Harvard Catalyst Profiles

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Seema Chugh, Ph.D.


Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Mannan R, Wang X, Bawa PS, Chugh S, Chinnaiyan AK, Rangaswamy R, Zhang Y, Cao X, Smith SC, Trpkov K, Williamson S, Sangoi AR, Mohanty S, McKenney JK, Gupta S, Magi-Galluzzi C, Argani P, Osunkoya AO, Chinnaiyan AM, Dhanasekaran SM, Mehra R. Characterization of Protein (2SC) Succination as a Biomarker for Fumarate Hydratase-deficient Renal Cell Carcinoma. Hum Pathol. 2022 Dec 26. PMID: 36581128.
    Citations:    Fields:    
  2. Li Y, Lih TM, Dhanasekaran SM, Mannan R, Chen L, Cieslik M, Wu Y, Lu RJ, Clark DJ, Kolodziejczak I, Hong R, Chen S, Zhao Y, Chugh S, Caravan W, Naser Al Deen N, Hosseini N, Newton CJ, Krug K, Xu Y, Cho KC, Hu Y, Zhang Y, Kumar-Sinha C, Ma W, Calinawan A, Wyczalkowski MA, Wendl MC, Wang Y, Guo S, Zhang C, Le A, Dagar A, Hopkins A, Cho H, Leprevost FDV, Jing X, Teo GC, Liu W, Reimers MA, Pachynski R, Lazar AJ, Chinnaiyan AM, Van Tine BA, Zhang B, Rodland KD, Getz G, Mani DR, Wang P, Chen F, Hostetter G, Thiagarajan M, Linehan WM, Fenyö D, Jewell SD, Omenn GS, Mehra R, Wiznerowicz M, Robles AI, Mesri M, Hiltke T, An E, Rodriguez H, Chan DW, Ricketts CJ, Nesvizhskii AI, Zhang H, Ding L. Histopathologic and proteogenomic heterogeneity reveals features of clear cell renal cell carcinoma aggressiveness. Cancer Cell. 2023 Jan 09; 41(1):139-163.e17. PMID: 36563681; PMCID: PMC9839644.
    Citations:    Fields:    Translation:Humans
  3. Siebenaler RF, Chugh S, Waninger JJ, Dommeti VL, Kenum C, Mody M, Gautam A, Patel N, Chu A, Bawa P, Hon J, Smith RD, Carlson H, Cao X, Tesmer JJG, Shankar S, Chinnaiyan AM. Argonaute 2 modulates EGFR-RAS signaling to promote mutant HRAS and NRAS-driven malignancies. PNAS Nexus. 2022 Jul; 1(3):pgac084. PMID: 35923912; PMCID: PMC9338400.
  4. Leon F, Seshacharyulu P, Nimmakayala RK, Chugh S, Karmakar S, Nallasamy P, Vengoji R, Rachagani S, Cox JL, Mallya K, Batra SK, Ponnusamy MP. Reduction in O-glycome induces differentially glycosylated CD44 to promote stemness and metastasis in pancreatic cancer. Oncogene. 2022 01; 41(1):57-71. PMID: 34675409; PMCID: PMC8727507.
    Citations: 4     Fields:    Translation:HumansCells
  5. Tien JC, Chugh S, Goodrum AE, Cheng Y, Mannan R, Zhang Y, Wang L, Dommeti VL, Wang X, Xu A, Hon J, Kenum C, Su F, Wang R, Cao X, Shankar S, Chinnaiyan AM. AGO2 promotes tumor progression in KRAS-driven mouse models of non-small cell lung cancer. Proc Natl Acad Sci U S A. 2021 05 18; 118(20). PMID: 33972443; PMCID: PMC8157917.
    Citations: 7     Fields:    Translation:AnimalsCells
  6. Nimmakayala RK, Leon F, Rachagani S, Rauth S, Nallasamy P, Marimuthu S, Shailendra GK, Chhonker YS, Chugh S, Chirravuri R, Gupta R, Mallya K, Prajapati DR, Lele SM, C Caffrey T, L Grem J, Grandgenett PM, Hollingsworth MA, Murry DJ, Batra SK, Ponnusamy MP. Metabolic programming of distinct cancer stem cells promotes metastasis of pancreatic ductal adenocarcinoma. Oncogene. 2021 01; 40(1):215-231. PMID: 33110235.
