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profileMatthew K Waldor, M.D., Ph.D.

TitleEdward H. Kass Professor of Medicine
InstitutionBrigham and Women's Hospital
DepartmentMedicine
AddressChanning Laboratory
Mcp-769
181 Longwood Ave
Boston MA 02115
Phone617/525-4646
Fax617/525-4660
vCardDownload vCard (login for email)
Other Positions
TitleProfessor in the Department of Immunology and Infectious Diseases
InstitutionHarvard T.H. Chan School of Public Health
DepartmentImmunology and Infectious Diseases


Collapse Mentoring 
Collapse current student opportunities
Available: 09/01/17, Expires: 08/31/19

The student will conduct a genome-wide screen to identify pathogen or host genes that contribute to pathogenesis of diseases caused by enteric pathogens. The student will be engaged in all steps of the project from creation of mutant libraries to analyses of the big data that screens generate. Some experience in molecular biology is preferable.


Collapse Research 
Collapse research activities and funding
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
Most Recent  |  List All
R21AI067827     (WALDOR, MATTHEW K)Feb 1, 2006 - Jan 31, 2009
NIH/NIAID
Intestinal colonization of Enterohemorrhagic E. coil
Role: Principal Investigator
R21AI059698     (WALDOR, MATTHEW K)Apr 1, 2004 - Mar 31, 2007
NIH/NIAID
Role of Hfq in Vibrio cholerae virulence
Role: Principal Investigator
R37AI042347     (WALDOR, MATTHEW K)Jan 1, 1998 - Dec 31, 2017
NIH/NIAID
Molecular Biology and Virulence of CTX Phage
Role: Principal Investigator
R01AI042347     (WALDOR, MATTHEW K)Jan 1, 1998 - Dec 31, 2007
NIH/NIAID
Molecular Biology and Virulence of CTX Phage
Role: Principal Investigator
K08AI001321     (WALDOR, MATTHEW K)Aug 1, 1995 - Jul 31, 1998
NIH/NIAID
IDENTIFICATION OF VIRULENCE GENES IN VIBRIO CHOLERAE
Role: Principal Investigator

Collapse Bibliographic 
Collapse selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Zhang T, Abel S, Abel Zur Wiesch P, Sasabe J, Davis BM, Higgins DE, Waldor MK. Deciphering the landscape of host barriers to Listeria monocytogenes infection. Proc Natl Acad Sci U S A. 2017 Jun 13; 114(24):6334-6339. PMID: 28559314.
    View in: PubMed
  2. Orlova N, Gerding M, Ivashkiv O, Olinares PDB, Chait BT, Waldor MK, Jeruzalmi D. The replication initiator of the cholera pathogen's second chromosome shows structural similarity to plasmid initiators. Nucleic Acids Res. 2017 Apr 20; 45(7):3724-3737. PMID: 28031373.
    View in: PubMed
  3. Kimura S, Hubbard TP, Davis BM, Waldor MK. The Nucleoid Binding Protein H-NS Biases Genome-Wide Transposon Insertion Landscapes. MBio. 2016 Aug 30; 7(4). PMID: 27578758; PMCID: PMC4999555.
    View in: PubMed, PubMed Central
  4. Sasabe J, Miyoshi Y, Rakoff-Nahoum S, Zhang T, Mita M, Davis BM, Hamase K, Waldor MK. Interplay between microbial d-amino acids and host d-amino acid oxidase modifies murine mucosal defence and gut microbiota. Nat Microbiol. 2016 Jul 25; 1(10):16125. PMID: 27670111.
    View in: PubMed
  5. Dörr T, Delgado F, Umans BD, Gerding MA, Davis BM, Waldor MK. A Transposon Screen Identifies Genetic Determinants of Vibrio cholerae Resistance to High-Molecular-Weight Antibiotics. Antimicrob Agents Chemother. 2016 Aug; 60(8):4757-63. PMID: 27216069; PMCID: PMC4958186 [Available on 02/01/17].
    View in: PubMed, PubMed Central
  6. Blondel CJ, Park JS, Hubbard TP, Pacheco AR, Kuehl CJ, Walsh MJ, Davis BM, Gewurz BE, Doench JG, Waldor MK. CRISPR/Cas9 Screens Reveal Requirements for Host Cell Sulfation and Fucosylation in Bacterial Type III Secretion System-Mediated Cytotoxicity. Cell Host Microbe. 2016 Aug 10; 20(2):226-37. PMID: 27453484; PMCID: PMC4982808 [Available on 08/10/17].
    View in: PubMed, PubMed Central
  7. Moreira CG, Russell R, Mishra AA, Narayanan S, Ritchie JM, Waldor MK, Curtis MM, Winter SE, Weinshenker D, Sperandio V. Bacterial Adrenergic Sensors Regulate Virulence of Enteric Pathogens in the Gut. MBio. 2016 Jun 07; 7(3). PMID: 27273829; PMCID: PMC4959670.
    View in: PubMed, PubMed Central
  8. Rajpurohit YS, Bihani SC, Waldor MK, Misra HS. Phosphorylation of Deinococcus radiodurans RecA Regulates Its Activity and May Contribute to Radioresistance. J Biol Chem. 2016 Aug 05; 291(32):16672-85. PMID: 27255712; PMCID: PMC4974381 [Available on 08/05/17].
    View in: PubMed, PubMed Central
  9. Hatzios SK, Abel S, Martell J, Hubbard T, Sasabe J, Munera D, Clark L, Bachovchin DA, Qadri F, Ryan ET, Davis BM, Weerapana E, Waldor MK. Erratum: Chemoproteomic profiling of host and pathogen enzymes active in cholera. Nat Chem Biol. 2016 May 18; 12(6):466. PMID: 27191648.
    View in: PubMed
  10. Hubbard TP, Chao MC, Abel S, Blondel CJ, Abel Zur Wiesch P, Zhou X, Davis BM, Waldor MK. Genetic analysis of Vibrio parahaemolyticus intestinal colonization. Proc Natl Acad Sci U S A. 2016 May 31; 113(22):6283-8. PMID: 27185914; PMCID: PMC4896720 [Available on 11/30/16].
    View in: PubMed, PubMed Central
  11. Hatzios SK, Abel S, Martell J, Hubbard T, Sasabe J, Munera D, Clark L, Bachovchin DA, Qadri F, Ryan ET, Davis BM, Weerapana E, Waldor MK. Chemoproteomic profiling of host and pathogen enzymes active in cholera. Nat Chem Biol. 2016 Apr; 12(4):268-274. PMID: 26900865; PMCID: PMC4765928.
    View in: PubMed, PubMed Central
  12. Chao MC, Abel S, Davis BM, Waldor MK. The design and analysis of transposon insertion sequencing experiments. Nat Rev Microbiol. 2016 02; 14(2):119-28. PMID: 26775926.
    View in: PubMed
  13. Dörr T, Alvarez L, Delgado F, Davis BM, Cava F, Waldor MK. A cell wall damage response mediated by a sensor kinase/response regulator pair enables beta-lactam tolerance. Proc Natl Acad Sci U S A. 2016 Jan 12; 113(2):404-9. PMID: 26712007; PMCID: PMC4720315.
    View in: PubMed, PubMed Central
  14. Chao MC, Zhu S, Kimura S, Davis BM, Schadt EE, Fang G, Waldor MK. Correction: A Cytosine Methytransferase Modulates the Cell Envelope Stress Response in the Cholera Pathogen. PLoS Genet. 2015 Dec; 11(12):e1005739. PMID: 26657207; PMCID: PMC4747549.
    View in: PubMed, PubMed Central
  15. Chao MC, Zhu S, Kimura S, Davis BM, Schadt EE, Fang G, Waldor MK. A Cytosine Methyltransferase Modulates the Cell Envelope Stress Response in the Cholera Pathogen [corrected]. PLoS Genet. 2015 Nov; 11(11):e1005666. PMID: 26588462; PMCID: PMC4654547.
    View in: PubMed, PubMed Central
  16. Kieser KJ, Baranowski C, Chao MC, Long JE, Sassetti CM, Waldor MK, Sacchettini JC, Ioerger TR, Rubin EJ. Peptidoglycan synthesis in Mycobacterium tuberculosis is organized into networks with varying drug susceptibility. Proc Natl Acad Sci U S A. 2015 Oct 20; 112(42):13087-92. PMID: 26438867; PMCID: PMC4620856.
    View in: PubMed, PubMed Central
  17. Abel S, Waldor MK. Infant Rabbit Model for Diarrheal Diseases. Curr Protoc Microbiol. 2015 Aug 03; 38:6A.6.1-15. PMID: 26237109.
    View in: PubMed
  18. Gerding MA, Chao MC, Davis BM, Waldor MK. Molecular Dissection of the Essential Features of the Origin of Replication of the Second Vibrio cholerae Chromosome. MBio. 2015 Jul 28; 6(4):e00973. PMID: 26220967; PMCID: PMC4551981.
    View in: PubMed, PubMed Central
  19. Osorio CR, Rivas AJ, Balado M, Fuentes-Monteverde JC, Rodríguez J, Jiménez C, Lemos ML, Waldor MK. A Transmissible Plasmid-Borne Pathogenicity Island Confers Piscibactin Biosynthesis in the Fish Pathogen Photobacterium damselae subsp. piscicida. Appl Environ Microbiol. 2015 Sep 01; 81(17):5867-79. PMID: 26092457; PMCID: PMC4551267.
