Harvard Catalyst Profiles

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Shinsuke Ohba, Ph.D., D.D.S.


Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Tani S, Okada H, Chung UI, Ohba S, Hojo H. The Progress of Stem Cell Technology for Skeletal Regeneration. Int J Mol Sci. 2021 Jan 30; 22(3). PMID: 33573345.
    Citations:    Fields:    
  2. Ohba S. Hedgehog Signaling in Skeletal Development: Roles of Indian Hedgehog and the Mode of Its Action. Int J Mol Sci. 2020 Sep 11; 21(18). PMID: 32933018.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  3. Tani S, Chung UI, Ohba S, Hojo H. Understanding paraxial mesoderm development and sclerotome specification for skeletal repair. Exp Mol Med. 2020 08; 52(8):1166-1177. PMID: 32788657.
    Citations: 1     Fields:    
  4. Onodera S, Saito A, Hojo H, Nakamura T, Zujur D, Watanabe K, Morita N, Hasegawa D, Masaki H, Nakauchi H, Nomura T, Shibahara T, Yamaguchi A, Chung UI, Azuma T, Ohba S. Hedgehog Activation Regulates Human Osteoblastogenesis. Stem Cell Reports. 2020 07 14; 15(1):125-139. PMID: 32531191.
    Citations: 3     Fields:    
  5. Zujur D, Kanke K, Onodera S, Tani S, Lai J, Azuma T, Xin X, Lichtler AC, Rowe DW, Saito T, Tanaka S, Masaki H, Nakauchi H, Chung UI, Hojo H, Ohba S. Stepwise strategy for generating osteoblasts from human pluripotent stem cells under fully defined xeno-free conditions with small-molecule inducers. Regen Ther. 2020 Jun; 14:19-31. PMID: 31988991.
    Citations: 1     
  6. Hojo H, Ohba S. Insights into Gene Regulatory Networks in Chondrocytes. Int J Mol Sci. 2019 Dec 15; 20(24). PMID: 31847446.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  7. Xuan F, Yano F, Mori D, Chijimatsu R, Maenohara Y, Nakamoto H, Mori Y, Makii Y, Oichi T, Taketo MM, Hojo H, Ohba S, Chung UI, Tanaka S, Saito T. Wnt/ß-catenin signaling contributes to articular cartilage homeostasis through lubricin induction in the superficial zone. Arthritis Res Ther. 2019 11 27; 21(1):247. PMID: 31771658.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  8. Kawata M, Mori D, Kanke K, Hojo H, Ohba S, Chung UI, Yano F, Masaki H, Otsu M, Nakauchi H, Tanaka S, Saito T. Simple and Robust Differentiation of Human Pluripotent Stem Cells toward Chondrocytes by Two Small-Molecule Compounds. Stem Cell Reports. 2019 09 10; 13(3):530-544. PMID: 31402337.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  9. Yano F, Ohba S, Murahashi Y, Tanaka S, Saito T, Chung UI. Runx1 contributes to articular cartilage maintenance by enhancement of cartilage matrix production and suppression of hypertrophic differentiation. Sci Rep. 2019 05 21; 9(1):7666. PMID: 31113964.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  10. Ohba S, Hojo H, Chung UI. A report of the 17th congress of the Japanese Society for Regenerative Medicine. Regen Ther. 2018 Dec; 9:10-14. PMID: 30525070.
  11. Tan Z, Niu B, Tsang KY, Melhado IG, Ohba S, He X, Huang Y, Wang C, McMahon AP, Jauch R, Chan D, Zhang MQ, Cheah KSE. Synergistic co-regulation and competition by a SOX9-GLI-FOXA phasic transcriptional network coordinate chondrocyte differentiation transitions. PLoS Genet. 2018 04; 14(4):e1007346. PMID: 29659575.
    Citations: 13     Fields:    Translation:AnimalsCells
  12. Fujii Y, Kawase-Koga Y, Hojo H, Yano F, Sato M, Chung UI, Ohba S, Chikazu D. Bone regeneration by human dental pulp stem cells using a helioxanthin derivative and cell-sheet technology. Stem Cell Res Ther. 2018 02 01; 9(1):24. PMID: 29391049.
