Harvard Catalyst Profiles

Contact, publication, and social network information about Harvard faculty and fellows.

Lee Marshall Nadler, M.D.

Co-Author

This page shows the publications co-authored by Lee Nadler and Gordon Freeman.
Connection Strength

2.441
  1. The BB1 monoclonal antibody recognizes both cell surface CD74 (MHC class II-associated invariant chain) as well as B7-1 (CD80), resolving the question regarding a third CD28/CTLA-4 counterreceptor. J Immunol. 1998 Sep 15; 161(6):2708-15.
    View in: PubMed
    Score: 0.200
  2. B7-1 and B7-2 do not deliver identical costimulatory signals, since B7-2 but not B7-1 preferentially costimulates the initial production of IL-4. Immunity. 1995 May; 2(5):523-32.
    View in: PubMed
    Score: 0.158
  3. Cloning of B7-2: a CTLA-4 counter-receptor that costimulates human T cell proliferation. Science. 1993 Nov 05; 262(5135):909-11.
    View in: PubMed
    Score: 0.143
  4. The gene for B7, a costimulatory signal for T-cell activation, maps to chromosomal region 3q13.3-3q21. Blood. 1992 Jan 15; 79(2):489-94.
    View in: PubMed
    Score: 0.126
  5. Structure, expression, and T cell costimulatory activity of the murine homologue of the human B lymphocyte activation antigen B7. J Exp Med. 1991 Sep 01; 174(3):625-31.
    View in: PubMed
    Score: 0.123
  6. B7, a new member of the Ig superfamily with unique expression on activated and neoplastic B cells. J Immunol. 1989 Oct 15; 143(8):2714-22.
    View in: PubMed
    Score: 0.108
  7. Interleukin 6 gene expression in normal and neoplastic B cells. J Clin Invest. 1989 May; 83(5):1512-8.
    View in: PubMed
    Score: 0.104
  8. Engagement of CD83 ligand induces prolonged expansion of CD8+ T cells and preferential enrichment for antigen specificity. Blood. 2006 Feb 15; 107(4):1528-36.
    View in: PubMed
    Score: 0.082
  9. p27kip1 functions as an anergy factor inhibiting interleukin 2 transcription and clonal expansion of alloreactive human and mouse helper T lymphocytes. Nat Med. 2000 Mar; 6(3):290-7.
    View in: PubMed
    Score: 0.055
  10. Cloning of BY55, a novel Ig superfamily member expressed on NK cells, CTL, and intestinal intraepithelial lymphocytes. J Immunol. 1998 Sep 15; 161(6):2780-90.
    View in: PubMed
    Score: 0.050
  11. The leukocyte semaphorin CD100 is expressed in most T-cell, but few B-cell, non-Hodgkin's lymphomas. Am J Pathol. 1998 Jul; 153(1):255-62.
    View in: PubMed
    Score: 0.049
  12. In vivo expression of B7-1 and B7-2 by follicular lymphoma cells can prevent induction of T-cell anergy but is insufficient to induce significant T-cell proliferation. Blood. 1997 Dec 01; 90(11):4297-306.
    View in: PubMed
    Score: 0.047
  13. Maintenance of human T cell anergy: blocking of IL-2 gene transcription by activated Rap1. Science. 1997 Oct 03; 278(5335):124-8.
    View in: PubMed
    Score: 0.047
  14. Induction of T cell clonal anergy results in resistance, whereas CD28-mediated costimulation primes for susceptibility to Fas- and Bax-mediated programmed cell death. J Immunol. 1997 Oct 01; 159(7):3156-67.
    View in: PubMed
    Score: 0.047
  15. Ex vivo generation of human anti-pre-B leukemia-specific autologous cytolytic T cells. Blood. 1997 Jul 15; 90(2):549-61.
    View in: PubMed
    Score: 0.046
  16. Breast cancer-associated antigen, DF3/MUC1, induces apoptosis of activated human T cells. Nat Med. 1996 Dec; 2(12):1367-70.
    View in: PubMed
    Score: 0.044
  17. Human CD100, a novel leukocyte semaphorin that promotes B-cell aggregation and differentiation. Proc Natl Acad Sci U S A. 1996 Oct 15; 93(21):11780-5.
    View in: PubMed