    View in: PubMed, PubMed Central
  20. Beaulaurier J, Zhang XS, Zhu S, Sebra R, Rosenbluh C, Deikus G, Shen N, Munera D, Waldor MK, Chess A, Blaser MJ, Schadt EE, Fang G. Single molecule-level detection and long read-based phasing of epigenetic variations in bacterial methylomes. Nat Commun. 2015 Jun 15; 6:7438. PMID: 26074426; PMCID: PMC4490391.
    View in: PubMed, PubMed Central
  21. Abel S, Abel zur Wiesch P, Davis BM, Waldor MK. Analysis of Bottlenecks in Experimental Models of Infection. PLoS Pathog. 2015 Jun; 11(6):e1004823. PMID: 26066486; PMCID: PMC4465827.
    View in: PubMed, PubMed Central
  22. Wang Q, Millet YA, Chao MC, Sasabe J, Davis BM, Waldor MK. A Genome-Wide Screen Reveals that the Vibrio cholerae Phosphoenolpyruvate Phosphotransferase System Modulates Virulence Gene Expression. Infect Immun. 2015 Sep; 83(9):3381-95. PMID: 26056384; PMCID: PMC4534656.
    View in: PubMed, PubMed Central
  23. Ringgaard S, Hubbard T, Mandlik A, Davis BM, Waldor MK. RpoS and quorum sensing control expression and polar localization of Vibrio cholerae chemotaxis cluster III proteins in vitro and in vivo. Mol Microbiol. 2015 Aug; 97(4):660-75. PMID: 25989366; PMCID: PMC4646612.
    View in: PubMed, PubMed Central
  24. Abel Zur Wiesch P, Abel S, Gkotzis S, Ocampo P, Engelstädter J, Hinkley T, Magnus C, Waldor MK, Udekwu K, Cohen T. Classic reaction kinetics can explain complex patterns of antibiotic action. Sci Transl Med. 2015 May 13; 7(287):287ra73. PMID: 25972005; PMCID: PMC4554720.
    View in: PubMed, PubMed Central
  25. Dörr T, Davis BM, Waldor MK. Endopeptidase-mediated beta lactam tolerance. PLoS Pathog. 2015 Apr; 11(4):e1004850. PMID: 25884840; PMCID: PMC4401780.
    View in: PubMed, PubMed Central
  26. Möll A, Dörr T, Alvarez L, Davis BM, Cava F, Waldor MK. A D, D-carboxypeptidase is required for Vibrio cholerae halotolerance. Environ Microbiol. 2015 Feb; 17(2):527-40. PMID: 25631756; PMCID: PMC4634008.
    View in: PubMed, PubMed Central
  27. Waldor MK, Tyson G, Borenstein E, Ochman H, Moeller A, Finlay BB, Kong HH, Gordon JI, Nelson KE, Dabbagh K, Smith H. Where next for microbiome research? PLoS Biol. 2015 Jan; 13(1):e1002050. PMID: 25602283; PMCID: PMC4300079.
    View in: PubMed, PubMed Central
  28. Abel S, Abel zur Wiesch P, Chang HH, Davis BM, Lipsitch M, Waldor MK. Sequence tag-based analysis of microbial population dynamics. Nat Methods. 2015 Mar; 12(3):223-6, 3 p following 226. PMID: 25599549; PMCID: PMC4344388.
    View in: PubMed, PubMed Central
  29. Yamaichi Y, Chao MC, Sasabe J, Clark L, Davis BM, Yamamoto N, Mori H, Kurokawa K, Waldor MK. High-resolution genetic analysis of the requirements for horizontal transmission of the ESBL plasmid from Escherichia coli O104:H4. Nucleic Acids Res. 2015 Jan; 43(1):348-60. PMID: 25477379; PMCID: PMC4288162.
    View in: PubMed, PubMed Central
  30. Pritchard JR, Chao MC, Abel S, Davis BM, Baranowski C, Zhang YJ, Rubin EJ, Waldor MK. ARTIST: high-resolution genome-wide assessment of fitness using transposon-insertion sequencing. PLoS Genet. 2014 Nov; 10(11):e1004782. PMID: 25375795; PMCID: PMC4222735.
    View in: PubMed, PubMed Central
  31. Millet YA, Alvarez D, Ringgaard S, von Andrian UH, Davis BM, Waldor MK. Insights into Vibrio cholerae intestinal colonization from monitoring fluorescently labeled bacteria. PLoS Pathog. 2014 Oct; 10(10):e1004405. PMID: 25275396; PMCID: PMC4183697.
    View in: PubMed, PubMed Central
  32. Livny J, Zhou X, Mandlik A, Hubbard T, Davis BM, Waldor MK. Comparative RNA-Seq based dissection of the regulatory networks and environmental stimuli underlying Vibrio parahaemolyticus gene expression during infection. Nucleic Acids Res. 2014 Oct 29; 42(19):12212-23. PMID: 25262354; PMCID: PMC4231756.
    View in: PubMed, PubMed Central
  33. Möll A, Dörr T, Alvarez L, Chao MC, Davis BM, Cava F, Waldor MK. Cell separation in Vibrio cholerae is mediated by a single amidase whose action is modulated by two nonredundant activators. J Bacteriol. 2014 Nov; 196(22):3937-48. PMID: 25182499; PMCID: PMC4248829.
    View in: PubMed, PubMed Central
  34. Zhou X, Massol RH, Nakamura F, Chen X, Gewurz BE, Davis BM, Lencer WI, Waldor MK. Remodeling of the intestinal brush border underlies adhesion and virulence of an enteric pathogen. MBio. 2014 Aug 19; 5(4). PMID: 25139905; PMCID: PMC4147867.
    View in: PubMed, PubMed Central
  35. Dörr T, Lam H, Alvarez L, Cava F, Davis BM, Waldor MK. A novel peptidoglycan binding protein crucial for PBP1A-mediated cell wall biogenesis in Vibrio cholerae. PLoS Genet. 2014 Jun; 10(6):e1004433. PMID: 24945690; PMCID: PMC4063736.
    View in: PubMed, PubMed Central
  36. Taylor DL, Bina XR, Slamti L, Waldor MK, Bina JE. Reciprocal regulation of resistance-nodulation-division efflux systems and the Cpx two-component system in Vibrio cholerae. Infect Immun. 2014 Jul; 82(7):2980-91. PMID: 24799626; PMCID: PMC4097637.
    View in: PubMed, PubMed Central
  37. Lu X, Skurnik D, Pozzi C, Roux D, Cywes-Bentley C, Ritchie JM, Munera D, Gening ML, Tsvetkov YE, Nifantiev NE, Waldor MK, Pier GB. A Poly-N-acetylglucosamine-Shiga toxin broad-spectrum conjugate vaccine for Shiga toxin-producing Escherichia coli. MBio. 2014 Mar 25; 5(2):e00974-14. PMID: 24667709; PMCID: PMC3977355.
    View in: PubMed, PubMed Central
  38. Dörr T, Möll A, Chao MC, Cava F, Lam H, Davis BM, Waldor MK. Differential requirement for PBP1a and PBP1b in in vivo and in vitro fitness of Vibrio cholerae. Infect Immun. 2014 May; 82(5):2115-24. PMID: 24614657; PMCID: PMC3993429.
    View in: PubMed, PubMed Central
  39. Kota S, Charaka VK, Ringgaard S, Waldor MK, Misra HS. PprA contributes to Deinococcus radiodurans resistance to nalidixic acid, genome maintenance after DNA damage and interacts with deinococcal topoisomerases. PLoS One. 2014; 9(1):e85288. PMID: 24454836; PMCID: PMC3893189.
    View in: PubMed, PubMed Central
  40. Okada R, Zhou X, Hiyoshi H, Matsuda S, Chen X, Akeda Y, Kashimoto T, Davis BM, Iida T, Waldor MK, Kodama T. The Vibrio parahaemolyticus effector VopC mediates Cdc42-dependent invasion of cultured cells but is not required for pathogenicity in an animal model of infection. Cell Microbiol. 2014 Jun; 16(6):938-47. PMID: 24345190; PMCID: PMC4670550.
    View in: PubMed, PubMed Central
  41. Munera D, Ritchie JM, Hatzios SK, Bronson R, Fang G, Schadt EE, Davis BM, Waldor MK. Autotransporters but not pAA are critical for rabbit colonization by Shiga toxin-producing Escherichia coli O104:H4. Nat Commun. 2014; 5:3080. PMID: 24445323; PMCID: PMC3905246.
    View in: PubMed, PubMed Central
  42. Ringgaard S, Zepeda-Rivera M, Wu X, Schirner K, Davis BM, Waldor MK. ParP prevents dissociation of CheA from chemotactic signaling arrays and tethers them to a polar anchor. Proc Natl Acad Sci U S A. 2014 Jan 14; 111(2):E255-64. PMID: 24379357; PMCID: PMC3896188.
