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Eric Peter Schmidt, M.D.

Title
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Department
Address
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Biography
Dartmouth College, Hanover, NHBA06/1997Government
University of Pittsburgh, Pittsburgh, PAMD06/2001Medicine
Johns Hopkins Hospital, Baltimore, MD06/2004Internal Medicine Residency
Johns Hopkins Hospital, Baltimore, MD06/2006Assistant Chief of Service
Johns Hopkins Hospital, Baltimore, MD06/2009Pulmonary/Critical Care Fellowship
2001
Mayer A. Green Award in Internal Medicine
2001
Medical Alumni Association Recognition Award
2013
Giles F. Filley Memorial Award
2013
Outstanding Early Career Scholar
2014
Academic Excellence Award
2015
Early Career Research Achievement Award
2019
Fellow of the American Thoracic Society

Overview
Our laboratory focuses on the mechanisms underlying sepsis and septic organ injury. We are particularly interested in the role of glycosaminoglycans (such as heparan sulfate) in the onset, propagation, and resolution of septic lung, kidney, and brain injury. Using novel glycoanalytical approaches, we seek to find new insights into the mechanistic and phenotypic heterogeneity of critical illness.

Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R13HL152479 (SCHMIDT, ERIC PETER) Jul 1, 2020 - Jun 30, 2021
    NIH
    ARDS in the 21st Century: New Insights into Clinical and Mechanistic Heterogeneity
    Role: Principal Investigator
  2. R01HL149422 (SHAPIRO, NATHAN I) Sep 1, 2019 - May 31, 2023
    NIH
    The Impact of Fluid Resuscitation on Glycocalyx Degradation in Septic Shock
    Role: Co-Principal Investigator
  3. W81XWH1810682 (Schmidt, Eric Peter) Sep 15, 2018 - Sep 14, 2022
    CDMRP/DOD
    Shedding of alveolar heparan sulfate mediates epithelial dysfunction in experimental and human ARDS
    Role: Principal Investigator
  4. R01GM125095 (SCHMIDT, ERIC PETER) Jul 15, 2017 - May 31, 2021
    NIH
    Targeting circulating endothelial glycocalyx fragments to reduce septic encephalopathy
    Role: Principal Investigator
  5. W81XWH1610183 (Schmidt, Eric Peter) Jul 1, 2016 - Dec 31, 2017
    CDMRP/DOD
    Reinforcing the endothelial surface layer to prevent lung injury
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Keogh RA, Haeberle AL, Langouët-Astrié CJ, Kavanaugh JS, Schmidt EP, Moore GD, Horswill AR, Doran KS. Group B Streptococcus adaptation promotes survival in a hyperinflammatory diabetic wound environment. Sci Adv. 2022 Nov 11; 8(45):eadd3221. PMID: 36367946.
    Citations:    Fields:    
  2. Bartlett NW, Bastarache JA, Kuebler WM, Schmidt EP. Call for Papers: "In it for the long haul: understanding the lasting impact of COVID-19 on lung health and disease". Am J Physiol Lung Cell Mol Physiol. 2022 Nov 08. PMID: 36346147.
    Citations:    Fields:    
  3. Vohwinkel CU, Burns N, Coit E, Yuan X, Vladar EK, Sul C, Schmidt EP, Carmeliet P, Stenmark K, Nozik ES, Tuder RM, Eltzschig HK. HIF1A-dependent induction of alveolar epithelial PFKFB3 dampens acute lung injury. JCI Insight. 2022 Nov 03. PMID: 36326834.
    Citations:    Fields:    
  4. Martin TR, Zemans RL, Ware LB, Schmidt EP, Riches DWH, Bastarache L, Calfee CS, Desai TJ, Herold S, Hough CL, Looney MR, Matthay MA, Meyer N, Parikh SM, Stevens T, Thompson BT. New Insights into Clinical and Mechanistic Heterogeneity of the Acute Respiratory Distress Syndrome: Summary of the Aspen Lung Conference 2021. Am J Respir Cell Mol Biol. 2022 09; 67(3):284-308. PMID: 35679511; PMCID: PMC9447141.
