Harvard Catalyst Profiles

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Alexander N. Gorelick, Ph.D.

Title
Institution
Department
Address
Profile Picture

Biography
education and training
Cornell University/Memorial Sloan Kettering Cancer Center, New York City, NYPh.D.2020Tri-Institutional PhD Program in Computational Biology and Medicine
awards and honors
2022 - 2025
Life Sciences Research Foundation postdoctoral fellowship (Sponsor: MacMillan Family Foundation)

Bibliographic
selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Wassenaar EC, Gorelick AN, Hung WT, Cheek DM, Kucukkose E, Lee IH, Blohmer M, Degner S, Giunta P, Wiezer RM, Raicu MG, Ubink I, Klaasen SJ, Lansu N, Watson EV, Corcoran RB, Boland G, Getz G, Kops GJ, Juric D, Lennerz JK, Boerma D, Kranenburg O, Naxerova K. A unique interplay of access and selection shapes peritoneal metastasis evolution in colorectal cancer. bioRxiv. 2024 Sep 27. PMID: 39386634; PMCID: PMC11463674.
    Citations:
  2. Portelinha A, Wang S, Parsa S, Jiang M, Gorelick AN, Mohanty S, Sharma S, de Stanchina E, Berishaj M, Zhao C, Heward J, Aryal NK, Tavana O, Wen J, Fitzgibbon J, Dogan A, Younes A, Melnick AM, Wendel HG. SETD1B mutations confer apoptosis resistance and BCL2 independence in B cell lymphoma. J Exp Med. 2024 Oct 07; 221(10). PMID: 39235528; PMCID: PMC11380151.
    Citations:
    Fields: AllAllergy and ImmunologyMedMedicine (General)Translation:HumansAnimalsCells
  3. Kim M, Gorelick AN, Vàzquez-García I, Williams MJ, Salehi S, Shi H, Weiner AC, Ceglia N, Funnell T, Park T, Boscenco S, O'Flanagan CH, Jiang H, Grewal D, Tang C, Rusk N, Gammage PA, McPherson A, Aparicio S, Shah SP, Reznik E. Single-cell mtDNA dynamics in tumors is driven by coregulation of nuclear and mitochondrial genomes. Nat Genet. 2024 May; 56(5):889-899. PMID: 38741018; PMCID: PMC11096122.
    Citations: 1
    Fields: GenGenetics, MedicalTranslation:HumansAnimalsCells
  4. Küçükköse E, Laoukili J, Gorelick AN, Degner S, Laclé MM, van den Bent L, Peters NA, Verheem A, Hung WT, Frenkel NC, Wassenaar ECE, Lansu N, Lenos KJ, Vermeulen L, Koopman M, Roodhart JML, Kops GJPL, Borel Rinkes IHM, Hagendoorn J, Naxerova K, Kranenburg O. Lymphatic Invasion of Plakoglobin-Dependent Tumor Cell Clusters Drives Formation of Polyclonal Lung Metastases in Colon Cancer. Gastroenterology. 2023 08; 165(2):429-444.e15. PMID: 36906044.
    Citations: 4
    Fields: GasGastroenterologyTranslation:HumansAnimals
  5. Ganly I, Liu EM, Kuo F, Makarov V, Dong Y, Park J, Gong Y, Gorelick AN, Knauf JA, Benedetti E, Tait-Mulder J, Morris LGT, Fagin JA, Intlekofer AM, Krumsiek J, Gammage PA, Ghossein R, Xu B, Chan TA, Reznik E. Mitonuclear genotype remodels the metabolic and microenvironmental landscape of Hürthle cell carcinoma. Sci Adv. 2022 06 24; 8(25):eabn9699. PMID: 35731870; PMCID: PMC9216518.
    Citations: 8
    Fields: SciScienceTranslation:HumansCells
  6. Shrestha Bhattarai T, Shamu T, Gorelick AN, Chang MT, Chakravarty D, Gavrila EI, Donoghue MTA, Gao J, Patel S, Gao SP, Reynolds MH, Phillips SM, Soumerai T, Abida W, Hyman DM, Schram AM, Solit DB, Smyth LM, Taylor BS. AKT mutant allele-specific activation dictates pharmacologic sensitivities. Nat Commun. 2022 04 19; 13(1):2111. PMID: 35440569; PMCID: PMC9018718.
