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Susan James Hagen, PH.D.

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Mentoring
Role of Ammonia and H. Pylori Vacuolating Cytotoxin in Restitution
Full Time/Year Long, 07/01/98 - 06/30/99

Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01DK103046 (COHEN, DAVID E.) Jul 5, 2015 - May 31, 2020
    NIH/NIDDK
    Them1-Mediated Metabolic Regulation and Pathogenic Role in NAFLD
    Role: Co-Principal Investigator
  2. S10OD019988 (HAGEN, SUSAN J) Apr 1, 2015 - Mar 31, 2016
    NIH
    Wohlwend High Pressure Freezer for the BIDMC Electron Microscopy Core
    Role: Principal Investigator
  3. S10RR017927 (HAGEN, SUSAN J) May 1, 2006 - Apr 30, 2007
    NIH/NCRR
    Confocal Microscope for the BIDMC Imaging Core Facility
    Role: Principal Investigator
  4. R55DK044287 (HAGEN, SUSAN J) Sep 30, 1991 - Sep 29, 1993
    NIH/NIDDK
    DAMAGE/REPAIR OF THE INTESTINAL BRUSH BORDER
    Role: Principal Investigator
  5. P30DK034854 (LENCER, WAYNE I) Sep 30, 1984 - Nov 30, 2020
    NIH/NIDDK
    Integrated Epithelial and Mucosal Biology
    Role: Co-Principal Investigator
This researcher has shared information about their research resources in the eagle-i Network. To update or add resource records, contact eagle-i@hms.harvard.edu.
Histology Core (BIDMC) - Core services (7) and Instruments (4)
Electron Microscopy Core (BIDMC) - Core services (7) and Instruments (5)
Confocal Imaging Core (BIDMC) - Core services (2), Instruments (3) and Software (3)
HDDC Microscopy and Histopathology Core B - Core services (1) and Instruments (10)

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Hagen SJ. Unraveling a New Role for Claudins in Gastric Tumorigenesis. Cell Mol Gastroenterol Hepatol. 2019; 8(1):151-152. PMID: 31047875.
    Citations:    
  2. Hagen SJ, Ang LH, Zheng Y, Karahan SN, Wu J, Wang YE, Caron TJ, Gad AP, Muthupalani S, Fox JG. Loss of Tight Junction Protein Claudin 18 Promotes Progressive Neoplasia Development in Mouse Stomach. Gastroenterology. 2018 12; 155(6):1852-1867. PMID: 30195448.
    Citations:    Fields:    Translation:AnimalsCells
  3. Desai A, Alves-Bezerra M, Li Y, Ozdemir C, Bare CJ, Li Y, Hagen SJ, Cohen DE. Regulation of fatty acid trafficking in liver by thioesterase superfamily member 1. J Lipid Res. 2018 02; 59(2):368-379. PMID: 29208699.
    Citations:    Fields:    
  4. Palmer CJ, Bruckner RJ, Paulo JA, Kazak L, Long JZ, Mina AI, Deng Z, LeClair KB, Hall JA, Hong S, Zushin PH, Smith KL, Gygi SP, Hagen S, Cohen DE, Banks AS. Cdkal1, a type 2 diabetes susceptibility gene, regulates mitochondrial function in adipose tissue. Mol Metab. 2017 10; 6(10):1212-1225. PMID: 29031721.
    Citations:    
  5. Hagen SJ. Non-canonical functions of claudin proteins: Beyond the regulation of cell-cell adhesions. Tissue Barriers. 2017 04 03; 5(2):e1327839. PMID: 28548895.
    Citations: 2     Fields:    Translation:Humans
  6. Okada K, LeClair KB, Zhang Y, Li Y, Ozdemir C, Krisko TI, Hagen SJ, Betensky RA, Banks AS, Cohen DE. Thioesterase superfamily member 1 suppresses cold thermogenesis by limiting the oxidation of lipid droplet-derived fatty acids in brown adipose tissue. Mol Metab. 2016 May; 5(5):340-351. PMID: 27110486.
    Citations: 4     Fields:    
  7. Caron TJ, Scott KE, Fox JG, Hagen SJ. Tight junction disruption: Helicobacter pylori and dysregulation of the gastric mucosal barrier. World J Gastroenterol. 2015 Oct 28; 21(40):11411-27. PMID: 26523106.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  8. Adolph TE, Tomczak MF, Niederreiter L, Ko HJ, Böck J, Martinez-Naves E, Glickman JN, Tschurtschenthaler M, Hartwig J, Hosomi S, Flak MB, Cusick JL, Kohno K, Iwawaki T, Billmann-Born S, Raine T, Bharti R, Lucius R, Kweon MN, Marciniak SJ, Choi A, Hagen SJ, Schreiber S, Rosenstiel P, Kaser A, Blumberg RS. Paneth cells as a site of origin for intestinal inflammation. Nature. 2013 Nov 14; 503(7475):272-6. PMID: 24089213.