    Citations:    Fields:    
  5. Sullivan RC, Schmidt EP. Procalcitonin: A Mediator of Microvascular Dysfunction during Critical Illness. Am J Respir Crit Care Med. 2022 08 15; 206(4):375-376. PMID: 35704285.
    Citations:    Fields:    Translation:Humans
  6. Li M, Ong CY, Langouët-Astrié CJ, Tan L, Verma A, Yang Y, Zhang X, Shah DK, Schmidt EP, Xu D. Heparan sulfate-dependent RAGE oligomerization is indispensable for pathophysiological functions of RAGE. Elife. 2022 02 09; 11. PMID: 35137686.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  7. Kulkarni HS, Lee JS, Bastarache JA, Kuebler WM, Downey GP, Albaiceta GM, Altemeier WA, Artigas A, Bates JHT, Calfee CS, Dela Cruz CS, Dickson RP, Englert JA, Everitt JI, Fessler MB, Gelman AE, Gowdy KM, Groshong SD, Herold S, Homer RJ, Horowitz JC, Hsia CCW, Kurahashi K, Laubach VE, Looney MR, Lucas R, Mangalmurti NS, Manicone AM, Martin TR, Matalon S, Matthay MA, McAuley DF, McGrath-Morrow SA, Mizgerd JP, Montgomery SA, Moore BB, Noël A, Perlman CE, Reilly JP, Schmidt EP, Skerrett SJ, Suber TL, Summers C, Suratt BT, Takata M, Tuder R, Uhlig S, Witzenrath M, Zemans RL, Matute-Bello G. Update on the Features and Measurements of Experimental Acute Lung Injury in Animals: An Official American Thoracic Society Workshop Report. Am J Respir Cell Mol Biol. 2022 02; 66(2):e1-e14. PMID: 35103557; PMCID: PMC8845128.
    Citations: 1     Fields:    Translation:Animals
  8. Rizzo AN, Haeger SM, Oshima K, Yang Y, Wallbank AM, Jin Y, Lettau M, McCaig LA, Wickersham NE, McNeil JB, Zakharevich I, McMurtry SA, Langouët-Astrié CJ, Kopf KW, Voelker DR, Hansen KC, Shaver CM, Kerchberger VE, Peterson RA, Kuebler WM, Ochs M, Veldhuizen RA, Smith BJ, Ware LB, Bastarache JA, Schmidt EP. Alveolar epithelial glycocalyx degradation mediates surfactant dysfunction and contributes to acute respiratory distress syndrome. JCI Insight. 2022 01 25; 7(2). PMID: 34874923; PMCID: PMC8855818.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  9. Bauer C, Piani F, Banks M, Ordoñez FA, de Lucas-Collantes C, Oshima K, Schmidt EP, Zakharevich I, Segarra A, Martinez C, Roncal-Jimenez C, Satchell SC, Bjornstad P, Lucia MS, Blaine J, Thurman JM, Johnson RJ, Cara-Fuentes G. Minimal Change Disease Is Associated With Endothelial Glycocalyx Degradation and Endothelial Activation. Kidney Int Rep. 2022 Apr; 7(4):797-809. PMID: 35497798.
    Citations: 3     
  10. Sullivan RC, Rockstrom MD, Schmidt EP, Hippensteel JA. Endothelial glycocalyx degradation during sepsis: Causes and consequences. Matrix Biol Plus. 2021 Dec; 12:100094. PMID: 34917925.
    Citations: 4     
  11. Shimoda LA, Bai C, Bartlett NW, Bastarache JA, Feghali-Bostwick C, Gunst SJ, Kuebler WM, Schmidt EP, Morty RE. Promoting our early career members at AJP-Lung: the Editorial Board Fellowship Program and the Next Generation Physiologist Highlights section at our Journal. Am J Physiol Lung Cell Mol Physiol. 2021 11 01; 321(5):L844-L846. PMID: 34585617; PMCID: PMC8616620.
