Harvard Catalyst Profiles

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Chrysovalantis Voutouri, Ph.D.


Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Voutouri C, Hardin CC, Naranbhai V, Nikmaneshi MR, Khandekar MJ, Gainor JF, Stylianopoulos T, Munn LL, Jain RK. Mechanistic model for booster doses effectiveness in healthy, cancer, and immunosuppressed patients infected with SARS-CoV-2. Proc Natl Acad Sci U S A. 2023 Jan 17; 120(3):e2211132120. PMID: 36623200.
    Citations:    Fields:    Translation:HumansCells
  2. Mpekris F, Panagi M, Michael C, Voutouri C, Tsuchiya M, Wagatsuma C, Kinoh H, Osada A, Akinaga S, Yoshida S, Martin JD, Stylianopoulos T. Translational nanomedicine potentiates immunotherapy in sarcoma by normalizing the microenvironment. J Control Release. 2022 Dec 21; 353:956-964. PMID: 36516902.
    Citations:    Fields:    
  3. Panagi M, Mpekris F, Chen P, Voutouri C, Nakagawa Y, Martin JD, Hiroi T, Hashimoto H, Demetriou P, Pierides C, Samuel R, Stylianou A, Michael C, Fukushima S, Georgiou P, Papageorgis P, Papaphilippou PC, Koumas L, Costeas P, Ishii G, Kojima M, Kataoka K, Cabral H, Stylianopoulos T. Polymeric micelles effectively reprogram the tumor microenvironment to potentiate nano-immunotherapy in mouse breast cancer models. Nat Commun. 2022 11 22; 13(1):7165. PMID: 36418896; PMCID: PMC9684407.
    Citations:    Fields:    Translation:Animals
  4. Stylianou A, Mpekris F, Voutouri C, Papoui A, Constantinidou A, Kitiris E, Kailides M, Stylianopoulos T. Nanomechanical properties of solid tumors as treatment monitoring biomarkers. Acta Biomater. 2022 Dec; 154:324-334. PMID: 36244596.
    Citations:    Fields:    Translation:HumansAnimals
  5. Mpekris F, Voutouri C, Panagi M, Baish JW, Jain RK, Stylianopoulos T. Normalizing tumor microenvironment with nanomedicine and metronomic therapy to improve immunotherapy. J Control Release. 2022 05; 345:190-199. PMID: 35271911; PMCID: PMC9168447.
    Citations: 1     Fields:    Translation:Animals
  6. Subudhi S, Voutouri C, Hardin CC, Nikmaneshi MR, Patel AB, Verma A, Khandekar MJ, Dutta S, Stylianopoulos T, Jain RK, Munn LL. Strategies to minimize heterogeneity and optimize clinical trials in Acute Respiratory Distress Syndrome (ARDS): Insights from mathematical modelling. EBioMedicine. 2022 Jan; 75:103809. PMID: 35033853; PMCID: PMC8757652.
    Citations:    Fields:    Translation:HumansCells
  7. Voutouri C, Nikmaneshi MR, Hardin CC, Patel AB, Verma A, Khandekar MJ, Dutta S, Stylianopoulos T, Munn LL, Jain RK. In silico dynamics of COVID-19 phenotypes for optimizing clinical management. Proc Natl Acad Sci U S A. 2021 01 19; 118(3). PMID: 33402434.
    Citations: 15     Fields:    Translation:HumansCells
  8. Mpekris F, Panagi M, Voutouri C, Martin JD, Samuel R, Takahashi S, Gotohda N, Suzuki T, Papageorgis P, Demetriou P, Pierides C, Koumas L, Costeas P, Kojima M, Ishii G, Constantinidou A, Kataoka K, Cabral H, Stylianopoulos T. Normalizing the Microenvironment Overcomes Vessel Compression and Resistance to Nano-immunotherapy in Breast Cancer Lung Metastasis. Adv Sci (Weinh). 2021 Feb; 8(3):2001917. PMID: 33552852; PMCID: PMC7856901.
