Harvard Catalyst Profiles

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Johann-Christoph Jann, M.D.


Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Altrock E, Sens-Albert C, Jann JC, Flach J, Riabov V, Schmitt N, Xu Q, Mehralivand A, Hecht A, Steiner L, Streuer A, Nowak V, Obländer J, Weimer N, Palme I, Jawhar A, Weis CA, Weyer V, Nolte F, Jawhar M, Metzgeroth G, Marx A, Groden C, Hofmann WK, Nowak D. Humanized three-dimensional scaffold xenotransplantation models for myelodysplastic syndromes. Exp Hematol. 2022 03; 107:38-50. PMID: 34952140.
    Citations:    Fields:    Translation:HumansAnimalsCells
  2. Triana S, Vonficht D, Jopp-Saile L, Raffel S, Lutz R, Leonce D, Antes M, Hernández-Malmierca P, Ordoñez-Rueda D, Ramasz B, Boch T, Jann JC, Nowak D, Hofmann WK, Müller-Tidow C, Hübschmann D, Alexandrov T, Benes V, Trumpp A, Paulsen M, Velten L, Haas S. Single-cell proteo-genomic reference maps of the hematopoietic system enable the purification and massive profiling of precisely defined cell states. Nat Immunol. 2021 12; 22(12):1577-1589. PMID: 34811546; PMCID: PMC8642243.
    Citations: 5     Fields:    Translation:HumansCells
  3. Flach J, Jann JC, Knaflic A, Riabov V, Streuer A, Altrock E, Xu Q, Schmitt N, Obländer J, Nowak V, Danner J, Mehralivand A, Hofmann F, Palme I, Jawhar A, Wuchter P, Metzgeroth G, Nolte F, Hofmann WK, Nowak D. Replication stress signaling is a therapeutic target in myelodysplastic syndromes with splicing factor mutations. Haematologica. 2021 11 01; 106(11):2906-2917. PMID: 33054116.
    Citations: 2     Fields:    Translation:HumansCells
  4. Jann JC, Mossner M, Riabov V, Altrock E, Schmitt N, Flach J, Xu Q, Nowak V, Obländer J, Palme I, Weimer N, Streuer A, Jawhar A, Darwich A, Jawhar M, Metzgeroth G, Nolte F, Hofmann WK, Nowak D. Bone marrow derived stromal cells from myelodysplastic syndromes are altered but not clonally mutated in vivo. Nat Commun. 2021 10 25; 12(1):6170. PMID: 34697318.
    Citations: 2     Fields:    Translation:HumansCells
  5. Jann JC, Tothova Z. Cohesin mutations in myeloid malignancies. Blood. 2021 08 26; 138(8):649-661. PMID: 34157074; PMCID: PMC8394903.
    Citations: 3     Fields:    Translation:HumansCells
  6. Schmitt N, Jann JC, Altrock E, Flach J, Danner J, Uhlig S, Streuer A, Knaflic A, Riabov V, Xu Q, Mehralivand A, Palme I, Nowak V, Obländer J, Weimer N, Haselmann V, Jawhar A, Darwich A, Weis CA, Marx A, Steiner L, Jawhar M, Metzgeroth G, Boch T, Nolte F, Hofmann WK, Nowak D. Preclinical evaluation of eltrombopag in a PDX model of myelodysplastic syndromes. Leukemia. 2022 01; 36(1):236-247. PMID: 34172896; PMCID: PMC8727300.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  7. Hecht A, Meyer JA, Jann JC, Sockel K, Giagounidis A, Götze KS, Letsch A, Haase D, Schlenk RF, Haferlach T, Schafhausen P, Bug G, Lübbert M, Thol F, Büsche G, Schuler E, Nowak V, Obländer J, Fey S, Müller N, Metzgeroth G, Hofmann WK, Germing U, Nolte F, Reinwald M, Nowak D. Genome-wide DNA methylation analysis pre- and post-lenalidomide treatment in patients with myelodysplastic syndrome with isolated deletion (5q). Ann Hematol. 2021 Jun; 100(6):1463-1471. PMID: 33903952.
