Harvard Catalyst Profiles

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Anton Lennikov, Ph.D., M.D.


Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Shu DY, Chaudhary S, Cho KS, Lennikov A, Miller WP, Thorn DC, Yang M, McKay TB. Role of Oxidative Stress in Ocular Diseases: A Balancing Act. Metabolites. 2023 Jan 27; 13(2). PMID: 36837806; PMCID: PMC9960073.
  2. Lennikov A, Mukwaya A, Saddala MS, Huang H. Deficiency of C-X-C chemokine receptor type 5 (CXCR5) gene causes dysfunction of retinal pigment epithelium cells. Lab Invest. 2021 Feb; 101(2):228-244. PMID: 36775488.
    Citations:    Fields:    
  3. Yang M, Lennikov A, Chang K, Ashok A, Lee C, Cho KS, Utheim TP, Dartt DA, Chen DF. Transcorneal but not transpalpebral electrical stimulation disrupts mucin homeostasis of the ocular surface. BMC Ophthalmol. 2022 Dec 15; 22(1):490. PMID: 36522696; PMCID: PMC9756492.
    Citations:    Fields:    Translation:AnimalsCells
  4. Huang H, Saddala MS, Mukwaya A, Mohan RR, Lennikov A. Association of Placental Growth Factor and Angiopoietin in Human Retinal Endothelial Cell-Pericyte co-Cultures and iPSC-Derived Vascular Organoids. Curr Eye Res. 2023 03; 48(3):297-311. PMID: 36458540.
    Citations:    Fields:    
  5. Lennikov A, Yang M, Chang K, Pan L, Saddala MS, Lee C, Ashok A, Cho KS, Utheim TP, Chen DF. Direct modulation of microglial function by electrical field. Front Cell Dev Biol. 2022; 10:980775. PMID: 36158207; PMCID: PMC9493490.
    Citations: 1     
  6. Rafat M, Jabbarvand M, Sharma N, Xeroudaki M, Tabe S, Omrani R, Thangavelu M, Mukwaya A, Fagerholm P, Lennikov A, Askarizadeh F, Lagali N. Bioengineered corneal tissue for minimally invasive vision restoration in advanced keratoconus in two clinical cohorts. Nat Biotechnol. 2023 01; 41(1):70-81. PMID: 35953672; PMCID: PMC9849136.
    Citations: 3     Fields:    Translation:Animals
  7. Pang K, Lennikov A, Yang M. Hypoxia adaptation in the cornea: Current animal models and underlying mechanisms. Animal Model Exp Med. 2021 12; 4(4):300-310. PMID: 34977481; PMCID: PMC8690994.
    Citations: 5     Fields:    Translation:Animals
  8. Saddala MS, Lennikov A, Mukwaya A, Yang X, Tang S, Huang H. Data mining and network analysis reveals C-X-C chemokine receptor type 5 is involved in the pathophysiology of age-related macular degeneration. J Biomol Struct Dyn. 2022; 40(21):10783-10792. PMID: 34243690.
    Citations: 1     Fields:    Translation:HumansAnimals
  9. Lachota M, Lennikov A, Malmberg KJ, Zagozdzon R. Bioinformatic Analysis Reveals Central Role for Tumor-Infiltrating Immune Cells in Uveal Melanoma Progression. J Immunol Res. 2021; 2021:9920234. PMID: 34195299.
    Citations: 3     Fields:    Translation:HumansCells
  10. Hikage F, Lennikov A, Mukwaya A, Lachota M, Ida Y, Utheim TP, Chen DF, Huang H, Ohguro H. NF-?B activation in retinal microglia is involved in the inflammatory and neovascularization signaling in laser-induced choroidal neovascularization in mice. Exp Cell Res. 2021 06 01; 403(1):112581. PMID: 33811906; PMCID: PMC8479856.
    Citations: 9     Fields:    Translation:AnimalsCells
  11. Balt J, Uehara O, Abiko Y, Jamyanjav B, Jav S, Nagasawa T, Mori M, Horie Y, Fujita M, Lennikov A, Ohta T, Hiraoka M, Iwata D, Namba K, Ohno S, Kitaichi N. Alteration of oral flora in Mongolian patients with Behçet's disease: a multicentre study. Clin Exp Rheumatol. 2020 Sep-Oct; 38 Suppl 127(5):80-85. PMID: 33331270.