    Citations: 160     Fields:    Translation:AnimalsCells
  9. Kang HW, Ozdemir C, Kawano Y, LeClair KB, Vernochet C, Kahn CR, Hagen SJ, Cohen DE. Thioesterase superfamily member 2/Acyl-CoA thioesterase 13 (Them2/Acot13) regulates adaptive thermogenesis in mice. J Biol Chem. 2013 Nov 15; 288(46):33376-86. PMID: 24072708.
    Citations: 9     Fields:    Translation:AnimalsCells
  10. Seo JH, Fox JG, Peek RM, Hagen SJ. N-methyl D-aspartate channels link ammonia and epithelial cell death mechanisms in Helicobacter pylori Infection. Gastroenterology. 2011 Dec; 141(6):2064-75. PMID: 21925124.
    Citations: 4     Fields:    Translation:AnimalsCells
  11. Song P, Groos S, Riederer B, Feng Z, Krabbenhöft A, Manns MP, Smolka A, Hagen SJ, Neusch C, Seidler U. Kir4.1 channel expression is essential for parietal cell control of acid secretion. J Biol Chem. 2011 Apr 22; 286(16):14120-8. PMID: 21367857.
    Citations: 7     Fields:    Translation:AnimalsCells
  12. Shanahan MT, Vidrich A, Shirafuji Y, Dubois CL, Henschen-Edman A, Hagen SJ, Cohn SM, Ouellette AJ. Elevated expression of Paneth cell CRS4C in ileitis-prone SAMP1/YitFc mice: regional distribution, subcellular localization, and mechanism of action. J Biol Chem. 2010 Mar 05; 285(10):7493-504. PMID: 20056603.
    Citations: 8     Fields:    Translation:AnimalsCells
  13. Kang HW, Ribich S, Kim BW, Hagen SJ, Bianco AC, Cohen DE. Mice lacking Pctp /StarD2 exhibit increased adaptive thermogenesis and enlarged mitochondria in brown adipose tissue. J Lipid Res. 2009 Nov; 50(11):2212-21. PMID: 19502644.
    Citations: 13     Fields:    Translation:AnimalsCells
  14. Hagen SJ, Ohtani M, Zhou JR, Taylor NS, Rickman BH, Blackburn GL, Fox JG. Inflammation and foveolar hyperplasia are reduced by supplemental dietary glutamine during Helicobacter pylori infection in mice. J Nutr. 2009 May; 139(5):912-8. PMID: 19261732.
    Citations: 7     Fields:    Translation:AnimalsCells
  15. Hayashi S, Nakamura E, Kubo Y, Takahashi N, Yamaguchi A, Matsui H, Hagen SJ, Takeuchi K. Impairment by allyl isothiocyanate of gastric epithelial wound repair through inhibition of ion transporters. J Physiol Pharmacol. 2008 Dec; 59(4):691-706. PMID: 19212004.
    Citations: 5     Fields:    Translation:AnimalsCells
  16. Tashima K, Zhang S, Ragasa R, Nakamura E, Seo JH, Muvaffak A, Hagen SJ. Hepatocyte growth factor regulates the development of highly pure cultured chief cells from rat stomach by stimulating chief cell proliferation in vitro. Am J Physiol Gastrointest Liver Physiol. 2009 Feb; 296(2):G319-29. PMID: 19023030.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  17. Hagen SJ, Yang DX, Tashima K, Taylor NS, Fox JG. Epithelial cell expression of BCL-2 family proteins predicts mechanisms that regulate Helicobacter pylori-induced pathology in the mouse stomach. Lab Invest. 2008 Nov; 88(11):1227-44. PMID: 18779780.
    Citations: 3     Fields:    Translation:AnimalsCells
  18. Kaufhold MA, Krabbenhöft A, Song P, Engelhardt R, Riederer B, Fährmann M, Klöcker N, Beil W, Manns M, Hagen SJ, Seidler U. Localization, trafficking, and significance for acid secretion of parietal cell Kir4.1 and KCNQ1 K+ channels. Gastroenterology. 2008 Apr; 134(4):1058-69. PMID: 18395087.
