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Tanya Maria Laidlaw, M.D.

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Overview
Our research is focused on understanding Aspirin Exacerbated Respiratory Disease (AERD), also known as Aspirin Sensitive Asthma or Samter’s Triad. We are investigating the causative mechanisms of AERD/Samter’s Triad, as well as exploring new treatments for the disease and working to understand how patients can become desensitized to aspirin. Our group at the Brigham and Women’s Hospital’s AERD Center follows over 900 patients with AERD/Samter’s Triad and have several ongoing research studies that are currently recruiting and enrolling patients.

We are also actively involved in research to further knowledge about the causes of chronic rhinosinusitis and nasal polyps, and to better understand the consequences of being allergic to aspirin or NSAIDs.

Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01HL128241 (LAIDLAW, TANYA MARIA) Aug 15, 2015 - May 31, 2020
    NIH/NHLBI
    Prostaglandin D2: A Key Mediator of Aspirin-Exacerbated Respiratory Disease
    Role: Principal Investigator
  2. K23HL111113 (LAIDLAW, TANYA MARIA) Aug 15, 2012 - Jul 31, 2017
    NIH/NHLBI
    The inflammatory role of the platelet in aspirin-exacerbated respiratory disease.
    Role: Principal Investigator

Featured Content

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Laidlaw TM. Aspirin desensitization vs biologics for patients with aspirin-exacerbated respiratory disease. Ann Allergy Asthma Immunol. 2020 Aug 07. PMID: 32771353.
    Citations:    
  2. Alanin MC, Laidlaw T, Society TS, Hopkins C. The Burden of Non-steroidal anti-inflammatory exacerbated respiratory disease from the patient's perspective - a qualitative analysis of posts from the Samter's Society. Rhinology. 2020 Aug 01; 58(4):333-340. PMID: 32219224.
    Citations:    
  3. Laidlaw TM, Gakpo DH, Bensko JC, Buchheit K. Leukotriene-Associated Rash in Aspirin-Exacerbated Respiratory Disease. J Allergy Clin Immunol Pract. 2020 Jul 29. PMID: 32739465.
    Citations:    
  4. Roland LT, Smith TL, Schlosser RJ, Soler ZM, Peters AT, Laidlaw TM, Bleier BS, Ramakrishnan V, Toskala E, Kennedy DW, Luong AU. Guidance for contemporary use of biologics in management of chronic rhinosinusitis with nasal polyps: discussion from a National Institutes of Health-sponsored workshop. Int Forum Allergy Rhinol. 2020 Sep; 10(9):1037-1042. PMID: 32484603.
    Citations:    
  5. Mullur J, Laidlaw TM. Aspirin allergy labeling after desensitization: education, communication, and patient safety. J Allergy Clin Immunol Pract. 2020 Jun 22. PMID: 32585406.
    Citations:    
  6. Lal D, Borish L, Detwiller KY, Gray ST, Joshi S, Kern RC, Laidlaw TM, Marino MJ, Payne SC, Peters AT, Soler ZM, Rank MA. A case for multidisciplinary management of chronic rhinosinusitis with nasal polyposis. Int Forum Allergy Rhinol. 2020 Jul; 10(7):795-797. PMID: 32362073.
    Citations:    
  7. Cho SH, Hamilos DL, Han DH, Laidlaw TM. Phenotypes of Chronic Rhinosinusitis. J Allergy Clin Immunol Pract. 2020 May; 8(5):1505-1511. PMID: 32389275.
    Citations:    
  8. Ziegler CGK, Allon SJ, Nyquist SK, Mbano IM, Miao VN, Tzouanas CN, Cao Y, Yousif AS, Bals J, Hauser BM, Feldman J, Muus C, Wadsworth MH, Kazer SW, Hughes TK, Doran B, Gatter GJ, Vukovic M, Taliaferro F, Mead BE, Guo Z, Wang JP, Gras D, Plaisant M, Ansari M, Angelidis I, Adler H, Sucre JMS, Taylor CJ, Lin B, Waghray A, Mitsialis V, Dwyer DF, Buchheit KM, Boyce JA, Barrett NA, Laidlaw TM, Carroll SL, Colonna L, Tkachev V, Peterson CW, Yu A, Zheng HB, Gideon HP, Winchell CG, Lin PL, Bingle CD, Snapper SB, Kropski JA, Theis FJ, Schiller HB, Zaragosi LE, Barbry P, Leslie A, Kiem HP, Flynn JL, Fortune SM, Berger B, Finberg RW, Kean LS, Garber M, Schmidt AG, Lingwood D, Shalek AK, Ordovas-Montanes J. SARS-CoV-2 Receptor ACE2 Is an Interferon-Stimulated Gene in Human Airway Epithelial Cells and Is Detected in Specific Cell Subsets across Tissues. Cell. 2020 05 28; 181(5):1016-1035.e19. PMID: 32413319.