    View in: PubMed, PubMed Central
  43. Espaillat A, Carrasco-López C, Bernardo-García N, Pietrosemoli N, Otero LH, Álvarez L, de Pedro MA, Pazos F, Davis BM, Waldor MK, Hermoso JA, Cava F. Structural basis for the broad specificity of a new family of amino-acid racemases. Acta Crystallogr D Biol Crystallogr. 2014 Jan; 70(Pt 1):79-90. PMID: 24419381; PMCID: PMC4984259.
    View in: PubMed, PubMed Central
  44. Fu Y, Waldor MK, Mekalanos JJ. Tn-Seq analysis of Vibrio cholerae intestinal colonization reveals a role for T6SS-mediated antibacterial activity in the host. Cell Host Microbe. 2013 Dec 11; 14(6):652-63. PMID: 24331463; PMCID: PMC3951154.
    View in: PubMed, PubMed Central
  45. Grad YH, Waldor MK. Deciphering the origins and tracking the evolution of cholera epidemics with whole-genome-based molecular epidemiology. MBio. 2013 Sep 10; 4(5):e00670-13. PMID: 24023387; PMCID: PMC3774194.
    View in: PubMed, PubMed Central
  46. Davis BM, Waldor MK. Establishing polar identity in gram-negative rods. Curr Opin Microbiol. 2013 Dec; 16(6):752-9. PMID: 24029491; PMCID: PMC3856201.
    View in: PubMed, PubMed Central
  47. Chao MC, Pritchard JR, Zhang YJ, Rubin EJ, Livny J, Davis BM, Waldor MK. High-resolution definition of the Vibrio cholerae essential gene set with hidden Markov model-based analyses of transposon-insertion sequencing data. Nucleic Acids Res. 2013 Oct; 41(19):9033-48. PMID: 23901011; PMCID: PMC3799429.
    View in: PubMed, PubMed Central
  48. Dörr T, Cava F, Lam H, Davis BM, Waldor MK. Substrate specificity of an elongation-specific peptidoglycan endopeptidase and its implications for cell wall architecture and growth of Vibrio cholerae. Mol Microbiol. 2013 Sep; 89(5):949-62. PMID: 23834664; PMCID: PMC3769093.
    View in: PubMed, PubMed Central
  49. Zhou X, Gewurz BE, Ritchie JM, Takasaki K, Greenfeld H, Kieff E, Davis BM, Waldor MK. A Vibrio parahaemolyticus T3SS effector mediates pathogenesis by independently enabling intestinal colonization and inhibiting TAK1 activation. Cell Rep. 2013 May 30; 3(5):1690-702. PMID: 23623501; PMCID: PMC3711673.
    View in: PubMed, PubMed Central
  50. Davis BM, Chao MC, Waldor MK. Entering the era of bacterial epigenomics with single molecule real time DNA sequencing. Curr Opin Microbiol. 2013 Apr; 16(2):192-8. PMID: 23434113; PMCID: PMC3646917.
    View in: PubMed, PubMed Central
  51. Davis BM, Waldor MK. Horizontal gene transfer: linking sex and cell fate. Curr Biol. 2013 Feb 04; 23(3):R118-9. PMID: 23391387.
    View in: PubMed
  52. Grad YH, Godfrey P, Cerquiera GC, Mariani-Kurkdjian P, Gouali M, Bingen E, Shea TP, Haas BJ, Griggs A, Young S, Zeng Q, Lipsitch M, Waldor MK, Weill FX, Wortman JR, Hanage WP. Comparative genomics of recent Shiga toxin-producing Escherichia coli O104:H4: short-term evolution of an emerging pathogen. MBio. 2013 Jan 22; 4(1):e00452-12. PMID: 23341549; PMCID: PMC3551546.
    View in: PubMed, PubMed Central
  53. Pacheco AR, Curtis MM, Ritchie JM, Munera D, Waldor MK, Moreira CG, Sperandio V. Fucose sensing regulates bacterial intestinal colonization. Nature. 2012 Dec 06; 492(7427):113-7. PMID: 23160491; PMCID: PMC3518558.
    View in: PubMed, PubMed Central
  54. Fang G, Munera D, Friedman DI, Mandlik A, Chao MC, Banerjee O, Feng Z, Losic B, Mahajan MC, Jabado OJ, Deikus G, Clark TA, Luong K, Murray IA, Davis BM, Keren-Paz A, Chess A, Roberts RJ, Korlach J, Turner SW, Kumar V, Waldor MK, Schadt EE. Genome-wide mapping of methylated adenine residues in pathogenic Escherichia coli using single-molecule real-time sequencing. Nat Biotechnol. 2012 Dec; 30(12):1232-9. PMID: 23138224; PMCID: PMC3879109.
    View in: PubMed, PubMed Central
  55. Yamaichi Y, Bruckner R, Ringgaard S, Möll A, Cameron DE, Briegel A, Jensen GJ, Davis BM, Waldor MK. A multidomain hub anchors the chromosome segregation and chemotactic machinery to the bacterial pole. Genes Dev. 2012 Oct 15; 26(20):2348-60. PMID: 23070816; PMCID: PMC3475806.
    View in: PubMed, PubMed Central
  56. Mekalanos JJ, Robins W, Ussery DW, Davis BM, Schadt E, Waldor MK. Non-O1 Vibrio cholerae unlinked to cholera in Haiti. Proc Natl Acad Sci U S A. 2012 Nov 20; 109(47):E3206; author reply E3207. PMID: 23035253; PMCID: PMC3511112.
    View in: PubMed, PubMed Central
  57. Ford CG, Kolappan S, Phan HT, Waldor MK, Winther-Larsen HC, Craig L. Crystal structures of a CTXphi pIII domain unbound and in complex with a Vibrio cholerae TolA domain reveal novel interaction interfaces. J Biol Chem. 2012 Oct 19; 287(43):36258-72. PMID: 22942280; PMCID: PMC3476293.
    View in: PubMed, PubMed Central
  58. Hatzios SK, Ringgaard S, Davis BM, Waldor MK. Studies of dynamic protein-protein interactions in bacteria using Renilla luciferase complementation are undermined by nonspecific enzyme inhibition. PLoS One. 2012; 7(8):e43175. PMID: 22905225; PMCID: PMC3419657.
    View in: PubMed, PubMed Central
  59. Bashir A, Klammer A, Robins WP, Chin CS, Webster D, Paxinos E, Hsu D, Ashby M, Wang S, Peluso P, Sebra R, Sorenson J, Bullard J, Yen J, Valdovino M, Mollova E, Luong K, Lin S, LaMay B, Joshi A, Rowe L, Frace M, Tarr CL, Turnsek M, Davis BM, Kasarskis A, Mekalanos JJ, Waldor MK, Schadt EE. A hybrid approach for the automated finishing of bacterial genomes. Nat Biotechnol. 2012 Jul 01; 30(7):701-707. PMID: 22750883; PMCID: PMC3731737.
    View in: PubMed, PubMed Central
  60. Zhou X, Ritchie JM, Hiyoshi H, Iida T, Davis BM, Waldor MK, Kodama T. The hydrophilic translocator for Vibrio parahaemolyticus, T3SS2, is also translocated. Infect Immun. 2012 Aug; 80(8):2940-7. PMID: 22585964; PMCID: PMC3434562.
    View in: PubMed, PubMed Central
  61. Ritchie JM, Rui H, Zhou X, Iida T, Kodoma T, Ito S, Davis BM, Bronson RT, Waldor MK. Inflammation and disintegration of intestinal villi in an experimental model for Vibrio parahaemolyticus-induced diarrhea. PLoS Pathog. 2012; 8(3):e1002593. PMID: 22438811; PMCID: PMC3305451.
    View in: PubMed, PubMed Central
  62. Lloyd SJ, Ritchie JM, Rojas-Lopez M, Blumentritt CA, Popov VL, Greenwich JL, Waldor MK, Torres AG. A double, long polar fimbria mutant of Escherichia coli O157:H7 expresses Curli and exhibits reduced in vivo colonization. Infect Immun. 2012 Mar; 80(3):914-20. PMID: 22232190; PMCID: PMC3294650.
    View in: PubMed, PubMed Central
  63. Ritchie JM, Greenwich JL, Davis BM, Bronson RT, Gebhart D, Williams SR, Martin D, Scholl D, Waldor MK. An Escherichia coli O157-specific engineered pyocin prevents and ameliorates infection by E. coli O157:H7 in an animal model of diarrheal disease. Antimicrob Agents Chemother. 2011 Dec; 55(12):5469-74. PMID: 21947394; PMCID: PMC3232761.
    View in: PubMed, PubMed Central
  64. Mandlik A, Livny J, Robins WP, Ritchie JM, Mekalanos JJ, Waldor MK. RNA-Seq-based monitoring of infection-linked changes in Vibrio cholerae gene expression. Cell Host Microbe. 2011 Aug 18; 10(2):165-74. PMID: 21843873; PMCID: PMC3166260.
    View in: PubMed, PubMed Central
  65. Rasko DA, Webster DR, Sahl JW, Bashir A, Boisen N, Scheutz F, Paxinos EE, Sebra R, Chin CS, Iliopoulos D, Klammer A, Peluso P, Lee L, Kislyuk AO, Bullard J, Kasarskis A, Wang S, Eid J, Rank D, Redman JC, Steyert SR, Frimodt-Møller J, Struve C, Petersen AM, Krogfelt KA, Nataro JP, Schadt EE, Waldor MK. Origins of the E. coli strain causing an outbreak of hemolytic-uremic syndrome in Germany. N Engl J Med. 2011 Aug 25; 365(8):709-17. PMID: 21793740; PMCID: PMC3168948.
