Harvard Catalyst Profiles

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Reisa Anne Sperling, M.D.

Co-Author

This page shows the publications co-authored by Reisa Sperling and Aaron Schultz.
Connection Strength

9.723
  1. Phases of Hyperconnectivity and Hypoconnectivity in the Default Mode and Salience Networks Track with Amyloid and Tau in Clinically Normal Individuals. J Neurosci. 2017 04 19; 37(16):4323-4331.
    View in: PubMed
    Score: 0.681
  2. Template based rotation: a method for functional connectivity analysis with a priori templates. Neuroimage. 2014 Nov 15; 102 Pt 2:620-36.
    View in: PubMed
    Score: 0.570
  3. Association of Emerging ß-Amyloid and Tau Pathology With Early Cognitive Changes in Clinically Normal Older Adults. Neurology. 2022 04 12; 98(15):e1512-e1524.
    View in: PubMed
    Score: 0.241
  4. Resting-state functional connectivity and amyloid burden influence longitudinal cortical thinning in the default mode network in preclinical Alzheimer's disease. Neuroimage Clin. 2020; 28:102407.
    View in: PubMed
    Score: 0.216
  5. Sex Mediates Relationships Between Regional Tau Pathology and Cognitive Decline. Ann Neurol. 2020 11; 88(5):921-932.
    View in: PubMed
    Score: 0.216
  6. Inferior temporal tau is associated with accelerated prospective cortical thinning in clinically normal older adults. Neuroimage. 2020 10 15; 220:116991.
    View in: PubMed
    Score: 0.213
  7. Longitudinal degradation of the default/salience network axis in symptomatic individuals with elevated amyloid burden. Neuroimage Clin. 2020; 26:102052.
    View in: PubMed
    Score: 0.204
  8. Amyloid imaging of dutch-type hereditary cerebral amyloid angiopathy carriers. Ann Neurol. 2019 10; 86(4):616-625.
    View in: PubMed
    Score: 0.201
  9. Anticholinergic Amnesia is Mediated by Alterations in Human Network Connectivity Architecture. Cereb Cortex. 2019 07 22; 29(8):3445-3456.
    View in: PubMed
    Score: 0.200
  10. Sex Differences in the Association of Global Amyloid and Regional Tau Deposition Measured by Positron Emission Tomography in Clinically Normal Older Adults. JAMA Neurol. 2019 05 01; 76(5):542-551.
    View in: PubMed
    Score: 0.197
  11. The impact of amyloid-beta and tau on prospective cognitive decline in older individuals. Ann Neurol. 2019 02; 85(2):181-193.
    View in: PubMed
    Score: 0.194
  12. An UNC5C Allele Predicts Cognitive Decline and Hippocampal Atrophy in Clinically Normal Older Adults. J Alzheimers Dis. 2019; 68(3):1161-1170.
    View in: PubMed
    Score: 0.193
  13. Tau Accumulation in Clinically Normal Older Adults Is Associated with Hippocampal Hyperactivity. J Neurosci. 2019 01 16; 39(3):548-556.
    View in: PubMed
    Score: 0.192
  14. Nonlinear Distributional Mapping (NoDiM) for harmonization across amyloid-PET radiotracers. Neuroimage. 2019 02 01; 186:446-454.
    View in: PubMed
    Score: 0.191
  15. Age-Related Increases in Tip-of-the-tongue are Distinct from Decreases in Remembering Names: A Functional MRI Study. Cereb Cortex. 2017 09 01; 27(9):4339-4349.
    View in: PubMed
    Score: 0.176
  16. The association between tau PET and retrospective cortical thinning in clinically normal elderly. Neuroimage. 2017 08 15; 157:612-622.