    Citations:    
  9. Chen YS, Bensko JC, Laidlaw TM, Buchheit KM. A retrospective analysis of bronchiectasis in patients with aspirin-exacerbated respiratory disease. J Allergy Clin Immunol Pract. 2020 Sep; 8(8):2799-2801. PMID: 32330669.
    Citations:    
  10. Buchheit KM, Dwyer DF, Ordovas-Montanes J, Katz HR, Lewis E, Vukovic M, Lai J, Bankova LG, Bhattacharyya N, Shalek AK, Barrett NA, Boyce JA, Laidlaw TM. IL-5Ra marks nasal polyp IgG4- and IgE-expressing cells in aspirin-exacerbated respiratory disease. J Allergy Clin Immunol. 2020 Jun; 145(6):1574-1584. PMID: 32199912.
    Citations:    
  11. Laidlaw TM, Levy JM. NSAID-ERD Syndrome: the New Hope from Prevention, Early Diagnosis, and New Therapeutic Targets. Curr Allergy Asthma Rep. 2020 Mar 14; 20(4):10. PMID: 32172365.
    Citations:    
  12. Lal D, Borish L, Detwiller KY, Gray ST, Joshi S, Kern RC, Laidlaw TM, Marino MJ, Payne SC, Peters AT, Soler ZM, Rank MA. The Rationale for Multidisciplinary Management of Chronic Rhinosinusitis with Nasal Polyposis. J Allergy Clin Immunol Pract. 2020 May; 8(5):1565-1566. PMID: 32173370.
    Citations:    
  13. Naclerio R, Baroody F, Bachert C, Bleier B, Borish L, Brittain E, Chupp G, Fisher A, Fokkens W, Gevaert P, Kennedy D, Kim J, Laidlaw TM, Lee JJ, Piccirillo JF, Pinto JM, Roland LT, Schleimer RP, Schlosser RJ, Schwaninger JM, Smith TL, Tan BK, Tan M, Toskala E, Wenzel S, Togias A. Clinical Research Needs for the Management of Chronic Rhinosinusitis with Nasal Polyps in the New Era of Biologics: A National Institute of Allergy and Infectious Diseases Workshop. J Allergy Clin Immunol Pract. 2020 May; 8(5):1532-1549.e1. PMID: 32142964.
    Citations:    
  14. Laidlaw TM, Buchheit KM. Biologics in chronic rhinosinusitis with nasal polyposis. Ann Allergy Asthma Immunol. 2020 04; 124(4):326-332. PMID: 31830587.
    Citations:    
  15. Roland LT, Nagy C, Wang H, Moore R, Cahill KN, Laidlaw TM, Wise SK, DelGaudio JM, Kuruvilla M, Levy JM. Treatment practices for aspirin-exacerbated respiratory disease: analysis of a national insurance claims database. Int Forum Allergy Rhinol. 2020 02; 10(2):190-193. PMID: 31693796.
    Citations:    
  16. Bachert C, Han JK, Desrosiers M, Hellings PW, Amin N, Lee SE, Mullol J, Greos LS, Bosso JV, Laidlaw TM, Cervin AU, Maspero JF, Hopkins C, Olze H, Canonica GW, Paggiaro P, Cho SH, Fokkens WJ, Fujieda S, Zhang M, Lu X, Fan C, Draikiwicz S, Kamat SA, Khan A, Pirozzi G, Patel N, Graham NMH, Ruddy M, Staudinger H, Weinreich D, Stahl N, Yancopoulos GD, Mannent LP. Efficacy and safety of dupilumab in patients with severe chronic rhinosinusitis with nasal polyps (LIBERTY NP SINUS-24 and LIBERTY NP SINUS-52): results from two multicentre, randomised, double-blind, placebo-controlled, parallel-group phase 3 trials. Lancet. 2019 11 02; 394(10209):1638-1650. PMID: 31543428.
