Harvard Catalyst Profiles

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Robert Brown, M.D.,C.M.

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Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01NS088689 (BROWN, ROBERT H) Jul 1, 2014 - Apr 30, 2018
    NIH/NINDS
    Silencing C9or72 with rAAV Mediated RNAi
    Role: Principal Investigator
  2. R01NS079836 (BROWN, ROBERT H) Jul 1, 2012 - Apr 30, 2016
    NIH/NINDS
    High Throughput Screening for Compounds to Mitigate Toxicity of FUS/TLS &SOD1
    Role: Principal Investigator
  3. RC2NS070342 (BROWN, ROBERT H) Sep 30, 2009 - Aug 31, 2013
    NIH/NINDS
    Full Human Genome Sequencing in ALS
    Role: Principal Investigator
  4. RC1NS068391 (BROWN, ROBERT H) Sep 30, 2009 - Aug 31, 2011
    NIH/NINDS
    Transgenic Mouse Models of FUS/TLS-Mediated Amyotrophic Lateral Sclerosis
    Role: Principal Investigator
  5. U01NS052225 (BROWN, ROBERT H) Sep 1, 2007 - Aug 31, 2012
    NIH/NINDS
    Development of New Therapeutics for Amyotrophic Lateral Sclerosis
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Brown RH. Pulmonary Hypertension and the Quantification of Lung Density on Chest CT: "I Know It When I See It.". Acad Radiol. 2016 08; 23(8):933-4. PMID: 27298057.
    Citations:    Fields:    Translation:Humans
  2. Weiss MD, Macklin EA, Simmons Z, Knox AS, Greenblatt DJ, Atassi N, Graves M, Parziale N, Salameh JS, Quinn C, Brown RH, Distad JB, Trivedi J, Shefner JM, Barohn RJ, Pestronk A, Swenson A, Cudkowicz ME. A randomized trial of mexiletine in ALS: Safety and effects on muscle cramps and progression. Neurology. 2016 Apr 19; 86(16):1474-81. PMID: 26911633.
    Citations: 6     Fields:    Translation:HumansCTClinical Trials
  3. Fridman V, Oaklander AL, David WS, Johnson EA, Pan J, Novak P, Brown RH, Eichler FS. Natural history and biomarkers in hereditary sensory neuropathy type 1. Muscle Nerve. 2015 Apr; 51(4):489-95. PMID: 25042817.
    Citations: 4     Fields:    Translation:Humans
  4. Brown RH. Groundhog day: airway narrowing, deep inspirations, and asthma. Am J Respir Crit Care Med. 2014 Oct 15; 190(8):847-8. PMID: 25317460.
    Citations: 1     Fields:    Translation:Humans
  5. Wainger BJ, Kiskinis E, Mellin C, Wiskow O, Han SS, Sandoe J, Perez NP, Williams LA, Lee S, Boulting G, Berry JD, Brown RH, Cudkowicz ME, Bean BP, Eggan K, Woolf CJ. Intrinsic membrane hyperexcitability of amyotrophic lateral sclerosis patient-derived motor neurons. Cell Rep. 2014 Apr 10; 7(1):1-11. PMID: 24703839.
    Citations: 118     Fields:    Translation:HumansCells
  6. Brown RH, Brooker A, Wise RA, Reynolds C, Loccioni C, Russo A, Risby TH. Forced expiratory capnography and chronic obstructive pulmonary disease (COPD). J Breath Res. 2013 Mar; 7(1):017108. PMID: 23445906.
    Citations: 1     Fields:    Translation:Humans
  7. Krodel DJ, Bittner EA, Abdulnour RE, Brown RH, Eikermann M. Negative pressure pulmonary edema following bronchospasm. Chest. 2011 Nov; 140(5):1351-1354. PMID: 22045880.
    Citations: 4     Fields:    Translation:Humans
  8. Ozdinler PH, Benn S, Yamamoto TH, Güzel M, Brown RH, Macklis JD. Corticospinal motor neurons and related subcerebral projection neurons undergo early and specific neurodegeneration in hSOD1G?³A transgenic ALS mice. J Neurosci. 2011 Mar 16; 31(11):4166-77. PMID: 21411657.
