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profileElizabeth L. Hohmann, M.D.

TitleAssociate Professor of Medicine
InstitutionMassachusetts General Hospital
DepartmentMedicine
AddressMassachusetts General Hospital
Infectious Disease Unit-Gray J504
55 Fruit St
Boston MA 02114
Phone617/724-7532
Fax617/724-3761
vCardDownload vCard (login for email)

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Collapse research activities and funding
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
S07TW008838     (HOHMANN, ELIZABETH L.)Sep 15, 2010 - Sep 14, 2012
NIH/FIC
Collaborative IRB Review and Ethical/Educational Exchange - Boston/Durban
Role: Principal Investigator

R01AI067103     (HOHMANN, ELIZABETH L.)Jul 1, 2005 - Jun 30, 2010
NIH/NIAID
Human Studies of Attenuated Salmonella Vectors
Role: Principal Investigator

R01AI051206     (HOHMANN, ELIZABETH L.)Jun 15, 2002 - May 31, 2010
NIH/NIAID
Human studies of Listeria monocytogenes vectors
Role: Principal Investigator

R01AI045137     (HOHMANN, ELIZABETH L.)Apr 15, 1999 - Mar 31, 2005
NIH/NIAID
PHOP/PHOQ DELETED S TYPHI VACCINE STRAINS
Role: Principal Investigator

R29AI040572     (HOHMANN, ELIZABETH L.)Aug 1, 1997 - Jul 31, 2002
NIH/NIAID
DELETED PHOP/PHOQ S TYPHI AS A LIVE ORAL VACCINE VECTOR
Role: Principal Investigator

Collapse Bibliographic 
Collapse selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Moss EL, Falconer SB, Tkachenko E, Wang M, Systrom H, Mahabamunuge J, Relman DA, Hohmann EL, Bhatt AS. Long-term taxonomic and functional divergence from donor bacterial strains following fecal microbiota transplantation in immunocompromised patients. PLoS One. 2017; 12(8):e0182585. PMID: 28827811.
    View in: PubMed
  2. Andrews JR, Vaidya K, Bern C, Tamrakar D, Wen S, Madhup S, Shrestha R, Karmacharya B, Amatya B, Koju R, Adhikari SR, Hohmann E, Ryan ET, Bogoch II. High Rates of Enteric Fever Diagnosis and Lower Burden of Culture-Confirmed Disease in Peri-urban and Rural Nepal. J Infect Dis. 2017 Jul 28. PMID: 28961918.
    View in: PubMed
  3. Adelman MW, Johnson JH, Hohmann EL, Gandhi RT. Ovarian Endometrioma Superinfected With Salmonella: Case Report and Review of the Literature. Open Forum Infect Dis. 2017; 4(2):ofx048. PMID: 28470024.
    View in: PubMed
  4. Chin SM, Sauk J, Mahabamunuge J, Kaplan JL, Hohmann EL, Khalili H. Fecal Microbiota Transplantation for Recurrent Clostridium difficile Infection in Patients With Inflammatory Bowel Disease: A Single-Center Experience. Clin Gastroenterol Hepatol. 2017 Apr; 15(4):597-599. PMID: 27923723.
    View in: PubMed
  5. Khanna S, Button JE, Lombardo MJ, Vulic M, Henn MR, Cook DN, Pomerantz RJ, Hohmann EL. Reply to Lagier et al. J Infect Dis. 2017 Jan 01; 215(1):162-164. PMID: 28077592.
    View in: PubMed
  6. Youngster I, Mahabamunuge J, Systrom HK, Sauk J, Khalili H, Levin J, Kaplan JL, Hohmann EL. Oral, frozen fecal microbiota transplant (FMT) capsules for recurrent Clostridium difficile infection. BMC Med. 2016 Sep 09; 14(1):134. PMID: 27609178; PMCID: PMC5016994.
