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Pradeep Sundaram Rajendran, M.D.

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UCLAPh.D.06/2017Molecular, Cellular, & Integrative Physiology
Stanford UniversityB.S.06/2009Biomechanical Engineering

The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. F31HL127974 (RAJENDRAN, PRADEEP SUNDARAM) May 1, 2015 - Apr 30, 2018
    Myocardial infarction alters information processing within the intrinsic cardiac nervous system
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Hoang JD, Yamakawa K, Rajendran PS, Chan CA, Yagishita D, Nakamura K, Lux RL, Vaseghi M. Proarrhythmic Effects of Sympathetic Activation Are Mitigated by Vagal Nerve Stimulation in Infarcted Hearts. JACC Clin Electrophysiol. 2022 04; 8(4):513-525. PMID: 35450607; PMCID: PMC9034056.
    Citations:    Fields:    Translation:HumansAnimals
  2. Zhu C, Rajendran PS, Hanna P, Efimov IR, Salama G, Fowlkes CC, Shivkumar K. High-resolution structure-function mapping of intact hearts reveals altered sympathetic control of infarct border zones. JCI Insight. 2022 02 08; 7(3). PMID: 35132963; PMCID: PMC8855798.
    Citations:    Fields:    Translation:Animals
  3. Rajendran PS, Stavrakis S. The Intricate Role of Spinal Cord Glial Cells in Sympathoexcitation and Arrhythmogenesis: The Plot Thickens. JACC Clin Electrophysiol. 2021 10; 7(10):1226-1228. PMID: 34674836.
    Citations:    Fields:    Translation:HumansCells
  4. Kronschläger MT, Siegert ASM, Resch FJ, Rajendran PS, Khakh BS, Sandkühler J. Lamina-specific properties of spinal astrocytes. Glia. 2021 07; 69(7):1749-1766. PMID: 33694249; PMCID: PMC8252791.
    Citations: 3     Fields:    Translation:AnimalsCells
  5. Hanna P, Dacey MJ, Brennan J, Moss A, Robbins S, Achanta S, Biscola NP, Swid MA, Rajendran PS, Mori S, Hadaya JE, Smith EH, Peirce SG, Chen J, Havton LA, Cheng ZJ, Vadigepalli R, Schwaber J, Lux RL, Efimov I, Tompkins JD, Hoover DB, Ardell JL, Shivkumar K. Innervation and Neuronal Control of the Mammalian Sinoatrial Node a Comprehensive Atlas. Circ Res. 2021 04 30; 128(9):1279-1296. PMID: 33629877; PMCID: PMC8284939.
    Citations: 17     Fields:    Translation:HumansAnimalsCells
  6. Fontaine AK, Futia GL, Rajendran PS, Littich SF, Mizoguchi N, Shivkumar K, Ardell JL, Restrepo D, Caldwell JH, Gibson EA, Weir RFF. Optical vagus nerve modulation of heart and respiration via heart-injected retrograde AAV. Sci Rep. 2021 02 11; 11(1):3664. PMID: 33574459.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  7. Yoshie K, Rajendran PS, Massoud L, Mistry J, Swid MA, Wu X, Sallam T, Zhang R, Goldhaber JI, Salavatian S, Ajijola OA. Cardiac TRPV1 afferent signaling promotes arrhythmogenic ventricular remodeling after myocardial infarction. JCI Insight. 2020 02 13; 5(3). PMID: 31846438.
    Citations: 15     Fields:    Translation:HumansAnimalsCells
  8. Jungen C, Scherschel K, Flenner F, Jee H, Rajendran P, De Jong KA, Nikolaev V, Meyer C, Ardell JL, Tompkins JD. Increased arrhythmia susceptibility in type 2 diabetic mice related to dysregulation of ventricular sympathetic innervation. Am J Physiol Heart Circ Physiol. 2019 12 01; 317(6):H1328-H1341. PMID: 31625779; PMCID: PMC6962614.
