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Mark Emile Pepin, M.D., Ph.D.

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Brigham and Women's Hospital, Harvard Medical School, Boston, MAInternal Medicine
University of Alabama at Birmingham, Birmingham, ALMD2020Medicine
University of Alabama at Birmingham, Birmingham, ALPhD2019Biomedical Engineering
University of California, Davis, Davis, CAMS2013Biomedical Engineering
Clemson University, Clemson, SCBS2011Chemical Engineering
"Tinsley R. Harrison" Award for Excellence in Internal Medicine
Article Impact Award
Featured Graduate Researcher
Humboldt International Research Fellowship
UASOM Student Lifetime Achievement Award
“William C. Stanley” Early Investigator Award
“Samuel B. Barker” Award for Scientific Excellence
Graduate Trainee Speaker Award
2nd Place Poster Award
1st Place Poster Award
1st Place Poster Award
NIH/NHLBI Ruth L. Kirschstein National Research Service Award (F30)
Travel Award
1st Place Oral Presentation
1st Place Poster Award
Dean’s Research Award
HAAG Fellowship
All-ACC Student-Athlete Award
Cryovac Endowed Engineer Award
"Donald F. Othmer" Academic Excellence Award
Palmetto Fellowship

The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. (Mark E. Pepin) Dec 1, 2021 - Aug 1, 2023
    Intuitive and Standardized Bulk RNA-Sequencing Analysis Platform for the Coding-Naïve Basic Scientist
    Role: Principal Investigator
  2. (Mark E. Pepin) Sep 30, 2021 - Sep 30, 2022
    Deutsche Gesellschaft für Kardiologie
    CaMKIId and EZH2 as epigenetic determinants of heart failure-induced renal cancer susceptibility
    Role: Principal Investigator
  3. (Mark E. Pepin) Dec 1, 2020 - May 31, 2022
    Alexander von Humboldt Stiftung
    The role of CaMKII-dependent histone modification in heart failure-induced carcinogenesis
    Role: Principal Investigator
  4. (Mark E. Pepin) Sep 30, 2018 - May 13, 2020
    University of Alabama at Birmingham
    Developing an Integrated Media Production Studio for Medical Education
    Role: Principal Investigator
  5. F30HL137240 (PEPIN, MARK EMILE) Apr 1, 2018 - Mar 31, 2020
    GADD45B and Metabolic Memory in Diabetic Heart Failure
    Role: Principal Investigator

Featured Content

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Lennermann DC, Pepin ME, Grosch M, Konrad L, Kemmling E, Hartmann J, Nolte JL, Clauder-Münster S, Kayvanpour E, Sedaghat-Hamedani F, Haas J, Meder B, van den Boogaard M, Amin AS, Dewenter M, Krüger M, Steinmetz LM, Backs J, van den Hoogenhof MMG. Deep phenotyping of two preclinical mouse models and a cohort of RBM20 mutation carriers reveals no sex-dependent disease severity in RBM20 cardiomyopathy. Am J Physiol Heart Circ Physiol. 2022 12 01; 323(6):H1296-H1310. PMID: 36367695.
    Citations:    Fields:    
  2. Souder JP, Pepin ME, Seay RL, Lorenz RG, Geisler WM, Yacoubian T. A novel curricular framework to develop grant writing skills among MD-PhD students. J Clin Transl Sci. 2022; 6(1):e54. PMID: 35656336; PMCID: PMC9120620.
  3. Pepin ME, Souder JP, Weaver AN, Lorenz RG, Yacoubian T, Seay RL. Fostering a diverse regional community of physician-scientist trainees. J Natl Med Assoc. 2022 Jun; 114(3):251-257. PMID: 35232610; PMCID: PMC9189008.
    Citations:    Fields:    Translation:Humans
  4. Pepin ME, Saca E, Kwon SY, May J. A case of "smoldering" immune-mediated thrombotic thrombocytopenic purpura manifesting as recurrent cardioembolic stroke. Clin Case Rep. 2021 Oct; 9(10):e04850. PMID: 34667601; PMCID: PMC8507438.
  5. Quiles JM, Pepin ME, Sunny S, Shelar SB, Challa AK, Dalley B, Hoidal JR, Pogwizd SM, Wende AR, Rajasekaran NS. Identification of Nrf2-responsive microRNA networks as putative mediators of myocardial reductive stress. Sci Rep. 2021 06 07; 11(1):11977. PMID: 34099738; PMCID: PMC8184797.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  6. Pepin ME, Ha CM, Potter LA, Bakshi S, Barchue JP, Haj Asaad A, Pogwizd SM, Pamboukian SV, Hidalgo BA, Vickers SM, Wende AR. Racial and socioeconomic disparity associates with differences in cardiac DNA methylation among men with end-stage heart failure. Am J Physiol Heart Circ Physiol. 2021 05 01; 320(5):H2066-H2079. PMID: 33769919; PMCID: PMC8163657.
