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Reisa Anne Sperling, M.D.

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Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. U24AG057437 (AISEN, PAUL S.) Dec 2, 2017 - Feb 28, 2018
    NIH/NIA
    Alzheimer's Clinical Trials Consortium (ACTC)
    Role: Co-Principal Investigator
  2. R01AG053798 (AISEN, PAUL S.) May 1, 2017 - Apr 30, 2022
    NIH/NIA
    Global Alzheimer's Platform Trial-Ready Cohort for Preclinical/Prodromal Alzheimer's Disease
    Role: Co-Principal Investigator
  3. R01AG054029 (SPERLING, REISA A.) Aug 15, 2016 - Apr 30, 2021
    NIH/NIA
    The A3 Study: Ante-Amyloid Prevention of Alzheimer's disease
    Role: Co-Principal Investigator
  4. P01AG036694 (SPERLING, REISA A.) Jul 15, 2010 - Mar 31, 2020
    NIH/NIA
    Impact of Amyloid and Tau on the Aging Brain: The Harvard Aging Brain Study
    Role: Co-Principal Investigator
  5. K24AG035007 (SPERLING, REISA A.) Dec 1, 2009 - Mar 31, 2021
    NIH/NIA
    Mentoring Imaging Research in Early AD
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Müller S, Preische O, Sohrabi HR, Gräber S, Jucker M, Ringman JM, Martins RN, McDade E, Schofield PR, Ghetti B, Rossor M, Fox NN, Graff-Radford NR, Levin J, Danek A, Vöglein J, Salloway S, Xiong C, Benzinger T, Buckles V, Masters CL, Sperling R, Bateman RJ, Morris JC, Laske C. Relationship between physical activity, cognition, and Alzheimer pathology in autosomal dominant Alzheimer's disease. Alzheimers Dement. 2018 Sep 21. PMID: 30266303.
    View in: PubMed
  2. Rieckmann A, Johnson KA, Sperling RA, Buckner RL, Hedden T. Dedifferentiation of caudate functional connectivity and striatal dopamine transporter density predict memory change in normal aging. Proc Natl Acad Sci U S A. 2018 10 02; 115(40):10160-10165. PMID: 30224467.
    View in: PubMed
  3. McDade E, Wang G, Gordon BA, Hassenstab J, Benzinger TLS, Buckles V, Fagan AM, Holtzman DM, Cairns NJ, Goate AM, Marcus DS, Morris JC, Paumier K, Xiong C, Allegri R, Berman SB, Klunk W, Noble J, Ringman J, Ghetti B, Farlow M, Sperling RA, Chhatwal J, Salloway S, Graff-Radford NR, Schofield PR, Masters C, Rossor MN, Fox NC, Levin J, Jucker M, Bateman RJ. Longitudinal cognitive and biomarker changes in dominantly inherited Alzheimer disease. Neurology. 2018 Oct 02; 91(14):e1295-e1306. PMID: 30217935.
    View in: PubMed
  4. Chhatwal JP, Schultz AP, Hedden T, Boot BP, Wigman S, Rentz D, Johnson KA, Sperling RA. Anticholinergic Amnesia is Mediated by Alterations in Human Network Connectivity Architecture. Cereb Cortex. 2018 Sep 06. PMID: 30192928.
    View in: PubMed
  5. Amariglio RE, Buckley RF, Mormino EC, Marshall GA, Johnson KA, Rentz DM, Sperling RA. Amyloid-associated increases in longitudinal report of subjective cognitive complaints. Alzheimers Dement (N Y). 2018; 4:444-449. PMID: 30258973.
    View in: PubMed
  6. Rabin JS, Schultz AP, Hedden T, Viswanathan A, Marshall GA, Kilpatrick E, Klein H, Buckley RF, Yang HS, Properzi M, Rao V, Kirn DR, Papp KV, Rentz DM, Johnson KA, Sperling RA, Chhatwal JP. Interactive Associations of Vascular Risk and ß-Amyloid Burden With Cognitive Decline in Clinically Normal Elderly Individuals: Findings From the Harvard Aging Brain Study. JAMA Neurol. 2018 Sep 01; 75(9):1124-1131. PMID: 29799986.
    View in: PubMed
  7. Hanseeuw BJ, Jonas V, Jackson J, Betensky RA, Rentz DM, Johnson KA, Sperling RA, Donovan NJ. Association of anxiety with subcortical amyloidosis in cognitively normal older adults. Mol Psychiatry. 2018 Aug 16. PMID: 30116029.
    View in: PubMed
  8. Yang HS, Yu L, White CC, Chibnik LB, Chhatwal JP, Sperling RA, Bennett DA, Schneider JA, De Jager PL. Evaluation of TDP-43 proteinopathy and hippocampal sclerosis in relation to APOE e4 haplotype status: a community-based cohort study. Lancet Neurol. 2018 Sep; 17(9):773-781. PMID: 30093249.
    View in: PubMed
  9. Zott B, Busche MA, Sperling RA, Konnerth A. What Happens with the Circuit in Alzheimer's Disease in Mice and Humans? Annu Rev Neurosci. 2018 Jul 08; 41:277-297. PMID: 29986165.
    View in: PubMed
  10. Buckley RF, Mormino EC, Amariglio RE, Properzi MJ, Rabin JS, Lim YY, Papp KV, Jacobs HIL, Burnham S, Hanseeuw BJ, Doré V, Dobson A, Masters CL, Waller M, Rowe CC, Maruff P, Donohue MC, Rentz DM, Kirn D, Hedden T, Chhatwal J, Schultz AP, Johnson KA, Villemagne VL, Sperling RA. Sex, amyloid, and APOE e4 and risk of cognitive decline in preclinical Alzheimer's disease: Findings from three well-characterized cohorts. Alzheimers Dement. 2018 Sep; 14(9):1193-1203. PMID: 29803541.
    View in: PubMed
  11. Hanseeuw BJ, Betensky RA, Mormino EC, Schultz AP, Sepulcre J, Becker JA, Jacobs HIL, Buckley RF, LaPoint MR, Vannini P, Donovan NJ, Chhatwal JP, Marshall GA, Papp KV, Amariglio RE, Rentz DM, Sperling RA, Johnson KA. PET staging of amyloidosis using striatum. Alzheimers Dement. 2018 Oct; 14(10):1281-1292. PMID: 29792874.
    View in: PubMed
  12. Lee S, Zimmerman ME, Narkhede A, Nasrabady SE, Tosto G, Meier IB, Benzinger TLS, Marcus DS, Fagan AM, Fox NC, Cairns NJ, Holtzman DM, Buckles V, Ghetti B, McDade E, Martins RN, Saykin AJ, Masters CL, Ringman JM, F?rster S, Schofield PR, Sperling RA, Johnson KA, Chhatwal JP, Salloway S, Correia S, Jack CR, Weiner M, Bateman RJ, Morris JC, Mayeux R, Brickman AM. White matter hyperintensities and the mediating role of cerebral amyloid angiopathy in dominantly-inherited Alzheimer's disease. PLoS One. 2018; 13(5):e0195838. PMID: 29742105.
    View in: PubMed
  13. Munro CE, Donovan NJ, Amariglio RE, Papp KV, Marshall GA, Rentz DM, Pascual-Leone A, Sperling RA, Locascio JJ, Vannini P. The Impact of Awareness of and Concern About Memory Performance on the Prediction of Progression From Mild Cognitive Impairment to Alzheimer Disease Dementia. Am J Geriatr Psychiatry. 2018 Aug; 26(8):896-904. PMID: 29866588.
    View in: PubMed
  14. Chhatwal JP, Schultz AP, Johnson KA, Hedden T, Jaimes S, Benzinger TLS, Jack C, Ances BM, Ringman JM, Marcus DS, Ghetti B, Farlow MR, Danek A, Levin J, Yakushev I, Laske C, Koeppe RA, Galasko DR, Xiong C, Masters CL, Schofield PR, Kinnunen KM, Salloway S, Martins RN, McDade E, Cairns NJ, Buckles VD, Morris JC, Bateman R, Sperling RA. Preferential degradation of cognitive networks differentiates Alzheimer's disease from ageing. Brain. 2018 May 01; 141(5):1486-1500. PMID: 29522171.
    View in: PubMed
  15. Quiroz YT, Sperling RA, Norton DJ, Baena A, Arboleda-Velasquez JF, Cosio D, Schultz A, Lapoint M, Guzman-Velez E, Miller JB, Kim LA, Chen K, Tariot PN, Lopera F, Reiman EM, Johnson KA. Association Between Amyloid and Tau Accumulation in Young Adults With Autosomal Dominant Alzheimer Disease. JAMA Neurol. 2018 May 01; 75(5):548-556. PMID: 29435558.
    View in: PubMed
  16. Klinger RY, James OG, Borges-Neto S, Bisanar T, Li YJ, Qi W, Berger M, Terrando N, Newman MF, Doraiswamy PM, Mathew JP. 18F-florbetapir Positron Emission Tomography-determined Cerebral ß-Amyloid Deposition and Neurocognitive Performance after Cardiac Surgery. Anesthesiology. 2018 04; 128(4):728-744. PMID: 29389750.
    View in: PubMed
  17. Jack CR, Bennett DA, Blennow K, Carrillo MC, Dunn B, Haeberlein SB, Holtzman DM, Jagust W, Jessen F, Karlawish J, Liu E, Molinuevo JL, Montine T, Phelps C, Rankin KP, Rowe CC, Scheltens P, Siemers E, Snyder HM, Sperling R. NIA-AA Research Framework: Toward a biological definition of Alzheimer's disease. Alzheimers Dement. 2018 Apr; 14(4):535-562. PMID: 29653606.
    View in: PubMed
  18. Ge T, Sabuncu MR, Smoller JW, Sperling RA, Mormino EC. Dissociable influences of APOE e4 and polygenic risk of AD dementia on amyloid and cognition. Neurology. 2018 May 01; 90(18):e1605-e1612. PMID: 29592889.
    View in: PubMed
  19. Rabin JS, Perea RD, Buckley RF, Neal TE, Buckner RL, Johnson KA, Sperling RA, Hedden T. Global White Matter Diffusion Characteristics Predict Longitudinal Cognitive Change Independently of Amyloid Status in Clinically Normal Older Adults. Cereb Cortex. 2018 Feb 07. PMID: 29425267.
    View in: PubMed
  20. Jacobs HIL, Hedden T, Schultz AP, Sepulcre J, Perea RD, Amariglio RE, Papp KV, Rentz DM, Sperling RA, Johnson KA. Structural tract alterations predict downstream tau accumulation in amyloid-positive older individuals. Nat Neurosci. 2018 Mar; 21(3):424-431. PMID: 29403032.
    View in: PubMed
  21. Liu E, Wang D, Sperling R, Salloway S, Fox NC, Blennow K, Scheltens P, Schmidt ME, Streffer J, Novak G, Einstein S, Booth K, Ketter N, Brashear HR. Biomarker pattern of ARIA-E participants in phase 3 randomized clinical trials with bapineuzumab. Neurology. 2018 Mar 06; 90(10):e877-e886. PMID: 29429971.
    View in: PubMed
  22. Donovan NJ, Locascio JJ, Marshall GA, Gatchel J, Hanseeuw BJ, Rentz DM, Johnson KA, Sperling RA. Longitudinal Association of Amyloid Beta and Anxious-Depressive Symptoms in Cognitively Normal Older Adults. Am J Psychiatry. 2018 Jun 01; 175(6):530-537. PMID: 29325447.
