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Shiqian Shen, Ph.D., M.D.


The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. RF1AG070141 (SHEN, SHIQIAN) Aug 1, 2021 - Jul 31, 2024
    Gut Microbiota Underlies the Heterogeneity of Aging Brain's Susceptibility to Postoperative Delirium
    Role: Principal Investigator
  2. R03 AG067947 (Shen, Shiqian) Sep 1, 2020 - Aug 31, 2022
    Pain Chronification during Aging
    Role: Principal Investigator
  3. R21AG065606 (ZHANG, YIYING) Sep 1, 2020 - Aug 31, 2022
    Microbiome Dysbiosis and Postoperative Delirium Pathogenesis
    Role: Co-Principal Investigator
  4. R03AG067947 (SHEN, SHIQIAN) Sep 1, 2020 - May 31, 2022
    Aging Promotes Pain Chronification through Changes in PGC-1alpha Expression and Interneuron Dysfunction
    Role: Principal Investigator
  5. R33NS116423 (SHEN, SHIQIAN) Jul 1, 2020 - Jun 30, 2023
    Development and Validation of a Clinically Relevant Animal Pain Model
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Chen C, Shen S. Trend analysis of drug overdose deaths before and during the COVID-19 pandemic. Am J Transl Res. 2022; 14(4):2685-2688. PMID: 35559402; PMCID: PMC9091116.
  2. Chen C, Shen S. A Data-driven, Dynamic and Flexible Approach to Safely Lifting Mask Mandate: A Proposal. Explor Res Hypothesis Med. 2022 Jun; 7(2):131-133. PMID: 35721376; PMCID: PMC9202658.
  3. Wang S, Yang Y, Suen A, Zhu J, Williams B, Hu J, Chen F, Kozar R, Shen S, Li Z, Jeyaram A, Jay SM, Zou L, Chao W. Role of extracellular microRNA-146a-5p in host innate immunity and bacterial sepsis. iScience. 2021 Dec 17; 24(12):103441. PMID: 34877498; PMCID: PMC8633977.
  4. Lan Y, Bai P, Liu Y, Afshar S, Striar R, Rattray AK, Meyer TN, Langan AG, Posner AM, Shen S, Tanzi RE, Zhang C, Wang C. Visualization of Receptor-Interacting Protein Kinase 1 (RIPK1) by Brain Imaging with Positron Emission Tomography. J Med Chem. 2021 10 28; 64(20):15420-15428. PMID: 34652135; PMCID: PMC8858444.
    Citations: 1     Fields:    Translation:AnimalsCells
  5. Zheng H, Duan G, Shen S, Zhang X. Association of Nutritional Risk Index With Postoperative Pain Outcomes in Elderly Patients Undergoing Gastrointestinal Surgeries: A Retrospective Cohort Study. Front Med (Lausanne). 2021; 8:535627. PMID: 34568349.
  6. Chen L, Deng H, Houle T, Zhang Y, Ahmed S, Zhang W, Sullivan S, Opalacz A, Roth S, Filatava EJ, Stabach K, Vo T, Malarick C, Kim H, You Z, Shen S, Mao J. Comparison between acupuncture therapy and gabapentin for chronic pain: a pilot study. Acupunct Med. 2021 Dec; 39(6):619-628. PMID: 34325532.
    Citations:    Fields:    Translation:Humans
  7. Gui S, Li J, Li M, Shi L, Lu J, Shen S, Li P, Mei W. Revealing the Cortical Glutamatergic Neural Activity During Burst Suppression by Simultaneous wide Field Calcium Imaging and Electroencephalography in Mice. Neuroscience. 2021 08 10; 469:110-124. PMID: 34237388.
    Citations:    Fields:    Translation:Animals
  8. Kemény LV, Robinson KC, Hermann AL, Walker DM, Regan S, Yew YW, Lai YC, Theodosakis N, Rivera PD, Ding W, Yang L, Beyer T, Loh YE, Lo JA, van der Sande AAJ, Sarnie W, Kotler D, Hsiao JJ, Su MY, Kato S, Kotler J, Bilbo SD, Chopra V, Salomon MP, Shen S, Hoon DSB, Asgari MM, Wakeman SE, Nestler EJ, Fisher DE. Vitamin D deficiency exacerbates UV/endorphin and opioid addiction. Sci Adv. 2021 06; 7(24). PMID: 34117054; PMCID: PMC8195487.
    Citations: 4     Fields:    Translation:HumansAnimals
  9. Robinson KC, Kemény LV, Fell GL, Hermann AL, Allouche J, Ding W, Yekkirala A, Hsiao JJ, Su MY, Theodosakis N, Kozak G, Takeuchi Y, Shen S, Berenyi A, Mao J, Woolf CJ, Fisher DE. Reduced MC4R signaling alters nociceptive thresholds associated with red hair. Sci Adv. 2021 04; 7(14). PMID: 33811065.
