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Thomas Peter Stossel, M.D.


Dameshek Award
MD (Hon)
Thomas Prize
MD (Hon)
Louis M Sherwood Award
McGovern Medal

Stossel was educated at Princeton University and Harvard Medical School, trained in internal medicine at the Massachusetts General Hospital and in hematology at Boston Children’s and Peter Bent Brigham Hospitals. He was head of Hematology and Oncology at Massachusetts General Hospital from 1976 until 1991, Co-Director of the Hematology Division at Brigham & Women’s Hospital through 2006, and is currently Director of the Division of Translational Medicine and Senior Physician in Hematology at that hospital and American Cancer Society Professor of Medicine at Harvard Medical School.

From 1976-1980 he was a consultant to the US Department of State, investigating effects of microwaves on US Embassy personnel in Moscow, former USSR. Stossel’s basic research concerns fundamental mechanisms of cell motility. This research led to discoveries that may reduce critical care complications of major injury and impact platelet transfusion therapy. His policy interests concern physician and researcher interactions with private industry.

He was President of the American Society for Clinical Investigation and Editor in Chief of its Journal of Clinical Investigation, served as President of the American Society of Hematology and received its Dameshek and Thomas Awards. He has been elected to Membership in The National Academy of Sciences, The American Academy of Arts and Sciences, and the Institute of Medicine. He currently is Editor in Chief of Current Opinion in Hematology, a member of the Lasker Awards Jury, the Board of Directors of Velico Medical Corporation and founding scientist of BioAegis Therapeutics. He has been awarded honorary MD degrees from the Universities of Linköping (Sweden) and Geneva (Switzerland). Stossel has assisted his wife, Kerry Maguire DDS MSPH, in doing dental prevention and treatment in an urban orphanage and a remote rural village in Zambia, and they have established a 5013c foundation, Options for Children in Zambia. Stossel also has an Honorary Physician Position at University Teaching Hospital, Lusaka, Zambia, where he is working with Zambian physicians to create a sickle cell disease center.

The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R03TW000787 (STOSSEL, THOMAS PETER) Sep 30, 1997 - Jul 31, 2000
    Role: Principal Investigator
  2. R01HL054253 (STOSSEL, THOMAS PETER) Apr 1, 1995 - Feb 29, 2000
    Role: Principal Investigator
  3. P01DK050305 (ARNAOUT, M. AMIN) Sep 30, 1989 - Apr 30, 2005
    Role: Co-Principal Investigator
  4. P01AI028465 (ARNAOUT, M. AMIN) Sep 30, 1989 - Jul 31, 1995
    Role: Co-Principal Investigator
  5. T32HL007680 (STOSSEL, THOMAS PETER) Jul 1, 1989 - Jun 30, 2010
    Biology of Vascular, Lung and Blood Diseases
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Self WH, Wunderink RG, DiNubile MJ, Stossel TP, Levinson SL, Williams DJ, Anderson EJ, Bramley AM, Jain S, Edwards KM, Grijalva CG. Low Admission Plasma Gelsolin Concentrations Identify Community-acquired Pneumonia Patients at High Risk for Severe Outcomes. Clin Infect Dis. 2018 Dec 17. PMID: 30561561.
    Citations:    Fields:    
  2. Chunda-Liyoka C, Kumar AA, Sambo P, Lubinda F, Nchimba L, Humpton T, Okuku P, Miyanda C, Im J, Maguire K, Whitesides GM, Stossel TP. Application of a public health strategy to large-scale point-of-care screening for sickle cell disease in rural sub-Saharan Africa. Blood Adv. 2018 11 30; 2(Suppl 1):1-3. PMID: 30504185.
  3. Stossel TP. A guide to the anti-innovation "pharmaphobia" narrative for the aspiring innovator. Surgery. 2017 02; 161(2):305-307. PMID: 28096036.
    Citations:    Fields:    Translation:Humans
  4. Nadkarni NA, Rajakumar A, Mokhashi N, Burke SD, Rana S, Salahuddin S, Dang Q, Thadhani R, Krishnan R, Stossel TP, Karumanchi SA. Gelsolin is an endogenous inhibitor of syncytiotrophoblast extracellular vesicle shedding in pregnancy. Pregnancy Hypertens. 2016 Oct; 6(4):333-339. PMID: 27939478.
    Citations: 1     Fields:    Translation:HumansCells
  5. Barton D, Stossel TP. Pediatric Dentists' Knowledge Concerning the Physician Payments Sunshine Act and Their Predictions of its Effects on Their Interactions with the Industry and its Impact on Patient Care. Pediatr Dent. 2016 Mar-Apr; 38(2):122-6. PMID: 27097860.
    Citations:    Fields:    Translation:Humans
  6. Song M, He Q, Berk BA, Hartwig JH, Stossel TP, Nakamura F. An adventitious interaction of filamin A with RhoGDI2(Tyr153Glu). Biochem Biophys Res Commun. 2016 Jan 15; 469(3):659-64. PMID: 26707877.
    Citations: 1     Fields:    Translation:HumansCells
  7. Li-ChunHsieh K, Schob S, Zeller MW, Pulli B, Ali M, Wang C, Chiou TT, Tsang YM, Lee PS, Stossel TP, Chen JW. Gelsolin decreases actin toxicity and inflammation in murine multiple sclerosis. J Neuroimmunol. 2015 Oct 15; 287:36-42. PMID: 26439960.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  8. Yang Z, Chiou TT, Stossel TP, Kobzik L. Plasma gelsolin improves lung host defense against pneumonia by enhancing macrophage NOS3 function. Am J Physiol Lung Cell Mol Physiol. 2015 Jul 01; 309(1):L11-6. PMID: 25957291.
    Citations: 9     Fields:    Translation:AnimalsCells
  9. Kumar AA, Hennek JW, Smith BS, Kumar S, Beattie P, Jain S, Rolland JP, Stossel TP, Chunda-Liyoka C, Whitesides GM. From the bench to the field in low-cost diagnostics: two case studies. Angew Chem Int Ed Engl. 2015 May 11; 54(20):5836-53. PMID: 25914299.
