governs amino acid chirality to regulate survival and differentiation of B cells. Sci Adv. 2021 03; 7(10). PMID: 33658193; PMCID: PMC7929512.
    Citations:    Fields:    Translation:AnimalsCells
  20. Baker-Austin C, Oliver JD, Alam M, Ali A, Waldor MK, Qadri F, Martinez-Urtaza J. Author Correction: Vibrio spp. infections. Nat Rev Dis Primers. 2021 Feb 19; 7(1):15. PMID: 33608543.
    Citations:    Fields:    
  21. Sit B, Fakoya B, Zhang T, Billings G, Waldor MK. Dissecting serotype-specific contributions to live oral cholera vaccine efficacy. Proc Natl Acad Sci U S A. 2021 02 16; 118(7). PMID: 33558237.
    Citations: 1     Fields:    Translation:AnimalsCells
  22. Del Peso Santos T, Alvarez L, Sit B, Irazoki O, Blake J, Warner BR, Warr AR, Bala A, Benes V, Waldor MK, Fredrick K, Cava F. BipA exerts temperature-dependent translational control of biofilm-associated colony morphology in Vibrio cholerae. Elife. 2021 02 12; 10. PMID: 33588990; PMCID: PMC7886329.
    Citations: 3     Fields:    Translation:Cells
  23. Warr AR, Kuehl CJ, Waldor MK. Shiga toxin remodels the intestinal epithelial transcriptional response to Enterohemorrhagic Escherichia coli. PLoS Pathog. 2021 02; 17(2):e1009290. PMID: 33529199.
    Citations: 4     Fields:    Translation:AnimalsCells
  24. Warr AR, Giorgio RT, Waldor MK. Genetic analysis of the role of the conserved inner membrane protein CvpA in EHEC resistance to deoxycholate. J Bacteriol. 2020 Dec 23. PMID: 33361192.
    Citations: 3     Fields:    
  25. Hu M, Zhang Y, Gu D, Chen X, Waldor MK, Zhou X. Nucleolar c-Myc recruitment by a Vibrio T3SS effector promotes host cell proliferation and bacterial virulence. EMBO J. 2021 01 15; 40(2):e105699. PMID: 33347626; PMCID: PMC7809790.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  26. Tian L, Wang XW, Wu AK, Fan Y, Friedman J, Dahlin A, Waldor MK, Weinstock GM, Weiss ST, Liu YY. Deciphering functional redundancy in the human microbiome. Nat Commun. 2020 12 04; 11(1):6217. PMID: 33277504.
    Citations: 27     Fields:    Translation:HumansCells
  27. Fakoya B, Sit B, Waldor MK. Transient Intestinal Colonization by a Live-Attenuated Oral Cholera Vaccine Induces Protective Immune Responses in Streptomycin-Treated Mice. J Bacteriol. 2020 11 19; 202(24). PMID: 32540930.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  28. Bueno E, Sit B, Waldor MK, Cava F. Genetic Dissection of the Fermentative and Respiratory Contributions Supporting Vibrio cholerae Hypoxic Growth. J Bacteriol. 2020 11 19; 202(24). PMID: 32631948.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  29. Charles RC, Kelly M, Tam JM, Akter A, Hossain M, Islam K, Biswas R, Kamruzzaman M, Chowdhury F, Khan AI, Leung DT, Weil A, LaRocque RC, Bhuiyan TR, Rahman A, Mayo-Smith LM, Becker RL, Vyas JM, Faherty CS, Nickerson KP, Giffen S, Ritter AS, Waldor MK, Xu P, Kovác P, Calderwood SB, Kauffman RC, Wrammert J, Qadri F, Harris JB, Ryan ET. Humans Surviving Cholera Develop Antibodies against Vibrio cholerae O-Specific Polysaccharide That Inhibit Pathogen Motility. mBio. 2020 11 17; 11(6). PMID: 33203761; PMCID: PMC7683404.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  30. Zhang H, Zoued A, Liu X, Sit B, Waldor MK. Type I interferon remodels lysosome function and modifies intestinal epithelial defense. Proc Natl Acad Sci U S A. 2020 11 24; 117(47):29862-29871. PMID: 33172989.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  31. Parker DJ, Lalanne JB, Kimura S, Johnson GE, Waldor MK, Li GW. Growth-Optimized Aminoacyl-tRNA Synthetase Levels Prevent Maximal tRNA Charging. Cell Syst. 2020 08 26; 11(2):121-130.e6. PMID: 32726597.
