Harvard Catalyst Profiles

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Yu-Hua Tseng, Ph.D.

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The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. S10OD028568 (TSENG, YU-HUA) Sep 16, 2020 - Sep 15, 2021
    Small Animal High Resolution Metabolic Analysis System
    Role: Principal Investigator
  2. R01DK122808 (TSENG, YU-HUA) Apr 1, 2020 - Jan 31, 2024
    Role of brown fat-derived specialized pro-resolving lipid mediators in inflammation and metabolism
    Role: Principal Investigator
  3. R01DK102898 (TSENG, YU-HUA) Jul 3, 2015 - Mar 31, 2025
    Fibroblast Growth Factor and Energy Metabolism
    Role: Principal Investigator
  4. R01DK077097 (TSENG, YU-HUA) Dec 1, 2006 - Apr 30, 2021
    Regulation of human brown and beige adipocyte differentiation and function
    Role: Principal Investigator
  5. R21DK070722 (TSENG, YU-HUA) Apr 1, 2005 - Mar 31, 2007
    Role of BMPs on Brown Adipogenesis and Thermogenesis
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Townsend KL, Madden CJ, Blaszkiewicz M, McDougall L, Tupone D, Lynes MD, Mishina Y, Yu P, Morrison SF, Tseng YH. Reestablishment of Energy Balance in a Male Mouse Model With POMC Neuron Deletion of BMPR1A. Endocrinology. 2017 12 01; 158(12):4233-4245. PMID: 29040444; PMCID: PMC5711385.
    Citations: 6     Fields:    Translation:AnimalsCells
  2. Shamsi F, Zhang H, Tseng YH. MicroRNA Regulation of Brown Adipogenesis and Thermogenic Energy Expenditure. Front Endocrinol (Lausanne). 2017; 8:205. PMID: 28878735.
    Citations: 15     Fields:    
  3. Hiraike Y, Waki H, Yu J, Nakamura M, Miyake K, Nagano G, Nakaki R, Suzuki K, Kobayashi H, Yamamoto S, Sun W, Aoyama T, Hirota Y, Ohno H, Oki K, Yoneda M, White AP, Tseng YH, Cypess AM, Larsen TJ, Jespersen NZ, Scheele C, Tsutsumi S, Aburatani H, Yamauchi T, Kadowaki T. NFIA co-localizes with PPAR? and transcriptionally controls the brown fat gene program. Nat Cell Biol. 2017 Sep; 19(9):1081-1092. PMID: 28812581; PMCID: PMC5885759.
    Citations: 28     Fields:    Translation:AnimalsCells
  4. Lynes MD, Tseng YH. Deciphering adipose tissue heterogeneity. Ann N Y Acad Sci. 2018 01; 1411(1):5-20. PMID: 28763833; PMCID: PMC5788721.
    Citations: 34     Fields:    Translation:HumansAnimalsCells
  5. Mo Q, Salley J, Roshan T, Baer LA, May FJ, Jaehnig EJ, Lehnig AC, Guo X, Tong Q, Nuotio-Antar AM, Shamsi F, Tseng YH, Stanford KI, Chen MH. Identification and characterization of a supraclavicular brown adipose tissue in mice. JCI Insight. 2017 Jun 02; 2(11). PMID: 28570265.
    Citations: 10     Fields:    
  6. Hou Y, Kitaguchi T, Kriszt R, Tseng YH, Raghunath M, Suzuki M. Ca2+-associated triphasic pH changes in mitochondria during brown adipocyte activation. Mol Metab. 2017 08; 6(8):797-808. PMID: 28752044.
    Citations: 4     Fields:    Translation:AnimalsCells
  7. Kriszt R, Arai S, Itoh H, Lee MH, Goralczyk AG, Ang XM, Cypess AM, White AP, Shamsi F, Xue R, Lee JY, Lee SC, Hou Y, Kitaguchi T, Sudhaharan T, Ishiwata S, Lane EB, Chang YT, Tseng YH, Suzuki M, Raghunath M. Optical visualisation of thermogenesis in stimulated single-cell brown adipocytes. Sci Rep. 2017 05 03; 7(1):1383. PMID: 28469146.