    Citations:    Fields:    
  12. Barrett CD, Moore HB, Moore EE, Wang J, Hajizadeh N, Biffl WL, Lottenberg L, Patel PR, Truitt MS, McIntyre RC, Bull TM, Ammons LA, Ghasabyan A, Chandler J, Douglas IS, Schmidt EP, Moore PK, Wright FL, Ramdeo R, Borrego R, Rueda M, Dhupa A, McCaul DS, Dandan T, Sarkar PK, Khan B, Sreevidya C, McDaniel C, Grossman Verner HM, Pearcy C, Anez-Bustillos L, Baedorf-Kassis EN, Jhunjhunwala R, Shaefi S, Capers K, Banner-Goodspeed V, Talmor DS, Sauaia A, Yaffe MB. Study of Alteplase for Respiratory Failure in SARS-CoV-2 COVID-19: A Vanguard Multicenter, Rapidly Adaptive, Pragmatic, Randomized Controlled Trial. Chest. 2022 03; 161(3):710-727. PMID: 34592318; PMCID: PMC8474873.
    Citations: 9     Fields:    Translation:HumansCellsPHPublic HealthCTClinical Trials
  13. Beitler JR, Thompson BT, Baron RM, Bastarache JA, Denlinger LC, Esserman L, Gong MN, LaVange LM, Lewis RJ, Marshall JC, Martin TR, McAuley DF, Meyer NJ, Moss M, Reineck LA, Rubin E, Schmidt EP, Standiford TJ, Ware LB, Wong HR, Aggarwal NR, Calfee CS. Advancing precision medicine for acute respiratory distress syndrome. Lancet Respir Med. 2022 01; 10(1):107-120. PMID: 34310901; PMCID: PMC8302189.
    Citations: 10     Fields:    Translation:Humans
  14. Shimoda LA, Bai C, Bartlett NW, Bastarache JA, Feghali-Bostwick C, Kuebler WM, Prakash YS, Schmidt EP, Morty RE. Announcing the Editorial Board Fellowship Program of the American Journal of Physiology-Lung Cellular and Molecular Physiology. Am J Physiol Lung Cell Mol Physiol. 2021 07 01; 321(1):L116-L118. PMID: 34105373.
    Citations: 1     Fields:    Translation:Humans
  15. Oshima K, King SI, McMurtry SA, Schmidt EP. Endothelial Heparan Sulfate Proteoglycans in Sepsis: The Role of the Glycocalyx. Semin Thromb Hemost. 2021 Apr; 47(3):274-282. PMID: 33794552.
    Citations: 3     Fields:    Translation:HumansCells
  16. Douglas IS, Rosenthal CA, Swanson DD, Hiller T, Oakes J, Bach J, Whelchel C, Pickering J, George T, Kearns M, Hanley M, Mould K, Roark S, Mansoori J, Mehta A, Schmidt EP, Neumeier A. Safety and Outcomes of Prolonged Usual Care Prone Position Mechanical Ventilation to Treat Acute Coronavirus Disease 2019 Hypoxemic Respiratory Failure. Crit Care Med. 2021 03 01; 49(3):490-502. PMID: 33405409.
    Citations: 17     Fields:    Translation:Humans
  17. LaRiviere WB, Han X, Oshima K, McMurtry SA, Linhardt RJ, Schmidt EP. Detection of Glycosaminoglycans by Polyacrylamide Gel Electrophoresis and Silver Staining. J Vis Exp. 2021 02 25; (168). PMID: 33720131.
    Citations:    Fields:    Translation:AnimalsCells
  18. Rizzo AN, Schmidt EP. ABO blood type: a window into the genetics of acute respiratory distress syndrome susceptibility. J Clin Invest. 2021 01 04; 131(1). PMID: 33141764.
    Citations:    Fields:    Translation:HumansCells
  19. Baron RM, Christman JW, Liu KD, Matthay MA, Self WH, McVerry BJ, Hite RD, Paine R, Wurfel MM, Shapiro NI, Adams PW, Schmidt EP, Ringwood N. Monitoring Research Blood Sampling in Critically Ill Patients: Avoiding Iatrogenic Anemia. Am J Respir Crit Care Med. 2020 09 15; 202(6):885-887. PMID: 32357306; PMCID: PMC7491392.
