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profileShinsuke Ohba, Ph.D., D.D.S.

TitlePost Doc, Visiting (Stip) (EXT)
InstitutionFaculty of Arts & Sciences
DepartmentStem Cell and Regenerative Biology
AddressHarvard, Stem Cell and Regenerative Biology
Biological Lab - McMahon Lab
16 Divinity Ave
Cambridge MA 02138
Phone617/496-3748
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Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Zujur D, Kanke K, Lichtler AC, Hojo H, Chung UI, Ohba S. Three-dimensional system enabling the maintenance and directed differentiation of pluripotent stem cells under defined conditions. Sci Adv. 2017 May; 3(5):e1602875. PMID: 28508073.
    View in: PubMed
  2. Kawata M, Taniguchi Y, Mori D, Yano F, Ohba S, Chung UI, Shimogori T, Mills AA, Tanaka S, Saito T. Different regulation of limb development by p63 transcript variants. PLoS One. 2017; 12(3):e0174122. PMID: 28333962.
    View in: PubMed
  3. Hojo H, McMahon AP, Ohba S. An Emerging Regulatory Landscape for Skeletal Development. Trends Genet. 2016 Dec; 32(12):774-787. PMID: 27814929.
    View in: PubMed
  4. Kashiwagi M, Hojo H, Kitaura Y, Maeda Y, Aini H, Takato T, Chung UI, Ohba S. Local administration of a hedgehog agonist accelerates fracture healing in a mouse model. Biochem Biophys Res Commun. 2016 Oct 28; 479(4):772-778. PMID: 27693795.
    View in: PubMed
  5. Honnami M, Choi S, Liu IL, Kamimura W, Taguchi T, Ichimura M, Urushisaki Y, Hojo H, Shimohata N, Ohba S, Amaya K, Koyama H, Nishimura R, Chung UI, Sasaki N, Mochizuki M. Repair of segmental radial defects in dogs using tailor-made titanium mesh cages with plates combined with calcium phosphate granules and basic fibroblast growth factor-binding ion complex gel. J Artif Organs. 2017 Mar; 20(1):91-98. PMID: 27485094.
    View in: PubMed
  6. He X, Ohba S, Hojo H, McMahon AP. AP-1 family members act with Sox9 to promote chondrocyte hypertrophy. Development. 2016 Aug 15; 143(16):3012-23. PMID: 27471255; PMCID: PMC5004882 [Available on 08/15/17].
  7. Hojo H, Ohba S, He X, Lai LP, McMahon AP. Sp7/Osterix Is Restricted to Bone-Forming Vertebrates where It Acts as a Dlx Co-factor in Osteoblast Specification. Dev Cell. 2016 May 09; 37(3):238-53. PMID: 27134141; PMCID: PMC4964983 [Available on 05/09/17].
  8. Aini H, Itaka K, Fujisawa A, Uchida H, Uchida S, Fukushima S, Kataoka K, Saito T, Chung UI, Ohba S. Messenger RNA delivery of a cartilage-anabolic transcription factor as a disease-modifying strategy for osteoarthritis treatment. Sci Rep. 2016 Jan 05; 6:18743. PMID: 26728350; PMCID: PMC4700530.
  9. Ohba S, He X, Hojo H, McMahon AP. Distinct Transcriptional Programs Underlie Sox9 Regulation of the Mammalian Chondrocyte. Cell Rep. 2015 Jul 14; 12(2):229-43. PMID: 26146088; PMCID: PMC4504750.
  10. Maeda Y, Yamamoto K, Yamakawa A, Aini H, Takato T, Chung UI, Ohba S. The H2 blocker famotidine suppresses progression of ossification of the posterior longitudinal ligament in a mouse model. RMD Open. 2015; 1(1):e000068. PMID: 26509067; PMCID: PMC4612692.
  11. Sugita S, Hosaka Y, Okada K, Mori D, Yano F, Kobayashi H, Taniguchi Y, Mori Y, Okuma T, Chang SH, Kawata M, Taketomi S, Chikuda H, Akiyama H, Kageyama R, Chung UI, Tanaka S, Kawaguchi H, Ohba S, Saito T. Transcription factor Hes1 modulates osteoarthritis development in cooperation with calcium/calmodulin-dependent protein kinase 2. Proc Natl Acad Sci U S A. 2015 Mar 10; 112(10):3080-5. PMID: 25733872; PMCID: PMC4364241.
  12. Kitaura Y, Hojo H, Komiyama Y, Takato T, Chung UI, Ohba S. Gli1 haploinsufficiency leads to decreased bone mass with an uncoupling of bone metabolism in adult mice. PLoS One. 2014; 9(10):e109597. PMID: 25313900; PMCID: PMC4196929.