    Citations: 24     Fields:    Translation:HumansAnimalsCells
  8. Lynes MD, Leiria LO, Lundh M, Bartelt A, Shamsi F, Huang TL, Takahashi H, Hirshman MF, Schlein C, Lee A, Baer LA, May FJ, Gao F, Narain NR, Chen EY, Kiebish MA, Cypess AM, Blüher M, Goodyear LJ, Hotamisligil GS, Stanford KI, Tseng YH. The cold-induced lipokine 12,13-diHOME promotes fatty acid transport into brown adipose tissue. Nat Med. 2017 May; 23(5):631-637. PMID: 28346411; PMCID: PMC5699924.
    Citations: 135     Fields:    Translation:HumansAnimalsCells
  9. Shamsi F, Tseng YH. Protocols for Generation of Immortalized Human Brown and White Preadipocyte Cell Lines. Methods Mol Biol. 2017; 1566:77-85. PMID: 28244042; PMCID: PMC5870121.
    Citations: 8     Fields:    Translation:HumansCells
  10. Zhu Y, Gao Y, Tao C, Shao M, Zhao S, Huang W, Yao T, Johnson JA, Liu T, Cypess AM, Gupta O, Holland WL, Gupta RK, Spray DC, Tanowitz HB, Cao L, Lynes MD, Tseng YH, Elmquist JK, Williams KW, Lin HV, Scherer PE. Connexin 43 Mediates White Adipose Tissue Beiging by Facilitating the Propagation of Sympathetic Neuronal Signals. Cell Metab. 2016 09 13; 24(3):420-433. PMID: 27626200.
    Citations: 47     Fields:    Translation:AnimalsCells
  11. Gao F, McDaniel J, Chen EY, Rockwell H, Lynes MD, Tseng YH, Sarangarajan R, Narain NR, Kiebish MA. Monoacylglycerol Analysis Using MS/MS(ALL) Quadruple Time of Flight Mass Spectrometry. Metabolites. 2016 Aug 17; 6(3). PMID: 27548241; PMCID: PMC5041124.
    Citations: 11     
  12. Schulz TJ, Graja A, Huang TL, Xue R, An D, Poehle-Kronawitter S, Lynes MD, Tolkachov A, O'Sullivan LE, Hirshman MF, Schupp M, Goodyear LJ, Mishina Y, Tseng YH. Loss of BMP receptor type 1A in murine adipose tissue attenuates age-related onset of insulin resistance. Diabetologia. 2016 08; 59(8):1769-77. PMID: 27209464.
    Citations: 5     Fields:    Translation:AnimalsCells
  13. Jeong HW, Choi RH, McClellan JL, Piroli GG, Frizzell N, Tseng YH, Goodyear LJ, Koh HJ. Tribbles 3 inhibits brown adipocyte differentiation and function by suppressing insulin signaling. Biochem Biophys Res Commun. 2016 Feb 19; 470(4):783-91. PMID: 26801556; PMCID: PMC4768059.
    Citations: 3     Fields:    Translation:AnimalsCells
  14. Ashcroft F, Pearce E, Partridge L, Suomalainen A, Brunet A, Schulze A, Tseng YH, Sethi JK, Reue K, Kingwell B, McNally E, Cnop M, Hevener AL, Diano S. Women in Metabolism: Part 3. Cell Metab. 2015 Dec 01; 22(6):949-53. PMID: 26636490.
    Citations:    Fields:    Translation:Humans
  15. Unser AM, Mooney B, Corr DT, Tseng YH, Xie Y. 3D brown adipogenesis to create "Brown-Fat-in-Microstrands". Biomaterials. 2016 Jan; 75:123-134. PMID: 26496384.
    Citations: 5     Fields:    Translation:AnimalsCells
  16. Zhang H, Guan M, Townsend KL, Huang TL, An D, Yan X, Xue R, Schulz TJ, Winnay J, Mori M, Hirshman MF, Kristiansen K, Tsang JS, White AP, Cypess AM, Goodyear LJ, Tseng YH. MicroRNA-455 regulates brown adipogenesis via a novel HIF1an-AMPK-PGC1a signaling network. EMBO Rep. 2015 Oct; 16(10):1378-93. PMID: 26303948.