    Citations: 16     Fields:    Translation:AnimalsCells
  19. Ragasa R, Nakamura E, Marrone L, Yanaka S, Hayashi S, Takeuchi K, Hagen SJ. Isothiocyanate inhibits restitution and wound repair after injury in the stomach: ex vivo and in vitro studies. J Pharmacol Exp Ther. 2007 Oct; 323(1):1-9. PMID: 17609422.
    Citations: 2     Fields:    Translation:AnimalsCells
  20. Hagen SJ, Morrison SW, Law CS, Yang DX. Restitution of the bullfrog gastric mucosa is dependent on a DIDS-inhibitable pathway not related to HCO3- ion transport. Am J Physiol Gastrointest Liver Physiol. 2004 Apr; 286(4):G596-605. PMID: 14604862.
    Citations: 4     Fields:    Translation:AnimalsCells
  21. Nakamura E, Hagen SJ. Role of glutamine and arginase in protection against ammonia-induced cell death in gastric epithelial cells. Am J Physiol Gastrointest Liver Physiol. 2002 Dec; 283(6):G1264-75. PMID: 12388179.
    Citations: 12     Fields:    Translation:AnimalsCells
  22. He D, Sougioultzis S, Hagen S, Liu J, Keates S, Keates AC, Pothoulakis C, Lamont JT. Clostridium difficile toxin A triggers human colonocyte IL-8 release via mitochondrial oxygen radical generation. Gastroenterology. 2002 Apr; 122(4):1048-57. PMID: 11910356.
    Citations: 36     Fields:    Translation:HumansCells
  23. Abdul-Ghaffar Al-Shaibani TA, Hagen SJ. Regulation of acid secretion and paracellular permeability by F-actin in the bullfrog, Rana catesbeiana. Am J Physiol Gastrointest Liver Physiol. 2002 Mar; 282(3):G519-26. PMID: 11842002.
    Citations: 1     Fields:    Translation:AnimalsCells
  24. Ayabe T, Satchell DP, Pesendorfer P, Tanabe H, Wilson CL, Hagen SJ, Ouellette AJ. Activation of Paneth cell alpha-defensins in mouse small intestine. J Biol Chem. 2002 Feb 15; 277(7):5219-28. PMID: 11733520.
    Citations: 57     Fields:    Translation:AnimalsCells
  25. Cheng AM, Morrison SW, Yang DX, Hagen SJ. Energy dependence of restitution in the gastric mucosa. Am J Physiol Cell Physiol. 2001 Aug; 281(2):C430-8. PMID: 11443042.
    Citations: 6     Fields:    Translation:AnimalsCells
  26. Ouellette AJ, Satchell DP, Hsieh MM, Hagen SJ, Selsted ME. Characterization of luminal paneth cell alpha-defensins in mouse small intestine. Attenuated antimicrobial activities of peptides with truncated amino termini. J Biol Chem. 2000 Oct 27; 275(43):33969-73. PMID: 10942762.
    Citations: 17     Fields:    Translation:AnimalsCells
  27. Hagen SJ, Wu H, Morrison SW. NH(4)Cl inhibition of acid secretion: possible involvement of an apical K(+) channel in bullfrog oxyntic cells. Am J Physiol Gastrointest Liver Physiol. 2000 Aug; 279(2):G400-10. PMID: 10915650.
    Citations: 4     Fields:    Translation:AnimalsCells
  28. Saubermann LJ, Beck P, De Jong YP, Pitman RS, Ryan MS, Kim HS, Exley M, Snapper S, Balk SP, Hagen SJ, Kanauchi O, Motoki K, Sakai T, Terhorst C, Koezuka Y, Podolsky DK, Blumberg RS. Activation of natural killer T cells by alpha-galactosylceramide in the presence of CD1d provides protection against colitis in mice. Gastroenterology. 2000 Jul; 119(1):119-28. PMID: 10889161.
    Citations: 48     Fields:    Translation:AnimalsCells
  29. He D, Hagen SJ, Pothoulakis C, Chen M, Medina ND, Warny M, LaMont JT. Clostridium difficile toxin A causes early damage to mitochondria in cultured cells. Gastroenterology. 2000 Jul; 119(1):139-50. PMID: 10889163.
    Citations: 25     Fields:    Translation:AnimalsCells
  30. Esteves MI, Schrenzel MD, Marini RP, Taylor NS, Xu S, Hagen S, Feng Y, Shen Z, Fox JG. Helicobacter pylori gastritis in cats with long-term natural infection as a model of human disease. Am J Pathol. 2000 Feb; 156(2):709-21. PMID: 10666399.
