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Raul Hernandes Bortolin, Ph.D., Pharm.D.


Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. de Melo TR, de Souza KSC, Ururahy MAG, Bortolin RH, Bezerra JF, de Oliveira Galvão MF, Hirata RDC, Hirata MH, Arrais RF, Almeida MDG, de Rezende AA, Silbiger VN. Toll-like receptor inflammatory cascade and the development of diabetic kidney disease in children and adolescents with type 1 diabetes. J Paediatr Child Health. 2022 Jun; 58(6):996-1000. PMID: 35006634.
    Citations:    Fields:    
  2. Cabral B, Bortolin RH, Gonçalves TAF, Maciel PMP, de Arruda AV, de Carvalho TG, Abboud KY, Alves JSF, Cordeiro LMC, de Medeiros IA, de Rezende AA, Zucolotto SM. Hypoglycemic and Vasorelaxant Effect of Passiflora edulis Fruit Peel By-Product. Plant Foods Hum Nutr. 2021 Dec; 76(4):466-471. PMID: 34581915.
    Citations:    Fields:    Translation:Animals
  3. Castelli EC, de Castro MV, Naslavsky MS, Scliar MO, Silva NSB, Andrade HS, Souza AS, Pereira RN, Castro CFB, Mendes-Junior CT, Meyer D, Nunes K, Matos LRB, Silva MVR, Wang JYT, Esposito J, Coria VR, Bortolin RH, Hirata MH, Magawa JY, Cunha-Neto E, Coelho V, Santos KS, Marin MLC, Kalil J, Mitne-Neto M, Maciel RMB, Passos-Bueno MR, Zatz M. MHC Variants Associated With Symptomatic Versus Asymptomatic SARS-CoV-2 Infection in Highly Exposed Individuals. Front Immunol. 2021; 12:742881. PMID: 34650566.
    Citations: 3     Fields:    Translation:HumansCells
  4. Los B, Borges JB, Oliveira VF, Freitas RC, Dagli-Hernandez C, Bortolin RH, Gonçalves RM, Faludi AA, Rodrigues AC, Bastos GM, Jannes CE, Pereira AC, Hirata RD, Hirata MH. Functional analysis of PCSK9 3'UTR variants and mRNA-miRNA interactions in patients with familial hypercholesterolemia. Epigenomics. 2021 05; 13(10):779-791. PMID: 33899508.
    Citations: 1     Fields:    Translation:HumansCells
  5. Cerda A, Bortolin RH, Manriquez V, Salazar L, Zambrano T, Fajardo CM, Hirata MH, Hirata RDC. Effect of statins on lipid metabolism-related microRNA expression in HepG2 cells. Pharmacol Rep. 2021 Jun; 73(3):868-880. PMID: 33721286.
    Citations: 3     Fields:    Translation:HumansCells
  6. Braga AA, Bortolin RH, Graciano-Saldarriaga ME, Hirata TD, Cerda A, de Freitas RC, Lin-Wang HT, Borges JB, França JI, Masi LN, Curi R, Pithon-Curi TC, Sampaio MF, Castro LR, Bastos GM, Hirata RD, Hirata MH. High serum miR-421 is associated with metabolic dysregulation and inflammation in patients with metabolic syndrome. Epigenomics. 2021 03; 13(6):423-436. PMID: 33678000.
    Citations: 4     Fields:    Translation:Humans
  7. Mori AA, Castro LR, Bortolin RH, Bastos GM, Oliveira VF, Ferreira GM, Hirata TDC, Fajardo CM, Sampaio MF, Moreira DAR, Pachón-Mateos JC, Correia EB, Sousa AGMR, Brión M, Carracedo A, Hirata RDC, Hirata MH. Association of variants in MYH7, MYBPC3 and TNNT2 with sudden cardiac death-related risk factors in Brazilian patients with hypertrophic cardiomyopathy. Forensic Sci Int Genet. 2021 05; 52:102478. PMID: 33588347.