    Citations: 7     Fields:    Translation:Humans
  10. Stossel TP, Barton DW, Stell LK. Response to clarifying the costs of conflicts of interest. Int J Clin Pract. 2015 Mar; 69(3):385-6. PMID: 25727804.
    Citations:    Fields:    Translation:Humans
  11. Kumar AA, Chunda-Liyoka C, Hennek JW, Mantina H, Lee SY, Patton MR, Sambo P, Sinyangwe S, Kankasa C, Chintu C, Brugnara C, Stossel TP, Whitesides GM. Evaluation of a density-based rapid diagnostic test for sickle cell disease in a clinical setting in Zambia. PLoS One. 2014; 9(12):e114540. PMID: 25490722.
    Citations: 9     Fields:    Translation:HumansCells
  12. Gómez-Moutón C, Fischer T, Peregil RM, Jiménez-Baranda S, Stossel TP, Nakamura F, Mañes S. Filamin A interaction with the CXCR4 third intracellular loop regulates endocytosis and signaling of WT and WHIM-like receptors. Blood. 2015 Feb 12; 125(7):1116-25. PMID: 25355818.
    Citations: 3     Fields:    Translation:HumansCells
  13. Nakamura F, Song M, Hartwig JH, Stossel TP. Documentation and localization of force-mediated filamin A domain perturbations in moving cells. Nat Commun. 2014 Aug 14; 5:4656. PMID: 25120197.
    Citations: 3     Fields:    Translation:AnimalsCells
  14. Barton D, Stossel T, Stell L. After 20 years, industry critics bury skeptics, despite empirical vacuum. Int J Clin Pract. 2014 Jun; 68(6):666-73. PMID: 24837089.
    Citations: 3     Fields:    Translation:Humans
  15. Weber MA, Fonseca R, Stossel TP. In response: the ethics and value of professional medical writing assistance. Endocr Pract. 2013 Mar-Apr; 19(2):379-80. PMID: 23512399.
    Citations:    Fields:    Translation:Humans
  16. Chen H, Chandrasekar S, Sheetz MP, Stossel TP, Nakamura F, Yan J. Mechanical perturbation of filamin A immunoglobulin repeats 20-21 reveals potential non-equilibrium mechanochemical partner binding function. Sci Rep. 2013; 3:1642. PMID: 23571456.
    Citations: 12     Fields:    Translation:Cells
  17. Weber MA, Black HR, Fonseca R, Garber J, Gonzalez-Campoy JM, Kimmelstiel C, Markowitz AB, Nakayama D, Stell LK, Stossel TP. Association of Clinical Researchers and Educators a statement on relationships between physicians and industry. Endocr Pract. 2012 Nov-Dec; 18(6):1029-37. PMID: 22982801.
    Citations:    Fields:    Translation:Humans
  18. Stossel TP, Stell LK. Commenting on ten recommendations for closing the credibility gap in reporting industry-sponsored clinical research. Mayo Clin Proc. 2012 Sep; 87(9):925-6; author reply 926. PMID: 22958997.
    Citations:    Fields:    Translation:Humans
  19. Lesko R, Scott S, Stossel TP. Bias in high-tier medical journals concerning physician-academic relationships with industry. Nat Biotechnol. 2012 Apr 10; 30(4):320-2. PMID: 22491278.
    Citations: 1     Fields:    Translation:Humans
  20. Ehrlicher AJ, Nakamura F, Hartwig JH, Weitz DA, Stossel TP. Mechanical strain in actin networks regulates FilGAP and integrin binding to filamin A. Nature. 2011 Sep 18; 478(7368):260-3. PMID: 21926999.
    Citations: 105     Fields:    Translation:HumansAnimalsCells
  21. Stossel TP, Stell LK. Time to 'walk the walk' about industry ties to enhance health. Nat Med. 2011 Apr; 17(4):437-8. PMID: 21475240.
    Citations: 2     Fields:    Translation:Humans
  22. Nakamura F, Stossel TP, Hartwig JH. The filamins: organizers of cell structure and function. Cell Adh Migr. 2011 Mar-Apr; 5(2):160-9. PMID: 21169733.
    Citations: 128     Fields:    Translation:HumansAnimalsCells
  23. Stell LK, Stossel TP. Another dip into the muddy waters of COI. Am J Bioeth. 2011 Jan; 11(1):49-50. PMID: 21240813.
    Citations:    Fields:    Translation:Humans
  24. Kasza KE, Broedersz CP, Koenderink GH, Lin YC, Messner W, Millman EA, Nakamura F, Stossel TP, Mackintosh FC, Weitz DA. Actin filament length tunes elasticity of flexibly cross-linked actin networks. Biophys J. 2010 Aug 09; 99(4):1091-100. PMID: 20712992.
    Citations: 15     Fields:    Translation:HumansAnimalsCells
  25. Stossel TP. Filamins and the potential of complexity. Cell Cycle. 2010 Apr 15; 9(8):1463. PMID: 20421719.
    Citations: 4     Fields:    Translation:HumansCells
  26. Playford MP, Nurminen E, Pentikäinen OT, Milgram SL, Hartwig JH, Stossel TP, Nakamura F. Cystic fibrosis transmembrane conductance regulator interacts with multiple immunoglobulin domains of filamin A. J Biol Chem. 2010 May 28; 285(22):17156-65. PMID: 20351098.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  27. Stossel TP. The AAMC exhibits the behavior it condemns. Am J Bioeth. 2010 Jan; 10(1):26-7. PMID: 20077333.
    Citations:    Fields:    Translation:Humans
  28. Stossel TP. AACE and ACRE: Harmony of Interests. Endocr Pract. 2009 Nov-Dec; 15(7):671. PMID: 20044323.
    Citations:    Fields:    Translation:Humans
  29. Koenderink GH, Dogic Z, Nakamura F, Bendix PM, MacKintosh FC, Hartwig JH, Stossel TP, Weitz DA. An active biopolymer network controlled by molecular motors. Proc Natl Acad Sci U S A. 2009 Sep 08; 106(36):15192-7. PMID: 19667200.
    Citations: 72     Fields:    Translation:Cells
  30. Kasza KE, Nakamura F, Hu S, Kollmannsberger P, Bonakdar N, Fabry B, Stossel TP, Wang N, Weitz DA. Filamin A is essential for active cell stiffening but not passive stiffening under external force. Biophys J. 2009 May 20; 96(10):4326-35. PMID: 19450503.