    Citations:    
  17. Cahill KN, Cui J, Kothari P, Murphy K, Raby BA, Singer J, Israel E, Boyce JA, Laidlaw TM. Unique Effect of Aspirin Therapy on Biomarkers in Aspirin-exacerbated Respiratory Disease. A Prospective Trial. Am J Respir Crit Care Med. 2019 09 15; 200(6):704-711. PMID: 30978291.
    Citations:    
  18. Roland LT, Wang H, Mehta CC, Cahill KN, Laidlaw TM, DelGaudio JM, Wise SK, Levy JM. Longitudinal progression of aspirin-exacerbated respiratory disease: analysis of a national insurance claims database. Int Forum Allergy Rhinol. 2019 12; 9(12):1420-1423. PMID: 31442000.
    Citations:    
  19. Li L, Laidlaw T. Cross-reactivity and tolerability of celecoxib in adult patients with NSAID hypersensitivity. J Allergy Clin Immunol Pract. 2019 Nov - Dec; 7(8):2891-2893.e4. PMID: 31100553.
    Citations:    
  20. Laidlaw TM, Mullol J, Fan C, Zhang D, Amin N, Khan A, Chao J, Mannent LP. Dupilumab improves nasal polyp burden and asthma control in patients with CRSwNP and AERD. J Allergy Clin Immunol Pract. 2019 Sep - Oct; 7(7):2462-2465.e1. PMID: 30954643.
    Citations:    
  21. Huang GX, Palumbo ML, Singer JI, Cahill KN, Laidlaw TM. Sinus surgery improves lower respiratory tract reactivity during aspirin desensitization for AERD. J Allergy Clin Immunol Pract. 2019 May - Jun; 7(5):1647-1649. PMID: 30877073.
    Citations:    
  22. Liu T, Barrett NA, Kanaoka Y, Buchheit K, Laidlaw TM, Garofalo D, Lai J, Katz HR, Feng C, Boyce JA. Cysteinyl leukotriene receptor 2 drives lung immunopathology through a platelet and high mobility box 1-dependent mechanism. Mucosal Immunol. 2019 05; 12(3):679-690. PMID: 30664709.
    Citations:    Fields:    
  23. Laidlaw TM. Clinical updates in aspirin-exacerbated respiratory disease. Allergy Asthma Proc. 2019 Jan 01; 40(1):4-6. PMID: 30582489.
    Citations:    Fields:    
  24. Kiladejo A, Palumbo M, Laidlaw TM. Accidental ingestion of aspirin and nonsteroidal anti-inflammatory drugs is common in patients with aspirin-exacerbated respiratory disease. J Allergy Clin Immunol Pract. 2019 May - Jun; 7(5):1656-1658.e2. PMID: 30481585.
    Citations:    Fields:    
  25. DeGregorio GA, Singer J, Cahill KN, Laidlaw T. A 1-Day, 90-Minute Aspirin Challenge and Desensitization Protocol in Aspirin-Exacerbated Respiratory Disease. J Allergy Clin Immunol Pract. 2019 04; 7(4):1174-1180. PMID: 30391549.
    Citations:    Fields:    
  26. Cahill KN, Murphy K, Singer J, Israel E, Boyce JA, Laidlaw TM. Plasma tryptase elevation during aspirin-induced reactions in aspirin-exacerbated respiratory disease. J Allergy Clin Immunol. 2019 02; 143(2):799-803.e2. PMID: 30339852.
    Citations:    Fields:    
  27. Laidlaw TM, Prussin C, Panettieri RA, Lee S, Ferguson BJ, Adappa ND, Lane AP, Palumbo ML, Sullivan M, Archibald D, Dworetzky SI, Hebrank GT, Bozik ME. Dexpramipexole depletes blood and tissue eosinophils in nasal polyps with no change in polyp size. Laryngoscope. 2019 02; 129(2):E61-E66. PMID: 30284267.
