Harvard Catalyst Profiles

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Matthew K Waldor, M.D., Ph.D.

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Other Positions
Title
Institution
Department

Mentoring
current student opportunities
Available: 10/20/18, Expires: 09/30/22

Our lab studies the biology of Vibrio cholerae, the agent of cholera, and E. coli O157, a common cause of diarrheal disease in the USA. We are using a wide range of techniques to understand how these pathogens cause disease. We study both basic questions, such as how bacterial chromosomes replicate and segregate, and more applied issues such as development of new antibiotics and vaccines for diarrheal diseases.

Available: 09/01/19, Expires: 08/31/22

The student will conduct a genome-wide screen to identify pathogen or host genes that contribute to pathogenesis of diseases caused by enteric pathogens. The student will be engaged in all steps of the project from creation of mutant libraries to analyses of the big data that screens generate. Some experience in molecular biology is preferable.


Research
research activities and funding
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
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  1. T32AI007329 (HU, LINDEN T) Dec 1, 2016 - Jun 30, 2019
    NIH/NIAID
    Infectious Disease Training-Pathogenesis/Host Response
    Role: Co-Principal Investigator
  2. R21AI067827 (WALDOR, MATTHEW K) Feb 1, 2006 - Jan 31, 2009
    NIH/NIAID
    Intestinal colonization of Enterohemorrhagic E. coil
    Role: Principal Investigator
  3. R21AI059698 (WALDOR, MATTHEW K) Apr 1, 2004 - Mar 31, 2007
    NIH/NIAID
    Role of Hfq in Vibrio cholerae virulence
    Role: Principal Investigator
  4. R01AI042347 (WALDOR, MATTHEW K) Jan 1, 1998 - May 31, 2022
    NIH/NIAID
    Vibrio cholerae intestinal colonization and vaccine development
    Role: Principal Investigator
  5. R37AI042347 (WALDOR, MATTHEW K) Jan 1, 1998 - Dec 31, 2017
    NIH/NIAID
    Molecular Biology and Virulence of CTX Phage
    Role: Principal Investigator

Bibliographic
selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Parker DJ, Lalanne JB, Kimura S, Johnson GE, Waldor MK, Li GW. Growth-Optimized Aminoacyl-tRNA Synthetase Levels Prevent Maximal tRNA Charging. Cell Syst. 2020 Aug 26; 11(2):121-130.e6. PMID: 32726597.
    Citations:    Fields:    
  2. Kimura S, Srisuknimit V, Waldor MK. Probing the diversity and regulation of tRNA modifications. Curr Opin Microbiol. 2020 Jul 11; 57:41-48. PMID: 32663792.
    Citations:    Fields:    
  3. Bueno E, Sit B, Waldor MK, Cava F. Genetic dissection of the fermentative and respiratory contributions supporting Vibrio cholerae hypoxic growth. J Bacteriol. 2020 Jul 06. PMID: 32631948.
    Citations: 1     Fields:    
  4. Fakoya B, Sit B, Waldor MK. Transient intestinal colonization by a live-attenuated oral cholera vaccine induces protective immune responses in streptomycin-treated mice. J Bacteriol. 2020 Jun 15. PMID: 32540930.
    Citations:    Fields:    
  5. Kimura S, Dedon PC, Waldor MK. Comparative tRNA sequencing and RNA mass spectrometry for surveying tRNA modifications. Nat Chem Biol. 2020 09; 16(9):964-972. PMID: 32514182.
    Citations: 1     Fields:    
  6. Lipsitch M, Perlman S, Waldor MK. Testing COVID-19 therapies to prevent progression of mild disease. Lancet Infect Dis. 2020 May 06. PMID: 32618282.
    Citations:    Fields:    
  7. Hernández SB, Dörr T, Waldor MK, Cava F. Modulation of Peptidoglycan Synthesis by Recycled Cell Wall Tetrapeptides. Cell Rep. 2020 04 28; 31(4):107578. PMID: 32348759.
    Citations:    Fields:    
  8. Kuehl CJ, D'Gama JD, Warr AR, Waldor MK. An Oral Inoculation Infant Rabbit Model for Shigella Infection. mBio. 2020 01 21; 11(1). PMID: 31964739.
    Citations:    Fields:    Translation:AnimalsCells
  9. Louie A, Zhang T, Becattini S, Waldor MK, Portnoy DA. A Multiorgan Trafficking Circuit Provides Purifying Selection of Listeria monocytogenes Virulence Genes. mBio. 2019 12 17; 10(6). PMID: 31848289.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  10. D'Gama JD, Ma Z, Zhang H, Liu X, Fan H, Morris ERA, Cohen ND, Cywes-Bentley C, Pier GB, Waldor MK. A Conserved Streptococcal Virulence Regulator Controls the Expression of a Distinct Class of M-Like Proteins. mBio. 2019 10 22; 10(5). PMID: 31641092.
    Citations: 1     Fields:    Translation:AnimalsCells
  11. Wei L, Qiao H, Sit B, Yin K, Yang G, Ma R, Ma J, Yang C, Yao J, Ma Y, Xiao J, Liu X, Zhang Y, Waldor MK, Wang Q. A Bacterial Pathogen Senses Host Mannose to Coordinate Virulence. iScience. 2019 Oct 25; 20:310-323. PMID: 31605945.
    Citations: 2     
  12. Warr AR, Hubbard TP, Munera D, Blondel CJ, Abel Zur Wiesch P, Abel S, Wang X, Davis BM, Waldor MK. Transposon-insertion sequencing screens unveil requirements for EHEC growth and intestinal colonization. PLoS Pathog. 2019 08; 15(8):e1007652. PMID: 31404118.