    View in: PubMed, PubMed Central
  66. Cava F, de Pedro MA, Lam H, Davis BM, Waldor MK. Distinct pathways for modification of the bacterial cell wall by non-canonical D-amino acids. EMBO J. 2011 Jul 26; 30(16):3442-53. PMID: 21792174; PMCID: PMC3160665.
    View in: PubMed, PubMed Central
  67. Yamaichi Y, Gerding MA, Davis BM, Waldor MK. Regulatory cross-talk links Vibrio cholerae chromosome II replication and segregation. PLoS Genet. 2011 Jul; 7(7):e1002189. PMID: 21811418; PMCID: PMC3141006.
    View in: PubMed, PubMed Central
  68. Ringgaard S, Schirner K, Davis BM, Waldor MK. A family of ParA-like ATPases promotes cell pole maturation by facilitating polar localization of chemotaxis proteins. Genes Dev. 2011 Jul 15; 25(14):1544-55. PMID: 21764856; PMCID: PMC3143943.
    View in: PubMed, PubMed Central
  69. Shin OS, Tam VC, Suzuki M, Ritchie JM, Bronson RT, Waldor MK, Mekalanos JJ. Type III secretion is essential for the rapidly fatal diarrheal disease caused by non-O1, non-O139 Vibrio cholerae. MBio. 2011; 2(3):e00106-11. PMID: 21673189; PMCID: PMC3111608.
    View in: PubMed, PubMed Central
  70. Farmer P, Almazor CP, Bahnsen ET, Barry D, Bazile J, Bloom BR, Bose N, Brewer T, Calderwood SB, Clemens JD, Cravioto A, Eustache E, Jérôme G, Gupta N, Harris JB, Hiatt HH, Holstein C, Hotez PJ, Ivers LC, Kerry VB, Koenig SP, Larocque RC, Léandre F, Lambert W, Lyon E, Mekalanos JJ, Mukherjee JS, Oswald C, Pape JW, Gretchko Prosper A, Rabinovich R, Raymonville M, Réjouit JR, Ronan LJ, Rosenberg ML, Ryan ET, Sachs JD, Sack DA, Surena C, Suri AA, Ternier R, Waldor MK, Walton D, Weigel JL. Meeting cholera's challenge to Haiti and the world: a joint statement on cholera prevention and care. PLoS Negl Trop Dis. 2011; 5(5):e1145. PMID: 21655350; PMCID: PMC3104956.
    View in: PubMed, PubMed Central
  71. Cava F, Lam H, de Pedro MA, Waldor MK. Emerging knowledge of regulatory roles of D-amino acids in bacteria. Cell Mol Life Sci. 2011 Mar; 68(5):817-31. PMID: 21161322; PMCID: PMC3037491.
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  72. Chin CS, Sorenson J, Harris JB, Robins WP, Charles RC, Jean-Charles RR, Bullard J, Webster DR, Kasarskis A, Peluso P, Paxinos EE, Yamaichi Y, Calderwood SB, Mekalanos JJ, Schadt EE, Waldor MK. The origin of the Haitian cholera outbreak strain. N Engl J Med. 2011 Jan 06; 364(1):33-42. PMID: 21142692; PMCID: PMC3030187.
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  75. Waldor MK. Mobilizable genomic islands: going mobile with oriT mimicry. Mol Microbiol. 2010 Nov; 78(3):537-40. PMID: 21038479; PMCID: PMC3058610.
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  76. Yuan J, Sterckx Y, Mitchenall LA, Maxwell A, Loris R, Waldor MK. Vibrio cholerae ParE2 poisons DNA gyrase via a mechanism distinct from other gyrase inhibitors. J Biol Chem. 2010 Dec 17; 285(51):40397-408. PMID: 20952390; PMCID: PMC3001019.
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  77. Le Roux F, Davis BM, Waldor MK. Conserved small RNAs govern replication and incompatibility of a diverse new plasmid family from marine bacteria. Nucleic Acids Res. 2011 Feb; 39(3):1004-13. PMID: 20923782; PMCID: PMC3035462.
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  78. Le Roux F, Labreuche Y, Davis BM, Iqbal N, Mangenot S, Goarant C, Mazel D, Waldor MK. Virulence of an emerging pathogenic lineage of Vibrio nigripulchritudo is dependent on two plasmids. Environ Microbiol. 2011 Feb; 13(2):296-306. PMID: 20825454; PMCID: PMC3020234.
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  79. Wozniak RA, Waldor MK. Integrative and conjugative elements: mosaic mobile genetic elements enabling dynamic lateral gene flow. Nat Rev Microbiol. 2010 Aug; 8(8):552-63. PMID: 20601965.
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  80. Ritchie JM, Rui H, Bronson RT, Waldor MK. Back to the future: studying cholera pathogenesis using infant rabbits. MBio. 2010 May 18; 1(1). PMID: 20689747; PMCID: PMC2912669.
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  81. Hui MP, Galkin VE, Yu X, Stasiak AZ, Stasiak A, Waldor MK, Egelman EH. ParA2, a Vibrio cholerae chromosome partitioning protein, forms left-handed helical filaments on DNA. Proc Natl Acad Sci U S A. 2010 Mar 09; 107(10):4590-5. PMID: 20176965; PMCID: PMC2842031.
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  82. Rui H, Ritchie JM, Bronson RT, Mekalanos JJ, Zhang Y, Waldor MK. Reactogenicity of live-attenuated Vibrio cholerae vaccines is dependent on flagellins. Proc Natl Acad Sci U S A. 2010 Mar 02; 107(9):4359-64. PMID: 20160087; PMCID: PMC2840140.
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  83. Wozniak RA, Fouts DE, Spagnoletti M, Colombo MM, Ceccarelli D, Garriss G, Déry C, Burrus V, Waldor MK. Comparative ICE genomics: insights into the evolution of the SXT/R391 family of ICEs. PLoS Genet. 2009 Dec; 5(12):e1000786. PMID: 20041216; PMCID: PMC2791158.
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  84. Garriss G, Waldor MK, Burrus V. Mobile antibiotic resistance encoding elements promote their own diversity. PLoS Genet. 2009 Dec; 5(12):e1000775. PMID: 20019796; PMCID: PMC2786100.
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  85. Livny J, Waldor MK. Mining regulatory 5'UTRs from cDNA deep sequencing datasets. Nucleic Acids Res. 2010 Mar; 38(5):1504-14. PMID: 19969537; PMCID: PMC2836559.
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  86. Yamaichi Y, Duigou S, Shakhnovich EA, Waldor MK. Targeting the replication initiator of the second Vibrio chromosome: towards generation of vibrionaceae-specific antimicrobial agents. PLoS Pathog. 2009 Nov; 5(11):e1000663. PMID: 19936046; PMCID: PMC2773409.
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  87. Lam H, Oh DC, Cava F, Takacs CN, Clardy J, de Pedro MA, Waldor MK. D-amino acids govern stationary phase cell wall remodeling in bacteria. Science. 2009 Sep 18; 325(5947):1552-5. PMID: 19762646; PMCID: PMC2759711.
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  88. Shakhnovich EA, Davis BM, Waldor MK. Hfq negatively regulates type III secretion in EHEC and several other pathogens. Mol Microbiol. 2009 Oct; 74(2):347-63. PMID: 19703108; PMCID: PMC2765575.
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  89. Kimsey HH, Waldor MK. Vibrio cholerae LexA coordinates CTX prophage gene expression. J Bacteriol. 2009 Nov; 191(22):6788-95. PMID: 19666711; PMCID: PMC2772474.
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  90. Davis BM, Waldor MK. High-throughput sequencing reveals suppressors of Vibrio cholerae rpoE mutations: one fewer porin is enough. Nucleic Acids Res. 2009 Sep; 37(17):5757-67. PMID: 19620211; PMCID: PMC2761261.
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  91. Kulasekara BR, Jacobs M, Zhou Y, Wu Z, Sims E, Saenphimmachak C, Rohmer L, Ritchie JM, Radey M, McKevitt M, Freeman TL, Hayden H, Haugen E, Gillett W, Fong C, Chang J, Beskhlebnaya V, Waldor MK, Samadpour M, Whittam TS, Kaul R, Brittnacher M, Miller SI. Analysis of the genome of the Escherichia coli O157:H7 2006 spinach-associated outbreak isolate indicates candidate genes that may enhance virulence. Infect Immun. 2009 Sep; 77(9):3713-21. PMID: 19564389; PMCID: PMC2738036.
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  92. Slamti L, Waldor MK. Genetic analysis of activation of the Vibrio cholerae Cpx pathway. J Bacteriol. 2009 Aug; 191(16):5044-56. PMID: 19542291; PMCID: PMC2725601.
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  93. Grall N, Livny J, Waldor M, Barel M, Charbit A, Meibom KL. Pivotal role of the Francisella tularensis heat-shock sigma factor RpoH. Microbiology. 2009 Aug; 155(Pt 8):2560-72. PMID: 19443547; PMCID: PMC2888120.
