Profiles Header - Harvard Catalyst Profiles Header – Harvard Catalyst

Harvard Catalyst Profiles

Contact, publication, and social network information about Harvard faculty and fellows.

Andrew B. Lassar, Ph.D.

Title
Institution
Department
Address
Phone
Fax

Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01AR060735 (LASSAR, ANDREW BRUCE) Mar 1, 2013 - Feb 28, 2018
    NIH/NIAMS
    Role of GATA6 in regulating hedgehog signaling in the growth plate
    Role: Principal Investigator
  2. R21AR055148 (LASSAR, ANDREW BRUCE) Sep 27, 2010 - Aug 31, 2012
    NIH/NIAMS
    Fate mapping and signaling pathways of superficial cells in articular cartilage
    Role: Principal Investigator
  3. R01AR055552 (LASSAR, ANDREW BRUCE) Apr 1, 2010 - Mar 31, 2015
    NIH/NIAMS
    Identification of the transcriptional regulators of chondrocyte hypertrophy
    Role: Principal Investigator
  4. R13AR046901 (LASSAR, ANDREW BRUCE) May 1, 2000 - Apr 30, 2001
    NIH/NIAMS
    MOLECULAR BIOLOGY OF MUSCLE DEVELOPMENT AND DIS
    Role: Principal Investigator
  5. P50HL061036 (IZUMO, SEIGO) Jan 1, 1999 - Mar 31, 2004
    NIH/NHLBI
    MOLECULAR MECHANISMS OF CONGENITAL HEART DISEASE
    Role: Co-Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
List All   |   Timeline
  1. Lassar AB. Finding MyoD and lessons learned along the way. Semin Cell Dev Biol. 2017 12; 72:3-9. PMID: 29097153.
    View in: PubMed
  2. Li L, Newton PT, Bouderlique T, Sejnohova M, Zikmund T, Kozhemyakina E, Xie M, Krivanek J, Kaiser J, Qian H, Dyachuk V, Lassar AB, Warman ML, Barenius B, Adameyko I, Chagin AS. Superficial cells are self-renewing chondrocyte progenitors, which form the articular cartilage in juvenile mice. FASEB J. 2017 03; 31(3):1067-1084. PMID: 27965322.
    View in: PubMed
  3. Kozhemyakina E, Zhang M, Ionescu A, Ayturk UM, Ono N, Kobayashi A, Kronenberg H, Warman ML, Lassar AB. Identification of a Prg4-expressing articular cartilage progenitor cell population in mice. Arthritis Rheumatol. 2015 May; 67(5):1261-73. PMID: 25603997; PMCID: PMC4414823.
  4. Kozhemyakina E, Lassar AB, Zelzer E. A pathway to bone: signaling molecules and transcription factors involved in chondrocyte development and maturation. Development. 2015 Mar 01; 142(5):817-31. PMID: 25715393; PMCID: PMC4352987.
  5. Daoud G, Kempf H, Kumar D, Kozhemyakina E, Holowacz T, Kim DW, Ionescu A, Lassar AB. BMP-mediated induction of GATA4/5/6 blocks somitic responsiveness to SHH. Development. 2014 Oct; 141(20):3978-87. PMID: 25294942; PMCID: PMC4197703.
  6. Kumar D, Lassar AB. Fibroblast growth factor maintains chondrogenic potential of limb bud mesenchymal cells by modulating DNMT3A recruitment. Cell Rep. 2014 Sep 11; 8(5):1419-31. PMID: 25159139; PMCID: PMC4163101.
  7. Ogawa H, Kozhemyakina E, Hung HH, Grodzinsky AJ, Lassar AB. Mechanical motion promotes expression of Prg4 in articular cartilage via multiple CREB-dependent, fluid flow shear stress-induced signaling pathways. Genes Dev. 2014 Jan 15; 28(2):127-39. PMID: 24449269; PMCID: PMC3909787.
  8. Kozhemyakina E, Ionescu A, Lassar AB. GATA6 is a crucial regulator of Shh in the limb bud. PLoS Genet. 2014 Jan; 10(1):e1004072. PMID: 24415953; PMCID: PMC3886911.