    View in: PubMed
  23. Lee CM, Jacobs HIL, Marquié M, Becker JA, Andrea NV, Jin DS, Schultz AP, Frosch MP, Gómez-Isla T, Sperling RA, Johnson KA. 18F-Flortaucipir Binding in Choroid Plexus: Related to Race and Hippocampus Signal. J Alzheimers Dis. 2018; 62(4):1691-1702. PMID: 29614677.
    View in: PubMed
  24. Salloway SP, Sperling R, Fox NC, Sabbagh MN, Honig LS, Porsteinsson AP, Rofael H, Ketter N, Wang D, Liu E, Carr S, Black RS, Brashear HR. Long-Term Follow Up of Patients with Mild-to-Moderate Alzheimer's Disease Treated with Bapineuzumab in a Phase III, Open-Label, Extension Study. J Alzheimers Dis. 2018; 64(3):689-707. PMID: 29914022.
    View in: PubMed
  25. Aisen PS, Siemers E, Michelson D, Salloway S, Sampaio C, Carrillo MC, Sperling R, Doody R, Scheltens P, Bateman R, Weiner M, Vellas B. What Have We Learned from Expedition III and EPOCH Trials? Perspective of the CTAD Task Force. J Prev Alzheimers Dis. 2018; 5(3):171-174. PMID: 29972209.
    View in: PubMed
  26. Guzmán-Vélez E, Jaimes S, Aguirre-Acevedo DC, Norton DJ, Papp KV, Amariglio R, Rentz D, Baena A, Henao E, Tirado V, Muñoz C, Giraldo M, Sperling RA, Lopera F, Quiroz YT. A Three-Factor Structure of Cognitive Functioning Among Unimpaired Carriers and Non-Carriers of Autosomal-Dominant Alzheimer's Disease. J Alzheimers Dis. 2018; 65(1):107-115. PMID: 30040714.
    View in: PubMed
  27. Buckley RF, Hanseeuw B, Schultz AP, Vannini P, Aghjayan SL, Properzi MJ, Jackson JD, Mormino EC, Rentz DM, Sperling RA, Johnson KA, Amariglio RE. Region-Specific Association of Subjective Cognitive Decline With Tauopathy Independent of Global ß-Amyloid Burden. JAMA Neurol. 2017 Dec 01; 74(12):1455-1463. PMID: 28973551.
    View in: PubMed
  28. Orlovsky I, Huijbers W, Hanseeuw BJ, Mormino EC, Hedden T, Buckley RF, LaPoint M, Rabin JS, Rentz DM, Johnson KA, Sperling RA, Papp KV. The relationship between recall of recently versus remotely encoded famous faces and amyloidosis in clinically normal older adults. Alzheimers Dement (Amst). 2018; 10:121-129. PMID: 29780861.
    View in: PubMed
  29. Papp KV, Rentz DM, Orlovsky I, Sperling RA, Mormino EC. Optimizing the preclinical Alzheimer's cognitive composite with semantic processing: The PACC5. Alzheimers Dement (N Y). 2017 Nov; 3(4):668-677. PMID: 29264389.
    View in: PubMed
  30. Jackson JD, Rentz DM, Aghjayan SL, Buckley RF, Meneide TF, Sperling RA, Amariglio RE. Subjective cognitive concerns are associated with objective memory performance in Caucasian but not African-American persons. Age Ageing. 2017 Nov 01; 46(6):988-993. PMID: 29088363.
    View in: PubMed
  31. d'Oleire Uquillas F, Jacobs HIL, Hanseeuw B, Marshall GA, Properzi M, Schultz AP, LaPoint MR, Johnson KA, Sperling RA, Vannini P. Interactive versus additive relationships between regional cortical thinning and amyloid burden in predicting clinical decline in mild AD and MCI individuals. Neuroimage Clin. 2018; 17:388-396. PMID: 29159051.
    View in: PubMed
  32. Norton DJ, Amariglio R, Protas H, Chen K, Aguirre-Acevedo DC, Pulsifer B, Castrillon G, Tirado V, Munoz C, Tariot P, Langbaum JB, Reiman EM, Lopera F, Sperling RA, Quiroz YT. Subjective memory complaints in preclinical autosomal dominant Alzheimer disease. Neurology. 2017 Oct 03; 89(14):1464-1470. PMID: 28878053.
    View in: PubMed
  33. Huijbers W, Papp KV, LaPoint M, Wigman SE, Dagley A, Hedden T, Rentz DM, Schultz AP, Sperling RA. Age-Related Increases in Tip-of-the-tongue are Distinct from Decreases in Remembering Names: A Functional MRI Study. Cereb Cortex. 2017 09 01; 27(9):4339-4349. PMID: 27578492.
    View in: PubMed
  34. Aisen PS, Cummings J, Jack CR, Morris JC, Sperling R, Frölich L, Jones RW, Dowsett SA, Matthews BR, Raskin J, Scheltens P, Dubois B. On the path to 2025: understanding the Alzheimer's disease continuum. Alzheimers Res Ther. 2017 Aug 09; 9(1):60. PMID: 28793924.
    View in: PubMed
  35. Kinnunen KM, Cash DM, Poole T, Frost C, Benzinger TLS, Ahsan RL, Leung KK, Cardoso MJ, Modat M, Malone IB, Morris JC, Bateman RJ, Marcus DS, Goate A, Salloway SP, Correia S, Sperling RA, Chhatwal JP, Mayeux RP, Brickman AM, Martins RN, Farlow MR, Ghetti B, Saykin AJ, Jack CR, Schofield PR, McDade E, Weiner MW, Ringman JM, Thompson PM, Masters CL, Rowe CC, Rossor MN, Ourselin S, Fox NC. Presymptomatic atrophy in autosomal dominant Alzheimer's disease: A serial magnetic resonance imaging study. Alzheimers Dement. 2018 Jan; 14(1):43-53. PMID: 28738187.
    View in: PubMed
  36. Sepulcre J, Grothe MJ, Sabuncu M, Chhatwal J, Schultz AP, Hanseeuw B, El Fakhri G, Sperling R, Johnson KA. Hierarchical Organization of Tau and Amyloid Deposits in the Cerebral Cortex. JAMA Neurol. 2017 Jul 01; 74(7):813-820. PMID: 28558094.
    View in: PubMed
  37. Donohue MC, Sperling RA, Petersen R, Sun CK, Weiner MW, Aisen PS. Association Between Elevated Brain Amyloid and Subsequent Cognitive Decline Among Cognitively Normal Persons. JAMA. 2017 06 13; 317(22):2305-2316. PMID: 28609533.
    View in: PubMed
  38. Buckley RF, Schultz AP, Hedden T, Papp KV, Hanseeuw BJ, Marshall G, Sepulcre J, Smith EE, Rentz DM, Johnson KA, Sperling RA, Chhatwal JP. Functional network integrity presages cognitive decline in preclinical Alzheimer disease. Neurology. 2017 Jul 04; 89(1):29-37. PMID: 28592457.
    View in: PubMed
  39. Vannini P, Hanseeuw B, Munro CE, Amariglio RE, Marshall GA, Rentz DM, Pascual-Leone A, Johnson KA, Sperling RA. Anosognosia for memory deficits in mild cognitive impairment: Insight into the neural mechanism using functional and molecular imaging. Neuroimage Clin. 2017; 15:408-414. PMID: 28616381.
    View in: PubMed
  40. LaPoint MR, Chhatwal JP, Sepulcre J, Johnson KA, Sperling RA, Schultz AP. The association between tau PET and retrospective cortical thinning in clinically normal elderly. Neuroimage. 2017 08 15; 157:612-622. PMID: 28545932.
    View in: PubMed
  41. Haliburton JR, Kim SC, Clark IC, Sperling RA, Weitz DA, Abate AR. Efficient extraction of oil from droplet microfluidic emulsions. Biomicrofluidics. 2017 May; 11(3):034111. PMID: 28611871.
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  42. Dekhtyar M, Papp KV, Buckley R, Jacobs HIL, Schultz AP, Johnson KA, Sperling RA, Rentz DM. Neuroimaging markers associated with maintenance of optimal memory performance in late-life. Neuropsychologia. 2017 06; 100:164-170. PMID: 28472627.
    View in: PubMed
  43. Müller S, Preische O, Sohrabi HR, Gräber S, Jucker M, Dietzsch J, Ringman JM, Martins RN, McDade E, Schofield PR, Ghetti B, Rossor M, Graff-Radford NR, Levin J, Galasko D, Quaid KA, Salloway S, Xiong C, Benzinger T, Buckles V, Masters CL, Sperling R, Bateman RJ, Morris JC, Laske C. Decreased body mass index in the preclinical stage of autosomal dominant Alzheimer's disease. Sci Rep. 2017 04 27; 7(1):1225. PMID: 28450713.
    View in: PubMed
  44. White CC, Yang HS, Yu L, Chibnik LB, Dawe RJ, Yang J, Klein HU, Felsky D, Ramos-Miguel A, Arfanakis K, Honer WG, Sperling RA, Schneider JA, Bennett DA, De Jager PL. Identification of genes associated with dissociation of cognitive performance and neuropathological burden: Multistep analysis of genetic, epigenetic, and transcriptional data. PLoS Med. 2017 Apr; 14(4):e1002287. PMID: 28441426.
    View in: PubMed
  45. Hanseeuw BJ, Betensky RA, Schultz AP, Papp KV, Mormino EC, Sepulcre J, Bark JS, Cosio DM, LaPoint M, Chhatwal JP, Rentz DM, Sperling RA, Johnson KA. Fluorodeoxyglucose metabolism associated with tau-amyloid interaction predicts memory decline. Ann Neurol. 2017 Apr; 81(4):583-596. PMID: 28253546.
    View in: PubMed
  46. Vannini P, Hanseeuw B, Munro CE, Amariglio RE, Marshall GA, Rentz DM, Pascual-Leone A, Johnson KA, Sperling RA. Hippocampal hypometabolism in older adults with memory complaints and increased amyloid burden. Neurology. 2017 May 02; 88(18):1759-1767. PMID: 28381517.
    View in: PubMed
  47. Vannini P, Amariglio R, Hanseeuw B, Johnson KA, McLaren DG, Chhatwal J, Pascual-Leone A, Rentz D, Sperling RA. Memory self-awareness in the preclinical and prodromal stages of Alzheimer's disease. Neuropsychologia. 2017 05; 99:343-349. PMID: 28385579.
    View in: PubMed
  48. Rentz DM, Mormino EC, Papp KV, Betensky RA, Sperling RA, Johnson KA. Cognitive resilience in clinical and preclinical Alzheimer's disease: the Association of Amyloid and Tau Burden on cognitive performance. Brain Imaging Behav. 2017 04; 11(2):383-390. PMID: 27738998.
    View in: PubMed
  49. Tarrant SD, Bardach SH, Bates K, Nichols H, Towner J, Tamatha C, Caban-Holt A, Van-Eldik LJ, Murphy RR, Sperling R, Jicha GA. The Effectiveness of Small-group Community-based Information Sessions on Clinical Trial Recruitment for Secondary Prevention of Alzheimer's Disease. Alzheimer Dis Assoc Disord. 2017 Apr-Jun; 31(2):141-145. PMID: 27213625.
    View in: PubMed
  50. Sepulcre J, Sabuncu MR, Li Q, El Fakhri G, Sperling R, Johnson KA. Tau and amyloid ß proteins distinctively associate to functional network changes in the aging brain. Alzheimers Dement. 2017 Nov; 13(11):1261-1269. PMID: 28366797.