    Citations: 42     Fields:    Translation:HumansCells
  31. Kasza KE, Koenderink GH, Lin YC, Broedersz CP, Messner W, Nakamura F, Stossel TP, MacKintosh FC, Weitz DA. Nonlinear elasticity of stiff biopolymers connected by flexible linkers. Phys Rev E Stat Nonlin Soft Matter Phys. 2009 Apr; 79(4 Pt 1):041928. PMID: 19518277.
    Citations: 19     Fields:    Translation:HumansCells
  32. Lee PS, Sampath K, Karumanchi SA, Tamez H, Bhan I, Isakova T, Gutierrez OM, Wolf M, Chang Y, Stossel TP, Thadhani R. Plasma gelsolin and circulating actin correlate with hemodialysis mortality. J Am Soc Nephrol. 2009 May; 20(5):1140-8. PMID: 19389844.
    Citations: 29     Fields:    Translation:Humans
  33. Nakamura F, Heikkinen O, Pentikäinen OT, Osborn TM, Kasza KE, Weitz DA, Kupiainen O, Permi P, Kilpeläinen I, Ylänne J, Hartwig JH, Stossel TP. Molecular basis of filamin A-FilGAP interaction and its impairment in congenital disorders associated with filamin A mutations. PLoS One. 2009; 4(3):e4928. PMID: 19293932.
    Citations: 32     Fields:    Translation:HumansCells
  34. Lee PS, Patel SR, Christiani DC, Bajwa E, Stossel TP, Waxman AB. Plasma gelsolin depletion and circulating actin in sepsis: a pilot study. PLoS One. 2008; 3(11):e3712. PMID: 19002257.
    Citations: 19     Fields:    Translation:Humans
  35. Osborn TM, Verdrengh M, Stossel TP, Tarkowski A, Bokarewa M. Decreased levels of the gelsolin plasma isoform in patients with rheumatoid arthritis. Arthritis Res Ther. 2008; 10(5):R117. PMID: 18822171.
    Citations: 18     Fields:    Translation:Humans
  36. Stossel TP. The discovery of statins. Cell. 2008 Sep 19; 134(6):903-5. PMID: 18805080.
    Citations: 6     Fields:    Translation:HumansAnimals
  37. Stossel TP. Response to AMA's Council on Ethical and Judicial Affairs draft report on "Ethical guidance for physicians and the profession with respect to industry support for professional education in medicine". Medscape J Med. 2008 Jun 12; 10(6):137. PMID: 18679553.
    Citations: 2     Fields:    Translation:Humans
  38. Stossel TP. Has the hunt for conflicts of interest gone too far? Yes. BMJ. 2008 Mar 01; 336(7642):476. PMID: 18309999.
    Citations: 7     Fields:    
  39. Stossel TP. A biopsy of financial conflicts of interest in medicine. Surgery. 2008 Feb; 143(2):193-8. PMID: 18242335.
    Citations: 3     Fields:    Translation:Humans
  40. Nakamura F, Osborn TM, Hartemink CA, Hartwig JH, Stossel TP. Structural basis of filamin A functions. J Cell Biol. 2007 Dec 03; 179(5):1011-25. PMID: 18056414.
    Citations: 103     Fields:    Translation:HumansCells
  41. Weins A, Schlondorff JS, Nakamura F, Denker BM, Hartwig JH, Stossel TP, Pollak MR. Disease-associated mutant alpha-actinin-4 reveals a mechanism for regulating its F-actin-binding affinity. Proc Natl Acad Sci U S A. 2007 Oct 09; 104(41):16080-5. PMID: 17901210.
    Citations: 50     Fields:    Translation:HumansAnimalsCells
  42. Stossel TP. Divergent views on managing clinical conflicts of interest. Mayo Clin Proc. 2007 Aug; 82(8):1013-4; author reply 1014-5. PMID: 17673071.
    Citations: 5     Fields:    Translation:Humans
  43. Stossel TP. Conflicts of interest in dermatology: more than skin deep? J Invest Dermatol. 2007 Aug; 127(8):1829-30. PMID: 17632551.
    Citations:    Fields:    Translation:Humans
  44. Lee PS, Waxman AB, Cotich KL, Chung SW, Perrella MA, Stossel TP. Plasma gelsolin is a marker and therapeutic agent in animal sepsis. Crit Care Med. 2007 Mar; 35(3):849-55. PMID: 17205019.
    Citations: 35     Fields:    Translation:AnimalsCells
  45. Babic AM, Josefsson EC, Bergmeier W, Wagner DD, Kaufman RM, Silberstein LE, Stossel TP, Hartwig JH, Hoffmeister KM. In vitro function and phagocytosis of galactosylated platelet concentrates after long-term refrigeration. Transfusion. 2007 Mar; 47(3):442-51. PMID: 17319824.
    Citations: 12     Fields:    Translation:HumansCells
  46. Stossel TP. Overregulation of conflicts hinders medical progress. Cleve Clin J Med. 2007 Mar; 74 Suppl 2:S14-5; discussion S16-22. PMID: 17469469.
    Citations: 1     Fields:    Translation:Humans
  47. Stossel TP. Regulation of financial conflicts of interest in medical practice and medical research: a damaging solution in search of a problem. Perspect Biol Med. 2007; 50(1):54-71. PMID: 17259676.
    Citations: 7     Fields:    Translation:Humans
  48. Osborn TM, Dahlgren C, Hartwig JH, Stossel TP. Modifications of cellular responses to lysophosphatidic acid and platelet-activating factor by plasma gelsolin. Am J Physiol Cell Physiol. 2007 Apr; 292(4):C1323-30. PMID: 17135294.
    Citations: 29     Fields:    Translation:HumansCells
  49. Stossel TP, Fenteany G, Hartwig JH. Cell surface actin remodeling. J Cell Sci. 2006 Aug 15; 119(Pt 16):3261-4. PMID: 16899816.
    Citations: 21     Fields:    Translation:HumansCells
  50. Ohta Y, Hartwig JH, Stossel TP. FilGAP, a Rho- and ROCK-regulated GAP for Rac binds filamin A to control actin remodelling. Nat Cell Biol. 2006 Aug; 8(8):803-14. PMID: 16862148.
