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Tanya Maria Laidlaw, M.D.

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Overview
Our research is focused on understanding Aspirin Exacerbated Respiratory Disease (AERD), also known as Aspirin Sensitive Asthma or Samter’s Triad. We are investigating the causative mechanisms of AERD/Samter’s Triad, as well as exploring new treatments for the disease and working to understand how patients can become desensitized to aspirin. Our group at the Brigham and Women’s Hospital’s AERD Center follows over 900 patients with AERD/Samter’s Triad and have several ongoing research studies that are currently recruiting and enrolling patients.

We are also actively involved in research to further knowledge about the causes of chronic rhinosinusitis and nasal polyps, and to better understand the consequences of being allergic to aspirin or NSAIDs.

Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01HL128241 (LAIDLAW, TANYA MARIA) Aug 15, 2015 - May 31, 2020
    NIH/NHLBI
    Prostaglandin D2: A Key Mediator of Aspirin-Exacerbated Respiratory Disease
    Role: Principal Investigator
  2. K23HL111113 (LAIDLAW, TANYA MARIA) Aug 15, 2012 - Jul 31, 2017
    NIH/NHLBI
    The inflammatory role of the platelet in aspirin-exacerbated respiratory disease.
    Role: Principal Investigator

Featured Content

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Huang GX, Palumbo ML, Singer JI, Cahill KN, Laidlaw TM. Sinus surgery improves lower respiratory reactivity during aspirin desensitization for AERD. J Allergy Clin Immunol Pract. 2019 Mar 12. PMID: 30877073.
    Citations:    
  2. Liu T, Barrett NA, Kanaoka Y, Buchheit K, Laidlaw TM, Garofalo D, Lai J, Katz HR, Feng C, Boyce JA. Cysteinyl leukotriene receptor 2 drives lung immunopathology through a platelet and high mobility box 1-dependent mechanism. Mucosal Immunol. 2019 Jan 21. PMID: 30664709.
    Citations:    Fields:    
  3. Laidlaw TM. Clinical updates in aspirin-exacerbated respiratory disease. Allergy Asthma Proc. 2019 Jan 01; 40(1):4-6. PMID: 30582489.
    Citations:    Fields:    
  4. Kiladejo A, Palumbo M, Laidlaw TM. Accidental ingestion of aspirin and nonsteroidal anti-inflammatory drugs is common in patients with aspirin-exacerbated respiratory disease. J Allergy Clin Immunol Pract. 2018 Nov 24. PMID: 30481585.
    Citations:    Fields:    
  5. DeGregorio GA, Singer J, Cahill KN, Laidlaw T. A 1-Day, 90-Minute Aspirin Challenge and Desensitization Protocol in Aspirin-Exacerbated Respiratory Disease. J Allergy Clin Immunol Pract. 2018 Nov 02. PMID: 30391549.
    Citations:    Fields:    
  6. Cahill KN, Murphy K, Singer J, Israel E, Boyce JA, Laidlaw TM. Plasma tryptase elevation during aspirin-induced reactions in aspirin-exacerbated respiratory disease. J Allergy Clin Immunol. 2019 Feb; 143(2):799-803.e2. PMID: 30339852.
    Citations:    Fields:    
  7. Laidlaw TM, Prussin C, Panettieri RA, Lee S, Ferguson BJ, Adappa ND, Lane AP, Palumbo ML, Sullivan M, Archibald D, Dworetzky SI, Hebrank GT, Bozik ME. Dexpramipexole depletes blood and tissue eosinophils in nasal polyps with no change in polyp size. Laryngoscope. 2019 Feb; 129(2):E61-E66. PMID: 30284267.
    Citations:    Fields:    
  8. Kowalski ML, Agache I, Bavbek S, Bakirtas A, Blanca M, Bochenek G, Bonini M, Heffler E, Klimek L, Laidlaw TM, Mullol J, Nizankowska-Mogilnicka E, Park HS, Sanak M, Sanchez-Borges M, Sanchez-Garcia S, Scadding G, Taniguchi M, Torres MJ, White AA, Wardzynska A. Diagnosis and management of NSAID-Exacerbated Respiratory Disease (N-ERD)-a EAACI position paper. Allergy. 2019 Jan; 74(1):28-39. PMID: 30216468.
