Harvard Catalyst Profiles

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Juan Carlos Varela, Ph.D., M.D.

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Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Mori S, Guo M, Rivera-Robles N, Edgar CM, Mcvey CP, Yi F, Ahmad S, Patel RD, Varela JC. Evaluation of different pharmacokinetically guided IV busulfan exposure ranges on adult patient outcomes after hematopoietic stem cell transplantation. Ann Hematol. 2023 Jan; 102(1):181-190. PMID: 36462061.
    Citations:    Fields:    Translation:Humans
  2. Guo M, Liu J, Clark P, Ahmad S, Patel R, Varela JC, Mori S. Cryopreserved versus fresh peripheral blood allogeneic stem cell transplantation outcomes in patients receiving post-transplant cyclophosphamide for graft-versus-host prophylaxis during the COVID-19 pandemic: a single center experience. Int J Hematol. 2023 Mar; 117(3):428-437. PMID: 36378406; PMCID: PMC9664429.
    Citations:    Fields:    
  3. Yu J, Du Y, Jalil A, Ahmed Z, Mori S, Patel R, Varela JC, Chang CC. Mutational profiling of myeloid neoplasms associated genes may aid the diagnosis of acute myeloid leukemia with myelodysplasia-related changes. Leuk Res. 2021 11; 110:106701. PMID: 34481124.
    Citations: 1     Fields:    Translation:Humans
  4. Yu J, Sun J, Du Y, Patel R, Varela JC, Mori S, Chang CC. Adverse Impact of DNA Methylation Regulatory Gene Mutations on the Prognosis of AML Patients in the 2017 ELN Favorable Risk Group, Particularly Those Defined by NPM1 Mutation. Diagnostics (Basel). 2021 May 29; 11(6). PMID: 34072516; PMCID: PMC8227437.
    Citations:    
  5. Yu J, Du Y, Ahmad S, Patel RD, Varela JC, Chang CC, Mori S. Comparison of Myeloablative versus Reduced-Intensity Conditioning Regimens in Allogeneic Stem Cell Transplantation Recipients with Acute Myelogenous Leukemia with Measurable Residual Disease-Negative Disease at the Time of Transplantation: A Retrospective Cohort Study. Transplant Cell Ther. 2021 08; 27(8):663.e1-663.e6. PMID: 33951497.
    Citations:    Fields:    Translation:Humans
  6. Yu J, Diaz JD, Goldstein SC, Patel RD, Varela JC, Reyenga C, Smith M, Smith T, Balls J, Ahmad S, Mori S. Impact of Next-Generation Sequencing Cell-free Pathogen DNA Test on Antimicrobial Management in Adults with Hematological Malignancies and Transplant Recipients with Suspected Infections. Transplant Cell Ther. 2021 06; 27(6):500.e1-500.e6. PMID: 33849818.
    Citations: 1     Fields:    Translation:Humans
  7. Ali N, Tomlinson B, Metheny L, Goldstein SC, Fu P, Cao S, Caimi P, Patel RD, Varela JC, Andrade L, Balls JW, Baer L, Smith M, Smith T, Nelson M, de Lima M, Mori S. Conditioning regimen intensity and low-dose azacitidine maintenance after allogeneic hematopoietic cell transplantation for acute myeloid leukemia. Leuk Lymphoma. 2020 12; 61(12):2839-2849. PMID: 32650686.
    Citations: 10     Fields:    Translation:Humans
  8. Nguyen H, Alawieh A, Bastian D, Kuril S, Dai M, Daenthanasanmak A, Zhang M, Iamsawat S, Schutt SD, Wu Y, Sleiman MM, Shetty A, Atkinson C, Sun S, Varela JC, Tomlinson S, Yu XZ. Targeting the Complement Alternative Pathway Permits Graft Versus Leukemia Activity while Preventing Graft Versus Host Disease. Clin Cancer Res. 2020 07 01; 26(13):3481-3490. PMID: 31919135; PMCID: PMC7334060.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  9. Yuan C, Boyd AM, Nelson J, Patel RD, Varela JC, Goldstein SC, Ahmad S, Zhu X, Mori S. Eltrombopag for Treating Thrombocytopenia after Allogeneic Stem Cell Transplantation. Biol Blood Marrow Transplant. 2019 07; 25(7):1320-1324. PMID: 30710685.
    Citations: 16     Fields:    Translation:HumansCTClinical Trials
  10. Wang RC, Mori S, Zhu X, Varela JC, Dickman D, Patel R, Ward D, Goldstein SC, Chang CC. Increased bone marrow CD56bright natural killer cells at 30 days after allogeneic stem cell transplantation associated with adverse patient outcome. Bone Marrow Transplant. 2019 06; 54(6):924-927. PMID: 30563982.