    Citations: 3     Fields:    Translation:HumansPHPublic Health
  20. Hippensteel JA, LaRiviere WB, Colbert JF, Langouët-Astrié CJ, Schmidt EP. Heparin as a therapy for COVID-19: current evidence and future possibilities. Am J Physiol Lung Cell Mol Physiol. 2020 08 01; 319(2):L211-L217. PMID: 32519894.
    Citations: 67     Fields:    Translation:HumansCellsPHPublic Health
  21. LaRivière WB, Liao S, McMurtry SA, Oshima K, Han X, Zhang F, Yan S, Haeger SM, Ransom M, Bastarache JA, Linhardt RJ, Schmidt EP, Yang Y. Alveolar heparan sulfate shedding impedes recovery from bleomycin-induced lung injury. Am J Physiol Lung Cell Mol Physiol. 2020 06 01; 318(6):L1198-L1210. PMID: 32320623.
    Citations: 10     Fields:    Translation:AnimalsCells
  22. LaRivière WB, Schmidt EP. Using the Extremes of Human Inflammation to Understand the Transcriptional Control of IL-18. Am J Respir Crit Care Med. 2020 03 01; 201(5):503-504. PMID: 31898912.
    Citations:    Fields:    Translation:HumansCells
  23. Gómez BI, Dubick MA, Schmidt EP, Shupp JW, Burmeister DM. Plasma and Urinary Glycosaminoglycans as Evidence for Endotheliopathy in a Swine Burn Model. J Surg Res. 2020 04; 248:28-37. PMID: 31841734.
    Citations: 3     Fields:    Translation:AnimalsCells
  24. Files DC, Hume PS, Krall J, Montemayor K, Schmidt EP, King LS. Grant Writing for Clinicians in Training: An Important Career Development Exercise. Chest. 2020 04; 157(4):932-935. PMID: 31730834.
    Citations:    Fields:    Translation:Humans
  25. Oshima K, Han X, Ouyang Y, El Masri R, Yang Y, Haeger SM, McMurtry SA, Lane TC, Davizon-Castillo P, Zhang F, Yue X, Vivès RR, Linhardt RJ, Schmidt EP. Loss of endothelial sulfatase-1 after experimental sepsis attenuates subsequent pulmonary inflammatory responses. Am J Physiol Lung Cell Mol Physiol. 2019 11 01; 317(5):L667-L677. PMID: 31461325.
    Citations: 4     Fields:    Translation:AnimalsCells
  26. Hippensteel JA, Uchimido R, Tyler PD, Burke RC, Han X, Zhang F, McMurtry SA, Colbert JF, Lindsell CJ, Angus DC, Kellum JA, Yealy DM, Linhardt RJ, Shapiro NI, Schmidt EP. Intravenous fluid resuscitation is associated with septic endothelial glycocalyx degradation. Crit Care. 2019 07 23; 23(1):259. PMID: 31337421; PMCID: PMC6652002.
    Citations: 40     Fields:    Translation:HumansCells
  27. Kwiecinski JM, Crosby HA, Valotteau C, Hippensteel JA, Nayak MK, Chauhan AK, Schmidt EP, Dufrêne YF, Horswill AR. Staphylococcus aureus adhesion in endovascular infections is controlled by the ArlRS-MgrA signaling cascade. PLoS Pathog. 2019 05; 15(5):e1007800. PMID: 31116795.
    Citations: 17     Fields:    Translation:HumansAnimalsCells
  28. Liao S, Eickelberg O, Schmidt EP, Yang Y. Direct Intrabronchial Administration to Improve the Selective Agent Deposition Within the Mouse Lung. J Vis Exp. 2019 05 20; (147). PMID: 31157786.
    Citations: 1     Fields:    Translation:Animals
  29. Zhang X, Han X, Xia K, Xu Y, Yang Y, Oshima K, Haeger SM, Perez MJ, McMurtry SA, Hippensteel JA, Ford JA, Herson PS, Liu J, Schmidt EP, Linhardt RJ. Circulating heparin oligosaccharides rapidly target the hippocampus in sepsis, potentially impacting cognitive functions. Proc Natl Acad Sci U S A. 2019 05 07; 116(19):9208-9213. PMID: 31010931.