  13. Yano F, Ohba S, Hosaka Y, Saito T, Chung UI. Disease-modifying effects of TD-198946 on progressed osteoarthritis in a mouse model. Ann Rheum Dis. 2014 Nov; 73(11):2062-4. PMID: 25135252.
    View in: PubMed
  14. Choi S, Liu IL, Yamamoto K, Honnami M, Ohba S, Echigo R, Sakai T, Igawa K, Suzuki S, Nishimura R, Chung UI, Sasaki N, Mochizuki M. Comparison of the long-term effects on rabbit bone defects between Tetrabone and ß-tricalcium phosphate granules implantation. J Artif Organs. 2014 Dec; 17(4):344-51. PMID: 25116218.
    View in: PubMed
  15. Kanke K, Masaki H, Saito T, Komiyama Y, Hojo H, Nakauchi H, Lichtler AC, Takato T, Chung UI, Ohba S. Stepwise differentiation of pluripotent stem cells into osteoblasts using four small molecules under serum-free and feeder-free conditions. Stem Cell Reports. 2014 Jun 03; 2(6):751-60. PMID: 24936463; PMCID: PMC4050355.
  16. Ha BG, Yonezawa T, Son MJ, Woo JT, Ohba S, Chung UI, Yagasaki K. Antidiabetic effect of nepodin, a component of Rumex roots, and its modes of action in vitro and in vivo. Biofactors. 2014 Jul-Aug; 40(4):436-47. PMID: 24756979.
    View in: PubMed
  17. Honnami M, Choi S, Liu IL, Kamimura W, Taguchi T, Hojo H, Shimohata N, Ohba S, Koyama H, Nishimura R, Chung UI, Sasaki N, Mochizuki M. Bone regeneration by the combined use of tetrapod-shaped calcium phosphate granules with basic fibroblast growth factor-binding ion complex gel in canine segmental radial defects. J Vet Med Sci. 2014 Jul; 76(7):955-61. PMID: 24670963; PMCID: PMC4143656.
  18. Zhang X, Peterson KA, Liu XS, McMahon AP, Ohba S. Gene regulatory networks mediating canonical Wnt signal-directed control of pluripotency and differentiation in embryo stem cells. Stem Cells. 2013 Dec; 31(12):2667-79. PMID: 23505158; PMCID: PMC3830733.
  19. Ohba S, Chung UI, Tei Y. [Identification of osteogenic signal and the development of artificial bones]. Clin Calcium. 2013 Dec; 23(12):1723-9. PMID: 24292526.
    View in: PubMed
  20. Choi S, Liu IL, Yamamoto K, Honnami M, Sakai T, Ohba S, Echigo R, Suzuki S, Nishimura R, Chung UI, Sasaki N, Mochizuki M. Implantation of tetrapod-shaped granular artificial bones or ß-tricalcium phosphate granules in a canine large bone-defect model. J Vet Med Sci. 2014 Mar 01; 76(2):229-35. PMID: 24161964; PMCID: PMC3982820.
  21. Saito T, Yano F, Mori D, Ohba S, Hojo H, Otsu M, Eto K, Nakauchi H, Tanaka S, Chung UI, Kawaguchi H. Generation of Col2a1-EGFP iPS cells for monitoring chondrogenic differentiation. PLoS One. 2013; 8(9):e74137. PMID: 24066106; PMCID: PMC3774617.
  22. Honnami M, Choi S, Liu IL, Kamimura W, Taguchi T, Hojo H, Shimohata N, Ohba S, Koyama H, Nishimura R, Chung UI, Sasaki N, Mochizuki M. Repair of rabbit segmental femoral defects by using a combination of tetrapod-shaped calcium phosphate granules and basic fibroblast growth factor-binding ion complex gel. Biomaterials. 2013 Dec; 34(36):9056-62. PMID: 23981356.
    View in: PubMed
  23. Yano F, Hojo H, Ohba S, Saito T, Honnami M, Mochizuki M, Takato T, Kawaguchi H, Chung UI. Cell-sheet technology combined with a thienoindazole derivative small compound TD-198946 for cartilage regeneration. Biomaterials. 2013 Jul; 34(22):5581-7. PMID: 23623324.
    View in: PubMed
  24. Maeda Y, Hojo H, Shimohata N, Choi S, Yamamoto K, Takato T, Chung UI, Ohba S. Bone healing by sterilizable calcium phosphate tetrapods eluting osteogenic molecules. Biomaterials. 2013 Jul; 34(22):5530-7. PMID: 23623228.