    View in: PubMed
  51. Schultz AP, Chhatwal JP, Hedden T, Mormino EC, Hanseeuw BJ, Sepulcre J, Huijbers W, LaPoint M, Buckley RF, Johnson KA, Sperling RA. Phases of Hyperconnectivity and Hypoconnectivity in the Default Mode and Salience Networks Track with Amyloid and Tau in Clinically Normal Individuals. J Neurosci. 2017 Apr 19; 37(16):4323-4331. PMID: 28314821.
    View in: PubMed
  52. Papp KV, Rentz DM, Mormino EC, Schultz AP, Amariglio RE, Quiroz Y, Johnson KA, Sperling RA. Cued memory decline in biomarker-defined preclinical Alzheimer disease. Neurology. 2017 Apr 11; 88(15):1431-1438. PMID: 28283594.
    View in: PubMed
  53. Mormino EC, Papp KV, Rentz DM, Donohue MC, Amariglio R, Quiroz YT, Chhatwal J, Marshall GA, Donovan N, Jackson J, Gatchel JR, Hanseeuw BJ, Schultz AP, Aisen PS, Johnson KA, Sperling RA. Early and late change on the preclinical Alzheimer's cognitive composite in clinically normal older individuals with elevated amyloid ß. Alzheimers Dement. 2017 Sep; 13(9):1004-1012. PMID: 28253478.
    View in: PubMed
  54. Gatchel JR, Donovan NJ, Locascio JJ, Becker JA, Rentz DM, Sperling RA, Johnson KA, Marshall GA. Regional 18F-Fluorodeoxyglucose Hypometabolism is Associated with Higher Apathy Scores Over Time in Early Alzheimer Disease. Am J Geriatr Psychiatry. 2017 Jul; 25(7):683-693. PMID: 28410856.
    View in: PubMed
  55. Gatchel JR, Donovan NJ, Locascio JJ, Schultz AP, Becker JA, Chhatwal J, Papp KV, Amariglio RE, Rentz DM, Blacker D, Sperling RA, Johnson KA, Marshall GA. Depressive Symptoms and Tau Accumulation in the Inferior Temporal Lobe and Entorhinal Cortex in Cognitively Normal Older Adults: A Pilot Study. J Alzheimers Dis. 2017; 59(3):975-985. PMID: 28697559.
    View in: PubMed
  56. Dumurgier J, Hanseeuw BJ, Hatling FB, Judge KA, Schultz AP, Chhatwal JP, Blacker D, Sperling RA, Johnson KA, Hyman BT, Gómez-Isla T. Alzheimer's Disease Biomarkers and Future Decline in Cognitive Normal Older Adults. J Alzheimers Dis. 2017; 60(4):1451-1459. PMID: 29036824.
    View in: PubMed
  57. Aisen P, Touchon J, Amariglio R, Andrieu S, Bateman R, Breitner J, Donohue M, Dunn B, Doody R, Fox N, Gauthier S, Grundman M, Hendrix S, Ho C, Isaac M, Raman R, Rosenberg P, Schindler R, Schneider L, Sperling R, Tariot P, Welsh-Bohmer K, Weiner M, Vellas B. EU/US/CTAD Task Force: Lessons Learned from Recent and Current Alzheimer's Prevention Trials. J Prev Alzheimers Dis. 2017; 4(2):116-124. PMID: 29186281.
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  58. Buckley RF, Sparks KP, Papp KV, Dekhtyar M, Martin C, Burnham S, Sperling RA, Rentz DM. Computerized Cognitive Testing for Use in Clinical Trials: A Comparison of the NIH Toolbox and Cogstate C3 Batteries. J Prev Alzheimers Dis. 2017; 4(1):3-11. PMID: 29188853.
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  59. Touchon J, Rosenbaum J, Aisen P, Andrieu S, Carrillo MC, Ceccaldi M, Dartiques JF, Feldman H, Gabelle A, Isaac M, Fitten LJ, Sperling RA, Vellas B, Tariot P, Weiner M. Editorial: Collaborative Efforts to Prevent Alzheimer's Disease. J Nutr Health Aging. 2017; 21(10):1072-1074. PMID: 29188862.
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  60. Marshall GA, Aghjayan SL, Dekhtyar M, Locascio JJ, Jethwani K, Amariglio RE, Johnson KA, Sperling RA, Rentz DM. Activities of daily living measured by the Harvard Automated Phone Task track with cognitive decline over time in non-demented elderly. J Prev Alzheimers Dis. 2017; 4(2):81-86. PMID: 29124043.
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  61. Prckovska V, Huijbers W, Schultz A, Ortiz-Teran L, Peña-Gomez C, Villoslada P, Johnson K, Sperling R, Sepulcre J. Epicenters of dynamic connectivity in the adaptation of the ventral visual system. Hum Brain Mapp. 2017 04; 38(4):1965-1976. PMID: 28029725.
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  62. Donovan NJ, Okereke OI, Vannini P, Amariglio RE, Rentz DM, Marshall GA, Johnson KA, Sperling RA. Association of Higher Cortical Amyloid Burden With Loneliness in Cognitively Normal Older Adults. JAMA Psychiatry. 2016 Dec 01; 73(12):1230-1237. PMID: 27806159.
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  63. Dhilla Albers A, Asafu-Adjei J, Delaney MK, Kelly KE, Gomez-Isla T, Blacker D, Johnson KA, Sperling RA, Hyman BT, Betensky RA, Hastings L, Albers MW. Episodic memory of odors stratifies Alzheimer biomarkers in normal elderly. Ann Neurol. 2016 12; 80(6):846-857. PMID: 27696605.
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  64. Molinuevo JL, Rabin LA, Amariglio R, Buckley R, Dubois B, Ellis KA, Ewers M, Hampel H, Klöppel S, Rami L, Reisberg B, Saykin AJ, Sikkes S, Smart CM, Snitz BE, Sperling R, van der Flier WM, Wagner M, Jessen F. Implementation of subjective cognitive decline criteria in research studies. Alzheimers Dement. 2017 Mar; 13(3):296-311. PMID: 27825022.
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  65. Gomperts SN, Locascio JJ, Makaretz SJ, Schultz A, Caso C, Vasdev N, Sperling R, Growdon JH, Dickerson BC, Johnson K. Tau Positron Emission Tomographic Imaging in the Lewy Body Diseases. JAMA Neurol. 2016 Nov 01; 73(11):1334-1341. PMID: 27654968.
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  66. Williams VJ, Hayes JP, Forman DE, Salat DH, Sperling RA, Verfaellie M, Hayes SM. Cardiorespiratory fitness is differentially associated with cortical thickness in young and older adults. Neuroimage. 2017 02 01; 146:1084-1092. PMID: 27989841.
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  67. Aghjayan SL, Buckley RF, Vannini P, Rentz DM, Jackson JD, Sperling RA, Johnson KA, Amariglio RE. The influence of demographic factors on subjective cognitive concerns and beta-amyloid. Int Psychogeriatr. 2017 04; 29(4):645-652. PMID: 27724996.
    View in: PubMed
  68. Shah H, Albanese E, Duggan C, Rudan I, Langa KM, Carrillo MC, Chan KY, Joanette Y, Prince M, Rossor M, Saxena S, Snyder HM, Sperling R, Varghese M, Wang H, Wortmann M, Dua T. Research priorities to reduce the global burden of dementia by 2025. Lancet Neurol. 2016 Nov; 15(12):1285-1294. PMID: 27751558.
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  137. Stephenson D, Perry D, Bens C, Bain LJ, Berry D, Krams M, Sperling R, Dilts D, Luthman J, Hanna D, McKew J, Temple R, Fields FO, Salloway S, Katz R. Charting a path toward combination therapy for Alzheimer's disease. Expert Rev Neurother. 2015 Jan; 15(1):107-13. PMID: 25540951.
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  139. Cavedo E, Lista S, Khachaturian Z, Aisen P, Amouyel P, Herholz K, Jack CR, Sperling R, Cummings J, Blennow K, O'Bryant S, Frisoni GB, Khachaturian A, Kivipelto M, Klunk W, Broich K, Andrieu S, de Schotten MT, Mangin JF, Lammertsma AA, Johnson K, Teipel S, Drzezga A, Bokde A, Colliot O, Bakardjian H, Zetterberg H, Dubois B, Vellas B, Schneider LS, Hampel H. The Road Ahead to Cure Alzheimer's Disease: Development of Biological Markers and Neuroimaging Methods for Prevention Trials Across all Stages and Target Populations. J Prev Alzheimers Dis. 2014 Dec; 1(3):181-202. PMID: 26478889.
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  141. Sperling R, Mormino E, Johnson K. The evolution of preclinical Alzheimer's disease: implications for prevention trials. Neuron. 2014 Nov 05; 84(3):608-22. PMID: 25442939; PMCID: PMC4285623.
  142. Mormino EC, Betensky RA, Hedden T, Schultz AP, Amariglio RE, Rentz DM, Johnson KA, Sperling RA. Synergistic effect of ß-amyloid and neurodegeneration on cognitive decline in clinically normal individuals. JAMA Neurol. 2014 Nov; 71(11):1379-85. PMID: 25222039; PMCID: PMC4293023.
  143. Hedden T, Schultz AP, Rieckmann A, Mormino EC, Johnson KA, Sperling RA, Buckner RL. Multiple Brain Markers are Linked to Age-Related Variation in Cognition. Cereb Cortex. 2016 Apr; 26(4):1388-400. PMID: 25316342; PMCID: PMC4785941 [Available on 04/01/17].
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  146. Thomas JB, Brier MR, Bateman RJ, Snyder AZ, Benzinger TL, Xiong C, Raichle M, Holtzman DM, Sperling RA, Mayeux R, Ghetti B, Ringman JM, Salloway S, McDade E, Rossor MN, Ourselin S, Schofield PR, Masters CL, Martins RN, Weiner MW, Thompson PM, Fox NC, Koeppe RA, Jack CR, Mathis CA, Oliver A, Blazey TM, Moulder K, Buckles V, Hornbeck R, Chhatwal J, Schultz AP, Goate AM, Fagan AM, Cairns NJ, Marcus DS, Morris JC, Ances BM. Functional connectivity in autosomal dominant and late-onset Alzheimer disease. JAMA Neurol. 2014 Sep; 71(9):1111-22. PMID: 25069482.
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  150. Ryman DC, Acosta-Baena N, Aisen PS, Bird T, Danek A, Fox NC, Goate A, Frommelt P, Ghetti B, Langbaum JB, Lopera F, Martins R, Masters CL, Mayeux RP, McDade E, Moreno S, Reiman EM, Ringman JM, Salloway S, Schofield PR, Sperling R, Tariot PN, Xiong C, Morris JC, Bateman RJ. Symptom onset in autosomal dominant Alzheimer disease: a systematic review and meta-analysis. Neurology. 2014 Jul 15; 83(3):253-60. PMID: 24928124; PMCID: PMC4117367.
  151. McLaren DG, Sperling RA, Atri A. Flexible modulation of network connectivity related to cognition in Alzheimer's disease. Neuroimage. 2014 Oct 15; 100:544-57. PMID: 24852459.
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  152. Papp KV, Amariglio RE, Dekhtyar M, Roy K, Wigman S, Bamfo R, Sherman J, Sperling RA, Rentz DM. Development of a psychometrically equivalent short form of the Face-Name Associative Memory Exam for use along the early Alzheimer's disease trajectory. Clin Neuropsychol. 2014; 28(5):771-85. PMID: 24815535.