    Citations: 4     Fields:    Translation:HumansCells
  7. Pepin ME, Schiano C, Miceli M, Benincasa G, Mansueto G, Grimaldi V, Soricelli A, Wende AR, Napoli C. The human aortic endothelium undergoes dose-dependent DNA methylation in response to transient hyperglycemia. Exp Cell Res. 2021 03 15; 400(2):112485. PMID: 33515594; PMCID: PMC8038422.
    Citations: 10     Fields:    Translation:HumansCells
  8. Brahma MK, Ha CM, Pepin ME, Mia S, Sun Z, Chatham JC, Habegger KM, Abel ED, Paterson AJ, Young ME, Wende AR. Increased Glucose Availability Attenuates Myocardial Ketone Body Utilization. J Am Heart Assoc. 2020 08 04; 9(15):e013039. PMID: 32750298; PMCID: PMC7792234.
    Citations: 21     Fields:    Translation:AnimalsCells
  9. Wende AR, Schell JC, Ha CM, Pepin ME, Khalimonchuk O, Schwertz H, Pereira RO, Brahma MK, Tuinei J, Contreras-Ferrat A, Wang L, Andrizzi CA, Olsen CD, Bradley WE, Dell'Italia LJ, Dillmann WH, Litwin SE, Abel ED. Maintaining Myocardial Glucose Utilization in Diabetic Cardiomyopathy Accelerates Mitochondrial Dysfunction. Diabetes. 2020 10; 69(10):2094-2111. PMID: 32366681; PMCID: PMC7506832.
    Citations: 22     Fields:    Translation:AnimalsCells
  10. Pepin ME, Infante T, Benincasa G, Schiano C, Miceli M, Ceccarelli S, Megiorni F, Anastasiadou E, Della Valle G, Fatone G, Faenza M, Docimo L, Nicoletti GF, Marchese C, Wende AR, Napoli C. Differential DNA Methylation Encodes Proliferation and Senescence Programs in Human Adipose-Derived Mesenchymal Stem Cells. Front Genet. 2020; 11:346. PMID: 32351540; PMCID: PMC7174643.
    Citations: 7     
  11. Pepin ME, Koentges C, Pfeil K, Gollmer J, Kersting S, Wiese S, Hoffmann MM, Odening KE, von Zur Mühlen C, Diehl P, Stachon P, Wolf D, Wende AR, Bode C, Zirlik A, Bugger H. Dysregulation of the Mitochondrial Proteome Occurs in Mice Lacking Adiponectin Receptor 1. Front Endocrinol (Lausanne). 2019; 10:872. PMID: 31920982; PMCID: PMC6923683.
    Citations: 3     Fields:    
  12. Pepin ME, Drakos S, Ha CM, Tristani-Firouzi M, Selzman CH, Fang JC, Wende AR, Wever-Pinzon O. DNA methylation reprograms cardiac metabolic gene expression in end-stage human heart failure. Am J Physiol Heart Circ Physiol. 2019 10 01; 317(4):H674-H684. PMID: 31298559; PMCID: PMC6843013.
    Citations: 21     Fields:    Translation:HumansAnimalsCells
  13. Webb WM, Irwin AB, Pepin ME, Henderson BW, Huang V, Butler AA, Herskowitz JH, Wende AR, Cash AE, Lubin FD. The SETD6 Methyltransferase Plays an Essential Role in Hippocampus-Dependent Memory Formation. Biol Psychiatry. 2020 03 15; 87(6):577-587. PMID: 31378303; PMCID: PMC6906268.
    Citations: 1     Fields:    Translation:AnimalsCells
  14. Pepin ME, Bickerton HH, Bethea M, Hunter CS, Wende AR, Banerjee RR. Prolactin Receptor Signaling Regulates a Pregnancy-Specific Transcriptional Program in Mouse Islets. Endocrinology. 2019 05 01; 160(5):1150-1163. PMID: 31004482; PMCID: PMC6475113.
    Citations: 8     Fields:    Translation:AnimalsCells
  15. Pepin ME, Webb WM, Boppana S, Weaver AN, Seay RL, Dempsey DM, Willig JH, Geisler WM, Lorenz RG. Gamification: An Innovative Approach to Reinforce Clinical Knowledge for MD-PhD Students During Their PhD Research Years. Med Sci Educ. 2019 Sep 15; 29(3):739-747. PMID: 32071793; PMCID: PMC7028303.