    Citations:    Fields:    
  9. Eid RC, Palumbo ML, Laidlaw TM, Buchheit KM, Cahill KN. A retrospective analysis of esophageal eosinophilia in patients with aspirin-exacerbated respiratory disease. J Allergy Clin Immunol Pract. 2018 Sep 25. PMID: 30261317.
    Citations:    Fields:    
  10. Ordovas-Montanes J, Dwyer DF, Nyquist SK, Buchheit KM, Vukovic M, Deb C, Wadsworth MH, Hughes TK, Kazer SW, Yoshimoto E, Cahill KN, Bhattacharyya N, Katz HR, Berger B, Laidlaw TM, Boyce JA, Barrett NA, Shalek AK. Allergic inflammatory memory in human respiratory epithelial progenitor cells. Nature. 2018 08; 560(7720):649-654. PMID: 30135581.
    Citations:    Fields:    
  11. Laidlaw TM, Cahill KN, Cardet JC, Murphy K, Cui J, Dioneda B, Kothari P, Raby BA, Israel E, Boyce JA. A trial of type 12 purinergic (P2Y12) receptor inhibition with prasugrel identifies a potentially distinct endotype of patients with aspirin-exacerbated respiratory disease. J Allergy Clin Immunol. 2019 Jan; 143(1):316-324.e7. PMID: 29890239.
    Citations:    Fields:    
  12. Tuttle KL, Buchheit KM, Laidlaw TM, Cahill KN. A retrospective analysis of mepolizumab in subjects with aspirin-exacerbated respiratory disease. J Allergy Clin Immunol Pract. 2018 May - Jun; 6(3):1045-1047. PMID: 29501519.
    Citations: 1     Fields:    
  13. Schneider TR, Johns CB, Palumbo ML, Murphy KC, Cahill KN, Laidlaw TM. Dietary Fatty Acid Modification for the Treatment of Aspirin-Exacerbated Respiratory Disease: A Prospective Pilot Trial. J Allergy Clin Immunol Pract. 2018 May - Jun; 6(3):825-831. PMID: 29133219.
    Citations:    Fields:    
  14. Laidlaw TM. Expanding our research horizons. Am J Rhinol Allergy. 2017 Sep 01; 31(5):281-282. PMID: 28859700.
    Citations:    
  15. Cahill KN, Katz HR, Cui J, Lai J, Kazani S, Crosby-Thompson A, Garofalo D, Castro M, Jarjour N, DiMango E, Erzurum S, Trevor JL, Shenoy K, Chinchilli VM, Wechsler ME, Laidlaw TM, Boyce JA, Israel E. KIT Inhibition by Imatinib in Patients with Severe Refractory Asthma. N Engl J Med. 2017 05 18; 376(20):1911-1920. PMID: 28514613.
    Citations: 8     Fields:    Translation:HumansCells
  16. Laidlaw TM, Cahill KN. Current Knowledge and Management of Hypersensitivity to Aspirin and NSAIDs. J Allergy Clin Immunol Pract. 2017 May - Jun; 5(3):537-545. PMID: 28483309.
    Citations:    Fields:    Translation:HumansAnimalsPHPublic Health
  17. Hagan JB, Laidlaw TM, Divekar R, O'Brien EK, Kita H, Volcheck GW, Hagan CR, Lal D, Teaford HG, Erwin PJ, Zhang N, Rank MA. Urinary Leukotriene E4 to Determine Aspirin Intolerance in Asthma: A Systematic Review and Meta-Analysis. J Allergy Clin Immunol Pract. 2017 Jul - Aug; 5(4):990-997.e1. PMID: 28202405.
    Citations: 1     Fields:    Translation:Humans
  18. Cahill KN, Laidlaw TM. Pathogenesis of Aspirin-Induced Reactions in Aspirin-Exacerbated Respiratory Disease. Immunol Allergy Clin North Am. 2016 11; 36(4):681-691. PMID: 27712763.
    Citations: 1     Fields:    Translation:Humans
  19. Cahill KN, Johns CB, Cui J, Wickner P, Bates DW, Laidlaw TM, Beeler PE. Automated identification of an aspirin-exacerbated respiratory disease cohort. J Allergy Clin Immunol. 2017 Mar; 139(3):819-825.e6. PMID: 27567328.
