Harvard Catalyst Profiles

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Wei Hsu, Ph.D.

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Mount Sinai School of Medicine of CUNY, New York CityM.Ph.05/1992Biomedical Sciences
Mount Sinai School of Medicine of CUNY, New York CityPh.D.05/1994Biomedical Sciences
Columbia University - College of Physicians and Surgeons, New York CityPostdoctoral Fellow04/1997Genetics & Developmental Biology
1989 - 1994
Predoctoral Fellowship
1992 - 1993
Traveling & Research Award
1995 - 1997
Postdoctoral fellowship
Research Award, Northeast Regional Conference
2007 - 2010
Idea Award
Distinguished Alumnus
Pathways to Excellence Visiting Professorship
Senior Author/Mentor for the 2013 ASBMR Raisz-Drezner Award
Dean’s Professorship/Endowed Chair
Mentor for ASBMR Harold M. Frost Young Investigator Award
Nominee for AAAS Fellow

Morphogenetic Signaling Network in Development and Disease:
We are interested in the mechanisms that support embryonic morphogenesis, tissue homeostasis, disease pathogenesis, and organ repair and regeneration. Focusing initially on Wnt as one of the most prevalent signaling pathways in developmental biology, we are establishing how Wnt signaling and its crosstalk with other pathways control pluripotency and differentiation in stem cells and homeostasis in mature cells. More recently, we have also focused on epigenetic, post-translational, ciliogenesis, mitochondrial regulation, and nuclear lamina causally linked to human diseases. Our goal is to use this basic knowledge to develop innovative strategies for disease prevention and therapy.

Skeletal Tissue Engineering [login at prompt]
Available: 01/01/00, Expires: 03/01/24

The primary objective of this project is to develop next-generation therapeutics for skeletal disease and injury through bone and cartilage reconstruction. Our goal is to establish guided bone ossification and cartilage formation by bio-print stem cell-laden hydrogels with well-controlled three-dimensional geometrical, mechanical, chemical, and biological properties. The biomaterials will be evaluated by ex vivo analyses and in vivo transplantation studies in mouse injury models for skeletal regeneration. The results obtained from these preclinical animal studies will be used to improve and upgrade the biomaterials for bone and cartilage tissue engineering. Students will use a 3D printer to print 3D objects from a computer-aided design (CAD), as well as learn how to modify an existing 3D printer to bio-print cell-laden hydrogels. They will also acquire skills in stem cell analyses. The project requires an interest and previous experience in the research area of skeletal biology, stem cell therapy, 3D-printers, specially fused deposition modeling (FDM) 3D-printers, capable of setting up instruments, using Repetier and CAD software.

Available: 01/01/00, Expires: 03/01/24

Looking for motivated students interested in Data Science/Bioinformatics and participating in a team effort with the potential to publish papers in high-profile journals. Relevant courses or backgrounds in statistics, programming (R language, MetaCore), and basic biology are required for this position. The specific study includes data mining of single-cell RNA-sequencing and bulk RNA-sequencing. The single-cell RNA-sequencing project investigates a recent discovery of skeletal stem cell population. By examining its transcriptomic diversity and relevant cellular heterogeneity, our goal is to identify a subpopulation with elevated expression of skeletal stem cell markers and genes linked to patients with congenital deformities, as well as to reveal novel regulatory processes of cell lineage development between the stem cell-enriched subpopulation and other subpopulations. For bulk RNA-sequencing projects, our strategy is to identify differentially expressed genes (DEGs) affected by the gene mutation in mouse models, followed by Gene Set Enrichment Analysis, Pathway Analysis, and Upstream Regulator Assay using MetaCore or relevant software. Using these data minings, our goal is to identify candidates processing dynamic effects on phenotypic alteration in the mouse models.

The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. 7R01DE015654-14 (HSU, WEI) Jul 1, 2021 - Jan 31, 2024
    Change of Grantee Organization
    Role: Principal Investigator
  2. 7R01DE026936-04 (HSU, WEI) Jun 30, 2021 - May 31, 2023
    Stem cells for craniofacial bone repair and regeneration
    Role: Principal Investigator
  3. 7R21DE028696-03 (MARUYAMA, TAKAMITSU) Jun 17, 2021 - Mar 31, 2022
    The essential role of miR-27a in craniofacial and body skeletons
    Role: Co-Investigator
  4. R21DE028696 (MARUYAMA, TAKAMITSU) Apr 1, 2019 - Mar 31, 2021
    The essential role of miR-27a in craniofacial and body skeletons.
    Role: Co-Investigator
  5. R01DE026936 (HSU, WEI) Jun 1, 2018 - May 31, 2023
    Stem cells for craniofacial bone repair and regeneration
    Role: Principal Investigator
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.