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  153. Jessen F, Amariglio RE, van Boxtel M, Breteler M, Ceccaldi M, Chételat G, Dubois B, Dufouil C, Ellis KA, van der Flier WM, Glodzik L, van Harten AC, de Leon MJ, McHugh P, Mielke MM, Molinuevo JL, Mosconi L, Osorio RS, Perrotin A, Petersen RC, Rabin LA, Rami L, Reisberg B, Rentz DM, Sachdev PS, de la Sayette V, Saykin AJ, Scheltens P, Shulman MB, Slavin MJ, Sperling RA, Stewart R, Uspenskaya O, Vellas B, Visser PJ, Wagner M. A conceptual framework for research on subjective cognitive decline in preclinical Alzheimer's disease. Alzheimers Dement. 2014 Nov; 10(6):844-52. PMID: 24798886.
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  155. Salloway S, Sperling R, Brashear HR. Phase 3 trials of solanezumab and bapineuzumab for Alzheimer's disease. N Engl J Med. 2014 04 10; 370(15):1460. PMID: 24724181.
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  156. Huijbers W, Mormino EC, Wigman SE, Ward AM, Vannini P, McLaren DG, Becker JA, Schultz AP, Hedden T, Johnson KA, Sperling RA. Amyloid deposition is linked to aberrant entorhinal activity among cognitively normal older adults. J Neurosci. 2014 Apr 09; 34(15):5200-10. PMID: 24719099; PMCID: PMC3983800.
  157. Serrano-Pozo A, Qian J, Monsell SE, Blacker D, Gómez-Isla T, Betensky RA, Growdon JH, Johnson KA, Frosch MP, Sperling RA, Hyman BT. Mild to moderate Alzheimer dementia with insufficient neuropathological changes. Ann Neurol. 2014 Apr; 75(4):597-601. PMID: 24585367.
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  158. Marder TJ, Flores VL, Bolo NR, Hoogenboom WS, Simonson DC, Jacobson AM, Foote SE, Shenton ME, Sperling RA, Musen G. Task-induced brain activity patterns in type 2 diabetes: a potential biomarker for cognitive decline. Diabetes. 2014 Sep; 63(9):3112-9. PMID: 24705405.
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  159. Feldman HH, Haas M, Gandy S, Schoepp DD, Cross AJ, Mayeux R, Sperling RA, Fillit H, van de Hoef DL, Dougal S, Nye JS. Alzheimer's disease research and development: a call for a new research roadmap. Ann N Y Acad Sci. 2014 Apr; 1313:1-16. PMID: 24754377.
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  161. Doraiswamy PM, Sperling RA, Johnson K, Reiman EM, Wong TZ, Sabbagh MN, Sadowsky CH, Fleisher AS, Carpenter A, Joshi AD, Lu M, Grundman M, Mintun MA, Skovronsky DM, Pontecorvo MJ. Florbetapir F 18 amyloid PET and 36-month cognitive decline: a prospective multicenter study. Mol Psychiatry. 2014 Sep; 19(9):1044-51. PMID: 24614494; PMCID: PMC4195975.
  162. Fagan AM, Xiong C, Jasielec MS, Bateman RJ, Goate AM, Benzinger TL, Ghetti B, Martins RN, Masters CL, Mayeux R, Ringman JM, Rossor MN, Salloway S, Schofield PR, Sperling RA, Marcus D, Cairns NJ, Buckles VD, Ladenson JH, Morris JC, Holtzman DM. Longitudinal change in CSF biomarkers in autosomal-dominant Alzheimer's disease. Sci Transl Med. 2014 Mar 05; 6(226):226ra30. PMID: 24598588.
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  163. Cohen SI, Rajah L, Yoon CH, Buell AK, White DA, Sperling RA, Vendruscolo M, Terentjev EM, Dobson CM, Weitz DA, Knowles TP. Spatial propagation of protein polymerization. Phys Rev Lett. 2014 Mar 07; 112(9):098101. PMID: 24655282.
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  165. Salloway S, Sperling R, Fox NC, Blennow K, Klunk W, Raskind M, Sabbagh M, Honig LS, Porsteinsson AP, Ferris S, Reichert M, Ketter N, Nejadnik B, Guenzler V, Miloslavsky M, Wang D, Lu Y, Lull J, Tudor IC, Liu E, Grundman M, Yuen E, Black R, Brashear HR. Two phase 3 trials of bapineuzumab in mild-to-moderate Alzheimer's disease. N Engl J Med. 2014 Jan 23; 370(4):322-33. PMID: 24450891.
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  168. Marshall GA, Zoller AS, Kelly KE, Amariglio RE, Locascio JJ, Johnson KA, Sperling RA, Rentz DM. Everyday cognition scale items that best discriminate between and predict progression from clinically normal to mild cognitive impairment. Curr Alzheimer Res. 2014; 11(9):853-61. PMID: 25274110; PMCID: PMC4247808.
  169. Zoller AS, Gaal IM, Royer CA, Locascio JJ, Amariglio RE, Blacker D, Okereke OI, Johnson KA, Sperling RA, Rentz DM, Marshall GA. SIST-M-IR activities of daily living items that best discriminate clinically normal elderly from those with mild cognitive impairment. Curr Alzheimer Res. 2014; 11(8):785-91. PMID: 25212917; PMCID: PMC4163929.
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  172. Benzinger TL, Blazey T, Jack CR, Koeppe RA, Su Y, Xiong C, Raichle ME, Snyder AZ, Ances BM, Bateman RJ, Cairns NJ, Fagan AM, Goate A, Marcus DS, Aisen PS, Christensen JJ, Ercole L, Hornbeck RC, Farrar AM, Aldea P, Jasielec MS, Owen CJ, Xie X, Mayeux R, Brickman A, McDade E, Klunk W, Mathis CA, Ringman J, Thompson PM, Ghetti B, Saykin AJ, Sperling RA, Johnson KA, Salloway S, Correia S, Schofield PR, Masters CL, Rowe C, Villemagne VL, Martins R, Ourselin S, Rossor MN, Fox NC, Cash DM, Weiner MW, Holtzman DM, Buckles VD, Moulder K, Morris JC. Regional variability of imaging biomarkers in autosomal dominant Alzheimer's disease. Proc Natl Acad Sci U S A. 2013 Nov 19; 110(47):E4502-9. PMID: 24194552.
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  174. Cash DM, Ridgway GR, Liang Y, Ryan NS, Kinnunen KM, Yeatman T, Malone IB, Benzinger TL, Jack CR, Thompson PM, Ghetti BF, Saykin AJ, Masters CL, Ringman JM, Salloway SP, Schofield PR, Sperling RA, Cairns NJ, Marcus DS, Xiong C, Bateman RJ, Morris JC, Rossor MN, Ourselin S, Fox NC. The pattern of atrophy in familial Alzheimer disease: volumetric MRI results from the DIAN study. Neurology. 2013 Oct 15; 81(16):1425-33. PMID: 24049139; PMCID: PMC3806583.
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  176. Johnson KA, Sperling RA, Sepulcre J. Functional connectivity in Alzheimer's disease: measurement and meaning. Biol Psychiatry. 2013 Sep 01; 74(5):318-9. PMID: 23932342.
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  177. Frisoni GB, Bocchetta M, Chételat G, Rabinovici GD, de Leon MJ, Kaye J, Reiman EM, Scheltens P, Barkhof F, Black SE, Brooks DJ, Carrillo MC, Fox NC, Herholz K, Nordberg A, Jack CR, Jagust WJ, Johnson KA, Rowe CC, Sperling RA, Thies W, Wahlund LO, Weiner MW, Pasqualetti P, Decarli C. Imaging markers for Alzheimer disease: which vs how. Neurology. 2013 Jul 30; 81(5):487-500. PMID: 23897875.
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  179. Donovan NJ, Wadsworth LP, Lorius N, Locascio JJ, Rentz DM, Johnson KA, Sperling RA, Marshall GA. Regional cortical thinning predicts worsening apathy and hallucinations across the Alzheimer disease spectrum. Am J Geriatr Psychiatry. 2014 Nov; 22(11):1168-79. PMID: 23890751; PMCID: PMC3960369.
  180. Salmon DP, Ferris SH, Thomas RG, Sano M, Cummings JL, Sperling RA, Petersen RC, Aisen PS. Age and apolipoprotein E genotype influence rate of cognitive decline in nondemented elderly. Neuropsychology. 2013 Jul; 27(4):391-401. PMID: 23876113; PMCID: PMC3831285.
  181. Vellas B, Carrillo MC, Sampaio C, Brashear HR, Siemers E, Hampel H, Schneider LS, Weiner M, Doody R, Khachaturian Z, Cedarbaum J, Grundman M, Broich K, Giacobini E, Dubois B, Sperling R, Wilcock GK, Fox N, Scheltens P, Touchon J, Hendrix S, Andrieu S, Aisen P. Designing drug trials for Alzheimer's disease: what we have learned from the release of the phase III antibody trials: a report from the EU/US/CTAD Task Force. Alzheimers Dement. 2013 Jul; 9(4):438-44. PMID: 23809364.
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  182. Sepulcre J, Sabuncu MR, Becker A, Sperling R, Johnson KA. In vivo characterization of the early states of the amyloid-beta network. Brain. 2013 Jul; 136(Pt 7):2239-52. PMID: 23801740; PMCID: PMC3692037.
  183. Bradshaw EM, Chibnik LB, Keenan BT, Ottoboni L, Raj T, Tang A, Rosenkrantz LL, Imboywa S, Lee M, Von Korff A, Morris MC, Evans DA, Johnson K, Sperling RA, Schneider JA, Bennett DA, De Jager PL. CD33 Alzheimer's disease locus: altered monocyte function and amyloid biology. Nat Neurosci. 2013 Jul; 16(7):848-50. PMID: 23708142.
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  184. Barakos J, Sperling R, Salloway S, Jack C, Gass A, Fiebach JB, Tampieri D, Melançon D, Miaux Y, Rippon G, Black R, Lu Y, Brashear HR, Arrighi HM, Morris KA, Grundman M. MR imaging features of amyloid-related imaging abnormalities. AJNR Am J Neuroradiol. 2013 Oct; 34(10):1958-65. PMID: 23578674.
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  185. Sperling R, Johnson K. Biomarkers of Alzheimer disease: current and future applications to diagnostic criteria. Continuum (Minneap Minn). 2013 Apr; 19(2 Dementia):325-38. PMID: 23558480.
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  186. Werring DJ, Sperling R. Inflammatory cerebral amyloid angiopathy and amyloid-modifying therapies: variations on the same ARIA? Ann Neurol. 2013 Apr; 73(4):439-41. PMID: 23526685.
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  187. Ward AM, Schultz AP, Huijbers W, Van Dijk KR, Hedden T, Sperling RA. The parahippocampal gyrus links the default-mode cortical network with the medial temporal lobe memory system. Hum Brain Mapp. 2014 Mar; 35(3):1061-73. PMID: 23404748; PMCID: PMC3773261.
  188. Carrillo MC, Brashear HR, Logovinsky V, Ryan JM, Feldman HH, Siemers ER, Abushakra S, Hartley DM, Petersen RC, Khachaturian AS, Sperling RA. Can we prevent Alzheimer's disease? Secondary "prevention" trials in Alzheimer's disease. Alzheimers Dement. 2013 Mar; 9(2):123-131.e1. PMID: 23411394.
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  189. Huijbers W, Schultz AP, Vannini P, McLaren DG, Wigman SE, Ward AM, Hedden T, Sperling RA. The encoding/retrieval flip: interactions between memory performance and memory stage and relationship to intrinsic cortical networks. J Cogn Neurosci. 2013 Jul; 25(7):1163-79. PMID: 23384193; PMCID: PMC3730829.