    Citations: 15     Fields:    Translation:HumansAnimalsCells
  13. Furuya M, Kikuta J, Fujimori S, Seno S, Maeda H, Shirazaki M, Uenaka M, Mizuno H, Iwamoto Y, Morimoto A, Hashimoto K, Ito T, Isogai Y, Kashii M, Kaito T, Ohba S, Chung UI, Lichtler AC, Kikuchi K, Matsuda H, Yoshikawa H, Ishii M. Direct cell-cell contact between mature osteoblasts and osteoclasts dynamically controls their functions in vivo. Nat Commun. 2018 01 19; 9(1):300. PMID: 29352112.
    Citations: 25     Fields:    Translation:AnimalsCells
  14. Hojo H, Chung UI, Ohba S. Identification of the gene-regulatory landscape in skeletal development and potential links to skeletal regeneration. Regen Ther. 2017 Jun; 6:100-107. PMID: 30271844.
    Citations: 1     
  15. Zujur D, Kanke K, Lichtler AC, Hojo H, Chung UI, Ohba S. Three-dimensional system enabling the maintenance and directed differentiation of pluripotent stem cells under defined conditions. Sci Adv. 2017 May; 3(5):e1602875. PMID: 28508073.
    Citations: 12     Fields:    Translation:AnimalsCells
  16. Kawata M, Taniguchi Y, Mori D, Yano F, Ohba S, Chung UI, Shimogori T, Mills AA, Tanaka S, Saito T. Different regulation of limb development by p63 transcript variants. PLoS One. 2017; 12(3):e0174122. PMID: 28333962.
    Citations:    Fields:    Translation:Animals
  17. Hojo H, McMahon AP, Ohba S. An Emerging Regulatory Landscape for Skeletal Development. Trends Genet. 2016 12; 32(12):774-787. PMID: 27814929.
    Citations: 5     Fields:    Translation:AnimalsCells
  18. Kashiwagi M, Hojo H, Kitaura Y, Maeda Y, Aini H, Takato T, Chung UI, Ohba S. Local administration of a hedgehog agonist accelerates fracture healing in a mouse model. Biochem Biophys Res Commun. 2016 Oct 28; 479(4):772-778. PMID: 27693795.
    Citations: 2     Fields:    Translation:AnimalsCells
  19. Honnami M, Choi S, Liu IL, Kamimura W, Taguchi T, Ichimura M, Urushisaki Y, Hojo H, Shimohata N, Ohba S, Amaya K, Koyama H, Nishimura R, Chung UI, Sasaki N, Mochizuki M. Repair of segmental radial defects in dogs using tailor-made titanium mesh cages with plates combined with calcium phosphate granules and basic fibroblast growth factor-binding ion complex gel. J Artif Organs. 2017 Mar; 20(1):91-98. PMID: 27485094.
    Citations: 2     Fields:    Translation:Animals
  20. He X, Ohba S, Hojo H, McMahon AP. AP-1 family members act with Sox9 to promote chondrocyte hypertrophy. Development. 2016 08 15; 143(16):3012-23. PMID: 27471255.
    Citations: 18     Fields:    Translation:HumansAnimalsCells
  21. Hojo H, Ohba S, He X, Lai LP, McMahon AP. Sp7/Osterix Is Restricted to Bone-Forming Vertebrates where It Acts as a Dlx Co-factor in Osteoblast Specification. Dev Cell. 2016 05 09; 37(3):238-53. PMID: 27134141.
    Citations: 24     Fields:    Translation:AnimalsCells
  22. Aini H, Itaka K, Fujisawa A, Uchida H, Uchida S, Fukushima S, Kataoka K, Saito T, Chung UI, Ohba S. Messenger RNA delivery of a cartilage-anabolic transcription factor as a disease-modifying strategy for osteoarthritis treatment. Sci Rep. 2016 Jan 05; 6:18743. PMID: 26728350.
    Citations: 23     Fields:    Translation:Animals
  23. Ohba S, He X, Hojo H, McMahon AP. Distinct Transcriptional Programs Underlie Sox9 Regulation of the Mammalian Chondrocyte. Cell Rep. 2015 Jul 14; 12(2):229-43. PMID: 26146088.