    Citations: 21     Fields:    Translation:HumansAnimals
  30. Hippensteel JA, Anderson BJ, Orfila JE, McMurtry SA, Dietz RM, Su G, Ford JA, Oshima K, Yang Y, Zhang F, Han X, Yu Y, Liu J, Linhardt RJ, Meyer NJ, Herson PS, Schmidt EP. Circulating heparan sulfate fragments mediate septic cognitive dysfunction. J Clin Invest. 2019 04 01; 129(4):1779-1784. PMID: 30720464.
    Citations: 46     Fields:    Translation:Animals
  31. Uchimido R, Schmidt EP, Shapiro NI. The glycocalyx: a novel diagnostic and therapeutic target in sepsis. Crit Care. 2019 Jan 17; 23(1):16. PMID: 30654825; PMCID: PMC6337861.
    Citations: 136     Fields:    Translation:HumansCells
  32. Hippensteel JA, Shapiro NI, Schmidt EP. Challenging Dogma: The Value of Bolus Fluids in the Early Resuscitation of Hyperdynamic Sepsis. Am J Respir Crit Care Med. 2018 10 15; 198(8):981-983. PMID: 29940124.
    Citations: 1     Fields:    Translation:Animals
  33. LaRivière WB, Schmidt EP. The Pulmonary Endothelial Glycocalyx in ARDS: A Critical Role for Heparan Sulfate. Curr Top Membr. 2018; 82:33-52. PMID: 30360782.
    Citations: 21     Fields:    Translation:HumansCells
  34. Haeger SM, Liu X, Han X, McNeil JB, Oshima K, McMurtry SA, Yang Y, Ouyang Y, Zhang F, Nozik-Grayck E, Zemans RL, Tuder RM, Bastarache JA, Linhardt RJ, Schmidt EP. Epithelial Heparan Sulfate Contributes to Alveolar Barrier Function and Is Shed during Lung Injury. Am J Respir Cell Mol Biol. 2018 09; 59(3):363-374. PMID: 29584451; PMCID: PMC6189644.
    Citations: 15     Fields:    Translation:AnimalsCells
  35. Hippensteel JA, Schmidt EP. Sequestering Damage-associated Molecular Patterns in Critical Illness. A Novel Homeostatic Role for the Erythrocyte. Am J Respir Crit Care Med. 2018 02 15; 197(4):416-418. PMID: 29120664.
    Citations:    Fields:    Translation:HumansCells
  36. Yang Y, Hippensteel JA, Schmidt EP. Intravital Microscopy in the Mouse Lung. Methods Mol Biol. 2018; 1809:331-339. PMID: 29987798.
    Citations: 3     Fields:    Translation:Animals
  37. Oshima K, Haeger SM, Hippensteel JA, Herson PS, Schmidt EP. More than a biomarker: the systemic consequences of heparan sulfate fragments released during endothelial surface layer degradation (2017 Grover Conference Series). Pulm Circ. 2018 Jan-Mar; 8(1):2045893217745786. PMID: 29199903; PMCID: PMC5731723.
    Citations: 7     
  38. Zhang Y, Haeger SM, Yang Y, Dailey KL, Ford JA, Schmidt EP. Circulating Heparan Sulfate Fragments Attenuate Histone-Induced Lung Injury Independently of Histone Binding. Shock. 2017 12; 48(6):666-673. PMID: 28538085.
    Citations: 12     Fields:    Translation:Animals
  39. Neudecker V, Brodsky KS, Clambey ET, Schmidt EP, Packard TA, Davenport B, Standiford TJ, Weng T, Fletcher AA, Barthel L, Masterson JC, Furuta GT, Cai C, Blackburn MR, Ginde AA, Graner MW, Janssen WJ, Zemans RL, Evans CM, Burnham EL, Homann D, Moss M, Kreth S, Zacharowski K, Henson PM, Eltzschig HK. Neutrophil transfer of miR-223 to lung epithelial cells dampens acute lung injury in mice. Sci Transl Med. 2017 Sep 20; 9(408). PMID: 28931657.