    Citations: 5     Fields:    Translation:AnimalsCells
  13. Lazarus JE, Warr AR, Kuehl CJ, Giorgio RT, Davis BM, Waldor MK. A New Suite of Allelic-Exchange Vectors for the Scarless Modification of Proteobacterial Genomes. Appl Environ Microbiol. 2019 08 15; 85(16). PMID: 31201277.
    Citations: 3     Fields:    Translation:Cells
  14. Fleurie A, Zoued A, Alvarez L, Hines KM, Cava F, Xu L, Davis BM, Waldor MK. A Vibrio cholerae BolA-Like Protein Is Required for Proper Cell Shape and Cell Envelope Integrity. mBio. 2019 07 09; 10(4). PMID: 31289173.
    Citations: 1     Fields:    Translation:AnimalsCells
  15. D'Gama JD, Waldor MK. An 'i' for ingenuity. Nat Microbiol. 2019 07; 4(7):1071-1072. PMID: 31222173.
    Citations:    Fields:    Translation:Cells
  16. Sit B, Zhang T, Fakoya B, Akter A, Biswas R, Ryan ET, Waldor MK. Oral immunization with a probiotic cholera vaccine induces broad protective immunity against Vibrio cholerae colonization and disease in mice. PLoS Negl Trop Dis. 2019 05; 13(5):e0007417. PMID: 31150386.
    Citations: 1     Fields:    Translation:HumansAnimalsCellsPHPublic Health
  17. Ma Z, Peng J, Yu D, Park JS, Lin H, Xu B, Lu C, Fan H, Waldor MK. A streptococcal Fic domain-containing protein disrupts blood-brain barrier integrity by activating moesin in endothelial cells. PLoS Pathog. 2019 05; 15(5):e1007737. PMID: 31071198.
    Citations:    Fields:    Translation:HumansAnimalsCells
  18. Hubbard TP, D'Gama JD, Billings G, Davis BM, Waldor MK. Unsupervised Learning Approach for Comparing Multiple Transposon Insertion Sequencing Studies. mSphere. 2019 02 20; 4(1). PMID: 30787116.
    Citations: 5     Fields:    Translation:Cells
  19. Kimura S, Waldor MK. The RNA degradosome promotes tRNA quality control through clearance of hypomodified tRNA. Proc Natl Acad Sci U S A. 2019 01 22; 116(4):1394-1403. PMID: 30622183.
    Citations: 9     Fields:    Translation:Cells
  20. Carda-Diéguez M, Silva-Hernández FX, Hubbard TP, Chao MC, Waldor MK, Amaro C. Comprehensive identification of Vibrio vulnificus genes required for growth in human serum. Virulence. 2018 12 31; 9(1):981-993. PMID: 29697309.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  21. Park JS, Helble JD, Lazarus JE, Yang G, Blondel CJ, Doench JG, Starnbach MN, Waldor MK. A FACS-Based Genome-wide CRISPR Screen Reveals a Requirement for COPI in Chlamydia trachomatis Invasion. iScience. 2019 Jan 25; 11:71-84. PMID: 30590252.
    Citations: 1     
  22. Bueno E, Sit B, Waldor MK, Cava F. Anaerobic nitrate reduction divergently governs population expansion of the enteropathogen Vibrio cholerae. Nat Microbiol. 2018 12; 3(12):1346-1353. PMID: 30275512.
    Citations: 5     Fields:    Translation:AnimalsCells
  23. Weaver AI, Murphy SG, Umans BD, Tallavajhala S, Onyekwere I, Wittels S, Shin JH, VanNieuwenhze M, Waldor MK, Dörr T. Genetic Determinants of Penicillin Tolerance in Vibrio cholerae. Antimicrob Agents Chemother. 2018 10; 62(10). PMID: 30061291.
    Citations: 6     Fields:    Translation:Cells
  24. Yin K, Guan Y, Ma R, Wei L, Liu B, Liu X, Zhou X, Ma Y, Zhang Y, Waldor MK, Wang Q. Critical role for a promoter discriminator in RpoS control of virulence in Edwardsiella piscicida. PLoS Pathog. 2018 08; 14(8):e1007272. PMID: 30169545.
    Citations:    Fields:    Translation:AnimalsCells
  25. Baker-Austin C, Oliver JD, Alam M, Ali A, Waldor MK, Qadri F, Martinez-Urtaza J. Vibrio spp. infections. Nat Rev Dis Primers. 2018 07 12; 4(1):8. PMID: 30002421.
    Citations: 24     Fields:    Translation:HumansCells
  26. Pacheco AR, Lazarus JE, Sit B, Schmieder S, Lencer WI, Blondel CJ, Doench JG, Davis BM, Waldor MK. CRISPR Screen Reveals that EHEC's T3SS and Shiga Toxin Rely on Shared Host Factors for Infection. mBio. 2018 06 19; 9(3). PMID: 29921669.
    Citations: 6     Fields:    Translation:HumansCells
  27. Hubbard TP, Billings G, Dörr T, Sit B, Warr AR, Kuehl CJ, Kim M, Delgado F, Mekalanos JJ, Lewnard JA, Waldor MK. A live vaccine rapidly protects against cholera in an infant rabbit model. Sci Transl Med. 2018 06 13; 10(445). PMID: 29899024.
    Citations: 6     Fields:    Translation:Animals
  28. Giles M, Cawthraw SA, AbuOun M, Thomas CM, Munera D, Waldor MK, La Ragione RM, Ritchie JM. Host-specific differences in the contribution of an ESBL IncI1 plasmid to intestinal colonization by Escherichia coli O104:H4. J Antimicrob Chemother. 2018 06 01; 73(6):1579-1585. PMID: 29506073.