    Citations: 55     Fields:    Translation:AnimalsCells
  9. Eberlein M, Permutt S, Brown RH, Brooker A, Chahla MF, Bolukbas S, Nathan SD, Pearse DB, Orens JB, Brower RG. Supranormal expiratory airflow after bilateral lung transplantation is associated with improved survival. Am J Respir Crit Care Med. 2011 Jan 01; 183(1):79-87. PMID: 20693376.
    Citations: 12     Fields:    Translation:Humans
  10. Eichler FS, Hornemann T, McCampbell A, Kuljis D, Penno A, Vardeh D, Tamrazian E, Garofalo K, Lee HJ, Kini L, Selig M, Frosch M, Gable K, von Eckardstein A, Woolf CJ, Guan G, Harmon JM, Dunn TM, Brown RH. Overexpression of the wild-type SPT1 subunit lowers desoxysphingolipid levels and rescues the phenotype of HSAN1. J Neurosci. 2009 Nov 18; 29(46):14646-51. PMID: 19923297.
    Citations: 30     Fields:    Translation:Animals
  11. Brown RH, Risby TH. Changes in oxidative stress during outpatient surgery. J Breath Res. 2009 Mar; 3(1):016002. PMID: 21383450.
    Citations: 1     Fields:    
  12. Brown RH, Wagner EM, Cope KA, Risby TH. Propofol and in vivo oxidative stress: effects of preservative. J Breath Res. 2009 Mar; 3(1):016003. PMID: 21383451.
    Citations: 1     Fields:    
  13. Qureshi M, Shui A, Dibernardo AB, Brown RH, Schoenfeld DA, Cudkowicz ME. Medications and laboratory parameters as prognostic factors in amyotrophic lateral sclerosis. Amyotroph Lateral Scler. 2008 Dec; 9(6):369-74. PMID: 18608098.
    Citations: 5     Fields:    Translation:Humans
  14. Qureshi M, Brown RH, Rogers JT, Cudkowicz ME. Serum ferritin and metal levels as risk factors for amyotrophic lateral sclerosis. Open Neurol J. 2008 Sep 12; 2:51-4. PMID: 19452011.
    Citations: 11     
  15. Ay I, Francis JW, Brown RH. VEGF increases blood-brain barrier permeability to Evans blue dye and tetanus toxin fragment C but not adeno-associated virus in ALS mice. Brain Res. 2008 Oct 09; 1234:198-205. PMID: 18725212.
    Citations: 20     Fields:    Translation:AnimalsCells
  16. Mills C, Makwana M, Wallace A, Benn S, Schmidt H, Tegeder I, Costigan M, Brown RH, Raivich G, Woolf CJ. Ro5-4864 promotes neonatal motor neuron survival and nerve regeneration in adult rats. Eur J Neurosci. 2008 Feb; 27(4):937-46. PMID: 18333964.
    Citations: 14     Fields:    Translation:HumansAnimalsCells
  17. Hoag JB, Fuld M, Brown RH, Simon BA. Recirculation of inhaled xenon does not alter lung CT density. Acad Radiol. 2007 Jan; 14(1):81-4. PMID: 17178369.
    Citations: 3     Fields:    Translation:Animals
  18. Brown R, DiMarco AF, Hoit JD, Garshick E. Respiratory dysfunction and management in spinal cord injury. Respir Care. 2006 Aug; 51(8):853-68;discussion 869-70. PMID: 16867197.
    Citations: 61     Fields:    Translation:Humans
  19. McCampbell A, Truong D, Broom DC, Allchorne A, Gable K, Cutler RG, Mattson MP, Woolf CJ, Frosch MP, Harmon JM, Dunn TM, Brown RH. Mutant SPTLC1 dominantly inhibits serine palmitoyltransferase activity in vivo and confers an age-dependent neuropathy. Hum Mol Genet. 2005 Nov 15; 14(22):3507-21. PMID: 16210380.
    Citations: 25     Fields:    Translation:AnimalsCells
  20. Lecamwasam HS, Hess D, Brown R, Kwolek CJ, Bigatello LM. Diaphragmatic paralysis after endovascular stent grafting of a thoracoabdominal aortic aneurysm. Anesthesiology. 2005 Mar; 102(3):690-2. PMID: 15731612.