  190. Yang T, Hong S, O'Malley T, Sperling RA, Walsh DM, Selkoe DJ. New ELISAs with high specificity for soluble oligomers of amyloid ß-protein detect natural Aß oligomers in human brain but not CSF. Alzheimers Dement. 2013 Mar; 9(2):99-112. PMID: 23375565; PMCID: PMC3604133.
  191. Johnson KA, Sperling RA, Gidicsin CM, Carmasin JS, Maye JE, Coleman RE, Reiman EM, Sabbagh MN, Sadowsky CH, Fleisher AS, Murali Doraiswamy P, Carpenter AP, Clark CM, Joshi AD, Lu M, Grundman M, Mintun MA, Pontecorvo MJ, Skovronsky DM. Florbetapir (F18-AV-45) PET to assess amyloid burden in Alzheimer's disease dementia, mild cognitive impairment, and normal aging. Alzheimers Dement. 2013 Oct; 9(5 Suppl):S72-83. PMID: 23375563.
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  193. Sperling RA, Karlawish J, Johnson KA. Preclinical Alzheimer disease-the challenges ahead. Nat Rev Neurol. 2013 01; 9(1):54-8. PMID: 23183885.
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  195. Quiroz YT, Stern CE, Reiman EM, Brickhouse M, Ruiz A, Sperling RA, Lopera F, Dickerson BC. Cortical atrophy in presymptomatic Alzheimer's disease presenilin 1 mutation carriers. J Neurol Neurosurg Psychiatry. 2013 May; 84(5):556-61. PMID: 23134660; PMCID: PMC3632663.
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  199. Desikan RS, McEvoy LK, Holland D, Thompson WK, Brewer JB, Aisen PS, Andreassen OA, Hyman BT, Sperling RA, Dale AM. Apolipoprotein E epsilon4 does not modulate amyloid-ß-associated neurodegeneration in preclinical Alzheimer disease. AJNR Am J Neuroradiol. 2013 Mar; 34(3):505-10. PMID: 22976236; PMCID: PMC4041629.
  200. Huijbers W, Vannini P, Sperling RA, C M P, Cabeza R, Daselaar SM. Explaining the encoding/retrieval flip: memory-related deactivations and activations in the posteromedial cortex. Neuropsychologia. 2012 Dec; 50(14):3764-74. PMID: 22982484; PMCID: PMC3811140.
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  203. Amariglio RE, Becker JA, Carmasin J, Wadsworth LP, Lorius N, Sullivan C, Maye JE, Gidicsin C, Pepin LC, Sperling RA, Johnson KA, Rentz DM. Subjective cognitive complaints and amyloid burden in cognitively normal older individuals. Neuropsychologia. 2012 Oct; 50(12):2880-6. PMID: 22940426; PMCID: PMC3473106.
  204. Sperling RA, Johnson KA, Doraiswamy PM, Reiman EM, Fleisher AS, Sabbagh MN, Sadowsky CH, Carpenter A, Davis MD, Lu M, Flitter M, Joshi AD, Clark CM, Grundman M, Mintun MA, Skovronsky DM, Pontecorvo MJ. Amyloid deposition detected with florbetapir F 18 ((18)F-AV-45) is related to lower episodic memory performance in clinically normal older individuals. Neurobiol Aging. 2013 Mar; 34(3):822-31. PMID: 22878163.
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  205. Doraiswamy PM, Sperling RA, Coleman RE, Johnson KA, Reiman EM, Davis MD, Grundman M, Sabbagh MN, Sadowsky CH, Fleisher AS, Carpenter A, Clark CM, Joshi AD, Mintun MA, Skovronsky DM, Pontecorvo MJ. Amyloid-ß assessed by florbetapir F 18 PET and 18-month cognitive decline: a multicenter study. Neurology. 2012 Oct 16; 79(16):1636-44. PMID: 22786606.
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  207. Desikan RS, McEvoy LK, Thompson WK, Holland D, Brewer JB, Aisen PS, Sperling RA, Dale AM. Amyloid-ß--associated clinical decline occurs only in the presence of elevated P-tau. Arch Neurol. 2012 Jun; 69(6):709-13. PMID: 22529247.
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  208. Fleisher AS, Chen K, Liu X, Ayutyanont N, Roontiva A, Thiyyagura P, Protas H, Joshi AD, Sabbagh M, Sadowsky CH, Sperling RA, Clark CM, Mintun MA, Pontecorvo MJ, Coleman RE, Doraiswamy PM, Johnson KA, Carpenter AP, Skovronsky DM, Reiman EM. Apolipoprotein E e4 and age effects on florbetapir positron emission tomography in healthy aging and Alzheimer disease. Neurobiol Aging. 2013 Jan; 34(1):1-12. PMID: 22633529.
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  209. Vannini P, Hedden T, Huijbers W, Ward A, Johnson KA, Sperling RA. The ups and downs of the posteromedial cortex: age- and amyloid-related functional alterations of the encoding/retrieval flip in cognitively normal older adults. Cereb Cortex. 2013 Jun; 23(6):1317-28. PMID: 22586140; PMCID: PMC3643714.
  210. DeCarli C, Kawas C, Morrison JH, Reuter-Lorenz PA, Sperling RA, Wright CB. Session II: Mechanisms of age-related cognitive change and targets for intervention: neural circuits, networks, and plasticity. J Gerontol A Biol Sci Med Sci. 2012 Jun; 67(7):747-53. PMID: 22570135; PMCID: PMC3732094.
  211. Johnson KA, Fox NC, Sperling RA, Klunk WE. Brain imaging in Alzheimer disease. Cold Spring Harb Perspect Med. 2012 Apr; 2(4):a006213. PMID: 22474610; PMCID: PMC3312396.
  212. McLaren DG, Sreenivasan A, Diamond EL, Mitchell MB, Van Dijk KR, Deluca AN, O'Brien JL, Rentz DM, Sperling RA, Atri A. Tracking cognitive change over 24 weeks with longitudinal functional magnetic resonance imaging in Alzheimer's disease. Neurodegener Dis. 2012; 9(4):176-86. PMID: 22456451; PMCID: PMC3369254.
  213. Amariglio RE, Frishe K, Olson LE, Wadsworth LP, Lorius N, Sperling RA, Rentz DM. Validation of the Face Name Associative Memory Exam in cognitively normal older individuals. J Clin Exp Neuropsychol. 2012; 34(6):580-7. PMID: 22765048; PMCID: PMC3391747.
  214. Vannini P, Hedden T, Sullivan C, Sperling RA. Differential functional response in the posteromedial cortices and hippocampus to stimulus repetition during successful memory encoding. Hum Brain Mapp. 2013 Jul; 34(7):1568-78. PMID: 22344847; PMCID: PMC3432294.
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  216. Sperling R, Salloway S, Brooks DJ, Tampieri D, Barakos J, Fox NC, Raskind M, Sabbagh M, Honig LS, Porsteinsson AP, Lieberburg I, Arrighi HM, Morris KA, Lu Y, Liu E, Gregg KM, Brashear HR, Kinney GG, Black R, Grundman M. Amyloid-related imaging abnormalities in patients with Alzheimer's disease treated with bapineuzumab: a retrospective analysis. Lancet Neurol. 2012 Mar; 11(3):241-9. PMID: 22305802; PMCID: PMC4063417.
  217. Villemagne VL, Klunk WE, Mathis CA, Rowe CC, Brooks DJ, Hyman BT, Ikonomovic MD, Ishii K, Jack CR, Jagust WJ, Johnson KA, Koeppe RA, Lowe VJ, Masters CL, Montine TJ, Morris JC, Nordberg A, Petersen RC, Reiman EM, Selkoe DJ, Sperling RA, Van Laere K, Weiner MW, Drzezga A. Aß Imaging: feasible, pertinent, and vital to progress in Alzheimer's disease. Eur J Nucl Med Mol Imaging. 2012 Feb; 39(2):209-19. PMID: 22218879; PMCID: PMC3261395.
  218. Sperling RA, Johnson KA. Dementia: new criteria but no new treatments. Lancet Neurol. 2012 Jan; 11(1):4-5. PMID: 22172609.
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  219. Chhatwal JP, Sperling RA. Functional MRI of mnemonic networks across the spectrum of normal aging, mild cognitive impairment, and Alzheimer's disease. J Alzheimers Dis. 2012; 31 Suppl 3:S155-67. PMID: 22890098; PMCID: PMC3736339.
  220. Sperling R, Johnson K. To sleep, perchance to delay dementia. Arch Neurol. 2012 Jan; 69(1):118-20. PMID: 22232352.
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  221. Holtzman DM, Goate A, Kelly J, Sperling R. Mapping the road forward in Alzheimer's disease. Sci Transl Med. 2011 Dec 21; 3(114):114ps48. PMID: 22190237.
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  222. Sabuncu MR, Buckner RL, Smoller JW, Lee PH, Fischl B, Sperling RA. The association between a polygenic Alzheimer score and cortical thickness in clinically normal subjects. Cereb Cortex. 2012 Nov; 22(11):2653-61. PMID: 22169231.
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  223. Reiman EM, McKhann GM, Albert MS, Sperling RA, Petersen RC, Blacker D. Clinical impact of updated diagnostic and research criteria for Alzheimer's disease. J Clin Psychiatry. 2011 Dec; 72(12):e37. PMID: 22244033; PMCID: PMC4028820.
  224. Sperling R. Potential of functional MRI as a biomarker in early Alzheimer's disease. Neurobiol Aging. 2011 Dec; 32 Suppl 1:S37-43. PMID: 22078171; PMCID: PMC3233699.
  225. Sperling RA, Jack CR, Aisen PS. Testing the right target and right drug at the right stage. Sci Transl Med. 2011 Nov 30; 3(111):111cm33. PMID: 22133718; PMCID: PMC3752906.
  226. Putcha D, Brickhouse M, O'Keefe K, Sullivan C, Rentz D, Marshall G, Dickerson B, Sperling R. Hippocampal hyperactivation associated with cortical thinning in Alzheimer's disease signature regions in non-demented elderly adults. J Neurosci. 2011 Nov 30; 31(48):17680-8. PMID: 22131428; PMCID: PMC3289551.
  227. Hurko O, Black SE, Doody R, Doraiswamy PM, Gamst A, Kaye J, Obisesan TO, Rusinek H, Scharre D, Sperling R, Weiner MW, Green RC. The ADNI Publication Policy: commensurate recognition of critical contributors who are not authors. Neuroimage. 2012 Feb 15; 59(4):4196-200. PMID: 22100665; PMCID: PMC3676932.
  228. Amariglio RE, Townsend MK, Grodstein F, Sperling RA, Rentz DM. Specific subjective memory complaints in older persons may indicate poor cognitive function. J Am Geriatr Soc. 2011 Sep; 59(9):1612-7. PMID: 21919893; PMCID: PMC3315361.
  229. Salloway S, Sperling R, Keren R, Porsteinsson AP, van Dyck CH, Tariot PN, Gilman S, Arnold D, Abushakra S, Hernandez C, Crans G, Liang E, Quinn G, Bairu M, Pastrak A, Cedarbaum JM. A phase 2 randomized trial of ELND005, scyllo-inositol, in mild to moderate Alzheimer disease. Neurology. 2011 Sep 27; 77(13):1253-62. PMID: 21917766; PMCID: PMC3179648.