    View in: PubMed
    Score: 0.172
  17. Cued memory decline in biomarker-defined preclinical Alzheimer disease. Neurology. 2017 Apr 11; 88(15):1431-1438.
    View in: PubMed
    Score: 0.170
  18. Early and late change on the preclinical Alzheimer's cognitive composite in clinically normal older individuals with elevated amyloid ß. Alzheimers Dement. 2017 Sep; 13(9):1004-1012.
    View in: PubMed
    Score: 0.170
  19. Heterogeneity in Suspected Non-Alzheimer Disease Pathophysiology Among Clinically Normal Older Individuals. JAMA Neurol. 2016 Oct 01; 73(10):1185-1191.
    View in: PubMed
    Score: 0.165
  20. Tau positron emission tomographic imaging in aging and early Alzheimer disease. Ann Neurol. 2016 Jan; 79(1):110-9.
    View in: PubMed
    Score: 0.156
  21. Harvard Aging Brain Study: Dataset and accessibility. Neuroimage. 2017 01; 144(Pt B):255-258.
    View in: PubMed
    Score: 0.149
  22. Amyloid-ß deposition in mild cognitive impairment is associated with increased hippocampal activity, atrophy and clinical progression. Brain. 2015 Apr; 138(Pt 4):1023-35.
    View in: PubMed
    Score: 0.147
  23. Synergistic effect of ß-amyloid and neurodegeneration on cognitive decline in clinically normal individuals. JAMA Neurol. 2014 Nov; 71(11):1379-85.
    View in: PubMed
    Score: 0.144
  24. Relationships between default-mode network connectivity, medial temporal lobe structure, and age-related memory deficits. Neurobiol Aging. 2015 Jan; 36(1):265-72.
    View in: PubMed
    Score: 0.141
  25. Amyloid deposition is linked to aberrant entorhinal activity among cognitively normal older adults. J Neurosci. 2014 Apr 09; 34(15):5200-10.
    View in: PubMed
    Score: 0.139
  26. Daytime sleepiness is associated with decreased default mode network connectivity in both young and cognitively intact elderly subjects. Sleep. 2013 Nov 01; 36(11):1609-15.
    View in: PubMed
    Score: 0.135
  27. Impaired default network functional connectivity in autosomal dominant Alzheimer disease. Neurology. 2013 Aug 20; 81(8):736-44.
    View in: PubMed
    Score: 0.132
  28. The parahippocampal gyrus links the default-mode cortical network with the medial temporal lobe memory system. Hum Brain Mapp. 2014 Mar; 35(3):1061-73.
    View in: PubMed
    Score: 0.128
  29. The encoding/retrieval flip: interactions between memory performance and memory stage and relationship to intrinsic cortical networks. J Cogn Neurosci. 2013 Jul; 25(7):1163-79.
    View in: PubMed
    Score: 0.128
  30. Neuronal dysfunction and disconnection of cortical hubs in non-demented subjects with elevated amyloid burden. Brain. 2011 Jun; 134(Pt 6):1635-46.
    View in: PubMed
    Score: 0.113
  31. Tau mediates synergistic influence of vascular risk and Aß on cognitive decline. Ann Neurol. 2022 Jul 26.
    View in: PubMed
    Score: 0.062
  32. Harmonizing the preclinical Alzheimer cognitive composite for multicohort studies. Neuropsychology. 2022 Jul 21.
    View in: PubMed
    Score: 0.062
  33. Physical activity is associated with increased resting-state functional connectivity in networks predictive of cognitive decline in clinically unimpaired older adults. Alzheimers Dement (Amst). 2022; 14(1):e12319.
    View in: PubMed
    Score: 0.061
  34. Progressive White Matter Injury in Preclinical Dutch Cerebral Amyloid Angiopathy. Ann Neurol. 2022 09; 92(3):358-363.
    View in: PubMed
    Score: 0.061
  35. Divergent Cortical Tau Positron Emission Tomography Patterns Among Patients With Preclinical Alzheimer Disease. JAMA Neurol. 2022 06 01; 79(6):592-603.