    Citations: 145     Fields:    Translation:HumansAnimalsCells
  51. Stossel T, Shaywitz D. What's wrong with money in science. Washington Post. 2006 Jul 02; B3. PMID: 16838447.
    Citations:    Translation:Humans
  52. Gardel ML, Nakamura F, Hartwig J, Crocker JC, Stossel TP, Weitz DA. Stress-dependent elasticity of composite actin networks as a model for cell behavior. Phys Rev Lett. 2006 Mar 03; 96(8):088102. PMID: 16606229.
    Citations: 40     Fields:    Translation:AnimalsCells
  53. Lee PS, Drager LR, Stossel TP, Moore FD, Rogers SO. Relationship of plasma gelsolin levels to outcomes in critically ill surgical patients. Ann Surg. 2006 Mar; 243(3):399-403. PMID: 16495706.
    Citations: 24     Fields:    Translation:Humans
  54. Gardel ML, Nakamura F, Hartwig JH, Crocker JC, Stossel TP, Weitz DA. Prestressed F-actin networks cross-linked by hinged filamins replicate mechanical properties of cells. Proc Natl Acad Sci U S A. 2006 Feb 07; 103(6):1762-7. PMID: 16446458.
    Citations: 109     Fields:    Translation:HumansAnimalsCells
  55. Nakamura F, Pudas R, Heikkinen O, Permi P, Kilpeläinen I, Munday AD, Hartwig JH, Stossel TP, Ylänne J. The structure of the GPIb-filamin A complex. Blood. 2006 Mar 01; 107(5):1925-32. PMID: 16293600.
    Citations: 59     Fields:    Translation:HumansCells
  56. Di Nardo A, Cicchetti G, Falet H, Hartwig JH, Stossel TP, Kwiatkowski DJ. Arp2/3 complex-deficient mouse fibroblasts are viable and have normal leading-edge actin structure and function. Proc Natl Acad Sci U S A. 2005 Nov 08; 102(45):16263-8. PMID: 16254049.
    Citations: 23     Fields:    Translation:AnimalsCells
  57. Stossel TP. Regulating academic-industrial research relationships--solving problems or stifling progress? N Engl J Med. 2005 Sep 08; 353(10):1060-5. PMID: 16148294.
    Citations: 27     Fields:    Translation:Humans
  58. Nakamura F, Hartwig JH, Stossel TP, Szymanski PT. Ca2+ and calmodulin regulate the binding of filamin A to actin filaments. J Biol Chem. 2005 Sep 16; 280(37):32426-33. PMID: 16030015.
    Citations: 26     Fields:    Translation:HumansAnimalsCells
  59. Josefsson EC, Gebhard HH, Stossel TP, Hartwig JH, Hoffmeister KM. The macrophage alphaMbeta2 integrin alphaM lectin domain mediates the phagocytosis of chilled platelets. J Biol Chem. 2005 May 06; 280(18):18025-32. PMID: 15741160.
    Citations: 19     Fields:    Translation:HumansAnimalsCells
  60. Insel PA, Kornfeld S, Majerus PW, Marks AR, Marks PA, Relman AS, Scharschmidt BF, Stossel TP, Varki AP, Weiss SJ, Wilson JD. Blasts from the past. J Clin Invest. 2004 Oct; 114(8):1017-33. PMID: 15489944.
    Citations: 1     Fields:    Translation:HumansAnimals
  61. Valeri CR, Ragno G, Marks PW, Kuter DJ, Rosenberg RD, Stossel TP. Effect of thrombopoietin alone and a combination of cytochalasin B and ethylene glycol bis(beta-aminoethyl ether) N,N'-tetraacetic acid-AM on the survival and function of autologous baboon platelets stored at 4 degrees C for as long as 5 days. Transfusion. 2004 Jun; 44(6):865-70. PMID: 15157253.
    Citations: 3     Fields:    Translation:AnimalsCells
  62. Woo MS, Ohta Y, Rabinovitz I, Stossel TP, Blenis J. Ribosomal S6 kinase (RSK) regulates phosphorylation of filamin A on an important regulatory site. Mol Cell Biol. 2004 Apr; 24(7):3025-35. PMID: 15024089.
    Citations: 59     Fields:    Translation:HumansAnimalsCells
  63. Hoffmeister KM, Josefsson EC, Isaac NA, Clausen H, Hartwig JH, Stossel TP. Glycosylation restores survival of chilled blood platelets. Science. 2003 Sep 12; 301(5639):1531-4. PMID: 12970565.
    Citations: 44     Fields:    Translation:HumansAnimalsCells
  64. Stossel TP, Hartwig JH. Filling gaps in signaling to actin cytoskeletal remodeling. Dev Cell. 2003 Apr; 4(4):444-5. PMID: 12689583.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  65. Hoffmeister KM, Felbinger TW, Falet H, Denis CV, Bergmeier W, Mayadas TN, von Andrian UH, Wagner DD, Stossel TP, Hartwig JH. The clearance mechanism of chilled blood platelets. Cell. 2003 Jan 10; 112(1):87-97. PMID: 12526796.
    Citations: 76     Fields:    Translation:HumansAnimalsCells
  66. Falet H, Hoffmeister KM, Neujahr R, Italiano JE, Stossel TP, Southwick FS, Hartwig JH. Importance of free actin filament barbed ends for Arp2/3 complex function in platelets and fibroblasts. Proc Natl Acad Sci U S A. 2002 Dec 24; 99(26):16782-7. PMID: 12464680.
    Citations: 25     Fields:    Translation:HumansCells
  67. Vadlamudi RK, Li F, Adam L, Nguyen D, Ohta Y, Stossel TP, Kumar R. Filamin is essential in actin cytoskeletal assembly mediated by p21-activated kinase 1. Nat Cell Biol. 2002 Sep; 4(9):681-90. PMID: 12198493.
    Citations: 110     Fields:    Translation:HumansCells
  68. DiNubile MJ, Stossel TP, Ljunghusen OC, Ferrara JL, Antin JH. Prognostic implications of declining plasma gelsolin levels after allogeneic stem cell transplantation. Blood. 2002 Dec 15; 100(13):4367-71. PMID: 12393536.