    Citations: 2     Fields:    Translation:Animals
  10. Ding W, You Z, Chen Q, Yang L, Doheny J, Zhou X, Li N, Wang S, Hu K, Chen L, Xia S, Wu X, Wang C, Zhang C, Chen L, Ritchie C, Huang P, Mao J, Shen S. Gut Microbiota Influences Neuropathic Pain Through Modulating Proinflammatory and Anti-inflammatory T Cells. Anesth Analg. 2021 04 01; 132(4):1146-1155. PMID: 32889847.
    Citations: 10     Fields:    Translation:AnimalsCells
  11. Xiong H, Mancini M, Gobert M, Shen S, Furtado GC, Lira SA, Parkhurst CN, Garambois V, Brengues M, Tadokoro CE, Trimarchi T, Gómez-López G, Singh A, Khiabanian H, Minuzzo S, Indraccolo S, Lobry C, Aifantis I, Herranz D, Lafaille JJ, Maraver A. Spleen plays a major role in DLL4-driven acute T-cell lymphoblastic leukemia. Theranostics. 2021; 11(4):1594-1608. PMID: 33408769; PMCID: PMC7778594.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  12. Zhou Y, Leung-Pitt Y, Deng H, Ren Y, You Z, Kem WR, Shen S, Zhang W, Mao J, Martyn JAJ. Nonopioid GTS-21 Mitigates Burn Injury Pain in Rats by Decreasing Spinal Cord Inflammatory Responses. Anesth Analg. 2021 01; 132(1):240-252. PMID: 33264122; PMCID: PMC7736563.
    Citations: 2     Fields:    Translation:Animals
  13. Cheng JZ, Bao MH, Shen S. A Case Report of a Successful Percutaneous Trial and Surgical Placement of a Spinal Cord Stimulator in a Patient With Severe Thoracolumbar Scoliosis. A A Pract. 2020 Jul; 14(9):e01270. PMID: 32909715.
    Citations:    Fields:    Translation:Humans
  14. You Z, Ding W, Doheny JT, Shen S, Yang J, Yang L, Chen L, Zhu S, Mao J. Methylphenidate and Morphine Combination Therapy in a Rat Model of Chronic Pain. Anesth Analg. 2020 02; 130(2):518-524. PMID: 31206430; PMCID: PMC7646954.
    Citations: 1     Fields:    Translation:Animals
  15. Liufu N, Liu L, Shen S, Jiang Z, Dong Y, Wang Y, Culley D, Crosby G, Cao M, Shen Y, Marcantonio E, Xie Z, Zhang Y. Anesthesia and surgery induce age-dependent changes in behaviors and microbiota. Aging (Albany NY). 2020 01 24; 12(2):1965-1986. PMID: 31974315.
    Citations: 13     Fields:    Translation:AnimalsCells
  16. Miao J, Zhou X, Ding W, You Z, Doheny J, Mei W, Chen Q, Mao J, Shen S. Proliferator-Activated Receptor-Gamma Coactivator-1a Haploinsufficiency Promotes Pain Chronification After Burn Injury. Anesth Analg. 2020 01; 130(1):240-247. PMID: 30829673; PMCID: PMC6752970.
    Citations: 1     Fields:    Translation:AnimalsCells
  17. Chen L, Deng H, Houle T, Zhang Y, Ahmed S, Zhang V, Sullivan S, Opalaze A, Roth S, Filatava EJ, St Clair K, Vo T, Malarick C, Kim H, You Z, Shen S, Mao J. A randomized trial to assess the immediate impact of acupuncture on quantitative sensory testing, pain, and functional status. Pain. 2019 11; 160(11):2456-2463. PMID: 31283555.
    Citations:    Fields:    Translation:Humans
  18. You Z, Ding W, Doheny JT, Yang J, Yang L, Lim G, Miao J, Chen L, Shen S, Mao J. Persistent Nociception Facilitates the Extinction of Morphine-Induced Conditioned Place Preference. Anesth Analg. 2019 09; 129(3):890-895. PMID: 31425234.
    Citations:    Fields:    Translation:Animals
  19. Huang B, Zhao J, Shen S, Li H, He KL, Shen GX, Mayer L, Unkeless J, Li D, Yuan Y, Zhang GM, Xiong H, Feng ZH. Editor's Note: Listeria monocytogenes Promotes Tumor Growth via Tumor Cell Toll-Like Receptor 2 Signaling. Cancer Res. 2019 Aug 15; 79(16):4306. PMID: 31416850.
    Citations:    Fields:    
  20. Yang L, Ding W, You Z, Yang J, Shen S, Doheny JT, Chen L, Li R, Mao J. Alleviation of trigeminal neuropathic pain by electroacupuncture: the role of hyperpolarization-activated cyclic nucleotide-gated channel protein expression in the Gasserian ganglion. Acupunct Med. 2019 06; 37(3):192-198. PMID: 30977667.