    Citations: 3     Fields:    Translation:Humans
  8. Dagli-Hernandez C, de Freitas RCC, Marçal EDSR, Gonçalves RM, Faludi AA, Borges JB, Bastos GM, Los B, Mori AA, Bortolin RH, Ferreira GM, de Oliveira VF, Hirata TDC, Hirata MH, Hirata RDC. Late response to rosuvastatin and statin-related myalgia due to SLCO1B1, SLCO1B3, ABCB11, and CYP3A5 variants in a patient with Familial Hypercholesterolemia: a case report. Ann Transl Med. 2021 Jan; 9(1):76. PMID: 33553369.
    Citations: 3     
  9. Freitas RCC, Bortolin RH, Genvigir FDV, Bonezi V, Hirata TDC, Felipe CR, Tedesco-Silva H, Medina-Pestana JO, Cerda A, Doi SQ, Hirata MH, Hirata RDC. Differentially expressed urinary exo-miRs and clinical outcomes in kidney recipients on short-term tacrolimus therapy: a pilot study. Epigenomics. 2020 11; 12(22):2019-2034. PMID: 33275448.
    Citations: 2     Fields:    Translation:HumansCells
  10. Borges JB, Oliveira VF, Ferreira GM, Los B, Barbosa TKAA, Marçal EDSR, Dagli-Hernandez C, de Freitas RCC, Bortolin RH, Mori AA, Hirata TDC, Nakaya HTI, Bastos GM, Thurow HS, Gonçalves RM, Araujo DB, Zatz HP, Bertolami A, Faludi AA, Bertolami MC, Sousa AGMR, França JÍD, Jannes CE, Pereira ADC, Nakazone MA, Souza DRS, Carmo TS, Sampaio MF, Gorjão R, Pithon-Curi TC, Moriel P, Silbiger VN, Luchessi AD, de Araújo JNG, Naslavsky MS, Wang JYT, Kronenberger T, Cerda A, Lin-Wang HT, Garofalo AR, Fajardo CM, Hirata RDC, Hirata MH. Genomics, epigenomics and pharmacogenomics of familial hypercholesterolemia (FHBGEP): A study protocol. Res Social Adm Pharm. 2021 07; 17(7):1347-1355. PMID: 33129683.
    Citations: 1     Fields:    Translation:Humans
  11. Medeiros JFP, de Oliveira Borges MV, Soares AA, Dos Santos JC, de Oliveira ABB, da Costa CHB, Cruz MS, Bortolin RH, de Freitas RCC, Dantas PMS, Hirata MH, Silbiger VN, Luchessi AD. The impact of vitamin D supplementation on VDR gene expression and body composition in monozygotic twins: randomized controlled trial. Sci Rep. 2020 07 20; 10(1):11943. PMID: 32686744.
    Citations: 4     Fields:    Translation:Humans
  12. Bertol BC, de Araújo JNG, Sadissou IA, Sonon P, Dias FC, Bortolin RH, de Figueiredo-Feitosa NL, de Freitas LCC, de Miranda Henrique Tarrapp SR, de Oliveira Ramos CC, Luchessi AD, de Freitas JCOC, Maciel LMZ, Silbiger VN, Donadi EA. Plasma levels of soluble HLA-G and cytokines in papillary thyroid carcinoma before and after thyroidectomy. Int J Clin Pract. 2020 Oct; 74(10):e13585. PMID: 32534476.
    Citations: 5     Fields:    Translation:Humans
  13. Kaid C, Assoni A, Marçola M, Semedo-Kuriki P, Bortolin RH, Carvalho VM, Okamoto OK. Proteome and miRNome profiling of microvesicles derived from medulloblastoma cell lines with stem-like properties reveals biomarkers of poor prognosis. Brain Res. 2020 03 01; 1730:146646. PMID: 31917138.