    Citations:    Fields:    Translation:AnimalsCells
  29. Cameron EA, Gruber CC, Ritchie JM, Waldor MK, Sperandio V. The QseG Lipoprotein Impacts the Virulence of Enterohemorrhagic Escherichia coli and Citrobacter rodentium and Regulates Flagellar Phase Variation in Salmonella enterica Serovar Typhimurium. Infect Immun. 2018 04; 86(4). PMID: 29358334.
    Citations: 1     Fields:    Translation:AnimalsCells
  30. Yang Z, Zhou X, Ma Y, Zhou M, Waldor MK, Zhang Y, Wang Q. Serine/threonine kinase PpkA coordinates the interplay between T6SS2 activation and quorum sensing in the marine pathogen Vibrio alginolyticus. Environ Microbiol. 2018 02; 20(2):903-919. PMID: 29314504.
    Citations: 4     Fields:    Translation:Cells
  31. Xiao Y, Angulo MT, Friedman J, Waldor MK, Weiss ST, Liu YY. Mapping the ecological networks of microbial communities. Nat Commun. 2017 12 11; 8(1):2042. PMID: 29229902.
    Citations: 9     Fields:    Translation:HumansAnimalsCellsPHPublic Health
  32. Alvarado A, Kjær A, Yang W, Mann P, Briegel A, Waldor MK, Ringgaard S. Coupling chemosensory array formation and localization. Elife. 2017 10 23; 6. PMID: 29058677.
    Citations: 3     Fields:    Translation:Cells
  33. Yang G, Billings G, Hubbard TP, Park JS, Yin Leung K, Liu Q, Davis BM, Zhang Y, Wang Q, Waldor MK. Time-Resolved Transposon Insertion Sequencing Reveals Genome-Wide Fitness Dynamics during Infection. mBio. 2017 10 03; 8(5). PMID: 28974620.
    Citations: 5     Fields:    Translation:AnimalsCells
  34. Zhang T, Abel S, Abel Zur Wiesch P, Sasabe J, Davis BM, Higgins DE, Waldor MK. Deciphering the landscape of host barriers to Listeria monocytogenes infection. Proc Natl Acad Sci U S A. 2017 06 13; 114(24):6334-6339. PMID: 28559314.
    Citations: 12     Fields:    Translation:AnimalsCells
  35. Orlova N, Gerding M, Ivashkiv O, Olinares PDB, Chait BT, Waldor MK, Jeruzalmi D. The replication initiator of the cholera pathogen's second chromosome shows structural similarity to plasmid initiators. Nucleic Acids Res. 2017 04 20; 45(7):3724-3737. PMID: 28031373.
    Citations: 9     Fields:    Translation:Cells
  36. Kimura S, Hubbard TP, Davis BM, Waldor MK. The Nucleoid Binding Protein H-NS Biases Genome-Wide Transposon Insertion Landscapes. mBio. 2016 08 30; 7(4). PMID: 27578758.
    Citations: 12     Fields:    Translation:Cells
  37. Sasabe J, Miyoshi Y, Rakoff-Nahoum S, Zhang T, Mita M, Davis BM, Hamase K, Waldor MK. Interplay between microbial d-amino acids and host d-amino acid oxidase modifies murine mucosal defence and gut microbiota. Nat Microbiol. 2016 07 25; 1(10):16125. PMID: 27670111.
    Citations: 17     Fields:    Translation:HumansAnimalsCells
  38. Dörr T, Delgado F, Umans BD, Gerding MA, Davis BM, Waldor MK. A Transposon Screen Identifies Genetic Determinants of Vibrio cholerae Resistance to High-Molecular-Weight Antibiotics. Antimicrob Agents Chemother. 2016 08; 60(8):4757-63. PMID: 27216069.
    Citations: 7     Fields:    Translation:Cells
  39. Blondel CJ, Park JS, Hubbard TP, Pacheco AR, Kuehl CJ, Walsh MJ, Davis BM, Gewurz BE, Doench JG, Waldor MK. CRISPR/Cas9 Screens Reveal Requirements for Host Cell Sulfation and Fucosylation in Bacterial Type III Secretion System-Mediated Cytotoxicity. . 2016 Aug 10; 20(2):226-37. PMID: 27453484.
    Citations: 17     Translation:HumansCells
  40. Moreira CG, Russell R, Mishra AA, Narayanan S, Ritchie JM, Waldor MK, Curtis MM, Winter SE, Weinshenker D, Sperandio V. Bacterial Adrenergic Sensors Regulate Virulence of Enteric Pathogens in the Gut. mBio. 2016 06 07; 7(3). PMID: 27273829.
    Citations: 22     Fields:    Translation:AnimalsCells
  41. Rajpurohit YS, Bihani SC, Waldor MK, Misra HS. Phosphorylation of Deinococcus radiodurans RecA Regulates Its Activity and May Contribute to Radioresistance. J Biol Chem. 2016 08 05; 291(32):16672-85. PMID: 27255712.
    Citations: 6     Fields:    Translation:Cells
  42. Hatzios SK, Abel S, Martell J, Hubbard T, Sasabe J, Munera D, Clark L, Bachovchin DA, Qadri F, Ryan ET, Davis BM, Weerapana E, Waldor MK. Erratum: Chemoproteomic profiling of host and pathogen enzymes active in cholera. Nat Chem Biol. 2016 05 18; 12(6):466. PMID: 27191648.
    Citations:    Fields:    
  43. Hubbard TP, Chao MC, Abel S, Blondel CJ, Abel Zur Wiesch P, Zhou X, Davis BM, Waldor MK. Genetic analysis of Vibrio parahaemolyticus intestinal colonization. Proc Natl Acad Sci U S A. 2016 May 31; 113(22):6283-8. PMID: 27185914.