  9. Clark CD, Zhang B, Lee B, Evans SI, Lassar AB, Lee KH. Evolutionary conservation of Nkx2.5 autoregulation in the second heart field. Dev Biol. 2013 Feb 01; 374(1):198-209. PMID: 23165293; PMCID: PMC3549048.
  10. Ionescu A, Kozhemyakina E, Nicolae C, Kaestner KH, Olsen BR, Lassar AB. FoxA family members are crucial regulators of the hypertrophic chondrocyte differentiation program. Dev Cell. 2012 May 15; 22(5):927-39. PMID: 22595668; PMCID: PMC3356573.
  11. Lassar A. Finding MyoD with a little help from my friends. Nat Cell Biol. 2012 Feb 02; 14(2):116. PMID: 22298038.
    View in: PubMed
  12. Kamei CN, Kempf H, Yelin R, Daoud G, James RG, Lassar AB, Tabin CJ, Schultheiss TM. Promotion of avian endothelial cell differentiation by GATA transcription factors. Dev Biol. 2011 May 01; 353(1):29-37. PMID: 21354132; PMCID: PMC3165022.
  13. Lassar AB. The p38 MAPK family, a pushmi-pullyu of skeletal muscle differentiation. J Cell Biol. 2009 Dec 28; 187(7):941-3. PMID: 20026653; PMCID: PMC2806286.
  14. Kozhemyakina E, Cohen T, Yao TP, Lassar AB. Parathyroid hormone-related peptide represses chondrocyte hypertrophy through a protein phosphatase 2A/histone deacetylase 4/MEF2 pathway. Mol Cell Biol. 2009 Nov; 29(21):5751-62. PMID: 19704004; PMCID: PMC2772746.
  15. Kumar D, Lassar AB. The transcriptional activity of Sox9 in chondrocytes is regulated by RhoA signaling and actin polymerization. Mol Cell Biol. 2009 Aug; 29(15):4262-73. PMID: 19470758; PMCID: PMC2715793.
  16. Kumar D, Shadrach JL, Wagers AJ, Lassar AB. Id3 is a direct transcriptional target of Pax7 in quiescent satellite cells. Mol Biol Cell. 2009 Jul; 20(14):3170-7. PMID: 19458195.
    View in: PubMed
  17. Cairns DM, Sato ME, Lee PG, Lassar AB, Zeng L. A gradient of Shh establishes mutually repressing somitic cell fates induced by Nkx3.2 and Pax3. Dev Biol. 2008 Nov 15; 323(2):152-65. PMID: 18796301; PMCID: PMC3766898.
  18. Kempf H, Ionescu A, Udager AM, Lassar AB. Prochondrogenic signals induce a competence for Runx2 to activate hypertrophic chondrocyte gene expression. Dev Dyn. 2007 Jul; 236(7):1954-62. PMID: 17576141.
    View in: PubMed
  19. Holowacz T, Zeng L, Lassar AB. Asymmetric localization of numb in the chick somite and the influence of myogenic signals. Dev Dyn. 2006 Mar; 235(3):633-45. PMID: 16425215; PMCID: PMC2561193.
  20. Provot S, Kempf H, Murtaugh LC, Chung UI, Kim DW, Chyung J, Kronenberg HM, Lassar AB. Nkx3.2/Bapx1 acts as a negative regulator of chondrocyte maturation. Development. 2006 Feb; 133(4):651-62. PMID: 16421188.
    View in: PubMed
  21. Lee KH, Evans S, Ruan TY, Lassar AB. SMAD-mediated modulation of YY1 activity regulates the BMP response and cardiac-specific expression of a GATA4/5/6-dependent chick Nkx2.5 enhancer. Development. 2004 Oct; 131(19):4709-23. PMID: 15329343.
    View in: PubMed
  22. Tzahor E, Kempf H, Mootoosamy RC, Poon AC, Abzhanov A, Tabin CJ, Dietrich S, Lassar AB. Antagonists of Wnt and BMP signaling promote the formation of vertebrate head muscle. Genes Dev. 2003 Dec 15; 17(24):3087-99. PMID: 14701876.
    View in: PubMed
  23. Kim DW, Lassar AB. Smad-dependent recruitment of a histone deacetylase/Sin3A complex modulates the bone morphogenetic protein-dependent transcriptional repressor activity of Nkx3.2. Mol Cell Biol. 2003 Dec; 23(23):8704-17. PMID: 14612411; PMCID: PMC262671.