    Citations: 58     Fields:    Translation:HumansAnimalsCells
  17. Zhang X, Tian Y, Zhang H, Kavishwar A, Lynes M, Brownell AL, Sun H, Tseng YH, Moore A, Ran C. Curcumin analogues as selective fluorescence imaging probes for brown adipose tissue and monitoring browning. Sci Rep. 2015 Aug 13; 5:13116. PMID: 26269357.
    Citations: 19     Fields:    Translation:AnimalsCells
  18. Xue R, Lynes MD, Dreyfuss JM, Shamsi F, Schulz TJ, Zhang H, Huang TL, Townsend KL, Li Y, Takahashi H, Weiner LS, White AP, Lynes MS, Rubin LL, Goodyear LJ, Cypess AM, Tseng YH. Clonal analyses and gene profiling identify genetic biomarkers of the thermogenic potential of human brown and white preadipocytes. Nat Med. 2015 Jul; 21(7):760-8. PMID: 26076036; PMCID: PMC4496292.
    Citations: 121     Fields:    Translation:HumansCells
  19. Lynes MD, Tseng YH. The Thermogenic Circuit: Regulators of Thermogenic Competency and Differentiation. Genes Dis. 2015 Jun; 2(2):164-172. PMID: 26491708; PMCID: PMC4610149.
    Citations: 9     
  20. Shinoda K, Luijten IH, Hasegawa Y, Hong H, Sonne SB, Kim M, Xue R, Chondronikola M, Cypess AM, Tseng YH, Nedergaard J, Sidossis LS, Kajimura S. Genetic and functional characterization of clonally derived adult human brown adipocytes. Nat Med. 2015 Apr; 21(4):389-94. PMID: 25774848.
    Citations: 205     Fields:    Translation:HumansAnimalsCells
  21. Lynes MD, Schulz TJ, Pan AJ, Tseng YH. Disruption of insulin signaling in Myf5-expressing progenitors leads to marked paucity of brown fat but normal muscle development. Endocrinology. 2015 May; 156(5):1637-47. PMID: 25625589; PMCID: PMC4398768.
    Citations: 10     Fields:    Translation:AnimalsCells
  22. Stanford KI, Middelbeek RJ, Townsend KL, Lee MY, Takahashi H, So K, Hitchcox KM, Markan KR, Hellbach K, Hirshman MF, Tseng YH, Goodyear LJ. A novel role for subcutaneous adipose tissue in exercise-induced improvements in glucose homeostasis. Diabetes. 2015 Jun; 64(6):2002-14. PMID: 25605808; PMCID: PMC4439563.
    Citations: 135     Fields:    Translation:Animals
  23. Lynes MD, Tseng YH. Unwiring the transcriptional heat circuit. Proc Natl Acad Sci U S A. 2014 Oct 07; 111(40):14318-9. PMID: 25261553.
    Citations: 3     Fields:    Translation:AnimalsCells
  24. Ussar S, Lee KY, Dankel SN, Boucher J, Haering MF, Kleinridders A, Thomou T, Xue R, Macotela Y, Cypess AM, Tseng YH, Mellgren G, Kahn CR. ASC-1, PAT2, and P2RX5 are cell surface markers for white, beige, and brown adipocytes. Sci Transl Med. 2014 Jul 30; 6(247):247ra103. PMID: 25080478.
    Citations: 84     Fields:    Translation:HumansAnimalsCells
  25. Kong X, Banks A, Liu T, Kazak L, Rao RR, Cohen P, Wang X, Yu S, Lo JC, Tseng YH, Cypess AM, Xue R, Kleiner S, Kang S, Spiegelman BM, Rosen ED. IRF4 is a key thermogenic transcriptional partner of PGC-1a. Cell. 2014 Jul 03; 158(1):69-83. PMID: 24995979.
    Citations: 124     Fields:    Translation:HumansAnimalsCells
  26. Huang P, Schulz TJ, Beauvais A, Tseng YH, Gussoni E. Intramuscular adipogenesis is inhibited by myo-endothelial progenitors with functioning Bmpr1a signalling. Nat Commun. 2014 Jun 05; 5:4063. PMID: 24898859.
