Harvard Catalyst Profiles

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Nicholas Stephanopoulos, Ph.D.


Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Yuan T, Shao Y, Zhou X, Liu Q, Zhu Z, Zhou B, Dong Y, Stephanopoulos N, Gui S, Yan H, Liu D. Highly Permeable DNA Supramolecular Hydrogel Promotes Neurogenesis and Functional Recovery after Completely Transected Spinal Cord Injury. Adv Mater. 2021 Sep; 33(35):e2102428. PMID: 34296471.
    Citations:    Fields:    
  2. Henry SJW, Stephanopoulos N. Functionalizing DNA nanostructures for therapeutic applications. Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2021 May 19; e1729. PMID: 34008347.
    Citations: 1     Fields:    
  3. Buchberger A, Saini H, Eliato KR, Zare A, Merkley R, Xu Y, Bernal J, Ros R, Nikkhah M, Stephanopoulos N. Reversible Control of Gelatin Hydrogel Stiffness by Using DNA Crosslinkers*. Chembiochem. 2021 May 14; 22(10):1755-1760. PMID: 33484601.
    Citations:    Fields:    
  4. Simmons CR, MacCulloch T, Zhang F, Liu Y, Stephanopoulos N, Yan H. A Self-Assembled Rhombohedral DNA Crystal Scaffold with Tunable Cavity Sizes and High-Resolution Structural Detail. Angew Chem Int Ed Engl. 2020 10 12; 59(42):18619-18626. PMID: 32533629.
    Citations:    Fields:    
  5. Xu Y, Jiang S, Simmons CR, Narayanan RP, Zhang F, Aziz AM, Yan H, Stephanopoulos N. Correction to Tunable Nanoscale Cages from Self-Assembling DNA and Protein Building Blocks. ACS Nano. 2020 06 23; 14(6):7673. PMID: 32420729.
    Citations:    Fields:    
  6. Fumasi FM, Stephanopoulos N, Holloway JL. Reversible control of biomaterial properties for dynamically tuning cell behavior. J Appl Polym Sci. 2020 Jul 05; 137(25). PMID: 34054139.
  7. Buchberger A, Simmons CR, Fahmi NE, Freeman R, Stephanopoulos N. Hierarchical Assembly of Nucleic Acid/Coiled-Coil Peptide Nanostructures. J Am Chem Soc. 2020 01 22; 142(3):1406-1416. PMID: 31820959.
    Citations: 4     Fields:    
  8. Mahatmanto T, Azizah I, Buchberger A, Stephanopoulos N. Progress toward sourcing plants for new bioconjugation tools: a screening evaluation of a model peptide ligase using a synthetic precursor. 3 Biotech. 2019 Dec; 9(12):442. PMID: 31763120.
  9. Stephanopoulos N. Strategies for Stabilizing DNA Nanostructures to Biological Conditions. Chembiochem. 2019 09 02; 20(17):2191-2197. PMID: 30875443.
    Citations: 5     Fields:    
  10. Stephanopoulos N. Peptide-Oligonucleotide Hybrid Molecules for Bioactive Nanomaterials. Bioconjug Chem. 2019 07 17; 30(7):1915-1922. PMID: 31082220.
    Citations: 7     Fields:    Translation:HumansAnimals
  11. Xu Y, Jiang S, Simmons CR, Narayanan RP, Zhang F, Aziz AM, Yan H, Stephanopoulos N. Tunable Nanoscale Cages from Self-Assembling DNA and Protein Building Blocks. ACS Nano. 2019 03 26; 13(3):3545-3554. PMID: 30835439.
    Citations: 6     Fields:    Translation:Humans
  12. Stelson AC, Liu M, Little CAE, Long CJ, Orloff ND, Stephanopoulos N, Booth JC. Label-free detection of conformational changes in switchable DNA nanostructures with microwave microfluidics. Nat Commun. 2019 03 12; 10(1):1174. PMID: 30862776.
    Citations: 1     Fields:    Translation:Cells
  13. MacCulloch T, Buchberger A, Stephanopoulos N. Emerging applications of peptide-oligonucleotide conjugates: bioactive scaffolds, self-assembling systems, and hybrid nanomaterials. Org Biomol Chem. 2019 02 13; 17(7):1668-1682. PMID: 30483688.
    Citations: 4     Fields:    
  14. Freeman R, Han M, Álvarez Z, Lewis JA, Wester JR, Stephanopoulos N, McClendon MT, Lynsky C, Godbe JM, Sangji H, Luijten E, Stupp SI. Reversible self-assembly of superstructured networks. Science. 2018 11 16; 362(6416):808-813. PMID: 30287619.
    Citations: 32     Fields:    
  15. Liu M, Jiang S, Loza O, Fahmi NE, Šulc P, Stephanopoulos N. Rapid Photoactuation of a DNA Nanostructure using an Internal Photocaged Trigger Strand. Angew Chem Int Ed Engl. 2018 07 20; 57(30):9341-9345. PMID: 29790232.
    Citations: 5     Fields:    Translation:Cells
  16. Greene JJ, McClendon MT, Stephanopoulos N, Álvarez Z, Stupp SI, Richter CP. Electrophysiological assessment of a peptide amphiphile nanofiber nerve graft for facial nerve repair. J Tissue Eng Regen Med. 2018 06; 12(6):1389-1401. PMID: 29701919.