    View in: PubMed
    Score: 0.061
  36. Association of ß-Amyloid and Vascular Risk on Longitudinal Patterns of Brain Atrophy. Neurology. 2022 Apr 26.
    View in: PubMed
    Score: 0.061
  37. Brain charts for the human lifespan. Nature. 2022 04; 604(7906):525-533.
    View in: PubMed
    Score: 0.060
  38. Lower novelty-related locus coeruleus function is associated with Aß-related cognitive decline in clinically healthy individuals. Nat Commun. 2022 03 23; 13(1):1571.
    View in: PubMed
    Score: 0.060
  39. Variant-dependent heterogeneity in amyloid ß burden in autosomal dominant Alzheimer's disease: cross-sectional and longitudinal analyses of an observational study. Lancet Neurol. 2022 02; 21(2):140-152.
    View in: PubMed
    Score: 0.060
  40. Neuroimaging correlates of Stages of Objective Memory Impairment (SOMI) system. Alzheimers Dement (Amst). 2021; 13(1):e12224.
    View in: PubMed
    Score: 0.059
  41. Unsupervised mobile cognitive testing for use in preclinical Alzheimer's disease. Alzheimers Dement (Amst). 2021; 13(1):e12243.
    View in: PubMed
    Score: 0.058
  42. Association of cortical microstructure with amyloid-ß and tau: impact on cognitive decline, neurodegeneration, and clinical progression in older adults. Mol Psychiatry. 2021 12; 26(12):7813-7822.
    View in: PubMed
    Score: 0.058
  43. Plasma IL-12/IFN-? axis predicts cognitive trajectories in cognitively unimpaired older adults. Alzheimers Dement. 2022 04; 18(4):645-653.
    View in: PubMed
    Score: 0.057
  44. Comparing PET and MRI Biomarkers Predicting Cognitive Decline in Preclinical Alzheimer Disease. Neurology. 2021 May 05.
    View in: PubMed
    Score: 0.057
  45. Changing the face of neuroimaging research: Comparing a new MRI de-facing technique with popular alternatives. Neuroimage. 2021 05 01; 231:117845.
    View in: PubMed
    Score: 0.056
  46. The cortical origin and initial spread of medial temporal tauopathy in Alzheimer's disease assessed with positron emission tomography. Sci Transl Med. 2021 01 20; 13(577).
    View in: PubMed
    Score: 0.056
  47. Longitudinal amyloid and tau accumulation in autosomal dominant Alzheimer's disease: findings from the Colombia-Boston (COLBOS) biomarker study. Alzheimers Res Ther. 2021 01 15; 13(1):27.
    View in: PubMed
    Score: 0.056
  48. Diminished Learning Over Repeated Exposures (LORE) in preclinical Alzheimer's disease. Alzheimers Dement (Amst). 2020; 12(1):e12132.
    View in: PubMed
    Score: 0.055
  49. Plasma N-terminal tau fragment levels predict future cognitive decline and neurodegeneration in healthy elderly individuals. Nat Commun. 2020 11 27; 11(1):6024.
    View in: PubMed
    Score: 0.055
  50. Defining the Lowest Threshold for Amyloid-PET to Predict Future Cognitive Decline and Amyloid Accumulation. Neurology. 2021 01 26; 96(4):e619-e631.
    View in: PubMed
    Score: 0.055
  51. Decline in cognitively complex everyday activities accelerates along the Alzheimer's disease continuum. Alzheimers Res Ther. 2020 10 29; 12(1):138.
    View in: PubMed
    Score: 0.055
  52. The neurophysiology and seizure outcomes of late onset unexplained epilepsy. Clin Neurophysiol. 2020 11; 131(11):2667-2672.
    View in: PubMed
    Score: 0.054
  53. Multiple markers contribute to risk of progression from normal to mild cognitive impairment. Neuroimage Clin. 2020; 28:102400.