    Citations: 14     Fields:    
  9. Voutouri C, Nikmaneshi MR, Hardin CC, Patel AB, Verma A, Khandekar MJ, Dutta S, Stylianopoulos T, Munn LL, Jain RK. In silico dynamics of COVID-19 phenotypes for optimizing clinical management. Res Sq. 2020 Sep 03. PMID: 32908974.
  10. Katsamba I, Evangelidis P, Voutouri C, Tsamis A, Vavourakis V, Stylianopoulos T. Biomechanical modelling of spinal tumour anisotropic growth. Proc Math Phys Eng Sci. 2020 Jun; 476(2238):20190364. PMID: 32831581; PMCID: PMC7428026.
    Citations: 2     
  11. Karagiorgis S, Tsamis A, Voutouri C, Turcu R, Porav SA, Socoliuc V, Vekas L, Louca M, Stylianopoulos T, Vavourakis V, Krasia-Christoforou T. Engineered magnetoactive collagen hydrogels with tunable and predictable mechanical response. Mater Sci Eng C Mater Biol Appl. 2020 Sep; 114:111089. PMID: 32994019.
    Citations: 2     Fields:    
  12. Gkretsi V, Stylianou A, Kalli M, Louca M, Voutouri C, Zaravinos A, Stylianopoulos T. Silencing of Growth Differentiation Factor-15 Promotes Breast Cancer Cell Invasion by Down-regulating Focal Adhesion Genes. Anticancer Res. 2020 Mar; 40(3):1375-1385. PMID: 32132034.
    Citations: 2     Fields:    Translation:HumansCells
  13. Mpekris F, Voutouri C, Baish JW, Duda DG, Munn LL, Stylianopoulos T, Jain RK. Combining microenvironment normalization strategies to improve cancer immunotherapy. Proc Natl Acad Sci U S A. 2020 02 18; 117(7):3728-3737. PMID: 32015113.
    Citations: 58     Fields:    Translation:HumansCells
  14. Panagi M, Voutouri C, Mpekris F, Papageorgis P, Martin MR, Martin JD, Demetriou P, Pierides C, Polydorou C, Stylianou A, Louca M, Koumas L, Costeas P, Kataoka K, Cabral H, Stylianopoulos T. TGF-ß inhibition combined with cytotoxic nanomedicine normalizes triple negative breast cancer microenvironment towards anti-tumor immunity. Theranostics. 2020; 10(4):1910-1922. PMID: 32042344; PMCID: PMC6993226.
    Citations: 48     Fields:    Translation:AnimalsCellsPHPublic Health
  15. Kalli M, Voutouri C, Minia A, Pliaka V, Fotis C, Alexopoulos LG, Stylianopoulos T. Mechanical Compression Regulates Brain Cancer Cell Migration Through MEK1/Erk1 Pathway Activation and GDF15 Expression. Front Oncol. 2019; 9:992. PMID: 31612114; PMCID: PMC6777415.
    Citations: 13     
  16. Martin JD, Panagi M, Wang C, Khan TT, Martin MR, Voutouri C, Toh K, Papageorgis P, Mpekris F, Polydorou C, Ishii G, Takahashi S, Gotohda N, Suzuki T, Wilhelm ME, Melo VA, Quader S, Norimatsu J, Lanning RM, Kojima M, Stuber MD, Stylianopoulos T, Kataoka K, Cabral H. Dexamethasone Increases Cisplatin-Loaded Nanocarrier Delivery and Efficacy in Metastatic Breast Cancer by Normalizing the Tumor Microenvironment. ACS Nano. 2019 06 25; 13(6):6396-6408. PMID: 31187975.
    Citations: 27     Fields:    Translation:AnimalsCells
  17. Voutouri C, Kirkpatrick ND, Chung E, Mpekris F, Baish JW, Munn LL, Fukumura D, Stylianopoulos T, Jain RK. Experimental and computational analyses reveal dynamics of tumor vessel cooption and optimal treatment strategies. Proc Natl Acad Sci U S A. 2019 02 12; 116(7):2662-2671. PMID: 30700544; PMCID: PMC6377457.