    Citations: 29     Fields:    Translation:HumansAnimalsCells
  7. Shankar S, Tien JC, Siebenaler RF, Chugh S, Dommeti VL, Zelenka-Wang S, Wang XM, Apel IJ, Waninger J, Eyunni S, Xu A, Mody M, Goodrum A, Zhang Y, Tesmer JJ, Mannan R, Cao X, Vats P, Pitchiaya S, Ellison SJ, Shi J, Kumar-Sinha C, Crawford HC, Chinnaiyan AM. An essential role for Argonaute 2 in EGFR-KRAS signaling in pancreatic cancer development. Nat Commun. 2020 06 04; 11(1):2817. PMID: 32499547; PMCID: PMC7272436.
    Citations: 14     Fields:    Translation:HumansAnimalsCells
  8. Gupta R, Leon F, Thompson CM, Nimmakayala R, Karmakar S, Nallasamy P, Chugh S, Prajapati DR, Rachagani S, Kumar S, Ponnusamy MP. Correction: Global analysis of human glycosyltransferases reveals novel targets for pancreatic cancer pathogenesis. Br J Cancer. 2020 May; 122(11):1726. PMID: 32286491; PMCID: PMC7251069.
    Citations: 1     Fields:    
  9. Gupta R, Leon F, Thompson CM, Nimmakayala R, Karmakar S, Nallasamy P, Chugh S, Prajapati DR, Rachagani S, Kumar S, Ponnusamy MP. Global analysis of human glycosyltransferases reveals novel targets for pancreatic cancer pathogenesis. Br J Cancer. 2020 05; 122(11):1661-1672. PMID: 32203219; PMCID: PMC7251111.
    Citations: 8     Fields:    Translation:HumansAnimals
  10. Barkeer S, Chugh S, Karmakar S, Kaushik G, Rauth S, Rachagani S, Batra SK, Ponnusamy MP. Novel role of O-glycosyltransferases GALNT3 and B3GNT3 in the self-renewal of pancreatic cancer stem cells. BMC Cancer. 2018 Nov 22; 18(1):1157. PMID: 30466404; PMCID: PMC6251200.
    Citations: 20     Fields:    Translation:HumansCells
  11. Chugh S, Barkeer S, Rachagani S, Nimmakayala RK, Perumal N, Pothuraju R, Atri P, Mahapatra S, Thapa I, Talmon GA, Smith LM, Yu X, Neelamegham S, Fu J, Xia L, Ponnusamy MP, Batra SK. Disruption of C1galt1 Gene Promotes Development and Metastasis of Pancreatic Adenocarcinomas in Mice. Gastroenterology. 2018 11; 155(5):1608-1624. PMID: 30086262; PMCID: PMC6219903.
    Citations: 37     Fields:    Translation:HumansAnimalsCells
  12. Barkeer S, Chugh S, Batra SK, Ponnusamy MP. Glycosylation of Cancer Stem Cells: Function in Stemness, Tumorigenesis, and Metastasis. Neoplasia. 2018 08; 20(8):813-825. PMID: 30015157; PMCID: PMC6037882.
    Citations: 26     Fields:    Translation:HumansAnimalsCells
  13. Nimmakayala RK, Seshacharyulu P, Lakshmanan I, Rachagani S, Chugh S, Karmakar S, Rauth S, Vengoji R, Atri P, Talmon GA, Lele SM, Smith LM, Thapa I, Bastola D, Ouellette MM, Batra SK, Ponnusamy MP. Cigarette Smoke Induces Stem Cell Features of Pancreatic Cancer Cells via PAF1. Gastroenterology. 2018 09; 155(3):892-908.e6. PMID: 29864419; PMCID: PMC6120776.