    Citations: 5     Fields:    Translation:AnimalsCells
  9. Zhu C, Hanna P, Rajendran PS, Shivkumar K. Neuromodulation for Ventricular Tachycardia and Atrial Fibrillation: A Clinical Scenario-Based Review. JACC Clin Electrophysiol. 2019 08; 5(8):881-896. PMID: 31439288.
    Citations: 13     Fields:    Translation:Humans
  10. Challis RC, Kumar SR, Chan KY, Challis C, Beadle K, Jang MJ, Kim HM, Rajendran PS, Tompkins JD, Shivkumar K, Deverman BE, Gradinaru V. Publisher Correction: Systemic AAV vectors for widespread and targeted gene delivery in rodents. Nat Protoc. 2019 Aug; 14(8):2597. PMID: 31312046.
    Citations: 3     Fields:    
  11. Hanna P, Zhu C, Rajendran PS, Shivkumar K. Anesthetizing the Fibrillating Heart. J Am Heart Assoc. 2019 05 21; 8(10):e012713. PMID: 31068060.
    Citations: 1     Fields:    Translation:HumansAnimals
  12. Rajendran PS, Challis RC, Fowlkes CC, Hanna P, Tompkins JD, Jordan MC, Hiyari S, Gabris-Weber BA, Greenbaum A, Chan KY, Deverman BE, Münzberg H, Ardell JL, Salama G, Gradinaru V, Shivkumar K. Identification of peripheral neural circuits that regulate heart rate using optogenetic and viral vector strategies. Nat Commun. 2019 04 26; 10(1):1944. PMID: 31028266.
    Citations: 43     Fields:    Translation:AnimalsCells
  13. Hamon D, Swid MA, Rajendran PS, Liu A, Boyle NG, Shivkumar K, Bradfield JS. Premature ventricular contraction diurnal profiles predict distinct clinical characteristics and beta-blocker responses. J Cardiovasc Electrophysiol. 2019 06; 30(6):836-843. PMID: 30964570.
    Citations: 4     Fields:    Translation:Humans
  14. Rajendran PS, Hanna P, Zhu C, Shivkumar K. Neuroinflammation as a mechanism for cardiovascular diseases. Int J Cardiol. 2019 08 01; 288:128-129. PMID: 30979606; PMCID: PMC7155386.
    Citations: 1     Fields:    Translation:Humans
  15. Challis RC, Ravindra Kumar S, Chan KY, Challis C, Beadle K, Jang MJ, Kim HM, Rajendran PS, Tompkins JD, Shivkumar K, Deverman BE, Gradinaru V. Systemic AAV vectors for widespread and targeted gene delivery in rodents. Nat Protoc. 2019 02; 14(2):379-414. PMID: 30626963.
    Citations: 73     Fields:    Translation:HumansAnimalsCells
  16. Hanna P, Rajendran PS, Shivkumar K. Neural ablation to treat ventricular arrhythmias. Europace. 2018 12 01; 20(12):1880-1881. PMID: 29931207; PMCID: PMC6275468.
    Citations:    Fields:    Translation:AnimalsCells
  17. Yamaguchi N, Yamakawa K, Rajendran PS, Takamiya T, Vaseghi M. Antiarrhythmic effects of vagal nerve stimulation after cardiac sympathetic denervation in the setting of chronic myocardial infarction. Heart Rhythm. 2018 08; 15(8):1214-1222. PMID: 29530832.
    Citations: 9     Fields:    Translation:Animals
  18. Yoshie K, Rajendran PS, Massoud L, Kwon O, Tadimeti V, Salavatian S, Ardell JL, Shivkumar K, Ajijola OA. Cardiac vanilloid receptor-1 afferent depletion enhances stellate ganglion neuronal activity and efferent sympathetic response to cardiac stress. Am J Physiol Heart Circ Physiol. 2018 05 01; 314(5):H954-H966. PMID: 29351450; PMCID: PMC6008140.