    Citations: 28     Fields:    Translation:HumansAnimalsCells
  18. Voutouri C, Stylianopoulos T. Accumulation of mechanical forces in tumors is related to hyaluronan content and tissue stiffness. PLoS One. 2018; 13(3):e0193801. PMID: 29561855; PMCID: PMC5862434.
    Citations: 15     Fields:    Translation:HumansAnimalsCells
  19. Mpekris F, Papageorgis P, Polydorou C, Voutouri C, Kalli M, Pirentis AP, Stylianopoulos T. Sonic-hedgehog pathway inhibition normalizes desmoplastic tumor microenvironment to improve chemo- and nanotherapy. J Control Release. 2017 09 10; 261:105-112. PMID: 28662901; PMCID: PMC5548264.
    Citations: 29     Fields:    Translation:HumansAnimalsCells
  20. Polydorou C, Mpekris F, Papageorgis P, Voutouri C, Stylianopoulos T. Pirfenidone normalizes the tumor microenvironment to improve chemotherapy. Oncotarget. 2017 Apr 11; 8(15):24506-24517. PMID: 28445938; PMCID: PMC5421866.
    Citations: 73     Fields:    Translation:Humans
  21. Papageorgis P, Polydorou C, Mpekris F, Voutouri C, Agathokleous E, Kapnissi-Christodoulou CP, Stylianopoulos T. Tranilast-induced stress alleviation in solid tumors improves the efficacy of chemo- and nanotherapeutics in a size-independent manner. Sci Rep. 2017 04 10; 7:46140. PMID: 28393881; PMCID: PMC5385877.
    Citations: 42     Fields:    Translation:HumansAnimalsCells
  22. Voutouri C, Polydorou C, Papageorgis P, Gkretsi V, Stylianopoulos T. Hyaluronan-Derived Swelling of Solid Tumors, the Contribution of Collagen and Cancer Cells, and Implications for Cancer Therapy. Neoplasia. 2016 Dec; 18(12):732-741. PMID: 27886639; PMCID: PMC5122704.
    Citations: 42     Fields:    Translation:HumansAnimalsCells
  23. Wijeratne PA, Vavourakis V, Hipwell JH, Voutouri C, Papageorgis P, Stylianopoulos T, Evans A, Hawkes DJ. Multiscale modelling of solid tumour growth: the effect of collagen micromechanics. Biomech Model Mechanobiol. 2016 10; 15(5):1079-90. PMID: 26564173; PMCID: PMC4762195.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  24. Kepola EJ, Loizou E, Patrickios CS, Leontidis E, Voutouri C, Stylianopoulos T, Schweins R, Gradzielski M, Krumm C, Tiller JC, Kushnir M, Wesdemiotis C. Amphiphilic Polymer Conetworks Based on End-Linked "Core-First" Star Block Copolymers: Structure Formation with Long-Range Order. ACS Macro Lett. 2015 Oct 20; 4(10):1163-1168. PMID: 35614799.
    Citations:    Fields:    
  25. Pirentis AP, Polydorou C, Papageorgis P, Voutouri C, Mpekris F, Stylianopoulos T. Remodeling of extracellular matrix due to solid stress accumulation during tumor growth. Connect Tissue Res. 2015; 56(5):345-54. PMID: 26194953; PMCID: PMC4597369.
    Citations: 9     Fields:    Translation:AnimalsCells
  26. Voutouri C, Mpekris F, Papageorgis P, Odysseos AD, Stylianopoulos T. Role of constitutive behavior and tumor-host mechanical interactions in the state of stress and growth of solid tumors. PLoS One. 2014; 9(8):e104717. PMID: 25111061; PMCID: PMC4128744.
    Citations: 36     Fields:    Translation:HumansCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.