  230. Reiman EM, McKhann GM, Albert MS, Sperling RA, Petersen RC, Blacker D. Alzheimer's disease: implications of the updated diagnostic and research criteria. J Clin Psychiatry. 2011 Sep; 72(9):1190-6. PMID: 21951985; PMCID: PMC4068242.
  231. Sabuncu MR, Desikan RS, Sepulcre J, Yeo BT, Liu H, Schmansky NJ, Reuter M, Weiner MW, Buckner RL, Sperling RA, Fischl B. The dynamics of cortical and hippocampal atrophy in Alzheimer disease. Arch Neurol. 2011 Aug; 68(8):1040-8. PMID: 21825241.
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  232. Marshall GA, Olson LE, Frey MT, Maye J, Becker JA, Rentz DM, Sperling RA, Johnson KA. Instrumental activities of daily living impairment is associated with increased amyloid burden. Dement Geriatr Cogn Disord. 2011; 31(6):443-50. PMID: 21778725.
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  233. Hedden T, Van Dijk KR, Shire EH, Sperling RA, Johnson KA, Buckner RL. Failure to modulate attentional control in advanced aging linked to white matter pathology. Cereb Cortex. 2012 May; 22(5):1038-51. PMID: 21765181; PMCID: PMC3328340.
  234. Jack CR, Barkhof F, Bernstein MA, Cantillon M, Cole PE, Decarli C, Dubois B, Duchesne S, Fox NC, Frisoni GB, Hampel H, Hill DL, Johnson K, Mangin JF, Scheltens P, Schwarz AJ, Sperling R, Suhy J, Thompson PM, Weiner M, Foster NL. Steps to standardization and validation of hippocampal volumetry as a biomarker in clinical trials and diagnostic criterion for Alzheimer's disease. Alzheimers Dement. 2011 Jul; 7(4):474-485.e4. PMID: 21784356; PMCID: PMC3396131.
  235. Sperling RA, Jack CR, Black SE, Frosch MP, Greenberg SM, Hyman BT, Scheltens P, Carrillo MC, Thies W, Bednar MM, Black RS, Brashear HR, Grundman M, Siemers ER, Feldman HH, Schindler RJ. Amyloid-related imaging abnormalities in amyloid-modifying therapeutic trials: recommendations from the Alzheimer's Association Research Roundtable Workgroup. Alzheimers Dement. 2011 Jul; 7(4):367-85. PMID: 21784348; PMCID: PMC3693547.
  236. Ewers M, Sperling RA, Klunk WE, Weiner MW, Hampel H. Neuroimaging markers for the prediction and early diagnosis of Alzheimer's disease dementia. Trends Neurosci. 2011 Aug; 34(8):430-42. PMID: 21696834; PMCID: PMC3275347.
  237. Rentz DM, Amariglio RE, Becker JA, Frey M, Olson LE, Frishe K, Carmasin J, Maye JE, Johnson KA, Sperling RA. Face-name associative memory performance is related to amyloid burden in normal elderly. Neuropsychologia. 2011 Jul; 49(9):2776-83. PMID: 21689670; PMCID: PMC3137730.
  238. Atri A, O'Brien JL, Sreenivasan A, Rastegar S, Salisbury S, DeLuca AN, O'Keefe KM, LaViolette PS, Rentz DM, Locascio JJ, Sperling RA. Test-retest reliability of memory task functional magnetic resonance imaging in Alzheimer disease clinical trials. Arch Neurol. 2011 May; 68(5):599-606. PMID: 21555634; PMCID: PMC3291175.
  239. Marshall GA, Rentz DM, Frey MT, Locascio JJ, Johnson KA, Sperling RA. Executive function and instrumental activities of daily living in mild cognitive impairment and Alzheimer's disease. Alzheimers Dement. 2011 May; 7(3):300-8. PMID: 21575871; PMCID: PMC3096844.
  240. Silverberg NB, Ryan LM, Carrillo MC, Sperling R, Petersen RC, Posner HB, Snyder PJ, Hilsabeck R, Gallagher M, Raber J, Rizzo A, Possin K, King J, Kaye J, Ott BR, Albert MS, Wagster MV, Schinka JA, Cullum CM, Farias ST, Balota D, Rao S, Loewenstein D, Budson AE, Brandt J, Manly JJ, Barnes L, Strutt A, Gollan TH, Ganguli M, Babcock D, Litvan I, Kramer JH, Ferman TJ. Assessment of cognition in early dementia. Alzheimers Dement. 2011 May 01; 7(3):e60-e76. PMID: 23559893.
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  241. Sperling RA, Aisen PS, Beckett LA, Bennett DA, Craft S, Fagan AM, Iwatsubo T, Jack CR, Kaye J, Montine TJ, Park DC, Reiman EM, Rowe CC, Siemers E, Stern Y, Yaffe K, Carrillo MC, Thies B, Morrison-Bogorad M, Wagster MV, Phelps CH. Toward defining the preclinical stages of Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease. Alzheimers Dement. 2011 May; 7(3):280-92. PMID: 21514248; PMCID: PMC3220946.
  242. Jack CR, Albert MS, Knopman DS, McKhann GM, Sperling RA, Carrillo MC, Thies B, Phelps CH. Introduction to the recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease. Alzheimers Dement. 2011 May; 7(3):257-62. PMID: 21514247.
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  243. Drzezga A, Becker JA, Van Dijk KR, Sreenivasan A, Talukdar T, Sullivan C, Schultz AP, Sepulcre J, Putcha D, Greve D, Johnson KA, Sperling RA. Neuronal dysfunction and disconnection of cortical hubs in non-demented subjects with elevated amyloid burden. Brain. 2011 Jun; 134(Pt 6):1635-46. PMID: 21490054.
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  244. Dickerson BC, Stoub TR, Shah RC, Sperling RA, Killiany RJ, Albert MS, Hyman BT, Blacker D, Detoledo-Morrell L. Alzheimer-signature MRI biomarker predicts AD dementia in cognitively normal adults. Neurology. 2011 Apr 19; 76(16):1395-402. PMID: 21490323.
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  245. Becker JA, Hedden T, Carmasin J, Maye J, Rentz DM, Putcha D, Fischl B, Greve DN, Marshall GA, Salloway S, Marks D, Buckner RL, Sperling RA, Johnson KA. Amyloid-ß associated cortical thinning in clinically normal elderly. Ann Neurol. 2011 Jun; 69(6):1032-42. PMID: 21437929; PMCID: PMC3117980.
  246. Pihlajamäki M, O'Keefe K, O'Brien J, Blacker D, Sperling RA. Failure of repetition suppression and memory encoding in aging and Alzheimer's disease. Brain Imaging Behav. 2011 Mar; 5(1):36-44. PMID: 21161449; PMCID: PMC3034137.
  247. Khachaturian ZS, Petersen RC, Snyder PJ, Khachaturian AS, Aisen P, de Leon M, Greenberg BD, Kukull W, Maruff P, Sperling RA, Stern Y, Touchon J, Vellas B, Andrieu S, Weiner MW, Carrillo MC, Bain LJ. Developing a global strategy to prevent Alzheimer's disease: Leon Thal Symposium 2010. Alzheimers Dement. 2011 Mar; 7(2):127-32. PMID: 21414553.
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  248. Vannini P, Hedden T, Becker JA, Sullivan C, Putcha D, Rentz D, Johnson KA, Sperling RA. Age and amyloid-related alterations in default network habituation to stimulus repetition. Neurobiol Aging. 2012 Jul; 33(7):1237-52. PMID: 21334099; PMCID: PMC3111876.
  249. Putcha D, O'Keefe K, LaViolette P, O'Brien J, Greve D, Rentz DM, Locascio J, Atri A, Sperling R. Reliability of functional magnetic resonance imaging associative encoding memory paradigms in non-demented elderly adults. Hum Brain Mapp. 2011 Dec; 32(12):2027-44. PMID: 21259385; PMCID: PMC3551453.
  250. Van Dijk KR, Sperling RA. Defaulting on the default network: increased risk for dementia. Neurology. 2011 Feb 08; 76(6):498-500. PMID: 21228298.
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  251. Bateman RJ, Aisen PS, De Strooper B, Fox NC, Lemere CA, Ringman JM, Salloway S, Sperling RA, Windisch M, Xiong C. Autosomal-dominant Alzheimer's disease: a review and proposal for the prevention of Alzheimer's disease. Alzheimers Res Ther. 2011 Jan 06; 3(1):1. PMID: 21211070; PMCID: PMC3109410.
  252. Yang W, Lui RL, Gao JH, Chan TF, Yau ST, Sperling RA, Huang X. Independent component analysis-based classification of Alzheimer's disease MRI data. J Alzheimers Dis. 2011; 24(4):775-83. PMID: 21321398; PMCID: PMC3697832.
  253. Desikan RS, Sabuncu MR, Schmansky NJ, Reuter M, Cabral HJ, Hess CP, Weiner MW, Biffi A, Anderson CD, Rosand J, Salat DH, Kemper TL, Dale AM, Sperling RA, Fischl B. Selective disruption of the cerebral neocortex in Alzheimer's disease. PLoS One. 2010 Sep 23; 5(9):e12853. PMID: 20886094.
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  254. Sperling R, Johnson K. Pro: Can biomarkers be gold standards in Alzheimer's disease? Alzheimers Res Ther. 2010 Jun 25; 2(3):17. PMID: 20587006; PMCID: PMC2919697.
  255. Laskowitz DT, Kolls BJ. A phase 2 multiple ascending dose trial of bapineuzumab in mild to moderate Alzheimer disease. Neurology. 2010 Jun 15; 74(24):2026; author reply 2026-7. PMID: 20548049.
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  257. O'Brien JL, O'Keefe KM, LaViolette PS, DeLuca AN, Blacker D, Dickerson BC, Sperling RA. Longitudinal fMRI in elderly reveals loss of hippocampal activation with clinical decline. Neurology. 2010 Jun 15; 74(24):1969-76. PMID: 20463288.
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  258. Vannini P, O'Brien J, O'Keefe K, Pihlajamäki M, Laviolette P, Sperling RA. What goes down must come up: role of the posteromedial cortices in encoding and retrieval. Cereb Cortex. 2011 Jan; 21(1):22-34. PMID: 20363808; PMCID: PMC3000562.
  259. Black RS, Sperling RA, Safirstein B, Motter RN, Pallay A, Nichols A, Grundman M. A single ascending dose study of bapineuzumab in patients with Alzheimer disease. Alzheimer Dis Assoc Disord. 2010 Apr-Jun; 24(2):198-203. PMID: 20505438; PMCID: PMC3715117.
  260. Wang L, Negreira A, LaViolette P, Bakkour A, Sperling RA, Dickerson BC. Intrinsic interhemispheric hippocampal functional connectivity predicts individual differences in memory performance ability. Hippocampus. 2010 Mar; 20(3):345-51. PMID: 20087893.
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  261. Rentz DM, Locascio JJ, Becker JA, Moran EK, Eng E, Buckner RL, Sperling RA, Johnson KA. Cognition, reserve, and amyloid deposition in normal aging. Ann Neurol. 2010 Mar; 67(3):353-64. PMID: 20373347.
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  262. Sperling RA, Dickerson BC, Pihlajamaki M, Vannini P, LaViolette PS, Vitolo OV, Hedden T, Becker JA, Rentz DM, Selkoe DJ, Johnson KA. Functional alterations in memory networks in early Alzheimer's disease. Neuromolecular Med. 2010 Mar; 12(1):27-43. PMID: 20069392.