    Citations:    Fields:    
  28. Kowalski ML, Agache I, Bavbek S, Bakirtas A, Blanca M, Bochenek G, Bonini M, Heffler E, Klimek L, Laidlaw TM, Mullol J, Nizankowska-Mogilnicka E, Park HS, Sanak M, Sanchez-Borges M, Sanchez-Garcia S, Scadding G, Taniguchi M, Torres MJ, White AA, Wardzynska A. Diagnosis and management of NSAID-Exacerbated Respiratory Disease (N-ERD)-a EAACI position paper. Allergy. 2019 01; 74(1):28-39. PMID: 30216468.
    Citations:    Fields:    
  29. Eid RC, Palumbo ML, Laidlaw TM, Buchheit KM, Cahill KN. A retrospective analysis of esophageal eosinophilia in patients with aspirin-exacerbated respiratory disease. J Allergy Clin Immunol Pract. 2019 04; 7(4):1338-1340. PMID: 30261317.
    Citations:    Fields:    
  30. Laidlaw TM. Pathogenesis of NSAID-induced reactions in aspirin-exacerbated respiratory disease. World J Otorhinolaryngol Head Neck Surg. 2018 Sep; 4(3):162-168. PMID: 30506046.
    Citations:    
  31. Ordovas-Montanes J, Dwyer DF, Nyquist SK, Buchheit KM, Vukovic M, Deb C, Wadsworth MH, Hughes TK, Kazer SW, Yoshimoto E, Cahill KN, Bhattacharyya N, Katz HR, Berger B, Laidlaw TM, Boyce JA, Barrett NA, Shalek AK. Allergic inflammatory memory in human respiratory epithelial progenitor cells. Nature. 2018 08; 560(7720):649-654. PMID: 30135581.
    Citations:    Fields:    
  32. Laidlaw TM, Cahill KN, Cardet JC, Murphy K, Cui J, Dioneda B, Kothari P, Raby BA, Israel E, Boyce JA. A trial of type 12 purinergic (P2Y12) receptor inhibition with prasugrel identifies a potentially distinct endotype of patients with aspirin-exacerbated respiratory disease. J Allergy Clin Immunol. 2019 01; 143(1):316-324.e7. PMID: 29890239.
    Citations:    Fields:    
  33. Tuttle KL, Buchheit KM, Laidlaw TM, Cahill KN. A retrospective analysis of mepolizumab in subjects with aspirin-exacerbated respiratory disease. J Allergy Clin Immunol Pract. 2018 May - Jun; 6(3):1045-1047. PMID: 29501519.
    Citations: 1     Fields:    
  34. Schneider TR, Johns CB, Palumbo ML, Murphy KC, Cahill KN, Laidlaw TM. Dietary Fatty Acid Modification for the Treatment of Aspirin-Exacerbated Respiratory Disease: A Prospective Pilot Trial. J Allergy Clin Immunol Pract. 2018 May - Jun; 6(3):825-831. PMID: 29133219.
    Citations:    Fields:    
  35. Laidlaw TM. Expanding our research horizons. Am J Rhinol Allergy. 2017 Sep 01; 31(5):281-282. PMID: 28859700.
    Citations:    
  36. Cahill KN, Katz HR, Cui J, Lai J, Kazani S, Crosby-Thompson A, Garofalo D, Castro M, Jarjour N, DiMango E, Erzurum S, Trevor JL, Shenoy K, Chinchilli VM, Wechsler ME, Laidlaw TM, Boyce JA, Israel E. KIT Inhibition by Imatinib in Patients with Severe Refractory Asthma. N Engl J Med. 2017 05 18; 376(20):1911-1920. PMID: 28514613.
    Citations: 8     Fields:    Translation:HumansCells
  37. Laidlaw TM, Cahill KN. Current Knowledge and Management of Hypersensitivity to Aspirin and NSAIDs. J Allergy Clin Immunol Pract. 2017 May - Jun; 5(3):537-545. PMID: 28483309.