    Citations: 62     Fields:    Translation:HumansAnimalsCells
  24. Maeda Y, Yamamoto K, Yamakawa A, Aini H, Takato T, Chung UI, Ohba S. The H2 blocker famotidine suppresses progression of ossification of the posterior longitudinal ligament in a mouse model. RMD Open. 2015; 1(1):e000068. PMID: 26509067.
  25. Sugita S, Hosaka Y, Okada K, Mori D, Yano F, Kobayashi H, Taniguchi Y, Mori Y, Okuma T, Chang SH, Kawata M, Taketomi S, Chikuda H, Akiyama H, Kageyama R, Chung UI, Tanaka S, Kawaguchi H, Ohba S, Saito T. Transcription factor Hes1 modulates osteoarthritis development in cooperation with calcium/calmodulin-dependent protein kinase 2. Proc Natl Acad Sci U S A. 2015 Mar 10; 112(10):3080-5. PMID: 25733872.
    Citations: 29     Fields:    Translation:HumansAnimalsCells
  26. Hojo H, Ohba S, Chung UI. Signaling pathways regulating the specification and differentiation of the osteoblast lineage. Regen Ther. 2015 Jun; 1:57-62. PMID: 31245441.
    Citations: 5     
  27. Kitaura Y, Hojo H, Komiyama Y, Takato T, Chung UI, Ohba S. Gli1 haploinsufficiency leads to decreased bone mass with an uncoupling of bone metabolism in adult mice. PLoS One. 2014; 9(10):e109597. PMID: 25313900.
    Citations: 12     Fields:    Translation:AnimalsCells
  28. Yano F, Ohba S, Hosaka Y, Saito T, Chung UI. Disease-modifying effects of TD-198946 on progressed osteoarthritis in a mouse model. Ann Rheum Dis. 2014 Nov; 73(11):2062-4. PMID: 25135252.
    Citations:    Fields:    Translation:Animals
  29. Choi S, Liu IL, Yamamoto K, Honnami M, Ohba S, Echigo R, Sakai T, Igawa K, Suzuki S, Nishimura R, Chung UI, Sasaki N, Mochizuki M. Comparison of the long-term effects on rabbit bone defects between Tetrabone and ß-tricalcium phosphate granules implantation. J Artif Organs. 2014 Dec; 17(4):344-51. PMID: 25116218.
    Citations: 1     Fields:    Translation:Animals
  30. Kanke K, Masaki H, Saito T, Komiyama Y, Hojo H, Nakauchi H, Lichtler AC, Takato T, Chung UI, Ohba S. Stepwise differentiation of pluripotent stem cells into osteoblasts using four small molecules under serum-free and feeder-free conditions. Stem Cell Reports. 2014 Jun 03; 2(6):751-60. PMID: 24936463.
    Citations: 26     Fields:    Translation:HumansAnimalsCells
  31. Ha BG, Yonezawa T, Son MJ, Woo JT, Ohba S, Chung UI, Yagasaki K. Antidiabetic effect of nepodin, a component of Rumex roots, and its modes of action in vitro and in vivo. Biofactors. 2014 Jul-Aug; 40(4):436-47. PMID: 24756979.
    Citations: 4     Fields:    Translation:AnimalsCells
  32. Honnami M, Choi S, Liu IL, Kamimura W, Taguchi T, Hojo H, Shimohata N, Ohba S, Koyama H, Nishimura R, Chung UI, Sasaki N, Mochizuki M. Bone regeneration by the combined use of tetrapod-shaped calcium phosphate granules with basic fibroblast growth factor-binding ion complex gel in canine segmental radial defects. J Vet Med Sci. 2014 Jul; 76(7):955-61. PMID: 24670963.
    Citations: 1     Fields:    Translation:AnimalsCellsCTClinical Trials
  33. Zhang X, Peterson KA, Liu XS, McMahon AP, Ohba S. Gene regulatory networks mediating canonical Wnt signal-directed control of pluripotency and differentiation in embryo stem cells. Stem Cells. 2013 Dec; 31(12):2667-79. PMID: 23505158.