    Citations: 11     Fields:    Translation:Humans
  32. Kimura S, Srisuknimit V, Waldor MK. Probing the diversity and regulation of tRNA modifications. Curr Opin Microbiol. 2020 10; 57:41-48. PMID: 32663792; PMCID: PMC7722113.
    Citations: 4     Fields:    Translation:Cells
  33. Kimura S, Dedon PC, Waldor MK. Comparative tRNA sequencing and RNA mass spectrometry for surveying tRNA modifications. Nat Chem Biol. 2020 09; 16(9):964-972. PMID: 32514182; PMCID: PMC8172280.
    Citations: 14     Fields:    Translation:AnimalsCells
  34. Lipsitch M, Perlman S, Waldor MK. Testing COVID-19 therapies to prevent progression of mild disease. Lancet Infect Dis. 2020 12; 20(12):1367. PMID: 32618282.
    Citations: 4     Fields:    Translation:HumansCellsPHPublic Health
  35. Hernández SB, Dörr T, Waldor MK, Cava F. Modulation of Peptidoglycan Synthesis by Recycled Cell Wall Tetrapeptides. Cell Rep. 2020 04 28; 31(4):107578. PMID: 32348759.
    Citations: 11     Fields:    Translation:Cells
  36. Kuehl CJ, D'Gama JD, Warr AR, Waldor MK. An Oral Inoculation Infant Rabbit Model for Shigella Infection. mBio. 2020 01 21; 11(1). PMID: 31964739.
    Citations: 2     Fields:    Translation:AnimalsCells
  37. Louie A, Zhang T, Becattini S, Waldor MK, Portnoy DA. A Multiorgan Trafficking Circuit Provides Purifying Selection of Listeria monocytogenes Virulence Genes. mBio. 2019 12 17; 10(6). PMID: 31848289.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  38. D'Gama JD, Ma Z, Zhang H, Liu X, Fan H, Morris ERA, Cohen ND, Cywes-Bentley C, Pier GB, Waldor MK. A Conserved Streptococcal Virulence Regulator Controls the Expression of a Distinct Class of M-Like Proteins. mBio. 2019 10 22; 10(5). PMID: 31641092.
    Citations: 3     Fields:    Translation:AnimalsCells
  39. Wei L, Qiao H, Sit B, Yin K, Yang G, Ma R, Ma J, Yang C, Yao J, Ma Y, Xiao J, Liu X, Zhang Y, Waldor MK, Wang Q. A Bacterial Pathogen Senses Host Mannose to Coordinate Virulence. iScience. 2019 Oct 25; 20:310-323. PMID: 31605945.
    Citations: 7     
  40. Warr AR, Hubbard TP, Munera D, Blondel CJ, Abel Zur Wiesch P, Abel S, Wang X, Davis BM, Waldor MK. Transposon-insertion sequencing screens unveil requirements for EHEC growth and intestinal colonization. PLoS Pathog. 2019 08; 15(8):e1007652. PMID: 31404118.
    Citations: 18     Fields:    Translation:AnimalsCells
  41. Lazarus JE, Warr AR, Kuehl CJ, Giorgio RT, Davis BM, Waldor MK. A New Suite of Allelic-Exchange Vectors for the Scarless Modification of Proteobacterial Genomes. Appl Environ Microbiol. 2019 08 15; 85(16). PMID: 31201277.
    Citations: 9     Fields:    Translation:Cells
  42. Fleurie A, Zoued A, Alvarez L, Hines KM, Cava F, Xu L, Davis BM, Waldor MK. A Vibrio cholerae BolA-Like Protein Is Required for Proper Cell Shape and Cell Envelope Integrity. mBio. 2019 07 09; 10(4). PMID: 31289173; PMCID: PMC6747721.