    View in: PubMed
  25. Komiyama Y, Ohba S, Shimohata N, Nakajima K, Hojo H, Yano F, Takato T, Docheva D, Shukunami C, Hiraki Y, Chung UI. Tenomodulin expression in the periodontal ligament enhances cellular adhesion. PLoS One. 2013; 8(4):e60203. PMID: 23593173; PMCID: PMC3622668.
  26. Hojo H, Ohba S, Taniguchi K, Shirai M, Yano F, Saito T, Ikeda T, Nakajima K, Komiyama Y, Nakagata N, Suzuki K, Mishina Y, Yamada M, Konno T, Takato T, Kawaguchi H, Kambara H, Chung UI. Hedgehog-Gli activators direct osteo-chondrogenic function of bone morphogenetic protein toward osteogenesis in the perichondrium. J Biol Chem. 2013 Apr 05; 288(14):9924-32. PMID: 23423383; PMCID: PMC3617292.
  27. Wu S, Kasim V, Kano MR, Tanaka S, Ohba S, Miura Y, Miyata K, Liu X, Matsuhashi A, Chung UI, Yang L, Kataoka K, Nishiyama N, Miyagishi M. Transcription factor YY1 contributes to tumor growth by stabilizing hypoxia factor HIF-1a in a p53-independent manner. Cancer Res. 2013 Mar 15; 73(6):1787-99. PMID: 23328582.
    View in: PubMed
  28. Ogasawara T, Ohba S, Yano F, Kawaguchi H, Chung UI, Saito T, Yonehara Y, Nakatsuka T, Mori Y, Takato T, Hoshi K. Nanog promotes osteogenic differentiation of the mouse mesenchymal cell line C3H10T1/2 by modulating bone morphogenetic protein (BMP) signaling. J Cell Physiol. 2013 Jan; 228(1):163-71. PMID: 22585661.
    View in: PubMed
  29. Ohba S, Hojo H, Chung UI. Bioactive factors for tissue regeneration: state of the art. Muscles Ligaments Tendons J. 2012 Jul; 2(3):193-203. PMID: 23738297; PMCID: PMC3666524.
  30. Yano F, Hojo H, Ohba S, Fukai A, Hosaka Y, Ikeda T, Saito T, Hirata M, Chikuda H, Takato T, Kawaguchi H, Chung UI. A novel disease-modifying osteoarthritis drug candidate targeting Runx1. Ann Rheum Dis. 2013 May; 72(5):748-53. PMID: 23041841.
    View in: PubMed
  31. Yamamoto K, Hojo H, Koshima I, Chung UI, Ohba S. Famotidine suppresses osteogenic differentiation of tendon cells in vitro and pathological calcification of tendon in vivo. J Orthop Res. 2012 Dec; 30(12):1958-62. PMID: 22592911.
    View in: PubMed
  32. Hojo H, Ohba S, Yano F, Saito T, Ikeda T, Nakajima K, Komiyama Y, Nakagata N, Suzuki K, Takato T, Kawaguchi H, Chung UI. Gli1 protein participates in Hedgehog-mediated specification of osteoblast lineage during endochondral ossification. J Biol Chem. 2012 May 18; 287(21):17860-9. PMID: 22493482; PMCID: PMC3366782.
  33. Hojo H, Ohba S, Yano F, Chung UI. Coordination of chondrogenesis and osteogenesis by hypertrophic chondrocytes in endochondral bone development. J Bone Miner Metab. 2010 Sep; 28(5):489-502. PMID: 20607327.
    View in: PubMed
  34. Saito T, Fukai A, Mabuchi A, Ikeda T, Yano F, Ohba S, Nishida N, Akune T, Yoshimura N, Nakagawa T, Nakamura K, Tokunaga K, Chung UI, Kawaguchi H. Transcriptional regulation of endochondral ossification by HIF-2alpha during skeletal growth and osteoarthritis development. Nat Med. 2010 Jun; 16(6):678-86. PMID: 20495570.
    View in: PubMed
  35. Nakajima K, Komiyama Y, Hojo H, Ohba S, Yano F, Nishikawa N, Ihara S, Aburatani H, Takato T, Chung UI. Enhancement of bone formation ex vivo and in vivo by a helioxanthin-derivative. Biochem Biophys Res Commun. 2010 May 14; 395(4):502-8. PMID: 20382113.
