Ramya Tokala | Harvard Catalyst Profiles

Ramya Tokala, Ph.D.

Title

Research Fellow in Radiology (EXT)

Institution

Massachusetts General Hospital

Department

Radiology

Address

Massachusetts General Hospital
55 Fruit St
Boston MA 02114

selected publications|

Bibliographic

selected publications

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.

Thatikonda S, Pooladanda V, Tokala R, Nagula S, Godugu C. Niclosamide inhibits epithelial-mesenchymal transition with apoptosis induction in BRAF/ NRAS mutated metastatic melanoma cells. Toxicol In Vitro. 2023 Mar 03; 89:105579. PMID: 36870549.

Citations: Fields:
Tox Toxicology
Shaikh AS, Kiranmai G, Parimala Devi G, Makhal PN, Sigalapalli DK, Tokala R, Kaki VR, Shankaraiah N, Nagesh N, Babu BN, Tangellamudi ND. Exploration of mercaptoacetamide-linked pyrimidine-1,3,4-oxadiazole derivatives as DNA intercalative topo II inhibitors: Cytotoxicity and apoptosis induction. Bioorg Med Chem Lett. 2022 06 01; 65:128697. PMID: 35339645.

Citations: 1 Fields:
Bio Biochemistry Che Chemistry
Translation:Humans Cells
Tokala R, Bora D, Shankaraiah N. Contribution of Knoevenagel Condensation Products toward the Development of Anticancer Agents: An Updated Review. ChemMedChem. 2022 04 20; 17(8):e202100736. PMID: 35226798.

Citations: 1 Fields:
Che Chemistry Pha Pharmacology
John SE, Bora D, Dhiman V, Tokala R, Samanthula G, Shankaraiah N. Ru(II)-Catalyzed Regioselective C-N Bond Formation on Benzothiazoles Employing Acyl Azide as an Amidating Agent. ACS Omega. 2022 Jan 11; 7(1):1299-1310. PMID: 35036791; PMCID: PMC8756580.

Citations:
Sigalapalli DK, Kiranmai G, Parimala Devi G, Tokala R, Sana S, Tripura C, Jadhav GS, Kadagathur M, Shankaraiah N, Nagesh N, Babu BN, Tangellamudi ND. Synthesis and biological evaluation of novel imidazo[1,2-a]pyridine-oxadiazole hybrids as anti-proliferative agents: Study of microtubule polymerization inhibition and DNA binding. Bioorg Med Chem. 2021 08 01; 43:116277. PMID: 34175586.

Citations: 2 Fields:
Bio Biochemistry Che Chemistry
Translation:Humans Cells
Sana S, Reddy VG, Srinivasa Reddy T, Tokala R, Kumar R, Bhargava SK, Shankaraiah N. Cinnamide derived pyrimidine-benzimidazole hybrids as tubulin inhibitors: Synthesis, in silico and cell growth inhibition studies. Bioorg Chem. 2021 05; 110:104765. PMID: 33677248.

Citations: 4 Fields:
Bio Biochemistry Che Chemistry
Translation:Humans Cells
Yadav U, Vanjari Y, Laxmikeshav K, Tokala R, Niggula PK, Kumar M, Talla V, Kamal A, Shankaraiah N. Synthesis and in Vitro Cytotoxicity Evaluation of Phenanthrene Linked 2,4- Thiazolidinediones as Potential Anticancer Agents. Anticancer Agents Med Chem. 2021; 21(9):1127-1140. PMID: 32664846.

Citations: 2 Fields:
Ant Antineoplastic Agents Che Chemistry
Translation:Humans Animals Cells
Tokala R, Mahajan S, Kiranmai G, Sigalapalli DK, Sana S, John SE, Nagesh N, Shankaraiah N. Development of ß-carboline-benzothiazole hybrids via carboxamide formation as cytotoxic agents: DNA intercalative topoisomerase IIa inhibition and apoptosis induction. Bioorg Chem. 2021 01; 106:104481. PMID: 33261848.

Citations: 3 Fields:
Bio Biochemistry Che Chemistry
Translation:Humans Cells
Tokala R, Sana S, Lakshmi UJ, Sankarana P, Sigalapalli DK, Gadewal N, Kode J, Shankaraiah N. Design and synthesis of thiadiazolo-carboxamide bridged ß-carboline-indole hybrids: DNA intercalative topo-IIa inhibition with promising antiproliferative activity. Bioorg Chem. 2020 12; 105:104357. PMID: 33091673; PMCID: PMC7543778.

Citations: 1 Fields:
Bio Biochemistry Che Chemistry
Translation:Humans Cells
Sana S, Reddy VG, Bhandari S, Reddy TS, Tokala R, Sakla AP, Bhargava SK, Shankaraiah N. Exploration of carbamide derived pyrimidine-thioindole conjugates as potential VEGFR-2 inhibitors with anti-angiogenesis effect. Eur J Med Chem. 2020 Aug 15; 200:112457. PMID: 32422489.

Citations: 10 Fields:
Che Chemistry
Translation:Humans Cells
Bhandari S, Sana S, Lahoti V, Tokala R, Shankaraiah N. Ring-opening cyclization of activated spiro-aziridine oxindoles with heteroarenes: a facile synthetic approach to spiro-oxindole-fused pyrroloindolines. RSC Adv. 2020 Apr 21; 10(27):16101-16109. PMID: 35493670; PMCID: PMC9052938.

