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Susan James Hagen, Ph.D.


Available: 01/10/22, Expires: 03/01/24

Them1, or acyl-CoA thioesterase, regulates metabolism by forming puncta in cells that change to a diffuse pattern after stimulation by cold exposure or after eating a high fat diet. The aim of this project would be to characterize the nature of puncta by using biophysics and cell/molecular biology methods. Biomolecular condensates form by liquid-liquid phase transition in cells by increasing concentration, temperature, pH, or by other properties of the protein. The student would thus use use purified Them1 and microscopy techniques to determine how Them1 phase separates into biomolecular condensates and then test the learned principles in cultured cells. The student would do hands-on bench experiments and learn to use the confocal microsocope. They would design experiments after reading papers, present the design to the PI and senior lab manager, carry-out experiments with help/supervision if needed, analyze data, present data at a weekly lab meeting, (if successful) present data at a National/International scientific meeting and write this section/co-author a paper for publication. Some wet bench skills in advance including pipetting and designing experiments would be helpful.

Role of Ammonia and H. Pylori Vacuolating Cytotoxin in Restitution
Full Time/Year Long, 07/01/98 - 06/30/99

The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01DK103046 (COHEN, DAVID E. ;HAGEN, SUSAN J;ORTLUND, ERIC A) Jul 5, 2015 - Jun 30, 2024
    Them1-Mediated Metabolic Regulation and Pathogenic Role in NAFLD
    Role: Multi-PI
  2. S10OD019988 (HAGEN, SUSAN J) Apr 1, 2015 - Mar 31, 2016
    Wohlwend High Pressure Freezer for the BIDMC Electron Microscopy Core
    Role: Principal Investigator
  3. S10RR017927 (HAGEN, SUSAN J) May 1, 2006 - Apr 30, 2007
    Confocal Microscope for the BIDMC Imaging Core Facility
    Role: Principal Investigator
  4. R55DK044287 (HAGEN, SUSAN J) Sep 30, 1991 - Sep 29, 1993
    Role: Principal Investigator
  5. P30DK034854 (LENCER, WAYNE I) Sep 30, 1984 - Mar 31, 2026
    Integrated Epithelial and Muscosal Biology
    Role: Co-Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.