Harvard Catalyst Profiles

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Jed L. Hubbs, Ph.D.


Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Ralvenius WT, Neumann E, Pagani M, Acuña MA, Wildner H, Benke D, Fischer N, Rostaher A, Schwager S, Detmar M, Frauenknecht K, Aguzzi A, Hubbs JL, Rudolph U, Favrot C, Zeilhofer HU. Itch suppression in mice and dogs by modulation of spinal a2 and a3GABAA receptors. Nat Commun. 2018 08 13; 9(1):3230. PMID: 30104684; PMCID: PMC6089996.
    Citations: 15     Fields:    Translation:HumansAnimalsCells
  2. Hubbs JL, Fuller NO, Austin WF, Shen R, Ma J, Gong Z, Li J, McKee TD, Loureiro RM, Tate B, Dumin JA, Ives J, Bronk BS. Minimization of drug-drug interaction risk and candidate selection in a natural product-based class of gamma-secretase modulators. Bioorg Med Chem Lett. 2015 Apr 01; 25(7):1621-6. PMID: 25708617.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  3. Methot JL, Hoffman DM, Witter DJ, Stanton MG, Harrington P, Hamblett C, Siliphaivanh P, Wilson K, Hubbs J, Heidebrecht R, Kral AM, Ozerova N, Fleming JC, Wang H, Szewczak AA, Middleton RE, Hughes B, Cruz JC, Haines BB, Chenard M, Kenific CM, Harsch A, Secrist JP, Miller TA. Delayed and Prolonged Histone Hyperacetylation with a Selective HDAC1/HDAC2 Inhibitor. ACS Med Chem Lett. 2014 Apr 10; 5(4):340-5. PMID: 24900838.
    Citations: 6     
  4. Loureiro RM, Dumin JA, McKee TD, Austin WF, Fuller NO, Hubbs JL, Shen R, Jonker J, Ives J, Bronk BS, Tate B. Efficacy of SPI-1865, a novel gamma-secretase modulator, in multiple rodent models. Alzheimers Res Ther. 2013; 5(2):19. PMID: 23597079; PMCID: PMC3707052.
    Citations: 9     Fields:    
  5. Tate B, McKee TD, Loureiro RM, Dumin JA, Xia W, Pojasek K, Austin WF, Fuller NO, Hubbs JL, Shen R, Jonker J, Ives J, Bronk BS. Modulation of gamma-secretase for the treatment of Alzheimer's disease. Int J Alzheimers Dis. 2012; 2012:210756. PMID: 23320246; PMCID: PMC3536039.
    Citations: 11     
  6. Hubbs JL, Fuller NO, Austin WF, Shen R, Creaser SP, McKee TD, Loureiro RM, Tate B, Xia W, Ives J, Bronk BS. Optimization of a natural product-based class of ?-secretase modulators. J Med Chem. 2012 Nov 08; 55(21):9270-82. PMID: 23030762.
    Citations: 13     Fields:    Translation:HumansAnimalsCells
  7. Fuller NO, Hubbs JL, Austin WF, Creaser SP, McKee TD, Loureiro RM, Tate B, Xia W, Ives JL, Findeis MA, Bronk BS. Initial Optimization of a New Series of ?-Secretase Modulators Derived from a Triterpene Glycoside. ACS Med Chem Lett. 2012 Nov 08; 3(11):908-13. PMID: 24900406; PMCID: PMC4025870.
    Citations: 3     
  8. Rivkin A, Ahearn SP, Chichetti SM, Hamblett CL, Garcia Y, Martinez M, Hubbs JL, Reutershan MH, Daniels MH, Siliphaivanh P, Otte KM, Li C, Rosenau A, Surdi LM, Jung J, Hughes BL, Crispino JL, Nikov GN, Middleton RE, Moxham CM, Szewczak AA, Shah S, Moy LY, Kenific CM, Tanga F, Cruz JC, Andrade P, Angagaw MH, Shomer NH, Miller T, Munoz B, Shearman MS. Purine derivatives as potent gamma-secretase modulators. Bioorg Med Chem Lett. 2010 Apr 01; 20(7):2279-82. PMID: 20207146.
    Citations: 9     Fields:    Translation:HumansAnimals
  9. Stanton MG, Hubbs J, Sloman D, Hamblett C, Andrade P, Angagaw M, Bi G, Black RM, Crispino J, Cruz JC, Fan E, Farris G, Hughes BL, Kenific CM, Middleton RE, Nikov G, Sajonz P, Shah S, Shomer N, Szewczak AA, Tanga F, Tudge MT, Shearman M, Munoz B. Fluorinated piperidine acetic acids as gamma-secretase modulators. Bioorg Med Chem Lett. 2010 Jan 15; 20(2):755-8. PMID: 20005099.
    Citations: 7     Fields:    Translation:Animals
  10. Hubbs JL, Zhou H, Kral AM, Fleming JC, Dahlberg WK, Hughes BL, Middleton RE, Szewczak AA, Secrist JP, Miller TA. Amino acid derivatives as histone deacetylase inhibitors. Bioorg Med Chem Lett. 2008 Jan 01; 18(1):34-8. PMID: 18042381.
    Citations: 3     Fields:    Translation:HumansCells
  11. Hubbs JL, Heathcock CH. A second-generation synthesis of the C1-C28 portion of the altohyrtins (spongistatins). J Am Chem Soc. 2003 Oct 22; 125(42):12836-43. PMID: 14558832.
    Citations: 13     Fields:    Translation:Cells
  12. Heathcock CH, McLaughlin M, Medina J, Hubbs JL, Wallace GA, Scott R, Claffey MM, Hayes CJ, Ott GR. Multigram synthesis of the C29-C51 subunit and completion of the total synthesis of altohyrtin C (spongistatin 2). J Am Chem Soc. 2003 Oct 22; 125(42):12844-9. PMID: 14558833.
    Citations: 18     Fields:    
  13. Evans DA, Downey CW, Hubbs JL. Ni(II) bis(oxazoline)-catalyzed enantioselective syn aldol reactions of N-propionylthiazolidinethiones in the presence of silyl triflates. J Am Chem Soc. 2003 Jul 23; 125(29):8706-7. PMID: 12862448.
    Citations: 17     Fields:    
  14. Hubbs JL, Heathcock CH. Total synthesis of (+/-)-isoschizogamine. Org Lett. 1999 Oct 21; 1(8):1315-7. PMID: 10825981.
    Citations: 5     Fields:    
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.