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Alicia Nicole Rizzo, M.D.,Ph.D.

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Johns Hopkins University , Baltimore, MDB.A.12/2009Cellular and Molecular Neuroscience
University of Illinois, Chicago, ILM.D., Ph.D.05/2017Medicine and Pharmacology
University of Colorado , Aurora, COResident06/2019Internal Medicine
University of Colorado, Aurora, COFellow06/2022Pulmonary and Critical Care Medicine
Harvard University , Boston, MAFellowPulmonary and Critical Care Medicine
2006 - 2010
Woodrow Wilson Undergraduate Research Fellowship
2014 - 2015
Chancellor's Graduate Research Fellowship
Albert and Dorris Woeltien Poster Award, First Place
Edward P. Cohen Alumni Award for Outstanding MSTP Student
Hermann Rahn Award for Excellence in Pulmonary Research
2022 - 2023
ASCI Emerging Generation Award

I am a Pulmonary and Critical Care Medicine Fellow at Massachusetts General hospital working in the laboratory of Dr. Eric Schmidt. My main scientific interest is in the development and implementation of personalized medicine in the ICU. During my clinical training, I have observed significant heterogeneity in ARDS, and other critical illnesses; however, patient care in the ICU remains largely supportive. I plan to focus my career on identifying biomarkers that can be used to both identify mechanisms of injury and predict response to pharmacotherapies, so that targeted therapies can be applied to the patients who are most likely to derive benefit. My current research employs heat moisture exchange filters, devices that are routinely used to humidify the airways of mechanically ventilated patients, to noninvasively sample the airspace fluid of ARDS patients. My work identified a subgroup of ARDS patients who display damage to the alveolar epithelial glycocalyx, a layer of glycosaminoglycans that lines the airways. These patients display worse lung injury and require a longer duration of ventilator support than those without significant glycocalyx degradation. Through complementary mechanistic studies, I found that alveolar epithelial glycocalyx degradation induces lung injury by impairing surfactant function.