    Citations: 4     Fields:    Translation:AnimalsCells
  17. Matsuoka AJ, Sayed ZA, Stephanopoulos N, Berns EJ, Wadhwani AR, Morrissey ZD, Chadly DM, Kobayashi S, Edelbrock AN, Mashimo T, Miller CA, McGuire TL, Stupp SI, Kessler JA. Creating a stem cell niche in the inner ear using self-assembling peptide amphiphiles. PLoS One. 2017; 12(12):e0190150. PMID: 29284013.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  18. Simmons CR, Zhang F, MacCulloch T, Fahmi N, Stephanopoulos N, Liu Y, Seeman NC, Yan H. Tuning the Cavity Size and Chirality of Self-Assembling 3D DNA Crystals. J Am Chem Soc. 2017 08 16; 139(32):11254-11260. PMID: 28731332.
    Citations: 6     Fields:    Translation:Cells
  19. Freeman R, Stephanopoulos N, Álvarez Z, Lewis JA, Sur S, Serrano CM, Boekhoven J, Lee SS, Stupp SI. Instructing cells with programmable peptide DNA hybrids. Nat Commun. 2017 07 10; 8:15982. PMID: 28691701.
    Citations: 10     Fields:    Translation:AnimalsCells
  20. Varun D, Srinivasan GR, Tsai YH, Kim HJ, Cutts J, Petty F, Merkley R, Stephanopoulos N, Dolezalova D, Marsala M, Brafman DA. A robust vitronectin-derived peptide for the scalable long-term expansion and neuronal differentiation of human pluripotent stem cell (hPSC)-derived neural progenitor cells (hNPCs). Acta Biomater. 2017 01 15; 48:120-130. PMID: 27989923.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  21. Stephanopoulos N, Freeman R, North HA, Sur S, Jeong SJ, Tantakitti F, Kessler JA, Stupp SI. Bioactive DNA-peptide nanotubes enhance the differentiation of neural stem cells into neurons. . 2015 Jan 14; 15(1):603-9. PMID: 25546084.
    Citations: 19     Translation:AnimalsCells
  22. Rubert Pérez CM, Stephanopoulos N, Sur S, Lee SS, Newcomb C, Stupp SI. The powerful functions of peptide-based bioactive matrices for regenerative medicine. Ann Biomed Eng. 2015 Mar; 43(3):501-14. PMID: 25366903.
    Citations: 31     Fields:    Translation:HumansAnimals
  23. Li A, Hokugo A, Yalom A, Berns EJ, Stephanopoulos N, McClendon MT, Segovia LA, Spigelman I, Stupp SI, Jarrahy R. A bioengineered peripheral nerve construct using aligned peptide amphiphile nanofibers. Biomaterials. 2014 Oct; 35(31):8780-8790. PMID: 25064803.
    Citations: 27     Fields:    Translation:AnimalsCells
  24. Sack JT, Stephanopoulos N, Austin DC, Francis MB, Trimmer JS. Antibody-guided photoablation of voltage-gated potassium currents. J Gen Physiol. 2013 Sep; 142(3):315-24. PMID: 23940262.
    Citations: 3     Fields:    Translation:Animals
  25. Stephanopoulos N, Ortony JH, Stupp SI. Self-Assembly for the Synthesis of Functional Biomaterials. Acta Mater. 2013 Feb 01; 61(3):912-930. PMID: 23457423.
    Citations: 34     
  26. Stephanopoulos N, Francis MB. Choosing an effective protein bioconjugation strategy. Nat Chem Biol. 2011 Nov 15; 7(12):876-84. PMID: 22086289.
    Citations: 124     Fields:    
  27. Stephanopoulos N, Tong GJ, Hsiao SC, Francis MB. Dual-surface modified virus capsids for targeted delivery of photodynamic agents to cancer cells. ACS Nano. 2010 Oct 26; 4(10):6014-20. PMID: 20863095.
    Citations: 56     Fields:    Translation:HumansCells
  28. Holder PG, Finley DT, Stephanopoulos N, Walton R, Clark DS, Francis MB. Dramatic thermal stability of virus-polymer conjugates in hydrophobic solvents. Langmuir. 2010 Nov 16; 26(22):17383-8. PMID: 20964388.
    Citations: 6     Fields:    Translation:Cells
  29. Stephanopoulos N, Liu M, Tong GJ, Li Z, Liu Y, Yan H, Francis MB. Immobilization and one-dimensional arrangement of virus capsids with nanoscale precision using DNA origami. . 2010 Jul 14; 10(7):2714-20. PMID: 20575574.
    Citations: 25     Translation:Cells
  30. Miller RA, Stephanopoulos N, McFarland JM, Rosko AS, Geissler PL, Francis MB. Impact of assembly state on the defect tolerance of TMV-based light harvesting arrays. J Am Chem Soc. 2010 May 05; 132(17):6068-74. PMID: 20392093.
    Citations: 8     Fields:    Translation:Cells
  31. Stephanopoulos N, Carrico ZM, Francis MB. Nanoscale integration of sensitizing chromophores and porphyrins with bacteriophage MS2. Angew Chem Int Ed Engl. 2009; 48(50):9498-502. PMID: 19921726.
    Citations: 18     Fields:    Translation:Cells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.