    Citations: 9
    Fields: BioBiologySciScienceTranslation:HumansCTClinical Trials
  7. Gorelick AN, Naxerova K. Mutational clocks tick differently across species. Nature. 2022 04; 604(7906):435-436. PMID: 35418556.
    Citations: 2
    Fields: SciScienceTranslation:Animals
  8. Gorelick AN, Kim M, Chatila WK, La K, Hakimi AA, Berger MF, Taylor BS, Gammage PA, Reznik E. Respiratory complex and tissue lineage drive recurrent mutations in tumour mtDNA. Nat Metab. 2021 04; 3(4):558-570. PMID: 33833465; PMCID: PMC9304985.
    Citations: 44
    Fields: MetMetabolismTranslation:HumansCells
  9. Cocco E, Lee JE, Kannan S, Schram AM, Won HH, Shifman S, Kulick A, Baldino L, Toska E, Arruabarrena-Aristorena A, Kittane S, Wu F, Cai Y, Arena S, Mussolin B, Kannan R, Vasan N, Gorelick AN, Berger MF, Novoplansky O, Jagadeeshan S, Liao Y, Rix U, Misale S, Taylor BS, Bardelli A, Hechtman JF, Hyman DM, Elkabets M, de Stanchina E, Verma CS, Ventura A, Drilon A, Scaltriti M. TRK xDFG Mutations Trigger a Sensitivity Switch from Type I to II Kinase Inhibitors. Cancer Discov. 2021 01; 11(1):126-141. PMID: 33004339; PMCID: PMC8012405.
    Citations: 18
    Fields: NeoNeoplasmsTranslation:Humans
  10. Hanrahan AJ, Sylvester BE, Chang MT, Elzein A, Gao J, Han W, Liu Y, Xu D, Gao SP, Gorelick AN, Jones AM, Kiliti AJ, Nissan MH, Nimura CA, Poteshman AN, Yao Z, Gao Y, Hu W, Wise HC, Gavrila EI, Shoushtari AN, Tiwari S, Viale A, Abdel-Wahab O, Merghoub T, Berger MF, Rosen N, Taylor BS, Solit DB. Leveraging Systematic Functional Analysis to Benchmark an In Silico Framework Distinguishes Driver from Passenger MEK Mutants in Cancer. Cancer Res. 2020 10 01; 80(19):4233-4243. PMID: 32641410; PMCID: PMC7541597.
    Citations: 13
    Fields: NeoNeoplasmsTranslation:Humans
  11. Gorelick AN, Sánchez-Rivera FJ, Cai Y, Bielski CM, Biederstedt E, Jonsson P, Richards AL, Vasan N, Penson AV, Friedman ND, Ho YJ, Baslan T, Bandlamudi C, Scaltriti M, Schultz N, Lowe SW, Reznik E, Taylor BS. Phase and context shape the function of composite oncogenic mutations. Nature. 2020 06; 582(7810):100-103. PMID: 32461694; PMCID: PMC7294994.
    Citations: 22
    Fields: SciScienceTranslation:HumansAnimals
  12. DiNatale RG, Gorelick AN, Makarov V, Blum KA, Silagy AW, Freeman B, Chowell D, Marcon J, Mano R, Sanchez A, Attalla K, Weng S, Voss M, Motzer RJ, Russo P, Coleman JA, Reuter VE, Chen YB, Chan TA, Reznik E, Tickoo SK, Hakimi AA. Putative Drivers of Aggressiveness in TCEB1-mutant Renal Cell Carcinoma: An Emerging Entity with Variable Clinical Course. Eur Urol Focus. 2021 03; 7(2):381-389. PMID: 31813809; PMCID: PMC7274909.
    Citations: 13
    Fields: UroUrologyTranslation:Humans
  13. Smyth LM, Piha-Paul SA, Won HH, Schram AM, Saura C, Loi S, Lu J, Shapiro GI, Juric D, Mayer IA, Arteaga CL, de la Fuente MI, Brufksy AM, Spanggaard I, Mau-Sørensen M, Arnedos M, Moreno V, Boni V, Sohn J, Schwartzberg LS, Gonzàlez-Farré X, Cervantes A, Bidard FC, Gorelick AN, Lanman RB, Nagy RJ, Ulaner GA, Chandarlapaty S, Jhaveri K, Gavrila EI, Zimel C, Selcuklu SD, Melcer M, Samoila A, Cai Y, Scaltriti M, Mann G, Xu F, Eli LD, Dujka M, Lalani AS, Bryce R, Baselga J, Taylor BS, Solit DB, Meric-Bernstam F, Hyman DM. Efficacy and Determinants of Response to HER Kinase Inhibition in HER2-Mutant Metastatic Breast Cancer. Cancer Discov. 2020 02; 10(2):198-213. PMID: 31806627; PMCID: PMC7007377.