    Citations:    Fields:    Translation:HumansCells
  11. Mori S, Patel RD, Ahmad S, Varela J, Smith T, Altoos R, Shen Q, Goldstein SC, Persky DO. Aggressive Leukemic Non-Nodal Mantle Cell Lymphoma With P53 Gene Rearrangement/Mutation is Highly Responsive to Rituximab/Ibrutinib Combination Therapy. Clin Lymphoma Myeloma Leuk. 2019 02; 19(2):e93-e97. PMID: 30559058.
    Citations: 1     Fields:    Translation:Humans
  12. Schütz C, Varela JC, Perica K, Haupt C, Oelke M, Schneck JP. Correction: Antigen-specific T cell Redirectors: a nanoparticle based approach for redirecting T cells. Oncotarget. 2018 08 17; 9(64):32401. PMID: 30190796; PMCID: PMC6122358.
    Citations:    Fields:    
  13. Neal LR, Bailey SR, Wyatt MM, Bowers JS, Majchrzak K, Nelson MH, Haupt C, Paulos CM, Varela JC. The Basics of Artificial Antigen Presenting Cells in T Cell-Based Cancer Immunotherapies. J Immunol Res Ther. 2017; 2(1):68-79. PMID: 28825053; PMCID: PMC5560309.
    Citations: 25     
  14. Majchrzak K, Nelson MH, Bowers JS, Bailey SR, Wyatt MM, Wrangle JM, Rubinstein MP, Varela JC, Li Z, Himes RA, Chan SS, Paulos CM. ß-catenin and PI3Kd inhibition expands precursor Th17 cells with heightened stemness and antitumor activity. JCI Insight. 2017 Apr 20; 2(8). PMID: 28422756; PMCID: PMC5396523.
    Citations: 20     Fields:    
  15. Schütz C, Varela JC, Perica K, Haupt C, Oelke M, Schneck JP. Antigen-specific T cell Redirectors: a nanoparticle based approach for redirecting T cells. Oncotarget. 2016 Oct 18; 7(42):68503-68512. PMID: 27602488; PMCID: PMC5356569.
    Citations: 14     Fields:    Translation:HumansAnimalsCells
  16. Perica K, Bieler JG, Schütz C, Varela JC, Douglass J, Skora A, Chiu YL, Oelke M, Kinzler K, Zhou S, Vogelstein B, Schneck JP. Enrichment and Expansion with Nanoscale Artificial Antigen Presenting Cells for Adoptive Immunotherapy. ACS Nano. 2015 Jul 28; 9(7):6861-71. PMID: 26171764; PMCID: PMC5082131.
    Citations: 51     Fields:    Translation:HumansAnimalsCells
  17. Varela JC, Tomlinson S. Complement: an overview for the clinician. Hematol Oncol Clin North Am. 2015 Jun; 29(3):409-27. PMID: 26043382; PMCID: PMC4456616.
    Citations: 22     Fields:    Translation:Humans
  18. Perica K, Varela JC, Oelke M, Schneck J. Adoptive T cell immunotherapy for cancer. Rambam Maimonides Med J. 2015 Jan; 6(1):e0004. PMID: 25717386; PMCID: PMC4327320.
    Citations: 81     
  19. Bruns H, Bessell C, Varela JC, Haupt C, Fang J, Pasemann S, Mackensen A, Oelke M, Schneck JP, Schütz C. CD47 Enhances In Vivo Functionality of Artificial Antigen-Presenting Cells. Clin Cancer Res. 2015 May 01; 21(9):2075-83. PMID: 25593301; PMCID: PMC4417460.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  20. DeZern AE, Uknis M, Yuan X, Mukhina GL, Varela J, Saye J, Pu J, Brodsky RA. Complement blockade with a C1 esterase inhibitor in paroxysmal nocturnal hemoglobinuria. Exp Hematol. 2014 Oct; 42(10):857-61.e1. PMID: 25034232; PMCID: PMC4250431.
    Citations: 8     Fields:    Translation:HumansCells
  21. Varela JC, Velo M, Espinar E, Llamas JM, Rúperez E, Manero JM, Javier Gil F. Mechanical properties of a new thermoplastic polymer orthodontic archwire. Mater Sci Eng C Mater Biol Appl. 2014 Sep; 42:1-6. PMID: 25063084.
    Citations: 2     Fields:    
  22. Varela JC, Brodsky RA. Paroxysmal nocturnal hemoglobinuria and the age of therapeutic complement inhibition. Expert Rev Clin Immunol. 2013 Nov; 9(11):1113-24. PMID: 24168416.