  7. Hohmann EL. Are Microbial Politics Local? Ann Intern Med. 2016 Nov 01; 165(9):667-668. PMID: 27548329.
    View in: PubMed
  8. Bashan A, Gibson TE, Friedman J, Carey VJ, Weiss ST, Hohmann EL, Liu YY. Universality of human microbial dynamics. Nature. 2016 06 09; 534(7606):259-62. PMID: 27279224; PMCID: PMC4902290 [Available on 12/08/16].
  9. Boutin NT, Mathieu K, Hoffnagle AG, Allen NL, Castro VM, Morash M, O'Rourke PP, Hohmann EL, Herring N, Bry L, Slaugenhaupt SA, Karlson EW, Weiss ST, Smoller JW. Implementation of Electronic Consent at a Biobank: An Opportunity for Precision Medicine Research. J Pers Med. 2016 Jun 09; 6(2). PMID: 27294961; PMCID: PMC4932464.
  10. Khanna S, Pardi DS, Kelly CR, Kraft CS, Dhere T, Henn MR, Lombardo MJ, Vulic M, Ohsumi T, Winkler J, Pindar C, McGovern BH, Pomerantz RJ, Aunins JG, Cook DN, Hohmann EL. A Novel Microbiome Therapeutic Increases Gut Microbial Diversity and Prevents Recurrent Clostridium difficile Infection. J Infect Dis. 2016 Jul 15; 214(2):173-81. PMID: 26908752.
    View in: PubMed
  11. Youngster I, Hohmann EL. Fecal microbiota transplantation for Clostridium difficile infection--reply. JAMA. 2015 Feb 17; 313(7):726. PMID: 25688788.
    View in: PubMed
  12. Weil AA, Hohmann EL. Fecal microbiota transplant: benefits and risks. Open Forum Infect Dis. 2015 Jan; 2(1):ofv005. PMID: 26034756; PMCID: PMC4438886.
  13. Hohmann EL. Case 25-2014: A man with ulcerative colitis and bloody diarrhea. N Engl J Med. 2014 Nov 06; 371(19):1848-9. PMID: 25372107.
    View in: PubMed
  14. Youngster I, Russell GH, Pindar C, Ziv-Baran T, Sauk J, Hohmann EL. Oral, capsulized, frozen fecal microbiota transplantation for relapsing Clostridium difficile infection. JAMA. 2014 Nov 05; 312(17):1772-8. PMID: 25322359.
    View in: PubMed
  15. Hohmann EL, Ananthakrishnan AN, Deshpande V. Case Records of the Massachusetts General Hospital. Case 25-2014. A 37-year-old man with ulcerative colitis and bloody diarrhea. N Engl J Med. 2014 Aug 14; 371(7):668-75. PMID: 25119613.
    View in: PubMed
  16. Kelly CR, Ihunnah C, Fischer M, Khoruts A, Surawicz C, Afzali A, Aroniadis O, Barto A, Borody T, Giovanelli A, Gordon S, Gluck M, Hohmann EL, Kao D, Kao JY, McQuillen DP, Mellow M, Rank KM, Rao K, Ray A, Schwartz MA, Singh N, Stollman N, Suskind DL, Vindigni SM, Youngster I, Brandt L. Fecal microbiota transplant for treatment of Clostridium difficile infection in immunocompromised patients. Am J Gastroenterol. 2014 Jul; 109(7):1065-71. PMID: 24890442.
    View in: PubMed
  17. Russell GH, Kaplan JL, Youngster I, Baril-Dore M, Schindelar L, Hohmann E, Winter HS. Fecal transplant for recurrent Clostridium difficile infection in children with and without inflammatory bowel disease. J Pediatr Gastroenterol Nutr. 2014 May; 58(5):588-92. PMID: 24792627.
    View in: PubMed
  18. Youngster I, Sauk J, Pindar C, Wilson RG, Kaplan JL, Smith MB, Alm EJ, Gevers D, Russell GH, Hohmann EL. Fecal microbiota transplant for relapsing Clostridium difficile infection using a frozen inoculum from unrelated donors: a randomized, open-label, controlled pilot study. Clin Infect Dis. 2014 Jun; 58(11):1515-22. PMID: 24762631; PMCID: PMC4017893.
