Harvard Catalyst Profiles

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Joshua Tycko

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Biography
education and training
StanfordPhD08/2022Genetics

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selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Cabrera A, Edelstein HI, Glykofrydis F, Love KS, Palacios S, Tycko J, Zhang M, Lensch S, Shields CE, Livingston M, Weiss R, Zhao H, Haynes KA, Morsut L, Chen YY, Khalil AS, Wong WW, Collins JJ, Rosser SJ, Polizzi K, Elowitz MB, Fussenegger M, Hilton IB, Leonard JN, Bintu L, Galloway KE, Deans TL. The sound of silence: Transgene silencing in mammalian cell engineering. Cell Syst. 2022 12 21; 13(12):950-973. PMID: 36549273; PMCID: PMC9880859.
    Citations: 1     Fields:    Translation:Animals
  2. Durrant MG, Fanton A, Tycko J, Hinks M, Chandrasekaran SS, Perry NT, Schaepe J, Du PP, Lotfy P, Bassik MC, Bintu L, Bhatt AS, Hsu PD. Systematic discovery of recombinases for efficient integration of large DNA sequences into the human genome. Nat Biotechnol. 2022 Oct 10. PMID: 36217031.
    Citations: 4     Fields:    
  3. Tycko J, Adam VS, Crosariol M, Ohlstein J, Sanmiguel J, Tretiakova AP, Roy S, Worgall S, Wilson JM, Limberis MP. Adeno-Associated Virus Vector-Mediated Expression of Antirespiratory Syncytial Virus Antibody Prevents Infection in Mouse Airways. Hum Gene Ther. 2021 12; 32(23-24):1450-1456. PMID: 34415793.
    Citations: 2     Fields:    Translation:AnimalsCells
  4. Tycko J, DelRosso N, Hess GT, Banerjee A, Mukund A, Van MV, Ego BK, Yao D, Spees K, Suzuki P, Marinov GK, Kundaje A, Bassik MC, Bintu L. High-Throughput Discovery and Characterization of Human Transcriptional Effectors. Cell. 2020 12 23; 183(7):2020-2035.e16. PMID: 33326746.
    Citations: 16     Fields:    Translation:HumansCells
  5. Tycko J, Wainberg M, Marinov GK, Ursu O, Hess GT, Ego BK, Li A, Truong A, Trevino AE, Spees K, Yao D, Kaplow IM, Greenside PG, Morgens DW, Phanstiel DH, Snyder MP, Bintu L, Greenleaf WJ, Kundaje A, Bassik MC. Mitigation of off-target toxicity in CRISPR-Cas9 screens for essential non-coding elements. Nat Commun. 2019 09 06; 10(1):4063. PMID: 31492858; PMCID: PMC6731277.
    Citations: 39     Fields:    Translation:HumansCells
  6. Huston NC, Tycko J, Tillotson EL, Wilson CJ, Myer VE, Jayaram H, Steinberg BE. Identification of Guide-Intrinsic Determinants of Cas9 Specificity. CRISPR J. 2019 06; 2:172-185. PMID: 31225747.
    Citations: 9     Fields:    Translation:Cells
  7. Tycko J, Barrera LA, Huston NC, Friedland AE, Wu X, Gootenberg JS, Abudayyeh OO, Myer VE, Wilson CJ, Hsu PD. Publisher Correction: Pairwise library screen systematically interrogates Staphylococcus aureus Cas9 specificity in human cells. Nat Commun. 2018 08 28; 9(1):3542. PMID: 30154463; PMCID: PMC6113259.
    Citations:    Fields:    
  8. Tycko J, Barrera LA, Huston NC, Friedland AE, Wu X, Gootenberg JS, Abudayyeh OO, Myer VE, Wilson CJ, Hsu PD. Pairwise library screen systematically interrogates Staphylococcus aureus Cas9 specificity in human cells. Nat Commun. 2018 07 27; 9(1):2962. PMID: 30054474.
    Citations: 15     Fields:    Translation:HumansCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.