    Score: 0.044
  18. The role of B7-1/B7-2:CD28/CLTA-4 pathways in the prevention of anergy, induction of productive immunity and down-regulation of the immune response. Immunol Rev. 1996 Oct; 153:5-26.
    View in: PubMed
    Score: 0.044
  19. Differential association of protein tyrosine kinases with the T cell receptor is linked to the induction of anergy and its prevention by B7 family-mediated costimulation. J Exp Med. 1996 Aug 01; 184(2):365-76.
    View in: PubMed
    Score: 0.043
  20. Pre-B acute lymphoblastic leukemia cells may induce T-cell anergy to alloantigen. Blood. 1996 Jul 01; 88(1):41-8.
    View in: PubMed
    Score: 0.043
  21. Complete blockade of B7 family-mediated costimulation is necessary to induce human alloantigen-specific anergy: a method to ameliorate graft-versus-host disease and extend the donor pool. Blood. 1996 Jun 01; 87(11):4887-93.
    View in: PubMed
    Score: 0.043
  22. Follicular lymphomas can be induced to present alloantigen efficiently: a conceptual model to improve their tumor immunogenicity. Proc Natl Acad Sci U S A. 1995 Aug 29; 92(18):8200-4.
    View in: PubMed
    Score: 0.040
  23. The critical role of CD28 signalling in the prevention of human T-cell anergy. Res Immunol. 1995 Mar-Apr; 146(3):140-9.
    View in: PubMed
    Score: 0.039
  24. Pivotal role of the B7:CD28 pathway in transplantation tolerance and tumor immunity. Blood. 1994 Nov 15; 84(10):3261-82.
    View in: PubMed
    Score: 0.038
  25. Prevention of T cell anergy by signaling through the gamma c chain of the IL-2 receptor. Science. 1994 Nov 11; 266(5187):1039-42.
    View in: PubMed
    Score: 0.038
  26. CD2 is involved in maintenance and reversal of human alloantigen-specific clonal anergy. J Exp Med. 1994 Nov 01; 180(5):1665-73.
    View in: PubMed
    Score: 0.038
  27. Blockade of the CD28 co-stimulatory pathway: a means to induce tolerance. Curr Opin Immunol. 1994 Oct; 6(5):797-807.
    View in: PubMed
    Score: 0.038
  28. Activated human B lymphocytes express three CTLA-4 counterreceptors that costimulate T-cell activation. Proc Natl Acad Sci U S A. 1993 Dec 01; 90(23):11059-63.
    View in: PubMed
    Score: 0.036
  29. [Failing B7 costimulation engenders a peripheral clonal T-cell anergy in a human antigen-specific model]. Schweiz Med Wochenschr. 1993 Nov 27; 123(47):2255-6.
    View in: PubMed
    Score: 0.036
  30. B7 but not intercellular adhesion molecule-1 costimulation prevents the induction of human alloantigen-specific tolerance. J Exp Med. 1993 Nov 01; 178(5):1753-63.
    View in: PubMed
    Score: 0.036
  31. Human T-cell clonal anergy is induced by antigen presentation in the absence of B7 costimulation. Proc Natl Acad Sci U S A. 1993 Jul 15; 90(14):6586-90.
    View in: PubMed
    Score: 0.035
  32. Murine B7 antigen provides an efficient costimulatory signal for activation of murine T lymphocytes via the T-cell receptor/CD3 complex. Proc Natl Acad Sci U S A. 1992 Jan 01; 89(1):271-5.
    View in: PubMed
    Score: 0.031
  33. All advanced stage non-Hodgkin's lymphomas with a polymerase chain reaction amplifiable breakpoint of bcl-2 have residual cells containing the bcl-2 rearrangement at evaluation and after treatment. Blood. 1991 Dec 15; 78(12):3275-80.
    View in: PubMed
    Score: 0.031
  34. Selective induction of B7/BB-1 on interferon-gamma stimulated monocytes: a potential mechanism for amplification of T cell activation through the CD28 pathway. Cell Immunol. 1991 Oct 15; 137(2):429-37.
    View in: PubMed
    Score: 0.031
  35. B-cell surface antigen B7 provides a costimulatory signal that induces T cells to proliferate and secrete interleukin 2. Proc Natl Acad Sci U S A. 1991 Aug 01; 88(15):6575-9.