    Citations:    Fields:    Translation:HumansAnimalsPHPublic Health
  38. Hagan JB, Laidlaw TM, Divekar R, O'Brien EK, Kita H, Volcheck GW, Hagan CR, Lal D, Teaford HG, Erwin PJ, Zhang N, Rank MA. Urinary Leukotriene E4 to Determine Aspirin Intolerance in Asthma: A Systematic Review and Meta-Analysis. J Allergy Clin Immunol Pract. 2017 Jul - Aug; 5(4):990-997.e1. PMID: 28202405.
    Citations: 1     Fields:    Translation:Humans
  39. Cahill KN, Laidlaw TM. Pathogenesis of Aspirin-Induced Reactions in Aspirin-Exacerbated Respiratory Disease. Immunol Allergy Clin North Am. 2016 11; 36(4):681-691. PMID: 27712763.
    Citations: 1     Fields:    Translation:Humans
  40. Cahill KN, Johns CB, Cui J, Wickner P, Bates DW, Laidlaw TM, Beeler PE. Automated identification of an aspirin-exacerbated respiratory disease cohort. J Allergy Clin Immunol. 2017 Mar; 139(3):819-825.e6. PMID: 27567328.
    Citations: 2     Fields:    Translation:Humans
  41. Shah NH, Schneider TR, DeFaria Yeh D, Cahill KN, Laidlaw TM. Eosinophilia-Associated Coronary Artery Vasospasm in Patients with Aspirin-Exacerbated Respiratory Disease. J Allergy Clin Immunol Pract. 2016 Nov - Dec; 4(6):1215-1219. PMID: 27396680.
    Citations:    Fields:    Translation:Humans
  42. Tuttle KL, Schneider TR, Henrickson SE, Morris D, Abonia JP, Spergel JM, Laidlaw TM. Aspirin-exacerbated respiratory disease: not always "adult-onset". J Allergy Clin Immunol Pract. 2016 Jul-Aug; 4(4):756-8. PMID: 27393784.
    Citations: 1     Fields:    Translation:Humans
  43. Buchheit KM, Laidlaw TM. Update on the Management of Aspirin-Exacerbated Respiratory Disease. Allergy Asthma Immunol Res. 2016 Jul; 8(4):298-304. PMID: 27126722.
    Citations: 5     
  44. Yamaguchi M, Zacharia J, Laidlaw TM, Balestrieri B. PLA2G5 regulates transglutaminase activity of human IL-4-activated M2 macrophages through PGE2 generation. J Leukoc Biol. 2016 07; 100(1):131-41. PMID: 26936936.
    Citations: 4     Fields:    Translation:HumansCells
  45. Sloane D, Govindarajulu U, Harrow-Mortelliti J, Barry W, Hsu FI, Hong D, Laidlaw T, Palis R, Legere H, Bunyavanich S, Breslow R, Wesemann D, Barrett N, Brennan P, Chong HJ, Liu A, Fernandez J, Fanning L, Kyin T, Cahill K, Bankova L, Lynch A, Berlin S, Campos S, Fuchs C, Mayer R, Matulonis U, Castells M. Safety, Costs, and Efficacy of Rapid Drug Desensitizations to Chemotherapy and Monoclonal Antibodies. J Allergy Clin Immunol Pract. 2016 May-Jun; 4(3):497-504. PMID: 26895621.
    Citations: 5     Fields:    Translation:Humans
  46. Laidlaw TM, Boyce JA. Aspirin-Exacerbated Respiratory Disease--New Prime Suspects. N Engl J Med. 2016 Feb 04; 374(5):484-8. PMID: 26840139.
    Citations: 15     Fields:    Translation:Humans
  47. Cahill KN, Raby BA, Zhou X, Guo F, Thibault D, Baccarelli A, Byun HM, Bhattacharyya N, Steinke JW, Boyce JA, Laidlaw TM. Impaired E Prostanoid2 Expression and Resistance to Prostaglandin E2 in Nasal Polyp Fibroblasts from Subjects with Aspirin-Exacerbated Respiratory Disease. Am J Respir Cell Mol Biol. 2016 Jan; 54(1):34-40. PMID: 26051534.
    Citations: 9     Fields:    Translation:HumansCells
  48. Buchheit KM, Cahill KN, Katz HR, Murphy KC, Feng C, Lee-Sarwar K, Lai J, Bhattacharyya N, Israel E, Boyce JA, Laidlaw TM. Thymic stromal lymphopoietin controls prostaglandin D2 generation in patients with aspirin-exacerbated respiratory disease. J Allergy Clin Immunol. 2016 05; 137(5):1566-1576.e5. PMID: 26691435.