    Citations: 82     Fields:    Translation:HumansAnimalsCells
  40. Rau AS, Reinikovaite V, Schmidt EP, Taraseviciene-Stewart L, Deleyiannis FW. Electronic Cigarettes Are as Toxic to Skin Flap Survival as Tobacco Cigarettes. Ann Plast Surg. 2017 Jul; 79(1):86-91. PMID: 28252546.
    Citations: 8     Fields:    Translation:AnimalsPHPublic Health
  41. Yang Y, Haeger SM, Suflita MA, Zhang F, Dailey KL, Colbert JF, Ford JA, Picon MA, Stearman RS, Lin L, Liu X, Han X, Linhardt RJ, Schmidt EP. Fibroblast Growth Factor Signaling Mediates Pulmonary Endothelial Glycocalyx Reconstitution. Am J Respir Cell Mol Biol. 2017 06; 56(6):727-737. PMID: 28187268; PMCID: PMC5516293.
    Citations: 36     Fields:    Translation:AnimalsCells
  42. Colbert JF, Ford JA, Haeger SM, Yang Y, Dailey KL, Allison KC, Neudecker V, Evans CM, Richardson VL, Brodsky KS, Faubel S, Eltzschig HK, Schmidt EP, Ginde AA. A model-specific role of microRNA-223 as a mediator of kidney injury during experimental sepsis. Am J Physiol Renal Physiol. 2017 Aug 01; 313(2):F553-F559. PMID: 28515178.
    Citations: 15     Fields:    Translation:AnimalsCells
  43. Zhang X, Xu Y, Hsieh PH, Liu J, Lin L, Schmidt EP, Linhardt RJ. Chemoenzymatic synthesis of unmodified heparin oligosaccharides: cleavage of p-nitrophenyl glucuronide by alkaline and Smith degradation. Org Biomol Chem. 2017 Feb 01; 15(5):1222-1227. PMID: 28091666.
    Citations: 6     Fields:    Translation:Cells
  44. Colbert JF, Schmidt EP, Faubel S, Ginde AA. Severe Sepsis Outcomes Among Hospitalizations With Inflammatory Bowel Disease. Shock. 2017 02; 47(2):128-131. PMID: 27617672.
    Citations: 11     Fields:    Translation:Humans
  45. Schmidt EP, Overdier KH, Sun X, Lin L, Liu X, Yang Y, Ammons LA, Hiller TD, Suflita MA, Yu Y, Chen Y, Zhang F, Cothren Burlew C, Edelstein CL, Douglas IS, Linhardt RJ. Urinary Glycosaminoglycans Predict Outcomes in Septic Shock and Acute Respiratory Distress Syndrome. Am J Respir Crit Care Med. 2016 08 15; 194(4):439-49. PMID: 26926297; PMCID: PMC5003330.
    Citations: 57     Fields:    Translation:HumansCTClinical Trials
  46. Haeger SM, Yang Y, Schmidt EP. Heparan Sulfate in the Developing, Healthy, and Injured Lung. Am J Respir Cell Mol Biol. 2016 07; 55(1):5-11. PMID: 26982577.
    Citations: 33     Fields:    Translation:HumansAnimalsCells
  47. Schmidt EP, Kuebler WM, Lee WL, Downey GP. Adhesion Molecules: Master Controllers of the Circulatory System. Compr Physiol. 2016 Mar 15; 6(2):945-73. PMID: 27065171.
    Citations: 18     Fields:    Translation:HumansAnimals
  48. Colbert JF, Schmidt EP. Endothelial and Microcirculatory Function and Dysfunction in Sepsis. Clin Chest Med. 2016 06; 37(2):263-75. PMID: 27229643; PMCID: PMC4884305.
    Citations: 38     Fields:    Translation:HumansAnimals
  49. Morris A, Wang B, Waern I, Venkatasamy R, Page C, Schmidt EP, Wernersson S, Li JP, Spina D. The role of heparanase in pulmonary cell recruitment in response to an allergic but not non-allergic stimulus. PLoS One. 2015; 10(6):e0127032. PMID: 26039697.