    Citations:    Fields:    Translation:HumansAnimals
  21. You Z, Ding W, Doheny JT, Yang J, Yang L, Lim G, Miao J, Chen L, Shen S, Mao J. Persistent Nociception Facilitates the Extinction of Morphine-Induced Conditioned Place Preference. Anesth Analg. 2018 Sep 27. PMID: 30273229.
    Citations:    Fields:    
  22. You Z, Zhang S, Shen S, Yang J, Ding W, Yang L, Lim G, Doheny JT, Tate S, Chen L, Mao J. Cognitive impairment in a rat model of neuropathic pain: role of hippocampal microtubule stability. Pain. 2018 Aug; 159(8):1518-1528. PMID: 29613911.
    Citations: 12     Fields:    Translation:AnimalsCells
  23. Liu Y, Ke X, Xiang G, Shen S, Mei W. A modification of ultrasound with nerve stimulation-guided lumbar plexus block in supine position for pediatric hip surgery. Paediatr Anaesth. 2018 07; 28(7):678-679. PMID: 30133910.
    Citations:    Fields:    Translation:Humans
  24. Gui L, Shen S, Mei W. Anaesthesia for chest wall reconstruction in a patient with Poland syndrome: CARE-compliant case report and literature review. BMC Anesthesiol. 2018 05 24; 18(1):57. PMID: 29793431.
    Citations:    Fields:    Translation:Humans
  25. Shen S, Ding W, Ahmed S, Hu R, Opalacz A, Roth S, You Z, Wotjkiewicz GR, Lim G, Chen L, Mao J, Chen JW, Zhang Y. Ultrasmall Superparamagnetic Iron Oxide Imaging Identifies Tissue and Nerve Inflammation in Pain Conditions. Pain Med. 2018 04 01; 19(4):686-692. PMID: 29177411; PMCID: PMC6659016.
    Citations: 1     Fields:    Translation:HumansAnimals
  26. Ding W, You Z, Shen S, Yang J, Lim G, Doheny JT, Zhu S, Zhang Y, Chen L, Mao J. Increased HCN Channel Activity in the Gasserian Ganglion Contributes to Trigeminal Neuropathic Pain. J Pain. 2018 06; 19(6):626-634. PMID: 29366880; PMCID: PMC5972061.
    Citations: 5     Fields:    Translation:Animals
  27. Hu K, Shen S, Zhang L. Herniation of crypts in hyperplastic polyp and sessile serrated adenoma: a prospective study. Am J Cancer Res. 2018; 8(1):144-153. PMID: 29416927; PMCID: PMC5794728.
    Citations: 2     
  28. Shen S, Lim G, You Z, Ding W, Huang P, Ran C, Doheny J, Caravan P, Tate S, Hu K, Kim H, McCabe M, Huang B, Xie Z, Kwon D, Chen L, Mao J. Gut microbiota is critical for the induction of chemotherapy-induced pain. Nat Neurosci. 2017 Sep; 20(9):1213-1216. PMID: 28714953; PMCID: PMC5575957.
    Citations: 68     Fields:    Translation:AnimalsCells
  29. Ding W, You Z, Shen S, Yang J, Lim G, Doheny JT, Chen L, Zhu S, Mao J. An Improved Rodent Model of Trigeminal Neuropathic Pain by Unilateral Chronic Constriction Injury of Distal Infraorbital Nerve. J Pain. 2017 08; 18(8):899-907. PMID: 28238950; PMCID: PMC5537008.
    Citations: 18     Fields:    Translation:Animals
  30. Ding W, You Z, Shen S, Chen L, Zhu S, Mao J. Inhibition of HCN channel activity in the thalamus attenuates chronic pain in rats. Neurosci Lett. 2016 Sep 19; 631:97-103. PMID: 27542339.
    Citations: 5     Fields:    Translation:Animals
  31. Hanna GM, Fishman I, Edwards DA, Shen S, Kram C, Liu X, Shotwell M, Gilligan C. Development and Patient Satisfaction of a New Telemedicine Service for Pain Management at Massachusetts General Hospital to the Island of Martha's Vineyard. Pain Med. 2016 09; 17(9):1658-63. PMID: 27121891.
    Citations: 10     Fields:    Translation:Humans
  32. Zhang S, You Z, Wang S, Yang J, Yang L, Sun Y, Mi W, Yang L, McCabe MF, Shen S, Chen L, Mao J. Neuropeptide S modulates the amygdaloidal HCN activities (Ih) in rats: Implication in chronic pain. Neuropharmacology. 2016 06; 105:420-433. PMID: 26855147.
