Contact, publication, and social network information about Harvard faculty and fellows. Harvard Catalyst Profiles
Last Name

profileJustin P Annes, Ph.D., M.D.

TitlePost Doc, Visiting (Stip) (EXT)
InstitutionFaculty of Arts & Sciences
DepartmentStem Cell and Regenerative Biology
AddressHarvard, Stem Cell and Regenerative Biology
Sherman Fairchild Biochemistry Bldg
7 Divinity Ave
Cambridge MA 02138
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Collapse Research 
Collapse research activities and funding
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
R01DK101530     (ANNES, JUSTIN PIERCE)Sep 1, 2015 - Jul 31, 2020
The Role of Adenosine Kinase in Controlling Beta-Cell Regeneration
Role: Principal Investigator

R03DK098143     (ANNES, JUSTIN PIERCE)Apr 1, 2013 - Mar 31, 2015
Interrogating the Role of Adenosine Kinase in Islet Beta-Cells
Role: Principal Investigator

K08DK084206     (ANNES, JUSTIN PIERCE)Jul 16, 2009 - Jun 30, 2014
Pancreatic Beta-Cell Regeneration: Expanding the functional Mass
Role: Principal Investigator

Collapse Bibliographic 
Collapse selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Nagy N, de la Zerda A, Kaber G, Johnson PY, Hu KH, Kratochvil MJ, Yadava K, Zhao W, Cui Y, Navarro G, Annes JP, Wight TN, Heilshorn SC, Bollyky PL, Butte MJ. Hyaluronan content governs tissue stiffness in pancreatic islet inflammation. J Biol Chem. 2017 Nov 28. PMID: 29183997.
    View in: PubMed
  2. Navarro G, Abdolazami Y, Zhao Z, Xu H, Lee S, Armstrong NA, Annes JP. Erratum. Genetic Disruption of Adenosine Kinase in Mouse Pancreatic ß-Cells Protects Against High-Fat Diet-Induced Glucose Intolerance. Diabetes 2017;66:1928-1938. Diabetes. 2017 Dec; 66(12):3145. PMID: 29017999.
    View in: PubMed
  3. Navarro G, Abdolazami Y, Zhao Z, Xu H, Lee S, Armstrong NA, Annes JP. Genetic Disruption of Adenosine Kinase in Mouse Pancreatic ß-Cells Protects Against High-Fat Diet-Induced Glucose Intolerance. Diabetes. 2017 Jul; 66(7):1928-1938. PMID: 28468960.
    View in: PubMed
  4. Hosseini-Nassab N, Samanta D, Abdolazimi Y, Annes JP, Zare RN. Electrically controlled release of insulin using polypyrrole nanoparticles. Nanoscale. 2017 Jan 07; 9(1):143-149. PMID: 27929180.
    View in: PubMed
  5. Zhao Z, Abdolazimi Y, Armstrong NA, Annes JP. A High-content In Vitro Pancreatic Islet ß-cell Replication Discovery Platform. J Vis Exp. 2016 Jul 16; (113). PMID: 27500720.
    View in: PubMed
  6. Zhao Z, Low YS, Armstrong NA, Ryu JH, Sun SA, Arvanites AC, Hollister-Lock J, Shah NH, Weir GC, Annes JP. Repurposing cAMP-modulating medications to promote ß-cell replication. Mol Endocrinol. 2014 Oct; 28(10):1682-97. PMID: 25083741; PMCID: PMC4179632.
  7. Nichols RJ, New C, Annes JP. Adult tissue sources for new ß cells. Transl Res. 2014 Apr; 163(4):418-31. PMID: 24345765; PMCID: PMC3976738.
  8. Wei K, Piecewicz SM, McGinnis LM, Taniguchi CM, Wiegand SJ, Anderson K, Chan CW, Mulligan KX, Kuo D, Yuan J, Vallon M, Morton L, Lefai E, Simon MC, Maher JJ, Mithieux G, Rajas F, Annes J, McGuinness OP, Thurston G, Giaccia AJ, Kuo CJ. A liver Hif-2a-Irs2 pathway sensitizes hepatic insulin signaling and is modulated by Vegf inhibition. Nat Med. 2013 Oct; 19(10):1331-1337. PMID: 24037094; PMCID: PMC3795838.