    Citations: 16     Fields:    Translation:Humans
  69. Nakamura F, Osborn E, Janmey PA, Stossel TP. Comparison of filamin A-induced cross-linking and Arp2/3 complex-mediated branching on the mechanics of actin filaments. J Biol Chem. 2002 Mar 15; 277(11):9148-54. PMID: 11786548.
    Citations: 29     Fields:    Translation:Cells
  70. Christofidou-Solomidou M, Scherpereel A, Solomides CC, Christie JD, Stossel TP, Goelz S, DiNubile MJ. Recombinant plasma gelsolin diminishes the acute inflammatory response to hyperoxia in mice. J Investig Med. 2002 Jan; 50(1):54-60. PMID: 11813829.
    Citations: 17     Fields:    Translation:HumansAnimals
  71. Flanagan LA, Chou J, Falet H, Neujahr R, Hartwig JH, Stossel TP. Filamin A, the Arp2/3 complex, and the morphology and function of cortical actin filaments in human melanoma cells. J Cell Biol. 2001 Nov 12; 155(4):511-7. PMID: 11706047.
    Citations: 68     Fields:    Translation:HumansCells
  72. Hussain NK, Jenna S, Glogauer M, Quinn CC, Wasiak S, Guipponi M, Antonarakis SE, Kay BK, Stossel TP, Lamarche-Vane N, McPherson PS. Endocytic protein intersectin-l regulates actin assembly via Cdc42 and N-WASP. Nat Cell Biol. 2001 Oct; 3(10):927-32. PMID: 11584276.
    Citations: 116     Fields:    Translation:HumansAnimalsCells
  73. Cunningham CC, Vegners R, Bucki R, Funaki M, Korde N, Hartwig JH, Stossel TP, Janmey PA. Cell permeant polyphosphoinositide-binding peptides that block cell motility and actin assembly. J Biol Chem. 2001 Nov 16; 276(46):43390-9. PMID: 11533030.
    Citations: 35     Fields:    Translation:HumansAnimalsCells
  74. Hoffmeister KM, Falet H, Toker A, Barkalow KL, Stossel TP, Hartwig JH. Mechanisms of cold-induced platelet actin assembly. J Biol Chem. 2001 Jul 06; 276(27):24751-9. PMID: 11328807.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  75. Stossel TP, Condeelis J, Cooley L, Hartwig JH, Noegel A, Schleicher M, Shapiro SS. Filamins as integrators of cell mechanics and signalling. Nat Rev Mol Cell Biol. 2001 Feb; 2(2):138-45. PMID: 11252955.
    Citations: 277     Fields:    Translation:Cells
  76. Janmey PA, Shah JV, Tang JX, Stossel TP. Actin filament networks. Results Probl Cell Differ. 2001; 32:181-99. PMID: 11131831.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  77. Bellanger JM, Astier C, Sardet C, Ohta Y, Stossel TP, Debant A. The Rac1- and RhoG-specific GEF domain of Trio targets filamin to remodel cytoskeletal actin. Nat Cell Biol. 2000 Dec; 2(12):888-92. PMID: 11146652.
    Citations: 67     Fields:    Translation:HumansCells
  78. Glogauer M, Hartwig J, Stossel T. Two pathways through Cdc42 couple the N-formyl receptor to actin nucleation in permeabilized human neutrophils. J Cell Biol. 2000 Aug 21; 150(4):785-96. PMID: 10953003.
    Citations: 28     Fields:    Translation:HumansCells
  79. Fenteany G, Janmey PA, Stossel TP. Signaling pathways and cell mechanics involved in wound closure by epithelial cell sheets. Curr Biol. 2000 Jul 13; 10(14):831-8. PMID: 10899000.
    Citations: 88     Fields:    Translation:AnimalsCells
  80. Goetzl EJ, Lee H, Azuma T, Stossel TP, Turck CW, Karliner JS. Gelsolin binding and cellular presentation of lysophosphatidic acid. J Biol Chem. 2000 May 12; 275(19):14573-8. PMID: 10799543.
    Citations: 32     Fields:    Translation:AnimalsCells
  81. Goetzl EJ, Lee H, Dolezalova H, Kalli KR, Conover CA, Hu YL, Azuma T, Stossel TP, Karliner JS, Jaffe RB. Mechanisms of lysolipid phosphate effects on cellular survival and proliferation. Ann N Y Acad Sci. 2000 Apr; 905:177-87. PMID: 10818453.
    Citations: 12     Fields:    Translation:HumansCells
  82. Stossel TP. On being paid not to work for the men of impressive but easy affairs. Trans Am Clin Climatol Assoc. 2000; 111:85-90; discussion 90-2. PMID: 10881334.
    Citations:    Fields:    
  83. Stossel TP. Do strict regulations governing academic-industrial relationships in biomedical research and education make sense? Curr Opin Hematol. 1999 Nov; 6(6):363-4. PMID: 10546787.
    Citations: 1     Fields:    Translation:Humans
  84. Tang JX, Janmey PA, Stossel TP, Ito T. Thiol oxidation of actin produces dimers that enhance the elasticity of the F-actin network. Biophys J. 1999 Apr; 76(4):2208-15. PMID: 10096915.
    Citations: 10     Fields:    Translation:AnimalsCells
  85. Ohta Y, Suzuki N, Nakamura S, Hartwig JH, Stossel TP. The small GTPase RalA targets filamin to induce filopodia. Proc Natl Acad Sci U S A. 1999 Mar 02; 96(5):2122-8. PMID: 10051605.
    Citations: 123     Fields:    Translation:HumansAnimalsCells
  86. Fujita H, Allen PG, Janmey PA, Azuma T, Kwiatkowski DJ, Stossel TP, Kuzumaki N. Induction of apoptosis by gelsolin truncates. Ann N Y Acad Sci. 1999; 886:217-20. PMID: 10667223.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  87. Stossel TP, Hartwig JH, Janmey PA, Kwiatkowski DJ. Cell crawling two decades after Abercrombie. Biochem Soc Symp. 1999; 65:267-80. PMID: 10320944.
