Title Associate Professor of Medicine Institution Massachusetts General Hospital Address Massachusetts General Hospital
55 Fruit St
Boston MA 02114
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Biography
| Dartmouth College, Hanover, NH | BA | 06/1997 | Government |
| University of Pittsburgh, Pittsburgh, PA | MD | 06/2001 | Medicine |
| Johns Hopkins Hospital, Baltimore, MD | | 06/2004 | Internal Medicine Residency |
| Johns Hopkins Hospital, Baltimore, MD | | 06/2006 | Assistant Chief of Service |
| Johns Hopkins Hospital, Baltimore, MD | | 06/2009 | Pulmonary/Critical Care Fellowship |
2001
Mayer A. Green Award in Internal Medicine
2001
Medical Alumni Association Recognition Award
2013
American Physiological Society Giles F. Filley Memorial Award
2013
University of Colorado Outstanding Early Career Scholar
2014
Denver Health Academic Excellence Award
2015
ATS Early Career Research Achievement Award
2019
Fellow of the American Thoracic Society
2023
American Society for Clinical Investigation
Overview
Our laboratory focuses on the mechanisms underlying sepsis and septic organ injury. We are particularly interested in the role of glycosaminoglycans (such as heparan sulfate) in the onset, propagation, and resolution of septic lung, kidney, and brain injury. Using novel glycoanalytical approaches, we seek to find new insights into the mechanistic and phenotypic heterogeneity of critical illness.
Research
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R21GM151565
(SCHMIDT, ERIC PETER)
Jul 14, 2023 - Aug 31, 2025
Optimization of a rapid assay to quantify circulating glycosaminoglycans and identify vascular endotypes of sepsis.
Role Description: The goal of this study is to test the accuracy of dimethylmethylene blue (DMMB) as a rapid, point-of-care assay of endothelial glycocalyx degradation, and then use this optimized assay to discern vascular endotypes of sepsis and septic shock.
Role: Principal Investigator
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R21GM151565
(SCHMIDT, ERIC PETER)
Jul 14, 2023 - Jun 30, 2025
Optimization of a rapid assay to quantify circulating glycosaminoglycans and identify vascular endotypes of sepsis
Role: Principal Investigator
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R01HL168892
(HERSON, PACO S)
Mar 15, 2023 - Feb 29, 2028
Vascular mechanisms of sepsis-induced cognitive dysfunction
Role: Co-Principal Investigator
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R01HL168892-01
(HERSON, PACO S)
Mar 15, 2023 - Feb 29, 2028
Vascular mechanisms of sepsis-induced cognitive dysfunction
Role Description: The goal of this study is to understand the mechanisms by which circulating heparan sulfates selectively penetrate memory centers of the brain, leading to cognitive impairment in sepsis survivors.
Role: Co-Principal Investigator
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R13HL152479
(SCHMIDT, ERIC PETER)
Jul 1, 2020 - Jun 30, 2021
ARDS in the 21st Century: New Insights into Clinical and Mechanistic Heterogeneity
Role: Principal Investigator
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R01HL149422
(SCHMIDT, ERIC PETER;SHAPIRO, NATHAN I)
Sep 1, 2019 - May 31, 2024
The Impact of Fluid Resuscitation on Glycocalyx Degradation in Septic Shock
Role: Co-Principal Investigator
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W81XWH1810682
(Schmidt, Eric Peter)
Sep 15, 2018 - Sep 14, 2022
Shedding of alveolar heparan sulfate mediates epithelial dysfunction in experimental and human ARDS
Role: Principal Investigator
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R01GM125095
(SCHMIDT, ERIC PETER)
Jul 15, 2017 - May 31, 2021
Targeting circulating endothelial glycocalyx fragments to reduce septic encephalopathy
Role: Principal Investigator
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W81XWH1610183
(Schmidt, Eric Peter)
Jul 1, 2016 - Dec 31, 2017
Reinforcing the endothelial surface layer to prevent lung injury
Role: Principal Investigator
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R01HL125371
(SCHMIDT, ERIC PETER)
Sep 15, 2014 - May 31, 2020
Endothelial glycocalyx reconstitution during sepsis
Role: Principal Investigator
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K08HL105538
(SCHMIDT, ERIC PETER)
Sep 1, 2011 - Jul 31, 2017
Pulmonary endothelial glycocalyx degradation causes ARDS during sepsis
Role: Principal Investigator
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P30HL101295
(GERACI, MARK W)
Sep 30, 2009 - Aug 31, 2011
Molecular Physiology Core Applied to Acute Lung Injury
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F32HL090296
(SCHMIDT, ERIC PETER)
Jul 1, 2007 - Jun 30, 2009
cGMP Compartmentalization in Pulmonary Endothelial Barrier Dysfunction
Role: Principal Investigator
Bibliographic
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