    Citations: 9     Fields:    Translation:AnimalsCells
  33. Shen S, Shin JJ, Strle K, McHugh G, Li X, Glickstein LJ, Drouin EE, Steere AC. Treg cell numbers and function in patients with antibiotic-refractory or antibiotic-responsive Lyme arthritis. Arthritis Rheum. 2010 Jul; 62(7):2127-37. PMID: 20506317; PMCID: PMC2913315.
    Citations: 36     Fields:    Translation:HumansCells
  34. Zou L, Feng Y, Chen YJ, Si R, Shen S, Zhou Q, Ichinose F, Scherrer-Crosbie M, Chao W. Toll-like receptor 2 plays a critical role in cardiac dysfunction during polymicrobial sepsis. Crit Care Med. 2010 May; 38(5):1335-42. PMID: 20228680; PMCID: PMC3997231.
    Citations: 44     Fields:    Translation:AnimalsCells
  35. Strle K, Drouin EE, Shen S, El Khoury J, McHugh G, Ruzic-Sabljic E, Strle F, Steere AC. Borrelia burgdorferi stimulates macrophages to secrete higher levels of cytokines and chemokines than Borrelia afzelii or Borrelia garinii. J Infect Dis. 2009 Dec 15; 200(12):1936-43. PMID: 19909078; PMCID: PMC2783242.
    Citations: 35     Fields:    Translation:HumansCells
  36. Leung MW, Shen S, Lafaille JJ. TCR-dependent differentiation of thymic Foxp3+ cells is limited to small clonal sizes. J Exp Med. 2009 Sep 28; 206(10):2121-30. PMID: 19737865.
    Citations: 76     Fields:    Translation:AnimalsCells
  37. Huang B, Zhao J, Lei Z, Shen S, Li D, Shen GX, Zhang GM, Feng ZH. miR-142-3p restricts cAMP production in CD4+CD25- T cells and CD4+CD25+ TREG cells by targeting AC9 mRNA. EMBO Rep. 2009 Feb; 10(2):180-5. PMID: 19098714; PMCID: PMC2637310.
    Citations: 136     Fields:    Translation:AnimalsCells
  38. Curotto de Lafaille MA, Kutchukhidze N, Shen S, Ding Y, Yee H, Lafaille JJ. Adaptive Foxp3+ regulatory T cell-dependent and -independent control of allergic inflammation. Immunity. 2008 Jul 18; 29(1):114-26. PMID: 18617425.
    Citations: 194     Fields:    Translation:AnimalsCells
  39. Cao Y, Zhao J, Lei Z, Shen S, Liu C, Li D, Liu J, Shen GX, Zhang GM, Feng ZH, Huang B. Local accumulation of FOXP3+ regulatory T cells: evidence for an immune evasion mechanism in patients with large condylomata acuminata. J Immunol. 2008 Jun 01; 180(11):7681-6. PMID: 18490771.
    Citations: 18     Fields:    Translation:HumansCells
  40. Ding Y, Shen S, Lino AC, Curotto de Lafaille MA, Lafaille JJ. Beta-catenin stabilization extends regulatory T cell survival and induces anergy in nonregulatory T cells. Nat Med. 2008 Feb; 14(2):162-9. PMID: 18246080.
    Citations: 113     Fields:    Translation:AnimalsCells
  41. Huang B, Zhao J, Shen S, Li H, He KL, Shen GX, Mayer L, Unkeless J, Li D, Yuan Y, Zhang GM, Xiong H, Feng ZH. Listeria monocytogenes promotes tumor growth via tumor cell toll-like receptor 2 signaling. Cancer Res. 2007 May 01; 67(9):4346-52. PMID: 17483348.
    Citations: 73     Fields:    Translation:HumansAnimalsCells
  42. Tadokoro CE, Shakhar G, Shen S, Ding Y, Lino AC, Maraver A, Lafaille JJ, Dustin ML. Regulatory T cells inhibit stable contacts between CD4+ T cells and dendritic cells in vivo. J Exp Med. 2006 Mar 20; 203(3):505-11. PMID: 16533880; PMCID: PMC2118249.
    Citations: 199     Fields:    Translation:AnimalsCells
  43. Shen S, Ding Y, Tadokoro CE, Olivares-Villagómez D, Camps-Ramírez M, Curotto de Lafaille MA, Lafaille JJ. Control of homeostatic proliferation by regulatory T cells. J Clin Invest. 2005 Dec; 115(12):3517-26. PMID: 16294223; PMCID: PMC1283941.
    Citations: 36     Fields:    Translation:AnimalsCells
  44. Curotto de Lafaille MA, Shen S, Olivares-Villagómez D, Camps-Ramírez M, Lafaille JJ. Do regulatory T cells play a role in the control of homeostatic proliferation? Int Rev Immunol. 2005 May-Aug; 24(3-4):269-84. PMID: 16036378.
    Citations: 5     Fields:    Translation:HumansCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.