    View in: PubMed
    Score: 0.054
  54. Visual short-term memory relates to tau and amyloid burdens in preclinical autosomal dominant Alzheimer's disease. Alzheimers Res Ther. 2020 08 21; 12(1):99.
    View in: PubMed
    Score: 0.054
  55. Associative memory and in vivo brain pathology in asymptomatic presenilin-1 E280A carriers. Neurology. 2020 09 08; 95(10):e1312-e1321.
    View in: PubMed
    Score: 0.053
  56. The presubiculum links incipient amyloid and tau pathology to memory function in older persons. Neurology. 2020 05 05; 94(18):e1916-e1928.
    View in: PubMed
    Score: 0.053
  57. Functional and Pathological Correlates of Judgments of Learning in Cognitively Unimpaired Older Adults. Cereb Cortex. 2020 03 14; 30(3):1974-1983.
    View in: PubMed
    Score: 0.052
  58. Amyloid-beta burden predicts prospective decline in body mass index in clinically normal adults. Neurobiol Aging. 2020 09; 93:124-130.
    View in: PubMed
    Score: 0.052
  59. Association of subjective cognitive decline with markers of brain pathology in preclinical autosomal dominant Alzheimer's disease. J Neurol Neurosurg Psychiatry. 2020 03; 91(3):330-332.
    View in: PubMed
    Score: 0.052
  60. Resistance to autosomal dominant Alzheimer's disease in an APOE3 Christchurch homozygote: a case report. Nat Med. 2019 11; 25(11):1680-1683.
    View in: PubMed
    Score: 0.051
  61. Associations of Physical Activity and ß-Amyloid With Longitudinal Cognition and Neurodegeneration in Clinically Normal Older Adults. JAMA Neurol. 2019 Oct 01; 76(10):1203-1210.
    View in: PubMed
    Score: 0.051
  62. Using subjective cognitive decline to identify high global amyloid in community-based samples: A cross-cohort study. Alzheimers Dement (Amst). 2019 Dec; 11:670-678.
    View in: PubMed
    Score: 0.051
  63. Association of Amyloid and Tau With Cognition in Preclinical Alzheimer Disease: A Longitudinal Study. JAMA Neurol. 2019 Aug 01; 76(8):915-924.
    View in: PubMed
    Score: 0.050
  64. Associations between baseline amyloid, sex, and APOE on subsequent tau accumulation in cerebrospinal fluid. Neurobiol Aging. 2019 06; 78:178-185.
    View in: PubMed
    Score: 0.049
  65. Striatal amyloid is associated with tauopathy and memory decline in familial Alzheimer's disease. Alzheimers Res Ther. 2019 02 04; 11(1):17.
    View in: PubMed
    Score: 0.049
  66. Vascular Risk and ß-Amyloid Are Synergistically Associated with Cortical Tau. Ann Neurol. 2019 02; 85(2):272-279.
    View in: PubMed
    Score: 0.048
  67. Regional Tau Correlates of Instrumental Activities of Daily Living and Apathy in Mild Cognitive Impairment and Alzheimer's Disease Dementia. J Alzheimers Dis. 2019; 67(2):757-768.
    View in: PubMed
    Score: 0.048
  68. Regional tau pathology and loneliness in cognitively normal older adults. Transl Psychiatry. 2018 12 18; 8(1):282.
    View in: PubMed
    Score: 0.048
  69. Learnings about the complexity of extracellular tau aid development of a blood-based screen for Alzheimer's disease. Alzheimers Dement. 2019 03; 15(3):487-496.
    View in: PubMed
    Score: 0.048
  70. Interactive Associations of Vascular Risk and ß-Amyloid Burden With Cognitive Decline in Clinically Normal Elderly Individuals: Findings From the Harvard Aging Brain Study. JAMA Neurol. 2018 09 01; 75(9):1124-1131.
    View in: PubMed
    Score: 0.047
  71. Sex, amyloid, and APOE e4 and risk of cognitive decline in preclinical Alzheimer's disease: Findings from three well-characterized cohorts. Alzheimers Dement. 2018 09; 14(9):1193-1203.
