Harvard Catalyst Profiles

Contact, publication, and social network information about Harvard faculty and fellows.

Jennifer Rosslyn Riggs, M.D.

Title
Institution
Department
Address

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Elsner J, Cashion D, Robinson D, Bahmanyar S, Tehrani L, Fultz KE, Narla RK, Peng X, Tran T, Apuy J, LeBrun L, Leftheris K, Boylan JF, Zhu D, Riggs JR. Structure-Guided Optimization Provides a Series of TTK Protein Inhibitors with Potent Antitumor Activity. J Med Chem. 2021 09 09; 64(17):12670-12679. PMID: 34459599.
    Citations:    Fields:    Translation:HumansCells
  2. Chamberlain PP, D'Agostino LA, Ellis JM, Hansen JD, Matyskiela ME, McDonald JJ, Riggs JR, Hamann LG. Evolution of Cereblon-Mediated Protein Degradation as a Therapeutic Modality. ACS Med Chem Lett. 2019 Dec 12; 10(12):1592-1602. PMID: 31857833.
    Citations: 12     
  3. Riggs JR, Elsner J, Cashion D, Robinson D, Tehrani L, Nagy M, Fultz KE, Krishna Narla R, Peng X, Tran T, Kulkarni A, Bahmanyar S, Condroski K, Pagarigan B, Fenalti G, LeBrun L, Leftheris K, Zhu D, Boylan JF. Design and Optimization Leading to an Orally Active TTK Protein Kinase Inhibitor with Robust Single Agent Efficacy. J Med Chem. 2019 05 09; 62(9):4401-4410. PMID: 30998356.
    Citations: 1     Fields:    Translation:AnimalsCells
  4. Zhu D, Xu S, Deyanat-Yazdi G, Peng SX, Barnes LA, Narla RK, Tran T, Mikolon D, Ning Y, Shi T, Jiang N, Raymon HK, Riggs JR, Boylan JF. Synthetic Lethal Strategy Identifies a Potent and Selective TTK and CLK1/2 Inhibitor for Treatment of Triple-Negative Breast Cancer with a Compromised G1-S Checkpoint. Mol Cancer Ther. 2018 08; 17(8):1727-1738. PMID: 29866747.
    Citations: 14     Fields:    Translation:HumansAnimalsCells
  5. Riggs JR, Nagy M, Elsner J, Erdman P, Cashion D, Robinson D, Harris R, Huang D, Tehrani L, Deyanat-Yazdi G, Narla RK, Peng X, Tran T, Barnes L, Miller T, Katz J, Tang Y, Chen M, Moghaddam MF, Bahmanyar S, Pagarigan B, Delker S, LeBrun L, Chamberlain PP, Calabrese A, Canan SS, Leftheris K, Zhu D, Boylan JF. The Discovery of a Dual TTK Protein Kinase/CDC2-Like Kinase (CLK2) Inhibitor for the Treatment of Triple Negative Breast Cancer Initiated from a Phenotypic Screen. J Med Chem. 2017 11 09; 60(21):8989-9002. PMID: 28991472.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  6. Mortensen DS, Perrin-Ninkovic SM, Shevlin G, Elsner J, Zhao J, Whitefield B, Tehrani L, Sapienza J, Riggs JR, Parnes JS, Papa P, Packard G, Lee BG, Harris R, Correa M, Bahmanyar S, Richardson SJ, Peng SX, Leisten J, Khambatta G, Hickman M, Gamez JC, Bisonette RR, Apuy J, Cathers BE, Canan SS, Moghaddam MF, Raymon HK, Worland P, Narla RK, Fultz KE, Sankar S. Optimization of a Series of Triazole Containing Mammalian Target of Rapamycin (mTOR) Kinase Inhibitors and the Discovery of CC-115. J Med Chem. 2015 Jul 23; 58(14):5599-608. PMID: 26102506.
    Citations: 26     Fields:    Translation:HumansAnimalsCells