  24. Abzhanov A, Tzahor E, Lassar AB, Tabin CJ. Dissimilar regulation of cell differentiation in mesencephalic (cranial) and sacral (trunk) neural crest cells in vitro. Development. 2003 Oct; 130(19):4567-79. PMID: 12925584.
    View in: PubMed
  25. Kim DW, Kempf H, Chen RE, Lassar AB. Characterization of Nkx3.2 DNA binding specificity and its requirement for somitic chondrogenesis. J Biol Chem. 2003 Jul 25; 278(30):27532-9. PMID: 12746429.
    View in: PubMed
  26. Stuckmann I, Evans S, Lassar AB. Erythropoietin and retinoic acid, secreted from the epicardium, are required for cardiac myocyte proliferation. Dev Biol. 2003 Mar 15; 255(2):334-49. PMID: 12648494.
    View in: PubMed
  27. Zeng L, Kempf H, Murtaugh LC, Sato ME, Lassar AB. Shh establishes an Nkx3.2/Sox9 autoregulatory loop that is maintained by BMP signals to induce somitic chondrogenesis. Genes Dev. 2002 Aug 01; 16(15):1990-2005. PMID: 12154128; PMCID: PMC186419.
  28. Lazaro JB, Bailey PJ, Lassar AB. Cyclin D-cdk4 activity modulates the subnuclear localization and interaction of MEF2 with SRC-family coactivators during skeletal muscle differentiation. Genes Dev. 2002 Jul 15; 16(14):1792-805. PMID: 12130539; PMCID: PMC186397.
  29. Stuckmann I, Lassar AB. Erythropoietin and retinoic acid signaling in the epicardium is required for cardiac myocyte proliferation. Cold Spring Harb Symp Quant Biol. 2002; 67:45-8. PMID: 12858522.
    View in: PubMed
  30. Bailey P, Holowacz T, Lassar AB. The origin of skeletal muscle stem cells in the embryo and the adult. Curr Opin Cell Biol. 2001 Dec; 13(6):679-89. PMID: 11698183.
    View in: PubMed
  31. Schweitzer R, Chyung JH, Murtaugh LC, Brent AE, Rosen V, Olson EN, Lassar A, Tabin CJ. Analysis of the tendon cell fate using Scleraxis, a specific marker for tendons and ligaments. Development. 2001 Oct; 128(19):3855-66. PMID: 11585810.
    View in: PubMed
  32. Murtaugh LC, Zeng L, Chyung JH, Lassar AB. The chick transcriptional repressor Nkx3.2 acts downstream of Shh to promote BMP-dependent axial chondrogenesis. Dev Cell. 2001 Sep; 1(3):411-22. PMID: 11702952.
    View in: PubMed
  33. Nielsen C, Murtaugh LC, Chyung JC, Lassar A, Roberts DJ. Gizzard formation and the role of Bapx1. Dev Biol. 2001 Mar 01; 231(1):164-74. PMID: 11180960.
    View in: PubMed
  34. Marvin MJ, Di Rocco G, Gardiner A, Bush SM, Lassar AB. Inhibition of Wnt activity induces heart formation from posterior mesoderm. Genes Dev. 2001 Feb 01; 15(3):316-27. PMID: 11159912; PMCID: PMC312622.
  35. Tzahor E, Lassar AB. Wnt signals from the neural tube block ectopic cardiogenesis. Genes Dev. 2001 Feb 01; 15(3):255-60. PMID: 11159906; PMCID: PMC312627.
  36. Heanue TA, Reshef R, Davis RJ, Mardon G, Oliver G, Tomarev S, Lassar AB, Tabin CJ. Synergistic regulation of vertebrate muscle development by Dach2, Eya2, and Six1, homologs of genes required for Drosophila eye formation. Genes Dev. 1999 Dec 15; 13(24):3231-43. PMID: 10617572; PMCID: PMC317207.
  37. Zhu L, Marvin MJ, Gardiner A, Lassar AB, Mercola M, Stern CD, Levin M. Cerberus regulates left-right asymmetry of the embryonic head and heart. Curr Biol. 1999 Sep 09; 9(17):931-8. PMID: 10508582.