    Citations: 47     Fields:    Translation:AnimalsCells
  34. Ohba S, Chung UI, Tei Y. [Identification of osteogenic signal and the development of artificial bones]. Clin Calcium. 2013 Dec; 23(12):1723-9. PMID: 24292526.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  35. Choi S, Liu IL, Yamamoto K, Honnami M, Sakai T, Ohba S, Echigo R, Suzuki S, Nishimura R, Chung UI, Sasaki N, Mochizuki M. Implantation of tetrapod-shaped granular artificial bones or ß-tricalcium phosphate granules in a canine large bone-defect model. J Vet Med Sci. 2014 Mar 01; 76(2):229-35. PMID: 24161964.
    Citations: 1     Fields:    Translation:Animals
  36. Saito T, Yano F, Mori D, Ohba S, Hojo H, Otsu M, Eto K, Nakauchi H, Tanaka S, Chung UI, Kawaguchi H. Generation of Col2a1-EGFP iPS cells for monitoring chondrogenic differentiation. PLoS One. 2013; 8(9):e74137. PMID: 24066106.
    Citations: 5     Fields:    Translation:AnimalsCells
  37. Honnami M, Choi S, Liu IL, Kamimura W, Taguchi T, Hojo H, Shimohata N, Ohba S, Koyama H, Nishimura R, Chung UI, Sasaki N, Mochizuki M. Repair of rabbit segmental femoral defects by using a combination of tetrapod-shaped calcium phosphate granules and basic fibroblast growth factor-binding ion complex gel. Biomaterials. 2013 Dec; 34(36):9056-62. PMID: 23981356.
    Citations: 4     Fields:    Translation:HumansAnimals
  38. Yano F, Hojo H, Ohba S, Saito T, Honnami M, Mochizuki M, Takato T, Kawaguchi H, Chung UI. Cell-sheet technology combined with a thienoindazole derivative small compound TD-198946 for cartilage regeneration. Biomaterials. 2013 Jul; 34(22):5581-7. PMID: 23623324.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  39. Maeda Y, Hojo H, Shimohata N, Choi S, Yamamoto K, Takato T, Chung UI, Ohba S. Bone healing by sterilizable calcium phosphate tetrapods eluting osteogenic molecules. Biomaterials. 2013 Jul; 34(22):5530-7. PMID: 23623228.
    Citations: 10     Fields:    Translation:AnimalsCellsPHPublic Health
  40. Komiyama Y, Ohba S, Shimohata N, Nakajima K, Hojo H, Yano F, Takato T, Docheva D, Shukunami C, Hiraki Y, Chung UI. Tenomodulin expression in the periodontal ligament enhances cellular adhesion. PLoS One. 2013; 8(4):e60203. PMID: 23593173.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  41. Hojo H, Ohba S, Taniguchi K, Shirai M, Yano F, Saito T, Ikeda T, Nakajima K, Komiyama Y, Nakagata N, Suzuki K, Mishina Y, Yamada M, Konno T, Takato T, Kawaguchi H, Kambara H, Chung UI. Hedgehog-Gli activators direct osteo-chondrogenic function of bone morphogenetic protein toward osteogenesis in the perichondrium. J Biol Chem. 2013 Apr 05; 288(14):9924-9932. PMID: 23423383.
    Citations: 24     Fields:    Translation:AnimalsCells
  42. Wu S, Kasim V, Kano MR, Tanaka S, Ohba S, Miura Y, Miyata K, Liu X, Matsuhashi A, Chung UI, Yang L, Kataoka K, Nishiyama N, Miyagishi M. Transcription factor YY1 contributes to tumor growth by stabilizing hypoxia factor HIF-1a in a p53-independent manner. Cancer Res. 2013 Mar 15; 73(6):1787-99. PMID: 23328582.
    Citations: 26     Fields:    Translation:HumansCells
  43. Ogasawara T, Ohba S, Yano F, Kawaguchi H, Chung UI, Saito T, Yonehara Y, Nakatsuka T, Mori Y, Takato T, Hoshi K. Nanog promotes osteogenic differentiation of the mouse mesenchymal cell line C3H10T1/2 by modulating bone morphogenetic protein (BMP) signaling. J Cell Physiol. 2013 Jan; 228(1):163-71. PMID: 22585661.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  44. Ohba S, Hojo H, Chung UI. Bioactive factors for tissue regeneration: state of the art. Muscles Ligaments Tendons J. 2012 Jul; 2(3):193-203. PMID: 23738297.