    Citations: 7     Fields:    Translation:Cells
  88. Stossel TP. The free market and scientific research benefit from private and public support. Curr Opin Hematol. 1998 Nov; 5(6):367-8. PMID: 9814640.
    Citations:    Fields:    
  89. Xu J, Schwarz WH, Käs JA, Stossel TP, Janmey PA, Pollard TD. Mechanical properties of actin filament networks depend on preparation, polymerization conditions, and storage of actin monomers. Biophys J. 1998 May; 74(5):2731-40. PMID: 9591697.
    Citations: 26     Fields:    Translation:AnimalsCells
  90. Janmey PA, Stossel TP, Allen PG. Deconstructing gelsolin: identifying sites that mimic or alter binding to actin and phosphoinositides. Chem Biol. 1998 Apr; 5(4):R81-5. PMID: 9571211.
    Citations: 3     Fields:    Translation:Cells
  91. Azuma T, Witke W, Stossel TP, Hartwig JH, Kwiatkowski DJ. Gelsolin is a downstream effector of rac for fibroblast motility. EMBO J. 1998 Mar 02; 17(5):1362-70. PMID: 9482733.
    Citations: 62     Fields:    Translation:HumansAnimalsCells
  92. Fujita H, Allen PG, Janmey PA, Azuma T, Kwiatkowski DJ, Stossel TP, Furu-uchi K, Kuzumaki N. Characterization of gelsolin truncates that inhibit actin depolymerization by severing activity of gelsolin and cofilin. Eur J Biochem. 1997 Sep 15; 248(3):834-9. PMID: 9342236.
    Citations: 2     Fields:    Translation:Cells
  93. Marti A, Luo Z, Cunningham C, Ohta Y, Hartwig J, Stossel TP, Kyriakis JM, Avruch J. Actin-binding protein-280 binds the stress-activated protein kinase (SAPK) activator SEK-1 and is required for tumor necrosis factor-alpha activation of SAPK in melanoma cells. J Biol Chem. 1997 Jan 31; 272(5):2620-8. PMID: 9006895.
    Citations: 37     Fields:    Translation:HumansAnimalsCells
  94. Hartwig JH, Kung S, Kovacsovics T, Janmey PA, Cantley LC, Stossel TP, Toker A. D3 phosphoinositides and outside-in integrin signaling by glycoprotein IIb-IIIa mediate platelet actin assembly and filopodial extension induced by phorbol 12-myristate 13-acetate. J Biol Chem. 1996 Dec 20; 271(51):32986-93. PMID: 8955143.
    Citations: 20     Fields:    Translation:HumansCells
  95. Bunn HF, Stossel TP, Forget BG, Stamatoyannopoulos G, Weatherall DJ. Pitfalls of genetic testing. N Engl J Med. 1996 Oct 17; 335(16):1236; author reply 1236-7. PMID: 8999325.
    Citations:    Fields:    Translation:Humans
  96. Sheils CA, Käs J, Travassos W, Allen PG, Janmey PA, Wohl ME, Stossel TP. Actin filaments mediate DNA fiber formation in chronic inflammatory airway disease. Am J Pathol. 1996 Mar; 148(3):919-27. PMID: 8774146.
    Citations: 17     Fields:    Translation:Humans
  97. Stossel TP. Rethinking research management practices. Curr Opin Hematol. 1996 Jan; 3(1):1-2. PMID: 9372044.
    Citations:    Fields:    
  98. Hartwig JH, Bokoch GM, Carpenter CL, Janmey PA, Taylor LA, Toker A, Stossel TP. Thrombin receptor ligation and activated Rac uncap actin filament barbed ends through phosphoinositide synthesis in permeabilized human platelets. Cell. 1995 Aug 25; 82(4):643-53. PMID: 7664343.
    Citations: 146     Fields:    Translation:HumansCells
  99. Fujita H, Laham LE, Janmey PA, Kwiatkowski DJ, Stossel TP, Banno Y, Nozawa Y, Müllauer L, Ishizaki A, Kuzumaki N. Functions of [His321]gelsolin isolated from a flat revertant of ras-transformed cells. Eur J Biochem. 1995 May 01; 229(3):615-20. PMID: 7758454.
    Citations: 3     Fields:    Translation:AnimalsCells
  100. Witke W, Sharpe AH, Hartwig JH, Azuma T, Stossel TP, Kwiatkowski DJ. Hemostatic, inflammatory, and fibroblast responses are blunted in mice lacking gelsolin. Cell. 1995 Apr 07; 81(1):41-51. PMID: 7720072.
    Citations: 112     Fields:    Translation:AnimalsCells
  101. Stossel TP. The lost opportunity of the Health Research Fund. Commentary. Curr Opin Hematol. 1995 Jan; 2(1):1-2. PMID: 9371965.
    Citations:    Fields:    
  102. Janmey PA, Hvidt S, Käs J, Lerche D, Maggs A, Sackmann E, Schliwa M, Stossel TP. The mechanical properties of actin gels. Elastic modulus and filament motions. J Biol Chem. 1994 Dec 23; 269(51):32503-13. PMID: 7798252.
    Citations: 51     Fields:    Translation:AnimalsCells
  103. Stossel TP. The machinery of cell crawling. Sci Am. 1994 Sep; 271(3):54-5, 58-63. PMID: 8091190.
    Citations: 15     Fields:    Translation:HumansAnimalsCells
  104. Stossel TP. The E. Donnall Thomas Lecture, 1993. The machinery of blood cell movements. Blood. 1994 Jul 15; 84(2):367-79. PMID: 8025265.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  105. Vasconcellos CA, Allen PG, Wohl ME, Drazen JM, Janmey PA, Stossel TP. Reduction in viscosity of cystic fibrosis sputum in vitro by gelsolin. Science. 1994 Feb 18; 263(5149):969-71. PMID: 8310295.
    Citations: 29     Fields:    Translation:Humans
  106. Stossel TP. A proposal to mobilize public opinion in support of the National Institutes of Health. Commentary. Curr Opin Hematol. 1994 Jan; 1(1):1-3. PMID: 9371252.