    View in: PubMed
  36. Hojo H, Yano F, Ohba S, Igawa K, Nakajima K, Komiyama Y, Kan A, Ikeda T, Yonezawa T, Woo JT, Takato T, Nakamura K, Kawaguchi H, Chung UI. Identification of oxytetracycline as a chondrogenic compound using a cell-based screening system. J Bone Miner Metab. 2010 Nov; 28(6):627-33. PMID: 20376510.
    View in: PubMed
  37. Zhao J, Ohba S, Komiyama Y, Shinkai M, Chung UI, Nagamune T. Icariin: a potential osteoinductive compound for bone tissue engineering. Tissue Eng Part A. 2010 Jan; 16(1):233-43. PMID: 19698057.
    View in: PubMed
  38. Zhao J, Shinkai M, Takezawa T, Ohba S, Chung UI, Nagamune T. Bone regeneration using collagen type I vitrigel with bone morphogenetic protein-2. J Biosci Bioeng. 2009 Mar; 107(3):318-23. PMID: 19269600.
    View in: PubMed
  39. Hirata M, Kugimiya F, Fukai A, Ohba S, Kawamura N, Ogasawara T, Kawasaki Y, Saito T, Yano F, Ikeda T, Nakamura K, Chung UI, Kawaguchi H. C/EBPbeta Promotes transition from proliferation to hypertrophic differentiation of chondrocytes through transactivation of p57. PLoS One. 2009; 4(2):e4543. PMID: 19229324; PMCID: PMC2638010.
  40. Wang W, Itaka K, Ohba S, Nishiyama N, Chung UI, Yamasaki Y, Kataoka K. 3D spheroid culture system on micropatterned substrates for improved differentiation efficiency of multipotent mesenchymal stem cells. Biomaterials. 2009 May; 30(14):2705-15. PMID: 19215979.
    View in: PubMed
  41. Higashikawa A, Saito T, Ikeda T, Kamekura S, Kawamura N, Kan A, Oshima Y, Ohba S, Ogata N, Takeshita K, Nakamura K, Chung UI, Kawaguchi H. Identification of the core element responsive to runt-related transcription factor 2 in the promoter of human type X collagen gene. Arthritis Rheum. 2009 Jan; 60(1):166-78. PMID: 19116917.
    View in: PubMed
  42. Ogata N, Chung UI, Tei Y, Ohba S, Kawaguchi H. [Optimization of signaling pathways for bone regeneration]. Clin Calcium. 2008 Dec; 18(12):1707-12. PMID: 19043183.
    View in: PubMed
  43. Hojo H, Igawa K, Ohba S, Yano F, Nakajima K, Komiyama Y, Ikeda T, Lichtler AC, Woo JT, Yonezawa T, Takato T, Chung UI. Development of high-throughput screening system for osteogenic drugs using a cell-based sensor. Biochem Biophys Res Commun. 2008 Nov 14; 376(2):375-9. PMID: 18789892.
    View in: PubMed
  44. Ohba S, Kawaguchi H, Kugimiya F, Ogasawara T, Kawamura N, Saito T, Ikeda T, Fujii K, Miyajima T, Kuramochi A, Miyashita T, Oda H, Nakamura K, Takato T, Chung UI. Patched1 haploinsufficiency increases adult bone mass and modulates Gli3 repressor activity. Dev Cell. 2008 May; 14(5):689-99. PMID: 18477452.
    View in: PubMed
  45. Tamiya H, Ikeda T, Jeong JH, Saito T, Yano F, Jung YK, Ohba S, Kawaguchi H, Chung UI, Choi JY. Analysis of the Runx2 promoter in osseous and non-osseous cells and identification of HIF2A as a potent transcription activator. Gene. 2008 Jun 15; 416(1-2):53-60. PMID: 18442887.
    View in: PubMed
  46. Zhao J, Ohba S, Shinkai M, Chung UI, Nagamune T. Icariin induces osteogenic differentiation in vitro in a BMP- and Runx2-dependent manner. Biochem Biophys Res Commun. 2008 May 02; 369(2):444-8. PMID: 18295595.
    View in: PubMed
  47. Ohba S, Chung UI, Tei Y. [Osteoblast differentiation induced by BMP signaling and Runx2 through Cbfb regulation]. Nihon Rinsho. 2007 Nov 28; 65 Suppl 9:71-4. PMID: 18161084.
    View in: PubMed
  48. Kawamura N, Kugimiya F, Oshima Y, Ohba S, Ikeda T, Saito T, Shinoda Y, Kawasaki Y, Ogata N, Hoshi K, Akiyama T, Chen WS, Hay N, Tobe K, Kadowaki T, Azuma Y, Tanaka S, Nakamura K, Chung UI, Kawaguchi H. Akt1 in osteoblasts and osteoclasts controls bone remodeling. PLoS One. 2007 Oct 24; 2(10):e1058. PMID: 17957242; PMCID: PMC2020440.