    Citations: 5     
  45. Yano F, Hojo H, Ohba S, Fukai A, Hosaka Y, Ikeda T, Saito T, Hirata M, Chikuda H, Takato T, Kawaguchi H, Chung UI. A novel disease-modifying osteoarthritis drug candidate targeting Runx1. Ann Rheum Dis. 2013 May; 72(5):748-53. PMID: 23041841.
    Citations: 26     Fields:    Translation:Animals
  46. Yamamoto K, Hojo H, Koshima I, Chung UI, Ohba S. Famotidine suppresses osteogenic differentiation of tendon cells in vitro and pathological calcification of tendon in vivo. J Orthop Res. 2012 Dec; 30(12):1958-62. PMID: 22592911.
    Citations: 2     Fields:    Translation:AnimalsCells
  47. Hojo H, Ohba S, Yano F, Saito T, Ikeda T, Nakajima K, Komiyama Y, Nakagata N, Suzuki K, Takato T, Kawaguchi H, Chung UI. Gli1 protein participates in Hedgehog-mediated specification of osteoblast lineage during endochondral ossification. J Biol Chem. 2012 May 18; 287(21):17860-17869. PMID: 22493482.
    Citations: 38     Fields:    Translation:AnimalsCells
  48. Hojo H, Ohba S, Yano F, Chung UI. Coordination of chondrogenesis and osteogenesis by hypertrophic chondrocytes in endochondral bone development. J Bone Miner Metab. 2010 Sep; 28(5):489-502. PMID: 20607327.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  49. Saito T, Fukai A, Mabuchi A, Ikeda T, Yano F, Ohba S, Nishida N, Akune T, Yoshimura N, Nakagawa T, Nakamura K, Tokunaga K, Chung UI, Kawaguchi H. Transcriptional regulation of endochondral ossification by HIF-2alpha during skeletal growth and osteoarthritis development. Nat Med. 2010 Jun; 16(6):678-86. PMID: 20495570.
    Citations: 175     Fields:    Translation:HumansAnimalsCells
  50. Nakajima K, Komiyama Y, Hojo H, Ohba S, Yano F, Nishikawa N, Ihara S, Aburatani H, Takato T, Chung UI. Enhancement of bone formation ex vivo and in vivo by a helioxanthin-derivative. Biochem Biophys Res Commun. 2010 May 14; 395(4):502-8. PMID: 20382113.
    Citations: 6     Fields:    Translation:AnimalsCells
  51. Hojo H, Yano F, Ohba S, Igawa K, Nakajima K, Komiyama Y, Kan A, Ikeda T, Yonezawa T, Woo JT, Takato T, Nakamura K, Kawaguchi H, Chung UI. Identification of oxytetracycline as a chondrogenic compound using a cell-based screening system. J Bone Miner Metab. 2010 Nov; 28(6):627-33. PMID: 20376510.
    Citations: 6     Fields:    Translation:AnimalsCells
  52. Zhao J, Ohba S, Komiyama Y, Shinkai M, Chung UI, Nagamune T. Icariin: a potential osteoinductive compound for bone tissue engineering. Tissue Eng Part A. 2010 Jan; 16(1):233-43. PMID: 19698057.
    Citations: 24     Fields:    Translation:AnimalsCells
  53. Zhao J, Shinkai M, Takezawa T, Ohba S, Chung UI, Nagamune T. Bone regeneration using collagen type I vitrigel with bone morphogenetic protein-2. J Biosci Bioeng. 2009 Mar; 107(3):318-23. PMID: 19269600.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  54. Hirata M, Kugimiya F, Fukai A, Ohba S, Kawamura N, Ogasawara T, Kawasaki Y, Saito T, Yano F, Ikeda T, Nakamura K, Chung UI, Kawaguchi H. C/EBPbeta Promotes transition from proliferation to hypertrophic differentiation of chondrocytes through transactivation of p57. PLoS One. 2009; 4(2):e4543. PMID: 19229324.
    Citations: 40     Fields:    Translation:AnimalsCells
  55. Wang W, Itaka K, Ohba S, Nishiyama N, Chung UI, Yamasaki Y, Kataoka K. 3D spheroid culture system on micropatterned substrates for improved differentiation efficiency of multipotent mesenchymal stem cells. Biomaterials. 2009 May; 30(14):2705-15. PMID: 19215979.