    Citations: 5     Fields:    Translation:AnimalsCells
  19. Vaseghi M, Salavatian S, Rajendran PS, Yagishita D, Woodward WR, Hamon D, Yamakawa K, Irie T, Habecker BA, Shivkumar K. Parasympathetic dysfunction and antiarrhythmic effect of vagal nerve stimulation following myocardial infarction. JCI Insight. 2017 Aug 17; 2(16). PMID: 28814663.
    Citations: 27     Fields:    
  20. Hanna P, Rajendran PS, Ajijola OA, Vaseghi M, Andrew Armour J, Ardell JL, Shivkumar K. Cardiac neuroanatomy - Imaging nerves to define functional control. Auton Neurosci. 2017 Nov; 207:48-58. PMID: 28802636.
    Citations: 14     Fields:    Translation:HumansCells
  21. Chai H, Diaz-Castro B, Shigetomi E, Monte E, Octeau JC, Yu X, Cohn W, Rajendran PS, Vondriska TM, Whitelegge JP, Coppola G, Khakh BS. Neural Circuit-Specialized Astrocytes: Transcriptomic, Proteomic, Morphological, and Functional Evidence. Neuron. 2017 Aug 02; 95(3):531-549.e9. PMID: 28712653.
    Citations: 236     Fields:    Translation:AnimalsCells
  22. Chui RW, Buckley U, Rajendran PS, Vrabec T, Shivkumar K, Ardell JL. Bioelectronic block of paravertebral sympathetic nerves mitigates post-myocardial infarction ventricular arrhythmias. Heart Rhythm. 2017 11; 14(11):1665-1672. PMID: 28629852.
    Citations: 11     Fields:    Translation:Animals
  23. Hamon D, Rajendran PS, Chui RW, Ajijola OA, Irie T, Talebi R, Salavatian S, Vaseghi M, Bradfield JS, Armour JA, Ardell JL, Shivkumar K. Premature Ventricular Contraction Coupling Interval Variability Destabilizes Cardiac Neuronal and Electrophysiological Control: Insights From Simultaneous Cardioneural Mapping. Circ Arrhythm Electrophysiol. 2017 Apr; 10(4). PMID: 28408652.
    Citations: 14     Fields:    Translation:Animals
  24. Buckley U, Chui RW, Rajendran PS, Vrabec T, Shivkumar K, Ardell JL. Bioelectronic neuromodulation of the paravertebral cardiac efferent sympathetic outflow and its effect on ventricular electrical indices. Heart Rhythm. 2017 07; 14(7):1063-1070. PMID: 28219848.
    Citations: 7     Fields:    Translation:Animals
  25. Buckley U, Rajendran PS, Shivkumar K. Ganglionated plexus ablation for atrial fibrillation: Just because we can, does that mean we should? Heart Rhythm. 2017 01; 14(1):133-134. PMID: 28007095.
    Citations: 4     Fields:    Translation:Humans
  26. Dalerba P, Sahoo D, Paik S, Guo X, Yothers G, Song N, Wilcox-Fogel N, Forgó E, Rajendran PS, Miranda SP, Hisamori S, Hutchison J, Kalisky T, Qian D, Wolmark N, Fisher GA, van de Rijn M, Clarke MF. CDX2 as a Prognostic Biomarker in Stage II and Stage III Colon Cancer. N Engl J Med. 2016 Jan 21; 374(3):211-22. PMID: 26789870; PMCID: PMC4784450.
    Citations: 170     Fields:    Translation:Humans
  27. Rajendran PS, Nakamura K, Ajijola OA, Vaseghi M, Armour JA, Ardell JL, Shivkumar K. Myocardial infarction induces structural and functional remodelling of the intrinsic cardiac nervous system. J Physiol. 2016 Jan 15; 594(2):321-41. PMID: 26572244; PMCID: PMC4713729.
    Citations: 59     Fields:    Translation:AnimalsCells
  28. Yamakawa K, Howard-Quijano K, Zhou W, Rajendran P, Yagishita D, Vaseghi M, Ajijola OA, Armour JA, Shivkumar K, Ardell JL, Mahajan A. Central vs. peripheral neuraxial sympathetic control of porcine ventricular electrophysiology. Am J Physiol Regul Integr Comp Physiol. 2016 Mar 01; 310(5):R414-21. PMID: 26661096; PMCID: PMC4796738.