    Citations:    Fields:    
  107. Stossel TP. Funding clinical studies. Pharos Alpha Omega Alpha Honor Med Soc. 1994; 57(3):46. PMID: 7938197.
    Citations:    Fields:    Translation:Humans
  108. Stossel TP. On the crawling of animal cells. Science. 1993 May 21; 260(5111):1086-94. PMID: 8493552.
    Citations: 208     Fields:    Translation:AnimalsCells
  109. Katakami Y, Katakami N, Janmey PA, Hartwig JH, Stossel TP. Isolation of the phosphatidylinositol 4-monophosphate dissociable high-affinity profilin-actin complex. Biochim Biophys Acta. 1992 Jul 31; 1122(2):123-35. PMID: 1322701.
    Citations: 2     Fields:    Translation:Animals
  110. Ito T, Suzuki A, Stossel TP. Regulation of water flow by actin-binding protein-induced actin gelatin. Biophys J. 1992 May; 61(5):1301-5. PMID: 1318095.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  111. Cunningham CC, Gorlin JB, Kwiatkowski DJ, Hartwig JH, Janmey PA, Byers HR, Stossel TP. Actin-binding protein requirement for cortical stability and efficient locomotion. Science. 1992 Jan 17; 255(5042):325-7. PMID: 1549777.
    Citations: 164     Fields:    Translation:HumansCells
  112. Ohta Y, Stossel TP, Hartwig JH. Ligand-sensitive binding of actin-binding protein to immunoglobulin G Fc receptor I (Fc gamma RI). Cell. 1991 Oct 18; 67(2):275-82. PMID: 1833070.
    Citations: 21     Fields:    Translation:HumansCells
  113. Cunningham CC, Stossel TP, Kwiatkowski DJ. Enhanced motility in NIH 3T3 fibroblasts that overexpress gelsolin. Science. 1991 Mar 08; 251(4998):1233-6. PMID: 1848726.
    Citations: 68     Fields:    Translation:HumansAnimalsCells
  114. Janmey PA, Hvidt S, Oster GF, Lamb J, Stossel TP, Hartwig JH. Effect of ATP on actin filament stiffness. Nature. 1990 Sep 06; 347(6288):95-9. PMID: 2168523.
    Citations: 24     Fields:    Translation:AnimalsCells
  115. Gorlin JB, Yamin R, Egan S, Stewart M, Stossel TP, Kwiatkowski DJ, Hartwig JH. Human endothelial actin-binding protein (ABP-280, nonmuscle filamin): a molecular leaf spring. J Cell Biol. 1990 Sep; 111(3):1089-105. PMID: 2391361.
    Citations: 139     Fields:    Translation:HumansCells
  116. Hartwig JH, Brown D, Ausiello DA, Stossel TP, Orci L. Polarization of gelsolin and actin binding protein in kidney epithelial cells. J Histochem Cytochem. 1990 Aug; 38(8):1145-53. PMID: 2164058.
    Citations: 3     Fields:    Translation:AnimalsCells
  117. Howard T, Chaponnier C, Yin H, Stossel T. Gelsolin-actin interaction and actin polymerization in human neutrophils. J Cell Biol. 1990 Jun; 110(6):1983-91. PMID: 2161855.
    Citations: 21     Fields:    Translation:HumansCells
  118. Janmey PA, Hvidt S, Lamb J, Stossel TP. Resemblance of actin-binding protein/actin gels to covalently crosslinked networks. Nature. 1990 May 03; 345(6270):89-92. PMID: 2158633.
    Citations: 61     Fields:    
  119. Stossel TP, Stossel SC. Declining American representation in leading clinical-research journals. N Engl J Med. 1990 Mar 15; 322(11):739-42. PMID: 2308603.
    Citations: 21     Fields:    
  120. Stossel TP. From signal to pseudopod. How cells control cytoplasmic actin assembly. J Biol Chem. 1989 Nov 05; 264(31):18261-4. PMID: 2681192.
    Citations: 108     Fields:    Translation:Cells
  121. Southwick FS, Howard TH, Holbrook T, Anderson DC, Stossel TP, Arnaout MA. The relationship between CR3 deficiency and neutrophil actin assembly. Blood. 1989 May 15; 73(7):1973-9. PMID: 2523744.
    Citations: 4     Fields:    Translation:HumansCells
  122. Janmey PA, Stossel TP. Gelsolin-polyphosphoinositide interaction. Full expression of gelsolin-inhibiting function by polyphosphoinositides in vesicular form and inactivation by dilution, aggregation, or masking of the inositol head group. J Biol Chem. 1989 Mar 25; 264(9):4825-31. PMID: 2538463.
    Citations: 41     Fields:    Translation:HumansAnimalsCells
  123. Hartwig JH, Chambers KA, Stossel TP. Association of gelsolin with actin filaments and cell membranes of macrophages and platelets. J Cell Biol. 1989 Feb; 108(2):467-79. PMID: 2537317.
    Citations: 34     Fields:    Translation:HumansCells
  124. Southwick FS, Dabiri GA, Stossel TP. Neutrophil actin dysfunction is a genetic disorder associated with partial impairment of neutrophil actin assembly in three family members. J Clin Invest. 1988 Nov; 82(5):1525-31. PMID: 3183050.
    Citations: 9     Fields:    Translation:HumansCells
  125. Janmey PA, Hvidt S, Peetermans J, Lamb J, Ferry JD, Stossel TP. Viscoelasticity of F-actin and F-actin/gelsolin complexes. Biochemistry. 1988 Oct 18; 27(21):8218-27. PMID: 2852957.
    Citations: 21     Fields:    Translation:HumansAnimalsCells
  126. Ezzell RM, Kenney DM, Egan S, Stossel TP, Hartwig JH. Localization of the domain of actin-binding protein that binds to membrane glycoprotein Ib and actin in human platelets. J Biol Chem. 1988 Sep 15; 263(26):13303-9. PMID: 3138234.
    Citations: 11     Fields:    Translation:AnimalsCells
  127. Lind SE, Smith DB, Janmey PA, Stossel TP. Depression of gelsolin levels and detection of gelsolin-actin complexes in plasma of patients with acute lung injury. Am Rev Respir Dis. 1988 Aug; 138(2):429-34. PMID: 2848430.
    Citations: 21     Fields:    Translation:Humans
  128. Stossel TP. "PLATO" on line: biomedical communication in the computer age. Perspect Biol Med. 1988; 32(1):1-11. PMID: 3200677.