    Citations: 1     Fields:    Translation:HumansCells
  12. Lennikov A, Mukwaya A, Fan L, Saddala MS, De Falco S, Huang H. Synergistic interactions of PlGF and VEGF contribute to blood-retinal barrier breakdown through canonical NF?B activation. Exp Cell Res. 2020 12 15; 397(2):112347. PMID: 33130176.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  13. Xeroudaki M, Thangavelu M, Lennikov A, Ratnayake A, Bisevac J, Petrovski G, Fagerholm P, Rafat M, Lagali N. A porous collagen-based hydrogel and implantation method for corneal stromal regeneration and sustained local drug delivery. Sci Rep. 2020 10 09; 10(1):16936. PMID: 33037282.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  14. Lennikov A, Mukwaya A, Saddala MS, Huang H. Deficiency of C-X-C chemokine receptor type 5 (CXCR5) gene causes dysfunction of retinal pigment epithelium cells. Lab Invest. 2021 02; 101(2):228-244. PMID: 32994482.
    Citations: 3     Fields:    Translation:AnimalsCells
  15. Huang H, Saddala MS, Lennikov A, Mukwaya A, Fan L. RNA-Seq reveals placental growth factor regulates the human retinal endothelial cell barrier integrity by transforming growth factor (TGF-ß) signaling. Mol Cell Biochem. 2020 Dec; 475(1-2):93-106. PMID: 32813141.
    Citations: 4     Fields:    Translation:HumansCells
  16. Saddala MS, Lennikov A, Huang H. RNA-seq data from C-X-C chemokine receptor type 5 (CXCR5) gene knockout aged mice with retinal degeneration phenotype. Data Brief. 2020 Aug; 31:105915. PMID: 32642521.
    Citations: 1     
  17. Saddala MS, Lennikov A, Mukwaya A, Huang H. Transcriptome-Wide Analysis of CXCR5 Deficient Retinal Pigment Epithelial (RPE) Cells Reveals Molecular Signatures of RPE Homeostasis. Biomedicines. 2020 Jun 01; 8(6). PMID: 32492870; PMCID: PMC7345337.
    Citations: 6     
  18. Huang H, Lennikov A. CXCR5/NRF2 double knockout mice develop retinal degeneration phenotype at early adult age. Exp Eye Res. 2020 07; 196:108061. PMID: 32387618.
    Citations: 2     Fields:    Translation:AnimalsCells
  19. Saddala MS, Lennikov A, Mukwaya A, Yang Y, Hill MA, Lagali N, Huang H. Discovery of novel L-type voltage-gated calcium channel blockers and application for the prevention of inflammation and angiogenesis. J Neuroinflammation. 2020 Apr 25; 17(1):132. PMID: 32334630.
    Citations: 10     Fields:    Translation:AnimalsCells
  20. Balt J, Jamyanjav B, Jav S, Dandii Z, Ganbold C, Horie Y, Lennikov A, Uehara O, Ohno S, Kitaichi N. Clinical features of Behcet's disease in Mongolia: a multicenter study. Clin Rheumatol. 2020 Sep; 39(9):2697-2706. PMID: 32157471.
    Citations:    Fields:    Translation:Humans
  21. Saddala MS, Lennikov A, Huang H. Discovery of Small-Molecule Activators for Glucose-6-Phosphate Dehydrogenase (G6PD) Using Machine Learning Approaches. Int J Mol Sci. 2020 Feb 23; 21(4). PMID: 32102234.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  22. Saddala MS, Lennikov A, Huang H. Placental growth factor regulates the pentose phosphate pathway and antioxidant defense systems in human retinal endothelial cells. J Proteomics. 2020 04 15; 217:103682. PMID: 32058040; PMCID: PMC7439780.
    Citations: 7     Fields:    Translation:HumansCells
  23. Saddala MS, Lennikov A, Bouras A, Huang H. RNA-Seq reveals differential expression profiles and functional annotation of genes involved in retinal degeneration in Pde6c mutant Danio rerio. BMC Genomics. 2020 Feb 07; 21(1):132. PMID: 32033529.
    Citations: 5     Fields:    Translation:AnimalsCells
  24. Huang H, Lennikov A, Saddala MS, Gozal D, Grab DJ, Khalyfa A, Fan L. Placental growth factor negatively regulates retinal endothelial cell barrier function through suppression of glucose-6-phosphate dehydrogenase and antioxidant defense systems. FASEB J. 2019 12; 33(12):13695-13709. PMID: 31585507; PMCID: PMC6894064.
    Citations: 10     Fields:    Translation:HumansCells
  25. Mukwaya A, Mirabelli P, Lennikov A, Thangavelu M, Ntzouni M, Jensen L, Peebo B, Lagali N. Revascularization after angiogenesis inhibition favors new sprouting over abandoned vessel reuse. Angiogenesis. 2019 11; 22(4):553-567. PMID: 31486010.