    Citations: 35     Fields:    Translation:HumansAnimalsCells
  14. Karmakar S, Seshacharyulu P, Lakshmanan I, Vaz AP, Chugh S, Sheinin YM, Mahapatra S, Batra SK, Ponnusamy MP. hPaf1/PD2 interacts with OCT3/4 to promote self-renewal of ovarian cancer stem cells. Oncotarget. 2017 Feb 28; 8(9):14806-14820. PMID: 28122356; PMCID: PMC5362445.
    Citations: 15     Fields:    Translation:HumansCells
  15. Chugh S, Meza J, Sheinin YM, Ponnusamy MP, Batra SK. Loss of N-acetylgalactosaminyltransferase 3 in poorly differentiated pancreatic cancer: augmented aggressiveness and aberrant ErbB family glycosylation. Br J Cancer. 2016 06 14; 114(12):1376-86. PMID: 27187683; PMCID: PMC4984453.
    Citations: 21     Fields:    Translation:HumansCells
  16. Pai P, Rachagani S, Dhawan P, Sheinin YM, Macha MA, Qazi AK, Chugh S, Ponnusamy MP, Mallya K, Pothuraju R, Batra SK. MUC4 is negatively regulated through the Wnt/ß-catenin pathway via the Notch effector Hath1 in colorectal cancer. Genes Cancer. 2016 May; 7(5-6):154-168. PMID: 27551331; PMCID: PMC4979589.
    Citations: 10     
  17. Muniyan S, Haridas D, Chugh S, Rachagani S, Lakshmanan I, Gupta S, Seshacharyulu P, Smith LM, Ponnusamy MP, Batra SK. MUC16 contributes to the metastasis of pancreatic ductal adenocarcinoma through focal adhesion mediated signaling mechanism. Genes Cancer. 2016 Mar; 7(3-4):110-124. PMID: 27382435; PMCID: PMC4918949.
    Citations: 45     
  18. Chugh S, Gnanapragassam VS, Jain M, Rachagani S, Ponnusamy MP, Batra SK. Pathobiological implications of mucin glycans in cancer: Sweet poison and novel targets. Biochim Biophys Acta. 2015 Dec; 1856(2):211-25. PMID: 26318196; PMCID: PMC4663118.
    Citations: 34     Fields:    Translation:HumansAnimals
  19. Rachagani S, Macha MA, Heimann N, Seshacharyulu P, Haridas D, Chugh S, Batra SK. Clinical implications of miRNAs in the pathogenesis, diagnosis and therapy of pancreatic cancer. Adv Drug Deliv Rev. 2015 Jan; 81:16-33. PMID: 25453266; PMCID: PMC4465296.
    Citations: 49     Fields:    Translation:HumansAnimals
  20. Haridas D, Ponnusamy MP, Chugh S, Lakshmanan I, Seshacharyulu P, Batra SK. MUC16: molecular analysis and its functional implications in benign and malignant conditions. FASEB J. 2014 Oct; 28(10):4183-99. PMID: 25002120.
    Citations: 59     Fields:    Translation:HumansAnimalsCells
  21. Ponnusamy MP, Seshacharyulu P, Lakshmanan I, Vaz AP, Chugh S, Batra SK. Emerging role of mucins in epithelial to mesenchymal transition. Curr Cancer Drug Targets. 2013 Nov; 13(9):945-56. PMID: 24168188; PMCID: PMC3924542.
    Citations: 27     Fields:    Translation:HumansAnimalsCells
  22. Chugh S, Anand V, Swaroop L, Sharma M, Seth A, Sharma A. Involvement of Th17 cells in patients of urothelial carcinoma of bladder. Hum Immunol. 2013 Oct; 74(10):1258-62. PMID: 23827655.
    Citations: 4     Fields:    Translation:HumansCells
  23. Gupta RK, Patel AK, Kumari R, Chugh S, Shrivastav C, Mehra S, Sharma AN. Interactions between oxidative stress, lipid profile and antioxidants in breast cancer: a case control study. Asian Pac J Cancer Prev. 2012; 13(12):6295-8. PMID: 23464448.
    Citations: 22     Fields:    Translation:Humans
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.