  49. Kugimiya F, Kawaguchi H, Ohba S, Kawamura N, Hirata M, Chikuda H, Azuma Y, Woodgett JR, Nakamura K, Chung UI. GSK-3beta controls osteogenesis through regulating Runx2 activity. PLoS One. 2007 Sep 05; 2(9):e837. PMID: 17786208; PMCID: PMC1950686.
  50. Itaka K, Ohba S, Miyata K, Kawaguchi H, Nakamura K, Takato T, Chung UI, Kataoka K. Bone regeneration by regulated in vivo gene transfer using biocompatible polyplex nanomicelles. Mol Ther. 2007 Sep; 15(9):1655-62. PMID: 17551504.
    View in: PubMed
  51. Ohba S, Nakajima K, Komiyama Y, Kugimiya F, Igawa K, Itaka K, Moro T, Nakamura K, Kawaguchi H, Takato T, Chung UI. A novel osteogenic helioxanthin-derivative acts in a BMP-dependent manner. Biochem Biophys Res Commun. 2007 Jun 15; 357(4):854-60. PMID: 17451649.
    View in: PubMed
  52. Ohba S, Ikeda T, Kugimiya F, Yano F, Lichtler AC, Nakamura K, Takato T, Kawaguchi H, Chung UI. Identification of a potent combination of osteogenic genes for bone regeneration using embryonic stem (ES) cell-based sensor. FASEB J. 2007 Jun; 21(8):1777-87. PMID: 17317722.
    View in: PubMed
  53. Kugimiya F, Ohba S, Nakamura K, Kawaguchi H, Chung UI. Physiological role of bone morphogenetic proteins in osteogenesis. J Bone Miner Metab. 2006; 24(2):95-9. PMID: 16502114.
    View in: PubMed
  54. Kugimiya F, Yano F, Ohba S, Igawa K, Nakamura K, Kawaguchi H, Chung UI. Mechanism of osteogenic induction by FK506 via BMP/Smad pathways. Biochem Biophys Res Commun. 2005 Dec 16; 338(2):872-9. PMID: 16246307.
    View in: PubMed
  55. Kugimiya F, Kawaguchi H, Kamekura S, Chikuda H, Ohba S, Yano F, Ogata N, Katagiri T, Harada Y, Azuma Y, Nakamura K, Chung UI. Involvement of endogenous bone morphogenetic protein (BMP) 2 and BMP6 in bone formation. J Biol Chem. 2005 Oct 21; 280(42):35704-12. PMID: 16109715.
    View in: PubMed
  56. Yano F, Kugimiya F, Ohba S, Ikeda T, Chikuda H, Ogasawara T, Ogata N, Takato T, Nakamura K, Kawaguchi H, Chung UI. The canonical Wnt signaling pathway promotes chondrocyte differentiation in a Sox9-dependent manner. Biochem Biophys Res Commun. 2005 Aug 12; 333(4):1300-8. PMID: 15979579.
    View in: PubMed
  57. Kawaguchi H, Akune T, Yamaguchi M, Ohba S, Ogata N, Chung UI, Kubota N, Terauchi Y, Kadowaki T, Nakamura K. Distinct effects of PPARgamma insufficiency on bone marrow cells, osteoblasts, and osteoclastic cells. J Bone Miner Metab. 2005; 23(4):275-9. PMID: 15981022.
    View in: PubMed
  58. Ohba S, Igawa K, Nakamura K, Kawaguchi H, Takato T, Chung UI. [Regenerative medicine of bone and cartilage]. Nihon Ronen Igakkai Zasshi. 2004 Nov; 41(6):582-8. PMID: 15651365.
    View in: PubMed
  59. Akune T, Ohba S, Kamekura S, Yamaguchi M, Chung UI, Kubota N, Terauchi Y, Harada Y, Azuma Y, Nakamura K, Kadowaki T, Kawaguchi H. PPARgamma insufficiency enhances osteogenesis through osteoblast formation from bone marrow progenitors. J Clin Invest. 2004 Mar; 113(6):846-55. PMID: 15067317; PMCID: PMC362117.
  60. Long F, Chung UI, Ohba S, McMahon J, Kronenberg HM, McMahon AP. Ihh signaling is directly required for the osteoblast lineage in the endochondral skeleton. Development. 2004 Mar; 131(6):1309-18. PMID: 14973297.
    View in: PubMed
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