    Citations: 2     Fields:    Translation:Humans
  20. Shah NH, Schneider TR, DeFaria Yeh D, Cahill KN, Laidlaw TM. Eosinophilia-Associated Coronary Artery Vasospasm in Patients with Aspirin-Exacerbated Respiratory Disease. J Allergy Clin Immunol Pract. 2016 Nov - Dec; 4(6):1215-1219. PMID: 27396680.
    Citations:    Fields:    Translation:Humans
  21. Tuttle KL, Schneider TR, Henrickson SE, Morris D, Abonia JP, Spergel JM, Laidlaw TM. Aspirin-exacerbated respiratory disease: not always "adult-onset". J Allergy Clin Immunol Pract. 2016 Jul-Aug; 4(4):756-8. PMID: 27393784.
    Citations: 1     Fields:    Translation:Humans
  22. Buchheit KM, Laidlaw TM. Update on the Management of Aspirin-Exacerbated Respiratory Disease. Allergy Asthma Immunol Res. 2016 Jul; 8(4):298-304. PMID: 27126722; PMCID: PMC4853506.
    Citations: 5     
  23. Yamaguchi M, Zacharia J, Laidlaw TM, Balestrieri B. PLA2G5 regulates transglutaminase activity of human IL-4-activated M2 macrophages through PGE2 generation. J Leukoc Biol. 2016 07; 100(1):131-41. PMID: 26936936; PMCID: PMC4946619.
    Citations: 4     Fields:    Translation:HumansCells
  24. Sloane D, Govindarajulu U, Harrow-Mortelliti J, Barry W, Hsu FI, Hong D, Laidlaw T, Palis R, Legere H, Bunyavanich S, Breslow R, Wesemann D, Barrett N, Brennan P, Chong HJ, Liu A, Fernandez J, Fanning L, Kyin T, Cahill K, Bankova L, Lynch A, Berlin S, Campos S, Fuchs C, Mayer R, Matulonis U, Castells M. Safety, Costs, and Efficacy of Rapid Drug Desensitizations to Chemotherapy and Monoclonal Antibodies. J Allergy Clin Immunol Pract. 2016 May-Jun; 4(3):497-504. PMID: 26895621.
    Citations: 5     Fields:    Translation:Humans
  25. Laidlaw TM, Boyce JA. Aspirin-Exacerbated Respiratory Disease--New Prime Suspects. N Engl J Med. 2016 Feb 04; 374(5):484-8. PMID: 26840139.
    Citations: 15     Fields:    Translation:Humans
  26. Cahill KN, Raby BA, Zhou X, Guo F, Thibault D, Baccarelli A, Byun HM, Bhattacharyya N, Steinke JW, Boyce JA, Laidlaw TM. Impaired E Prostanoid2 Expression and Resistance to Prostaglandin E2 in Nasal Polyp Fibroblasts from Subjects with Aspirin-Exacerbated Respiratory Disease. Am J Respir Cell Mol Biol. 2016 Jan; 54(1):34-40. PMID: 26051534; PMCID: PMC4742927.
    Citations: 9     Fields:    Translation:HumansCells
  27. Buchheit KM, Cahill KN, Katz HR, Murphy KC, Feng C, Lee-Sarwar K, Lai J, Bhattacharyya N, Israel E, Boyce JA, Laidlaw TM. Thymic stromal lymphopoietin controls prostaglandin D2 generation in patients with aspirin-exacerbated respiratory disease. J Allergy Clin Immunol. 2016 05; 137(5):1566-1576.e5. PMID: 26691435.
    Citations: 15     Fields:    Translation:HumansCells
  28. Liu T, Kanaoka Y, Barrett NA, Feng C, Garofalo D, Lai J, Buchheit K, Bhattacharya N, Laidlaw TM, Katz HR, Boyce JA. Aspirin-Exacerbated Respiratory Disease Involves a Cysteinyl Leukotriene-Driven IL-33-Mediated Mast Cell Activation Pathway. J Immunol. 2015 Oct 15; 195(8):3537-45. PMID: 26342029; PMCID: PMC4592820.