    Citations: 61
    Fields: NeoNeoplasmsTranslation:HumansCellsCTClinical Trials
  14. Vasan N, Razavi P, Johnson JL, Shao H, Shah H, Antoine A, Ladewig E, Gorelick A, Lin TY, Toska E, Xu G, Kazmi A, Chang MT, Taylor BS, Dickler MN, Jhaveri K, Chandarlapaty S, Rabadan R, Reznik E, Smith ML, Sebra R, Schimmoller F, Wilson TR, Friedman LS, Cantley LC, Scaltriti M, Baselga J. Double PIK3CA mutations in cis increase oncogenicity and sensitivity to PI3Ka inhibitors. Science. 2019 11 08; 366(6466):714-723. PMID: 31699932; PMCID: PMC7173400.
    Citations: 135
    Fields: SciScienceTranslation:HumansCells
  15. Taylor J, Sendino M, Gorelick AN, Pastore A, Chang MT, Penson AV, Gavrila EI, Stewart C, Melnik EM, Herrejon Chavez F, Bitner L, Yoshimi A, Lee SC, Inoue D, Liu B, Zhang XJ, Mato AR, Dogan A, Kharas MG, Chen Y, Wang D, Soni RK, Hendrickson RC, Prieto G, Rodriguez JA, Taylor BS, Abdel-Wahab O. Altered Nuclear Export Signal Recognition as a Driver of Oncogenesis. Cancer Discov. 2019 10; 9(10):1452-1467. PMID: 31285298; PMCID: PMC6774834.
    Citations: 47
    Fields: NeoNeoplasmsTranslation:HumansAnimalsCells
  16. Gao Y, Maria A, Na N, da Cruz Paula A, Gorelick AN, Hechtman JF, Carson J, Lefkowitz RA, Weigelt B, Taylor BS, Zhao H, Reis-Filho JS, de Stanchina E, Rosen N, Yao Z, Yaeger R. V211D Mutation in MEK1 Causes Resistance to MEK Inhibitors in Colon Cancer. Cancer Discov. 2019 09; 9(9):1182-1191. PMID: 31227518.
    Citations: 22
    Fields: NeoNeoplasmsTranslation:HumansAnimalsCells
  17. Bielski CM, Donoghue MTA, Gadiya M, Hanrahan AJ, Won HH, Chang MT, Jonsson P, Penson AV, Gorelick A, Harris C, Schram AM, Syed A, Zehir A, Chapman PB, Hyman DM, Solit DB, Shannon K, Chandarlapaty S, Berger MF, Taylor BS. Widespread Selection for Oncogenic Mutant Allele Imbalance in Cancer. Cancer Cell. 2018 11 12; 34(5):852-862.e4. PMID: 30393068; PMCID: PMC6234065.
    Citations: 52
    Fields: NeoNeoplasmsTranslation:HumansCells
  18. Chang MT, Bhattarai TS, Schram AM, Bielski CM, Donoghue MTA, Jonsson P, Chakravarty D, Phillips S, Kandoth C, Penson A, Gorelick A, Shamu T, Patel S, Harris C, Gao J, Sumer SO, Kundra R, Razavi P, Li BT, Reales DN, Socci ND, Jayakumaran G, Zehir A, Benayed R, Arcila ME, Chandarlapaty S, Ladanyi M, Schultz N, Baselga J, Berger MF, Rosen N, Solit DB, Hyman DM, Taylor BS. Accelerating Discovery of Functional Mutant Alleles in Cancer. Cancer Discov. 2018 02; 8(2):174-183. PMID: 29247016; PMCID: PMC5809279.
    Citations: 199
    Fields: NeoNeoplasmsTranslation:Humans
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© 2025 President and Fellows of Harvard College
Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.