  9. Vaidya A, Underwood PC, Annes JP, Sun B, Williams GH, Forman JP, Williams JS. The influence of sodium- and calcium-regulatory hormone interventions on adipocytokines in obesity and diabetes. Metabolism. 2013 Apr; 62(4):539-47. PMID: 23142162; PMCID: PMC3572332.
  10. Chen CA, Carolan PJ, Carolan PC, Annes JP. In vivo screening for secreted proteins that modulate glucose handling identifies interleukin-6 family members as potent hypoglycemic agents. PLoS One. 2012; 7(9):e44600. PMID: 22962620; PMCID: PMC3433445.
  11. Bar-Lev A, Annes JP. Genetics of adrenocortical disease: an update. Curr Opin Endocrinol Diabetes Obes. 2012 Jun; 19(3):159-67. PMID: 22476103.
    View in: PubMed
  12. Annes JP, Ryu JH, Lam K, Carolan PJ, Utz K, Hollister-Lock J, Arvanites AC, Rubin LL, Weir G, Melton DA. Adenosine kinase inhibition selectively promotes rodent and porcine islet ß-cell replication. Proc Natl Acad Sci U S A. 2012 Mar 06; 109(10):3915-20. PMID: 22345561; PMCID: PMC3309788.
  13. Volpicelli ER, Doyle L, Annes JP, Murray MF, Jacobsen E, Murphy GF, Saavedra AP. Erdheim-Chester disease presenting with cutaneous involvement: a case report and literature review. J Cutan Pathol. 2011 Mar; 38(3):280-5. PMID: 21143617; PMCID: PMC3619727.
  14. Annes JP, Giovanni MA, Murray MF. Risks of presymptomatic direct-to-consumer genetic testing. N Engl J Med. 2010 Sep 16; 363(12):1100-1. PMID: 20843242.
    View in: PubMed
  15. Annes JP, Chen Y, Munger JS, Rifkin DB. Integrin alphaVbeta6-mediated activation of latent TGF-beta requires the latent TGF-beta binding protein-1. J Cell Biol. 2004 Jun 07; 165(5):723-34. PMID: 15184403; PMCID: PMC2172370.
  16. Annes J, Vassallo M, Munger JS, Rifkin DB. A genetic screen to identify latent transforming growth factor beta activators. Anal Biochem. 2004 Apr 01; 327(1):45-54. PMID: 15033509.
    View in: PubMed
  17. Krishnan S, Deora AB, Annes JP, Osoria J, Rifkin DB, Hajjar KA. Annexin II-mediated plasmin generation activates TGF-beta3 during epithelial-mesenchymal transformation in the developing avian heart. Dev Biol. 2004 Jan 01; 265(1):140-54. PMID: 14697359.
    View in: PubMed
  18. Annes JP, Munger JS, Rifkin DB. Making sense of latent TGFbeta activation. J Cell Sci. 2003 Jan 15; 116(Pt 2):217-24. PMID: 12482908.
    View in: PubMed
  19. Chen Y, Dabovic B, Annes JP, Rifkin DB. Latent TGF-beta binding protein-3 (LTBP-3) requires binding to TGF-beta for secretion. FEBS Lett. 2002 Apr 24; 517(1-3):277-80. PMID: 12062452.
    View in: PubMed
  20. Annes JP, Rifkin DB, Munger JS. The integrin alphaVbeta6 binds and activates latent TGFbeta3. FEBS Lett. 2002 Jan 30; 511(1-3):65-8. PMID: 11821050.
    View in: PubMed
  21. Gualandris A, Annes JP, Arese M, Noguera I, Jurukovski V, Rifkin DB. The latent transforming growth factor-beta-binding protein-1 promotes in vitro differentiation of embryonic stem cells into endothelium. Mol Biol Cell. 2000 Dec; 11(12):4295-308. PMID: 11102524; PMCID: PMC15073.
  22. Sun Z, Arendt CW, Ellmeier W, Schaeffer EM, Sunshine MJ, Gandhi L, Annes J, Petrzilka D, Kupfer A, Schwartzberg PL, Littman DR. PKC-theta is required for TCR-induced NF-kappaB activation in mature but not immature T lymphocytes. Nature. 2000 Mar 23; 404(6776):402-7. PMID: 10746729.
    View in: PubMed
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