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  263. Wang L, Laviolette P, O'Keefe K, Putcha D, Bakkour A, Van Dijk KR, Pihlajamäki M, Dickerson BC, Sperling RA. Intrinsic connectivity between the hippocampus and posteromedial cortex predicts memory performance in cognitively intact older individuals. Neuroimage. 2010 Jun; 51(2):910-7. PMID: 20188183; PMCID: PMC2856812.
  264. Pihlajamäki M, O' Keefe K, Bertram L, Tanzi RE, Dickerson BC, Blacker D, Albert MS, Sperling RA. Evidence of altered posteromedial cortical FMRI activity in subjects at risk for Alzheimer disease. Alzheimer Dis Assoc Disord. 2010 Jan-Mar; 24(1):28-36. PMID: 19571734.
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  265. Salloway S, Sperling R, Gilman S, Fox NC, Blennow K, Raskind M, Sabbagh M, Honig LS, Doody R, van Dyck CH, Mulnard R, Barakos J, Gregg KM, Liu E, Lieberburg I, Schenk D, Black R, Grundman M. A phase 2 multiple ascending dose trial of bapineuzumab in mild to moderate Alzheimer disease. Neurology. 2009 Dec 15; 73(24):2061-70. PMID: 19923550; PMCID: PMC2790221.
  266. Hedden T, Van Dijk KR, Becker JA, Mehta A, Sperling RA, Johnson KA, Buckner RL. Disruption of functional connectivity in clinically normal older adults harboring amyloid burden. J Neurosci. 2009 Oct 07; 29(40):12686-94. PMID: 19812343; PMCID: PMC2808119.
  267. Chua EF, Schacter DL, Sperling RA. Neural correlates of metamemory: a comparison of feeling-of-knowing and retrospective confidence judgments. J Cogn Neurosci. 2009 Sep; 21(9):1751-65. PMID: 18823230; PMCID: PMC2709699.
  268. Sperling RA, Laviolette PS, O'Keefe K, O'Brien J, Rentz DM, Pihlajamaki M, Marshall G, Hyman BT, Selkoe DJ, Hedden T, Buckner RL, Becker JA, Johnson KA. Amyloid deposition is associated with impaired default network function in older persons without dementia. Neuron. 2009 Jul 30; 63(2):178-88. PMID: 19640477; PMCID: PMC2738994.
  269. Chua EF, Schacter DL, Sperling RA. Neural basis for recognition confidence in younger and older adults. Psychol Aging. 2009 Mar; 24(1):139-53. PMID: 19290745; PMCID: PMC2657923.
  270. Carrillo MC, Blackwell A, Hampel H, Lindborg J, Sperling R, Schenk D, Sevigny JJ, Ferris S, Bennett DA, Craft S, Hsu T, Klunk W. Early risk assessment for Alzheimer's disease. Alzheimers Dement. 2009 Mar; 5(2):182-96. PMID: 19328456.
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  271. Buckner RL, Sepulcre J, Talukdar T, Krienen FM, Liu H, Hedden T, Andrews-Hanna JR, Sperling RA, Johnson KA. Cortical hubs revealed by intrinsic functional connectivity: mapping, assessment of stability, and relation to Alzheimer's disease. J Neurosci. 2009 Feb 11; 29(6):1860-73. PMID: 19211893; PMCID: PMC2750039.
  272. Dickerson BC, Sperling RA. Large-scale functional brain network abnormalities in Alzheimer's disease: insights from functional neuroimaging. Behav Neurol. 2009; 21(1):63-75. PMID: 19847046; PMCID: PMC2872923.
  273. Pihlajamäki M, Sperling RA. Functional MRI assessment of task-induced deactivation of the default mode network in Alzheimer's disease and at-risk older individuals. Behav Neurol. 2009; 21(1):77-91. PMID: 19847047.
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  274. Dickerson BC, Bakkour A, Salat DH, Feczko E, Pacheco J, Greve DN, Grodstein F, Wright CI, Blacker D, Rosas HD, Sperling RA, Atri A, Growdon JH, Hyman BT, Morris JC, Fischl B, Buckner RL. The cortical signature of Alzheimer's disease: regionally specific cortical thinning relates to symptom severity in very mild to mild AD dementia and is detectable in asymptomatic amyloid-positive individuals. Cereb Cortex. 2009 Mar; 19(3):497-510. PMID: 18632739; PMCID: PMC2638813.
  275. Pihlajamäki M, DePeau KM, Blacker D, Sperling RA. Impaired medial temporal repetition suppression is related to failure of parietal deactivation in Alzheimer disease. Am J Geriatr Psychiatry. 2008 Apr; 16(4):283-92. PMID: 18378553; PMCID: PMC2602949.
  276. Miller SL, Celone K, DePeau K, Diamond E, Dickerson BC, Rentz D, Pihlajamäki M, Sperling RA. Age-related memory impairment associated with loss of parietal deactivation but preserved hippocampal activation. Proc Natl Acad Sci U S A. 2008 Feb 12; 105(6):2181-6. PMID: 18238903; PMCID: PMC2538895.
  277. Dickerson BC, Sperling RA. Functional abnormalities of the medial temporal lobe memory system in mild cognitive impairment and Alzheimer's disease: insights from functional MRI studies. Neuropsychologia. 2008; 46(6):1624-35. PMID: 18206188; PMCID: PMC2760288.
  278. Dickerson BC, Sperling RA, Hyman BT, Albert MS, Blacker D. Clinical prediction of Alzheimer disease dementia across the spectrum of mild cognitive impairment. Arch Gen Psychiatry. 2007 Dec; 64(12):1443-50. PMID: 18056553; PMCID: PMC2581771.
  279. Diamond EL, Miller S, Dickerson BC, Atri A, DePeau K, Fenstermacher E, Pihlajamäki M, Celone K, Salisbury S, Gregas M, Rentz D, Sperling RA. Relationship of fMRI activation to clinical trial memory measures in Alzheimer disease. Neurology. 2007 Sep 25; 69(13):1331-41. PMID: 17893294.
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  280. Miller SL, Fenstermacher E, Bates J, Blacker D, Sperling RA, Dickerson BC. Hippocampal activation in adults with mild cognitive impairment predicts subsequent cognitive decline. J Neurol Neurosurg Psychiatry. 2008 Jun; 79(6):630-5. PMID: 17846109; PMCID: PMC2683145.
  281. Rentz DM, Huh TJ, Sardinha LM, Moran EK, Becker JA, Daffner KR, Sperling RA, Johnson KA. Intelligence quotient-adjusted memory impairment is associated with abnormal single photon emission computed tomography perfusion. J Int Neuropsychol Soc. 2007 Sep; 13(5):821-31. PMID: 17697413.
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  282. Glanz BI, Holland CM, Gauthier SA, Amunwa EL, Liptak Z, Houtchens MK, Sperling RA, Khoury SJ, Guttmann CR, Weiner HL. Cognitive dysfunction in patients with clinically isolated syndromes or newly diagnosed multiple sclerosis. Mult Scler. 2007 Sep; 13(8):1004-10. PMID: 17623735.
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  283. Chappell AS, Gonzales C, Williams J, Witte MM, Mohs RC, Sperling R. AMPA potentiator treatment of cognitive deficits in Alzheimer disease. Neurology. 2007 Mar 27; 68(13):1008-12. PMID: 17389305.
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  284. Sperling R. Functional MRI studies of associative encoding in normal aging, mild cognitive impairment, and Alzheimer's disease. Ann N Y Acad Sci. 2007 Feb; 1097:146-55. PMID: 17413017.
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  285. Dickerson BC, Miller SL, Greve DN, Dale AM, Albert MS, Schacter DL, Sperling RA. Prefrontal-hippocampal-fusiform activity during encoding predicts intraindividual differences in free recall ability: an event-related functional-anatomic MRI study. Hippocampus. 2007; 17(11):1060-70. PMID: 17604356; PMCID: PMC2739881.
  286. Chua EF, Schacter DL, Rand-Giovannetti E, Sperling RA. Evidence for a specific role of the anterior hippocampal region in successful associative encoding. Hippocampus. 2007; 17(11):1071-80. PMID: 17604351.
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  287. Pellegrino T, Sperling RA, Alivisatos AP, Parak WJ. Gel electrophoresis of gold-DNA nanoconjugates. J Biomed Biotechnol. 2007; 2007:26796. PMID: 18401452; PMCID: PMC2288681.
  288. Rentz DM, Sardinha LM, Huh TJ, Searl MM, Daffner KR, Sperling RA. IQ-based norms for highly intelligent adults. Clin Neuropsychol. 2006 Dec; 20(4):637-48. PMID: 16980251.
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  289. Alsop DC, Fearing MA, Johnson K, Sperling R, Fong TG, Inouye SK. The role of neuroimaging in elucidating delirium pathophysiology. J Gerontol A Biol Sci Med Sci. 2006 Dec; 61(12):1287-93. PMID: 17234822.
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  290. Celone KA, Calhoun VD, Dickerson BC, Atri A, Chua EF, Miller SL, DePeau K, Rentz DM, Selkoe DJ, Blacker D, Albert MS, Sperling RA. Alterations in memory networks in mild cognitive impairment and Alzheimer's disease: an independent component analysis. J Neurosci. 2006 Oct 04; 26(40):10222-31. PMID: 17021177.
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  291. Salmon DP, Cummings JL, Jin S, Sano M, Sperling RA, Zamrini E, Petersen RC, Edland SD, Thal LJ, Ferris SH. ADCS Prevention Instrument Project: development of a brief verbal memory test for primary prevention clinical trials. Alzheimer Dis Assoc Disord. 2006 Oct-Dec; 20(4 Suppl 3):S139-46. PMID: 17135807.
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  292. Chua EF, Schacter DL, Rand-Giovannetti E, Sperling RA. Understanding metamemory: neural correlates of the cognitive process and subjective level of confidence in recognition memory. Neuroimage. 2006 Feb 15; 29(4):1150-60. PMID: 16303318.
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  293. Dickerson BC, Salat DH, Greve DN, Chua EF, Rand-Giovannetti E, Rentz DM, Bertram L, Mullin K, Tanzi RE, Blacker D, Albert MS, Sperling RA. Increased hippocampal activation in mild cognitive impairment compared to normal aging and AD. Neurology. 2005 Aug 09; 65(3):404-11. PMID: 16087905; PMCID: PMC4335677.
  294. Dickerson BC, Sperling RA. Neuroimaging biomarkers for clinical trials of disease-modifying therapies in Alzheimer's disease. NeuroRx. 2005 Apr; 2(2):348-60. PMID: 15897955.
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  295. Rand-Giovannetti E, Chua EF, Driscoll AE, Schacter DL, Albert MS, Sperling RA. Hippocampal and neocortical activation during repetitive encoding in older persons. Neurobiol Aging. 2006 Jan; 27(1):173-82. PMID: 16298252.
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  296. Chua EF, Rand-Giovannetti E, Schacter DL, Albert MS, Sperling RA. Dissociating confidence and accuracy: functional magnetic resonance imaging shows origins of the subjective memory experience. J Cogn Neurosci. 2004 Sep; 16(7):1131-42. PMID: 15453969.
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  297. Dickerson BC, Salat DH, Bates JF, Atiya M, Killiany RJ, Greve DN, Dale AM, Stern CE, Blacker D, Albert MS, Sperling RA. Medial temporal lobe function and structure in mild cognitive impairment. Ann Neurol. 2004 Jul; 56(1):27-35. PMID: 15236399; PMCID: PMC4335689.