    Citations: 84     Fields:    Translation:HumansCells
  56. Higashikawa A, Saito T, Ikeda T, Kamekura S, Kawamura N, Kan A, Oshima Y, Ohba S, Ogata N, Takeshita K, Nakamura K, Chung UI, Kawaguchi H. Identification of the core element responsive to runt-related transcription factor 2 in the promoter of human type X collagen gene. Arthritis Rheum. 2009 Jan; 60(1):166-78. PMID: 19116917.
    Citations: 27     Fields:    Translation:HumansAnimalsCells
  57. Ogata N, Chung UI, Tei Y, Ohba S, Kawaguchi H. [Optimization of signaling pathways for bone regeneration]. Clin Calcium. 2008 Dec; 18(12):1707-12. PMID: 19043183.
    Citations:    Fields:    Translation:HumansAnimalsCells
  58. Hojo H, Igawa K, Ohba S, Yano F, Nakajima K, Komiyama Y, Ikeda T, Lichtler AC, Woo JT, Yonezawa T, Takato T, Chung UI. Development of high-throughput screening system for osteogenic drugs using a cell-based sensor. Biochem Biophys Res Commun. 2008 Nov 14; 376(2):375-9. PMID: 18789892.
    Citations: 6     Fields:    Translation:AnimalsCells
  59. Ohba S, Kawaguchi H, Kugimiya F, Ogasawara T, Kawamura N, Saito T, Ikeda T, Fujii K, Miyajima T, Kuramochi A, Miyashita T, Oda H, Nakamura K, Takato T, Chung UI. Patched1 haploinsufficiency increases adult bone mass and modulates Gli3 repressor activity. Dev Cell. 2008 May; 14(5):689-99. PMID: 18477452.
    Citations: 54     Fields:    Translation:HumansAnimalsCells
  60. Tamiya H, Ikeda T, Jeong JH, Saito T, Yano F, Jung YK, Ohba S, Kawaguchi H, Chung UI, Choi JY. Analysis of the Runx2 promoter in osseous and non-osseous cells and identification of HIF2A as a potent transcription activator. Gene. 2008 Jun 15; 416(1-2):53-60. PMID: 18442887.
    Citations: 20     Fields:    Translation:HumansAnimalsCells
  61. Zhao J, Ohba S, Shinkai M, Chung UI, Nagamune T. Icariin induces osteogenic differentiation in vitro in a BMP- and Runx2-dependent manner. Biochem Biophys Res Commun. 2008 May 02; 369(2):444-8. PMID: 18295595.
    Citations: 39     Fields:    Translation:AnimalsCells
  62. Ohba S, Chung UI, Tei Y. [Osteoblast differentiation induced by BMP signaling and Runx2 through Cbfb regulation]. Nihon Rinsho. 2007 Nov 28; 65 Suppl 9:71-4. PMID: 18161084.
    Citations:    Fields:    Translation:HumansAnimalsCells
  63. Kawamura N, Kugimiya F, Oshima Y, Ohba S, Ikeda T, Saito T, Shinoda Y, Kawasaki Y, Ogata N, Hoshi K, Akiyama T, Chen WS, Hay N, Tobe K, Kadowaki T, Azuma Y, Tanaka S, Nakamura K, Chung UI, Kawaguchi H. Akt1 in osteoblasts and osteoclasts controls bone remodeling. PLoS One. 2007 Oct 24; 2(10):e1058. PMID: 17957242.
    Citations: 84     Fields:    Translation:HumansAnimalsCells
  64. Kugimiya F, Kawaguchi H, Ohba S, Kawamura N, Hirata M, Chikuda H, Azuma Y, Woodgett JR, Nakamura K, Chung UI. GSK-3beta controls osteogenesis through regulating Runx2 activity. PLoS One. 2007 Sep 05; 2(9):e837. PMID: 17786208.
    Citations: 56     Fields:    Translation:AnimalsCells
  65. Itaka K, Ohba S, Miyata K, Kawaguchi H, Nakamura K, Takato T, Chung UI, Kataoka K. Bone regeneration by regulated in vivo gene transfer using biocompatible polyplex nanomicelles. Mol Ther. 2007 Sep; 15(9):1655-62. PMID: 17551504.