    Citations:    Fields:    Translation:HumansCellsCTClinical Trials
  8. Velten L, Story BA, Hernández-Malmierca P, Raffel S, Leonce DR, Milbank J, Paulsen M, Demir A, Szu-Tu C, Frömel R, Lutz C, Nowak D, Jann JC, Pabst C, Boch T, Hofmann WK, Müller-Tidow C, Trumpp A, Haas S, Steinmetz LM. Identification of leukemic and pre-leukemic stem cells by clonal tracking from single-cell transcriptomics. Nat Commun. 2021 03 01; 12(1):1366. PMID: 33649320.
    Citations: 17     Fields:    Translation:HumansCells
  9. Riabov V, Mossner M, Stöhr A, Jann JC, Streuer A, Schmitt N, Knaflic A, Nowak V, Weimer N, Obländer J, Palme I, Schumann C, Baldus CD, Schulze TJ, Wuchter P, Röhl H, Jawhar A, Weiss C, Boch T, Metzgeroth G, Neumann M, Hofmann WK, Nolte F, Nowak D. High erythroferrone expression in CD71+ erythroid progenitors predicts superior survival in myelodysplastic syndromes. Br J Haematol. 2021 03; 192(5):879-891. PMID: 33486765.
    Citations: 1     Fields:    Translation:HumansCells
  10. Jann JC, Streuer A, Hecht A, Nolte F, Nowak V, Danner J, Obländer J, Palme I, Lengfelder E, Platzbecker U, Hofmann WK, Flach J, Nowak D. RNA-sequencing of acute promyelocytic leukemia primary blasts reveals novel molecular biomarkers of early death events. Leuk Lymphoma. 2020 12; 61(13):3066-3077. PMID: 32723198.
    Citations: 2     Fields:    Translation:HumansCells
  11. Zhu L, Hissa B, Gyorffy B, Jann JC, Yang C, Reissfelder C, Schölch S. Characterization of Stem-like Circulating Tumor Cells in Pancreatic Cancer. Diagnostics (Basel). 2020 May 15; 10(5). PMID: 32429174; PMCID: PMC7278018.
    Citations: 3     
  12. Jann JC, Nolte F, Mossner M, Flach J, Altrock E, Schmitt N, Röhl H, Jawhar A, Neumann U, Nowak V, Danner J, Obländer J, Palme I, Hofmann WK, Nowak D. Comparative analysis of clonal hematopoiesis of multipotent stem cells in healthy elderly in blood and bone marrow. Leuk Res. 2019 07; 82:15-18. PMID: 31132434.
    Citations:    Fields:    Translation:HumansCells
  13. Mährle T, Akyüz N, Fuchs P, Bonzanni N, Simnica D, Germing U, Asemissen AM, Jann JC, Nolte F, Hofmann WK, Nowak D, Binder M. Deep sequencing of bone marrow microenvironments of patients with del(5q) myelodysplastic syndrome reveals imprints of antigenic selection as well as generation of novel T-cell clusters as a response pattern to lenalidomide. Haematologica. 2019 07; 104(7):1355-1364. PMID: 30655375.
    Citations: 5     Fields:    Translation:HumansCellsCTClinical Trials
  14. Boch T, Luft T, Metzgeroth G, Mossner M, Jann JC, Nowak D, Meir F, Schumann C, Klemmer J, Brendel S, Fricke H, Kunz C, Weiß C, Hofmann WK, Nolte F. Safety and efficacy of the CD95-ligand inhibitor asunercept in transfusion-dependent patients with low and intermediate risk MDS. Leuk Res. 2018 05; 68:62-69. PMID: 29549809.