    Citations: 21     Fields:    Translation:AnimalsCells
  27. Lee JH, Bhang DH, Beede A, Huang TL, Stripp BR, Bloch KD, Wagers AJ, Tseng YH, Ryeom S, Kim CF. Lung stem cell differentiation in mice directed by endothelial cells via a BMP4-NFATc1-thrombospondin-1 axis. Cell. 2014 Jan 30; 156(3):440-55. PMID: 24485453.
    Citations: 188     Fields:    Translation:AnimalsCells
  28. Mwangi SM, Nezami BG, Obukwelu B, Anitha M, Marri S, Fu P, Epperson MF, Le NA, Shanmugam M, Sitaraman SV, Tseng YH, Anania FA, Srinivasan S. Glial cell line-derived neurotrophic factor protects against high-fat diet-induced obesity. Am J Physiol Gastrointest Liver Physiol. 2014 Mar; 306(6):G515-25. PMID: 24458024.
    Citations: 16     Fields:    Translation:AnimalsCells
  29. Castiglioni A, Hettmer S, Lynes MD, Rao TN, Tchessalova D, Sinha I, Lee BT, Tseng YH, Wagers AJ. Isolation of Progenitors that Exhibit Myogenic/Osteogenic Bipotency In Vitro by Fluorescence-Activated Cell Sorting from Human Fetal Muscle. Stem Cell Reports. 2014 Jan 14; 2(1):92-106. PMID: 28039752.
  30. Castiglioni A, Hettmer S, Lynes MD, Rao TN, Tchessalova D, Sinha I, Lee BT, Tseng YH, Wagers AJ. Isolation of progenitors that exhibit myogenic/osteogenic bipotency in vitro by fluorescence-activated cell sorting from human fetal muscle. Stem Cell Reports. 2014 Jan 14; 2(1):92-106. PMID: 24678452.
    Citations: 37     Fields:    Translation:HumansAnimalsCells
  31. Townsend KL, Tseng YH. Brown fat fuel utilization and thermogenesis. Trends Endocrinol Metab. 2014 Apr; 25(4):168-77. PMID: 24389130.
    Citations: 119     Fields:    Translation:HumansAnimals
  32. Lau AM, Tseng YH, Schulz TJ. Adipogenic fate commitment of muscle-derived progenitor cells: isolation, culture, and differentiation. Methods Mol Biol. 2014; 1213:229-43. PMID: 25173387.
    Citations: 4     Fields:    Translation:AnimalsCells
  33. Cypess AM, Doyle AN, Sass CA, Huang TL, Mowschenson PM, Rosen HN, Tseng YH, Palmer EL, Kolodny GM. Quantification of human and rodent brown adipose tissue function using 99mTc-methoxyisobutylisonitrile SPECT/CT and 18F-FDG PET/CT. J Nucl Med. 2013 Nov; 54(11):1896-901. PMID: 24071505.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
  34. Schulz TJ, Tseng YH. Systemic control of brown fat thermogenesis: integration of peripheral and central signals. Ann N Y Acad Sci. 2013 Oct; 1302:35-41. PMID: 24111913.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  35. Schulz TJ, Tseng YH. Brown adipose tissue: development, metabolism and beyond. Biochem J. 2013 Jul 15; 453(2):167-78. PMID: 23805974.
    Citations: 69     Fields:    Translation:HumansAnimalsCells
  36. Cypess AM, White AP, Vernochet C, Schulz TJ, Xue R, Sass CA, Huang TL, Roberts-Toler C, Weiner LS, Sze C, Chacko AT, Deschamps LN, Herder LM, Truchan N, Glasgow AL, Holman AR, Gavrila A, Hasselgren PO, Mori MA, Molla M, Tseng YH. Anatomical localization, gene expression profiling and functional characterization of adult human neck brown fat. Nat Med. 2013 May; 19(5):635-9. PMID: 23603815.
    Citations: 317     Fields:    Translation:HumansAnimalsCells
  37. Ziogas DC, Gras-Miralles B, Mustafa S, Geiger BM, Najarian RM, Nagel JM, Flier SN, Popov Y, Tseng YH, Kokkotou E. Anti-melanin-concentrating hormone treatment attenuates chronic experimental colitis and fibrosis. Am J Physiol Gastrointest Liver Physiol. 2013 May 15; 304(10):G876-84. PMID: 23538494.
