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Alicia Nicole Rizzo, M.D.,Ph.D.

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Biography
Johns Hopkins University , Baltimore, MDB.A.12/2009Cellular and Molecular Neuroscience
University of Illinois, Chicago, ILM.D., Ph.D.05/2017Medicine and Pharmacology
University of Colorado , Aurora, COResident06/2019Internal Medicine
University of Colorado, Aurora, COFellow06/2022Pulmonary and Critical Care Medicine
Harvard University , Boston, MAFellowPulmonary and Critical Care Medicine
2006 - 2010
Woodrow Wilson Undergraduate Research Fellowship
2014 - 2015
Chancellor's Graduate Research Fellowship
2014
Albert and Dorris Woeltien Poster Award, First Place
2015
Edward P. Cohen Alumni Award for Outstanding MSTP Student
2016
Hermann Rahn Award for Excellence in Pulmonary Research
2022 - 2023
ASCI Emerging Generation Award

Overview
I am a Pulmonary and Critical Care Medicine Fellow at Massachusetts General hospital working in the laboratory of Dr. Eric Schmidt. My main scientific interest is in the development and implementation of personalized medicine in the ICU. During my clinical training, I have observed significant heterogeneity in ARDS, and other critical illnesses; however, patient care in the ICU remains largely supportive. I plan to focus my career on identifying biomarkers that can be used to both identify mechanisms of injury and predict response to pharmacotherapies, so that targeted therapies can be applied to the patients who are most likely to derive benefit. My current research employs heat moisture exchange filters, devices that are routinely used to humidify the airways of mechanically ventilated patients, to noninvasively sample the airspace fluid of ARDS patients. My work identified a subgroup of ARDS patients who display damage to the alveolar epithelial glycocalyx, a layer of glycosaminoglycans that lines the airways. These patients display worse lung injury and require a longer duration of ventilator support than those without significant glycocalyx degradation. Through complementary mechanistic studies, I found that alveolar epithelial glycocalyx degradation induces lung injury by impairing surfactant function.

Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. L30HL159703 (RIZZO, ALICIA N) Nov 1, 2022
    NIH
    ARDS Endotyping via analysis of glycocalyx fragments in exhaled breath
    Role: Principal Investigator
  2. F32HL162230 (RIZZO, ALICIA N) Mar 1, 2022
    NIH
    Epithelial glycocalyx degradation mediates surfactant dysfunction in acute respiratory distress syndrome
    Role: Principal Investigator
  3. CO-M-21-5 (RIZZO, ALICIA N) May 1, 2021 - Jun 30, 2022
    University of Colorado Clinical and Translational Sciences Institute
    ARDS Endotyping via Analysis of Glycocalyx Fragments in Exhaled Breath
    Role: Principal Investigator
  4. F30HL121982 (RIZZO, ALICIA N) Sep 2, 2014 - Sep 1, 2019
    NIH
    Functional Characterization of ALI-Associated MYLK SNPs
    Role: Principal Investigator
  5. 14PRE18860021 (RIZZO, ALICIA N) Jan 1, 2014 - Dec 31, 2015
    AHA
    The Effects of Imatinib on Endothelial Dysfunction in Inflammatory Lung Disease
    Role: Principal Investigator

Bibliographic
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.