    Citations: 4     Fields:    Translation:AnimalsCells
  31. Unno N, Menconi MJ, Smith M, Hagen SJ, Brown DA, Aguirre DE, Fink MP. Acidic conditions ameliorate both adenosine triphosphate depletion and the development of hyperpermeability in cultured Caco-2BBe enterocytic monolayers subjected to metabolic inhibition. Surgery. 1997 Jun; 121(6):668-80. PMID: 9186468.
    Citations: 2     Fields:    Translation:HumansCells
  32. Hagen SJ, Takahashi S, Jansons R. Role of vacuolation in the death of gastric epithelial cells. Am J Physiol. 1997 Jan; 272(1 Pt 1):C48-58. PMID: 9038810.
    Citations: 9     Fields:    Translation:AnimalsCells
  33. Unno N, Menconi MJ, Salzman AL, Smith M, Hagen S, Ge Y, Ezzell RM, Fink MP. Hyperpermeability and ATP depletion induced by chronic hypoxia or glycolytic inhibition in Caco-2BBe monolayers. Am J Physiol. 1996 Jun; 270(6 Pt 1):G1010-21. PMID: 8764209.
    Citations: 13     Fields:    Translation:HumansCells
  34. Crawford JM, Möckel GM, Crawford AR, Hagen SJ, Hatch VC, Barnes S, Godleski JJ, Carey MC. Imaging biliary lipid secretion in the rat: ultrastructural evidence for vesiculation of the hepatocyte canalicular membrane. J Lipid Res. 1995 Oct; 36(10):2147-63. PMID: 8576641.
    Citations: 19     Fields:    Translation:AnimalsCells
  35. Hagen SJ, Yanaka A, Jansons R. Localization of brush border cytoskeletal proteins in gastric oxynticopeptic cells from the bullfrog Rana catesbeiana. Cell Tissue Res. 1994 Feb; 275(2):255-67. PMID: 8111837.
    Citations:    Fields:    Translation:AnimalsCells
  36. Hagen SJ, Trier JS, Dambrauskas R. Exposure of the rat small intestine to raw kidney beans results in reorganization of absorptive cell microvilli. Gastroenterology. 1994 Jan; 106(1):73-84. PMID: 8276211.
    Citations: 5     Fields:    Translation:AnimalsCells
  37. Ouellette AJ, Frederick D, Hagen SJ, Katz JD. Class II antigen-associated invariant chain mRNA in mouse small intestine. Biochem Biophys Res Commun. 1991 Sep 30; 179(3):1642-8. PMID: 1718272.
    Citations:    Fields:    Translation:AnimalsCells
  38. Bleicher PA, Balk SP, Hagen SJ, Blumberg RS, Flotte TJ, Terhorst C. Expression of murine CD1 on gastrointestinal epithelium. Science. 1990 Nov 02; 250(4981):679-82. PMID: 1700477.
    Citations: 47     Fields:    Translation:AnimalsCells
  39. Hagen SJ. Lowicryl embedding of gastrointestinal tissues. J Electron Microsc Tech. 1990 Sep; 16(1):37-44. PMID: 2213230.
    Citations: 1     Fields:    Translation:Animals
  40. Trier JS, Allan CH, Abrahamson DR, Hagen SJ. Epithelial basement membrane of mouse jejunum. Evidence for laminin turnover along the entire crypt-villus axis. J Clin Invest. 1990 Jul; 86(1):87-95. PMID: 2195064.
    Citations: 11     Fields:    Translation:Animals
  41. Weinman MD, Allan CH, Trier JS, Hagen SJ. Repair of microvilli in the rat small intestine after damage with lectins contained in the red kidney bean. Gastroenterology. 1989 Nov; 97(5):1193-204. PMID: 2792657.
    Citations: 9     Fields:    Translation:AnimalsCells
  42. Hagen SJ, Trier JS. Immunocytochemical localization of actin in epithelial cells of rat small intestine by light and electron microscopy. J Histochem Cytochem. 1988 Jul; 36(7):717-27. PMID: 3290330.
    Citations: 10     Fields:    Translation:AnimalsCells
  43. Hagen SJ, Allan CH, Trier JS. Demonstration of microtubules in the terminal web of mature absorptive cells from the small intestine of the rat. Cell Tissue Res. 1987 Jun; 248(3):709-11. PMID: 3607856.
    Citations: 6     Fields:    Translation:AnimalsCells
  44. Bjorkman DJ, Allan CH, Hagen SJ, Trier JS. Structural features of absorptive cell and microvillus membrane preparations from rat small intestine. Gastroenterology. 1986 Dec; 91(6):1401-14. PMID: 3533700.
    Citations: 9     Fields:    Translation:AnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.