  7. Mortensen DS, Perrin-Ninkovic SM, Shevlin G, Zhao J, Packard G, Bahmanyar S, Correa M, Elsner J, Harris R, Lee BG, Papa P, Parnes JS, Riggs JR, Sapienza J, Tehrani L, Whitefield B, Apuy J, Bisonette RR, Gamez JC, Hickman M, Khambatta G, Leisten J, Peng SX, Richardson SJ, Cathers BE, Canan SS, Moghaddam MF, Raymon HK, Worland P, Narla RK, Fultz KE, Sankar S. Discovery of mammalian target of rapamycin (mTOR) kinase inhibitor CC-223. J Med Chem. 2015 Jul 09; 58(13):5323-33. PMID: 26083478.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  8. Packard GK, Papa P, Riggs JR, Erdman P, Tehrani L, Robinson D, Harris R, Shevlin G, Perrin-Ninkovic S, Hilgraf R, McCarrick MA, Tran T, Fleming Y, Bai A, Richardson S, Katz J, Tang Y, Leisten J, Moghaddam M, Cathers B, Zhu D, Sakata S. Discovery and optimization of thieno[2,3-d]pyrimidines as B-Raf inhibitors. Bioorg Med Chem Lett. 2012 Jan 01; 22(1):747-52. PMID: 22137342.
    Citations: 1     Fields:    Translation:HumansCells
  9. Valiulin RA, Dressen DG, Riggs JR, Habte FM, Kutateladze AG. Effect of intramolecular Paternò-Büchi reaction on the thermodynamics and kinetics of nearly degenerate [3,3]-sigmatropic shift in fluxional polycycles. J Org Chem. 2009 May 01; 74(9):3484-90. PMID: 19344135.
    Citations:    Fields:    
  10. Hu H, Kolesnikov A, Riggs JR, Wesson KE, Stephens R, Leahy EM, Shrader WD, Sprengeler PA, Green MJ, Sanford E, Nguyen M, Gjerstad E, Cabuslay R, Young WB. Potent 4-amino-5-azaindole factor VIIa inhibitors. Bioorg Med Chem Lett. 2006 Sep 01; 16(17):4567-70. PMID: 16793264.
    Citations: 2     Fields:    Translation:Cells
  11. Vijaykumar D, Rai R, Shaghafi M, Ton T, Torkelson S, Leahy EM, Riggs JR, Hu H, Sprengeler PA, Shrader WD, O'Bryan C, Cabuslay R, Sanford E, Gjerstadt E, Liu L, Sukbuntherng J, Young WB. Efforts toward oral bioavailability in factor VIIa inhibitors. Bioorg Med Chem Lett. 2006 Jul 15; 16(14):3829-32. PMID: 16650987.
    Citations: 1     Fields:    Translation:Animals
  12. Riggs JR, Hu H, Kolesnikov A, Leahy EM, Wesson KE, Shrader WD, Vijaykumar D, Wahl TA, Tong Z, Sprengeler PA, Green MJ, Yu C, Katz BA, Sanford E, Nguyen M, Cabuslay R, Young WB. Novel 5-azaindole factor VIIa inhibitors. Bioorg Med Chem Lett. 2006 Jun 15; 16(12):3197-200. PMID: 16621549.
    Citations: 2     Fields:    Translation:Cells
  13. Riggs JR, Kolesnikov A, Hendrix J, Young WB, Shrader WD, Vijaykumar D, Stephens R, Liu L, Pan L, Mordenti J, Green MJ, Sukbuntherng J. Factor VIIa inhibitors: a prodrug strategy to improve oral bioavailability. Bioorg Med Chem Lett. 2006 Apr 15; 16(8):2224-8. PMID: 16458507.
    Citations: 4     Fields:    Translation:Animals
Local representatives can answer questions about the Profiles website or help with editing a profile or issues with profile data. For assistance with this profile: HMS/HSDM faculty should contact contactcatalyst.harvard.edu. For faculty or fellow appointment updates and changes, please ask your appointing department to contact HMS. For fellow personal and demographic information, contact HMS Human Resources at human_resourceshms.harvard.edu. For faculty personal and demographic information, contact HMS Office for Faculty Affairs at facappthms.harvard.edu.
Riggs's Networks
Click the
Explore
buttons for more information and interactive visualizations!
Concepts (58)
Explore
_
Similar People (60)
Explore
_
Same Department 
Explore
_
Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.