    Citations: 3     Fields:    Translation:HumansAnimals
  23. Obasi PC, Hebra A, Varela JC. Excision of esophageal duplication cysts with robotic-assisted thoracoscopic surgery. JSLS. 2011 Apr-Jun; 15(2):244-7. PMID: 21902985; PMCID: PMC3148881.
    Citations: 8     Fields:    Translation:Humans
  24. Schlosser RJ, Mulligan RM, Casey SE, Varela JC, Harvey RJ, Atkinson C. Alterations in gene expression of complement components in chronic rhinosinusitis. Am J Rhinol Allergy. 2010 Jan-Feb; 24(1):21-5. PMID: 20109314.
    Citations: 13     Fields:    Translation:HumansAnimals
  25. Atkinson C, Varela JC, Tomlinson S. Complement-dependent inflammation and injury in a murine model of brain dead donor hearts. Circ Res. 2009 Nov 20; 105(11):1094-101. PMID: 19815824; PMCID: PMC2783176.
    Citations: 18     Fields:    Translation:HumansAnimals
  26. Varela JC, Atkinson C, Woolson R, Keane TE, Tomlinson S. Upregulated expression of complement inhibitory proteins on bladder cancer cells and anti-MUC1 antibody immune selection. Int J Cancer. 2008 Sep 15; 123(6):1357-63. PMID: 18561323; PMCID: PMC2681224.
    Citations: 13     Fields:    Translation:Humans
  27. Varela JC, Imai M, Atkinson C, Ohta R, Rapisardo M, Tomlinson S. Modulation of protective T cell immunity by complement inhibitor expression on tumor cells. Cancer Res. 2008 Aug 15; 68(16):6734-42. PMID: 18701498; PMCID: PMC2681227.
    Citations: 14     Fields:    Translation:HumansAnimalsCells
  28. Imai M, Ohta R, Varela JC, Song H, Tomlinson S. Enhancement of antibody-dependent mechanisms of tumor cell lysis by a targeted activator of complement. Cancer Res. 2007 Oct 01; 67(19):9535-41. PMID: 17909064.
    Citations: 8     Fields:    Translation:HumansAnimals
  29. Atkinson C, Zhu H, Qiao F, Varela JC, Yu J, Song H, Kindy MS, Tomlinson S. Complement-dependent P-selectin expression and injury following ischemic stroke. J Immunol. 2006 Nov 15; 177(10):7266-74. PMID: 17082645.
    Citations: 41     Fields:    Translation:Animals
  30. Mikhitarian K, Gillanders WE, Almeida JS, Hebert Martin R, Varela JC, Metcalf JS, Cole DJ, Mitas M. An innovative microarray strategy identities informative molecular markers for the detection of micrometastatic breast cancer. Clin Cancer Res. 2005 May 15; 11(10):3697-704. PMID: 15897566.
    Citations: 9     Fields:    Translation:Humans
  31. Feezor RJ, Paddock HN, Baker HV, Varela JC, Barreda J, Moldawer LL, Schultz GS, Mozingo DW. Temporal patterns of gene expression in murine cutaneous burn wound healing. Physiol Genomics. 2004 Feb 13; 16(3):341-8. PMID: 14966252.
    Citations: 15     Fields:    Translation:Animals
  32. Paddock HN, Schultz GS, Baker HV, Varela JC, Beierle EA, Moldawer LL, Mozingo DW. Analysis of gene expression patterns in human postburn hypertrophic scars. J Burn Care Rehabil. 2003 Nov-Dec; 24(6):371-7. PMID: 14610421.
    Citations: 5     Fields:    Translation:HumansCells
  33. Brum LM, Lopez MC, Varela JC, Baker HV, Moyer RW. Microarray analysis of A549 cells infected with rabbitpox virus (RPV): a comparison of wild-type RPV and RPV deleted for the host range gene, SPI-1. Virology. 2003 Oct 25; 315(2):322-34. PMID: 14585335.
    Citations: 32     Fields:    Translation:HumansCells
  34. Blalock TD, Duncan MR, Varela JC, Goldstein MH, Tuli SS, Grotendorst GR, Schultz GS. Connective tissue growth factor expression and action in human corneal fibroblast cultures and rat corneas after photorefractive keratectomy. Invest Ophthalmol Vis Sci. 2003 May; 44(5):1879-87. PMID: 12714619.
    Citations: 49     Fields:    Translation:HumansAnimalsCells
  35. Varela JC, Goldstein MH, Baker HV, Schultz GS. Microarray analysis of gene expression patterns during healing of rat corneas after excimer laser photorefractive keratectomy. Invest Ophthalmol Vis Sci. 2002 Jun; 43(6):1772-82. PMID: 12036978.
    Citations: 10     Fields:    Translation:Animals
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.