    Citations: 15     Fields:    Translation:HumansCells
  49. Liu T, Kanaoka Y, Barrett NA, Feng C, Garofalo D, Lai J, Buchheit K, Bhattacharya N, Laidlaw TM, Katz HR, Boyce JA. Aspirin-Exacerbated Respiratory Disease Involves a Cysteinyl Leukotriene-Driven IL-33-Mediated Mast Cell Activation Pathway. J Immunol. 2015 Oct 15; 195(8):3537-45. PMID: 26342029.
    Citations: 14     Fields:    Translation:HumansAnimalsCellsCTClinical Trials
  50. Laidlaw TM. How Patient Experiences Should Change Our Approach to Treating Patients with Aspirin-Exacerbated Respiratory Disease. J Allergy Clin Immunol Pract. 2015 Sep-Oct; 3(5):719-20. PMID: 26362552.
    Citations: 1     Fields:    Translation:Humans
  51. Laidlaw TM, Boyce JA. Platelets in patients with aspirin-exacerbated respiratory disease. J Allergy Clin Immunol. 2015 Jun; 135(6):1407-14; quiz 1415. PMID: 26051947.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  52. Liu T, Garofalo D, Feng C, Lai J, Katz H, Laidlaw TM, Boyce JA. Platelet-driven leukotriene C4-mediated airway inflammation in mice is aspirin-sensitive and depends on T prostanoid receptors. J Immunol. 2015 Jun 01; 194(11):5061-8. PMID: 25904552.
    Citations: 2     Fields:    Translation:AnimalsCells
  53. Lee-Sarwar K, Johns C, Laidlaw TM, Cahill KN. Tolerance of daily low-dose aspirin does not preclude aspirin-exacerbated respiratory disease. J Allergy Clin Immunol Pract. 2015 May-Jun; 3(3):449-51. PMID: 25634222.
    Citations: 4     Fields:    Translation:Humans
  54. Cahill KN, Laidlaw TM. Aspirin exacerbated respiratory disease: the search for a biomarker. Ann Allergy Asthma Immunol. 2014 Nov; 113(5):500-1. PMID: 25442693.
    Citations: 4     Fields:    Translation:Humans
  55. Cahill KN, Bensko JC, Boyce JA, Laidlaw TM. Prostaglandin D2: a dominant mediator of aspirin-exacerbated respiratory disease. J Allergy Clin Immunol. 2015 Jan; 135(1):245-52. PMID: 25218285.
    Citations: 27     Fields:    Translation:HumansCells
  56. Johns CB, Laidlaw TM. Elevated total serum IgE in nonatopic patients with aspirin-exacerbated respiratory disease. Am J Rhinol Allergy. 2014 Jul-Aug; 28(4):287-9. PMID: 25197914.
    Citations: 7     Fields:    Translation:Humans
  57. Cardet JC, White AA, Barrett NA, Feldweg AM, Wickner PG, Savage J, Bhattacharyya N, Laidlaw TM. Alcohol-induced respiratory symptoms are common in patients with aspirin exacerbated respiratory disease. J Allergy Clin Immunol Pract. 2014 Mar-Apr; 2(2):208-13.. PMID: 24607050.
    Citations: 7     Fields:    Translation:Humans
  58. Laidlaw TM, Cutler AJ, Kidder MS, Liu T, Cardet JC, Chhay H, Feng C, Boyce JA. Prostaglandin E2 resistance in granulocytes from patients with aspirin-exacerbated respiratory disease. J Allergy Clin Immunol. 2014 Jun; 133(6):1692-701.e3. PMID: 24486071.
    Citations: 10     Fields:    Translation:HumansCells
  59. Cummings HE, Liu T, Feng C, Laidlaw TM, Conley PB, Kanaoka Y, Boyce JA. Cutting edge: Leukotriene C4 activates mouse platelets in plasma exclusively through the type 2 cysteinyl leukotriene receptor. J Immunol. 2013 Dec 15; 191(12):5807-10. PMID: 24244016.