    Citations: 5     Fields:    Translation:AnimalsCells
  38. Schulz TJ, Huang P, Huang TL, Xue R, McDougall LE, Townsend KL, Cypess AM, Mishina Y, Gussoni E, Tseng YH. Brown-fat paucity due to impaired BMP signalling induces compensatory browning of white fat. Nature. 2013 Mar 21; 495(7441):379-83. PMID: 23485971.
    Citations: 194     Fields:    Translation:AnimalsCells
  39. Liew CW, Boucher J, Cheong JK, Vernochet C, Koh HJ, Mallol C, Townsend K, Langin D, Kawamori D, Hu J, Tseng YH, Hellerstein MK, Farmer SR, Goodyear L, Doria A, Blüher M, Hsu SI, Kulkarni RN. Ablation of TRIP-Br2, a regulator of fat lipolysis, thermogenesis and oxidative metabolism, prevents diet-induced obesity and insulin resistance. Nat Med. 2013 Feb; 19(2):217-26. PMID: 23291629.
    Citations: 38     Fields:    Translation:HumansAnimalsCells
  40. Müller TD, Lee SJ, Jastroch M, Kabra D, Stemmer K, Aichler M, Abplanalp B, Ananthakrishnan G, Bhardwaj N, Collins S, Divanovic S, Endele M, Finan B, Gao Y, Habegger KM, Hembree J, Heppner KM, Hofmann S, Holland J, Küchler D, Kutschke M, Krishna R, Lehti M, Oelkrug R, Ottaway N, Perez-Tilve D, Raver C, Walch AK, Schriever SC, Speakman J, Tseng YH, Diaz-Meco M, Pfluger PT, Moscat J, Tschöp MH. p62 links ß-adrenergic input to mitochondrial function and thermogenesis. J Clin Invest. 2013 Jan; 123(1):469-78. PMID: 23257354; PMCID: PMC3533288.
    Citations: 64     Fields:    Translation:AnimalsCells
  41. Stanford KI, Middelbeek RJ, Townsend KL, An D, Nygaard EB, Hitchcox KM, Markan KR, Nakano K, Hirshman MF, Tseng YH, Goodyear LJ. Brown adipose tissue regulates glucose homeostasis and insulin sensitivity. J Clin Invest. 2013 Jan; 123(1):215-23. PMID: 23221344; PMCID: PMC3533266.
    Citations: 446     Fields:    Translation:Animals
  42. Townsend KL, An D, Lynes MD, Huang TL, Zhang H, Goodyear LJ, Tseng YH. Increased mitochondrial activity in BMP7-treated brown adipocytes, due to increased CPT1- and CD36-mediated fatty acid uptake. Antioxid Redox Signal. 2013 Jul 20; 19(3):243-57. PMID: 22938691.
    Citations: 40     Fields:    Translation:AnimalsCells
  43. Macotela Y, Emanuelli B, Mori MA, Gesta S, Schulz TJ, Tseng YH, Kahn CR. Intrinsic differences in adipocyte precursor cells from different white fat depots. Diabetes. 2012 Jul; 61(7):1691-9. PMID: 22596050; PMCID: PMC3379665.
    Citations: 139     Fields:    Translation:AnimalsCells
  44. Townsend KL, Suzuki R, Huang TL, Jing E, Schulz TJ, Lee K, Taniguchi CM, Espinoza DO, McDougall LE, Zhang H, He TC, Kokkotou E, Tseng YH. Bone morphogenetic protein 7 (BMP7) reverses obesity and regulates appetite through a central mTOR pathway. FASEB J. 2012 May; 26(5):2187-96. PMID: 22331196; PMCID: PMC3336788.
    Citations: 48     Fields:    Translation:AnimalsCells
  45. Fujiwara K, Hasegawa K, Ohkumo T, Miyoshi H, Tseng YH, Yoshikawa K. Necdin controls proliferation of white adipocyte progenitor cells. PLoS One. 2012; 7(1):e30948. PMID: 22292082.