  19. Malo MS, Moaven O, Muhammad N, Biswas B, Alam SN, Economopoulos KP, Gul SS, Hamarneh SR, Malo NS, Teshager A, Mohamed MM, Tao Q, Narisawa S, Millán JL, Hohmann EL, Warren HS, Robson SC, Hodin RA. Intestinal alkaline phosphatase promotes gut bacterial growth by reducing the concentration of luminal nucleotide triphosphates. Am J Physiol Gastrointest Liver Physiol. 2014 May 15; 306(10):G826-38. PMID: 24722905; PMCID: PMC4024727.
  20. Andrews JR, Prajapati KG, Eypper E, Shrestha P, Shakya M, Pathak KR, Joshi N, Tiwari P, Risal M, Koirala S, Karkey A, Dongol S, Wen S, Smith AB, Maru D, Basnyat B, Baker S, Farrar J, Ryan ET, Hohmann E, Arjyal A. Evaluation of an electricity-free, culture-based approach for detecting typhoidal Salmonella bacteremia during enteric fever in a high burden, resource-limited setting. PLoS Negl Trop Dis. 2013; 7(6):e2292. PMID: 23853696; PMCID: PMC3694822.
  21. Eypper EH, Johnson PV, Purro EI, Hohmann EL. Transcutaneous immunization of healthy volunteers with an attenuated Listeria monocytogenes vaccine strain and cholera toxin adjuvant. Vaccine. 2013 Jul 11; 31(32):3257-61. PMID: 23707162; PMCID: PMC3831363.
  22. Chan BT, Hohmann E, Barshak MB, Pukkila-Worley R. Treatment of listeriosis in first trimester of pregnancy. Emerg Infect Dis. 2013 May; 19(5):839-41. PMID: 23697599; PMCID: PMC3647505.
  23. Kaliannan K, Hamarneh SR, Economopoulos KP, Nasrin Alam S, Moaven O, Patel P, Malo NS, Ray M, Abtahi SM, Muhammad N, Raychowdhury A, Teshager A, Mohamed MM, Moss AK, Ahmed R, Hakimian S, Narisawa S, Millán JL, Hohmann E, Warren HS, Bhan AK, Malo MS, Hodin RA. Intestinal alkaline phosphatase prevents metabolic syndrome in mice. Proc Natl Acad Sci U S A. 2013 Apr 23; 110(17):7003-8. PMID: 23569246; PMCID: PMC3637741.
  24. Keune JD, Brunsvold ME, Hohmann E, Korndorffer JR, Weinstein DF, Smink DS. The ethics of conducting graduate medical education research on residents. Acad Med. 2013 Apr; 88(4):449-53. PMID: 23425981.
    View in: PubMed
  25. Moss AK, Hamarneh SR, Mohamed MM, Ramasamy S, Yammine H, Patel P, Kaliannan K, Alam SN, Muhammad N, Moaven O, Teshager A, Malo NS, Narisawa S, Millán JL, Warren HS, Hohmann E, Malo MS, Hodin RA. Intestinal alkaline phosphatase inhibits the proinflammatory nucleotide uridine diphosphate. Am J Physiol Gastrointest Liver Physiol. 2013 Mar 15; 304(6):G597-604. PMID: 23306083; PMCID: PMC3602687.
  26. Bogoch II, Andrews JR, Zachary KC, Hohmann EL. Diagnosis of influenza from lower respiratory tract sampling after negative upper respiratory tract sampling. Virulence. 2013 Jan 01; 4(1):82-4. PMID: 23135351; PMCID: PMC3544752.
  27. Hohmann EL, Kim J. Case records of the Massachusetts General Hospital. Case 8-2012. A 53-year-old man with Crohn's disease, diarrhea, fever, and bacteremia. N Engl J Med. 2012 Mar 15; 366(11):1039-45. PMID: 22417258.