Citations:
Bora D, Tokala R, John SE, Prasanth B, Shankaraiah N. ß-Carboline directed regioselective hydroxylation by employing Cu(OAc)2 and mechanistic investigation by ESI-MS. Org Biomol Chem. 2020 03 25; 18(12):2307-2311. PMID: 32159570.

Citations: 4 Fields:
Bio Biochemistry Che Chemistry
Jadala C, Sathish M, Anchi P, Tokala R, Lakshmi UJ, Reddy VG, Shankaraiah N, Godugu C, Kamal A. Synthesis of Combretastatin-A4 Carboxamidest that Mimic Sulfonyl Piperazines by a Molecular Hybridization Approach: in vitro Cytotoxicity Evaluation and Inhibition of Tubulin Polymerization. ChemMedChem. 2019 12 17; 14(24):2052-2060. PMID: 31674147.

Citations: 9 Fields:
Che Chemistry Pha Pharmacology
Translation:Humans Cells
Sana S, Tokala R, Bajaj DM, Nagesh N, Bokara KK, Kiranmai G, Lakshmi UJ, Vadlamani S, Talla V, Shankaraiah N. Design and synthesis of substituted dihydropyrimidinone derivatives as cytotoxic and tubulin polymerization inhibitors. Bioorg Chem. 2019 12; 93:103317. PMID: 31586714.

Citations: 4 Fields:
Bio Biochemistry Che Chemistry
Translation:Humans Cells
Shankaraiah N, Sakla AP, Laxmikeshav K, Tokala R. Reliability of Click Chemistry on Drug Discovery: A Personal Account. Chem Rec. 2020 Apr; 20(4):253-272. PMID: 31419056.

Citations: 5 Fields:
Che Chemistry
Translation:Humans Cells
Jadala C, Sathish M, Reddy TS, Reddy VG, Tokala R, Bhargava SK, Shankaraiah N, Nagesh N, Kamal A. Synthesis and in vitro cytotoxicity evaluation of ß-carboline-combretastatin carboxamides as apoptosis inducing agents: DNA intercalation and topoisomerase-II inhibition. Bioorg Med Chem. 2019 08 01; 27(15):3285-3298. PMID: 31227365.

Citations: 6 Fields:
Bio Biochemistry Che Chemistry
Translation:Humans Cells
Tokala R, Bora D, Sana S, Nachtigall FM, Santos LS, Shankaraiah N. Ru(II)-Catalyzed Regioselective Hydroxymethylation of ß-Carbolines and Isoquinolines via C-H Functionalization: Probing the Mechanism by Online ESI-MS/MS Screening. J Org Chem. 2019 05 03; 84(9):5504-5513. PMID: 30945857.

Citations: 6 Fields:
Che Chemistry
Sankara Rao N, Nagesh N, Lakshma Nayak V, Sunkari S, Tokala R, Kiranmai G, Regur P, Shankaraiah N, Kamal A. Design and synthesis of DNA-intercalative naphthalimide-benzothiazole/cinnamide derivatives: cytotoxicity evaluation and topoisomerase-IIa inhibition. Medchemcomm. 2019 Jan 01; 10(1):72-79. PMID: 30774856; PMCID: PMC6350626.

Citations: 4
Sathish M, Chetan Dushantrao S, Nekkanti S, Tokala R, Thatikonda S, Tangella Y, Srinivas G, Cherukommu S, Hari Krishna N, Shankaraiah N, Nagesh N, Kamal A. Synthesis of DNA interactive C3-trans-cinnamide linked ß-carboline conjugates as potential cytotoxic and DNA topoisomerase I inhibitors. Bioorg Med Chem. 2018 09 15; 26(17):4916-4929. PMID: 30172625.

Citations: 4 Fields:
Bio Biochemistry Che Chemistry
Translation:Humans Animals Cells
Tokala R, Thatikonda S, Vanteddu US, Sana S, Godugu C, Shankaraiah N. Design and Synthesis of DNA-Interactive ß-Carboline-Oxindole Hybrids as Cytotoxic and Apoptosis-Inducing Agents. ChemMedChem. 2018 09 19; 13(18):1909-1922. PMID: 30010248.

Citations: 8 Fields:
Che Chemistry Pha Pharmacology
Translation:Humans Cells
Tokala R, Bale S, Janrao IP, Vennela A, Kumar NP, Senwar KR, Godugu C, Shankaraiah N. Synthesis of 1,2,4-triazole-linked urea/thiourea conjugates as cytotoxic and apoptosis inducing agents. Bioorg Med Chem Lett. 2018 06 01; 28(10):1919-1924. PMID: 29657100.

Citations: 9 Fields:
Bio Biochemistry Che Chemistry
Translation:Humans Animals Cells
Kumar NP, Thatikonda S, Tokala R, Kumari SS, Lakshmi UJ, Godugu C, Shankaraiah N, Kamal A. Sulfamic acid promoted one-pot synthesis of phenanthrene fused-dihydrodibenzo-quinolinones: Anticancer activity, tubulin polymerization inhibition and apoptosis inducing studies. Bioorg Med Chem. 2018 05 01; 26(8):1996-2008. PMID: 29525336.

Citations: 4 Fields:
Bio Biochemistry Che Chemistry
Translation:Humans Cells
Nekkanti S, Tokala R, Shankaraiah N. Targeting DNA Minor Groove by Hybrid Molecules as Anticancer Agents. Curr Med Chem. 2017; 24(26):2887-2907. PMID: 28545367.

Citations: 8 Fields:
Che Chemistry
Translation:Humans Animals

Year	Publications
2017	1
2018	5
2019	5
2020	5
2021	4
2022	2
2023	1

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