    Citations: 26     Fields:    Translation:AnimalsCells
  46. Townsend K, Tseng YH. Brown adipose tissue: Recent insights into development, metabolic function and therapeutic potential. Adipocyte. 2012 Jan 01; 1(1):13-24. PMID: 23700507.
    Citations: 69     Fields:    
  47. Cypess AM, Zhang H, Schulz TJ, Huang TL, Espinoza DO, Kristiansen K, Unterman TG, Tseng YH. Insulin/IGF-I regulation of necdin and brown adipocyte differentiation via CREB- and FoxO1-associated pathways. Endocrinology. 2011 Oct; 152(10):3680-9. PMID: 21862615; PMCID: PMC3176640.
    Citations: 22     Fields:    Translation:AnimalsCells
  48. Schleinitz D, Klöting N, Böttcher Y, Wolf S, Dietrich K, Tönjes A, Breitfeld J, Enigk B, Halbritter J, Körner A, Schön MR, Jenkner J, Tseng YH, Lohmann T, Dressler M, Stumvoll M, Blüher M, Kovacs P. Genetic and evolutionary analyses of the human bone morphogenetic protein receptor 2 (BMPR2) in the pathophysiology of obesity. PLoS One. 2011 Feb 02; 6(2):e16155. PMID: 21311592; PMCID: PMC3032727.
    Citations: 24     Fields:    Translation:Humans
  49. Schulz TJ, Huang TL, Tran TT, Zhang H, Townsend KL, Shadrach JL, Cerletti M, McDougall LE, Giorgadze N, Tchkonia T, Schrier D, Falb D, Kirkland JL, Wagers AJ, Tseng YH. Identification of inducible brown adipocyte progenitors residing in skeletal muscle and white fat. Proc Natl Acad Sci U S A. 2011 Jan 04; 108(1):143-8. PMID: 21173238.
    Citations: 238     Fields:    Translation:HumansAnimalsCells
  50. Zhang H, Schulz TJ, Espinoza DO, Huang TL, Emanuelli B, Kristiansen K, Tseng YH. Cross talk between insulin and bone morphogenetic protein signaling systems in brown adipogenesis. Mol Cell Biol. 2010 Sep; 30(17):4224-33. PMID: 20584981.
    Citations: 35     Fields:    Translation:AnimalsCells
  51. Tseng YH, Cypess AM, Kahn CR. Cellular bioenergetics as a target for obesity therapy. Nat Rev Drug Discov. 2010 Jun; 9(6):465-82. PMID: 20514071.
    Citations: 253     Fields:    Translation:HumansCells
  52. Boucher J, Tseng YH, Kahn CR. Insulin and insulin-like growth factor-1 receptors act as ligand-specific amplitude modulators of a common pathway regulating gene transcription. J Biol Chem. 2010 May 28; 285(22):17235-45. PMID: 20360006.
    Citations: 73     Fields:    Translation:HumansAnimalsCells
  53. Schulz TJ, Tseng YH. Emerging role of bone morphogenetic proteins in adipogenesis and energy metabolism. Cytokine Growth Factor Rev. 2009 Oct-Dec; 20(5-6):523-31. PMID: 19896888.
    Citations: 65     Fields:    Translation:HumansAnimals
  54. Wang WC, Chen HJ, Tseng YH, Lai YC. Identification of somatic mutations in the von Hippel-Lindau (VHL) gene in a patient with renal cell carcinoma. J Formos Med Assoc. 2009 Nov; 108(11):886-93. PMID: 19933033.
    Citations: 2     Fields:    Translation:Humans
  55. Böttcher Y, Unbehauen H, Klöting N, Ruschke K, Körner A, Schleinitz D, Tönjes A, Enigk B, Wolf S, Dietrich K, Koriath M, Scholz GH, Tseng YH, Dietrich A, Schön MR, Kiess W, Stumvoll M, Blüher M, Kovacs P. Adipose tissue expression and genetic variants of the bone morphogenetic protein receptor 1A gene (BMPR1A) are associated with human obesity. Diabetes. 2009 Sep; 58(9):2119-28. PMID: 19502417; PMCID: PMC2731538.