    View in: PubMed
  38. Novitch BG, Spicer DB, Kim PS, Cheung WL, Lassar AB. pRb is required for MEF2-dependent gene expression as well as cell-cycle arrest during skeletal muscle differentiation. Curr Biol. 1999 May 06; 9(9):449-59. PMID: 10322110.
    View in: PubMed
  39. Murtaugh LC, Chyung JH, Lassar AB. Sonic hedgehog promotes somitic chondrogenesis by altering the cellular response to BMP signaling. Genes Dev. 1999 Jan 15; 13(2):225-37. PMID: 9925646; PMCID: PMC316396.
  40. Reshef R, Maroto M, Lassar AB. Regulation of dorsal somitic cell fates: BMPs and Noggin control the timing and pattern of myogenic regulator expression. Genes Dev. 1998 Feb 01; 12(3):290-303. PMID: 9450925; PMCID: PMC316485.
  41. Sellers WR, Novitch BG, Miyake S, Heith A, Otterson GA, Kaye FJ, Lassar AB, Kaelin WG. Stable binding to E2F is not required for the retinoblastoma protein to activate transcription, promote differentiation, and suppress tumor cell growth. Genes Dev. 1998 Jan 01; 12(1):95-106. PMID: 9420334; PMCID: PMC316399.
  42. Maroto M, Reshef R, Münsterberg AE, Koester S, Goulding M, Lassar AB. Ectopic Pax-3 activates MyoD and Myf-5 expression in embryonic mesoderm and neural tissue. Cell. 1997 Apr 04; 89(1):139-48. PMID: 9094722.
    View in: PubMed
  43. Schultheiss TM, Burch JB, Lassar AB. A role for bone morphogenetic proteins in the induction of cardiac myogenesis. Genes Dev. 1997 Feb 15; 11(4):451-62. PMID: 9042859.
    View in: PubMed
  44. Schultheiss TM, Lassar AB. Induction of chick cardiac myogenesis by bone morphogenetic proteins. Cold Spring Harb Symp Quant Biol. 1997; 62:413-9. PMID: 9598376.
    View in: PubMed
  45. Skapek SX, Rhee J, Kim PS, Novitch BG, Lassar AB. Cyclin-mediated inhibition of muscle gene expression via a mechanism that is independent of pRB hyperphosphorylation. Mol Cell Biol. 1996 Dec; 16(12):7043-53. PMID: 8943359; PMCID: PMC231707.
  46. Novitch BG, Mulligan GJ, Jacks T, Lassar AB. Skeletal muscle cells lacking the retinoblastoma protein display defects in muscle gene expression and accumulate in S and G2 phases of the cell cycle. J Cell Biol. 1996 Oct; 135(2):441-56. PMID: 8896600; PMCID: PMC2121049.
  47. Spicer DB, Rhee J, Cheung WL, Lassar AB. Inhibition of myogenic bHLH and MEF2 transcription factors by the bHLH protein Twist. Science. 1996 Jun 07; 272(5267):1476-80. PMID: 8633239.
    View in: PubMed
  48. Lassar AB, Münsterberg AE. The role of positive and negative signals in somite patterning. Curr Opin Neurobiol. 1996 Feb; 6(1):57-63. PMID: 8794041.
    View in: PubMed
  49. Schultheiss TM, Xydas S, Lassar AB. Induction of avian cardiac myogenesis by anterior endoderm. Development. 1995 Dec; 121(12):4203-14. PMID: 8575320.
    View in: PubMed
  50. Münsterberg AE, Kitajewski J, Bumcrot DA, McMahon AP, Lassar AB. Combinatorial signaling by Sonic hedgehog and Wnt family members induces myogenic bHLH gene expression in the somite. Genes Dev. 1995 Dec 01; 9(23):2911-22. PMID: 7498788.
    View in: PubMed
  51. Münsterberg AE, Lassar AB. Combinatorial signals from the neural tube, floor plate and notochord induce myogenic bHLH gene expression in the somite. Development. 1995 Mar; 121(3):651-60. PMID: 7720573.
    View in: PubMed
  52. Skapek SX, Rhee J, Spicer DB, Lassar AB. Inhibition of myogenic differentiation in proliferating myoblasts by cyclin D1-dependent kinase. Science. 1995 Feb 17; 267(5200):1022-4. PMID: 7863328.
