Harvard Catalyst Profiles

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Nourhan Sami El Ahmar, M.D.


Lebanese American University, LebanonMD7/2020General medicine
Clemenceau medical center, Lebanon9/2021Pathology residency training
Lebanese American University, LebanonBSc7/2016Chemistry (pre-medicine)
2013 - 2016
Distinction list


The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. KC200280 (Nourhan El Ahmar) Sep 1, 2021 - Aug 31, 2023
    Department of Defense Awarding Office: USAMRAA
    Terminally Exhausted CD8+ Tumor-Infiltrating Lymphocytes and M2-Like Macrophages as Biomarkers of Resistance to First-Line Anti-PD-1 Therapy in Metastatic RCC
    Role Description: We propose a whole slide multiplex immunofluorescence characterization of T cell exhaustion and of hypothesized modifying factors in the microenvironment of kidney cancer. Roughly 70% of patients presenting a metastatic clear cell renal cell carcinoma (mccRCC) treated with anti-PD-1 do not benefit from therapy due to upfront or secondary resistance. Prior studies unveiled the fact that a high density of non-exhausted T cells (CD8+PD-1+TIM3-LAG3-) was predictive of response to anti-PD-1 therapy in previously treated patients with mccRCC. Despite this, most of the biology underlying immune checkpoint blockade remains unknown, and no biomarker is available in clinical practice to guide the prescription of these therapies. We will study the issue from a new angle with the goals of better understanding the biology, to provide markers of resistance to treatment, and identifying potential new therapeutic targets.
    Role: principal investigator

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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.