    Citations: 9     Fields:    Translation:AnimalsCells
  60. Liu T, Laidlaw TM, Katz HR, Boyce JA. Prostaglandin E2 deficiency causes a phenotype of aspirin sensitivity that depends on platelets and cysteinyl leukotrienes. Proc Natl Acad Sci U S A. 2013 Oct 15; 110(42):16987-92. PMID: 24085850.
    Citations: 30     Fields:    Translation:HumansAnimalsCells
  61. Laidlaw TM, Boyce JA. Pathogenesis of aspirin-exacerbated respiratory disease and reactions. Immunol Allergy Clin North Am. 2013 May; 33(2):195-210. PMID: 23639708.
    Citations: 18     Fields:    Translation:HumansAnimalsCells
  62. Laidlaw TM, Boyce JA. Cysteinyl leukotriene receptors, old and new; implications for asthma. Clin Exp Allergy. 2012 Sep; 42(9):1313-20. PMID: 22925317.
    Citations: 20     Fields:    Translation:HumansAnimalsCells
  63. Liu T, Laidlaw TM, Feng C, Xing W, Shen S, Milne GL, Boyce JA. Prostaglandin E2 deficiency uncovers a dominant role for thromboxane A2 in house dust mite-induced allergic pulmonary inflammation. Proc Natl Acad Sci U S A. 2012 Jul 31; 109(31):12692-7. PMID: 22802632.
    Citations: 21     Fields:    Translation:AnimalsCells
  64. Laidlaw TM, Kidder MS, Bhattacharyya N, Xing W, Shen S, Milne GL, Castells MC, Chhay H, Boyce JA. Cysteinyl leukotriene overproduction in aspirin-exacerbated respiratory disease is driven by platelet-adherent leukocytes. Blood. 2012 Apr 19; 119(16):3790-8. PMID: 22262771.
    Citations: 48     Fields:    Translation:HumansCells
  65. Laidlaw TM, Steinke JW, Tiñana AM, Feng C, Xing W, Lam BK, Paruchuri S, Boyce JA, Borish L. Characterization of a novel human mast cell line that responds to stem cell factor and expresses functional FceRI. J Allergy Clin Immunol. 2011 Mar; 127(3):815-22.e1-5. PMID: 21281958.
    Citations: 13     Fields:    Translation:HumansCells
  66. He P, Laidlaw T, Maekawa A, Kanaoka Y, Xu K, Lam BK. Oxidative stress suppresses cysteinyl leukotriene generation by mouse bone marrow-derived mast cells. J Biol Chem. 2011 Mar 11; 286(10):8277-86. PMID: 21233206.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  67. Andrew A. White, Tanya M. Laidlaw, Katherine Woessner. Anaphylaxis and Hypersensitivity Reactions; M.C. Castells (Ed.). Aspirin and NSAID Reactions: Diagnosis, Pathophysiology, and Management. 2011; 107-126.
  68. Lundequist A, Nallamshetty SN, Xing W, Feng C, Laidlaw TM, Uematsu S, Akira S, Boyce JA. Prostaglandin E(2) exerts homeostatic regulation of pulmonary vascular remodeling in allergic airway inflammation. J Immunol. 2010 Jan 01; 184(1):433-41. PMID: 20028661.
    Citations: 24     Fields:    Translation:Animals
  69. TM Laidlaw, BA Markens, L Borish, JA Boyce. American Academy of Allergy, Asthma & Immunology national meeting, 2009. Peripheral Blood Cyclooxygenase (COX) Deficiency in Aspirin Exacerbated Respiratory Disease (AERD) and Regulation of Eicosanoid Enzymes by Aspirin Desensitization. 2009.
  70. Castells MC, Tennant NM, Sloane DE, Hsu FI, Barrett NA, Hong DI, Laidlaw TM, Legere HJ, Nallamshetty SN, Palis RI, Rao JJ, Berlin ST, Campos SM, Matulonis UA. Hypersensitivity reactions to chemotherapy: outcomes and safety of rapid desensitization in 413 cases. J Allergy Clin Immunol. 2008 Sep; 122(3):574-80. PMID: 18502492.
    Citations: 43     Fields:    Translation:Humans
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.