    View in: PubMed
  53. Halevy O, Novitch BG, Spicer DB, Skapek SX, Rhee J, Hannon GJ, Beach D, Lassar AB. Correlation of terminal cell cycle arrest of skeletal muscle with induction of p21 by MyoD. Science. 1995 Feb 17; 267(5200):1018-21. PMID: 7863327.
    View in: PubMed
  54. Lassar AB, Skapek SX, Novitch B. Regulatory mechanisms that coordinate skeletal muscle differentiation and cell cycle withdrawal. Curr Opin Cell Biol. 1994 Dec; 6(6):788-94. PMID: 7880524.
    View in: PubMed
  55. Lassar A, Münsterberg A. Wiring diagrams: regulatory circuits and the control of skeletal myogenesis. Curr Opin Cell Biol. 1994 Jun; 6(3):432-42. PMID: 7917336.
    View in: PubMed
  56. Tapscott SJ, Lassar AB, Weintraub H. A novel myoblast enhancer element mediates MyoD transcription. Mol Cell Biol. 1992 Nov; 12(11):4994-5003. PMID: 1328870; PMCID: PMC360432.
  57. Weintraub H, Dwarki VJ, Verma I, Davis R, Hollenberg S, Snider L, Lassar A, Tapscott SJ. Muscle-specific transcriptional activation by MyoD. Genes Dev. 1991 Aug; 5(8):1377-86. PMID: 1651276.
    View in: PubMed
  58. Lassar AB, Davis RL, Wright WE, Kadesch T, Murre C, Voronova A, Baltimore D, Weintraub H. Functional activity of myogenic HLH proteins requires hetero-oligomerization with E12/E47-like proteins in vivo. Cell. 1991 Jul 26; 66(2):305-15. PMID: 1649701.
    View in: PubMed
  59. Crescenzi M, Fleming TP, Lassar AB, Weintraub H, Aaronson SA. MyoD induces growth arrest independent of differentiation in normal and transformed cells. Proc Natl Acad Sci U S A. 1990 Nov; 87(21):8442-6. PMID: 2236052; PMCID: PMC54972.
  60. Weintraub H, Davis R, Lockshon D, Lassar A. MyoD binds cooperatively to two sites in a target enhancer sequence: occupancy of two sites is required for activation. Proc Natl Acad Sci U S A. 1990 Aug; 87(15):5623-7. PMID: 2377600; PMCID: PMC54379.
  61. Davis RL, Cheng PF, Lassar AB, Weintraub H. The MyoD DNA binding domain contains a recognition code for muscle-specific gene activation. Cell. 1990 Mar 09; 60(5):733-46. PMID: 2155707.
    View in: PubMed
  62. Tapscott SJ, Davis RL, Lassar AB, Weintraub H. MyoD: a regulatory gene of skeletal myogenesis. Adv Exp Med Biol. 1990; 280:3-5; discussion 5-6. PMID: 2248151.
    View in: PubMed
  63. Benezra R, Davis RL, Lassar A, Tapscott S, Thayer M, Lockshon D, Weintraub H. Id: a negative regulator of helix-loop-helix DNA binding proteins. Control of terminal myogenic differentiation. Ann N Y Acad Sci. 1990; 599:1-11. PMID: 2171390.
    View in: PubMed
  64. Sassoon D, Lyons G, Wright WE, Lin V, Lassar A, Weintraub H, Buckingham M. Expression of two myogenic regulatory factors myogenin and MyoD1 during mouse embryogenesis. Nature. 1989 Sep 28; 341(6240):303-7. PMID: 2552320.
    View in: PubMed
  65. Lassar AB, Buskin JN, Lockshon D, Davis RL, Apone S, Hauschka SD, Weintraub H. MyoD is a sequence-specific DNA binding protein requiring a region of myc homology to bind to the muscle creatine kinase enhancer. Cell. 1989 Sep 08; 58(5):823-31. PMID: 2550138.
    View in: PubMed
  66. Lassar AB, Thayer MJ, Overell RW, Weintraub H. Transformation by activated ras or fos prevents myogenesis by inhibiting expression of MyoD1. Cell. 1989 Aug 25; 58(4):659-67. PMID: 2548731.
    View in: PubMed
  67. Murre C, McCaw PS, Vaessin H, Caudy M, Jan LY, Jan YN, Cabrera CV, Buskin JN, Hauschka SD, Lassar AB, et al. Interactions between heterologous helix-loop-helix proteins generate complexes that bind specifically to a common DNA sequence. Cell. 1989 Aug 11; 58(3):537-44. PMID: 2503252.
    View in: PubMed
  68. Tapscott SJ, Lassar AB, Davis RL, Weintraub H. 5-bromo-2'-deoxyuridine blocks myogenesis by extinguishing expression of MyoD1. Science. 1989 Aug 04; 245(4917):532-6. PMID: 2547249.
    View in: PubMed
  69. Thayer MJ, Tapscott SJ, Davis RL, Wright WE, Lassar AB, Weintraub H. Positive autoregulation of the myogenic determination gene MyoD1. Cell. 1989 Jul 28; 58(2):241-8. PMID: 2546677.
    View in: PubMed
  70. Weintraub H, Tapscott SJ, Davis RL, Thayer MJ, Adam MA, Lassar AB, Miller AD. Activation of muscle-specific genes in pigment, nerve, fat, liver, and fibroblast cell lines by forced expression of MyoD. Proc Natl Acad Sci U S A. 1989 Jul; 86(14):5434-8. PMID: 2748593; PMCID: PMC297637.
  71. Davis RL, Cheng PF, Lassar AB, Thayer M, Tapscott S, Weintraub H. MyoD and achaete-scute: 4-5 amino acids distinguishes myogenesis from neurogenesis. Princess Takamatsu Symp. 1989; 20:267-78. PMID: 2562185.
    View in: PubMed
  72. Tapscott SJ, Davis RL, Thayer MJ, Cheng PF, Weintraub H, Lassar AB. MyoD1: a nuclear phosphoprotein requiring a Myc homology region to convert fibroblasts to myoblasts. Science. 1988 Oct 21; 242(4877):405-11. PMID: 3175662.
    View in: PubMed
  73. Davis RL, Weintraub H, Lassar AB. Expression of a single transfected cDNA converts fibroblasts to myoblasts. Cell. 1987 Dec 24; 51(6):987-1000. PMID: 3690668.
    View in: PubMed
  74. Lassar AB, Paterson BM, Weintraub H. Transfection of a DNA locus that mediates the conversion of 10T1/2 fibroblasts to myoblasts. Cell. 1986 Dec 05; 47(5):649-56. PMID: 2430720.
    View in: PubMed
  75. Lassar AB, Hamer DH, Roeder RG. Stable transcription complex on a class III gene in a minichromosome. Mol Cell Biol. 1985 Jan; 5(1):40-5. PMID: 2984553; PMCID: PMC366675.
  76. Lassar AB, Martin PL, Roeder RG. Transcription of class III genes: formation of preinitiation complexes. Science. 1983 Nov 18; 222(4625):740-8. PMID: 6356356.
    View in: PubMed
  77. Apirion D, Lassar AB. A conditional lethal mutant of Escherichia coli which affects the processing of ribosomal RNA. J Biol Chem. 1978 Mar 10; 253(5):1738-42. PMID: 342528.
    View in: PubMed
Local representatives can answer questions about the Profiles website or help with editing a profile or issues with profile data. For assistance with this profile: HMS/HSDM faculty should contact feedbackcatalyst.harvard.edu. For faculty or fellow appointment updates and changes, please ask your appointing department to contact HMS. For fellow personal and demographic information, contact HMS Human Resources at human_resourceshms.harvard.edu. For faculty personal and demographic information, contact HMS Office for Faculty Affairs at facappthms.harvard.edu.
Lassar's Networks
Click the
Explore
buttons for more information and interactive visualizations!
Concepts (350)
Explore
_
Co-Authors (11)
Explore
_
Similar People (60)
Explore
_
Same Department 
Explore
_
Physical Neighbors
_
Tool Page Footer - Harvard Catalyst Tool Page Footer – Harvard Catalyst
Funded by the NIH/NCATS Clinical and Translational Science Award (CTSA) program, grant number UL1TR001102, and through institutional support from Harvard University, Harvard Medical School, Harvard T.H. Chan School of Public Health, Beth Israel Deaconess Medical Center, Boston Children's Hospital, Brigham and Women's Hospital, Massachusetts General Hospital and the Dana Farber Cancer Institute.