Harvard Catalyst Profiles

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Jeevan Bahadur Gc, Ph.D.

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Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Stutzman MJ, Kim CSJ, Tester DJ, Hamrick SK, Dotzler SM, Giudicessi JR, Miotto MC, Gc JB, Frank J, Marks AR, Ackerman MJ. Characterization of N-terminal RYR2 variants outside CPVT1 hotspot regions using patient iPSCs reveal pathogenesis and therapeutic potential. Stem Cell Reports. 2022 09 13; 17(9):2023-2036. PMID: 35931078; PMCID: PMC9481874.
    Citations:    Fields:    Translation:HumansCells
  2. Shintaku J, Pernice WM, Eyaid W, Gc JB, Brown ZP, Juanola-Falgarona M, Torres-Torronteras J, Sommerville EW, Hellebrekers DM, Blakely EL, Donaldson A, van de Laar I, Leu CS, Marti R, Frank J, Tanji K, Koolen DA, Rodenburg RJ, Chinnery PF, Smeets HJM, Gorman GS, Bonnen PE, Taylor RW, Hirano M. RRM1 variants cause a mitochondrial DNA maintenance disorder via impaired de novo nucleotide synthesis. J Clin Invest. 2022 07 01; 132(13). PMID: 35617047; PMCID: PMC9246377.
    Citations:    Fields:    Translation:HumansCells
  3. Szlenk CT, Gc JB, Natesan S. Membrane-Facilitated Receptor Access and Binding Mechanisms of Long-Acting ß2-Adrenergic Receptor Agonists. Mol Pharmacol. 2021 10; 100(4):406-427. PMID: 34334369; PMCID: PMC8626642.
    Citations: 1     Fields:    Translation:HumansCells
  4. Espiritu MJ, Chen J, Yadav J, Larkin M, Pelletier RD, Chan JM, Gc JB, Natesan S, Harrelson JP. Mechanisms of Herb-Drug Interactions Involving Cinnamon and CYP2A6: Focus on Time-Dependent Inhibition by Cinnamaldehyde and 2-Methoxycinnamaldehyde. Drug Metab Dispos. 2020 10; 48(10):1028-1043. PMID: 32788161; PMCID: PMC7543486.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  5. Gc JB, Szlenk CT, Gao J, Dong X, Wang Z, Natesan S. Molecular Dynamics Simulations Provide Insight into the Loading Efficiency of Proresolving Lipid Mediators Resolvin D1 and D2 in Cell Membrane-Derived Nanovesicles. Mol Pharm. 2020 06 01; 17(6):2155-2164. PMID: 32374613; PMCID: PMC7313724.
    Citations: 7     Fields:    Translation:Cells
  6. Szlenk CT, Gc JB, Natesan S. Does the Lipid Bilayer Orchestrate Access and Binding of Ligands to Transmembrane Orthosteric/Allosteric Sites of G Protein-Coupled Receptors? Mol Pharmacol. 2019 11; 96(5):527-541. PMID: 30967440; PMCID: PMC6776015.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
  7. Pokharel SM, Shil NK, Gc JB, Colburn ZT, Tsai SY, Segovia JA, Chang TH, Bandyopadhyay S, Natesan S, Jones JCR, Bose S. Integrin activation by the lipid molecule 25-hydroxycholesterol induces a proinflammatory response. Nat Commun. 2019 04 01; 10(1):1482. PMID: 30931941; PMCID: PMC6443809.
    Citations: 17     Fields:    Translation:AnimalsCells
  8. Gerstman BS, Chapagain PP, Gc J, Steckmann T. Molecular Dynamics Simulations of Conformational Conversions in Transformer Proteins. Methods Mol Biol. 2019; 1958:297-311. PMID: 30945225.
    Citations:    Fields:    Translation:Cells
  9. Del Vecchio K, Frick CT, Gc JB, Oda SI, Gerstman BS, Saphire EO, Chapagain PP, Stahelin RV. A cationic, C-terminal patch and structural rearrangements in Ebola virus matrix VP40 protein control its interactions with phosphatidylserine. J Biol Chem. 2018 03 02; 293(9):3335-3349. PMID: 29348171; PMCID: PMC5836117.
    Citations: 16     Fields:    Translation:HumansCells
  10. Gc JB, Pokhrel R, Bhattarai N, Johnson KA, Gerstman BS, Stahelin RV, Chapagain PP. Graphene-VP40 interactions and potential disruption of the Ebola virus matrix filaments. Biochem Biophys Res Commun. 2017 11 04; 493(1):176-181. PMID: 28917841; PMCID: PMC5636687.
    Citations: 3     Fields:    Translation:Cells
  11. Gc JB, Gerstman BS, Chapagain PP. Membrane association and localization dynamics of the Ebola virus matrix protein VP40. Biochim Biophys Acta Biomembr. 2017 Oct; 1859(10):2012-2020. PMID: 28711356.
    Citations: 12     Fields:    Translation:Cells
  12. Bhattarai N, Gc JB, Gerstman BS, Stahelin RV, Chapagain PP. Plasma membrane association facilitates conformational changes in the Marburg virus protein VP40 dimer. RSC Adv. 2017 Apr 26; 7(37):22741-22748. PMID: 28580138; PMCID: PMC5436087.
    Citations: 6     
  13. Gc JB, Gerstman BS, Stahelin RV, Chapagain PP. The Ebola virus protein VP40 hexamer enhances the clustering of PI(4,5)P2 lipids in the plasma membrane. Phys Chem Chem Phys. 2016 Oct 19; 18(41):28409-28417. PMID: 27757455; PMCID: PMC5084917.
    Citations: 19     Fields:    Translation:Cells
  14. Gc JB, Johnson KA, Husby ML, Frick CT, Gerstman BS, Stahelin RV, Chapagain PP. Interdomain salt-bridges in the Ebola virus protein VP40 and their role in domain association and plasma membrane localization. Protein Sci. 2016 09; 25(9):1648-58. PMID: 27328459; PMCID: PMC5338242.
    Citations: 10     Fields:    Translation:HumansCells
  15. GC JB, Gerstman BS, Chapagain PP. The Role of the Interdomain Interactions on RfaH Dynamics and Conformational Transformation. J Phys Chem B. 2015 Oct 08; 119(40):12750-9. PMID: 26374226.
    Citations: 12     Fields:    Translation:Cells
  16. Gc JB, Bhandari YR, Gerstman BS, Chapagain PP. Molecular dynamics investigations of the a-helix to ß-barrel conformational transformation in the RfaH transcription factor. J Phys Chem B. 2014 May 15; 118(19):5101-8. PMID: 24758259.
    Citations: 13     Fields:    Translation:Cells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.