    Citations: 9     Fields:    Translation:AnimalsCells
  26. Lennikov A, Saddala MS, Mukwaya A, Tang S, Huang H. Autoimmune-Mediated Retinopathy in CXCR5-Deficient Mice as the Result of Age-Related Macular Degeneration Associated Proteins Accumulation. Front Immunol. 2019; 10:1903. PMID: 31474986.
    Citations: 8     Fields:    Translation:AnimalsCells
  27. Mukwaya A, Mirabelli P, Lennikov A, Thangavelu M, Jensen L, Peebo B, Lagali N. Repeat Corneal Neovascularization is Characterized by More Aggressive Inflammation and Vessel Invasion Than in the Initial Phase. Invest Ophthalmol Vis Sci. 2019 07 01; 60(8):2990-3001. PMID: 31310656.
    Citations: 5     Fields:    Translation:AnimalsCells
  28. Ali Z, Mukwaya A, Biesemeier A, Ntzouni M, Ramsköld D, Giatrellis S, Mammadzada P, Cao R, Lennikov A, Marass M, Gerri C, Hildesjö C, Taylor M, Deng Q, Peebo B, Del Peso L, Kvanta A, Sandberg R, Schraermeyer U, Andre H, Steffensen JF, Lagali N, Cao Y, Kele J, Jensen LD. Intussusceptive Vascular Remodeling Precedes Pathological Neovascularization. Arterioscler Thromb Vasc Biol. 2019 07; 39(7):1402-1418. PMID: 31242036; PMCID: PMC6636809.
    Citations: 12     Fields:    Translation:HumansAnimals
  29. Saddala MS, Lennikov A, Mukwaya A, Fan L, Hu Z, Huang H. Transcriptome-wide analysis of differentially expressed chemokine receptors, SNPs, and SSRs in the age-related macular degeneration. Hum Genomics. 2019 03 20; 13(1):15. PMID: 30894217.
    Citations: 12     Fields:    Translation:HumansCells
  30. Saddala MS, Lennikov A, Grab DJ, Liu GS, Tang S, Huang H. Proteomics reveals ablation of PlGF increases antioxidant and neuroprotective proteins in the diabetic mouse retina. Sci Rep. 2018 11 13; 8(1):16728. PMID: 30425286.
    Citations: 14     Fields:    Translation:Animals
  31. Mukwaya A, Lennikov A, Xeroudaki M, Mirabelli P, Lachota M, Jensen L, Peebo B, Lagali N. Time-dependent LXR/RXR pathway modulation characterizes capillary remodeling in inflammatory corneal neovascularization. Angiogenesis. 2018 05; 21(2):395-413. PMID: 29445990.
    Citations: 16     Fields:    Translation:AnimalsCells
  32. Lennikov A, Mirabelli P, Mukwaya A, Schaupper M, Thangavelu M, Lachota M, Ali Z, Jensen L, Lagali N. Selective IKK2 inhibitor IMD0354 disrupts NF-?B signaling to suppress corneal inflammation and angiogenesis. Angiogenesis. 2018 05; 21(2):267-285. PMID: 29332242.
    Citations: 24     Fields:    Translation:HumansAnimalsCells
  33. Harada F, Morikawa T, Lennikov A, Mukwaya A, Schaupper M, Uehara O, Takai R, Yoshida K, Sato J, Horie Y, Sakaguchi H, Wu CZ, Abiko Y, Lagali N, Kitaichi N. Protective Effects of Oral Astaxanthin Nanopowder against Ultraviolet-Induced Photokeratitis in Mice. Oxid Med Cell Longev. 2017; 2017:1956104. PMID: 29104724; PMCID: PMC5637851.
    Citations: 7     Fields:    Translation:Animals
  34. Mirabelli P, Mukwaya A, Lennikov A, Xeroudaki M, Peebo B, Schaupper M, Lagali N. Genome-wide expression differences in anti-Vegf and dexamethasone treatment of inflammatory angiogenesis in the rat cornea. Sci Rep. 2017 08 15; 7(1):7616. PMID: 28811496.
    Citations: 6     Fields:    Translation:AnimalsCells
  35. Mukwaya A, Mirabelli P, Lennikov A, Xeroudaki M, Schaupper M, Peebo B, Lagali N. Genome-wide expression datasets of anti-VEGF and dexamethasone treatment of angiogenesis in the rat cornea. Sci Data. 2017 08 15; 4:170111. PMID: 28809847; PMCID: PMC5556618.