    View in: PubMed
  28. Sheikh A, Charles RC, Sharmeen N, Rollins SM, Harris JB, Bhuiyan MS, Arifuzzaman M, Khanam F, Bukka A, Kalsy A, Porwollik S, Leung DT, Brooks WA, LaRocque RC, Hohmann EL, Cravioto A, Logvinenko T, Calderwood SB, McClelland M, Graham JE, Qadri F, Ryan ET. In vivo expression of Salmonella enterica serotype Typhi genes in the blood of patients with typhoid fever in Bangladesh. PLoS Negl Trop Dis. 2011 Dec; 5(12):e1419. PMID: 22180799; PMCID: PMC3236720.
  29. Bogoch II, Andrews JR, Hohmann EL, Kotton CN, Marty FM. Pandemic H1N1 influenza infection in adult transplant recipients. Transplantation. 2011 Jun 27; 91(12):e80-1. PMID: 21654492.
    View in: PubMed
  30. Johnson PV, Blair BM, Zeller S, Kotton CN, Hohmann EL. Attenuated Listeria monocytogenes vaccine vectors expressing influenza A nucleoprotein: preclinical evaluation and oral inoculation of volunteers. Microbiol Immunol. 2011 May; 55(5):304-17. PMID: 21338384; PMCID: PMC3082616.
  31. Bogoch II, Andrews JR, Marty FM, Hohmann EL. HIV-1 and 2009 H1N1 influenza A in adults. J Acquir Immune Defic Syndr. 2011 Apr; 56(4):e111-3. PMID: 21350357.
    View in: PubMed
  32. Ebrahimi F, Malo MS, Alam SN, Moss AK, Yammine H, Ramasamy S, Biswas B, Chen KT, Muhammad N, Mostafa G, Warren HS, Hohmann EL, Hodin RA. Local peritoneal irrigation with intestinal alkaline phosphatase is protective against peritonitis in mice. J Gastrointest Surg. 2011 May; 15(5):860-9. PMID: 21360208.
    View in: PubMed
  33. Ramasamy S, Nguyen DD, Eston MA, Alam SN, Moss AK, Ebrahimi F, Biswas B, Mostafa G, Chen KT, Kaliannan K, Yammine H, Narisawa S, Millán JL, Warren HS, Hohmann EL, Mizoguchi E, Reinecker HC, Bhan AK, Snapper SB, Malo MS, Hodin RA. Intestinal alkaline phosphatase has beneficial effects in mouse models of chronic colitis. Inflamm Bowel Dis. 2011 Feb; 17(2):532-42. PMID: 20645323; PMCID: PMC3154118.
  34. Sheikh A, Charles RC, Rollins SM, Harris JB, Bhuiyan MS, Khanam F, Bukka A, Kalsy A, Porwollik S, Brooks WA, LaRocque RC, Hohmann EL, Cravioto A, Logvinenko T, Calderwood SB, McClelland M, Graham JE, Qadri F, Ryan ET. Analysis of Salmonella enterica serotype paratyphi A gene expression in the blood of bacteremic patients in Bangladesh. PLoS Negl Trop Dis. 2010 Dec 07; 4(12):e908. PMID: 21151879; PMCID: PMC2998432.
  35. Malo MS, Alam SN, Mostafa G, Zeller SJ, Johnson PV, Mohammad N, Chen KT, Moss AK, Ramasamy S, Faruqui A, Hodin S, Malo PS, Ebrahimi F, Biswas B, Narisawa S, Millán JL, Warren HS, Kaplan JB, Kitts CL, Hohmann EL, Hodin RA. Intestinal alkaline phosphatase preserves the normal homeostasis of gut microbiota. Gut. 2010 Nov; 59(11):1476-84. PMID: 20947883.
    View in: PubMed
  36. Chen KT, Malo MS, Beasley-Topliffe LK, Poelstra K, Millan JL, Mostafa G, Alam SN, Ramasamy S, Warren HS, Hohmann EL, Hodin RA. A role for intestinal alkaline phosphatase in the maintenance of local gut immunity. Dig Dis Sci. 2011 Apr; 56(4):1020-7. PMID: 20844955; PMCID: PMC3931260.