  298. Lange N, Lake S, Sperling R, Brown J, Routledge C, Albert M, Heckers S. Two macroscopic and microscopic brain imaging studies of human hippocampus in early Alzheimer's disease and schizophrenia research. Stat Med. 2004 Jan 30; 23(2):327-50. PMID: 14716733.
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  299. Rentz DM, Huh TJ, Faust RR, Budson AE, Scinto LF, Sperling RA, Daffner KR. Use of IQ-adjusted norms to predict progressive cognitive decline in highly intelligent older individuals. Neuropsychology. 2004 Jan; 18(1):38-49. PMID: 14744186.
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  300. Sperling R, Chua E, Cocchiarella A, Rand-Giovannetti E, Poldrack R, Schacter DL, Albert M. Putting names to faces: successful encoding of associative memories activates the anterior hippocampal formation. Neuroimage. 2003 Oct; 20(2):1400-10. PMID: 14568509; PMCID: PMC3230827.
  301. Monsonego A, Zota V, Karni A, Krieger JI, Bar-Or A, Bitan G, Budson AE, Sperling R, Selkoe DJ, Weiner HL. Increased T cell reactivity to amyloid beta protein in older humans and patients with Alzheimer disease. J Clin Invest. 2003 Aug; 112(3):415-22. PMID: 12897209; PMCID: PMC166296.
  302. Sperling RA, Bates JF, Chua EF, Cocchiarella AJ, Rentz DM, Rosen BR, Schacter DL, Albert MS. fMRI studies of associative encoding in young and elderly controls and mild Alzheimer's disease. J Neurol Neurosurg Psychiatry. 2003 Jan; 74(1):44-50. PMID: 12486265; PMCID: PMC1738201.
  303. Sperling R, Schnabel M, Sauerwein B, Von Garrel T, Gotzen L, Stiletto R. [Evaluation and results of the gliding nail in the elderly patient]. Zentralbl Chir. 2002 Jun; 127(6):507-13. PMID: 12094276.
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  304. Budson AE, Michalska KJ, Rentz DM, Joubert CC, Daffner KR, Schacter DL, Sperling RA. Use of a false recognition paradigm in an Alzheimer's disease clinical trial: a pilot study. Am J Alzheimers Dis Other Demen. 2002 Mar-Apr; 17(2):93-100. PMID: 11954675.
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  305. Sperling R, Greve D, Dale A, Killiany R, Holmes J, Rosas HD, Cocchiarella A, Firth P, Rosen B, Lake S, Lange N, Routledge C, Albert M. Functional MRI detection of pharmacologically induced memory impairment. Proc Natl Acad Sci U S A. 2002 Jan 08; 99(1):455-60. PMID: 11756667; PMCID: PMC117581.
  306. Sperling RA, Bates JF, Cocchiarella AJ, Schacter DL, Rosen BR, Albert MS. Encoding novel face-name associations: a functional MRI study. Hum Brain Mapp. 2001 Nov; 14(3):129-39. PMID: 11559958.
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  307. Sperling R. The volumes of memory. J Neurol Neurosurg Psychiatry. 2001 Jul; 71(1):5. PMID: 11413252; PMCID: PMC1737461.
  308. Johnson KA, Lopera F, Jones K, Becker A, Sperling R, Hilson J, Londono J, Siegert I, Arcos M, Moreno S, Madrigal L, Ossa J, Pineda N, Ardila A, Roselli M, Albert MS, Kosik KS, Rios A. Presenilin-1-associated abnormalities in regional cerebral perfusion. Neurology. 2001 Jun 12; 56(11):1545-51. PMID: 11402113.
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  309. Sperling RA, Guttmann CR, Hohol MJ, Warfield SK, Jakab M, Parente M, Diamond EL, Daffner KR, Olek MJ, Orav EJ, Kikinis R, Jolesz FA, Weiner HL. Regional magnetic resonance imaging lesion burden and cognitive function in multiple sclerosis: a longitudinal study. Arch Neurol. 2001 Jan; 58(1):115-21. PMID: 11176944.
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  310. Saag K, van der Heijde D, Fisher C, Samara A, DeTora L, Bolognese J, Sperling R, Daniels B. Rofecoxib, a new cyclooxygenase 2 inhibitor, shows sustained efficacy, comparable with other nonsteroidal anti-inflammatory drugs: a 6-week and a 1-year trial in patients with osteoarthritis. Osteoarthritis Studies Group. Arch Fam Med. 2000 Nov-Dec; 9(10):1124-34. PMID: 11115219.
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  311. Irwin KL, Moorman AC, O'Sullivan MJ, Sperling R, Koestler ME, Soto I, Rice R, Brodman M, Yasin S, Droese A, Zhang D, Schwartz DA, Byers RH. Influence of human immunodeficiency virus infection on pelvic inflammatory disease. Obstet Gynecol. 2000 Apr; 95(4):525-34. PMID: 10725484.
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  312. Greenberg SM, Tennis MK, Brown LB, Gomez-Isla T, Hayden DL, Schoenfeld DA, Walsh KL, Corwin C, Daffner KR, Friedman P, Meadows ME, Sperling RA, Growdon JH. Donepezil therapy in clinical practice: a randomized crossover study. Arch Neurol. 2000 Jan; 57(1):94-9. PMID: 10634454.
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  313. Pitt J, Schluchter M, Jenson H, Kovacs A, LaRussa P, McIntosh K, Boyer P, Cooper E, Goldfarb J, Hammill H, Hodes D, Peavy H, Sperling R, Tuomala R, Shearer W. Maternal and perinatal factors related to maternal-infant transmission of HIV-1 in the P2C2 HIV study: the role of EBV shedding. Pediatric Pulmonary and Cardiovascular Complications of Vertically Transmitted HIV-1 Infection (P2C2 HIV) Study Group. J Acquir Immune Defic Syndr Hum Retrovirol. 1998 Dec 15; 19(5):462-70. PMID: 9859959.
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  314. Sperling R. Zidovudine. Infect Dis Obstet Gynecol. 1998; 6(5):197-203. PMID: 9894173; PMCID: PMC1784811.
  315. Martin R, Boyer P, Hammill H, Peavy H, Platzker A, Settlage R, Shah A, Sperling R, Tuomala R, Wu M. Incidence of premature birth and neonatal respiratory disease in infants of HIV-positive mothers. The Pediatric Pulmonary and Cardiovascular Complications of Vertically Transmitted Human Immunodeficiency Virus Infection Study Group. J Pediatr. 1997 Dec; 131(6):851-6. PMID: 9427889.
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  316. Feske SK, Sperling RA, Schwartz RB. Extensive reversible brain magnetic resonance lesions in a patient with HELLP syndrome. J Neuroimaging. 1997 Oct; 7(4):247-50. PMID: 9344010.
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  317. Sandson TA, O'Connor M, Sperling RA, Edelman RR, Warach S. Noninvasive perfusion MRI in Alzheimer's disease: a preliminary report. Neurology. 1996 Nov; 47(5):1339-42. PMID: 8909457.
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  318. Hsuih TC, Park YN, Zaretsky C, Wu F, Tyagi S, Kramer FR, Sperling R, Zhang DY. Novel, ligation-dependent PCR assay for detection of hepatitis C in serum. J Clin Microbiol. 1996 Mar; 34(3):501-7. PMID: 8904402; PMCID: PMC228834.
  319. Jennings TS, Dottino P, Sperling R, Beddoe AM. Screening for human immunodeficiency virus in inner city females with abnormal cervical cytology. Infect Dis Obstet Gynecol. 1996; 4(5):281-6. PMID: 18476108; PMCID: PMC2364508.
  320. Sandson TA, Sperling RA, Price BH. Alzheimer's disease: an update. Compr Ther. 1995 Sep; 21(9):480-5. PMID: 8565434.
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  321. Rollinson D, Brodman ML, Friedman F, Sperling R. Transvaginal small-bowel evisceration: a case report. Mt Sinai J Med. 1995 May; 62(3):235-8. PMID: 7616980.
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  322. Kanter DS, Horensky D, Sperling RA, Kaplan JD, Malachowski ME, Churchill WH. Plasmapheresis in fulminant acute disseminated encephalomyelitis. Neurology. 1995 Apr; 45(4):824-7. PMID: 7723979.
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  323. Drazen JM, Lilly CM, Sperling R, Rubin P, Israel E. Role of cysteinyl leukotrienes in spontaneous asthmatic responses. Adv Prostaglandin Thromboxane Leukot Res. 1994; 22:251-62. PMID: 7771339.
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  324. Dottino PR, Sperling R, Kee R. Screening for human immunodeficiency virus and sexually transmitted diseases in an inner-city colposcopy clinic. Mt Sinai J Med. 1993 Sep; 60(4):327-9. PMID: 8232380.
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  325. Brodman M, Port M, Friedman F, Sperling R, Dottino P, Thomas AG. Operating room personnel morbidity from carbon dioxide laser use during preceptored surgery. Obstet Gynecol. 1993 Apr; 81(4):607-9. PMID: 8459977.
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  326. Weinblatt ME, Kremer JM, Coblyn JS, Helfgott S, Maier AL, Petrillo G, Henson B, Rubin P, Sperling R. Zileuton, a 5-lipoxygenase inhibitor in rheumatoid arthritis. J Rheumatol. 1992 Oct; 19(10):1537-41. PMID: 1334515.
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  327. Johnson KA, Sperling RA, Holman BL, Nagel JS, Growdon JH. Cerebral perfusion in progressive supranuclear palsy. J Nucl Med. 1992 May; 33(5):704-9. PMID: 1569479.
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  328. Brodman M, Dottino P, Friedman F, Heller D, Bleiweiss I, Sperling R. Human papillomavirus-associated lesions of the vagina and cervix. Treatment with a laser and topical 5-fluorouracil. J Reprod Med. 1992 May; 37(5):453-6. PMID: 1324311.
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  329. Weinblatt M, Helfgott S, Coblyn J, Spragg J, Uedelhoven WM, Tumeh S, Sperling R, Lorenz R, Maier A, Weber P. The effects of cyclosporin A on eicosanoid excretion in patients with rheumatoid arthritis. Arthritis Rheum. 1991 Apr; 34(4):481-5. PMID: 2012627.
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  330. Berrier J, Sperling R, Preisinger J, Evans V, Mason J, Walther V. HIV/AIDS education in a prenatal clinic: an assessment. AIDS Educ Prev. 1991; 3(2):100-17. PMID: 1873134.
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  331. Mason J, Preisinger J, Sperling R, Walther V, Berrier J, Evans V. Incorporating HIV education and counseling into routine prenatal care: a program model. AIDS Educ Prev. 1991; 3(2):118-23. PMID: 1873135.
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  332. Israel E, Dermarkarian R, Rosenberg M, Sperling R, Taylor G, Rubin P, Drazen JM. The effects of a 5-lipoxygenase inhibitor on asthma induced by cold, dry air. N Engl J Med. 1990 Dec 20; 323(25):1740-4. PMID: 2247106.
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  333. Arad-Dann H, Isenberg D, Ovadia E, Shoenfeld Y, Sperling J, Sperling R. Autoantibodies against a nuclear 56 kDa protein: a marker for inflammatory muscle disease. J Autoimmun. 1989 Dec; 2(6):877-88. PMID: 2619871.
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  334. Sperling R, Havron A, Sperling J. Photochemical cross-linking between proteins and nucleic acids as a probe of nucleoprotein interactions. Ann N Y Acad Sci. 1980; 346:386-8. PMID: 6930188.
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  335. Schumer W, Sperling R. Shock and its effect on the cell. JAMA. 1968 Jul 22; 205(4):215-9. PMID: 5694918.
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