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Timothy Andrew Troppoli, Ph.D.

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Biography
University of Maryland, College ParkBS05/2014Biological Sciences
University of Maryland School of Medicine, BaltimorePhD09/2021Molecular Medicine

Overview
I am a psychiatric neuroscientist and electrophysiologist at the VABHS and Harvard Medical School studying populations of neurons in the basal forebrain that regulate sleep-wake behavior. I conducted my graduate dissertation research at the University of Maryland, Baltimore, where I investigated the rapid antidepressant-like properties and target engagement of negative allosteric modulators of a5-containing GABAARs, as well as the synaptic mechanisms of ketamine, hydroxynorketamines, and psilocybin.

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Troppoli TA, Zanos P, Georgiou P, Gould TD, Rudolph U, Thompson SM. Negative Allosteric Modulation of Gamma-Aminobutyric Acid A Receptors at a5 Subunit-Containing Benzodiazepine Sites Reverses Stress-Induced Anhedonia and Weakened Synaptic Function in Mice. Biol Psychiatry. 2021 Dec 15. PMID: 35120711.
    Citations:    Fields:    
  2. Hesselgrave N, Troppoli TA, Wulff AB, Cole AB, Thompson SM. Harnessing psilocybin: antidepressant-like behavioral and synaptic actions of psilocybin are independent of 5-HT2R activation in mice. Proc Natl Acad Sci U S A. 2021 04 27; 118(17). PMID: 33850049.
    Citations: 14     Fields:    Translation:Animals
  3. Zanos P, Highland JN, Liu X, Troppoli TA, Georgiou P, Lovett J, Morris PJ, Stewart BW, Thomas CJ, Thompson SM, Moaddel R, Gould TD. (R)-Ketamine exerts antidepressant actions partly via conversion to (2R,6R)-hydroxynorketamine, while causing adverse effects at sub-anaesthetic doses. Br J Pharmacol. 2019 07; 176(14):2573-2592. PMID: 30941749.
    Citations: 19     Fields:    Translation:Animals
  4. Lumsden EW, Troppoli TA, Myers SJ, Zanos P, Aracava Y, Kehr J, Lovett J, Kim S, Wang FH, Schmidt S, Jenne CE, Yuan P, Morris PJ, Thomas CJ, Zarate CA, Moaddel R, Traynelis SF, Pereira EFR, Thompson SM, Albuquerque EX, Gould TD. Antidepressant-relevant concentrations of the ketamine metabolite (2R,6R)-hydroxynorketamine do not block NMDA receptor function. Proc Natl Acad Sci U S A. 2019 03 12; 116(11):5160-5169. PMID: 30796190.
    Citations: 39     Fields:    Translation:AnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.