  37. Chen KT, Malo MS, Moss AK, Zeller S, Johnson P, Ebrahimi F, Mostafa G, Alam SN, Ramasamy S, Warren HS, Hohmann EL, Hodin RA. Identification of specific targets for the gut mucosal defense factor intestinal alkaline phosphatase. Am J Physiol Gastrointest Liver Physiol. 2010 Aug; 299(2):G467-75. PMID: 20489044; PMCID: PMC2928538.
  38. Nurok M, Eslick I, Carvalho CR, Costabel U, D'Armiento J, Glanville AR, Harari S, Henske EP, Inoue Y, Johnson SR, Lacronique J, Lazor R, Moss J, Ruoss SJ, Ryu JH, Seyama K, Watz H, Xu KF, Hohmann EL, Moss F. The International LAM Registry: a component of an innovative web-based clinician, researcher, and patient-driven rare disease research platform. Lymphat Res Biol. 2010 Mar; 8(1):81-7. PMID: 20235890.
    View in: PubMed
  39. Charles RC, Harris JB, Chase MR, Lebrun LM, Sheikh A, LaRocque RC, Logvinenko T, Rollins SM, Tarique A, Hohmann EL, Rosenberg I, Krastins B, Sarracino DA, Qadri F, Calderwood SB, Ryan ET. Comparative proteomic analysis of the PhoP regulon in Salmonella enterica serovar Typhi versus Typhimurium. PLoS One. 2009 Sep 10; 4(9):e6994. PMID: 19746165; PMCID: PMC2736619.
  40. Hohmann EL. Gene therapy--still a work in clinical and regulatory progress. N Engl J Med. 2009 Jul 09; 361(2):193-5. PMID: 19587346.
    View in: PubMed
  41. Lankowski AJ, Hohmann EL. Killed but metabolically active Salmonella typhimurium: application of a new technology to an old vector. J Infect Dis. 2007 Apr 15; 195(8):1203-11. PMID: 17357059.
    View in: PubMed
  42. Vyas JM, Kasmar A, Chang HR, Holden J, Hohmann E. Abdominal abscesses due to actinomycosis after laparoscopic cholecystectomy: case reports and review. Clin Infect Dis. 2007 Jan 15; 44(2):e1-4. PMID: 17173208.
    View in: PubMed
  43. Harris JB, Baresch-Bernal A, Rollins SM, Alam A, LaRocque RC, Bikowski M, Peppercorn AF, Handfield M, Hillman JD, Qadri F, Calderwood SB, Hohmann E, Breiman RF, Brooks WA, Ryan ET. Identification of in vivo-induced bacterial protein antigens during human infection with Salmonella enterica serovar Typhi. Infect Immun. 2006 Sep; 74(9):5161-8. PMID: 16926408; PMCID: PMC1594849.
  44. Hohmann E, Tetsworth K, Radziejowski MJ, Wiesniewski TF. Comparison of delayed and primary wound closure in the treatment of open tibial fractures. Arch Orthop Trauma Surg. 2007 Feb; 127(2):131-6. PMID: 16944234.
    View in: PubMed
  45. Kotton CN, Lankowski AJ, Scott N, Sisul D, Chen LM, Raschke K, Borders G, Boaz M, Spentzou A, Galán JE, Hohmann EL. Safety and immunogenicity of attenuated Salmonella enterica serovar Typhimurium delivering an HIV-1 Gag antigen via the Salmonella Type III secretion system. Vaccine. 2006 Sep 11; 24(37-39):6216-24. PMID: 16824652.
    View in: PubMed
  46. Kotton CN, Lankowski AJ, Hohmann EL. Comparison of rectal swabs with fecal cultures for detection of Salmonella typhimurium in adult volunteers. Diagn Microbiol Infect Dis. 2006 Oct; 56(2):123-6. PMID: 16725299.
    View in: PubMed
  47. Hohmann E, Woodson J. "Inefficient, arbitrary, inconsistent": a frank look at how some investigators view IRBs and a few suggestions for improvement. Prot Hum Subj. 2005; (12):12-4. PMID: 16317859.
    View in: PubMed
  48. Kotton CN, Hohmann EL. Enteric pathogens as vaccine vectors for foreign antigen delivery. Infect Immun. 2004 Oct; 72(10):5535-47. PMID: 15385450; PMCID: PMC517600.