    Citations: 5     Fields:    Translation:HumansCells
  14. Bezerra JF, Silva HPVD, Bortolin RH, Luchessi AD, Ururahy MAG, Loureiro MB, Gil-da-Silva-Lopes VL, Almeida MDG, Amaral VSD, Rezende AA. IRF6 polymorphisms in Brazilian patients with non-syndromic cleft lip with or without palate. Braz J Otorhinolaryngol. 2020 Nov - Dec; 86(6):696-702. PMID: 31495697.
    Citations: 1     Fields:    Translation:Humans
  15. Carvalho FMC, Lima VCO, Costa IS, Luz ABS, Ladd FVL, Serquiz AC, Bortolin RH, Silbiger VN, Maciel BLL, Santos EA, Morais AHA. Anti-TNF-a Agent Tamarind Kunitz Trypsin Inhibitor Improves Lipid Profile of Wistar Rats Presenting Dyslipidemia and Diet-induced Obesity Regardless of PPAR-? Induction. Nutrients. 2019 Feb 27; 11(3). PMID: 30818882.
    Citations: 6     Fields:    Translation:Animals
  16. de Oliveira AR, da Silva FS, Bortolin RH, Marques DEDS, Ramos GV, Marqueti RC, da Silva NB, Medeiros KCP, Corrêa MA, Lima JPMS, de Rezende AA, Ackermann PW, Abreu BJ, de Brito Vieira WH. Effect of photobiomodulation and exercise on early remodeling of the Achilles tendon in streptozotocin-induced diabetic rats. PLoS One. 2019; 14(2):e0211643. PMID: 30716140.
    Citations: 1     Fields:    Translation:AnimalsCells
  17. Costa IS, Medeiros AF, Carvalho FMC, Lima VCO, Serquiz RP, Serquiz AC, Silbiger VN, Bortolin RH, Maciel BLL, Santos EA, Morais AHA. Satietogenic Protein from Tamarind Seeds Decreases Food Intake, Leptin Plasma and CCK-1r Gene Expression in Obese Wistar Rats. Obes Facts. 2018; 11(6):440-453. PMID: 30537704.
    Citations: 7     Fields:    Translation:AnimalsCells
  18. Pereira ASBF, Brito GAC, Lima MLS, Silva Júnior AAD, Silva EDS, de Rezende AA, Bortolin RH, Galvan M, Pirih FQ, Araújo Júnior RF, Medeiros CACX, Guerra GCB, Araújo AA. Metformin Hydrochloride-Loaded PLGA Nanoparticle in Periodontal Disease Experimental Model Using Diabetic Rats. Int J Mol Sci. 2018 Nov 06; 19(11). PMID: 30404181.
    Citations: 10     Fields:    Translation:Animals
  19. Souza KSC, Gomes IS, Oliveira YMDC, Loureiro MB, Silva HPVD, Melo TR, Santos MGD, Bortolin RH, Maciel Neto JJ, Arrais RF, Almeida MDG, Ururahy MAG, Rezende AA. Albuminuria and low bone mineral density in paediatric patients with type 1 diabetes. J Paediatr Child Health. 2019 Apr; 55(4):411-415. PMID: 30218466.
    Citations:    Fields:    Translation:HumansPHPublic Health
  20. Souza KSC, Ururahy MAG, Oliveira YMDC, Loureiro MB, Silva HPVD, Bortolin RH, Luchessi AD, Arrais RF, Hirata RDC, Almeida MDG, Hirata MH, Rezende AA. The low-density lipoprotein receptor-related protein 5 (LRP5) 4037C>T polymorphism: candidate for susceptibility to type 1 diabetes mellitus. Arch Endocrinol Metab. 2018 Aug; 62(4):480-484. PMID: 30304114.
    Citations:    Fields:    Translation:Humans
  21. Luz ABS, Dos Santos Figueredo JB, Salviano BDPD, Aguiar AJFC, Pinheiro LGSD, Krause MFD, da Silva Camillo C, Ladd FVL, Bortolin RH, Silbiger VN, Maciel BLL, de Araújo Morais AH. Adipocytes and intestinal epithelium dysfunctions linking obesity to inflammation induced by high glycemic index pellet-diet in Wistar rats. Biosci Rep. 2018 06 29; 38(3). PMID: 29950343.
