Harvard Catalyst Profiles

Contact, publication, and social network information about Harvard faculty and fellows.

Justin P Annes, Ph.D., M.D.


The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01DK119955 (ANNES, JUSTIN PIERCE) Aug 1, 2019 - Jul 31, 2024
    Development of Beta-Cell-Targeted Regenerative Therapeutics Using A Novel Prodrug Strategy
    Role: Principal Investigator
  2. R01DK101530 (ANNES, JUSTIN PIERCE) Sep 1, 2015 - Jul 31, 2020
    The Role of Adenosine Kinase in Controlling Beta-Cell Regeneration
    Role: Principal Investigator
  3. R03DK098143 (ANNES, JUSTIN PIERCE) Apr 1, 2013 - Mar 31, 2015
    Interrogating the Role of Adenosine Kinase in Islet Beta-Cells
    Role: Principal Investigator
  4. K08DK084206 (ANNES, JUSTIN PIERCE) Jul 16, 2009 - Jun 30, 2014
    Pancreatic Beta-Cell Regeneration: Expanding the functional Mass
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Alobuia W, Annes J, Kebebew E. Genetic testing in endocrine surgery: Opportunities for precision surgery. Surgery. 2020 May 03. PMID: 32376047.
  2. Allegretti PA, Horton TM, Abdolazimi Y, Moeller HP, Yeh B, Caffet M, Michel G, Smith M, Annes JP. Generation of highly potent DYRK1A-dependent inducers of human ß-Cell replication via Multi-Dimensional compound optimization. Bioorg Med Chem. 2020 Jan 01; 28(1):115193. PMID: 31757680.
  3. Horton TM, Allegretti PA, Lee S, Moeller HP, Smith M, Annes JP. Zinc-Chelating Small Molecules Preferentially Accumulate and Function within Pancreatic ß Cells. Cell Chem Biol. 2019 02 21; 26(2):213-222.e6. PMID: 30527998.
    Citations:    Fields:    
  4. Abdolazimi Y, Zhao Z, Lee S, Xu H, Allegretti P, Horton TM, Yeh B, Moeller HP, Nichols RJ, McCutcheon D, Shalizi A, Smith M, Armstrong NA, Annes JP. CC-401 Promotes ß-Cell Replication via Pleiotropic Consequences of DYRK1A/B Inhibition. Endocrinology. 2018 09 01; 159(9):3143-3157. PMID: 29514186.
  5. Nagy N, de la Zerda A, Kaber G, Johnson PY, Hu KH, Kratochvil MJ, Yadava K, Zhao W, Cui Y, Navarro G, Annes JP, Wight TN, Heilshorn SC, Bollyky PL, Butte MJ. Hyaluronan content governs tissue stiffness in pancreatic islet inflammation. J Biol Chem. 2018 01 12; 293(2):567-578. PMID: 29183997.
    Citations:    Fields:    Translation:HumansAnimalsCells
  6. Navarro G, Abdolazami Y, Zhao Z, Xu H, Lee S, Armstrong NA, Annes JP. Erratum. Genetic Disruption of Adenosine Kinase in Mouse Pancreatic ß-Cells Protects Against High-Fat Diet-Induced Glucose Intolerance. Diabetes 2017;66:1928-1938. Diabetes. 2017 12; 66(12):3145. PMID: 29017999.
    Citations:    Fields:    
  7. Navarro G, Abdolazimi Y, Zhao Z, Xu H, Lee S, Armstrong NA, Annes JP. Genetic Disruption of Adenosine Kinase in Mouse Pancreatic ß-Cells Protects Against High-Fat Diet-Induced Glucose Intolerance. Diabetes. 2017 07; 66(7):1928-1938. PMID: 28468960.
    Citations:    Fields:    Translation:AnimalsCells
  8. Hosseini-Nassab N, Samanta D, Abdolazimi Y, Annes JP, Zare RN. Electrically controlled release of insulin using polypyrrole nanoparticles. Nanoscale. 2017 Jan 07; 9(1):143-149. PMID: 27929180.
    Citations:    Fields:    
  9. Zhao Z, Abdolazimi Y, Armstrong NA, Annes JP. A High-content In Vitro Pancreatic Islet ß-cell Replication Discovery Platform. J Vis Exp. 2016 07 16; (113). PMID: 27500720.
    Citations:    Fields:    Translation:HumansCells
  10. Zhao Z, Low YS, Armstrong NA, Ryu JH, Sun SA, Arvanites AC, Hollister-Lock J, Shah NH, Weir GC, Annes JP. Repurposing cAMP-modulating medications to promote ß-cell replication. Mol Endocrinol. 2014 Oct; 28(10):1682-97. PMID: 25083741.
    Citations: 9     Fields:    Translation:AnimalsCells
  11. Nichols RJ, New C, Annes JP. Adult tissue sources for new ß cells. Transl Res. 2014 Apr; 163(4):418-31. PMID: 24345765.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  12. Wei K, Piecewicz SM, McGinnis LM, Taniguchi CM, Wiegand SJ, Anderson K, Chan CW, Mulligan KX, Kuo D, Yuan J, Vallon M, Morton L, Lefai E, Simon MC, Maher JJ, Mithieux G, Rajas F, Annes J, McGuinness OP, Thurston G, Giaccia AJ, Kuo CJ. A liver Hif-2a-Irs2 pathway sensitizes hepatic insulin signaling and is modulated by Vegf inhibition. Nat Med. 2013 Oct; 19(10):1331-1337. PMID: 24037094.