    Citations: 20     Fields:    Translation:HumansAnimalsCells
  44. Hatzios SK, Abel S, Martell J, Hubbard T, Sasabe J, Munera D, Clark L, Bachovchin DA, Qadri F, Ryan ET, Davis BM, Weerapana E, Waldor MK. Chemoproteomic profiling of host and pathogen enzymes active in cholera. Nat Chem Biol. 2016 Apr; 12(4):268-274. PMID: 26900865.
    Citations: 15     Fields:    Translation:HumansAnimalsCells
  45. Chao MC, Abel S, Davis BM, Waldor MK. The design and analysis of transposon insertion sequencing experiments. Nat Rev Microbiol. 2016 02; 14(2):119-28. PMID: 26775926.
    Citations: 35     Fields:    Translation:Cells
  46. Dörr T, Alvarez L, Delgado F, Davis BM, Cava F, Waldor MK. A cell wall damage response mediated by a sensor kinase/response regulator pair enables beta-lactam tolerance. Proc Natl Acad Sci U S A. 2016 Jan 12; 113(2):404-9. PMID: 26712007.
    Citations: 15     Fields:    Translation:Cells
  47. Chao MC, Zhu S, Kimura S, Davis BM, Schadt EE, Fang G, Waldor MK. Correction: A Cytosine Methytransferase Modulates the Cell Envelope Stress Response in the Cholera Pathogen. PLoS Genet. 2015 Dec; 11(12):e1005739. PMID: 26657207.
    Citations:    Fields:    
  48. Chao MC, Zhu S, Kimura S, Davis BM, Schadt EE, Fang G, Waldor MK. A Cytosine Methyltransferase Modulates the Cell Envelope Stress Response in the Cholera Pathogen [corrected]. PLoS Genet. 2015 Nov; 11(11):e1005666. PMID: 26588462.
    Citations: 8     Fields:    Translation:Cells
  49. Kieser KJ, Baranowski C, Chao MC, Long JE, Sassetti CM, Waldor MK, Sacchettini JC, Ioerger TR, Rubin EJ. Peptidoglycan synthesis in Mycobacterium tuberculosis is organized into networks with varying drug susceptibility. Proc Natl Acad Sci U S A. 2015 Oct 20; 112(42):13087-92. PMID: 26438867.
    Citations: 24     Fields:    Translation:Cells
  50. Abel S, Waldor MK. Infant Rabbit Model for Diarrheal Diseases. Curr Protoc Microbiol. 2015 Aug 03; 38:6A.6.1-15. PMID: 26237109.
    Citations: 6     Fields:    Translation:Animals
  51. Gerding MA, Chao MC, Davis BM, Waldor MK. Molecular Dissection of the Essential Features of the Origin of Replication of the Second Vibrio cholerae Chromosome. mBio. 2015 Jul 28; 6(4):e00973. PMID: 26220967.
    Citations: 11     Fields:    Translation:Cells
  52. Osorio CR, Rivas AJ, Balado M, Fuentes-Monteverde JC, Rodríguez J, Jiménez C, Lemos ML, Waldor MK. A Transmissible Plasmid-Borne Pathogenicity Island Confers Piscibactin Biosynthesis in the Fish Pathogen Photobacterium damselae subsp. piscicida. Appl Environ Microbiol. 2015 Sep 01; 81(17):5867-79. PMID: 26092457.
    Citations: 10     Fields:    Translation:AnimalsCells
  53. Beaulaurier J, Zhang XS, Zhu S, Sebra R, Rosenbluh C, Deikus G, Shen N, Munera D, Waldor MK, Chess A, Blaser MJ, Schadt EE, Fang G. Single molecule-level detection and long read-based phasing of epigenetic variations in bacterial methylomes. Nat Commun. 2015 Jun 15; 6:7438. PMID: 26074426.
    Citations: 16     Fields:    Translation:Cells
  54. Abel S, Abel zur Wiesch P, Davis BM, Waldor MK. Analysis of Bottlenecks in Experimental Models of Infection. PLoS Pathog. 2015 Jun; 11(6):e1004823. PMID: 26066486.
    Citations: 30     Fields:    Translation:HumansAnimals
  55. Wang Q, Millet YA, Chao MC, Sasabe J, Davis BM, Waldor MK. A Genome-Wide Screen Reveals that the Vibrio cholerae Phosphoenolpyruvate Phosphotransferase System Modulates Virulence Gene Expression. Infect Immun. 2015 Sep; 83(9):3381-95. PMID: 26056384.
    Citations: 7     Fields:    Translation:AnimalsCells
  56. Ringgaard S, Hubbard T, Mandlik A, Davis BM, Waldor MK. RpoS and quorum sensing control expression and polar localization of Vibrio cholerae chemotaxis cluster III proteins in vitro and in vivo. Mol Microbiol. 2015 Aug; 97(4):660-75. PMID: 25989366.
    Citations: 11     Fields:    Translation:AnimalsCells
  57. Abel Zur Wiesch P, Abel S, Gkotzis S, Ocampo P, Engelstädter J, Hinkley T, Magnus C, Waldor MK, Udekwu K, Cohen T. Classic reaction kinetics can explain complex patterns of antibiotic action. Sci Transl Med. 2015 May 13; 7(287):287ra73. PMID: 25972005.
    Citations: 17     Fields:    Translation:Cells
  58. Dörr T, Davis BM, Waldor MK. Endopeptidase-mediated beta lactam tolerance. PLoS Pathog. 2015 Apr; 11(4):e1004850. PMID: 25884840.
    Citations: 14     Fields:    Translation:Cells
  59. Möll A, Dörr T, Alvarez L, Davis BM, Cava F, Waldor MK. A D, D-carboxypeptidase is required for Vibrio cholerae halotolerance. Environ Microbiol. 2015 Feb; 17(2):527-40. PMID: 25631756.