    View in: PubMed
    Score: 0.031
  36. Follicular dendritic cells contain a unique gene repertoire demonstrated by single-cell polymerase chain reaction. Blood. 1991 Feb 15; 77(4):787-91.
    View in: PubMed
    Score: 0.030
  37. Activation primes human B lymphocytes to respond to heat shock. J Exp Med. 1989 Nov 01; 170(5):1763-8.
    View in: PubMed
    Score: 0.027
  38. Isolated human follicular dendritic cells display a unique antigenic phenotype. J Exp Med. 1989 Jun 01; 169(6):2043-58.
    View in: PubMed
    Score: 0.026
  39. Expression and regulation of CD5 on in vitro activated human B cells. Eur J Immunol. 1989 May; 19(5):849-55.
    View in: PubMed
    Score: 0.026
  40. Studies of in vitro activated CD5+ B cells. Blood. 1989 Jan; 73(1):202-8.
    View in: PubMed
    Score: 0.026
  41. Pre-exposure of human B cells to recombinant IL-1 enhances subsequent proliferation. J Immunol. 1988 Nov 15; 141(10):3398-404.
    View in: PubMed
    Score: 0.025
  42. B7, a B-cell-restricted antigen that identifies preactivated B cells. J Immunol. 1987 Nov 15; 139(10):3260-7.
    View in: PubMed
    Score: 0.024
  43. Tob is a negative regulator of activation that is expressed in anergic and quiescent T cells. Nat Immunol. 2001 Dec; 2(12):1174-82.
    View in: PubMed
    Score: 0.016
  44. Expression of MHC class II-associated invariant chain (Ii;CD74) in thymic epithelial neoplasms. Appl Immunohistochem Mol Morphol. 2000 Sep; 8(3):210-5.
    View in: PubMed
    Score: 0.014
  45. A cell type-specific enhancer in the human B7.1 gene regulated by NF-kappaB. J Exp Med. 1996 Mar 01; 183(3):777-89.
    View in: PubMed
    Score: 0.010
  46. B7-1 is superior to B7-2 costimulation in the induction and maintenance of T cell-mediated antileukemia immunity. Further evidence that B7-1 and B7-2 are functionally distinct. J Immunol. 1996 Feb 01; 156(3):1126-31.
    View in: PubMed
    Score: 0.010
  47. Differential expression of alternate mB7-2 transcripts. J Immunol. 1995 Dec 15; 155(12):5490-7.
    View in: PubMed
    Score: 0.010
  48. Role of B7-1 in mediating an immune response to myeloid leukemia cells. Blood. 1995 May 01; 85(9):2507-15.
    View in: PubMed
    Score: 0.010
  49. Characterization of the murine B7-1 genomic locus reveals an additional exon encoding an alternative cytoplasmic domain and a chromosomal location of chromosome 16, band B5. J Immunol. 1994 Dec 01; 153(11):5038-48.
    View in: PubMed
    Score: 0.010
  50. Effects of cyclosporin A, FK 506, and mycalamide A on the activation of murine CD4+ T cells by the murine B7 antigen. Eur J Immunol. 1993 Jan; 23(1):283-6.
    View in: PubMed
    Score: 0.008
  51. Murine B7 antigen provides a sufficient costimulatory signal for antigen-specific and MHC-restricted T cell activation. J Immunol. 1992 Dec 15; 149(12):3802-8.
    View in: PubMed
    Score: 0.008
  52. Early signaling defects in human T cells anergized by T cell presentation of autoantigen. J Exp Med. 1992 Jul 01; 176(1):177-86.
    View in: PubMed
    Score: 0.008
  53. Expression and function of the murine B7 antigen, the major costimulatory molecule expressed by peritoneal exudate cells. Proc Natl Acad Sci U S A. 1992 May 01; 89(9):4210-4.
    View in: PubMed
    Score: 0.008
Connection Strength
The connection strength for co-authors is the sum of the scores for each of their shared publications.

Publication scores are based on many factors, including how long ago they were written and whether the person is a first or senior author.
Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.