    Citations: 33     Fields:    Translation:AnimalsCells
  13. Vaidya A, Underwood PC, Annes JP, Sun B, Williams GH, Forman JP, Williams JS. The influence of sodium- and calcium-regulatory hormone interventions on adipocytokines in obesity and diabetes. Metabolism. 2013 Apr; 62(4):539-47. PMID: 23142162.
    Citations: 3     Fields:    Translation:Humans
  14. Chen CA, Carolan PJ, Carolan PC, Annes JP. In vivo screening for secreted proteins that modulate glucose handling identifies interleukin-6 family members as potent hypoglycemic agents. PLoS One. 2012; 7(9):e44600. PMID: 22962620.
    Citations: 1     Fields:    Translation:AnimalsCells
  15. Bar-Lev A, Annes JP. Genetics of adrenocortical disease: an update. Curr Opin Endocrinol Diabetes Obes. 2012 Jun; 19(3):159-67. PMID: 22476103.
    Citations: 2     Fields:    Translation:Humans
  16. Annes JP, Ryu JH, Lam K, Carolan PJ, Utz K, Hollister-Lock J, Arvanites AC, Rubin LL, Weir G, Melton DA. Adenosine kinase inhibition selectively promotes rodent and porcine islet ß-cell replication. Proc Natl Acad Sci U S A. 2012 Mar 06; 109(10):3915-20. PMID: 22345561.
    Citations: 41     Fields:    Translation:AnimalsCells
  17. Volpicelli ER, Doyle L, Annes JP, Murray MF, Jacobsen E, Murphy GF, Saavedra AP. Erdheim-Chester disease presenting with cutaneous involvement: a case report and literature review. J Cutan Pathol. 2011 Mar; 38(3):280-5. PMID: 21143617.
    Citations: 6     Fields:    Translation:Humans
  18. Annes JP, Giovanni MA, Murray MF. Risks of presymptomatic direct-to-consumer genetic testing. N Engl J Med. 2010 Sep 16; 363(12):1100-1. PMID: 20843242.
    Citations: 15     Fields:    Translation:HumansPHPublic Health
  19. Annes JP, Chen Y, Munger JS, Rifkin DB. Integrin alphaVbeta6-mediated activation of latent TGF-beta requires the latent TGF-beta binding protein-1. J Cell Biol. 2004 Jun 07; 165(5):723-34. PMID: 15184403.
    Citations: 153     Fields:    Translation:AnimalsCells
  20. Annes J, Vassallo M, Munger JS, Rifkin DB. A genetic screen to identify latent transforming growth factor beta activators. Anal Biochem. 2004 Apr 01; 327(1):45-54. PMID: 15033509.
    Citations: 3     Fields:    Translation:AnimalsCells
  21. Krishnan S, Deora AB, Annes JP, Osoria J, Rifkin DB, Hajjar KA. Annexin II-mediated plasmin generation activates TGF-beta3 during epithelial-mesenchymal transformation in the developing avian heart. Dev Biol. 2004 Jan 01; 265(1):140-54. PMID: 14697359.
    Citations: 7     Fields:    Translation:Animals
  22. Annes JP, Munger JS, Rifkin DB. Making sense of latent TGFbeta activation. J Cell Sci. 2003 Jan 15; 116(Pt 2):217-24. PMID: 12482908.
    Citations: 491     Fields:    Translation:HumansAnimalsCells
  23. Chen Y, Dabovic B, Annes JP, Rifkin DB. Latent TGF-beta binding protein-3 (LTBP-3) requires binding to TGF-beta for secretion. FEBS Lett. 2002 Apr 24; 517(1-3):277-80. PMID: 12062452.
    Citations: 14     Fields:    Translation:HumansAnimalsCells
  24. Annes JP, Rifkin DB, Munger JS. The integrin alphaVbeta6 binds and activates latent TGFbeta3. FEBS Lett. 2002 Jan 30; 511(1-3):65-8. PMID: 11821050.
    Citations: 47     Fields:    Translation:AnimalsCells
  25. Gualandris A, Annes JP, Arese M, Noguera I, Jurukovski V, Rifkin DB. The latent transforming growth factor-beta-binding protein-1 promotes in vitro differentiation of embryonic stem cells into endothelium. Mol Biol Cell. 2000 Dec; 11(12):4295-308. PMID: 11102524.
    Citations: 18     Fields:    Translation:AnimalsCells
  26. Sun Z, Arendt CW, Ellmeier W, Schaeffer EM, Sunshine MJ, Gandhi L, Annes J, Petrzilka D, Kupfer A, Schwartzberg PL, Littman DR. PKC-theta is required for TCR-induced NF-kappaB activation in mature but not immature T lymphocytes. Nature. 2000 Mar 23; 404(6776):402-7. PMID: 10746729.
    Citations: 256     Fields:    Translation:HumansAnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.