  49. Ali T, Scott N, Kallas W, Halliwell ME, Savino C, Rosenberg E, Ferraro M, Hohmann E. Detection of influenza antigen with rapid antibody-based tests after intranasal influenza vaccination (FluMist). Clin Infect Dis. 2004 Mar 01; 38(5):760-2. PMID: 14986264.
    View in: PubMed
  50. Mylonakis E, Paliou M, Hohmann EL, Calderwood SB, Wing EJ. Listeriosis during pregnancy: a case series and review of 222 cases. Medicine (Baltimore). 2002 Jul; 81(4):260-9. PMID: 12169881.
    View in: PubMed
  51. Angelakopoulos H, Loock K, Sisul DM, Jensen ER, Miller JF, Hohmann EL. Safety and shedding of an attenuated strain of Listeria monocytogenes with a deletion of actA/plcB in adult volunteers: a dose escalation study of oral inoculation. Infect Immun. 2002 Jul; 70(7):3592-601. PMID: 12065500; PMCID: PMC128066.
  52. Hohmann EL. Nontyphoidal salmonellosis. Clin Infect Dis. 2001 Jan 15; 32(2):263-9. PMID: 11170916.
    View in: PubMed
  53. Angelakopoulos H, Hohmann EL. Pilot study of phoP/phoQ-deleted Salmonella enterica serovar typhimurium expressing Helicobacter pylori urease in adult volunteers. Infect Immun. 2000 Apr; 68(4):2135-41. PMID: 10722611; PMCID: PMC97395.
  54. DiPetrillo MD, Tibbetts T, Kleanthous H, Killeen KP, Hohmann EL. Safety and immunogenicity of phoP/phoQ-deleted Salmonella typhi expressing Helicobacter pylori urease in adult volunteers. Vaccine. 1999 Oct 14; 18(5-6):449-59. PMID: 10519934.
    View in: PubMed
  55. VanCott JL, Chatfield SN, Roberts M, Hone DM, Hohmann EL, Pascual DW, Yamamoto M, Kiyono H, McGhee JR. Regulation of host immune responses by modification of Salmonella virulence genes. Nat Med. 1998 Nov; 4(11):1247-52. PMID: 9809547.
    View in: PubMed
  56. Mylonakis E, Hohmann EL, Calderwood SB. Central nervous system infection with Listeria monocytogenes. 33 years' experience at a general hospital and review of 776 episodes from the literature. Medicine (Baltimore). 1998 Sep; 77(5):313-36. PMID: 9772921.
    View in: PubMed
  57. Gunn JS, Hohmann EL, Miller SI. Transcriptional regulation of Salmonella virulence: a PhoQ periplasmic domain mutation results in increased net phosphotransfer to PhoP. J Bacteriol. 1996 Nov; 178(21):6369-73. PMID: 8892844; PMCID: PMC178515.
  58. Hohmann EL, Oletta CA, Killeen KP, Miller SI. phoP/phoQ-deleted Salmonella typhi (Ty800) is a safe and immunogenic single-dose typhoid fever vaccine in volunteers. J Infect Dis. 1996 Jun; 173(6):1408-14. PMID: 8648213.
    View in: PubMed
  59. Hohmann EL, Oletta CA, Miller SI. Evaluation of a phoP/phoQ-deleted, aroA-deleted live oral Salmonella typhi vaccine strain in human volunteers. Vaccine. 1996 Jan; 14(1):19-24. PMID: 8821644.
    View in: PubMed
  60. Hohmann EL, Oletta CA, Loomis WP, Miller SI. Macrophage-inducible expression of a model antigen in Salmonella typhimurium enhances immunogenicity. Proc Natl Acad Sci U S A. 1995 Mar 28; 92(7):2904-8. PMID: 7708746; PMCID: PMC42327.
  61. Miller SI, Loomis WP, Alpuche-Aranda C, Behlau I, Hohmann E. The PhoP virulence regulon and live oral Salmonella vaccines. Vaccine. 1993; 11(2):122-5. PMID: 8438611.
    View in: PubMed
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