    Citations: 42     Fields:    Translation:Humans
  56. Cypess AM, Lehman S, Williams G, Tal I, Rodman D, Goldfine AB, Kuo FC, Palmer EL, Tseng YH, Doria A, Kolodny GM, Kahn CR. Identification and importance of brown adipose tissue in adult humans. N Engl J Med. 2009 Apr 09; 360(15):1509-17. PMID: 19357406; PMCID: PMC2859951.
    Citations: 1725     Fields:    Translation:HumansCells
  57. Tseng YH, Kokkotou E, Schulz TJ, Huang TL, Winnay JN, Taniguchi CM, Tran TT, Suzuki R, Espinoza DO, Yamamoto Y, Ahrens MJ, Dudley AT, Norris AW, Kulkarni RN, Kahn CR. New role of bone morphogenetic protein 7 in brown adipogenesis and energy expenditure. Nature. 2008 Aug 21; 454(7207):1000-4. PMID: 18719589.
    Citations: 470     Fields:    Translation:AnimalsCells
  58. Karagiannides I, Torres D, Tseng YH, Bowe C, Carvalho E, Espinoza D, Pothoulakis C, Kokkotou E. Substance P as a novel anti-obesity target. Gastroenterology. 2008 Mar; 134(3):747-55. PMID: 18325388; PMCID: PMC2359157.
    Citations: 19     Fields:    Translation:Animals
  59. Krüger M, Kratchmarova I, Blagoev B, Tseng YH, Kahn CR, Mann M. Dissection of the insulin signaling pathway via quantitative phosphoproteomics. Proc Natl Acad Sci U S A. 2008 Feb 19; 105(7):2451-6. PMID: 18268350.
    Citations: 107     Fields:    Translation:AnimalsCells
  60. Chang L, Zhang J, Tseng YH, Xie CQ, Ilany J, Brüning JC, Sun Z, Zhu X, Cui T, Youker KA, Yang Q, Day SM, Kahn CR, Chen YE. Rad GTPase deficiency leads to cardiac hypertrophy. Circulation. 2007 Dec 18; 116(25):2976-2983. PMID: 18056528; PMCID: PMC4207362.
    Citations: 37     Fields:    Translation:HumansAnimalsCells
  61. Gesta S, Tseng YH, Kahn CR. Developmental origin of fat: tracking obesity to its source. Cell. 2007 Oct 19; 131(2):242-56. PMID: 17956727.
    Citations: 576     Fields:    Translation:HumansAnimalsCells
  62. Mouche S, Mkaddem SB, Wang W, Katic M, Tseng YH, Carnesecchi S, Steger K, Foti M, Meier CA, Muzzin P, Kahn CR, Ogier-Denis E, Szanto I. Reduced expression of the NADPH oxidase NOX4 is a hallmark of adipocyte differentiation. Biochim Biophys Acta. 2007 Jul; 1773(7):1015-27. PMID: 17553579.
    Citations: 33     Fields:    Translation:HumansAnimalsCells
  63. Gunton JE, Kulkarni RN, Yim S, Okada T, Hawthorne WJ, Tseng YH, Roberson RS, Ricordi C, O'Connell PJ, Gonzalez FJ, Kahn CR. Loss of ARNT/HIF1beta mediates altered gene expression and pancreatic-islet dysfunction in human type 2 diabetes. Cell. 2005 Aug 12; 122(3):337-49. PMID: 16096055.
    Citations: 216     Fields:    Translation:HumansAnimalsCells
  64. Tseng YH, Butte AJ, Kokkotou E, Yechoor VK, Taniguchi CM, Kriauciunas KM, Cypess AM, Niinobe M, Yoshikawa K, Patti ME, Kahn CR. Prediction of preadipocyte differentiation by gene expression reveals role of insulin receptor substrates and necdin. Nat Cell Biol. 2005 Jun; 7(6):601-11. PMID: 15895078.
    Citations: 91     Fields:    Translation:AnimalsCells
  65. Fu M, Zhang J, Tseng YH, Cui T, Zhu X, Xiao Y, Mou Y, De Leon H, Chang MM, Hamamori Y, Kahn CR, Chen YE. Rad GTPase attenuates vascular lesion formation by inhibition of vascular smooth muscle cell migration. Circulation. 2005 Mar 01; 111(8):1071-7. PMID: 15710763.