    Citations: 7     Fields:    Translation:HumansCTClinical Trials
  15. Jann JC, Nowak D, Nolte F, Fey S, Nowak V, Obländer J, Pressler J, Palme I, Xanthopoulos C, Fabarius A, Platzbecker U, Giagounidis A, Götze K, Letsch A, Haase D, Schlenk R, Bug G, Lübbert M, Ganser A, Germing U, Haferlach C, Hofmann WK, Mossner M. Accurate quantification of chromosomal lesions via short tandem repeat analysis using minimal amounts of DNA. J Med Genet. 2017 09; 54(9):640-650. PMID: 28600436; PMCID: PMC5574397.
    Citations:    Fields:    Translation:HumansCells
  16. Nolte F, Mossner M, Jann JC, Nowak D, Boch T, Müller NZ, Hofmann WK, Metzgeroth G. Concomitant MDS with isolated 5q deletion and MGUS: case report and review of molecular aspects. Eur J Haematol. 2017 Mar; 98(3):302-310. PMID: 27862375.
    Citations: 1     Fields:    Translation:HumansCells
  17. Mossner M, Jann JC, Wittig J, Nolte F, Fey S, Nowak V, Obländer J, Pressler J, Palme I, Xanthopoulos C, Boch T, Metzgeroth G, Röhl H, Witt SH, Dukal H, Klein C, Schmitt S, Gelß P, Platzbecker U, Balaian E, Fabarius A, Blum H, Schulze TJ, Meggendorfer M, Haferlach C, Trumpp A, Hofmann WK, Medyouf H, Nowak D. Mutational hierarchies in myelodysplastic syndromes dynamically adapt and evolve upon therapy response and failure. Blood. 2016 09 01; 128(9):1246-59. PMID: 27268087.
    Citations: 48     Fields:    Translation:HumansAnimals
  18. Nowak D, Liem NL, Mossner M, Klaumünzer M, Papa RA, Nowak V, Jann JC, Akagi T, Kawamata N, Okamoto R, Thoennissen NH, Kato M, Sanada M, Hofmann WK, Ogawa S, Marshall GM, Lock RB, Koeffler HP. Variegated clonality and rapid emergence of new molecular lesions in xenografts of acute lymphoblastic leukemia are associated with drug resistance. Exp Hematol. 2015 Jan; 43(1):32-43.e1-35. PMID: 25450514; PMCID: PMC5894481.
    Citations: 14     Fields:    Translation:HumansAnimalsCells
  19. Platzbecker U, Sockel K, Schönefeldt C, Nowak D, Helas S, Röllig C, Mossner M, Jann JC, Ehninger G, Hofmann WK, Bornhäuser M, Thiede C, Wermke M. Induction of short-term remission with single agent eltrombopag in refractory nucleophosmin-1-mutated acute myeloid leukemia. Haematologica. 2014 Dec; 99(12):e247-8. PMID: 25193964; PMCID: PMC4258752.
    Citations: 3     Fields:    Translation:HumansAnimals
  20. Ernst J, Jann JC, Biemann R, Koch HM, Fischer B. Effects of the environmental contaminants DEHP and TCDD on estradiol synthesis and aryl hydrocarbon receptor and peroxisome proliferator-activated receptor signalling in the human granulosa cell line KGN. Mol Hum Reprod. 2014 Sep; 20(9):919-28. PMID: 24950685.
    Citations: 17     Fields:    Translation:HumansCells
  21. Medyouf H, Mossner M, Jann JC, Nolte F, Raffel S, Herrmann C, Lier A, Eisen C, Nowak V, Zens B, Müdder K, Klein C, Obländer J, Fey S, Vogler J, Fabarius A, Riedl E, Roehl H, Kohlmann A, Staller M, Haferlach C, Müller N, John T, Platzbecker U, Metzgeroth G, Hofmann WK, Trumpp A, Nowak D. Myelodysplastic cells in patients reprogram mesenchymal stromal cells to establish a transplantable stem cell niche disease unit. Cell Stem Cell. 2014 Jun 05; 14(6):824-37. PMID: 24704494.
    Citations: 178     Fields:    Translation:HumansAnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.