    View in: PubMed
    Score: 0.046
  72. PET staging of amyloidosis using striatum. Alzheimers Dement. 2018 10; 14(10):1281-1292.
    View in: PubMed
    Score: 0.046
  73. Association Between Amyloid and Tau Accumulation in Young Adults With Autosomal Dominant Alzheimer Disease. JAMA Neurol. 2018 05 01; 75(5):548-556.
    View in: PubMed
    Score: 0.046
  74. Preferential degradation of cognitive networks differentiates Alzheimer's disease from ageing. Brain. 2018 05 01; 141(5):1486-1500.
    View in: PubMed
    Score: 0.046
  75. Structural tract alterations predict downstream tau accumulation in amyloid-positive older individuals. Nat Neurosci. 2018 03; 21(3):424-431.
    View in: PubMed
    Score: 0.045
  76. 18F-Flortaucipir Binding in Choroid Plexus: Related to Race and Hippocampus Signal. J Alzheimers Dis. 2018; 62(4):1691-1702.
    View in: PubMed
    Score: 0.045
  77. Region-Specific Association of Subjective Cognitive Decline With Tauopathy Independent of Global ß-Amyloid Burden. JAMA Neurol. 2017 12 01; 74(12):1455-1463.
    View in: PubMed
    Score: 0.045
  78. Interactive versus additive relationships between regional cortical thinning and amyloid burden in predicting clinical decline in mild AD and MCI individuals. Neuroimage Clin. 2018; 17:388-396.
    View in: PubMed
    Score: 0.044
  79. Hierarchical Organization of Tau and Amyloid Deposits in the Cerebral Cortex. JAMA Neurol. 2017 07 01; 74(7):813-820.
    View in: PubMed
    Score: 0.043
  80. Functional network integrity presages cognitive decline in preclinical Alzheimer disease. Neurology. 2017 Jul 04; 89(1):29-37.
    View in: PubMed
    Score: 0.043
  81. Neuroimaging markers associated with maintenance of optimal memory performance in late-life. Neuropsychologia. 2017 06; 100:164-170.
    View in: PubMed
    Score: 0.043
  82. Fluorodeoxyglucose metabolism associated with tau-amyloid interaction predicts memory decline. Ann Neurol. 2017 Apr; 81(4):583-596.
    View in: PubMed
    Score: 0.043
  83. Depressive Symptoms and Tau Accumulation in the Inferior Temporal Lobe and Entorhinal Cortex in Cognitively Normal Older Adults: A Pilot Study. J Alzheimers Dis. 2017; 59(3):975-985.
    View in: PubMed
    Score: 0.042
  84. Alzheimer's Disease Biomarkers and Future Decline in Cognitive Normal Older Adults. J Alzheimers Dis. 2017; 60(4):1451-1459.
    View in: PubMed
    Score: 0.042
  85. Epicenters of dynamic connectivity in the adaptation of the ventral visual system. Hum Brain Mapp. 2017 04; 38(4):1965-1976.
    View in: PubMed
    Score: 0.042
  86. Tau Positron Emission Tomographic Imaging in the Lewy Body Diseases. JAMA Neurol. 2016 Nov 01; 73(11):1334-1341.
    View in: PubMed
    Score: 0.041
  87. Temporal T807 binding correlates with CSF tau and phospho-tau in normal elderly. Neurology. 2016 Aug 30; 87(9):920-6.
    View in: PubMed
    Score: 0.041
  88. In Vivo Tau, Amyloid, and Gray Matter Profiles in the Aging Brain. J Neurosci. 2016 07 13; 36(28):7364-74.
    View in: PubMed
    Score: 0.041
  89. Decreased hippocampal metabolism in high-amyloid mild cognitive impairment. Alzheimers Dement. 2016 12; 12(12):1288-1296.