    Citations: 8     Fields:    Translation:AnimalsCells
  29. Yamakawa K, Rajendran PS, Takamiya T, Yagishita D, So EL, Mahajan A, Shivkumar K, Vaseghi M. Vagal nerve stimulation activates vagal afferent fibers that reduce cardiac efferent parasympathetic effects. Am J Physiol Heart Circ Physiol. 2015 Nov; 309(9):H1579-90. PMID: 26371172; PMCID: PMC4666973.
    Citations: 32     Fields:    Translation:Animals
  30. Ardell JL, Rajendran PS, Nier HA, KenKnight BH, Armour JA. Central-peripheral neural network interactions evoked by vagus nerve stimulation: functional consequences on control of cardiac function. Am J Physiol Heart Circ Physiol. 2015 Nov 15; 309(10):H1740-52. PMID: 26371171; PMCID: PMC4666982.
    Citations: 61     Fields:    Translation:Animals
  31. Yagishita D, Chui RW, Yamakawa K, Rajendran PS, Ajijola OA, Nakamura K, So EL, Mahajan A, Shivkumar K, Vaseghi M. Sympathetic nerve stimulation, not circulating norepinephrine, modulates T-peak to T-end interval by increasing global dispersion of repolarization. Circ Arrhythm Electrophysiol. 2015 Feb; 8(1):174-85. PMID: 25532528.
    Citations: 49     Fields:    Translation:Animals
  32. Yamakawa K, So EL, Rajendran PS, Hoang JD, Makkar N, Mahajan A, Shivkumar K, Vaseghi M. Electrophysiological effects of right and left vagal nerve stimulation on the ventricular myocardium. Am J Physiol Heart Circ Physiol. 2014 Sep 01; 307(5):H722-31. PMID: 25015962.
    Citations: 28     Fields:    Translation:Animals
  33. Rajendran PS, Buch E, Shivkumar K. Marshaling the autonomic nervous system for treatment of atrial fibrillation. J Am Coll Cardiol. 2014 May 13; 63(18):1902-3. PMID: 24561143; PMCID: PMC4219829.
    Citations: 3     Fields:    Translation:Humans
  34. Willingham SB, Volkmer JP, Gentles AJ, Sahoo D, Dalerba P, Mitra SS, Wang J, Contreras-Trujillo H, Martin R, Cohen JD, Lovelace P, Scheeren FA, Chao MP, Weiskopf K, Tang C, Volkmer AK, Naik TJ, Storm TA, Mosley AR, Edris B, Schmid SM, Sun CK, Chua MS, Murillo O, Rajendran P, Cha AC, Chin RK, Kim D, Adorno M, Raveh T, Tseng D, Jaiswal S, Enger PØ, Steinberg GK, Li G, So SK, Majeti R, Harsh GR, van de Rijn M, Teng NN, Sunwoo JB, Alizadeh AA, Clarke MF, Weissman IL. The CD47-signal regulatory protein alpha (SIRPa) interaction is a therapeutic target for human solid tumors. Proc Natl Acad Sci U S A. 2012 Apr 24; 109(17):6662-7. PMID: 22451913.
    Citations: 594     Fields:    Translation:Humans
  35. Dalerba P, Kalisky T, Sahoo D, Rajendran PS, Rothenberg ME, Leyrat AA, Sim S, Okamoto J, Johnston DM, Qian D, Zabala M, Bueno J, Neff NF, Wang J, Shelton AA, Visser B, Hisamori S, Shimono Y, van de Wetering M, Clevers H, Clarke MF, Quake SR. Single-cell dissection of transcriptional heterogeneity in human colon tumors. Nat Biotechnol. 2011 Nov 13; 29(12):1120-7. PMID: 22081019; PMCID: PMC3237928.
    Citations: 334     Fields:    Translation:HumansAnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.