    Citations:    Fields:    
  129. Stossel TP. Clinical investigation and JAMA. JAMA. 1987 Dec 11; 258(22):3298. PMID: 3682119.
    Citations:    Fields:    
  130. Stossel TP. Brave new medicine. Presidential address to the American Society for Clinical Investigation, San Diego, California, 2 May 1987. J Clin Invest. 1987 Oct; 80(4):921-7. PMID: 3654980.
    Citations:    Fields:    Translation:Humans
  131. Janmey PA, Iida K, Yin HL, Stossel TP. Polyphosphoinositide micelles and polyphosphoinositide-containing vesicles dissociate endogenous gelsolin-actin complexes and promote actin assembly from the fast-growing end of actin filaments blocked by gelsolin. J Biol Chem. 1987 Sep 05; 262(25):12228-36. PMID: 3040735.
    Citations: 62     Fields:    
  132. Lind SE, Janmey PA, Chaponnier C, Herbert TJ, Stossel TP. Reversible binding of actin to gelsolin and profilin in human platelet extracts. J Cell Biol. 1987 Aug; 105(2):833-42. PMID: 3040771.
    Citations: 48     Fields:    Translation:HumansCells
  133. Ito T, Zaner KS, Stossel TP. Nonideality of volume flows and phase transitions of F-actin solutions in response to osmotic stress. Biophys J. 1987 May; 51(5):745-53. PMID: 3593872.
    Citations: 16     Fields:    
  134. Janmey PA, Stossel TP. Modulation of gelsolin function by phosphatidylinositol 4,5-bisphosphate. Nature. 1987 Jan 22-28; 325(6102):362-4. PMID: 3027569.
    Citations: 142     Fields:    Translation:HumansAnimalsCells
  135. Chaponnier C, Yin HL, Stossel TP. Reversibility of gelsolin/actin interaction in macrophages. Evidence of Ca2+-dependent and Ca2+-independent pathways. J Exp Med. 1987 Jan 01; 165(1):97-106. PMID: 3025333.
    Citations: 22     Fields:    Translation:AnimalsCells
  136. Kwiatkowski DJ, Stossel TP, Orkin SH, Mole JE, Colten HR, Yin HL. Plasma and cytoplasmic gelsolins are encoded by a single gene and contain a duplicated actin-binding domain. Nature. 1986 Oct 2-8; 323(6087):455-8. PMID: 3020431.
    Citations: 123     Fields:    Translation:HumansCells
  137. Janmey PA, Stossel TP. Kinetics of actin monomer exchange at the slow growing ends of actin filaments and their relation to the elongation of filaments shortened by gelsolin. J Muscle Res Cell Motil. 1986 Oct; 7(5):446-54. PMID: 3025252.
    Citations: 11     Fields:    Translation:AnimalsCells
  138. Lind SE, Smith DB, Janmey PA, Stossel TP. Role of plasma gelsolin and the vitamin D-binding protein in clearing actin from the circulation. J Clin Invest. 1986 Sep; 78(3):736-42. PMID: 3018044.
    Citations: 32     Fields:    Translation:HumansAnimals
  139. Janmey PA, Peetermans J, Zaner KS, Stossel TP, Tanaka T. Structure and mobility of actin filaments as measured by quasielastic light scattering, viscometry, and electron microscopy. J Biol Chem. 1986 Jun 25; 261(18):8357-62. PMID: 3013849.
    Citations: 46     Fields:    Translation:AnimalsCells
  140. Janmey PA, Stossel TP, Lind SE. Sequential binding of actin monomers to plasma gelsolin and its inhibition by vitamin D-binding protein. Biochem Biophys Res Commun. 1986 Apr 14; 136(1):72-9. PMID: 3010978.
    Citations: 14     Fields:    Translation:Animals
  141. Stossel TP. The actin system and the rheology of peripheral cytoplasm. Biorheology. 1986; 23(6):621-31. PMID: 3651578.
    Citations: 1     Fields:    Translation:HumansCells
  142. Janmey PA, Lind SE, Yin HL, Stossel TP. Effects of semi-dilute actin solutions on the mobility of fibrin protofibrils during clot formation. Biochim Biophys Acta. 1985 Aug 16; 841(2):151-8. PMID: 2990570.
    Citations: 7     Fields:    Translation:HumansAnimals
  143. Janmey PA, Chaponnier C, Lind SE, Zaner KS, Stossel TP, Yin HL. Interactions of gelsolin and gelsolin-actin complexes with actin. Effects of calcium on actin nucleation, filament severing, and end blocking. Biochemistry. 1985 Jul 02; 24(14):3714-23. PMID: 2994715.
    Citations: 54     Fields:    Translation:AnimalsCells
  144. Weitberg AB, Weitzman SA, Clark EP, Stossel TP. Effects of antioxidants on oxidant-induced sister chromatid exchange formation. J Clin Invest. 1985 Jun; 75(6):1835-41. PMID: 3924956.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  145. Stossel TP. Reviewer status and review quality. Experience of the Journal of Clinical Investigation. N Engl J Med. 1985 Mar 07; 312(10):658-9. PMID: 3974642.
    Citations: 4     Fields:    
  146. Stossel TP, Chaponnier C, Ezzell RM, Hartwig JH, Janmey PA, Kwiatkowski DJ, Lind SE, Smith DB, Southwick FS, Yin HL, et al. Nonmuscle actin-binding proteins. Annu Rev Cell Biol. 1985; 1:353-402. PMID: 3030380.
    Citations: 154     Fields:    Translation:AnimalsCells
  147. Weitzman SA, Stossel TP, Harmon DC, Daniels G, Maloof F, Ridgway EC. Antineutrophil autoantibodies in Graves' disease. Implications of thyrotropin binding to neutrophils. J Clin Invest. 1985 Jan; 75(1):119-23. PMID: 3838096.
    Citations: 7     Fields:    Translation:HumansCells
  148. Bennett JP, Zaner KS, Stossel TP. Isolation and some properties of macrophage alpha-actinin: evidence that it is not an actin gelling protein. Biochemistry. 1984 Oct 09; 23(21):5081-6. PMID: 6498177.
    Citations: 27     Fields: