Harvard Catalyst Profiles

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Michael Cleary, M.D.

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Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Duque-Afonso J, Lin CH, Han K, Morgens DW, Jeng EE, Weng Z, Jeong J, Wong SHK, Zhu L, Wei MC, Chae HD, Schrappe M, Cario G, Duyster J, Xiao X, Sakamoto KM, Bassik MC, Cleary ML. CBP Modulates Sensitivity to Dasatinib in Pre-BCR+ Acute Lymphoblastic Leukemia. Cancer Res. 2018 11 15; 78(22):6497-6508. PMID: 30262461.
    Citations: 2     Fields:    Translation:HumansCells
  2. Zhu L, Li Q, Wong SH, Huang M, Klein BJ, Shen J, Ikenouye L, Onishi M, Schneidawind D, Buechele C, Hansen L, Duque-Afonso J, Zhu F, Martin GM, Gozani O, Majeti R, Kutateladze TG, Cleary ML. ASH1L Links Histone H3 Lysine 36 Dimethylation to MLL Leukemia. Cancer Discov. 2016 07; 6(7):770-83. PMID: 27154821.
    Citations: 46     Fields:    Translation:HumansAnimalsCells
  3. Iwasaki M, Liedtke M, Gentles AJ, Cleary ML. CD93 Marks a Non-Quiescent Human Leukemia Stem Cell Population and Is Required for Development of MLL-Rearranged Acute Myeloid Leukemia. Cell Stem Cell. 2015 Oct 01; 17(4):412-21. PMID: 26387756.
    Citations: 34     Fields:    Translation:HumansCells
  4. Wong SH, Goode DL, Iwasaki M, Wei MC, Kuo HP, Zhu L, Schneidawind D, Duque-Afonso J, Weng Z, Cleary ML. The H3K4-Methyl Epigenome Regulates Leukemia Stem Cell Oncogenic Potential. Cancer Cell. 2015 Aug 10; 28(2):198-209. PMID: 26190263.
    Citations: 43     Fields:    Translation:HumansAnimalsCells
  5. Aikawa Y, Yamagata K, Katsumoto T, Shima Y, Shino M, Stanley ER, Cleary ML, Akashi K, Tenen DG, Kitabayashi I. Essential role of PU.1 in maintenance of mixed lineage leukemia-associated leukemic stem cells. Cancer Sci. 2015 Mar; 106(3):227-36. PMID: 25529853.
    Citations: 8     Fields:    Translation:AnimalsCells
  6. Duque-Afonso J, Cleary ML. The AML salad bowl. Cancer Cell. 2014 Mar 17; 25(3):265-7. PMID: 24651007.
    Citations: 8     Fields:    Translation:HumansAnimals
  7. Kuo HP, Wang Z, Lee DF, Iwasaki M, Duque-Afonso J, Wong SH, Lin CH, Figueroa ME, Su J, Lemischka IR, Cleary ML. Epigenetic roles of MLL oncoproteins are dependent on NF-?B. Cancer Cell. 2013 Oct 14; 24(4):423-37. PMID: 24054986.
    Citations: 42     Fields:    Translation:HumansAnimalsCells
  8. Heuser M, Yun H, Berg T, Yung E, Argiropoulos B, Kuchenbauer F, Park G, Hamwi I, Palmqvist L, Lai CK, Leung M, Lin G, Chaturvedi A, Thakur BK, Iwasaki M, Bilenky M, Thiessen N, Robertson G, Hirst M, Kent D, Wilson NK, Göttgens B, Eaves C, Cleary ML, Marra M, Ganser A, Humphries RK. Cell of origin in AML: susceptibility to MN1-induced transformation is regulated by the MEIS1/AbdB-like HOX protein complex. Cancer Cell. 2011 Jul 12; 20(1):39-52. PMID: 21741595.
    Citations: 44     Fields:    Translation:HumansAnimalsCells
  9. Wang Z, Iwasaki M, Ficara F, Lin C, Matheny C, Wong SH, Smith KS, Cleary ML. GSK-3 promotes conditional association of CREB and its coactivators with MEIS1 to facilitate HOX-mediated transcription and oncogenesis. Cancer Cell. 2010 Jun 15; 17(6):597-608. PMID: 20541704.
    Citations: 64     Fields:    Translation:HumansAnimalsCells
  10. Chang PY, Hom RA, Musselman CA, Zhu L, Kuo A, Gozani O, Kutateladze TG, Cleary ML. Binding of the MLL PHD3 finger to histone H3K4me3 is required for MLL-dependent gene transcription. J Mol Biol. 2010 Jul 09; 400(2):137-44. PMID: 20452361.
    Citations: 44     Fields:    Translation:HumansAnimalsCells
  11. Liedtke M, Ayton PM, Somervaille TC, Smith KS, Cleary ML. Self-association mediated by the Ras association 1 domain of AF6 activates the oncogenic potential of MLL-AF6. Blood. 2010 Jul 08; 116(1):63-70. PMID: 20395419.
    Citations: 15     Fields:    Translation:HumansAnimalsCells
  12. Yokoyama A, Lin M, Naresh A, Kitabayashi I, Cleary ML. A higher-order complex containing AF4 and ENL family proteins with P-TEFb facilitates oncogenic and physiologic MLL-dependent transcription. Cancer Cell. 2010 Feb 17; 17(2):198-212. PMID: 20153263.
    Citations: 168     Fields:    Translation:HumansAnimalsCells
  13. Yokoyama A, Cleary ML. Menin critically links MLL proteins with LEDGF on cancer-associated target genes. Cancer Cell. 2008 Jul 08; 14(1):36-46. PMID: 18598942.
    Citations: 229     Fields:    Translation:HumansAnimalsCells
  14. Somervaille TC, Cleary ML. PU.1 and Junb: suppressing the formation of acute myeloid leukemia stem cells. Cancer Cell. 2006 Dec; 10(6):456-7. PMID: 17157786.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  15. Somervaille TC, Cleary ML. Identification and characterization of leukemia stem cells in murine MLL-AF9 acute myeloid leukemia. Cancer Cell. 2006 Oct; 10(4):257-68. PMID: 17045204.
    Citations: 251     Fields:    Translation:HumansAnimalsCells
  16. Ayton PM, Chen EH, Cleary ML. Binding to nonmethylated CpG DNA is essential for target recognition, transactivation, and myeloid transformation by an MLL oncoprotein. Mol Cell Biol. 2004 Dec; 24(23):10470-8. PMID: 15542854.
    Citations: 71     Fields:    Translation:HumansAnimalsCells
  17. So CW, Karsunky H, Wong P, Weissman IL, Cleary ML. Leukemic transformation of hematopoietic progenitors by MLL-GAS7 in the absence of Hoxa7 or Hoxa9. Blood. 2004 Apr 15; 103(8):3192-9. PMID: 15070702.
    Citations: 61     Fields:    Translation:AnimalsCells
  18. Cozzio A, Passegué E, Ayton PM, Karsunky H, Cleary ML, Weissman IL. Similar MLL-associated leukemias arising from self-renewing stem cells and short-lived myeloid progenitors. Genes Dev. 2003 Dec 15; 17(24):3029-35. PMID: 14701873.
    Citations: 214     Fields:    Translation:HumansAnimalsCells
  19. Ayton PM, Cleary ML. Transformation of myeloid progenitors by MLL oncoproteins is dependent on Hoxa7 and Hoxa9. Genes Dev. 2003 Sep 15; 17(18):2298-307. PMID: 12952893.
    Citations: 174     Fields:    Translation:HumansAnimalsCells
  20. So CW, Lin M, Ayton PM, Chen EH, Cleary ML. Dimerization contributes to oncogenic activation of MLL chimeras in acute leukemias. Cancer Cell. 2003 Aug; 4(2):99-110. PMID: 12957285.
    Citations: 67     Fields:    Translation:HumansAnimalsCells
  21. Kim SA, Vacratsis PO, Firestein R, Cleary ML, Dixon JE. Regulation of myotubularin-related (MTMR)2 phosphatidylinositol phosphatase by MTMR5, a catalytically inactive phosphatase. Proc Natl Acad Sci U S A. 2003 Apr 15; 100(8):4492-7. PMID: 12668758.
    Citations: 47     Fields:    Translation:HumansAnimalsCells
  22. Deguchi K, Ayton PM, Carapeti M, Kutok JL, Snyder CS, Williams IR, Cross NC, Glass CK, Cleary ML, Gilliland DG. MOZ-TIF2-induced acute myeloid leukemia requires the MOZ nucleosome binding motif and TIF2-mediated recruitment of CBP. Cancer Cell. 2003 Mar; 3(3):259-71. PMID: 12676584.
    Citations: 71     Fields:    Translation:HumansAnimalsCells
  23. So CW, Karsunky H, Passegué E, Cozzio A, Weissman IL, Cleary ML. MLL-GAS7 transforms multipotent hematopoietic progenitors and induces mixed lineage leukemias in mice. Cancer Cell. 2003 Feb; 3(2):161-71. PMID: 12620410.
    Citations: 62     Fields:    Translation:HumansAnimalsCells
  24. So CW, Cleary ML. MLL-AFX requires the transcriptional effector domains of AFX to transform myeloid progenitors and transdominantly interfere with forkhead protein function. Mol Cell Biol. 2002 Sep; 22(18):6542-52. PMID: 12192052.
    Citations: 34     Fields:    Translation:HumansAnimalsCells
  25. So CW, Cleary ML. Common mechanism for oncogenic activation of MLL by forkhead family proteins. Blood. 2003 Jan 15; 101(2):633-9. PMID: 12393557.
    Citations: 36     Fields:    Translation:AnimalsCells
  26. Yokoyama A, Kitabayashi I, Ayton PM, Cleary ML, Ohki M. Leukemia proto-oncoprotein MLL is proteolytically processed into 2 fragments with opposite transcriptional properties. Blood. 2002 Nov 15; 100(10):3710-8. PMID: 12393701.
    Citations: 70     Fields:    Translation:HumansCells
  27. DiMartino JF, Ayton PM, Chen EH, Naftzger CC, Young BD, Cleary ML. The AF10 leucine zipper is required for leukemic transformation of myeloid progenitors by MLL-AF10. Blood. 2002 May 15; 99(10):3780-5. PMID: 11986236.
    Citations: 42     Fields:    Translation:AnimalsCells
  28. Nagy PL, Griesenbeck J, Kornberg RD, Cleary ML. A trithorax-group complex purified from Saccharomyces cerevisiae is required for methylation of histone H3. Proc Natl Acad Sci U S A. 2002 Jan 08; 99(1):90-4. PMID: 11752412.
    Citations: 144     Fields:    Translation:AnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.