    Citations: 14     Fields:    Translation:HumansAnimalsCellsCTClinical Trials
  29. Laidlaw TM. How Patient Experiences Should Change Our Approach to Treating Patients with Aspirin-Exacerbated Respiratory Disease. J Allergy Clin Immunol Pract. 2015 Sep-Oct; 3(5):719-20. PMID: 26362552.
    Citations: 1     Fields:    Translation:Humans
  30. Laidlaw TM, Boyce JA. Platelets in patients with aspirin-exacerbated respiratory disease. J Allergy Clin Immunol. 2015 Jun; 135(6):1407-14; quiz 1415. PMID: 26051947; PMCID: PMC4559084.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  31. Liu T, Garofalo D, Feng C, Lai J, Katz H, Laidlaw TM, Boyce JA. Platelet-driven leukotriene C4-mediated airway inflammation in mice is aspirin-sensitive and depends on T prostanoid receptors. J Immunol. 2015 Jun 01; 194(11):5061-8. PMID: 25904552; PMCID: PMC4433852.
    Citations: 2     Fields:    Translation:AnimalsCells
  32. Lee-Sarwar K, Johns C, Laidlaw TM, Cahill KN. Tolerance of daily low-dose aspirin does not preclude aspirin-exacerbated respiratory disease. J Allergy Clin Immunol Pract. 2015 May-Jun; 3(3):449-51. PMID: 25634222.
    Citations: 4     Fields:    Translation:Humans
  33. Cahill KN, Laidlaw TM. Aspirin exacerbated respiratory disease: the search for a biomarker. Ann Allergy Asthma Immunol. 2014 Nov; 113(5):500-1. PMID: 25442693.
    Citations: 4     Fields:    Translation:Humans
  34. Cahill KN, Bensko JC, Boyce JA, Laidlaw TM. Prostaglandin D2: a dominant mediator of aspirin-exacerbated respiratory disease. J Allergy Clin Immunol. 2015 Jan; 135(1):245-52. PMID: 25218285.
    Citations: 27     Fields:    Translation:HumansCells
  35. Johns CB, Laidlaw TM. Elevated total serum IgE in nonatopic patients with aspirin-exacerbated respiratory disease. Am J Rhinol Allergy. 2014 Jul-Aug; 28(4):287-9. PMID: 25197914.
    Citations: 7     Fields:    Translation:Humans
  36. Cardet JC, White AA, Barrett NA, Feldweg AM, Wickner PG, Savage J, Bhattacharyya N, Laidlaw TM. Alcohol-induced respiratory symptoms are common in patients with aspirin exacerbated respiratory disease. J Allergy Clin Immunol Pract. 2014 Mar-Apr; 2(2):208-13.. PMID: 24607050; PMCID: PMC4018190.
    Citations: 7     Fields:    Translation:Humans
  37. Laidlaw TM, Cutler AJ, Kidder MS, Liu T, Cardet JC, Chhay H, Feng C, Boyce JA. Prostaglandin E2 resistance in granulocytes from patients with aspirin-exacerbated respiratory disease. J Allergy Clin Immunol. 2014 Jun; 133(6):1692-701.e3. PMID: 24486071.
    Citations: 10     Fields:    Translation:HumansCells
  38. Cummings HE, Liu T, Feng C, Laidlaw TM, Conley PB, Kanaoka Y, Boyce JA. Cutting edge: Leukotriene C4 activates mouse platelets in plasma exclusively through the type 2 cysteinyl leukotriene receptor. J Immunol. 2013 Dec 15; 191(12):5807-10. PMID: 24244016; PMCID: PMC3869987.
    Citations: 9     Fields:    Translation:AnimalsCells
  39. Liu T, Laidlaw TM, Katz HR, Boyce JA. Prostaglandin E2 deficiency causes a phenotype of aspirin sensitivity that depends on platelets and cysteinyl leukotrienes. Proc Natl Acad Sci U S A. 2013 Oct 15; 110(42):16987-92. PMID: 24085850; PMCID: PMC3801005.
    Citations: 30     Fields:    Translation:HumansAnimalsCells
  40. Laidlaw TM, Boyce JA. Pathogenesis of aspirin-exacerbated respiratory disease and reactions. Immunol Allergy Clin North Am. 2013 May; 33(2):195-210. PMID: 23639708; PMCID: PMC3781366.