    Citations: 26     Fields:    Translation:HumansAnimalsCells
  66. Ohba S, Nakajima K, Komiyama Y, Kugimiya F, Igawa K, Itaka K, Moro T, Nakamura K, Kawaguchi H, Takato T, Chung UI. A novel osteogenic helioxanthin-derivative acts in a BMP-dependent manner. Biochem Biophys Res Commun. 2007 Jun 15; 357(4):854-60. PMID: 17451649.
    Citations: 13     Fields:    Translation:AnimalsCells
  67. Ohba S, Ikeda T, Kugimiya F, Yano F, Lichtler AC, Nakamura K, Takato T, Kawaguchi H, Chung UI. Identification of a potent combination of osteogenic genes for bone regeneration using embryonic stem (ES) cell-based sensor. FASEB J. 2007 Jun; 21(8):1777-87. PMID: 17317722.
    Citations: 13     Fields:    Translation:AnimalsCells
  68. Kugimiya F, Ohba S, Nakamura K, Kawaguchi H, Chung UI. Physiological role of bone morphogenetic proteins in osteogenesis. J Bone Miner Metab. 2006; 24(2):95-9. PMID: 16502114.
    Citations: 3     Fields:    Translation:AnimalsCells
  69. Kugimiya F, Yano F, Ohba S, Igawa K, Nakamura K, Kawaguchi H, Chung UI. Mechanism of osteogenic induction by FK506 via BMP/Smad pathways. Biochem Biophys Res Commun. 2005 Dec 16; 338(2):872-9. PMID: 16246307.
    Citations: 16     Fields:    Translation:AnimalsCells
  70. Kugimiya F, Kawaguchi H, Kamekura S, Chikuda H, Ohba S, Yano F, Ogata N, Katagiri T, Harada Y, Azuma Y, Nakamura K, Chung UI. Involvement of endogenous bone morphogenetic protein (BMP) 2 and BMP6 in bone formation. J Biol Chem. 2005 Oct 21; 280(42):35704-12. PMID: 16109715.
    Citations: 44     Fields:    Translation:AnimalsCells
  71. Yano F, Kugimiya F, Ohba S, Ikeda T, Chikuda H, Ogasawara T, Ogata N, Takato T, Nakamura K, Kawaguchi H, Chung UI. The canonical Wnt signaling pathway promotes chondrocyte differentiation in a Sox9-dependent manner. Biochem Biophys Res Commun. 2005 Aug 12; 333(4):1300-8. PMID: 15979579.
    Citations: 53     Fields:    Translation:AnimalsCells
  72. Kawaguchi H, Akune T, Yamaguchi M, Ohba S, Ogata N, Chung UI, Kubota N, Terauchi Y, Kadowaki T, Nakamura K. Distinct effects of PPARgamma insufficiency on bone marrow cells, osteoblasts, and osteoclastic cells. J Bone Miner Metab. 2005; 23(4):275-9. PMID: 15981022.
    Citations: 27     Fields:    Translation:HumansAnimalsCells
  73. Ohba S, Igawa K, Nakamura K, Kawaguchi H, Takato T, Chung UI. [Regenerative medicine of bone and cartilage]. Nihon Ronen Igakkai Zasshi. 2004 Nov; 41(6):582-8. PMID: 15651365.
    Citations:    Fields:    Translation:HumansAnimals
  74. Akune T, Ohba S, Kamekura S, Yamaguchi M, Chung UI, Kubota N, Terauchi Y, Harada Y, Azuma Y, Nakamura K, Kadowaki T, Kawaguchi H. PPARgamma insufficiency enhances osteogenesis through osteoblast formation from bone marrow progenitors. J Clin Invest. 2004 Mar; 113(6):846-55. PMID: 15067317.
    Citations: 326     Fields:    Translation:AnimalsCells
  75. Long F, Chung UI, Ohba S, McMahon J, Kronenberg HM, McMahon AP. Ihh signaling is directly required for the osteoblast lineage in the endochondral skeleton. Development. 2004 Mar; 131(6):1309-18. PMID: 14973297.
    Citations: 129     Fields:    Translation:AnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.