    Citations: 10     Fields:    Translation:AnimalsCells
  43. D'Gama JD, Waldor MK. An 'i' for ingenuity. Nat Microbiol. 2019 07; 4(7):1071-1072. PMID: 31222173.
    Citations:    Fields:    Translation:Cells
  44. Sit B, Zhang T, Fakoya B, Akter A, Biswas R, Ryan ET, Waldor MK. Oral immunization with a probiotic cholera vaccine induces broad protective immunity against Vibrio cholerae colonization and disease in mice. PLoS Negl Trop Dis. 2019 05; 13(5):e0007417. PMID: 31150386.
    Citations: 9     Fields:    Translation:HumansAnimalsCellsPHPublic Health
  45. Ma Z, Peng J, Yu D, Park JS, Lin H, Xu B, Lu C, Fan H, Waldor MK. A streptococcal Fic domain-containing protein disrupts blood-brain barrier integrity by activating moesin in endothelial cells. PLoS Pathog. 2019 05; 15(5):e1007737. PMID: 31071198; PMCID: PMC6529018.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  46. Hubbard TP, D'Gama JD, Billings G, Davis BM, Waldor MK. Unsupervised Learning Approach for Comparing Multiple Transposon Insertion Sequencing Studies. mSphere. 2019 02 20; 4(1). PMID: 30787116; PMCID: PMC6382967.
    Citations: 7     Fields:    Translation:Cells
  47. Kimura S, Waldor MK. The RNA degradosome promotes tRNA quality control through clearance of hypomodified tRNA. Proc Natl Acad Sci U S A. 2019 01 22; 116(4):1394-1403. PMID: 30622183; PMCID: PMC6347707.
    Citations: 30     Fields:    Translation:Cells
  48. Carda-Diéguez M, Silva-Hernández FX, Hubbard TP, Chao MC, Waldor MK, Amaro C. Comprehensive identification of Vibrio vulnificus genes required for growth in human serum. Virulence. 2018 12 31; 9(1):981-993. PMID: 29697309.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  49. Park JS, Helble JD, Lazarus JE, Yang G, Blondel CJ, Doench JG, Starnbach MN, Waldor MK. A FACS-Based Genome-wide CRISPR Screen Reveals a Requirement for COPI in Chlamydia trachomatis Invasion. iScience. 2019 Jan 25; 11:71-84. PMID: 30590252; PMCID: PMC6308251.
    Citations: 5     
  50. Bueno E, Sit B, Waldor MK, Cava F. Anaerobic nitrate reduction divergently governs population expansion of the enteropathogen Vibrio cholerae. Nat Microbiol. 2018 12; 3(12):1346-1353. PMID: 30275512; PMCID: PMC6443258.
    Citations: 15     Fields:    Translation:AnimalsCells
  51. Weaver AI, Murphy SG, Umans BD, Tallavajhala S, Onyekwere I, Wittels S, Shin JH, VanNieuwenhze M, Waldor MK, Dörr T. Genetic Determinants of Penicillin Tolerance in Vibrio cholerae. Antimicrob Agents Chemother. 2018 10; 62(10). PMID: 30061291; PMCID: PMC6153846.
    Citations: 17     Fields:    Translation:Cells
  52. Yin K, Guan Y, Ma R, Wei L, Liu B, Liu X, Zhou X, Ma Y, Zhang Y, Waldor MK, Wang Q. Critical role for a promoter discriminator in RpoS control of virulence in Edwardsiella piscicida. PLoS Pathog. 2018 08; 14(8):e1007272. PMID: 30169545; PMCID: PMC6136808.
    Citations: 12     Fields:    Translation:AnimalsCells
  53. Baker-Austin C, Oliver JD, Alam M, Ali A, Waldor MK, Qadri F, Martinez-Urtaza J. Vibrio spp. infections. Nat Rev Dis Primers. 2018 07 12; 4(1):8. PMID: 30002421.
    Citations: 120     Fields:    Translation:HumansCells
  54. Pacheco AR, Lazarus JE, Sit B, Schmieder S, Lencer WI, Blondel CJ, Doench JG, Davis BM, Waldor MK. CRISPR Screen Reveals that EHEC's T3SS and Shiga Toxin Rely on Shared Host Factors for Infection. mBio. 2018 06 19; 9(3). PMID: 29921669; PMCID: PMC6016243.
    Citations: 25     Fields:    Translation:HumansCells