    Citations: 17     Fields:    Translation:HumansAnimalsPHPublic Health
  50. Sun X, Li L, Overdier KH, Ammons LA, Douglas IS, Burlew CC, Zhang F, Schmidt EP, Chi L, Linhardt RJ. Analysis of Total Human Urinary Glycosaminoglycan Disaccharides by Liquid Chromatography-Tandem Mass Spectrometry. Anal Chem. 2015 Jun 16; 87(12):6220-7. PMID: 26005898.
    Citations: 32     Fields:    Translation:Humans
  51. Riches DW, Burnham EL, Moss M, Downey GP, Schmidt EP. Introduction to the 57th annual Thomas L. Petty Aspen Lung Conference: Rebuilding the injured lung. Ann Am Thorac Soc. 2015 Mar; 12 Suppl 1:S1-2. PMID: 25830827.
    Citations:    Fields:    Translation:HumansAnimalsCells
  52. Nadon AM, Perez MJ, Hernandez-Saavedra D, Smith LP, Yang Y, Sanders LA, Gandjeva A, Chabon J, Koyanagi DE, Graham BB, Tuder RM, Schmidt EP. Rtp801 suppression of epithelial mTORC1 augments endotoxin-induced lung inflammation. Am J Pathol. 2014 Sep; 184(9):2382-9. PMID: 25016184.
    Citations: 14     Fields:    Translation:Animals
  53. Damarla M, Parniani AR, Johnston L, Maredia H, Serebreni L, Hamdan O, Sidhaye VK, Shimoda LA, Myers AC, Crow MT, Schmidt EP, Machamer CE, Gaestel M, Rane MJ, Kolb TM, Kim BS, Damico RL, Hassoun PM. Mitogen-activated protein kinase-activated protein kinase 2 mediates apoptosis during lung vascular permeability by regulating movement of cleaved caspase 3. Am J Respir Cell Mol Biol. 2014 May; 50(5):932-41. PMID: 24304496; PMCID: PMC4068950.
    Citations: 17     Fields:    Translation:HumansAnimalsCells
  54. Schmidt EP, Li G, Li L, Fu L, Yang Y, Overdier KH, Douglas IS, Linhardt RJ. The circulating glycosaminoglycan signature of respiratory failure in critically ill adults. J Biol Chem. 2014 Mar 21; 289(12):8194-202. PMID: 24509853; PMCID: PMC3961648.
    Citations: 63     Fields:    Translation:HumansCTClinical Trials
  55. Bhargava R, Altmann CJ, Andres-Hernando A, Webb RG, Okamura K, Yang Y, Falk S, Schmidt EP, Faubel S. Acute lung injury and acute kidney injury are established by four hours in experimental sepsis and are improved with pre, but not post, sepsis administration of TNF-a antibodies. PLoS One. 2013; 8(11):e79037. PMID: 24265742.
    Citations: 38     Fields:    Translation:Animals
  56. Lygizos MI, Yang Y, Altmann CJ, Okamura K, Hernando AA, Perez MJ, Smith LP, Koyanagi DE, Gandjeva A, Bhargava R, Tuder RM, Faubel S, Schmidt EP. Heparanase mediates renal dysfunction during early sepsis in mice. Physiol Rep. 2013 Nov; 1(6):e00153. PMID: 24400155.
    Citations: 39     Fields:    
  57. Dengler V, Downey GP, Tuder RM, Eltzschig HK, Schmidt EP. Neutrophil intercellular communication in acute lung injury. Emerging roles of microparticles and gap junctions. Am J Respir Cell Mol Biol. 2013 Jul; 49(1):1-5. PMID: 23815257.
    Citations: 24     Fields:    Translation:HumansCells
  58. Yang Y, Yang G, Schmidt EP. In vivo measurement of the mouse pulmonary endothelial surface layer. J Vis Exp. 2013 Feb 22; (72):e50322. PMID: 23462690.