    Citations: 18     Fields:    Translation:HumansAnimalsCells
  41. Laidlaw TM, Boyce JA. Cysteinyl leukotriene receptors, old and new; implications for asthma. Clin Exp Allergy. 2012 Sep; 42(9):1313-20. PMID: 22925317; PMCID: PMC3773244.
    Citations: 20     Fields:    Translation:HumansAnimalsCells
  42. Liu T, Laidlaw TM, Feng C, Xing W, Shen S, Milne GL, Boyce JA. Prostaglandin E2 deficiency uncovers a dominant role for thromboxane A2 in house dust mite-induced allergic pulmonary inflammation. Proc Natl Acad Sci U S A. 2012 Jul 31; 109(31):12692-7. PMID: 22802632; PMCID: PMC3411985.
    Citations: 21     Fields:    Translation:AnimalsCells
  43. Laidlaw TM, Kidder MS, Bhattacharyya N, Xing W, Shen S, Milne GL, Castells MC, Chhay H, Boyce JA. Cysteinyl leukotriene overproduction in aspirin-exacerbated respiratory disease is driven by platelet-adherent leukocytes. Blood. 2012 Apr 19; 119(16):3790-8. PMID: 22262771; PMCID: PMC3335383.
    Citations: 48     Fields:    Translation:HumansCells
  44. Laidlaw TM, Steinke JW, Tiñana AM, Feng C, Xing W, Lam BK, Paruchuri S, Boyce JA, Borish L. Characterization of a novel human mast cell line that responds to stem cell factor and expresses functional FceRI. J Allergy Clin Immunol. 2011 Mar; 127(3):815-22.e1-5. PMID: 21281958; PMCID: PMC3052637.
    Citations: 13     Fields:    Translation:HumansCells
  45. He P, Laidlaw T, Maekawa A, Kanaoka Y, Xu K, Lam BK. Oxidative stress suppresses cysteinyl leukotriene generation by mouse bone marrow-derived mast cells. J Biol Chem. 2011 Mar 11; 286(10):8277-86. PMID: 21233206; PMCID: PMC3048713.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  46. Andrew A. White, Tanya M. Laidlaw, Katherine Woessner. Anaphylaxis and Hypersensitivity Reactions; M.C. Castells (Ed.). Aspirin and NSAID Reactions: Diagnosis, Pathophysiology, and Management. 2011; 107-126.
  47. Lundequist A, Nallamshetty SN, Xing W, Feng C, Laidlaw TM, Uematsu S, Akira S, Boyce JA. Prostaglandin E(2) exerts homeostatic regulation of pulmonary vascular remodeling in allergic airway inflammation. J Immunol. 2010 Jan 01; 184(1):433-41. PMID: 20028661; PMCID: PMC3721536.
    Citations: 24     Fields:    Translation:Animals
  48. TM Laidlaw, BA Markens, L Borish, JA Boyce. American Academy of Allergy, Asthma & Immunology national meeting, 2009. Peripheral Blood Cyclooxygenase (COX) Deficiency in Aspirin Exacerbated Respiratory Disease (AERD) and Regulation of Eicosanoid Enzymes by Aspirin Desensitization. 2009.
  49. Castells MC, Tennant NM, Sloane DE, Hsu FI, Barrett NA, Hong DI, Laidlaw TM, Legere HJ, Nallamshetty SN, Palis RI, Rao JJ, Berlin ST, Campos SM, Matulonis UA. Hypersensitivity reactions to chemotherapy: outcomes and safety of rapid desensitization in 413 cases. J Allergy Clin Immunol. 2008 Sep; 122(3):574-80. PMID: 18502492.
    Citations: 43     Fields:    Translation:Humans
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Funded by the NIH/NCATS Clinical and Translational Science Award (CTSA) program, grant number UL1TR001102, and through institutional support from Harvard University, Harvard Medical School, Harvard T.H. Chan School of Public Health, Beth Israel Deaconess Medical Center, Boston Children's Hospital, Brigham and Women's Hospital, Massachusetts General Hospital and the Dana Farber Cancer Institute.