    Citations: 2     Fields:    Translation:Animals
  36. Mukwaya A, Lindvall JM, Xeroudaki M, Peebo B, Ali Z, Lennikov A, Jensen LD, Lagali N. A microarray whole-genome gene expression dataset in a rat model of inflammatory corneal angiogenesis. Sci Data. 2016 11 22; 3:160103. PMID: 27874850.
    Citations: 6     Fields:    Translation:Animals
  37. Mukwaya A, Peebo B, Xeroudaki M, Ali Z, Lennikov A, Jensen L, Lagali N. Factors regulating capillary remodeling in a reversible model of inflammatory corneal angiogenesis. Sci Rep. 2016 08 26; 6:32137. PMID: 27561355.
    Citations: 15     Fields:    Translation:Animals
  38. Lennikov A, Hiraoka M, Abe A, Ohno S, Fujikawa T, Itai A, Ohguro H. I?B kinase-ß inhibitor IMD-0354 beneficially suppresses retinal vascular permeability in streptozotocin-induced diabetic mice. Invest Ophthalmol Vis Sci. 2014 Sep 09; 55(10):6365-73. PMID: 25205865.
    Citations: 11     Fields:    Translation:Animals
  39. Dong Z, Iwata D, Kitaichi N, Takeuchi M, Sato M, Endo N, Iwabuchi K, Ando R, Fukuhara J, Kinoshita S, Lennikov A, Kitamura M, Mizuuchi K, Kanda A, Noda K, Namba K, Yamagishi S, Ohno S, Ishida S. Amelioration of experimental autoimmune uveoretinitis by inhibition of glyceraldehyde-derived advanced glycation end-product formation. J Leukoc Biol. 2014 Dec; 96(6):1077-85. PMID: 25201803.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  40. Lennikov A, Kitaichi N, Noda K, Mizuuchi K, Ando R, Dong Z, Fukuhara J, Kinoshita S, Namba K, Ohno S, Ishida S. Amelioration of endotoxin-induced uveitis treated with the sea urchin pigment echinochrome in rats. Mol Vis. 2014; 20:171-7. PMID: 24520186.
    Citations: 25     Fields:    Translation:AnimalsCells
  41. Lennikov A, Alekberova Z, Goloeva R, Kitaichi N, Denisov L, Namba K, Takeno M, Ishigatsubo Y, Mizuki N, Nasonov E, Ishida S, Ohno S. Single center study on ethnic and clinical features of Behcet's disease in Moscow, Russia. Clin Rheumatol. 2015 Feb; 34(2):321-7. PMID: 24322831.
    Citations: 7     Fields:    Translation:Humans
  42. Hiraoka M, Abe A, Lennikov A, Kitaichi N, Ishida S, Ohguro H. Increase of lysosomal phospholipase A2 in aqueous humor by uveitis. Exp Eye Res. 2014 Jan; 118:13-9. PMID: 24161624.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  43. Lennikov A, Kitaichi N, Kase S, Noda K, Horie Y, Nakai A, Ohno S, Ishida S. Induction of heat shock protein 70 ameliorates ultraviolet-induced photokeratitis in mice. Int J Mol Sci. 2013 Jan 22; 14(1):2175-89. PMID: 23340653.
    Citations: 9     Fields:    Translation:Animals
  44. Fukuhara J, Noda K, Murata M, Namba S, Kinoshita S, Dong Z, Ando R, Lennikov A, Kanda A, Ishida S. Tissue kallikrein attenuates choroidal neovascularization via cleavage of vascular endothelial growth factor. Invest Ophthalmol Vis Sci. 2013 Jan 09; 54(1):274-9. PMID: 23233257.
    Citations: 6     Fields:    Translation:Animals
  45. Lennikov A, Kitaichi N, Noda K, Ando R, Dong Z, Fukuhara J, Kinoshita S, Namba K, Mizutani M, Fujikawa T, Itai A, Ohno S, Ishida S. Amelioration of endotoxin-induced uveitis treated with an I?B kinase ß inhibitor in rats. Mol Vis. 2012; 18:2586-97. PMID: 23112571.
    Citations: 13     Fields:    Translation:AnimalsCells
  46. Lennikov A, Kitaichi N, Fukase R, Murata M, Noda K, Ando R, Ohguchi T, Kawakita T, Ohno S, Ishida S. Amelioration of ultraviolet-induced photokeratitis in mice treated with astaxanthin eye drops. Mol Vis. 2012; 18:455-64. PMID: 22393271.
    Citations: 17     Fields:    Translation:AnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.