    Citations: 8     Fields:    Translation:AnimalsCellsPHPublic Health
  22. Santos JCD, Cruz MS, Bortolin RH, Oliveira KM, Araújo JNG, Duarte VHR, Silva AMGD, Santos ICCD, Dantas JMO, Paiva MSMO, Rezende AA, Hirata MH, Hirata RDC, Luchessi AD, Silbiger VN. Relationship between circulating VCAM-1, ICAM-1, E-selectin and MMP9 and the extent of coronary lesions. Clinics (Sao Paulo). 2018; 73:e203. PMID: 29846413.
    Citations: 7     Fields:    Translation:Humans
  23. Silva HPVD, Arruda TTS, Souza KSC, Bezerra JF, Leite GCP, Brito MEF, Lima VMGDM, Luchessi AD, Bortolin RH, Ururahy MAG, Rezende AA. Risk factors and comorbidities in Brazilian patients with orofacial clefts. Braz Oral Res. 2018; 32:e24. PMID: 29641641.
    Citations: 5     Fields:    Translation:HumansPHPublic Health
  24. da Silva HPV, Oliveira GHM, Ururahy MAG, Bezerra JF, de Souza KSC, Bortolin RH, Luchessi AD, Silbiger VN, Lima VMGDM, Leite GCP, Brito MEF, Ribeiro EM, Gil-da-Silva-Lopes VL, de Rezende AA. Application of high-resolution array platform for genome-wide copy number variation analysis in patients with nonsyndromic cleft lip and palate. J Clin Lab Anal. 2018 Jul; 32(6):e22428. PMID: 29512191.
    Citations: 3     Fields:    
  25. de Freitas RCC, Bortolin RH, Lopes MB, Tamborlin L, Meneguello L, Silbiger VN, Hirata RDC, Hirata MH, Luchessi AD, Luchessi AD. Modulation of miR-26a-5p and miR-15b-5p Exosomal Expression Associated with Clopidogrel-Induced Hepatotoxicity in HepG2 Cells. Front Pharmacol. 2017; 8:906. PMID: 29311920.
    Citations: 9     
  26. Marques D, Ferreira-Costa LR, Ferreira-Costa LL, Correa RDS, Borges AMP, Ito FR, Ramos CCO, Bortolin RH, Luchessi AD, Ribeiro-Dos-Santos Â, Santos S, Silbiger VN. Association of insertion-deletions polymorphisms with colorectal cancer risk and clinical features. World J Gastroenterol. 2017 Oct 07; 23(37):6854-6867. PMID: 29085228.
    Citations: 6     Fields:    Translation:Humans
  27. Silva FS, Bortolin RH, Araújo DN, Marques DES, Lima JPMS, Rezende AA, Vieira WHB, Silva NB, Medeiros KCP, Ackermann PW, Abreu BJ, Dias FAL. Exercise training ameliorates matrix metalloproteinases 2 and 9 messenger RNA expression and mitigates adverse left ventricular remodeling in streptozotocin-induced diabetic rats. Cardiovasc Pathol. 2017 Jul - Aug; 29:37-44. PMID: 28550760.
    Citations: 4     Fields:    Translation:Animals
  28. Ferreira ECS, Bortolin RH, Freire-Neto FP, Souza KSC, Bezerra JF, Ururahy MAG, Ramos AMO, Himelfarb ST, Abreu BJ, Didone TVN, Pedrosa LFC, Medeiros AC, Doi SQ, Brandão-Neto J, Hirata RDC, Rezende LA, Almeida MG, Hirata MH, Rezende AA. Zinc supplementation reduces RANKL/OPG ratio and prevents bone architecture alterations in ovariectomized and type 1 diabetic rats. Nutr Res. 2017 Apr; 40:48-56. PMID: 28473060.