    View in: PubMed
    Score: 0.041
  90. Lower Late-Life Body-Mass Index is Associated with Higher Cortical Amyloid Burden in Clinically Normal Elderly. J Alzheimers Dis. 2016 06 18; 53(3):1097-105.
    View in: PubMed
    Score: 0.040
  91. Cortical atrophy in patients with cerebral amyloid angiopathy: a case-control study. Lancet Neurol. 2016 07; 15(8):811-819.
    View in: PubMed
    Score: 0.040
  92. Different partial volume correction methods lead to different conclusions: An (18)F-FDG-PET study of aging. Neuroimage. 2016 05 15; 132:334-343.
    View in: PubMed
    Score: 0.040
  93. Blood-Borne Activity-Dependent Neuroprotective Protein (ADNP) is Correlated with Premorbid Intelligence, Clinical Stage, and Alzheimer's Disease Biomarkers. J Alzheimers Dis. 2016; 50(1):249-60.
    View in: PubMed
    Score: 0.039
  94. Biomarker validation of a decline in semantic processing in preclinical Alzheimer's disease. Neuropsychology. 2016 07; 30(5):624-30.
    View in: PubMed
    Score: 0.039
  95. Brain Imaging and Blood Biomarker Abnormalities in Children With Autosomal Dominant Alzheimer Disease: A Cross-Sectional Study. JAMA Neurol. 2015 Aug; 72(8):912-9.
    View in: PubMed
    Score: 0.038
  96. Functional Connectivity in Multiple Cortical Networks Is Associated with Performance Across Cognitive Domains in Older Adults. Brain Connect. 2015 Oct; 5(8):505-16.
    View in: PubMed
    Score: 0.038
  97. Cognitive activity relates to cognitive performance but not to Alzheimer disease biomarkers. Neurology. 2015 Jul 07; 85(1):48-55.
    View in: PubMed
    Score: 0.038
  98. Decoupling of structural and functional brain connectivity in older adults with white matter hyperintensities. Neuroimage. 2015 Aug 15; 117:222-9.
    View in: PubMed
    Score: 0.038
  99. Odor identification and Alzheimer disease biomarkers in clinically normal elderly. Neurology. 2015 May 26; 84(21):2153-60.
    View in: PubMed
    Score: 0.037
  100. Depressive Symptoms and Biomarkers of Alzheimer's Disease in Cognitively Normal Older Adults. J Alzheimers Dis. 2015; 46(1):63-73.
    View in: PubMed
    Score: 0.037
  101. Neuropsychiatric Symptoms and Functional Connectivity in Mild Cognitive Impairment. J Alzheimers Dis. 2015; 46(3):727-35.
    View in: PubMed
    Score: 0.037
  102. Apathy is associated with lower inferior temporal cortical thickness in mild cognitive impairment and normal elderly individuals. J Neuropsychiatry Clin Neurosci. 2015; 27(1):e22-7.
    View in: PubMed
    Score: 0.036
  103. Multiple Brain Markers are Linked to Age-Related Variation in Cognition. Cereb Cortex. 2016 Apr; 26(4):1388-400.
    View in: PubMed
    Score: 0.036
  104. Functional connectivity in autosomal dominant and late-onset Alzheimer disease. JAMA Neurol. 2014 Sep; 71(9):1111-22.
    View in: PubMed
    Score: 0.036
  105. Amyloid and APOE e4 interact to influence short-term decline in preclinical Alzheimer disease. Neurology. 2014 May 20; 82(20):1760-7.
    View in: PubMed
    Score: 0.035
  106. Cognitive profile of amyloid burden and white matter hyperintensities in cognitively normal older adults. J Neurosci. 2012 Nov 14; 32(46):16233-42.
    View in: PubMed
    Score: 0.032
Connection Strength
The connection strength for co-authors is the sum of the scores for each of their shared publications.

Publication scores are based on many factors, including how long ago they were written and whether the person is a first or senior author.
Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.