    Citations: 2     
  16. Pepin ME, Wende AR. Epigenetics in the development of diabetic cardiomyopathy. Epigenomics. 2019 04; 11(5):469-472. PMID: 30895816.
    Citations: 3     Fields:    Translation:HumansCells
  17. Lever JM, Hull TD, Boddu R, Pepin ME, Black LM, Adedoyin OO, Yang Z, Traylor AM, Jiang Y, Li Z, Peabody JE, Eckenrode HE, Crossman DK, Crowley MR, Bolisetty S, Zimmerman KA, Wende AR, Mrug M, Yoder BK, Agarwal A, George JF. Resident macrophages reprogram toward a developmental state after acute kidney injury. JCI Insight. 2019 Jan 24; 4(2). PMID: 30674729; PMCID: PMC6413788.
    Citations: 35     Fields:    
  18. Pepin ME, Ha CM, Crossman DK, Litovsky SH, Varambally S, Barchue JP, Pamboukian SV, Diakos NA, Drakos SG, Pogwizd SM, Wende AR. Genome-wide DNA methylation encodes cardiac transcriptional reprogramming in human ischemic heart failure. Lab Invest. 2019 03; 99(3):371-386. PMID: 30089854; PMCID: PMC6515060.
    Citations: 30     Fields:    Translation:HumansAnimalsCells
  19. Kim T, Nason S, Holleman C, Pepin M, Wilson L, Berryhill TF, Wende AR, Steele C, Young ME, Barnes S, Drucker DJ, Finan B, DiMarchi R, Perez-Tilve D, Tschöp M, Habegger KM. Glucagon Receptor Signaling Regulates Energy Metabolism via Hepatic Farnesoid X Receptor and Fibroblast Growth Factor 21. Diabetes. 2018 09; 67(9):1773-1782. PMID: 29925501; PMCID: PMC6110317.
    Citations: 26     Fields:    Translation:AnimalsCells
  20. Pepin ME, Padgett LE, McDowell RE, Burg AR, Brahma MK, Holleman C, Kim T, Crossman D, Kutsch O, Tse HM, Wende AR, Habegger KM. Antiretroviral therapy potentiates high-fat diet induced obesity and glucose intolerance. Mol Metab. 2018 06; 12:48-61. PMID: 29731256; PMCID: PMC6001921.
    Citations: 8     Fields:    Translation:AnimalsCells
  21. Baños JH, Pepin ME, Van Wagoner N. Class-Wide Access to a Commercial Step 1 Question Bank During Preclinical Organ-Based Modules: A Pilot Project. Acad Med. 2018 03; 93(3):486-490. PMID: 28817433; PMCID: PMC6706270.
    Citations: 10     Fields:    Translation:Humans
  22. Koentges C, Pepin ME, Müsse C, Pfeil K, Alvarez SVV, Hoppe N, Hoffmann MM, Odening KE, Sossalla S, Zirlik A, Hein L, Bode C, Wende AR, Bugger H. Gene expression analysis to identify mechanisms underlying heart failure susceptibility in mice and humans. Basic Res Cardiol. 2018 01 08; 113(1):8. PMID: 29288409; PMCID: PMC5764079.
    Citations: 18     Fields:    Translation:AnimalsCells
  23. Wende AR, Kim J, Holland WL, Wayment BE, O'Neill BT, Tuinei J, Brahma MK, Pepin ME, McCrory MA, Luptak I, Halade GV, Litwin SE, Abel ED. Glucose transporter 4-deficient hearts develop maladaptive hypertrophy in response to physiological or pathological stresses. Am J Physiol Heart Circ Physiol. 2017 Dec 01; 313(6):H1098-H1108. PMID: 28822962; PMCID: PMC5814656.
    Citations: 22     Fields:    Translation:Animals
  24. Brahma MK, Pepin ME, Wende AR. My Sweetheart Is Broken: Role of Glucose in Diabetic Cardiomyopathy. Diabetes Metab J. 2017 Feb; 41(1):1-9. PMID: 28236380; PMCID: PMC5328690.
    Citations: 22     
  25. MacKenzie MG, Hamilton DL, Pepin M, Patton A, Baar K. Inhibition of myostatin signaling through Notch activation following acute resistance exercise. PLoS One. 2013; 8(7):e68743. PMID: 23844238; PMCID: PMC3699505.
    Citations: 27     Fields:    Translation:HumansAnimalsCells
  26. Kelly JC, Pepin M, Huber DL, Bunker BC, Roberts ME. Reversible control of electrochemical properties using thermally-responsive polymer electrolytes. Adv Mater. 2012 Feb 14; 24(7):886-9. PMID: 22253076.
    Citations: 1     Fields:    Translation:Cells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.