    Citations: 7     Fields:    Translation:Animals
  29. Lopes MB, Freitas RC, Hirata MH, Hirata R, Rezende AA, Silbiger VN, Bortolin RH, Luchessi AD. mRNA-miRNA integrative analysis of diabetes-induced cardiomyopathy in rats. Front Biosci (Schol Ed). 2017 03 01; 9(2):194-229. PMID: 28199183.
    Citations: 6     Fields:    Translation:AnimalsCells
  30. Luchessi AD, Concheiro M, Germano JF, Silbiger VN, Bortolin RH, Cruz A, Quintela O, Brion M, Carracedo A, Iñiguez A, Bravo M, López-Rivadulla M, Hirata RD, Sousa AG, Hirata MH. ABCC3 Polymorphisms and mRNA Expression Influence the Concentration of a Carboxylic Acid Metabolite in Patients on Clopidogrel and Aspirin Therapy. Basic Clin Pharmacol Toxicol. 2017 May; 120(5):466-474. PMID: 27862978.
    Citations: 1     Fields:    Translation:HumansCells
  31. Bortolin RH, Freire Neto FP, Arcaro CA, Bezerra JF, da Silva FS, Ururahy MA, Souza KS, Lima VM, Luchessi AD, Lima FP, Lia Fook MV, da Silva BJ, Almeida MD, Abreu BJ, de Rezende LA, de Rezende AA. Anabolic Effect of Insulin Therapy on the Bone: Osteoprotegerin and Osteocalcin Up-Regulation in Streptozotocin-Induced Diabetic Rats. Basic Clin Pharmacol Toxicol. 2017 Mar; 120(3):227-234. PMID: 27651300.
    Citations: 4     Fields:    Translation:AnimalsCells
  32. Duarte MK, de Araújo JN, Duarte VH, de Oliveira KM, de Oliveira JM, Carioca AA, Bortolin RH, Rezende AA, Hirata MH, Hirata RD, Waitzberg DL, Lima SC, Luchessi AD, Silbiger VN. The relationship of the oleic acid level and ECHDC3 mRNA expression with the extent of coronary lesion. Lipids Health Dis. 2016 Sep 01; 15:144. PMID: 27586541.
    Citations: 5     Fields:    Translation:Humans
  33. Freitas RCC, Bortolin RH, Lopes MB, Hirata MH, Hirata RDC, Silbiger VN, Luchessi AD. Integrated analysis of miRNA and mRNA gene expression microarrays: Influence on platelet reactivity, clopidogrel response and drug-induced toxicity. Gene. 2016 Nov 15; 593(1):172-178. PMID: 27543010.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  34. de Souza KS, Ururahy MA, da Costa Oliveira YM, Loureiro MB, da Silva HP, Bortolin RH, Melo Dos Santos F, Luchessi AD, Neto JJ, Arrais RF, Hirata RD, das Graças Almeida M, Hirata MH, de Rezende AA. Low bone mineral density in patients with type 1 diabetes: association with reduced expression of IGF1, IGF1R and TGF?B?1 in peripheral blood mononuclear cells. Diabetes Metab Res Rev. 2016 09; 32(6):589-95. PMID: 26663878.
    Citations: 8     Fields:    Translation:HumansCells
  35. Bortolin RH, da Graça Azevedo Abreu BJ, Abbott Galvão Ururahy M, Costa de Souza KS, Bezerra JF, Loureiro MB, da Silva FS, Marques DE, Batista AA, Oliveira G, Luchessi AD, Lima VM, Miranda CE, Lia Fook MV, Almeida Md, de Rezende LA, de Rezende AA. Protection against T1DM-Induced Bone Loss by Zinc Supplementation: Biomechanical, Histomorphometric, and Molecular Analyses in STZ-Induced Diabetic Rats. PLoS One. 2015; 10(5):e0125349. PMID: 25933189.
    Citations: 14     Fields:    Translation:HumansAnimals
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.