The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. L30HL159703 (RIZZO, ALICIA N) Nov 1, 2022
    ARDS Endotyping via analysis of glycocalyx fragments in exhaled breath
    Role: Principal Investigator
  2. F32HL162230 (RIZZO, ALICIA N) Mar 1, 2022
    Epithelial glycocalyx degradation mediates surfactant dysfunction in acute respiratory distress syndrome
    Role: Principal Investigator
  3. CO-M-21-5 (RIZZO, ALICIA N) May 1, 2021 - Jun 30, 2022
    University of Colorado Clinical and Translational Sciences Institute
    ARDS Endotyping via Analysis of Glycocalyx Fragments in Exhaled Breath
    Role: Principal Investigator
  4. F30HL121982 (RIZZO, ALICIA N) Sep 2, 2014 - Sep 1, 2019
    Functional Characterization of ALI-Associated MYLK SNPs
    Role: Principal Investigator
  5. 14PRE18860021 (RIZZO, ALICIA N) Jan 1, 2014 - Dec 31, 2015
    The Effects of Imatinib on Endothelial Dysfunction in Inflammatory Lung Disease
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Rizzo AN, Schmidt EP. The role of the alveolar epithelial glycocalyx in acute respiratory distress syndrome. Am J Physiol Cell Physiol. 2023 Feb 27. PMID: 36847444.
    Citations:    Fields:    
  2. Rizzo AN, Aggarwal NR, Thompson BT, Schmidt EP. Advancing Precision Medicine for the Diagnosis and Treatment of Acute Respiratory Distress Syndrome. J Clin Med. 2023 Feb 16; 12(4). PMID: 36836098; PMCID: PMC9966442.
  3. Park BD, Kannappan A, Rizzo AN, Jin Y, Peterson RA, Burnham E, Moss M, Jolley S. Relationship Between a State-Directed Lockdown on Non-COVID-19-related ICU Admissions and Mortality in a Multicenter Colorado Healthcare System. Crit Care Explor. 2022 Dec; 4(12):e0791. PMID: 36506833; PMCID: PMC9726320.
  4. Rizzo AN, Yuan JX. NEDD9 provides mechanistic insight into the coagulopathy of COVID-19. Pulm Circ. 2022 Apr; 12(2):e12087. PMID: 35599982; PMCID: PMC9111000.
  5. Belvitch P, Casanova N, Sun X, Camp SM, Sammani S, Brown ME, Mascarhenas J, Lynn H, Adyshev D, Siegler J, Desai A, Seyed-Saadat L, Rizzo A, Bime C, Shekhawat GS, Dravid VP, Reilly JP, Jones TK, Feng R, Letsiou E, Meyer NJ, Ellis N, Garcia JGN, Dudek SM. A cortactin CTTN coding SNP contributes to lung vascular permeability and inflammatory disease severity in African descent subjects. Transl Res. 2022 06; 244:56-74. PMID: 35181549; PMCID: PMC9119916.
    Citations: 2     Fields:    Translation:HumansAnimals
  6. Rizzo AN, Haeger SM, Oshima K, Yang Y, Wallbank AM, Jin Y, Lettau M, McCaig LA, Wickersham NE, McNeil JB, Zakharevich I, McMurtry SA, Langouët-Astrié CJ, Kopf KW, Voelker DR, Hansen KC, Shaver CM, Kerchberger VE, Peterson RA, Kuebler WM, Ochs M, Veldhuizen RA, Smith BJ, Ware LB, Bastarache JA, Schmidt EP. Alveolar epithelial glycocalyx degradation mediates surfactant dysfunction and contributes to acute respiratory distress syndrome. JCI Insight. 2022 01 25; 7(2). PMID: 34874923; PMCID: PMC8855818.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  7. Rizzo AN, Schmidt EP. ABO blood type: a window into the genetics of acute respiratory distress syndrome susceptibility. J Clin Invest. 2021 01 04; 131(1). PMID: 33141764.
    Citations:    Fields:    Translation:HumansCells
  8. Rizzo AN, Belvitch P, Demeritte R, Garcia JGN, Letsiou E, Dudek SM. Arg mediates LPS-induced disruption of the pulmonary endothelial barrier. Vascul Pharmacol. 2020 May - Jun; 128-129:106677. PMID: 32240815.
    Citations: 7     Fields:    Translation:HumansCells
  9. Lynn H, Sun X, Ayshiev D, Siegler JH, Rizzo AN, Karnes JH, Gonzales Garay M, Wang T, Casanova N, Camp SM, Ellis NA, Garcia JGN. Single nucleotide polymorphisms in the MYLKP1 pseudogene are associated with increased colon cancer risk in African Americans. PLoS One. 2018; 13(8):e0200916. PMID: 30161129.
    Citations: 9     Fields:    Translation:HumansCells
  10. Rizzo AN, Dudek SM. Endothelial Glycocalyx Repair: Building a Wall to Protect the Lung during Sepsis. Am J Respir Cell Mol Biol. 2017 06; 56(6):687-688. PMID: 28569597; PMCID: PMC5516297.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  11. Belvitch P, Brown ME, Brinley BN, Letsiou E, Rizzo AN, Garcia JGN, Dudek SM. The ARP 2/3 complex mediates endothelial barrier function and recovery. Pulm Circ. 2017 Mar; 7(1):200-210. PMID: 28680579.
    Citations: 9     
  12. Belvitch P, Rizzo AN, Dudek SM. Cortactin in Atherosclerosis: Just Say NO. Arterioscler Thromb Vasc Biol. 2016 12; 36(12):2278-2280. PMID: 27879274.
    Citations: 1     Fields:    Translation:Humans
  13. Wang T, Mathew B, Wu X, Shimizu Y, Rizzo AN, Dudek SM, Weichselbaum RR, Jacobson JR, Hecker L, Garcia JG. Nonmuscle myosin light chain kinase activity modulates radiation-induced lung injury. Pulm Circ. 2016 Jun; 6(2):234-9. PMID: 27252850.
    Citations: 7     
  14. Yao Y, Zeng QX, Deng XQ, Tang GN, Guo JB, Sun YQ, Ru K, Rizzo AN, Shi JB, Fu QL. Connexin 43 Upregulation in Mouse Lungs during Ovalbumin-Induced Asthma. PLoS One. 2015; 10(12):e0144106. PMID: 26630490.
    Citations: 6     Fields:    Translation:AnimalsCells
  15. Peng H, Zhuang Y, Chen Y, Rizzo AN, Chen W. The Characteristics and Regulatory Mechanisms of Superoxide Generation from eNOS Reductase Domain. PLoS One. 2015; 10(10):e0140365. PMID: 26465144.
    Citations: 3     Fields:    Translation:AnimalsCells
  16. Rizzo AN, Sammani S, Esquinca AE, Jacobson JR, Garcia JG, Letsiou E, Dudek SM. Imatinib attenuates inflammation and vascular leak in a clinically relevant two-hit model of acute lung injury. Am J Physiol Lung Cell Mol Physiol. 2015 Dec 01; 309(11):L1294-304. PMID: 26432864.
    Citations: 43     Fields:    Translation:HumansAnimalsCells
  17. Rizzo AN, Aman J, van Nieuw Amerongen GP, Dudek SM. Targeting Abl kinases to regulate vascular leak during sepsis and acute respiratory distress syndrome. Arterioscler Thromb Vasc Biol. 2015 May; 35(5):1071-9. PMID: 25814671.
    Citations: 35     Fields:    Translation:HumansCells
  18. Chen W, Xiao H, Rizzo AN, Zhang W, Mai Y, Ye M. Endothelial nitric oxide synthase dimerization is regulated by heat shock protein 90 rather than by phosphorylation. PLoS One. 2014; 9(8):e105479. PMID: 25153129.
    Citations: 19     Fields:    Translation:AnimalsCells
  19. Frencher JT, Shen H, Yan L, Wilson JO, Freitag NE, Rizzo AN, Chen CY, Chen ZW. HMBPP-deficient Listeria mutant immunization alters pulmonary/systemic responses, effector functions, and memory polarization of V?2Vd2 T cells. J Leukoc Biol. 2014 Dec; 96(6):957-67. PMID: 25114162.
    Citations: 18     Fields:    Translation:AnimalsCellsPHPublic Health
  20. Belvitch P, Adyshev D, Elangovan VR, Brown ME, Naureckas C, Rizzo AN, Siegler JH, Garcia JG, Dudek SM. Proline-rich region of non-muscle myosin light chain kinase modulates kinase activity and endothelial cytoskeletal dynamics. Microvasc Res. 2014 Sep; 95:94-102. PMID: 25072537.
    Citations: 12     Fields:    Translation:HumansCells
  21. Goldman JL, Sammani S, Kempf C, Saadat L, Letsiou E, Wang T, Moreno-Vinasco L, Rizzo AN, Fortman JD, Garcia JG. Pleiotropic effects of interleukin-6 in a "two-hit" murine model of acute respiratory distress syndrome. Pulm Circ. 2014 Jun; 4(2):280-8. PMID: 25006447; PMCID: PMC4070787.
    Citations: 43     
  22. Chen W, Sharma R, Rizzo AN, Siegler JH, Garcia JG, Jacobson JR. Role of claudin-5 in the attenuation of murine acute lung injury by simvastatin. Am J Respir Cell Mol Biol. 2014 Feb; 50(2):328-36. PMID: 24028293.
    Citations: 28     Fields:    Translation:HumansAnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.