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  94. Wozniak RA, Waldor MK. A toxin-antitoxin system promotes the maintenance of an integrative conjugative element. PLoS Genet. 2009 Mar; 5(3):e1000439. PMID: 19325886; PMCID: PMC2654960.
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  95. Liu JM, Livny J, Lawrence MS, Kimball MD, Waldor MK, Camilli A. Experimental discovery of sRNAs in Vibrio cholerae by direct cloning, 5S/tRNA depletion and parallel sequencing. Nucleic Acids Res. 2009 Apr; 37(6):e46. PMID: 19223322; PMCID: PMC2665243.
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  96. Ritchie JM, Waldor MK. Vibrio cholerae interactions with the gastrointestinal tract: lessons from animal studies. Curr Top Microbiol Immunol. 2009; 337:37-59. PMID: 19812979.
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  97. Waldor MK, Steinman L, Sriram S, Herzenberg L, Herzenberg L. Method of treating autoimmune diseases that are mediated by Leu3/CD4 phenotype T cells. 2009.
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  100. Vazquez-Juarez RC, Kuriakose JA, Rasko DA, Ritchie JM, Kendall MM, Slater TM, Sinha M, Luxon BA, Popov VL, Waldor MK, Sperandio V, Torres AG. CadA negatively regulates Escherichia coli O157:H7 adherence and intestinal colonization. Infect Immun. 2008 Nov; 76(11):5072-81. PMID: 18794292; PMCID: PMC2573373.
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  101. Livny J, Teonadi H, Livny M, Waldor MK. High-throughput, kingdom-wide prediction and annotation of bacterial non-coding RNAs. PLoS One. 2008 Sep 12; 3(9):e3197. PMID: 18787707; PMCID: PMC2527527.
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  102. Rasko DA, Moreira CG, Li de R, Reading NC, Ritchie JM, Waldor MK, Williams N, Taussig R, Wei S, Roth M, Hughes DT, Huntley JF, Fina MW, Falck JR, Sperandio V. Targeting QseC signaling and virulence for antibiotic development. Science. 2008 Aug 22; 321(5892):1078-80. PMID: 18719281; PMCID: PMC2605406.
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  103. Duigou S, Yamaichi Y, Waldor MK. ATP negatively regulates the initiator protein of Vibrio cholerae chromosome II replication. Proc Natl Acad Sci U S A. 2008 Jul 29; 105(30):10577-82. PMID: 18647828; PMCID: PMC2492486.
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  104. Shifrin Y, Peleg A, Ilan O, Nadler C, Kobi S, Baruch K, Yerushalmi G, Berdichevsky T, Altuvia S, Elgrably-Weiss M, Abe C, Knutton S, Sasakawa C, Ritchie JM, Waldor MK, Rosenshine I. Transient shielding of intimin and the type III secretion system of enterohemorrhagic and enteropathogenic Escherichia coli by a group 4 capsule. J Bacteriol. 2008 Jul; 190(14):5063-74. PMID: 18502854; PMCID: PMC2447026.
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  105. Osorio CR, Marrero J, Wozniak RA, Lemos ML, Burrus V, Waldor MK. Genomic and functional analysis of ICEPdaSpa1, a fish-pathogen-derived SXT-related integrating conjugative element that can mobilize a virulence plasmid. J Bacteriol. 2008 May; 190(9):3353-61. PMID: 18326579; PMCID: PMC2347376.
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  106. Ho TD, Davis BM, Ritchie JM, Waldor MK. Type 2 secretion promotes enterohemorrhagic Escherichia coli adherence and intestinal colonization. Infect Immun. 2008 May; 76(5):1858-65. PMID: 18316380; PMCID: PMC2346697.
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  107. Livny J, Waldor MK. Small non-coding RNAs in bacterial pathogenesis. Virulence Mechanisms of Bacterial Pathogen (Brogden, K. A., Minion, F. C., Stanton, T. B., Zhang, Q., Nolan, L. and Wannemuehler, M. J. editors). 2008; in press.
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  109. Ritchie JM, Brady MJ, Riley KN, Ho TD, Campellone KG, Herman IM, Donohue-Rolfe A, Tzipori S, Waldor MK, Leong JM. EspFU, a type III-translocated effector of actin assembly, fosters epithelial association and late-stage intestinal colonization by E. coli O157:H7. Cell Microbiol. 2008 Apr; 10(4):836-47. PMID: 18067584; PMCID: PMC2504705.
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  110. Murphy KC, Ritchie JM, Waldor MK, Løbner-Olesen A, Marinus MG. Dam methyltransferase is required for stable lysogeny of the Shiga toxin (Stx2)-encoding bacteriophage 933W of enterohemorrhagic Escherichia coli O157:H7. J Bacteriol. 2008 Jan; 190(1):438-41. PMID: 17981979; PMCID: PMC2223730.
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  111. Livny J, Yamaichi Y, Waldor MK. Distribution of centromere-like parS sites in bacteria: insights from comparative genomics. J Bacteriol. 2007 Dec; 189(23):8693-703. PMID: 17905987; PMCID: PMC2168934.
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  112. Davis BM, Waldor MK. RNase E-dependent processing stabilizes MicX, a Vibrio cholerae sRNA. Mol Microbiol. 2007 Jul; 65(2):373-85. PMID: 17590231; PMCID: PMC1976385.
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  113. Marrero J, Waldor MK. Determinants of entry exclusion within Eex and TraG are cytoplasmic. J Bacteriol. 2007 Sep; 189(17):6469-73. PMID: 17573467; PMCID: PMC1951900.
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  114. Yamaichi Y, Fogel MA, McLeod SM, Hui MP, Waldor MK. Distinct centromere-like parS sites on the two chromosomes of Vibrio spp. J Bacteriol. 2007 Jul; 189(14):5314-24. PMID: 17496089; PMCID: PMC1951861.
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  115. Livny J, Waldor MK. Identification of small RNAs in diverse bacterial species. Curr Opin Microbiol. 2007 Apr; 10(2):96-101. PMID: 17383222.
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  116. Waldor MK, Sperandio V. Adrenergic regulation of bacterial virulence. J Infect Dis. 2007 May 01; 195(9):1248-9. PMID: 17396992; PMCID: PMC2613639.
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  117. Marrero J, Waldor MK. The SXT/R391 family of integrative conjugative elements is composed of two exclusion groups. J Bacteriol. 2007 Apr; 189(8):3302-5. PMID: 17307849; PMCID: PMC1855829.
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  118. Yamaichi Y, Fogel MA, Waldor MK. par genes and the pathology of chromosome loss in Vibrio cholerae. Proc Natl Acad Sci U S A. 2007 Jan 09; 104(2):630-5. PMID: 17197419; PMCID: PMC1760642.
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  119. Mathur J, Davis BM, Waldor MK. Antimicrobial peptides activate the Vibrio cholerae sigmaE regulon through an OmpU-dependent signalling pathway. Mol Microbiol. 2007 Feb; 63(3):848-58. PMID: 17181782.
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  120. Ho TD, Waldor MK. Enterohemorrhagic Escherichia coli O157:H7 gal mutants are sensitive to bacteriophage P1 and defective in intestinal colonization. Infect Immun. 2007 Apr; 75(4):1661-6. PMID: 17158899; PMCID: PMC1865682.
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  121. Fogel MA, Waldor MK. A dynamic, mitotic-like mechanism for bacterial chromosome segregation. Genes Dev. 2006 Dec 01; 20(23):3269-82. PMID: 17158745; PMCID: PMC1686604.
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  122. Budde PP, Davis BM, Yuan J, Waldor MK. Characterization of a higBA toxin-antitoxin locus in Vibrio cholerae. J Bacteriol. 2007 Jan; 189(2):491-500. PMID: 17085558; PMCID: PMC1797405.
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  123. Slamti L, Livny J, Waldor MK. Global gene expression and phenotypic analysis of a Vibrio cholerae rpoH deletion mutant. J Bacteriol. 2007 Jan; 189(2):351-62. PMID: 17085549; PMCID: PMC1797412.
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  124. Quinones M, Kimsey HH, Ross W, Gourse RL, Waldor MK. LexA represses CTXphi transcription by blocking access of the alpha C-terminal domain of RNA polymerase to promoter DNA. J Biol Chem. 2006 Dec 22; 281(51):39407-12. PMID: 17046810.
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  125. Duigou S, Knudsen KG, Skovgaard O, Egan ES, Løbner-Olesen A, Waldor MK. Independent control of replication initiation of the two Vibrio cholerae chromosomes by DnaA and RctB. J Bacteriol. 2006 Sep; 188(17):6419-24. PMID: 16923911; PMCID: PMC1595377.
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  126. McLeod SM, Burrus V, Waldor MK. Requirement for Vibrio cholerae integration host factor in conjugative DNA transfer. J Bacteriol. 2006 Aug; 188(16):5704-11. PMID: 16885438; PMCID: PMC1540070.
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  127. Burrus V, Quezada-Calvillo R, Marrero J, Waldor MK. SXT-related integrating conjugative element in New World Vibrio cholerae. Appl Environ Microbiol. 2006 Apr; 72(4):3054-7. PMID: 16598018; PMCID: PMC1449008.
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  128. Burrus V, Marrero J, Waldor MK. The current ICE age: biology and evolution of SXT-related integrating conjugative elements. Plasmid. 2006 May; 55(3):173-83. PMID: 16530834.
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  129. Petridis M, Bagdasarian M, Waldor MK, Walker E. Horizontal transfer of Shiga toxin and antibiotic resistance genes among Escherichia coli strains in house fly (Diptera: Muscidae) gut. J Med Entomol. 2006 Mar; 43(2):288-95. PMID: 16619613.
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  131. Waldor MK. Disarming pathogens--a new approach for antibiotic development. N Engl J Med. 2006 Jan 19; 354(3):296-7. PMID: 16421373.
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  134. Livny J, Brencic A, Lory S, Waldor MK. Identification of 17 Pseudomonas aeruginosa sRNAs and prediction of sRNA-encoding genes in 10 diverse pathogens using the bioinformatic tool sRNAPredict2. Nucleic Acids Res. 2006; 34(12):3484-93. PMID: 16870723; PMCID: PMC1524904.
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  135. Egan ES, Duigou S, Waldor MK. Autorepression of RctB, an initiator of Vibrio cholerae chromosome II replication. J Bacteriol. 2006 Jan; 188(2):789-93. PMID: 16385068; PMCID: PMC1347293.
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  136. Waldor MK, Friedman DI. Phage regulatory circuits and virulence gene expression. Curr Opin Microbiol. 2005 Aug; 8(4):459-65. PMID: 15979389.
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  137. Livny J, Fogel MA, Davis BM, Waldor MK. sRNAPredict: an integrative computational approach to identify sRNAs in bacterial genomes. Nucleic Acids Res. 2005; 33(13):4096-105. PMID: 16049021; PMCID: PMC1180744.
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  138. McLeod SM, Kimsey HH, Davis BM, Waldor MK. CTXphi and Vibrio cholerae: exploring a newly recognized type of phage-host cell relationship. Mol Microbiol. 2005 Jul; 57(2):347-56. PMID: 15978069.
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  140. Marrero J, Waldor MK. Interactions between inner membrane proteins in donor and recipient cells limit conjugal DNA transfer. Dev Cell. 2005 Jun; 8(6):963-70. PMID: 15935784.
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  142. Ritchie JM, Waldor MK. The locus of enterocyte effacement-encoded effector proteins all promote enterohemorrhagic Escherichia coli pathogenicity in infant rabbits. Infect Immun. 2005 Mar; 73(3):1466-74. PMID: 15731044; PMCID: PMC1064977.
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  143. Quinones M, Kimsey HH, Waldor MK. LexA cleavage is required for CTX prophage induction. Mol Cell. 2005 Jan 21; 17(2):291-300. PMID: 15664197.
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  145. Fogel MA, Waldor MK. Distinct segregation dynamics of the two Vibrio cholerae chromosomes. Mol Microbiol. 2005 Jan; 55(1):125-36. PMID: 15612922.
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  148. McLeod SM, Waldor MK. Characterization of XerC- and XerD-dependent CTX phage integration in Vibrio cholerae. Mol Microbiol. 2004 Nov; 54(4):935-47. PMID: 15522078.
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  150. Egan ES, Løbner-Olesen A, Waldor MK. Synchronous replication initiation of the two Vibrio cholerae chromosomes. Curr Biol. 2004 Jul 13; 14(13):R501-2. PMID: 15242627.
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  151. Ding Y, Davis BM, Waldor MK. Hfq is essential for Vibrio cholerae virulence and downregulates sigma expression. Mol Microbiol. 2004 Jul; 53(1):345-54. PMID: 15225327.
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  152. Burrus V, Waldor MK. Shaping bacterial genomes with integrative and conjugative elements. Res Microbiol. 2004 Jun; 155(5):376-86. PMID: 15207870.
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  153. Mathur J, Waldor MK. The Vibrio cholerae ToxR-regulated porin OmpU confers resistance to antimicrobial peptides. Infect Immun. 2004 Jun; 72(6):3577-83. PMID: 15155667; PMCID: PMC415678.
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  155. Beaber JW, Hochhut B, Waldor MK. SOS response promotes horizontal dissemination of antibiotic resistance genes. Nature. 2004 Jan 01; 427(6969):72-4. PMID: 14688795.
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  156. Ritchie JM, Thorpe CM, Rogers AB, Waldor MK. Critical roles for stx2, eae, and tir in enterohemorrhagic Escherichia coli-induced diarrhea and intestinal inflammation in infant rabbits. Infect Immun. 2003 Dec; 71(12):7129-39. PMID: 14638803; PMCID: PMC308950.
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  157. Sumby P, Waldor MK. Transcription of the toxin genes present within the Staphylococcal phage phiSa3ms is intimately linked with the phage's life cycle. J Bacteriol. 2003 Dec; 185(23):6841-51. PMID: 14617648; PMCID: PMC262704.
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  158. Kimsey HH, Waldor MK. The CTXphi repressor RstR binds DNA cooperatively to form tetrameric repressor-operator complexes. J Biol Chem. 2004 Jan 23; 279(4):2640-7. PMID: 14610071.
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  160. Egan ES, Waldor MK. Distinct replication requirements for the two Vibrio cholerae chromosomes. Cell. 2003 Aug 22; 114(4):521-30. PMID: 12941279.
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  161. Ding Y, Waldor MK. Deletion of a Vibrio cholerae ClC channel results in acid sensitivity and enhanced intestinal colonization. Infect Immun. 2003 Jul; 71(7):4197-200. PMID: 12819118; PMCID: PMC161967.
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  162. Ritchie JM, Wagner PL, Acheson DW, Waldor MK. Comparison of Shiga toxin production by hemolytic-uremic syndrome-associated and bovine-associated Shiga toxin-producing Escherichia coli isolates. Appl Environ Microbiol. 2003 Feb; 69(2):1059-66. PMID: 12571029; PMCID: PMC143677.
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  163. Davis BM, Waldor MK. Filamentous phages linked to virulence of Vibrio cholerae. Curr Opin Microbiol. 2003 Feb; 6(1):35-42. PMID: 12615217.
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  164. Heilpern AJ, Waldor MK. pIIICTX, a predicted CTXphi minor coat protein, can expand the host range of coliphage fd to include Vibrio cholerae. J Bacteriol. 2003 Feb; 185(3):1037-44. PMID: 12533480; PMCID: PMC142820.
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  165. Beaber JW, Burrus V, Hochhut B, Waldor MK. Comparison of SXT and R391, two conjugative integrating elements: definition of a genetic backbone for the mobilization of resistance determinants. Cell Mol Life Sci. 2002 Dec; 59(12):2065-70. PMID: 12568332.
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  166. Davis BM, Kimsey HH, Kane AV, Waldor MK. A satellite phage-encoded antirepressor induces repressor aggregation and cholera toxin gene transfer. EMBO J. 2002 Aug 15; 21(16):4240-9. PMID: 12169626; PMCID: PMC126166.
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  167. Wagner PL, Waldor MK. Bacteriophage control of bacterial virulence. Infect Immun. 2002 Aug; 70(8):3985-93. PMID: 12117903; PMCID: PMC128183.
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  168. Beaber JW, Hochhut B, Waldor MK. Genomic and functional analyses of SXT, an integrating antibiotic resistance gene transfer element derived from Vibrio cholerae. J Bacteriol. 2002 Aug; 184(15):4259-69. PMID: 12107144; PMCID: PMC135215.
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  169. Huber KE, Waldor MK. Filamentous phage integration requires the host recombinases XerC and XerD. Nature. 2002 Jun 06; 417(6889):656-9. PMID: 12050668.
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  170. Boyd EF, Waldor MK. Evolutionary and functional analyses of variants of the toxin-coregulated pilus protein TcpA from toxigenic Vibrio cholerae non-O1/non-O139 serogroup isolates. Microbiology. 2002 Jun; 148(Pt 6):1655-66. PMID: 12055286.
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  171. Wagner PL, Livny J, Neely MN, Acheson DW, Friedman DI, Waldor MK. Bacteriophage control of Shiga toxin 1 production and release by Escherichia coli. Mol Microbiol. 2002 May; 44(4):957-70. PMID: 12010491.
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  172. 17 Waldor MK, Zychlinsky A. Host-pathogen interactions: bacteria. Microbes and their hosts: mutual interactions. Current Opinion in Microbiology. 2002; (5):17-19.
  173. Davis BD, Waldor MK. Mobile genetic elements and bacterial pathogenesis. Mobile DNAII (N. L. Craig et. al.eds.). 2002; 1040-59.
  174. Hochhut B, Lotfi Y, Mazel D, Faruque SM, Woodgate R, Waldor MK. Molecular analysis of antibiotic resistance gene clusters in vibrio cholerae O139 and O1 SXT constins. Antimicrob Agents Chemother. 2001 Nov; 45(11):2991-3000. PMID: 11600347; PMCID: PMC90773.
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  175. Moyer KE, Kimsey HH, Waldor MK. Evidence for a rolling-circle mechanism of phage DNA synthesis from both replicative and integrated forms of CTXphi. Mol Microbiol. 2001 Jul; 41(2):311-23. PMID: 11489120.
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  176. Wagner PL, Neely MN, Zhang X, Acheson DW, Waldor MK, Friedman DI. Role for a phage promoter in Shiga toxin 2 expression from a pathogenic Escherichia coli strain. J Bacteriol. 2001 Mar; 183(6):2081-5. PMID: 11222608; PMCID: PMC95105.
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  177. Wagner PL, Acheson DW, Waldor MK. Human neutrophils and their products induce Shiga toxin production by enterohemorrhagic Escherichia coli. Infect Immun. 2001 Mar; 69(3):1934-7. PMID: 11179378; PMCID: PMC98107.
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  178. Hochhut B, Beaber JW, Woodgate R, Waldor MK. Formation of chromosomal tandem arrays of the SXT element and R391, two conjugative chromosomally integrating elements that share an attachment site. J Bacteriol. 2001 Feb; 183(4):1124-32. PMID: 11157923; PMCID: PMC94984.
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  179. Keusch GT, Waldor MK. Cholera and other vibrioses. Harrison’s Principals of Internal Medicine 15th Edition (Braunwald E, Fauci AS, Kasper DL, Hauser SL, Longo DL, Jameson JL, eds.). 2001; 980-86.
  180. Davis BM, Moyer KE, Boyd EF, Waldor MK. CTX prophages in classical biotype Vibrio cholerae: functional phage genes but dysfunctional phage genomes. J Bacteriol. 2000 Dec; 182(24):6992-8. PMID: 11092860; PMCID: PMC94825.
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  181. Boyd EF, Heilpern AJ, Waldor MK. Molecular analyses of a putative CTXphi precursor and evidence for independent acquisition of distinct CTX(phi)s by toxigenic Vibrio cholerae. J Bacteriol. 2000 Oct; 182(19):5530-8. PMID: 10986258; PMCID: PMC110998.
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  182. Waldor MK, RayChaudhuri D. Treasure trove for cholera research. Nature. 2000 Aug 03; 406(6795):469-70. PMID: 10952295.
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  183. Faruque SM, Rahman MM, Waldor MK, Sack DA. Sunlight-induced propagation of the lysogenic phage encoding cholera toxin. Infect Immun. 2000 Aug; 68(8):4795-801. PMID: 10899892; PMCID: PMC98441.
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  184. Davis BM, Waldor MK. CTXphi contains a hybrid genome derived from tandemly integrated elements. Proc Natl Acad Sci U S A. 2000 Jul 18; 97(15):8572-7. PMID: 10880564; PMCID: PMC26989.
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  185. Cevallos AM, Zhang X, Waldor MK, Jaison S, Zhou X, Tzipori S, Neutra MR, Ward HD. Molecular cloning and expression of a gene encoding Cryptosporidium parvum glycoproteins gp40 and gp15. Infect Immun. 2000 Jul; 68(7):4108-16. PMID: 10858228; PMCID: PMC101706.
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  186. Davis BM, Lawson EH, Sandkvist M, Ali A, Sozhamannan S, Waldor MK. Convergence of the secretory pathways for cholera toxin and the filamentous phage, CTXphi. Science. 2000 Apr 14; 288(5464):333-5. PMID: 10764646.
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  187. Hochhut B, Marrero J, Waldor MK. Mobilization of plasmids and chromosomal DNA mediated by the SXT element, a constin found in Vibrio cholerae O139. J Bacteriol. 2000 Apr; 182(7):2043-7. PMID: 10715015; PMCID: PMC101929.
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  188. Heilpern AJ, Waldor MK. CTXphi infection of Vibrio cholerae requires the tolQRA gene products. J Bacteriol. 2000 Mar; 182(6):1739-47. PMID: 10692381; PMCID: PMC94473.
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  189. Boyd EF, Moyer KE, Shi L, Waldor MK. Infectious CTXPhi and the vibrio pathogenicity island prophage in Vibrio mimicus: evidence for recent horizontal transfer between V. mimicus and V. cholerae. Infect Immun. 2000 Mar; 68(3):1507-13. PMID: 10678967; PMCID: PMC97308.
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  190. Zhang X, McDaniel AD, Wolf LE, Keusch GT, Waldor MK, Acheson DW. Quinolone antibiotics induce Shiga toxin-encoding bacteriophages, toxin production, and death in mice. J Infect Dis. 2000 Feb; 181(2):664-70. PMID: 10669353.
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  191. Lee SH, Hava DL, Waldor MK, Camilli A. Regulation and temporal expression patterns of Vibrio cholerae virulence genes during infection. Cell. 1999 Dec 10; 99(6):625-34. PMID: 10612398.
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  192. Wagner PL, Acheson DW, Waldor MK. Isogenic lysogens of diverse shiga toxin 2-encoding bacteriophages produce markedly different amounts of shiga toxin. Infect Immun. 1999 Dec; 67(12):6710-4. PMID: 10569798; PMCID: PMC97090.
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  193. Davis BM, Kimsey HH, Chang W, Waldor MK. The Vibrio cholerae O139 Calcutta bacteriophage CTXphi is infectious and encodes a novel repressor. J Bacteriol. 1999 Nov; 181(21):6779-87. PMID: 10542181; PMCID: PMC94144.
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  194. Boyd EF, Waldor MK. Alternative mechanism of cholera toxin acquisition by Vibrio cholerae: generalized transduction of CTXPhi by bacteriophage CP-T1. Infect Immun. 1999 Nov; 67(11):5898-905. PMID: 10531246; PMCID: PMC96972.
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  195. Angelichio MJ, Spector J, Waldor MK, Camilli A. Vibrio cholerae intestinal population dynamics in the suckling mouse model of infection. Infect Immun. 1999 Aug; 67(8):3733-9. PMID: 10417131; PMCID: PMC96647.
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  196. Hochhut B, Waldor MK. Site-specific integration of the conjugal Vibrio cholerae SXT element into prfC. Mol Microbiol. 1999 Apr; 32(1):99-110. PMID: 10216863.
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  197. Hochhut B, Waldor MK. Transfer of antibiotic resistance genes in Vibrio cholerae by a novel genetic element. Proceedings of the U.S.-Korea Forum on Emerging Infectious Diseases. 1999; 118-25.
  198. Meno Y, Waldor MK, Mekalanos JJ, Amako K. Morphological and physical characterization of the capsular layer of Vibrio cholerae O139. Arch Microbiol. 1998 Oct; 170(5):339-44. PMID: 9818353.
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  199. Acheson DW, Reidl J, Zhang X, Keusch GT, Mekalanos JJ, Waldor MK. In vivo transduction with shiga toxin 1-encoding phage. Infect Immun. 1998 Sep; 66(9):4496-8. PMID: 9712806; PMCID: PMC108544.
    View in: PubMed, PubMed Central
  200. Kimsey HH, Waldor MK. Vibrio cholerae hemagglutinin/protease inactivates CTXphi. Infect Immun. 1998 Sep; 66(9):4025-9. PMID: 9712742; PMCID: PMC108480.
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  201. Kimsey HH, Nair GB, Ghosh A, Waldor MK. Diverse CTXphis and evolution of new pathogenic Vibrio cholerae. Lancet. 1998 Aug 08; 352(9126):457-8. PMID: 9708764.
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  202. Waldor MK. Bacteriophage biology and bacterial virulence. Trends Microbiol. 1998 Aug; 6(8):295-7. PMID: 9746936.
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  203. Kimsey HH, Waldor MK. CTXphi immunity: application in the development of cholera vaccines. Proc Natl Acad Sci U S A. 1998 Jun 09; 95(12):7035-9. PMID: 9618534; PMCID: PMC22729.
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  204. Rubin EJ, Lin W, Mekalanos JJ, Waldor MK. Replication and integration of a Vibrio cholerae cryptic plasmid linked to the CTX prophage. Mol Microbiol. 1998 Jun; 28(6):1247-54. PMID: 9680213.
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  205. Calia KE, Waldor MK, Calderwood SB. Use of representational difference analysis to identify genomic differences between pathogenic strains of Vibrio cholerae. Infect Immun. 1998 Feb; 66(2):849-52. PMID: 9453654; PMCID: PMC107982.
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  206. Waldor MK, Lazar S, Kimsey H, Williams J, Mekalanos JJ. CTXφ: A Novel Filamentous Phage Encoding Cholera Toxin. Bacterial Protein Toxins Zent.bl. Bakteriol. Suppl. 29 (J. Hacker et al, eds.). 1998; 363-71.
  207. Lazar S, Waldor MK. ToxR-independent expression of cholera toxin from the replicative form of CTXphi. Infect Immun. 1998 Jan; 66(1):394-7. PMID: 9423889; PMCID: PMC107917.
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  208. Rubin EJ, Waldor MK, Mekalanos JJ. Mobile genetic elements and the evolution of new epidemic strains of Vibrio cholerae. Emerging Infections (R. M. Krause, ed.). 1998; 147-61.
  209. Mekalanos JJ, Rubin EJ, Waldor MK. Cholera: molecular basis for emergence and pathogenesis. FEMS Immunol Med Microbiol. 1997 Aug; 18(4):241-8. PMID: 9348159.
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  210. Waldor MK, Rubin EJ, Pearson GD, Kimsey H, Mekalanos JJ. Regulation, replication, and integration functions of the Vibrio cholerae CTXphi are encoded by region RS2. Mol Microbiol. 1997 Jun; 24(5):917-26. PMID: 9220000.
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  211. Waldor MK, Tschäpe H, Mekalanos JJ. A new type of conjugative transposon encodes resistance to sulfamethoxazole, trimethoprim, and streptomycin in Vibrio cholerae O139. J Bacteriol. 1996 Jul; 178(14):4157-65. PMID: 8763944; PMCID: PMC178173.
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  212. Waldor MK, Mekalanos JJ. Lysogenic conversion by a filamentous phage encoding cholera toxin. Science. 1996 Jun 28; 272(5270):1910-4. PMID: 8658163.
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  213. Waldor MK, Mekalanos JJ. Progress toward safe oral live-attenuated cholera vaccines. Mucosal Vaccines (H. Kiyono, P. Ogra, and J. McGhee, eds.). 1996; 229-38.
  214. Waldor MK, Mekalanos JJ. . Vibrio cholerae: molecular pathogenesis, immune response, and vaccine development. Enteric Infections and Immune Responses (H. Friedman, L. Paradise and M. Bendinelli, eds.). 1996; 37-56.
  215. Mekalanos JJ, Waldor MK, Gardel CL, Killeen KP, Beattie DT, Adams JM, Hyman T, Spriggs DR, Coster TS, Kenner JR, Trofa A, Taylor D, Sadoff JC. . Construction and characterization of live, attenuated Vibrio cholerae El Tor O1 and O139 vaccines. Vaccines 96: Molecular approaches to the control of infectious diseases (F. Brown, E. Norrby, D. Burton, and J. Mekalanos, eds.). 1996; 103-9.
  216. Coster TS, Killeen KP, Waldor MK, Beattie DT, Spriggs DR, Kenner JR, Trofa A, Sadoff JC, Mekalanos JJ, Taylor DN. Safety, immunogenicity, and efficacy of live attenuated Vibrio cholerae O139 vaccine prototype. Lancet. 1995 Apr 15; 345(8955):949-52. PMID: 7715293.
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  217. Mekalanos JJ, Waldor MK, Gardel CL, Coster TS, Kenner J, Killeen K, Beattie D, Trofa A, Taylor D, Sadoff JC. . Live cholera vaccines: perspectives on their construction and safety. 1995; 93:255-62.
  218. Waldor MK, Colwell R, Mekalanos JJ. The Vibrio cholerae O139 serogroup antigen includes an O-antigen capsule and lipopolysaccharide virulence determinants. Proc Natl Acad Sci U S A. 1994 Nov 22; 91(24):11388-92. PMID: 7972070; PMCID: PMC45236.
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  219. Waldor MK, Mekalanos JJ. Emergence of a new cholera pandemic: molecular analysis of virulence determinants in Vibrio cholerae O139 and development of a live vaccine prototype. J Infect Dis. 1994 Aug; 170(2):278-83. PMID: 8035010.
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  220. Waldor MK, Mekalanos JJ. Vibrio cholerae O139 specific gene sequences. Lancet. 1994 May 28; 343(8909):1366. PMID: 7910357.
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  221. Waldor MK, Mekalanos JJ. ToxR regulates virulence gene expression in non-O1 strains of Vibrio cholerae that cause epidemic cholera. Infect Immun. 1994 Jan; 62(1):72-8. PMID: 7903285; PMCID: PMC186069.
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  222. Mahan MJ, Slauch JM, Hanna PC, Camilli AC, Tobias JW, Waldor MK, Mekalanos JJ. Selection for bacterial virulence genes that are specifically induced in host tissues: The hunt for virulence factors. Infectious Agents and Diseases Volume II (Falkow S ed.). 1994; 2:263-8.
  223. Mahan MJ, Slauch JM, Hanna PC, Camilli A, Tobias JW, Waldor MK, Mekalanos JJ. Selection for bacterial genes that are specifically induced in host tissues: the hunt for virulence factors. Infect Agents Dis. 1993 Aug; 2(4):263-8. PMID: 8173806.
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  224. Waldor MK, Mekalanos JJ. Molecular analysis of virulence determinants carried by the Bengal strains of Vibrio cholerae O139 and construction of live vaccine prototypes. 29th Joint conference on cholera and related diarrheal diseases; U. S. - Japan Cooperative Medical Science Program. 1993; 42-6.
  225. Waldor MK, Wilson B, Swartz M. Cellulitis caused by Legionella pneumophila. Clin Infect Dis. 1993 Jan; 16(1):51-3. PMID: 8448318.
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  226. Waldor M, Roberts D, Kazanjian P. In utero infection due to Pasteurella multocida in the first trimester of pregnancy: case report and review. Clin Infect Dis. 1992 Feb; 14(2):497-500. PMID: 1554837.
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  227. Waldor MK. Treatment of autoimmune disease with monoclonal anti-CD4 antibodies. Immunol Ser. 1989; 45:573-86. PMID: 2577329.
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  228. Waldor MK. Treatment of autoimmune disease with monoclonal anti-CD4 antibodies. Cell Surface Antigen Thy-1: Immunology, Neurology and Therapeutic Applications (A. Reif, M Schlesinger, eds.). 1989; 573-86.
  229. Acha-Orbea H, Mitchell DJ, Timmermann L, Wraith DC, Tausch GS, Waldor MK, Zamvil SS, McDevitt HO, Steinman L. Limited heterogeneity of T cell receptors from lymphocytes mediating autoimmune encephalomyelitis allows specific immune intervention. Cell. 1988 Jul 15; 54(2):263-73. PMID: 2455603.
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  230. Zamvil SS, Mitchell DJ, Lee NE, Moore AC, Waldor MK, Sakai K, Rothbard JB, McDevitt HO, Steinman L, Acha-Orbea H. Predominant expression of a T cell receptor V beta gene subfamily in autoimmune encephalomyelitis. J Exp Med. 1988 May 01; 167(5):1586-96. PMID: 2452856; PMCID: PMC2188936.
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  231. Waldor MK, Mitchell D, Kipps TJ, Herzenberg LA, Steinman L. Importance of immunoglobulin isotype in therapy of experimental autoimmune encephalomyelitis with monoclonal anti-CD4 antibody. J Immunol. 1987 Dec 01; 139(11):3660-4. PMID: 3500226.
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  232. Vollmer TL, Waldor MK, Steinman L, Conley FK. Depletion of T-4+ lymphocytes with monoclonal antibody reactivates toxoplasmosis in the central nervous system: a model of superinfection in AIDS. J Immunol. 1987 Jun 01; 138(11):3737-41. PMID: 3108372.
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  233. Waldor MK, O'Hearn M, Sriram S, Steinman L. Treatment of experimental autoimmune myasthenia gravis with monoclonal antibodies to immune response gene products. Ann N Y Acad Sci. 1987; 505:655-68. PMID: 2961299.
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  234. Steinman L, Zamvil S, O'Hearn M, Sriram S, Mitchell D, Waldor MK. Experiences with anti-Ia therapy in the mouse the monkey and applications to human protocols. Anti-Ia Antibodies in the Treatment of Autoimmune Disease (J. Broche, J. Clot, and J. Sany, eds.). 1986; 109-28.
  235. Steinman L, Waldor MK, Zamvil SS, Lim M, Herzenberg L, Herzenberg L, McDevitt HO, Mitchell D, Sriram S. Therapy of autoimmune diseases with antibody to immune response gene products or to T-cell surface markers. Ann N Y Acad Sci. 1986; 475:274-84. PMID: 3098154.
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  236. Waldor MK, Sriram S, Hardy R, Herzenberg LA, Herzenberg LA, Lanier L, Lim M, Steinman L. Reversal of experimental allergic encephalomyelitis with monoclonal antibody to a T-cell subset marker. Science. 1985 Jan 25; 227(4685):415-7. PMID: 3155574.
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  237. Steinman L, Trotter J, Waldor M, Sriram S. . New approaches to therapy of autoimmune disease. Concepts in Immunopathology (J. Cruse and R. Lewis, eds.). 1985; 1:85-95.
  238. Steinman L, Trotter J, Waldor M, Sriram S. New approaches to therapy of autoimmune disease. Concepts Immunopathol. 1985; 1:85-95. PMID: 3879936.
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  239. Waldor MK, Hardy RR, Hayakawa K, Steinman L, Herzenberg LA, Herzenberg LA. Disappearance and reappearance of B cells after in vivo treatment with monoclonal anti-I-A antibodies. Proc Natl Acad Sci U S A. 1984 May; 81(9):2855-8. PMID: 6609367; PMCID: PMC345170.
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  240. Steinman L, Schwartz G, Waldor M, O'Hearn M, Lim M, Sriram S. Gene specific and antigen specific strategies for the induction of suppressor T cells to myelin basic protein. Prog Clin Biol Res. 1984; 146:393-7. PMID: 6201908.
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  241. Steinman L, Schwartz G, Waldor M, O'Hearn M, Lim M, Sriram S. Gene specific and antigen specific strategies for the induction of suppressor T cells to myelin basic protein. Experimental Allergic Encephalomyelitis: A Useful Model for Multiple Sclerosis. (E. Alvord, M. Kies, A. Suckling, eds.). 1984; 393-97.
  242. Waldor MK, Sriram S, McDevitt HO, Steinman L. In vivo therapy with monoclonal anti-I-A antibody suppresses immune responses to acetylcholine receptor. Proc Natl Acad Sci U S A. 1983 May; 80(9):2713-7. PMID: 6405386; PMCID: PMC393898.
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