    Citations:    Fields:    Translation:Humans
  21. Zeitzer JM, Ayas NT, Wu AD, Czeisler CA, Brown R. Bilateral oculosympathetic paresis associated with loss of nocturnal melatonin secretion in patients with spinal cord injury. J Spinal Cord Med. 2005; 28(1):55-9. PMID: 15832904.
    Citations: 7     Fields:    Translation:Humans
  22. Pasinelli P, Belford ME, Lennon N, Bacskai BJ, Hyman BT, Trotti D, Brown RH. Amyotrophic lateral sclerosis-associated SOD1 mutant proteins bind and aggregate with Bcl-2 in spinal cord mitochondria. Neuron. 2004 Jul 08; 43(1):19-30. PMID: 15233914.
    Citations: 126     Fields:    Translation:HumansAnimalsCells
  23. Zhu S, Li M, Figueroa BE, Liu A, Stavrovskaya IG, Pasinelli P, Beal MF, Brown RH, Kristal BS, Ferrante RJ, Friedlander RM. Prophylactic creatine administration mediates neuroprotection in cerebral ischemia in mice. J Neurosci. 2004 Jun 30; 24(26):5909-12. PMID: 15229238.
    Citations: 23     Fields:    Translation:AnimalsCells
  24. Ray SS, Nowak RJ, Strokovich K, Brown RH, Walz T, Lansbury PT. An intersubunit disulfide bond prevents in vitro aggregation of a superoxide dismutase-1 mutant linked to familial amytrophic lateral sclerosis. Biochemistry. 2004 May 04; 43(17):4899-905. PMID: 15109247.
    Citations: 38     Fields:    Translation:HumansCells
  25. Maxwell MM, Pasinelli P, Kazantsev AG, Brown RH. RNA interference-mediated silencing of mutant superoxide dismutase rescues cyclosporin A-induced death in cultured neuroblastoma cells. Proc Natl Acad Sci U S A. 2004 Mar 02; 101(9):3178-83. PMID: 14981234.
    Citations: 22     Fields:    Translation:HumansCells
  26. Dangond F, Hwang D, Camelo S, Pasinelli P, Frosch MP, Stephanopoulos G, Stephanopoulos G, Brown RH, Gullans SR. Molecular signature of late-stage human ALS revealed by expression profiling of postmortem spinal cord gray matter. Physiol Genomics. 2004 Jan 15; 16(2):229-39. PMID: 14645737.
    Citations: 40     Fields:    Translation:HumansCells
  27. Garrison A, Clifford K, Gleason SF, Tun CG, Brown R, Garshick E. Alcohol use associated with cervical spinal cord injury. J Spinal Cord Med. 2004; 27(2):111-5. PMID: 15162880.
    Citations: 3     Fields:    Translation:Humans
  28. Hoit JD, Banzett RB, Lohmeier HL, Hixon TJ, Brown R. Clinical ventilator adjustments that improve speech. Chest. 2003 Oct; 124(4):1512-21. PMID: 14555587.
    Citations: 6     Fields:    Translation:Humans
  29. Kelley A, Garshick E, Gross ER, Lieberman SL, Tun CG, Brown R. Spirometry testing standards in spinal cord injury. Chest. 2003 Mar; 123(3):725-30. PMID: 12628869.
    Citations: 20     Fields:    Translation:Humans
  30. King LS, Nielsen S, Agre P, Brown RH. Decreased pulmonary vascular permeability in aquaporin-1-null humans. Proc Natl Acad Sci U S A. 2002 Jan 22; 99(2):1059-63. PMID: 11773634.
    Citations: 23     Fields:    Translation:Humans
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Funded by the NIH/NCATS Clinical and Translational Science Award (CTSA) program, grant number UL1TR001102, and through institutional support from Harvard University, Harvard Medical School, Harvard T.H. Chan School of Public Health, Beth Israel Deaconess Medical Center, Boston Children's Hospital, Brigham and Women's Hospital, Massachusetts General Hospital and the Dana Farber Cancer Institute.