    Citations: 24     Fields:    Translation:HumansAnimalsCells
  66. Ueki K, Kondo T, Tseng YH, Kahn CR. Central role of suppressors of cytokine signaling proteins in hepatic steatosis, insulin resistance, and the metabolic syndrome in the mouse. Proc Natl Acad Sci U S A. 2004 Jul 13; 101(28):10422-7. PMID: 15240880; PMCID: PMC478587.
    Citations: 132     Fields:    Translation:AnimalsCells
  67. Tseng YH, Kriauciunas KM, Kokkotou E, Kahn CR. Differential roles of insulin receptor substrates in brown adipocyte differentiation. Mol Cell Biol. 2004 Mar; 24(5):1918-29. PMID: 14966273.
    Citations: 79     Fields:    Translation:HumansAnimalsCells
  68. Cohen SE, Tseng YH, Michael MD, Kahn CR. Effects of insulin-sensitising agents in mice with hepatic insulin resistance. Diabetologia. 2004 Mar; 47(3):407-411. PMID: 14730378.
    Citations: 6     Fields:    Translation:Animals
  69. Tai YT, Podar K, Catley L, Tseng YH, Akiyama M, Shringarpure R, Burger R, Hideshima T, Chauhan D, Mitsiades N, Richardson P, Munshi NC, Kahn CR, Mitsiades C, Anderson KC. Insulin-like growth factor-1 induces adhesion and migration in human multiple myeloma cells via activation of beta1-integrin and phosphatidylinositol 3'-kinase/AKT signaling. Cancer Res. 2003 Sep 15; 63(18):5850-8. PMID: 14522909.
    Citations: 66     Fields:    Translation:HumansCells
  70. Tseng YH, Ueki K, Kriauciunas KM, Kahn CR. Differential roles of insulin receptor substrates in the anti-apoptotic function of insulin-like growth factor-1 and insulin. J Biol Chem. 2002 Aug 30; 277(35):31601-11. PMID: 12082100.
    Citations: 35     Fields:    Translation:AnimalsCells
  71. Ueki K, Fruman DA, Brachmann SM, Tseng YH, Cantley LC, Kahn CR. Molecular balance between the regulatory and catalytic subunits of phosphoinositide 3-kinase regulates cell signaling and survival. Mol Cell Biol. 2002 Feb; 22(3):965-77. PMID: 11784871.
    Citations: 99     Fields:    Translation:AnimalsCells
  72. Tseng YH, Vicent D, Zhu J, Niu Y, Adeyinka A, Moyers JS, Watson PH, Kahn CR. Regulation of growth and tumorigenicity of breast cancer cells by the low molecular weight GTPase Rad and nm23. Cancer Res. 2001 Mar 01; 61(5):2071-9. PMID: 11280768.
    Citations: 41     Fields:    Translation:HumansAnimalsCells
  73. Zhu J, Tseng YH, Kantor JD, Rhodes CJ, Zetter BR, Moyers JS, Kahn CR. Interaction of the Ras-related protein associated with diabetes rad and the putative tumor metastasis suppressor NM23 provides a novel mechanism of GTPase regulation. Proc Natl Acad Sci U S A. 1999 Dec 21; 96(26):14911-8. PMID: 10611312; PMCID: PMC24747.
    Citations: 47     Fields:    Translation:HumansAnimalsCells
  74. Tseng YH, Schuler LA. Transcriptional regulation of interleukin-1beta gene by interleukin-1beta itself is mediated in part by Oct-1 in thymic stromal cells. J Biol Chem. 1998 May 15; 273(20):12633-41. PMID: 9575225.
    Citations: 5     Fields:    Translation:AnimalsCells
  75. Tseng YH, Kessler MA, Schuler LA. Regulation of interleukin (IL)-1alpha, IL-1beta, and IL-6 expression by growth hormone and prolactin in bovine thymic stromal cells. Mol Cell Endocrinol. 1997 Apr 04; 128(1-2):117-27. PMID: 9140083.
    Citations: 7     Fields:    Translation:AnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.