    Citations: 6     Fields:    Translation:AnimalsCells
  59. Yang Y, Schmidt EP. The endothelial glycocalyx: an important regulator of the pulmonary vascular barrier. Tissue Barriers. 2013 Jan 01; 1(1). PMID: 24073386; PMCID: PMC3781215.
    Citations: 41     Fields:    
  60. Chow K, Fessel JP, Schmidt EP, Gaskill C, Alvarez D, Graham B, Harrison DG, Wagner DH, Nozik-Grayck E, West JD, Klemm DJ, Majka SM. Dysfunctional resident lung mesenchymal stem cells contribute to pulmonary microvascular remodeling. Pulm Circ. 2013 Jan; 3(1):31-49. PMID: 23662173.
    Citations: 38     
  61. Schmidt EP, Yang Y, Janssen WJ, Gandjeva A, Perez MJ, Barthel L, Zemans RL, Bowman JC, Koyanagi DE, Yunt ZX, Smith LP, Cheng SS, Overdier KH, Thompson KR, Geraci MW, Douglas IS, Pearse DB, Tuder RM. The pulmonary endothelial glycocalyx regulates neutrophil adhesion and lung injury during experimental sepsis. Nat Med. 2012 Aug; 18(8):1217-23. PMID: 22820644; PMCID: PMC3723751.
    Citations: 309     Fields:    Translation:HumansAnimalsCells
  62. Schmidt EP. The expanding appreciation of heparanase in human disease. Neurosci Lett. 2012 Mar 05; 511(1):1-3. PMID: 22300958.
    Citations: 1     Fields:    Translation:HumansAnimals
  63. Carpenter TC, Schroeder W, Stenmark KR, Schmidt EP. Eph-A2 promotes permeability and inflammatory responses to bleomycin-induced lung injury. Am J Respir Cell Mol Biol. 2012 Jan; 46(1):40-7. PMID: 21799118.
    Citations: 27     Fields:    Translation:HumansAnimalsCells
  64. Schmidt EP, Lee WL, Zemans RL, Yamashita C, Downey GP. On, around, and through: neutrophil-endothelial interactions in innate immunity. Physiology (Bethesda). 2011 Oct; 26(5):334-47. PMID: 22013192; PMCID: PMC3684246.
    Citations: 44     Fields:    Translation:HumansAnimalsCells
  65. Tuder RM, Hunt JM, Schmidt EP. Hyperoxia and apoptosis. Too much of a good thing? Am J Respir Crit Care Med. 2011 Apr 15; 183(8):964-5. PMID: 21498818.
    Citations: 5     Fields:    Translation:Animals
  66. Schmidt EP, Tuder RM. Role of Apoptosis in Amplifying Inflammatory Responses in Lung Diseases. J Cell Death. 2010; 3:41-53. PMID: 28469476.
    Citations: 3     
  67. Schmidt EP, Tuder RM. Role of Apoptosis in Amplifying Inflammatory Responses in Lung Diseases. J Cell Death. 2010 Jul 20; 2010(3):41-53. PMID: 22081757.
    Citations: 32     
  68. Schmidt EP, Damarla M, Rentsendorj O, Servinsky LE, Zhu B, Moldobaeva A, Gonzalez A, Hassoun PM, Pearse DB. Soluble guanylyl cyclase contributes to ventilator-induced lung injury in mice. Am J Physiol Lung Cell Mol Physiol. 2008 Dec; 295(6):L1056-65. PMID: 18849438.
    Citations: 24     Fields:    Translation:AnimalsCells
  69. Schmidt EP, Drachman DB, Wiener CM, Clawson L, Kimball R, Lechtzin N. Pulmonary predictors of survival in amyotrophic lateral sclerosis: use in clinical trial design. Muscle Nerve. 2006 Jan; 33(1):127-32. PMID: 16258948.
    Citations: 16     Fields:    Translation:Humans
  70. Hann CL, Schmidt EP. Images in clinical medicine. Toxic neutrophils in Streptococcus pneumoniae sepsis. N Engl J Med. 2004 Dec 16; 351(25):2636. PMID: 15602024.
    Citations:    Fields:    Translation:HumansCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.