    Citations: 9     Fields:    Translation:AnimalsCells
  60. Waldor MK, Tyson G, Borenstein E, Ochman H, Moeller A, Finlay BB, Kong HH, Gordon JI, Nelson KE, Dabbagh K, Smith H. Where next for microbiome research? PLoS Biol. 2015 Jan; 13(1):e1002050. PMID: 25602283.
    Citations: 40     Fields:    Translation:Humans
  61. Abel S, Abel zur Wiesch P, Chang HH, Davis BM, Lipsitch M, Waldor MK. Sequence tag-based analysis of microbial population dynamics. Nat Methods. 2015 Mar; 12(3):223-6, 3 p following 226. PMID: 25599549.
    Citations: 21     Fields:    Translation:AnimalsCells
  62. Yamaichi Y, Chao MC, Sasabe J, Clark L, Davis BM, Yamamoto N, Mori H, Kurokawa K, Waldor MK. High-resolution genetic analysis of the requirements for horizontal transmission of the ESBL plasmid from Escherichia coli O104:H4. Nucleic Acids Res. 2015 Jan; 43(1):348-60. PMID: 25477379.
    Citations: 12     Fields:    Translation:Cells
  63. Pritchard JR, Chao MC, Abel S, Davis BM, Baranowski C, Zhang YJ, Rubin EJ, Waldor MK. ARTIST: high-resolution genome-wide assessment of fitness using transposon-insertion sequencing. PLoS Genet. 2014 Nov; 10(11):e1004782. PMID: 25375795.
    Citations: 52     Fields:    Translation:Cells
  64. Millet YA, Alvarez D, Ringgaard S, von Andrian UH, Davis BM, Waldor MK. Insights into Vibrio cholerae intestinal colonization from monitoring fluorescently labeled bacteria. PLoS Pathog. 2014 Oct; 10(10):e1004405. PMID: 25275396.
    Citations: 50     Fields:    Translation:HumansAnimalsCells
  65. Livny J, Zhou X, Mandlik A, Hubbard T, Davis BM, Waldor MK. Comparative RNA-Seq based dissection of the regulatory networks and environmental stimuli underlying Vibrio parahaemolyticus gene expression during infection. Nucleic Acids Res. 2014 Oct 29; 42(19):12212-23. PMID: 25262354.
    Citations: 15     Fields:    Translation:AnimalsCells
  66. Möll A, Dörr T, Alvarez L, Chao MC, Davis BM, Cava F, Waldor MK. Cell separation in Vibrio cholerae is mediated by a single amidase whose action is modulated by two nonredundant activators. J Bacteriol. 2014 Nov; 196(22):3937-48. PMID: 25182499.
    Citations: 22     Fields:    Translation:AnimalsCells
  67. Zhou X, Massol RH, Nakamura F, Chen X, Gewurz BE, Davis BM, Lencer WI, Waldor MK. Remodeling of the intestinal brush border underlies adhesion and virulence of an enteric pathogen. mBio. 2014 Aug 19; 5(4). PMID: 25139905.
    Citations: 9     Fields:    Translation:AnimalsCells
  68. Dörr T, Lam H, Alvarez L, Cava F, Davis BM, Waldor MK. A novel peptidoglycan binding protein crucial for PBP1A-mediated cell wall biogenesis in Vibrio cholerae. PLoS Genet. 2014 Jun; 10(6):e1004433. PMID: 24945690.
    Citations: 17     Fields:    Translation:Cells
  69. Taylor DL, Bina XR, Slamti L, Waldor MK, Bina JE. Reciprocal regulation of resistance-nodulation-division efflux systems and the Cpx two-component system in Vibrio cholerae. Infect Immun. 2014 Jul; 82(7):2980-91. PMID: 24799626.
    Citations: 13     Fields:    Translation:Cells
  70. Lu X, Skurnik D, Pozzi C, Roux D, Cywes-Bentley C, Ritchie JM, Munera D, Gening ML, Tsvetkov YE, Nifantiev NE, Waldor MK, Pier GB. A Poly-N-acetylglucosamine-Shiga toxin broad-spectrum conjugate vaccine for Shiga toxin-producing Escherichia coli. mBio. 2014 Mar 25; 5(2):e00974-14. PMID: 24667709.
    Citations: 5     Fields:    Translation:AnimalsCells
  71. Dörr T, Möll A, Chao MC, Cava F, Lam H, Davis BM, Waldor MK. Differential requirement for PBP1a and PBP1b in in vivo and in vitro fitness of Vibrio cholerae. Infect Immun. 2014 May; 82(5):2115-24. PMID: 24614657.
    Citations: 17     Fields:    Translation:AnimalsCells
  72. Kota S, Charaka VK, Ringgaard S, Waldor MK, Misra HS. PprA contributes to Deinococcus radiodurans resistance to nalidixic acid, genome maintenance after DNA damage and interacts with deinococcal topoisomerases. PLoS One. 2014; 9(1):e85288. PMID: 24454836.
    Citations: 9     Fields:    Translation:Cells
  73. Okada R, Zhou X, Hiyoshi H, Matsuda S, Chen X, Akeda Y, Kashimoto T, Davis BM, Iida T, Waldor MK, Kodama T. The Vibrio parahaemolyticus effector VopC mediates Cdc42-dependent invasion of cultured cells but is not required for pathogenicity in an animal model of infection. Cell Microbiol. 2014 Jun; 16(6):938-47. PMID: 24345190.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  74. Munera D, Ritchie JM, Hatzios SK, Bronson R, Fang G, Schadt EE, Davis BM, Waldor MK. Autotransporters but not pAA are critical for rabbit colonization by Shiga toxin-producing Escherichia coli O104:H4. Nat Commun. 2014; 5:3080. PMID: 24445323.
    Citations: 21     Fields:    Translation:AnimalsCells
  75. Ringgaard S, Zepeda-Rivera M, Wu X, Schirner K, Davis BM, Waldor MK. ParP prevents dissociation of CheA from chemotactic signaling arrays and tethers them to a polar anchor. Proc Natl Acad Sci U S A. 2014 Jan 14; 111(2):E255-64. PMID: 24379357.
    Citations: 15     Fields:    Translation:Cells
  76. Espaillat A, Carrasco-López C, Bernardo-García N, Pietrosemoli N, Otero LH, Álvarez L, de Pedro MA, Pazos F, Davis BM, Waldor MK, Hermoso JA, Cava F. Structural basis for the broad specificity of a new family of amino-acid racemases. Acta Crystallogr D Biol Crystallogr. 2014 Jan; 70(Pt 1):79-90. PMID: 24419381.
    Citations: 9     Fields:    Translation:Cells
  77. Fu Y, Waldor MK, Mekalanos JJ. Tn-Seq analysis of Vibrio cholerae intestinal colonization reveals a role for T6SS-mediated antibacterial activity in the host. . 2013 Dec 11; 14(6):652-63. PMID: 24331463.
    Citations: 92     Translation:AnimalsCells
  78. Grad YH, Waldor MK. Deciphering the origins and tracking the evolution of cholera epidemics with whole-genome-based molecular epidemiology. mBio. 2013 Sep 10; 4(5):e00670-13. PMID: 24023387.
    Citations: 6     Fields:    Translation:HumansCellsPHPublic Health
  79. Davis BM, Waldor MK. Establishing polar identity in gram-negative rods. Curr Opin Microbiol. 2013 Dec; 16(6):752-9. PMID: 24029491.
    Citations: 9     Fields:    Translation:Cells
  80. Chao MC, Pritchard JR, Zhang YJ, Rubin EJ, Livny J, Davis BM, Waldor MK. High-resolution definition of the Vibrio cholerae essential gene set with hidden Markov model-based analyses of transposon-insertion sequencing data. Nucleic Acids Res. 2013 Oct; 41(19):9033-48. PMID: 23901011.
    Citations: 59     Fields:    Translation:Cells
  81. Dörr T, Cava F, Lam H, Davis BM, Waldor MK. Substrate specificity of an elongation-specific peptidoglycan endopeptidase and its implications for cell wall architecture and growth of Vibrio cholerae. Mol Microbiol. 2013 Sep; 89(5):949-62. PMID: 23834664.
    Citations: 20     Fields:    Translation:Cells
  82. Zhou X, Gewurz BE, Ritchie JM, Takasaki K, Greenfeld H, Kieff E, Davis BM, Waldor MK. A Vibrio parahaemolyticus T3SS effector mediates pathogenesis by independently enabling intestinal colonization and inhibiting TAK1 activation. Cell Rep. 2013 May 30; 3(5):1690-702. PMID: 23623501.
    Citations: 25     Fields:    Translation:HumansAnimalsCells
  83. Davis BM, Chao MC, Waldor MK. Entering the era of bacterial epigenomics with single molecule real time DNA sequencing. Curr Opin Microbiol. 2013 Apr; 16(2):192-8. PMID: 23434113.
    Citations: 42     Fields:    Translation:Cells
  84. Davis BM, Waldor MK. Horizontal gene transfer: linking sex and cell fate. Curr Biol. 2013 Feb 04; 23(3):R118-9. PMID: 23391387.
    Citations: 3     Fields:    Translation:Cells
  85. Grad YH, Godfrey P, Cerquiera GC, Mariani-Kurkdjian P, Gouali M, Bingen E, Shea TP, Haas BJ, Griggs A, Young S, Zeng Q, Lipsitch M, Waldor MK, Weill FX, Wortman JR, Hanage WP. Comparative genomics of recent Shiga toxin-producing Escherichia coli O104:H4: short-term evolution of an emerging pathogen. mBio. 2013 Jan 22; 4(1):e00452-12. PMID: 23341549.
    Citations: 26     Fields:    Translation:HumansCells
  86. Pacheco AR, Curtis MM, Ritchie JM, Munera D, Waldor MK, Moreira CG, Sperandio V. Fucose sensing regulates bacterial intestinal colonization. Nature. 2012 Dec 06; 492(7427):113-7. PMID: 23160491.
    Citations: 149     Fields:    Translation:AnimalsCells
  87. Fang G, Munera D, Friedman DI, Mandlik A, Chao MC, Banerjee O, Feng Z, Losic B, Mahajan MC, Jabado OJ, Deikus G, Clark TA, Luong K, Murray IA, Davis BM, Keren-Paz A, Chess A, Roberts RJ, Korlach J, Turner SW, Kumar V, Waldor MK, Schadt EE. Genome-wide mapping of methylated adenine residues in pathogenic Escherichia coli using single-molecule real-time sequencing. Nat Biotechnol. 2012 Dec; 30(12):1232-9. PMID: 23138224.
    Citations: 121     Fields:    Translation:Cells
  88. Yamaichi Y, Bruckner R, Ringgaard S, Möll A, Cameron DE, Briegel A, Jensen GJ, Davis BM, Waldor MK. A multidomain hub anchors the chromosome segregation and chemotactic machinery to the bacterial pole. Genes Dev. 2012 Oct 15; 26(20):2348-60. PMID: 23070816.
    Citations: 62     Fields:    Translation:Cells
  89. Mekalanos JJ, Robins W, Ussery DW, Davis BM, Schadt E, Waldor MK. Non-O1 Vibrio cholerae unlinked to cholera in Haiti. Proc Natl Acad Sci U S A. 2012 Nov 20; 109(47):E3206; author reply E3207. PMID: 23035253.
    Citations: 4     Fields:    Translation:HumansCellsPHPublic Health
  90. Ford CG, Kolappan S, Phan HT, Waldor MK, Winther-Larsen HC, Craig L. Crystal structures of a CTXphi pIII domain unbound and in complex with a Vibrio cholerae TolA domain reveal novel interaction interfaces. J Biol Chem. 2012 Oct 19; 287(43):36258-72. PMID: 22942280.
    Citations: 6     Fields:    Translation:HumansCells
  91. Hatzios SK, Ringgaard S, Davis BM, Waldor MK. Studies of dynamic protein-protein interactions in bacteria using Renilla luciferase complementation are undermined by nonspecific enzyme inhibition. PLoS One. 2012; 7(8):e43175. PMID: 22905225.
    Citations: 8     Fields:    Translation:AnimalsCells
  92. Bashir A, Klammer A, Robins WP, Chin CS, Webster D, Paxinos E, Hsu D, Ashby M, Wang S, Peluso P, Sebra R, Sorenson J, Bullard J, Yen J, Valdovino M, Mollova E, Luong K, Lin S, LaMay B, Joshi A, Rowe L, Frace M, Tarr CL, Turnsek M, Davis BM, Kasarskis A, Mekalanos JJ, Waldor MK, Schadt EE. A hybrid approach for the automated finishing of bacterial genomes. Nat Biotechnol. 2012 Jul 01; 30(7):701-707. PMID: 22750883.
    Citations: 70     Fields:    Translation:Cells
  93. Zhou X, Ritchie JM, Hiyoshi H, Iida T, Davis BM, Waldor MK, Kodama T. The hydrophilic translocator for Vibrio parahaemolyticus, T3SS2, is also translocated. Infect Immun. 2012 Aug; 80(8):2940-7. PMID: 22585964.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  94. Ritchie JM, Rui H, Zhou X, Iida T, Kodoma T, Ito S, Davis BM, Bronson RT, Waldor MK. Inflammation and disintegration of intestinal villi in an experimental model for Vibrio parahaemolyticus-induced diarrhea. PLoS Pathog. 2012; 8(3):e1002593. PMID: 22438811.
    Citations: 66     Fields:    Translation:AnimalsCells
  95. Lloyd SJ, Ritchie JM, Rojas-Lopez M, Blumentritt CA, Popov VL, Greenwich JL, Waldor MK, Torres AG. A double, long polar fimbria mutant of Escherichia coli O157:H7 expresses Curli and exhibits reduced in vivo colonization. Infect Immun. 2012 Mar; 80(3):914-20. PMID: 22232190.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
  96. Ritchie JM, Greenwich JL, Davis BM, Bronson RT, Gebhart D, Williams SR, Martin D, Scholl D, Waldor MK. An Escherichia coli O157-specific engineered pyocin prevents and ameliorates infection by E. coli O157:H7 in an animal model of diarrheal disease. Antimicrob Agents Chemother. 2011 Dec; 55(12):5469-74. PMID: 21947394.
    Citations: 18     Fields:    Translation:HumansAnimalsCells
  97. Mandlik A, Livny J, Robins WP, Ritchie JM, Mekalanos JJ, Waldor MK. RNA-Seq-based monitoring of infection-linked changes in Vibrio cholerae gene expression. . 2011 Aug 18; 10(2):165-74. PMID: 21843873.
    Citations: 106     Translation:AnimalsCells
  98. Rasko DA, Webster DR, Sahl JW, Bashir A, Boisen N, Scheutz F, Paxinos EE, Sebra R, Chin CS, Iliopoulos D, Klammer A, Peluso P, Lee L, Kislyuk AO, Bullard J, Kasarskis A, Wang S, Eid J, Rank D, Redman JC, Steyert SR, Frimodt-Møller J, Struve C, Petersen AM, Krogfelt KA, Nataro JP, Schadt EE, Waldor MK. Origins of the E. coli strain causing an outbreak of hemolytic-uremic syndrome in Germany. N Engl J Med. 2011 Aug 25; 365(8):709-17. PMID: 21793740.
    Citations: 312     Fields:    Translation:HumansCellsPHPublic Health
  99. Cava F, de Pedro MA, Lam H, Davis BM, Waldor MK. Distinct pathways for modification of the bacterial cell wall by non-canonical D-amino acids. EMBO J. 2011 Jul 26; 30(16):3442-53. PMID: 21792174.
    Citations: 91     Fields:    Translation:Cells
  100. Yamaichi Y, Gerding MA, Davis BM, Waldor MK. Regulatory cross-talk links Vibrio cholerae chromosome II replication and segregation. PLoS Genet. 2011 Jul; 7(7):e1002189. PMID: 21811418.
    Citations: 22     Fields:    Translation:Cells
  101. Ringgaard S, Schirner K, Davis BM, Waldor MK. A family of ParA-like ATPases promotes cell pole maturation by facilitating polar localization of chemotaxis proteins. Genes Dev. 2011 Jul 15; 25(14):1544-55. PMID: 21764856.
    Citations: 35     Fields:    Translation:AnimalsCells
  102. Shin OS, Tam VC, Suzuki M, Ritchie JM, Bronson RT, Waldor MK, Mekalanos JJ. Type III secretion is essential for the rapidly fatal diarrheal disease caused by non-O1, non-O139 Vibrio cholerae. mBio. 2011; 2(3):e00106-11. PMID: 21673189.
    Citations: 31     Fields:    Translation:AnimalsCells
  103. Farmer P, Almazor CP, Bahnsen ET, Barry D, Bazile J, Bloom BR, Bose N, Brewer T, Calderwood SB, Clemens JD, Cravioto A, Eustache E, Jérôme G, Gupta N, Harris JB, Hiatt HH, Holstein C, Hotez PJ, Ivers LC, Kerry VB, Koenig SP, Larocque RC, Léandre F, Lambert W, Lyon E, Mekalanos JJ, Mukherjee JS, Oswald C, Pape JW, Gretchko Prosper A, Rabinovich R, Raymonville M, Réjouit JR, Ronan LJ, Rosenberg ML, Ryan ET, Sachs JD, Sack DA, Surena C, Suri AA, Ternier R, Waldor MK, Walton D, Weigel JL. Meeting cholera's challenge to Haiti and the world: a joint statement on cholera prevention and care. PLoS Negl Trop Dis. 2011; 5(5):e1145. PMID: 21655350.
    Citations: 29     Fields:    Translation:HumansPHPublic Health
  104. Cava F, Lam H, de Pedro MA, Waldor MK. Emerging knowledge of regulatory roles of D-amino acids in bacteria. Cell Mol Life Sci. 2011 Mar; 68(5):817-31. PMID: 21161322.
    Citations: 71     Fields:    Translation:Cells
  105. Chin CS, Sorenson J, Harris JB, Robins WP, Charles RC, Jean-Charles RR, Bullard J, Webster DR, Kasarskis A, Peluso P, Paxinos EE, Yamaichi Y, Calderwood SB, Mekalanos JJ, Schadt EE, Waldor MK. The origin of the Haitian cholera outbreak strain. N Engl J Med. 2011 Jan 06; 364(1):33-42. PMID: 21142692.
    Citations: 264     Fields:    Translation:HumansCellsPHPublic Health
  106. Yuan J, Yamaichi Y, Waldor MK. The three vibrio cholerae chromosome II-encoded ParE toxins degrade chromosome I following loss of chromosome II. J Bacteriol. 2011 Feb; 193(3):611-9. PMID: 21115657.
    Citations: 20     Fields:    Translation:Cells
  107. Waldor MK, Hotez PJ, Clemens JD. A national cholera vaccine stockpile--a new humanitarian and diplomatic resource. N Engl J Med. 2010 Dec 09; 363(24):2279-82. PMID: 21105832.
    Citations: 15     Fields:    Translation:HumansPHPublic Health
  108. Waldor MK. Mobilizable genomic islands: going mobile with oriT mimicry. Mol Microbiol. 2010 Nov; 78(3):537-40. PMID: 21038479.
    Citations: 9     Fields:    Translation:Cells
  109. Yuan J, Sterckx Y, Mitchenall LA, Maxwell A, Loris R, Waldor MK. Vibrio cholerae ParE2 poisons DNA gyrase via a mechanism distinct from other gyrase inhibitors. J Biol Chem. 2010 Dec 17; 285(51):40397-408. PMID: 20952390.
    Citations: 20     Fields:    Translation:HumansCells
  110. Le Roux F, Davis BM, Waldor MK. Conserved small RNAs govern replication and incompatibility of a diverse new plasmid family from marine bacteria. Nucleic Acids Res. 2011 Feb; 39(3):1004-13. PMID: 20923782.
    Citations: 11     Fields:    Translation:Cells
  111. Le Roux F, Labreuche Y, Davis BM, Iqbal N, Mangenot S, Goarant C, Mazel D, Waldor MK. Virulence of an emerging pathogenic lineage of Vibrio nigripulchritudo is dependent on two plasmids. Environ Microbiol. 2011 Feb; 13(2):296-306. PMID: 20825454.
    Citations: 18     Fields:    Translation:AnimalsCells
  112. Wozniak RA, Waldor MK. Integrative and conjugative elements: mosaic mobile genetic elements enabling dynamic lateral gene flow. Nat Rev Microbiol. 2010 Aug; 8(8):552-63. PMID: 20601965.
    Citations: 236     Fields:    Translation:Cells
  113. Ritchie JM, Rui H, Bronson RT, Waldor MK. Back to the future: studying cholera pathogenesis using infant rabbits. mBio. 2010 May 18; 1(1). PMID: 20689747.
    Citations: 53     Fields:    
  114. Hui MP, Galkin VE, Yu X, Stasiak AZ, Stasiak A, Waldor MK, Egelman EH. ParA2, a Vibrio cholerae chromosome partitioning protein, forms left-handed helical filaments on DNA. Proc Natl Acad Sci U S A. 2010 Mar 09; 107(10):4590-5. PMID: 20176965.
    Citations: 27     Fields:    Translation:Cells
  115. Rui H, Ritchie JM, Bronson RT, Mekalanos JJ, Zhang Y, Waldor MK. Reactogenicity of live-attenuated Vibrio cholerae vaccines is dependent on flagellins. Proc Natl Acad Sci U S A. 2010 Mar 02; 107(9):4359-64. PMID: 20160087.
    Citations: 32     Fields:    Translation:AnimalsCells
  116. Wozniak RA, Fouts DE, Spagnoletti M, Colombo MM, Ceccarelli D, Garriss G, Déry C, Burrus V, Waldor MK. Comparative ICE genomics: insights into the evolution of the SXT/R391 family of ICEs. PLoS Genet. 2009 Dec; 5(12):e1000786. PMID: 20041216.
    Citations: 105     Fields:    Translation:Cells
  117. Garriss G, Waldor MK, Burrus V. Mobile antibiotic resistance encoding elements promote their own diversity. PLoS Genet. 2009 Dec; 5(12):e1000775. PMID: 20019796.
    Citations: 46     Fields: